Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB4 Gene

protein-coding   GIFtS: 54
GCID: GC01P078444

DnaJ (Hsp40) Homolog, Subfamily B, Member 4
  8 related diseases
at
MalaCards
 

Aliases
for DNAJB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 41 2     HLJ12 3
Heat Shock 40 KDa Protein 1 Homolog2 3     HSP40 Homolog2 3
Heat Shock Protein 40 Homolog2 3     DjB42
Human Liver DnaJ-Like Protein2 3     DnaJ Homolog Subfamily B Member 42
DNAJW2 3     DnaJ-Like Heat Shock Protein 402

External Ids:    HGNC: 148861   Entrez Gene: 110802   Ensembl: ENSG000001626167   OMIM: 6113275   UniProtKB: Q9UDY43   

Export aliases for DNAJB4 gene to outside databases

Previous GC identifers: GC01P078623 GC01P077417 GC01P077835 GC01P077893 GC01P078182 GC01P076602


Summaries
for DNAJB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNAJB4 Gene:
DNAJB4 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ
family, see MIM 608375.(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAJB4 Gene: 
DNAJB4 (DnaJ (Hsp40) homolog, subfamily B, member 4) is a protein-coding gene. Diseases associated with DNAJB4 include oculopharyngeal muscular dystrophy, and non-small cell lung carcinoma. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJB5.

UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4
Function: Probable chaperone

Gene Wiki entry for DNAJB4 Gene


Genomic Views
for DNAJB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB4 gene promoter:
         Sox5   AML1a   AP-1   ATF-2   STAT3   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNAJB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P078444:  view genomic region     (about GC identifiers)

Start:
 78,444,859 bp from pter      End:
 78,483,648 bp from pter
Size:
 38,790 bases      Orientation:
 plus strand

Proteins
for DNAJB4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 4  
Size: 337 amino acids; 37807 Da
Subunit: Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1
Subcellular location: Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and
membrane-associated according to PubMed:16542645
Secondary accessions: B2R824 Q13431

Explore the universe of human proteins at neXtProt for DNAJB4: NX_Q9UDY4

Explore proteomics data for DNAJB4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UDY4

    • DNAJB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJB4 Protein Expression
    REFSEQ proteins: NP_008965.2  
    ENSEMBL proteins: 
     ENSP00000399494   ENSP00000359799  

    Human Recombinant Protein Products for DNAJB4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DNAJB4
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for DNAJB4 
    OriGene Custom Protein Services for DNAJB4
    GenScript Custom Purified and Recombinant Proteins Services for DNAJB4
    Novus Biologicals DNAJB4 Proteins
    Novus Biologicals DNAJB4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DNAJB4
    Cloud-Clone Corp. Proteins for DNAJB4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    DNAJB4 for ontologies           About GeneDecksing



    DNAJB4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DNAJB4
    GenScript Custom Superior Antibodies Services for DNAJB4
    Novus Biologicals DNAJB4 Antibodies
    Abcam antibodies for DNAJB4
    Cloud-Clone Corp. Antibodies for DNAJB4 
    Search ThermoFisher Antibodies for DNAJB4
    LSBio Antibodies in human, mouse, rat for DNAJB4 

    Assay Products for DNAJB4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNAJB4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNAJB4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNAJB4 
    Cloud-Clone Corp. CLIAs for DNAJB4

    Protein Domains /
    Families
    for DNAJB4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q9UDY4

    ProtoNet protein and cluster: Q9UDY4

    UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4
    Similarity: Contains 1 J domain


    DNAJB4 for domains           About GeneDecksing


    Function
    for DNAJB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJB4_HUMAN, Q9UDY4
    Function: Probable chaperone
    Induction: By heat shock

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0051082unfolded protein binding IEA--
         
    DNAJB4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DNAJB4:
     Increased gamma-H2AX phosphory  Increased homologous recombina  Lamellipodia cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNAJB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJB4 

    miRNA
    Products:            		miRTarBase miRNAs that target DNAJB4:
    hsa-mir-16 (MIRT001471)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAJB4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB4 (see all 19):
    hsa-miR-148b hsa-miR-15a hsa-miR-3692 hsa-miR-424 hsa-miR-3658 hsa-miR-195 hsa-miR-15b hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DNAJB4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DNAJB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DNAJB4
    Sirion Biotech Customized adenovirus for overexpression of DNAJB4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DNAJB4 (see all 8)
    OriGene ORF clones in mouse, rat for DNAJB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJB4 (NM_007034)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB4
    Sirion Biotech Customized lentivirus for stable overexpression of DNAJB4 
                         Customized lentivirus expression plasmids for stable overexpression of DNAJB4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DNAJB4
    Search LifeMap BioReagents cell lines for DNAJB4
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4


    Pathways & Interactions
    for DNAJB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/28 Interacting proteins for DNAJB4 (Q9UDY42, 3 ENSP000003597994) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48379 I2D: score=2 
    ENSG00000206286Q8N1B43I2D: score=4 
    ENSG00000224455Q8N1B43I2D: score=4 
    ENSG00000225590Q8N1B43I2D: score=4 
    ENSG00000228425Q8N1B43I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006986response to unfolded protein TAS9546042
    GO:0009408response to heat TAS9546042

    DNAJB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNAJB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB4 (DNJB4)

    Search CenterWatch for drugs/clinical trials and news about DNAJB4 / DNJB4

    Transcripts
    for DNAJB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNAJB4 gene: 
    NM_007034.3  

    Unigene Cluster for DNAJB4:

    DnaJ (Hsp40) homolog, subfamily B, member 4
    Hs.13852  [show with all ESTs]
    Unigene Representative Sequence: AB209922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487931 ENST00000477671 ENST00000484662 ENST00000426517 ENST00000370763(uc010orn.2 uc001dij.3)
    ENST00000476396
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAJB4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB4 (see all 19):
    hsa-miR-148b hsa-miR-15a hsa-miR-3692 hsa-miR-424 hsa-miR-3658 hsa-miR-195 hsa-miR-15b hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DNAJB4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DNAJB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB4
    Clone
    Products:             		 OriGene clones in human, mouse for DNAJB4 (see all 8)
    OriGene ORF clones in mouse, rat for DNAJB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJB4 (NM_007034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB4
    Sirion Biotech Customized lentivirus for stable overexpression of DNAJB4 
                         Customized lentivirus expression plasmids for stable overexpression of DNAJB4 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for DNAJB4
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB4

    Additional mRNA sequence: 

    AB209922.1 AK297985.1 AK313205.1 BC034721.1 U40992.2 

    13 DOTS entries:

    DT.212318  DT.95270445  DT.100816142  DT.92433994  DT.100805922  DT.100816143  DT.95270442  DT.95270451 
    DT.100816140  DT.121441438  DT.92420078  DT.95270444  DT.95270454 

    24/201 AceView cDNA sequences (see all 201):

    CN484369 AA450303 BP343368 BM476980 AI244754 AU120677 AI923132 AI457779 
    CK904783 AB073737 BF726922 AU122165 AI628742 AA081471 AA376190 BC034721 
    BX435678 BF970209 CR604945 BQ219280 BQ959703 AU134887 AA576763 AU280475 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for DNAJB4

    Expression
    for DNAJB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGATTGC
    DNAJB4 Expression
    About this image


    See DNAJB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB4

    SOURCE GeneReport for Unigene cluster: Hs.13852

    UniProtKB/Swiss-Prot: DNJB4_HUMAN, Q9UDY4
    Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta
    and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJB4: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for DNAJB4
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJB4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4

    Orthologs
    for DNAJB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB4 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dnajb41 , 5 DnaJ (Hsp40) homolog, subfamily B, member 41, 5 90.5(n)1
    94.07(a)1    		   3 (77.03 cM)5
    670351  NM_025926.31  NP_080202.11 
     1521785115 
    chicken
    (Gallus gallus)    		 Aves DNAJB41 DnaJ (Hsp40) homolog, subfamily B, member 4 79.72(n)
    83.98(a)    		   424550  XM_422386.3  XP_422386.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DNAJB46
    		 Uncharacterized protein
    		 84(a)
    		 1 ↔ 1
    		 GL343194.1(4850499-4862966)
    zebrafish
    (Danio rerio)    		 Actinopterygii dnajb41 DnaJ (Hsp40) homolog, subfamily B, member 4 67.26(n)
    71.13(a)    		   445061  NM_001003455.1  NP_001003455.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta DnaJ-11 , 3 chaperone3
    DnaJ-like-11    		 55(a)
    (best of 4)3
    55.49(n)1
    59.94(a)1    		   64E53
    386431  NM_079212.31  NP_523936.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea dnj-136
    		 Protein DNJ-13
    		 53(a)
    		 1 → many
    		 II(11545701-11547366)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SIS1(YNL007C)4 Type II HSP40 co-chaperone that interacts with the more   --   14(619565-618507) 855725  NP_014391.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G089101 DnaJ domain-containing protein 51.53(n)
    47.3(a)    		   820040  NM_111725.2  NP_187503.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_189096.12   -- 71.42(n)    NM_189096.1 


    ENSEMBL Gene Tree for DNAJB4 (if available)
    TreeFam Gene Tree for DNAJB4 (if available)

    Paralogs
    for DNAJB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB4 gene
    DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    18/23 SIMAP similar genes for DNAJB4 using alignment to 4 protein entries:     DNJB4_HUMAN (see all proteins) (see all similar genes):
    DNAJC1    DNAJB5    DNAJB1    DNAJC5B    DNAJB6    DNAJC17
    DNAJB2    DNAJC5G    DNAJC18    DNAJB12    DNAJB3    DNAJB13
    DNAJA4    DNAJB8    DNAJB9    DNAJC24    MST104    ZCSL3

    DNAJB4 for paralogs           About GeneDecksing



    Genomic Variants
    for DNAJB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/281 SNPs in DNAJB4 are shown (see all 281)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399048981,2
    		C--78468713(+) TTTTT-/TCTGCA 1 -- us2k10--------
    rs774694861,2
    		--78468748(+) GAACAA/GTTTCC 1 -- us2k10--------
    rs1904681681,2
    		--78468874(+) ATCCTC/TGCACT 1 -- us2k10--------
    rs1829153371,2
    		--78469022(+) AGCTGA/TCAAAC 1 -- us2k10--------
    rs1453419741,2
    		C--78469027(+) ACAAA-/CCTCTG 1 -- us2k10--------
    rs1428878651,2
    		--78469062(+) TGTTAC/TACATT 1 -- us2k10--------
    rs1150456121,2
    		F--78469118(+) AAATCG/ATAGCT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs111624041,2
    		C,F,H--78469197(+) GCGTTC/GTCATT 1 -- us2k16Minor allele frequency- G:0.05NS EA WA 538
    rs606707111,2
    		F--78469341(+) TCTCTA/CATAGA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1875503201,2
    		--78469603(+) TATTAC/TAGGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJB4 (78444859 - 78483648 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJB4: --
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB4
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB4

    Disorders / Diseases
    for DNAJB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 611327    OMIM disorders: --

    8 diseases for DNAJB4:    About MalaCards
    oculopharyngeal muscular dystrophy    non-small cell lung carcinoma    muscular dystrophy    hepatitis b
    tuberculosis    lung cancer    hepatitis    neuronitis


    DNAJB4 for disorders           About GeneDecksing


    Export disorders for DNAJB4 gene to outside databases

    Publications
    for DNAJB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB4 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with DNAJB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PubMed id 9546042)1, 2, 3, 9 Hoe K.L.... Yoo H.S. (1998)
    2. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PubMed id 16542645)1, 2 Ancevska-Taneva N....Simon E.J. (2006)
    3. Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures. (PubMed id 15661747)1, 2 Borges J.C.... Ramos C.H.I. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (2000)
    6. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. (PubMed id 16788156)1, 9 Tsai M.F....Yang P.C. (2006)
    7. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. (PubMed id 15782117)1, 9 Wang C.C.... Yang P.C. (2005)
    8. Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen. (PubMed id 18837411)2, 9 Lin X....Wang X. (2008)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for DNAJB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DNAJB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11080 HGNC: 14886 AceView: DNAJB4andGIPC2 Ensembl:ENSG00000162616 euGenes: HUgn11080
    ECgene: DNAJB4 H-InvDB: DNAJB4

    Other Databases showing DNAJB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNAJB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNAJB4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DNAJB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNAJB4 gene:
    Search GeneIP for patents involving DNAJB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DNAJB4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DNAJB4  
     OriGene qPCR primer pairs and template standards for DNAJB4   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for DNAJB4   OriGene clones in human, mouse for DNAJB4  
     OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB4   OriGene Purified Protein for DNAJB4  
     OriGene ORF clones in mouse, rat for DNAJB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DNAJB4   OriGene Custom Protein Services for DNAJB4  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJB4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB4
     GenScript Custom Purified and Recombinant Proteins Services for DNAJB4 GenScript cDNA clones with any tag delivered in your preferred vector for DNAJB4
     GenScript Custom Assay Services for DNAJB4 GenScript Custom Superior Antibodies Services for DNAJB4
     GenScript Custom overexpressing Cell Line Services for DNAJB4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DNAJB4 promoter
     Search Chromatin IP Primers for DNAJB4
     RT2 qPCR Primer Assay in human, mouse, rat DNAJB4
     GNC Network for DNAJB4
     SABiosciences PCR Arrays including human, mouse, rat DNAJB4
     Search Tocris compounds for DNAJB4 (DNJB4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DNAJB4 antibodies
     DNAJB4 proteins
     DNAJB4 lysates
     Antibodies for DNAJB4
     See all of Abcam's Antibodies, Kits and Proteins for DNAJB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DNAJB4




     Proteins for DNAJB4
     Antibodies for DNAJB4
     ELISAs for DNAJB4
     CLIAs for DNAJB4
     Search LifeMap BioReagents cell lines for DNAJB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4
     SwitchGear 3'UTR luciferase reporter plasmids for DNAJB4
     SwitchGear Promoter luciferase reporter plasmids for DNAJB4
     Search ThermoFisher Antibodies for DNAJB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJB4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNAJB4
    Customized:
     lentivirus for stable overexpression of DNAJB4
     lentivirus expression plasmids for stable overexpression of DNAJB4
     adenovirus for overexpression of DNAJB4
     LSBio Antibodies in human, mouse, rat for DNAJB4
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DNAJB4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4