Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJB5 Gene

Aliases for DNAJB5 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B5 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 5 2 3
  • Heat Shock Protein Cognate 40 3 4
  • Heat Shock Protein Hsp40-2 3 4
  • Heat Shock Protein Hsp40-3 3 4
  • Hsc40 3 4
  • DnaJ Homolog Subfamily B Member 5 3
  • Heat Shock Cognate 40 3

External Ids for DNAJB5 Gene

Previous GeneCards Identifiers for DNAJB5 Gene

  • GC09P035301
  • GC09P035159
  • GC09P034979
  • GC09P034990
  • GC09P034944

Summaries for DNAJB5 Gene

Entrez Gene Summary for DNAJB5 Gene

  • This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]

GeneCards Summary for DNAJB5 Gene

DNAJB5 (DnaJ Heat Shock Protein Family (Hsp40) Member B5) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB4.

Additional gene information for DNAJB5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB5 Gene

Genomics for DNAJB5 Gene

Regulatory Elements for DNAJB5 Gene

Enhancers for DNAJB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H035025 1.1 Ensembl ENCODE 11.7 +37.9 37904 4 PKNOX1 ATF1 TCF12 ZNF766 CREM CAVIN1 REST ZEB2 HDAC8 ZNF592 PIGO FANCG TMEM8B DNAJB5 ENSG00000230074 SPAG8 PHF24 STOML2 ENSG00000234181 CREB3
GH09H034987 1.6 FANTOM5 ENCODE dbSUPER 7.1 +3.9 3911 10 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS DEK SP3 VCP UBAP2 ARHGEF39 TPM2 FANCG CCDC107 TLN1 YBX1P10 PIGO FAM205A
GH09H035904 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +918.8 918799 7 FOXA2 YY1 ZNF121 ZNF143 FOS DEK SP3 REST PPARG ZNF518A HRCT1 SPAAR TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09H034700 1.2 Ensembl ENCODE 4.4 -287.5 -287450 1 ARID4B ZNF76 KLF17 ZNF2 ZBTB7B RAD21 YY1 ELK1 EGR1 ZNF366 TPM2 CCDC107 ARHGEF39 RPP25L DNAJB5 CCL21 CCL19
GH09H034575 0.9 FANTOM5 ENCODE 4.6 -411.1 -411142 5 REST JUND ZFHX2 ZNF366 POLR2A ZNF341 EGR2 EZH2 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR ENSG00000230729 SIGMAR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB5 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234587 231 1601 PKNOX1 ATF1 ARID4B SIN3A YY1 GLIS2 ZNF207 ZNF143 ATF7 FOS

Genomic Location for DNAJB5 Gene

Chromosome:
9
Start:
34,989,369 bp from pter
End:
34,998,900 bp from pter
Size:
9,532 bases
Orientation:
Plus strand

Genomic View for DNAJB5 Gene

Genes around DNAJB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB5 Gene

Proteins for DNAJB5 Gene

  • Protein details for DNAJB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75953-DNJB5_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 5
    Protein Accession:
    O75953
    Secondary Accessions:
    • B3KN14
    • B4DSA6
    • J3KQM9
    • J3KR08
    • Q5T656
    • Q8TDR7
    • Q96EM4

    Protein attributes for DNAJB5 Gene

    Size:
    348 amino acids
    Molecular mass:
    39133 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12115.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB5 Gene

Post-translational modifications for DNAJB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJB5 Gene

Domains & Families for DNAJB5 Gene

Gene Families for DNAJB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJB5 Gene

Suggested Antigen Peptide Sequences for DNAJB5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB5: view

No data available for UniProtKB/Swiss-Prot for DNAJB5 Gene

Function for DNAJB5 Gene

Molecular function for DNAJB5 Gene

UniProtKB/Swiss-Prot Induction:
Expressed under normal conditions, its expression can further be increased after various stress treatments.

Phenotypes From GWAS Catalog for DNAJB5 Gene

Gene Ontology (GO) - Molecular Function for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18457437
GO:0051082 unfolded protein binding IEA --
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB5: view
genes like me logo Genes that share phenotypes with DNAJB5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJB5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB5 Gene

Localization for DNAJB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB5 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJB5 Gene

Pathways & Interactions for DNAJB5 Gene

SuperPathways for DNAJB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein IEP 10570961
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB5 Gene

Drugs & Compounds for DNAJB5 Gene

No Compound Related Data Available

Transcripts for DNAJB5 Gene

Unigene Clusters for DNAJB5 Gene

DnaJ (Hsp40) homolog, subfamily B, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJB5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for DNAJB5 Gene

GeneLoc Exon Structure for
DNAJB5
ECgene alternative splicing isoforms for
DNAJB5

Expression for DNAJB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB5 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for DNAJB5 Gene

This gene is overexpressed in Colon (13.7), Urinary Bladder (11.8), Breast (10.2), Cardia (7.5), Prostate (7.5), and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB5 Gene



NURSA nuclear receptor signaling pathways regulating expression of DNAJB5 Gene:

DNAJB5

SOURCE GeneReport for Unigene cluster for DNAJB5 Gene:

Hs.237506

Evidence on tissue expression from TISSUES for DNAJB5 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Skin(4.1)
  • Muscle(2.8)
genes like me logo Genes that share expression patterns with DNAJB5: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB5 Gene

Orthologs for DNAJB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB5 33 34
  • 99.57 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJB5 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB5 33 34
  • 94.73 (n)
cow
(Bos Taurus)
Mammalia DNAJB5 33 34
  • 93.77 (n)
rat
(Rattus norvegicus)
Mammalia Dnajb5 33
  • 93.63 (n)
mouse
(Mus musculus)
Mammalia Dnajb5 33 16 34
  • 93.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB5 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB5 33 34
  • 78.3 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJB5 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb5 33
  • 77.81 (n)
Str.18193 33
zebrafish
(Danio rerio)
Actinopterygii dnajb5 33 34
  • 71.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5001 35 33 34
  • 57.07 (n)
DnaJ-1 35 34
  • 50 (a)
CG2887 35 34
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010239 33
  • 54.91 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-13 34
  • 56 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20560 33
  • 53.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.1940 33
rice
(Oryza sativa)
Liliopsida Os05g0562300 33
  • 57.14 (n)
Os.35463 33
barley
(Hordeum vulgare)
Liliopsida Hv.3521 33
wheat
(Triticum aestivum)
Liliopsida Ta.9254 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToMany
Species where no ortholog for DNAJB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB5 Gene

ENSEMBL:
Gene Tree for DNAJB5 (if available)
TreeFam:
Gene Tree for DNAJB5 (if available)

Paralogs for DNAJB5 Gene

Variants for DNAJB5 Gene

Sequence variations from dbSNP and Humsavar for DNAJB5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs774909609 Likely pathogenic 34,990,673(+) CAGCA(C/T)CCCCA intron-variant, upstream-variant-2KB, reference, missense
rs1000233810 -- 34,987,806(+) CCTCA(-/CTC)CTCCT intron-variant, upstream-variant-2KB
rs1000289376 -- 34,997,714(+) TCCAC(A/G)GTGTC utr-variant-3-prime
rs1000403034 -- 34,992,708(+) GCTGG(C/T)GGAAG intron-variant, upstream-variant-2KB
rs1000835903 -- 34,989,195(+) CAGAG(C/T)GCACT nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJB5 Gene

Variant ID Type Subtype PubMed ID
esv999515 CNV loss 20482838
nsv1077101 CNV deletion 25765185
nsv1125318 OTHER inversion 24896259
nsv6527 CNV insertion 18451855
nsv972665 CNV duplication 23825009

Variation tolerance for DNAJB5 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB5 Gene

Human Gene Mutation Database (HGMD)
DNAJB5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB5 Gene

Disorders for DNAJB5 Gene

Relevant External Links for DNAJB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB5

No disorders were found for DNAJB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB5 Gene

Publications for DNAJB5 Gene

  1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. (PMID: 10570961) Chen MS … Laszlo A (Gene 1999) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for DNAJB5 Gene

Sources for DNAJB5 Gene

Content
Loading form....