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Aliases for DNAJB4 Gene

Aliases for DNAJB4 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 4 2 3
  • Heat Shock 40 KDa Protein 1 Homolog 3 4
  • Heat Shock Protein 40 Homolog 3 4
  • Human Liver DnaJ-Like Protein 3 4
  • HSP40 Homolog 3 4
  • DNAJW 3 4
  • HLJ1 3 4
  • DnaJ Homolog Subfamily B Member 4 3
  • DnaJ-Like Heat Shock Protein 40 3
  • DjB4 3

External Ids for DNAJB4 Gene

Previous GeneCards Identifiers for DNAJB4 Gene

  • GC01P078623
  • GC01P077417
  • GC01P077835
  • GC01P078182
  • GC01P078444
  • GC01P076602

Summaries for DNAJB4 Gene

Entrez Gene Summary for DNAJB4 Gene

  • DNAJB4 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ family, see MIM 608375.[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJB4 Gene

DNAJB4 (DnaJ (Hsp40) Homolog, Subfamily B, Member 4) is a Protein Coding gene. Diseases associated with DNAJB4 include oculopharyngeal muscular dystrophy. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB4 Gene

  • Probable chaperone

Gene Wiki entry for DNAJB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB4 Gene

Genomics for DNAJB4 Gene

Regulatory Elements for DNAJB4 Gene

Genomic Location for DNAJB4 Gene

77,979,163 bp from pter
78,017,964 bp from pter
38,802 bases
Plus strand

Genomic View for DNAJB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB4 Gene

Proteins for DNAJB4 Gene

  • Protein details for DNAJB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 4
    Protein Accession:
    Secondary Accessions:
    • B2R824
    • Q13431

    Protein attributes for DNAJB4 Gene

    337 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    • Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.

neXtProt entry for DNAJB4 Gene

Proteomics data for DNAJB4 Gene at MOPED

Post-translational modifications for DNAJB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJB4 Gene

Domains for DNAJB4 Gene

Gene Families for DNAJB4 Gene

Protein Domains for DNAJB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB4: view

Function for DNAJB4 Gene

Molecular function for DNAJB4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21255413
GO:0051082 unfolded protein binding IEA --
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB4: view

Phenotypes for DNAJB4 Gene

genes like me logo Genes that share phenotypes with DNAJB4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB4 Gene

Localization for DNAJB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB4 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Subcellular locations from

Jensen Localization Image for DNAJB4 Gene COMPARTMENTS Subcellular localization image for DNAJB4 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 21231916
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with DNAJB4: view

Pathways for DNAJB4 Gene

SuperPathways for DNAJB4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat
    • Cellular Stress Responses in human,mouse,rat

Gene Ontology (GO) - Biological Process for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein TAS 9546042
GO:0009408 response to heat TAS 9546042
genes like me logo Genes that share ontologies with DNAJB4: view

No data available for Pathways by source for DNAJB4 Gene

Transcripts for DNAJB4 Gene

Unigene Clusters for DNAJB4 Gene

DnaJ (Hsp40) homolog, subfamily B, member 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for DNAJB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB4 Gene

mRNA expression in normal human tissues for DNAJB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DNAJB4 Gene

This gene is overexpressed in Rectum (7.3), Urinary Bladder (6.7), and Prostate (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB4 Gene

SOURCE GeneReport for Unigene cluster for DNAJB4 Gene Hs.13852

mRNA Expression by UniProt/SwissProt for DNAJB4 Gene

Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
genes like me logo Genes that share expressions with DNAJB4: view

Expression partners for DNAJB4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DNAJB4 Gene

Orthologs for DNAJB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJB4 35
  • 94.56 (n)
  • 96.14 (a)
  • 96 (a)
(Canis familiaris)
Mammalia DNAJB4 35
  • 95.65 (n)
  • 96.74 (a)
  • 97 (a)
(Mus musculus)
Mammalia Dnajb4 35
  • 90.5 (n)
  • 94.07 (a)
Dnajb4 16
Dnajb4 36
  • 94 (a)
(Pan troglodytes)
Mammalia DNAJB4 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajb4 35
  • 88.53 (n)
  • 95.55 (a)
(Monodelphis domestica)
Mammalia DNAJB4 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJB4 36
  • 86 (a)
(Gallus gallus)
Aves DNAJB4 35
  • 79.72 (n)
  • 83.98 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia DNAJB4 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb4 35
  • 75.66 (n)
  • 81.58 (a)
(Danio rerio)
Actinopterygii dnajb4 35
  • 67.26 (n)
  • 71.13 (a)
dnajb4 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12020 37
  • 28 (a)
CG2887 37
  • 44 (a)
CG5001 37
  • 50 (a)
DnaJ-1 37
  • 55 (a)
DnaJ-1 35
  • 55.9 (n)
  • 59.63 (a)
CG2887 36
  • 45 (a)
CG5001 36
  • 52 (a)
DnaJ-1 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007107 35
  • 54.82 (n)
  • 61.75 (a)
(Caenorhabditis elegans)
Secernentea dnj-13 35
  • 55.38 (n)
  • 56 (a)
dnj-13 36
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25530 35
  • 50.61 (n)
  • 46.06 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7032 35
(Oryza sativa)
Liliopsida Os02g0128400 35
  • 47.41 (n)
  • 41.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for DNAJB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB4 Gene

Gene Tree for DNAJB4 (if available)
Gene Tree for DNAJB4 (if available)

Paralogs for DNAJB4 Gene

genes like me logo Genes that share paralogs with DNAJB4: view

Variants for DNAJB4 Gene

Sequence variations from dbSNP and Humsavar for DNAJB4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1039863 -- 78,015,956(-) AAGCA(C/T)AAATT intron-variant
rs1047451 -- 78,016,351(+) AAATT(C/G)TTTTG utr-variant-3-prime
rs1135610 -- 77,997,225(+) ctgta(A/G)tccca intron-variant
rs1135611 -- 77,997,231(+) tccca(A/G)cactg intron-variant
rs1964711 -- 78,015,827(-) tcaca(C/T)ctgta intron-variant

Relevant External Links for DNAJB4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJB4 Gene

Disorders for DNAJB4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNAJB4 Gene in MalaCards »

(1) Disease for DNAJB4 Gene

genes like me logo Genes that share disorders with DNAJB4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DNAJB4 Gene

Publications for DNAJB4 Gene

  1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PMID: 9546042) Hoe K.L. … Yoo H.S. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. (PMID: 15782117) Wang C.C. … Yang P.C. (Oncogene 2005) 3 23
  3. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. (PMID: 16788156) Tsai M.F. … Yang P.C. (J. Natl. Cancer Inst. 2006) 3 23
  4. Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen. (PMID: 18837411) Lin X. … Wang X. (Sheng Wu Gong Cheng Xue Bao 2008) 4 23
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3

Products for DNAJB4 Gene

Sources for DNAJB4 Gene

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