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Aliases for DNAJB5 Gene

Aliases for DNAJB5 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B5 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 5 2 3
  • Heat Shock Protein Cognate 40 3 4
  • Heat Shock Protein Hsp40-2 3 4
  • Heat Shock Protein Hsp40-3 3 4
  • Hsc40 3 4
  • Heat Shock Cognate 40 3

External Ids for DNAJB5 Gene

Previous GeneCards Identifiers for DNAJB5 Gene

  • GC09P035301
  • GC09P035159
  • GC09P034979
  • GC09P034990
  • GC09P034944

Summaries for DNAJB5 Gene

Entrez Gene Summary for DNAJB5 Gene

  • DNAJB5 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ family, see MIM 608375.[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJB5 Gene

DNAJB5 (DnaJ Heat Shock Protein Family (Hsp40) Member B5) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB5 Gene

Genomics for DNAJB5 Gene

Regulatory Elements for DNAJB5 Gene

Promoters for DNAJB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJB5 Gene

Chromosome:
9
Start:
34,989,369 bp from pter
End:
34,998,900 bp from pter
Size:
9,532 bases
Orientation:
Plus strand

Genomic View for DNAJB5 Gene

Genes around DNAJB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB5 Gene

Proteins for DNAJB5 Gene

  • Protein details for DNAJB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75953-DNJB5_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 5
    Protein Accession:
    O75953
    Secondary Accessions:
    • B3KN14
    • B4DSA6
    • J3KQM9
    • J3KR08
    • Q5T656
    • Q8TDR7
    • Q96EM4

    Protein attributes for DNAJB5 Gene

    Size:
    348 amino acids
    Molecular mass:
    39133 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12115.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB5 Gene

Proteomics data for DNAJB5 Gene at MOPED

Post-translational modifications for DNAJB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJB5 Gene

Domains & Families for DNAJB5 Gene

Gene Families for DNAJB5 Gene

Protein Domains for DNAJB5 Gene

Suggested Antigen Peptide Sequences for DNAJB5 Gene

Graphical View of Domain Structure for InterPro Entry

O75953

UniProtKB/Swiss-Prot:

DNJB5_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB5: view

Function for DNAJB5 Gene

Molecular function for DNAJB5 Gene

UniProtKB/Swiss-Prot Induction:
Expressed under normal conditions, its expression can further be increased after various stress treatments.
genes like me logo Genes that share phenotypes with DNAJB5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB5 Gene

Localization for DNAJB5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB5 Gene COMPARTMENTS Subcellular localization image for DNAJB5 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJB5 Gene

Pathways & Interactions for DNAJB5 Gene

SuperPathways for DNAJB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB5 Gene

Drugs & Compounds for DNAJB5 Gene

No Compound Related Data Available

Transcripts for DNAJB5 Gene

Unigene Clusters for DNAJB5 Gene

DnaJ (Hsp40) homolog, subfamily B, member 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for DNAJB5 Gene

GeneLoc Exon Structure for
DNAJB5
ECgene alternative splicing isoforms for
DNAJB5

Expression for DNAJB5 Gene

mRNA expression in normal human tissues for DNAJB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB5 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for DNAJB5 Gene

This gene is overexpressed in Colon (13.7), Urinary Bladder (11.8), Breast (10.2), Cardia (7.5), Prostate (7.5), and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB5 Gene



SOURCE GeneReport for Unigene cluster for DNAJB5 Gene Hs.237506

genes like me logo Genes that share expression patterns with DNAJB5: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DNAJB5 Gene

Orthologs for DNAJB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB5 36
  • 98 (a)
OneToOne
DNAJB5 35
  • 99.57 (n)
  • 99.78 (a)
cow
(Bos Taurus)
Mammalia DNAJB5 36
  • 99 (a)
OneToOne
DNAJB5 35
  • 93.77 (n)
  • 99.14 (a)
dog
(Canis familiaris)
Mammalia DNAJB5 35
  • 94.73 (n)
  • 97.19 (a)
DNAJB5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb5 16
Dnajb5 36
  • 99 (a)
OneToOne
Dnajb5 35
  • 93.49 (n)
  • 99.14 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJB5 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB5 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb5 35
  • 93.63 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves DNAJB5 35
  • 78.3 (n)
  • 85.56 (a)
DNAJB5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB5 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb5 35
  • 77.81 (n)
  • 81.27 (a)
Str.18193 35
zebrafish
(Danio rerio)
Actinopterygii dnajb5 36
  • 75 (a)
OneToOne
dnajb5 35
  • 71.46 (n)
  • 76.72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010239 35
  • 54.91 (n)
  • 54.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2887 37
  • 37 (a)
CG5001 37
  • 50 (a)
DnaJ-1 37
  • 50 (a)
CG2887 36
  • 43 (a)
ManyToMany
CG5001 36
  • 53 (a)
ManyToMany
DnaJ-1 36
  • 52 (a)
ManyToMany
CG5001 35
  • 57.07 (n)
  • 53.78 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-13 36
  • 56 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.1940 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20560 35
  • 53.17 (n)
  • 44.24 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3521 35
rice
(Oryza sativa)
Liliopsida Os.35463 35
Os05g0562300 35
  • 57.14 (n)
  • 47.72 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9254 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for DNAJB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB5 Gene

ENSEMBL:
Gene Tree for DNAJB5 (if available)
TreeFam:
Gene Tree for DNAJB5 (if available)

Paralogs for DNAJB5 Gene

Pseudogenes.org Pseudogenes for DNAJB5 Gene

genes like me logo Genes that share paralogs with DNAJB5: view

Variants for DNAJB5 Gene

Sequence variations from dbSNP and Humsavar for DNAJB5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3780731 -- 34,995,454(-) TGGCA(G/T)TGGTG intron-variant
rs3780732 -- 34,992,949(-) TGTGG(C/T)CCACT intron-variant, utr-variant-5-prime
rs4879848 -- 34,992,077(+) AAGTC(G/T)CAGAA intron-variant, upstream-variant-2KB
rs4879849 -- 34,996,017(+) CCTGG(A/C)TTTTC intron-variant
rs11555365 -- 34,998,339(-) TCAAA(G/T)TGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJB5 Gene

Variant ID Type Subtype PubMed ID
nsv893043 CNV Gain 21882294
nsv6527 CNV Insertion 18451855
esv999515 CNV Loss 20482838

Variation tolerance for DNAJB5 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB5 Gene

HapMap Linkage Disequilibrium report
DNAJB5
Human Gene Mutation Database (HGMD)
DNAJB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB5 Gene

Disorders for DNAJB5 Gene

Relevant External Links for DNAJB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB5

No disorders were found for DNAJB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB5 Gene

Publications for DNAJB5 Gene

  1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. (PMID: 10570961) Chen M.-S. … Laszlo A. (Gene 1999) 2 3 4 67
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for DNAJB5 Gene

Sources for DNAJB5 Gene

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