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DNAJB4 Gene

protein-coding   GIFtS: 54
GCID: GC01P078444

DnaJ (Hsp40) Homolog, Subfamily B, Member 4

  See DNAJB4-related disease
at
MalaCards
 

Aliases
for DNAJB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 41 2     HLJ12 3
Heat Shock 40 KDa Protein 1 Homolog2 3     HSP40 Homolog2 3
Heat Shock Protein 40 Homolog2 3     DjB42
Human Liver DnaJ-Like Protein2 3     DnaJ Homolog Subfamily B Member 42
DNAJW2 3     DnaJ-Like Heat Shock Protein 402

External Ids:    HGNC: 148861   Entrez Gene: 110802   Ensembl: ENSG000001626167   OMIM: 6113275   UniProtKB: Q9UDY43   

Export aliases for DNAJB4 gene to outside databases

Previous GC identifers: GC01P078623 GC01P077417 GC01P077835 GC01P077893 GC01P078182 GC01P076602


Summaries
for DNAJB4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJB4 Gene:
DNAJB4 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ
family, see MIM 608375.(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAJB4 Gene:
DNAJB4 (DnaJ (Hsp40) homolog, subfamily B, member 4) is a protein-coding gene. Diseases associated with DNAJB4 include oculopharyngeal muscular dystrophy. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJB5.

UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4
Function: Probable chaperone

Gene Wiki entry for DNAJB4 Gene


Genomic Views
for DNAJB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJB4 gene promoter:
         Sox5   AML1a   AP-1   ATF-2   STAT3   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNAJB4 promoter sequence
   Search Chromatin IP Primers for DNAJB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P078444:  view genomic region     (about GC identifiers)

Start:
 78,444,859 bp from pter      End:
 78,483,648 bp from pter
Size:
 38,790 bases      Orientation:
 plus strand

Proteins
for DNAJB4 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 4  
Size: 337 amino acids; 37807 Da
Subunit: Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1
Secondary accessions: B2R824 Q13431

Explore the universe of human proteins at neXtProt for DNAJB4: NX_Q9UDY4

Explore proteomics data for DNAJB4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See DNAJB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008965.2  
    ENSEMBL proteins: 
     ENSP00000399494   ENSP00000359799  

    DNAJB4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DNAJB4
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for DNAJB4
    OriGene Custom Protein Services for DNAJB4
    GenScript Custom Purified and Recombinant Proteins Services for DNAJB4
    Novus Biologicals DNAJB4 Proteins
    Novus Biologicals DNAJB4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DNAJB4
    Cloud-Clone Corp. Proteins for DNAJB4

         		 Search eBioscience for Proteins for DNAJB4 

         		antibodies-online proteins for DNAJB4 (8 products) 

         		antibodies-online peptides for DNAJB4

    DNAJB4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals DNAJB4 Antibodies
    Abcam antibodies for DNAJB4
    Cloud-Clone Corp. Antibodies for DNAJB4
    Search ThermoFisher Antibodies for DNAJB4
    antibodies-online antibodies for DNAJB4 (42 products) 

    DNAJB4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNAJB4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNAJB4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNAJB4
    Cloud-Clone Corp. CLIAs for DNAJB4
    Search eBioscience for ELISAs for DNAJB4 
    antibodies-online kits for DNAJB4 (6 products) 

    Domains /
    Families
    for DNAJB4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q9UDY4

    ProtoNet protein and cluster: Q9UDY4

    UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJB4           About GenesLikeMe


    Function
    for DNAJB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJB4_HUMAN, Q9UDY4
    Function: Probable chaperone
    Induction: By heat shock

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with DNAJB4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DNAJB4:
     Increased gamma-H2AX phosphory  Increased homologous recombina  Lamellipodia cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DNAJB4

    miRNA
    Products:            		miRTarBase miRNAs that target DNAJB4:
    hsa-mir-148a-3p (MIRT026002), hsa-mir-142-3p (MIRT021629), hsa-mir-148b-3p (MIRT019300), hsa-mir-215-5p (MIRT024618), hsa-mir-30a-5p (MIRT028464), hsa-mir-16-5p (MIRT001471), hsa-mir-26b-5p (MIRT028881), hsa-mir-103a-3p (MIRT027036), hsa-mir-192-5p (MIRT026165)

    Block miRNA regulation of human, mouse, rat DNAJB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB4 (see all 19):
    hsa-miR-148b hsa-miR-15a hsa-miR-3692 hsa-miR-424 hsa-miR-3658 hsa-miR-195 hsa-miR-15b hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DNAJB4 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for DNAJB4
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DNAJB4

    Clone
    Products:             		 OriGene clones in human, mouse for DNAJB4 (see all 8)
    OriGene ORF clones in mouse, rat for DNAJB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJB4 (NM_007034)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB4
    Addgene plasmids for DNAJB4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DNAJB4
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJB4 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4


    Localization
    for DNAJB4 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJB4_HUMAN, Q9UDY4: Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and
    membrane-associated according to PubMed:16542645
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with DNAJB4           About GenesLikeMe


    Pathways & Interactions
    for DNAJB4 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB4: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJB4 (Q9UDY42, 3 ENSP000003597994) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48379 I2D: score=2 
    ENSG00000206286Q8N1B43I2D: score=4 
    ENSG00000224455Q8N1B43I2D: score=4 
    ENSG00000225590Q8N1B43I2D: score=4 
    ENSG00000228425Q8N1B43I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006986response to unfolded protein TAS9546042
    GO:0009408response to heat TAS9546042

    Find genes that share ontologies with DNAJB4           About GenesLikeMe



    Drugs & Compounds
    for DNAJB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJB4 (DNJB4)



    Transcripts
    for DNAJB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJB4 gene: 
    NM_007034.3  

    Unigene Cluster for DNAJB4:

    DnaJ (Hsp40) homolog, subfamily B, member 4
    Hs.13852  [show with all ESTs]
    Unigene Representative Sequence: AB209922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487931 ENST00000477671 ENST00000484662 ENST00000426517 ENST00000370763(uc010orn.2 uc001dij.3)
    ENST00000476396
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat DNAJB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB4 (see all 19):
    hsa-miR-148b hsa-miR-15a hsa-miR-3692 hsa-miR-424 hsa-miR-3658 hsa-miR-195 hsa-miR-15b hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DNAJB4 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for DNAJB4
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB4
    Clone
    Products:             		 OriGene clones in human, mouse for DNAJB4 (see all 8)
    OriGene ORF clones in mouse, rat for DNAJB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJB4 (NM_007034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB4
    Addgene plasmids for DNAJB4 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for DNAJB4
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB4
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJB4
      QuantiFast Probe-based Assays in human, mouse, rat DNAJB4

    Additional mRNA sequence: 

    AB209922.1 AK297985.1 AK313205.1 BC034721.1 U40992.2 

    13 DOTS entries:

    DT.212318  DT.95270445  DT.100816142  DT.92433994  DT.100805922  DT.100816143  DT.95270442  DT.95270451 
    DT.100816140  DT.121441438  DT.92420078  DT.95270444  DT.95270454 

    Selected AceView cDNA sequences (see all 201):

    BQ010464 BX283472 AI244754 BQ019079 BX435678 CR604945 AA576763 AI457779 
    BM980907 BQ000164 AU134887 CN484369 BQ877245 AW236690 BC034721 CB136941 
    BF726922 BQ945786 NM_007034 AU122165 AU280475 BP343368 BQ219280 AB073737 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for DNAJB4

    Expression
    for DNAJB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DNAJB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGATTGC
    DNAJB4 Expression
    About this image


    DNAJB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Thyroid (Endocrine System)
    DNAJB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    DNAJB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13852

    UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4
    Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta
    and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB4: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for DNAJB4
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB4
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJB4
    QuantiFast Probe-based Assays in human, mouse, rat DNAJB4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4

    Orthologs
    for DNAJB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB4 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dnajb41 , 5 DnaJ (Hsp40) homolog, subfamily B, member 41, 5 90.5(n)1
    94.07(a)1    		   3 (77.03 cM)5
    670351  NM_027287.41  NP_081563.21 
     1521785115 
    chicken
    (Gallus gallus)    		 Aves DNAJB41 DnaJ (Hsp40) homolog, subfamily B, member 4 79.72(n)
    83.98(a)    		   424550  XM_004936669.1  XP_004936726.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DNAJB46
    		 DnaJ (Hsp40) homolog, subfamily B, member 4
    		 84(a)
    		 1 ↔ 1
    		 GL343194.1(4850499-4862966)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia dnajb41 DnaJ (Hsp40) homolog, subfamily B, member 4 75.66(n)
    81.58(a)    		   100125006  NM_001102934.1  NP_001096404.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dnajb41 DnaJ (Hsp40) homolog, subfamily B, member 4 67.26(n)
    71.13(a)    		   445061  NM_001003455.1  NP_001003455.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta DnaJ-11 , 3 chaperone3
    DnaJ-like-11    		 55(a)
    (best of 4)3
    55.9(n)1
    59.63(a)1    		   64E53
    386431  NM_079212.41  NP_523936.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea dnj-131 dnj-13 55.38(n)
    56(a)    		   3564910  NM_064067.6  NP_496468.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G255301 AT5G25530 50.61(n)
    46.06(a)    		   832628  NM_122464.1  NP_197935.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_189096.12   -- 71.42(n)    NM_189096.1 


    ENSEMBL Gene Tree for DNAJB4 (if available)
    TreeFam Gene Tree for DNAJB4 (if available)

    Paralogs
    for DNAJB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJB4 gene
    DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    Selected SIMAP similar genes for DNAJB4 using alignment to 4 protein entries:     DNJB4_HUMAN (see all proteins) (see all similar genes):
    DNAJC1    DNAJB5    DNAJB1    DNAJC5B    DNAJB6    DNAJC17
    DNAJB2    DNAJC5G    DNAJC18    DNAJB12    DNAJB3    DNAJB13
    DNAJA4    DNAJB8    DNAJB9    DNAJC24    MST104    ZCSL3

    Find genes that share paralogs with DNAJB4           About GenesLikeMe



    Genomic Variants
    for DNAJB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJB4 (see all 281)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399048981,2
    		C--78468713(+) TTTTT-/TCTGCA 1 -- us2k10--------
    rs774694861,2
    		--78468748(+) GAACAA/GTTTCC 1 -- us2k10--------
    rs1904681681,2
    		--78468874(+) ATCCTC/TGCACT 1 -- us2k10--------
    rs1829153371,2
    		--78469022(+) AGCTGA/TCAAAC 1 -- us2k10--------
    rs1453419741,2
    		C--78469027(+) ACAAA-/CCTCTG 1 -- us2k10--------
    rs1428878651,2
    		--78469062(+) TGTTAC/TACATT 1 -- us2k10--------
    rs1150456121,2
    		F--78469118(+) AAATCG/ATAGCT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs111624041,2
    		C,F,H--78469197(+) GCGTTC/GTCATT 1 -- us2k16Minor allele frequency- G:0.05NS EA WA 538
    rs606707111,2
    		F--78469341(+) TCTCTA/CATAGA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1875503201,2
    		--78469603(+) TATTAC/TAGGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJB4 (78444859 - 78483648 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJB4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB4
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB4

    Disorders / Diseases
    for DNAJB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 611327    OMIM disorders: --

    1 disease for DNAJB4:    
    About MalaCards
    oculopharyngeal muscular dystrophy


    Find genes that share disorders with DNAJB4           About GenesLikeMe


    Export disorders for DNAJB4 gene to outside databases

    Publications
    for DNAJB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for DNAJB4 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with DNAJB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PubMed id 9546042)1, 2, 3, 9 Hoe K.L.... Yoo H.S. (Biochim. Biophys. Acta 1998)
    2. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PubMed id 16542645)1, 2 Ancevska-Taneva N....Simon E.J. (Brain Res. 2006)
    3. Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures. (PubMed id 15661747)1, 2 Borges J.C.... Ramos C.H.I. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    6. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. (PubMed id 16788156)1, 9 Tsai M.F....Yang P.C. (J. Natl. Cancer Inst. 2006)
    7. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. (PubMed id 15782117)1, 9 Wang C.C.... Yang P.C. (Oncogene 2005)
    8. Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen. (PubMed id 18837411)2, 9 Lin X....Wang X. (Sheng Wu Gong Cheng Xue Bao 2008)
    9. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PubMed id 24318877)1 Rauch J.N. and Gestwicki J.E. (J. Biol. Chem. 2014)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    External Searches for DNAJB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing DNAJB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11080 HGNC: 14886 AceView: DNAJB4andGIPC2 Ensembl:ENSG00000162616 euGenes: HUgn11080
    ECgene: DNAJB4 H-InvDB: DNAJB4

    Other Databases showing DNAJB4 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing DNAJB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DNAJB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNAJB4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DNAJB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for DNAJB4 gene:
    Search GeneIP for patents involving DNAJB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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