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DNAJB5 Gene

protein-coding   GIFtS: 50
GCID: GC09P034991

DnaJ (Hsp40) Homolog, Subfamily B, Member 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 51 2     HSC403 5
Heat Shock Protein Cognate 402 3     DnaJ Homolog Subfamily B Member 52
Heat Shock Protein Hsp40-22 3     Heat Shock Cognate 402
Heat Shock Protein Hsp40-32 3     KIAA10455
Hsc402 3     

External Ids:    HGNC: 148871   Entrez Gene: 258222   Ensembl: ENSG000001370947   OMIM: 6113285   UniProtKB: O759533   

Export aliases for DNAJB5 gene to outside databases

Previous GC identifers: GC09P035301 GC09P035159 GC09P034979 GC09P034990 GC09P034944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJB5 Gene:
DNAJB5 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ
family, see MIM 608375.(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAJB5 Gene:
DNAJB5 (DnaJ (Hsp40) homolog, subfamily B, member 5) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJB4.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJB5 gene promoter:
         HEN1   RelA   ZIC2/Zic2   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB5 promoter sequence
   Search Chromatin IP Primers for DNAJB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p

DNAJB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034991:  view genomic region     (about GC identifiers)

Start:
34,989,638 bp from pter      End:
34,998,897 bp from pter
Size:
9,260 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNJB5_HUMAN, O75953 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 5  
Size: 348 amino acids; 39133 Da
Sequence caution: Sequence=AAH12115.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites;
Secondary accessions: B3KN14 B4DSA6 J3KQM9 J3KR08 Q5T656 Q8TDR7 Q96EM4
Alternative splicing: 3 isoforms:  O75953-3   O75953-4   O75953-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for DNAJB5: NX_O75953

Explore proteomics data for DNAJB5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128476.2  NP_001128477.1  NP_036398.3  

    ENSEMBL proteins: 
     ENSP00000404079   ENSP00000444290   ENSP00000393749   ENSP00000439217   ENSP00000433640  
     ENSP00000443151   ENSP00000413684   ENSP00000441999   ENSP00000445536   ENSP00000396332  
     ENSP00000337626   ENSP00000312517  

    DNAJB5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DNAJB5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DNAJB5
    GenScript Custom Purified and Recombinant Proteins Services for DNAJB5
    Novus Biologicals DNAJB5 Protein
    Novus Biologicals DNAJB5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJB5

     
    Search eBioscience for Proteins for DNAJB5 

     
    antibodies-online proteins for DNAJB5 (5 products) 

     
    antibodies-online peptides for DNAJB5

    DNAJB5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals DNAJB5 Antibodies
    Abcam antibodies for DNAJB5
    Cloud-Clone Corp. Antibodies for DNAJB5
    ThermoFisher Antibodies for DNAJB5
    antibodies-online antibodies for DNAJB5 (27 products) 

    DNAJB5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DNAJB5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNAJB5
    Cloud-Clone Corp. CLIAs for DNAJB5
    Search eBioscience for ELISAs for DNAJB5 
    antibodies-online kits for DNAJB5 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry O75953

    ProtoNet protein and cluster: O75953

    UniProtKB/Swiss-Prot: DNJB5_HUMAN, O75953
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJB5_HUMAN, O75953
    Induction: Expressed under normal conditions, its expression can further be increased after various stress
    treatments

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with DNAJB5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DNAJB5

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJB5:
    hsa-mir-192-5p (MIRT026797), hsa-mir-320a (MIRT044713), hsa-mir-215-5p (MIRT024402)

    Block miRNA regulation of human, mouse, rat DNAJB5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB5 (see all 42):
    hsa-miR-562 hsa-miR-429 hsa-miR-3138 hsa-miR-766 hsa-miR-649 hsa-miR-3613-3p hsa-miR-1243 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJB5
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAJB5

    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJB5 (see all 16)
    OriGene ORF clones in mouse, rat for DNAJB5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DNAJB5 (NM_001135004)
    Sino Biological Human cDNA Clone for DNAJB5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB5
    Addgene plasmids for DNAJB5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DNAJB5
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJB5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with DNAJB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB5: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJB5 (O759531, 2, 3 ENSP000004136844) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1AO005551, 3EBI-5655937,EBI-766279 I2D: score=1 
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    TBPL2Q6SJ963, ENSP000002472194I2D: score=1 STRING: ENSP00000247219
    WIPI2Q9Y4P83I2D: score=1 
    TTNQ8WZ421EBI-5655937,EBI-681210
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006457protein folding IEA--
    GO:0006986response to unfolded protein IEP10570961

    Find genes that share ontologies with DNAJB5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJB5 (DNJB5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJB5 gene (3 alternative transcripts): 
    NM_001135004.2  NM_001135005.2  NM_012266.5  

    Unigene Cluster for DNAJB5:

    DnaJ (Hsp40) homolog, subfamily B, member 5
    Hs.237506  [show with all ESTs]
    Unigene Representative Sequence: NM_001135005
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453597(uc003zvs.3 uc003zvt.3) ENST00000538278 ENST00000458263
    ENST00000537321 ENST00000469798 ENST00000541010 ENST00000454002(uc011los.2)
    ENST00000545841 ENST00000539059 ENST00000443266 ENST00000335998 ENST00000312316

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJB5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB5 (see all 42):
    hsa-miR-562 hsa-miR-429 hsa-miR-3138 hsa-miR-766 hsa-miR-649 hsa-miR-3613-3p hsa-miR-1243 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJB5
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB5
    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJB5 (see all 16)
    OriGene ORF clones in mouse, rat for DNAJB5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DNAJB5 (NM_001135004)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB5
    Addgene plasmids for DNAJB5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAJB5
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB5
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJB5
      QuantiFast Probe-based Assays in human, mouse, rat DNAJB5

    Additional mRNA sequence: 

    AF087870.1 AF088982.1 AK023253.1 AK299647.1 AK314671.1 

    10 DOTS entries:

    DT.100780870  DT.97843206  DT.99959264  DT.121195482  DT.121195434  DT.121195477  DT.95214211  DT.95272464 
    DT.95272468  DT.95301276 

    Selected AceView cDNA sequences (see all 174):

    BF793558 BU154414 BM559343 AF088982 AK023253 BM916097 BM708810 F03633 
    AA872652 AI972970 BI915181 AI952509 AI744087 AI971233 AA434108 BU156779 
    AU132351 AI023186 AI858541 AW498583 BU190497 BM561297 BM923931 F10358 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB5 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                    -     -     -           -     -                                                         
    SP2:                    -     -     -           -     -                                                         
    SP3:                    -     -           -     -     -                                                         
    SP4:                    -     -     -     -     -     -                                                         
    SP5:                    -                 -     -     -                                                         


    ECgene alternative splicing isoforms for DNAJB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAAGAAGC
    DNAJB5 Expression
    About this image


    DNAJB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    DNAJB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.237506
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB5: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJB5
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB5
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJB5
    QuantiFast Probe-based Assays in human, mouse, rat DNAJB5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb51 , 5 DnaJ (Hsp40) homolog, subfamily B, member 51, 5 93.49(n)1
    99.14(a)1
      4 (22.93 cM)5
    563231  NM_019874.31  NP_063927.11 
     429498145 
    chicken
    (Gallus gallus)
    Aves DNAJB51 DnaJ (Hsp40) homolog, subfamily B, member 5 78.3(n)
    85.56(a)
      427409  XM_004937116.1  XP_004937173.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB56
    DnaJ (Hsp40) homolog, subfamily B, member 5
    77(a)
    1 ↔ 1
    GL343305.1(1594561-1611243)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.181932 Transcribed sequence with moderate similarity to protein more 79.22(n)    AL956919.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajb51 DnaJ (Hsp40) homolog, subfamily B, member 5 71.46(n)
    76.72(a)
      569466  NM_001100040.1  NP_001093510.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DnaJ-13
    CG50011
    chaperone3
    CG50011
    50(a)
    (best of 3)3
    57.07(n)1
    53.78(a)1
      64E53
    333081  NM_001258904.21  NP_001245833.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-136
    Protein DNJ-13 (dnj-13) mRNA, complete cds
    56(a)
    1 → many
    II(11545701-11547366) WBGene00001031
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G205601 AT2G20560 53.17(n)
    44.24(a)
      816578  NM_127616.4  NP_179646.1 
    rice
    (Oryza sativa)
    Liliopsida Os.354632 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.2(n)    AK067414.1 


    ENSEMBL Gene Tree for DNAJB5 (if available)
    TreeFam Gene Tree for DNAJB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJB5 gene
    DNAJB42  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    Selected SIMAP similar genes for DNAJB5 using alignment to 8 protein entries:     DNJB5_HUMAN (see all proteins) (see all similar genes):
    DNAJA3    DNAJC16    DNAJC5B    DNAJB4    DNAJC1    DNAJB2
    DNAJC18    DNAJC5G    LOC51277    DNAJB1    DNAJB6    DNAJB3
    DNAJC10    DNAJB13    DNAJA4    DNAJC17    MST104    DNAJB12

    Find genes that share paralogs with DNAJB5           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for DNAJB5
    PGOHUM00000263088 PGOHUM00000235987 PGOHUM00000236217


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJB5 (see all 205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390003411,2
    --34942573(+) GAACCA/GAGGAC 2 -- us2k10--------
    rs1422485851,2
    --34987704(+) AGATCG/TGAGGA 2 -- us2k10--------
    rs1884255781,2
    --34987719(+) GCAGCA/GGTGCA 2 -- us2k10--------
    rs1932076011,2
    --34987731(+) GGCCCC/TTCACC 2 -- us2k10--------
    rs1855461891,2
    --34987827(+) TGTGCC/TTCATC 2 -- us2k10--------
    rs1141972611,2
    C,F--34987872(+) ACCCTG/ACCTTC 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs70486131,2
    C,F--34987944(+) gaggaA/C/G/
            
    aggag
    2 -- us2k1 trp32WA EA 238
    rs70354591,2
    C,F--34988026(+) tcaccG/Atcctc 2 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs106472251,2
    C--34988088(+) TCATGCTC/-CTCAT 2 -- cds11Minor allele frequency- -:0.50CSA 2
    rs359911381,2
    C--34988089(+) CATGC-/CTCTCATT 2 -- cds10--------

    HapMap Linkage Disequilibrium report for DNAJB5 (34989638 - 34998897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DNAJB5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6527CNV Insertion18451855
    esv999515CNV Loss20482838
    nsv893043CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611328    OMIM disorders: --


    Find genes that share disorders with DNAJB5           About GenesLikeMe


    Export disorders for DNAJB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJB5 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with DNAJB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. (PubMed id 10570961)1, 2, 3 Chen M.-S.... Laszlo A. (Gene 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    7. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. (PubMed id 18555775)1 Ago T....Sadoshima J. (Cell 2008)
    8. Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. (PubMed id 18457437)1 Forsman A....Rymo L. (J. Proteome Res. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination. (PubMed id 15456869)1 Huang Z....Sun X.H. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25822 HGNC: 14887 AceView: DNAJB5 Ensembl:ENSG00000137094 euGenes: HUgn25822
    ECgene: DNAJB5 H-InvDB: DNAJB5

    (According to HUGE)
    About This Section

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    HUGE: KIAA1045

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJB5 gene:
    Search GeneIP for patents involving DNAJB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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