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Aliases for DNAJB4 Gene

Aliases for DNAJB4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B4 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 4 2 3
  • Heat Shock 40 KDa Protein 1 Homolog 3 4
  • Heat Shock Protein 40 Homolog 3 4
  • Human Liver DnaJ-Like Protein 3 4
  • HSP40 Homolog 3 4
  • DNAJW 3 4
  • HLJ1 3 4
  • DnaJ Homolog Subfamily B Member 4 3
  • DnaJ-Like Heat Shock Protein 40 3
  • DjB4 3

External Ids for DNAJB4 Gene

Previous GeneCards Identifiers for DNAJB4 Gene

  • GC01P078623
  • GC01P077417
  • GC01P077835
  • GC01P077893
  • GC01P078182
  • GC01P078444
  • GC01P076602

Summaries for DNAJB4 Gene

Entrez Gene Summary for DNAJB4 Gene

  • The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for DNAJB4 Gene

DNAJB4 (DnaJ Heat Shock Protein Family (Hsp40) Member B4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB1.

UniProtKB/Swiss-Prot for DNAJB4 Gene

  • Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Gene Wiki entry for DNAJB4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB4 Gene

Genomics for DNAJB4 Gene

Regulatory Elements for DNAJB4 Gene

Enhancers for DNAJB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G078002 2 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +27.8 27754 8.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ZFP64 ARID4B DNAJB4 RPL17P6 LOC653631 GIPC2 NEXN ENSG00000273338 LOC100131495
GH01G077680 1.1 ENCODE 6.5 -296.3 -296278 4.0 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 RPL17P6 GIPC2 AK5 DNAJB4 ZZZ3 RN7SL370P
GH01G077975 1.4 ENCODE dbSUPER 0.7 -0.9 -894 5.5 HDGF PKNOX1 FOXA2 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 RPL17P6 GIPC2 NEXN DNAJB4 NEXN-AS1
GH01G077949 0.8 ENCODE dbSUPER 0.3 -29.9 -29925 0.2 PAF1 CTCF POLR2A SMC3 EBF1 RAD21 DNAJB4 NEXN-AS1
GH01G077959 0.5 dbSUPER 0.4 -18.0 -17996 3.3 ZNF664 PAF1 POLR2A USP33 NEXN DNAJB4 NEXN-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB4 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008759 -275 3801 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for DNAJB4 Gene

Chromosome:
1
Start:
77,979,175 bp from pter
End:
78,018,721 bp from pter
Size:
39,547 bases
Orientation:
Plus strand

Genomic View for DNAJB4 Gene

Genes around DNAJB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB4 Gene

Proteins for DNAJB4 Gene

  • Protein details for DNAJB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDY4-DNJB4_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 4
    Protein Accession:
    Q9UDY4
    Secondary Accessions:
    • B2R824
    • Q13431

    Protein attributes for DNAJB4 Gene

    Size:
    337 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    • Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.

neXtProt entry for DNAJB4 Gene

Post-translational modifications for DNAJB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB4 Gene

No data available for DME Specific Peptides for DNAJB4 Gene

Domains & Families for DNAJB4 Gene

Gene Families for DNAJB4 Gene

Protein Domains for DNAJB4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB4: view

No data available for UniProtKB/Swiss-Prot for DNAJB4 Gene

Function for DNAJB4 Gene

Molecular function for DNAJB4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 24318877
GO:0005515 protein binding IPI 21255413
GO:0051082 unfolded protein binding TAS,IEA --
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB4: view
genes like me logo Genes that share phenotypes with DNAJB4: view

Animal Model Products

miRNA for DNAJB4 Gene

miRTarBase miRNAs that target DNAJB4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB4 Gene

Localization for DNAJB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB4 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB4 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 3
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 21231916
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DNAJB4: view

Pathways & Interactions for DNAJB4 Gene

SuperPathways for DNAJB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein TAS 9546042
GO:0009408 response to heat TAS 9546042
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with DNAJB4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB4 Gene

Transcripts for DNAJB4 Gene

Unigene Clusters for DNAJB4 Gene

DnaJ (Hsp40) homolog, subfamily B, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DNAJB4 Gene

GeneLoc Exon Structure for
DNAJB4
ECgene alternative splicing isoforms for
DNAJB4

Expression for DNAJB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJB4 Gene

This gene is overexpressed in Rectum (7.3), Urinary Bladder (6.7), and Prostate (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB4 Gene



Protein tissue co-expression partners for DNAJB4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJB4 Gene:

DNAJB4

SOURCE GeneReport for Unigene cluster for DNAJB4 Gene:

Hs.13852

mRNA Expression by UniProt/SwissProt for DNAJB4 Gene:

Q9UDY4-DNJB4_HUMAN
Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.

Evidence on tissue expression from TISSUES for DNAJB4 Gene

  • Liver(4.4)
  • Nervous system(3.9)
  • Heart(2.2)
  • Lung(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with DNAJB4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB4 Gene

Orthologs for DNAJB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB4 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia DNAJB4 34 35
  • 95.65 (n)
cow
(Bos Taurus)
Mammalia DNAJB4 34 35
  • 94.56 (n)
mouse
(Mus musculus)
Mammalia Dnajb4 34 16 35
  • 90.5 (n)
rat
(Rattus norvegicus)
Mammalia Dnajb4 34
  • 88.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB4 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJB4 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB4 34 35
  • 79.72 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJB4 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb4 34
  • 75.66 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajb4 34 35
  • 67.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta DnaJ-1 36 34 35
  • 55.9 (n)
CG5001 36 35
  • 50 (a)
CG2887 36 35
  • 44 (a)
CG12020 36
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007107 34
  • 54.82 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-13 34 35
  • 55.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25530 34
  • 50.61 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7032 34
rice
(Oryza sativa)
Liliopsida Os02g0128400 34
  • 47.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToMany
Species where no ortholog for DNAJB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB4 Gene

ENSEMBL:
Gene Tree for DNAJB4 (if available)
TreeFam:
Gene Tree for DNAJB4 (if available)

Paralogs for DNAJB4 Gene

genes like me logo Genes that share paralogs with DNAJB4: view

Variants for DNAJB4 Gene

Sequence variations from dbSNP and Humsavar for DNAJB4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs587778373 untested 77,978,949(-) CGGTG(A/G)TGGCG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000017085 -- 78,002,646(+) AAGCT(A/G)TAAGT intron-variant
rs1000066176 -- 78,011,725(+) GTGAT(A/C)CACCC intron-variant
rs1000078153 -- 78,000,965(+) ACCAG(A/C)CTGGG intron-variant
rs1000193945 -- 77,991,295(+) TCTCA(A/G)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB4 Gene

Variant ID Type Subtype PubMed ID
esv3586533 CNV loss 21293372

Variation tolerance for DNAJB4 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB4 Gene

Disorders for DNAJB4 Gene

Relevant External Links for DNAJB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB4

No disorders were found for DNAJB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB4 Gene

Publications for DNAJB4 Gene

  1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PMID: 9546042) Hoe K.L. … Yoo H.S. (Biochim. Biophys. Acta 1998) 2 3 4 22 64
  2. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch J.N. … Gestwicki J.E. (J. Biol. Chem. 2014) 3 4 64
  3. A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over- expression in neuro-progenitor cells. (PMID: 21255413) Lei J.X. … Liu Q.Y. (Mol. Neurodegener. 2011) 3 4 64
  4. Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen. (PMID: 18837411) Lin X. … Wang X. (Sheng Wu Gong Cheng Xue Bao 2008) 4 22 64
  5. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PMID: 16542645) Ancevska-Taneva N. … Simon E.J. (Brain Res. 2006) 3 4 64

Products for DNAJB4 Gene

Sources for DNAJB4 Gene

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