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Aliases for DNAJB4 Gene

Aliases for DNAJB4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B4 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 4 2 3
  • Heat Shock 40 KDa Protein 1 Homolog 3 4
  • Heat Shock Protein 40 Homolog 3 4
  • Human Liver DnaJ-Like Protein 3 4
  • HSP40 Homolog 3 4
  • DNAJW 3 4
  • HLJ1 3 4
  • DnaJ-Like Heat Shock Protein 40 3
  • DjB4 3

External Ids for DNAJB4 Gene

Previous GeneCards Identifiers for DNAJB4 Gene

  • GC01P078623
  • GC01P077417
  • GC01P077835
  • GC01P077893
  • GC01P078182
  • GC01P078444
  • GC01P076602

Summaries for DNAJB4 Gene

Entrez Gene Summary for DNAJB4 Gene

  • The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for DNAJB4 Gene

DNAJB4 (DnaJ Heat Shock Protein Family (Hsp40) Member B4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB4 Gene

  • Probable chaperone.

Gene Wiki entry for DNAJB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB4 Gene

Genomics for DNAJB4 Gene

Regulatory Elements for DNAJB4 Gene

Enhancers for DNAJB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJB4 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJB4 Gene

Chromosome:
1
Start:
77,979,175 bp from pter
End:
78,018,721 bp from pter
Size:
39,547 bases
Orientation:
Plus strand

Genomic View for DNAJB4 Gene

Genes around DNAJB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB4 Gene

Proteins for DNAJB4 Gene

  • Protein details for DNAJB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDY4-DNJB4_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 4
    Protein Accession:
    Q9UDY4
    Secondary Accessions:
    • B2R824
    • Q13431

    Protein attributes for DNAJB4 Gene

    Size:
    337 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    • Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.

neXtProt entry for DNAJB4 Gene

Proteomics data for DNAJB4 Gene at MOPED

Post-translational modifications for DNAJB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB4 Gene

No data available for DME Specific Peptides for DNAJB4 Gene

Domains & Families for DNAJB4 Gene

Gene Families for DNAJB4 Gene

Protein Domains for DNAJB4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDY4

UniProtKB/Swiss-Prot:

DNJB4_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB4: view

Function for DNAJB4 Gene

Molecular function for DNAJB4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone.
UniProtKB/Swiss-Prot Induction:
By heat shock.
genes like me logo Genes that share phenotypes with DNAJB4: view

Animal Model Products

miRNA for DNAJB4 Gene

miRTarBase miRNAs that target DNAJB4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB4 Gene

Localization for DNAJB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB4 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB4 Gene COMPARTMENTS Subcellular localization image for DNAJB4 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DNAJB4: view

Pathways & Interactions for DNAJB4 Gene

SuperPathways for DNAJB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009408 response to heat TAS 9546042
genes like me logo Genes that share ontologies with DNAJB4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB4 Gene

Drugs & Compounds for DNAJB4 Gene

No Compound Related Data Available

Transcripts for DNAJB4 Gene

Unigene Clusters for DNAJB4 Gene

DnaJ (Hsp40) homolog, subfamily B, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DNAJB4 Gene

GeneLoc Exon Structure for
DNAJB4
ECgene alternative splicing isoforms for
DNAJB4

Expression for DNAJB4 Gene

mRNA expression in normal human tissues for DNAJB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJB4 Gene

This gene is overexpressed in Rectum (7.3), Urinary Bladder (6.7), and Prostate (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB4 Gene



SOURCE GeneReport for Unigene cluster for DNAJB4 Gene Hs.13852

mRNA Expression by UniProt/SwissProt for DNAJB4 Gene

Q9UDY4-DNJB4_HUMAN
Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
genes like me logo Genes that share expression patterns with DNAJB4: view

Protein tissue co-expression partners for DNAJB4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DNAJB4 Gene

Orthologs for DNAJB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJB4 35
  • 94.56 (n)
  • 96.14 (a)
DNAJB4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB4 35
  • 95.65 (n)
  • 96.74 (a)
DNAJB4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb4 35
  • 90.5 (n)
  • 94.07 (a)
Dnajb4 16
Dnajb4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJB4 35
  • 100 (n)
  • 100 (a)
DNAJB4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb4 35
  • 88.53 (n)
  • 95.55 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJB4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB4 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB4 35
  • 79.72 (n)
  • 83.98 (a)
DNAJB4 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb4 35
  • 75.66 (n)
  • 81.58 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajb4 35
  • 67.26 (n)
  • 71.13 (a)
dnajb4 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12020 37
  • 28 (a)
CG2887 37
  • 44 (a)
CG5001 37
  • 50 (a)
DnaJ-1 37
  • 55 (a)
DnaJ-1 35
  • 55.9 (n)
  • 59.63 (a)
CG2887 36
  • 45 (a)
ManyToMany
CG5001 36
  • 52 (a)
ManyToMany
DnaJ-1 36
  • 54 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007107 35
  • 54.82 (n)
  • 61.75 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-13 35
  • 55.38 (n)
  • 56 (a)
dnj-13 36
  • 54 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25530 35
  • 50.61 (n)
  • 46.06 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7032 35
rice
(Oryza sativa)
Liliopsida Os02g0128400 35
  • 47.41 (n)
  • 41.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for DNAJB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB4 Gene

ENSEMBL:
Gene Tree for DNAJB4 (if available)
TreeFam:
Gene Tree for DNAJB4 (if available)

Paralogs for DNAJB4 Gene

genes like me logo Genes that share paralogs with DNAJB4: view

Variants for DNAJB4 Gene

Sequence variations from dbSNP and Humsavar for DNAJB4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1135610 -- 77,997,225(+) ctgta(A/G)tccca intron-variant
rs1135611 -- 77,997,231(+) tccca(A/G)cactg intron-variant
rs1039863 -- 78,015,956(-) AAGCA(C/T)AAATT intron-variant
rs1047451 -- 78,016,351(+) AAATT(C/G)TTTTG utr-variant-3-prime
rs1964711 -- 78,015,827(-) tcaca(C/T)ctgta intron-variant

Variation tolerance for DNAJB4 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DNAJB4 Gene

Disorders for DNAJB4 Gene

Relevant External Links for DNAJB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB4

No disorders were found for DNAJB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB4 Gene

Publications for DNAJB4 Gene

  1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PMID: 9546042) Hoe K.L. … Yoo H.S. (Biochim. Biophys. Acta 1998) 2 3 4 23 67
  2. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. (PMID: 16788156) Tsai M.F. … Yang P.C. (J. Natl. Cancer Inst. 2006) 3 23
  3. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. (PMID: 15782117) Wang C.C. … Yang P.C. (Oncogene 2005) 3 23
  4. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DNAJB4 Gene

Sources for DNAJB4 Gene

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