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Aliases for DNAJB5 Gene

Aliases for DNAJB5 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B5 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 5 2 3
  • Heat Shock Protein Cognate 40 3 4
  • Heat Shock Protein Hsp40-2 3 4
  • Heat Shock Protein Hsp40-3 3 4
  • Hsc40 3 4
  • DnaJ Homolog Subfamily B Member 5 3
  • Heat Shock Cognate 40 3

External Ids for DNAJB5 Gene

Previous GeneCards Identifiers for DNAJB5 Gene

  • GC09P035301
  • GC09P035159
  • GC09P034979
  • GC09P034990
  • GC09P034944

Summaries for DNAJB5 Gene

Entrez Gene Summary for DNAJB5 Gene

  • DNAJB5 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ family, see MIM 608375.[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJB5 Gene

DNAJB5 (DnaJ Heat Shock Protein Family (Hsp40) Member B5) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB5 Gene

Genomics for DNAJB5 Gene

Regulatory Elements for DNAJB5 Gene

Enhancers for DNAJB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F035025 1.2 Ensembl ENCODE 11.7 +37.9 37904 4.1 ATF1 CBX3 PKNOX1 PTRF ZNF766 CREM JUNB ZEB2 REST HDAC8 FANCG CCDC107 PIGO TPM2 DNAJB5 SPAG8 PHF24 STOML2 ENSG00000234181 CREB3
GH09F035023 0.8 Ensembl 11.7 +34.1 34133 0.6 LEF1 TAL1 ETV1 NCOR1 TRIM24 SMARCE1 MTA2 RNF2 ZBTB2 L3MBTL2 DNAJB5 PHF24 STOML2 ENSG00000234181 PIGO VCP LOC105376025 SYF2P2
GH09F035904 1.6 FANTOM5 Ensembl ENCODE 4.6 +918.7 918732 7.8 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 FOS ZNF263 SP3 REST HRCT1 LINC00961 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09F034575 1.2 FANTOM5 Ensembl ENCODE 4.6 -411.1 -411142 5.1 ZNF263 CTCF RNF2 CBX2 REST ZFHX2 JUND ZNF366 POLR2A ZNF341 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR ENSG00000230729 SIGMAR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB5 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302719 431 2801 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A YY1 GLIS2 ZNF207 ZNF143 FOS

Genomic Location for DNAJB5 Gene

34,989,369 bp from pter
34,998,900 bp from pter
9,532 bases
Plus strand

Genomic View for DNAJB5 Gene

Genes around DNAJB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB5 Gene

Proteins for DNAJB5 Gene

  • Protein details for DNAJB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 5
    Protein Accession:
    Secondary Accessions:
    • B3KN14
    • B4DSA6
    • J3KQM9
    • J3KR08
    • Q5T656
    • Q8TDR7
    • Q96EM4

    Protein attributes for DNAJB5 Gene

    348 amino acids
    Molecular mass:
    39133 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12115.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB5 Gene


neXtProt entry for DNAJB5 Gene

Post-translational modifications for DNAJB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJB5 Gene

Domains & Families for DNAJB5 Gene

Gene Families for DNAJB5 Gene

Protein Domains for DNAJB5 Gene

Suggested Antigen Peptide Sequences for DNAJB5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB5: view

Function for DNAJB5 Gene

Molecular function for DNAJB5 Gene

UniProtKB/Swiss-Prot Induction:
Expressed under normal conditions, its expression can further be increased after various stress treatments.

Gene Ontology (GO) - Molecular Function for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18457437
GO:0051082 unfolded protein binding IEA --
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB5: view
genes like me logo Genes that share phenotypes with DNAJB5: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB5 Gene

Localization for DNAJB5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB5 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3

Gene Ontology (GO) - Cellular Components for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJB5 Gene

Pathways & Interactions for DNAJB5 Gene

SuperPathways for DNAJB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein IEP 10570961
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB5 Gene

Transcripts for DNAJB5 Gene

Unigene Clusters for DNAJB5 Gene

DnaJ (Hsp40) homolog, subfamily B, member 5:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - -
SP8: -

Relevant External Links for DNAJB5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB5 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for DNAJB5 Gene

This gene is overexpressed in Colon (13.7), Urinary Bladder (11.8), Breast (10.2), Cardia (7.5), Prostate (7.5), and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJB5 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB5 Gene:

genes like me logo Genes that share expression patterns with DNAJB5: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DNAJB5 Gene

Orthologs for DNAJB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJB5 34 35
  • 99.57 (n)
(Monodelphis domestica)
Mammalia DNAJB5 35
  • 95 (a)
(Canis familiaris)
Mammalia DNAJB5 34 35
  • 94.73 (n)
(Bos Taurus)
Mammalia DNAJB5 34 35
  • 93.77 (n)
(Rattus norvegicus)
Mammalia Dnajb5 34
  • 93.63 (n)
(Mus musculus)
Mammalia Dnajb5 34 16 35
  • 93.49 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJB5 35
  • 76 (a)
(Gallus gallus)
Aves DNAJB5 34 35
  • 78.3 (n)
(Anolis carolinensis)
Reptilia DNAJB5 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb5 34
  • 77.81 (n)
Str.18193 34
(Danio rerio)
Actinopterygii dnajb5 34 35
  • 71.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5001 36 34 35
  • 57.07 (n)
DnaJ-1 36 35
  • 50 (a)
CG2887 36 35
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010239 34
  • 54.91 (n)
(Caenorhabditis elegans)
Secernentea dnj-13 35
  • 56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20560 34
  • 53.17 (n)
(Glycine max)
eudicotyledons Gma.1940 34
(Oryza sativa)
Liliopsida Os05g0562300 34
  • 57.14 (n)
Os.35463 34
(Hordeum vulgare)
Liliopsida Hv.3521 34
(Triticum aestivum)
Liliopsida Ta.9254 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
Species where no ortholog for DNAJB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB5 Gene

Gene Tree for DNAJB5 (if available)
Gene Tree for DNAJB5 (if available)

Paralogs for DNAJB5 Gene

Variants for DNAJB5 Gene

Sequence variations from dbSNP and Humsavar for DNAJB5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs774909609 Likely pathogenic 34,990,673(+) CAGCA(C/T)CCCCA intron-variant, upstream-variant-2KB, reference, missense
rs10123871 -- 34,989,163(+) CCTTT(C/T)GGCCC nc-transcript-variant, upstream-variant-2KB
rs1052641 -- 34,998,245(+) ATCCC(A/C)CCCCA utr-variant-3-prime
rs10647225 -- 34,988,091(+) TCATG(-/CTC)CTCAT intron-variant, upstream-variant-2KB
rs111414243 -- 34,996,056(+) ATCTC(A/C)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB5 Gene

Variant ID Type Subtype PubMed ID
nsv972665 CNV duplication 23825009
nsv6527 CNV insertion 18451855
nsv1125318 OTHER inversion 24896259
nsv1077101 CNV deletion 25765185
esv999515 CNV loss 20482838

Variation tolerance for DNAJB5 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB5 Gene

Disorders for DNAJB5 Gene

Relevant External Links for DNAJB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNAJB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB5 Gene

Publications for DNAJB5 Gene

  1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. (PMID: 10570961) Chen M.-S. … Laszlo A. (Gene 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for DNAJB5 Gene

Sources for DNAJB5 Gene

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