Aliases for DNAJB4 Gene
Aliases for DNAJB4 Gene
External Ids for DNAJB4 Gene
- HGNC: 14886
- Entrez Gene: 11080
- Ensembl: ENSG00000162616
- OMIM: 611327
- UniProtKB: Q9UDY4
Previous GeneCards Identifiers for DNAJB4 Gene
- GC01P078623
- GC01P077417
- GC01P077835
- GC01P077893
- GC01P078182
- GC01P078444
- GC01P076602
Summaries for DNAJB4 Gene
-
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for DNAJB4 Gene
DNAJB4 (DnaJ Heat Shock Protein Family (Hsp40) Member B4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB1.
UniProtKB/Swiss-Prot for DNAJB4 Gene
-
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Additional gene information for DNAJB4 Gene
- Monarch Initiative
- Search for DNAJB4 at DataMed
- Search for DNAJB4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB4 Gene
Genomics for DNAJB4 Gene
GeneHancer (GH) Regulatory Elements for DNAJB4 Gene
Promoters and enhancers for DNAJB4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DNAJB4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DNAJB4 Gene
Genomic Locations for DNAJB4 Gene
- chr1:77,979,175-78,018,721
- (GRCh38/hg38)
- Size:
- 39,547 bases
- Orientation:
- Plus strand
- chr1:78,444,859-78,483,648
- (GRCh37/hg19)
Genomic View for DNAJB4 Gene
Genes around DNAJB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by Ensembl
- 1p31.1 by Entrez Gene
- 1p31.1 by HGNC
DNAJB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DNAJB4 Gene
Proteins for DNAJB4 Gene
-
Protein details for DNAJB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UDY4-DNJB4_HUMAN
- Recommended name:
- DnaJ homolog subfamily B member 4
- Protein Accession:
- Q9UDY4
- B2R824
- Q13431
Protein attributes for DNAJB4 Gene
- Size:
- 337 amino acids
- Molecular mass:
- 37807 Da
- Quaternary structure:
-
- Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.
Protein Expression for DNAJB4 Gene
Post-translational modifications for DNAJB4 Gene
No Post-translational modifications
Other Protein References for DNAJB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DNAJB4
- Invitrogen Antibodies for DNAJB4
- Search GeneTex for Antibodies for DNAJB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for DNAJB4
Protein Products
-
OriGene Purified Proteins for DNAJB4
- Search Origene for MassSpec and Protein Over-expression Lysates for DNAJB4
- Origene Custom Protein Services for DNAJB4
- ProSpec Recombinant Proteins for DNAJB4
- antibodies-online: Search results for 8 available DNAJB4 Proteins ranked by validation data
- Compare Top DNAJB4 Proteins
-
Quality Products:
- Search GeneTex for Proteins for DNAJB4
-
Abcam proteins for DNAJB4
Assay Products
No data available for DME Specific Peptides for DNAJB4 Gene
Domains & Families for DNAJB4 Gene
Gene Families for DNAJB4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DNAJB4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DNAJB4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DNAJB4 Gene
Function for DNAJB4 Gene
Molecular function for DNAJB4 Gene
- UniProtKB/Swiss-Prot Function:
- Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
- UniProtKB/Swiss-Prot Induction:
- By heat shock.
Phenotypes From GWAS Catalog for DNAJB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001671 | ATPase activator activity | IDA | 24318877 |
| GO:0005515 | protein binding | IPI | 21255413 |
| GO:0051082 | unfolded protein binding | IEA,TAS | -- |
| GO:0051087 | chaperone binding | IPI | 21231916 |
Phenotypes for DNAJB4 Gene
- GenomeRNAi human phenotypes for DNAJB4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Lamellipodia cells
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DNAJB4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DNAJB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJB4 gene
- Search ViGene Biosciences for DNAJB4
CRISPR Products
-
OriGene CRISPR knockouts for DNAJB4
- genomics-online: gRNA clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
- Applied Biological Materials CRISPR for DNAJB4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DNAJB4
- GenScript: Design CRISPR guide RNA sequences for DNAJB4
miRNA for DNAJB4 Gene
- miRTarBase miRNAs that target DNAJB4
-
- hsa-mir-16-5p (MIRT001471)
- hsa-mir-148b-3p (MIRT019300)
- hsa-mir-142-3p (MIRT021629)
- hsa-mir-215-5p (MIRT024618)
- hsa-mir-148a-3p (MIRT026002)
- hsa-mir-192-5p (MIRT026165)
- hsa-mir-103a-3p (MIRT027036)
- hsa-mir-30a-5p (MIRT028464)
- hsa-mir-26b-5p (MIRT028881)
- hsa-mir-548n (MIRT079618)
- hsa-mir-1284 (MIRT079621)
- hsa-mir-3607-5p (MIRT079623)
- hsa-mir-4666a-5p (MIRT079631)
- hsa-mir-1206 (MIRT198429)
- hsa-mir-5089-5p (MIRT290012)
- hsa-mir-183-3p (MIRT478064)
- hsa-mir-5696 (MIRT478065)
- hsa-mir-877-5p (MIRT478066)
- hsa-mir-4524a-3p (MIRT478067)
- hsa-mir-15b-3p (MIRT478068)
- hsa-mir-4729 (MIRT478069)
- hsa-mir-3976 (MIRT478070)
- hsa-mir-6859-5p (MIRT478071)
- hsa-mir-3916 (MIRT478072)
- hsa-mir-3125 (MIRT478073)
- hsa-mir-4641 (MIRT478074)
- hsa-mir-7853-5p (MIRT478075)
- hsa-mir-105-5p (MIRT478076)
- hsa-mir-577 (MIRT478077)
- hsa-mir-7-2-3p (MIRT478078)
- hsa-mir-7-1-3p (MIRT478079)
- hsa-mir-365a-3p (MIRT478080)
- hsa-mir-365b-3p (MIRT478081)
- hsa-mir-3674 (MIRT538047)
- hsa-mir-135b-3p (MIRT538048)
- hsa-mir-7156-3p (MIRT538049)
- hsa-mir-6516-3p (MIRT538050)
- hsa-mir-1255b-5p (MIRT538051)
- hsa-mir-1255a (MIRT538052)
- hsa-mir-3121-5p (MIRT538053)
- hsa-mir-7845-5p (MIRT538054)
- hsa-mir-4802-3p (MIRT538055)
- hsa-mir-586 (MIRT558348)
- hsa-mir-7151-3p (MIRT688453)
- hsa-mir-5095 (MIRT688454)
- hsa-mir-5589-5p (MIRT688455)
- hsa-mir-4731-5p (MIRT688456)
- hsa-mir-6778-3p (MIRT688457)
- hsa-mir-6506-5p (MIRT688458)
- hsa-mir-619-5p (MIRT688459)
- hsa-mir-7107-5p (MIRT688460)
- hsa-mir-1234-3p (MIRT688461)
- hsa-mir-186-3p (MIRT688462)
- hsa-mir-1273g-3p (MIRT688463)
- hsa-mir-520h (MIRT688464)
- hsa-mir-520g-3p (MIRT688465)
- hsa-mir-6504-3p (MIRT688466)
- hsa-mir-512-3p (MIRT688467)
- hsa-mir-4438 (MIRT688468)
- hsa-mir-93-5p (MIRT688469)
- hsa-mir-526b-3p (MIRT688470)
- hsa-mir-519d-3p (MIRT688471)
- hsa-mir-20b-5p (MIRT688472)
- hsa-mir-20a-5p (MIRT688473)
- hsa-mir-17-5p (MIRT688474)
- hsa-mir-106b-5p (MIRT688475)
- hsa-mir-106a-5p (MIRT688476)
- hsa-mir-520a-3p (MIRT688477)
- hsa-mir-372-3p (MIRT688478)
- hsa-mir-302e (MIRT688479)
- hsa-mir-302c-3p (MIRT688480)
- hsa-mir-373-3p (MIRT688481)
- hsa-mir-302b-3p (MIRT688482)
- hsa-mir-302a-3p (MIRT688483)
- hsa-mir-520b (MIRT688484)
- hsa-mir-520c-3p (MIRT688485)
- hsa-mir-520d-3p (MIRT688486)
- hsa-mir-520e (MIRT688487)
- hsa-mir-302d-3p (MIRT688488)
- hsa-mir-6878-3p (MIRT704175)
- hsa-mir-6744-3p (MIRT704176)
- hsa-mir-4757-5p (MIRT704177)
- hsa-mir-4312 (MIRT704178)
- hsa-mir-150-5p (MIRT704179)
- hsa-mir-212-5p (MIRT704180)
- hsa-mir-6747-3p (MIRT704181)
- hsa-mir-3973 (MIRT704182)
- hsa-mir-1289 (MIRT762278)
- hsa-mir-224-3p (MIRT763959)
- hsa-mir-31-3p (MIRT764978)
- hsa-mir-3198 (MIRT765500)
- hsa-mir-4294 (MIRT768448)
- hsa-mir-4309 (MIRT768539)
- hsa-mir-431-5p (MIRT768577)
- hsa-mir-4423-5p (MIRT768857)
- hsa-mir-4694-3p (MIRT771132)
- hsa-mir-4781-3p (MIRT772259)
- hsa-mir-522-3p (MIRT773886)
- hsa-mir-6501-5p (MIRT776522)
- hsa-mir-6514-5p (MIRT777032)
- hsa-mir-744-3p (MIRT781712)
- hsa-mir-924 (MIRT782653)
miRNA Products
- Search ViGene Biosciences for DNAJB4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DNAJB4
- Browse OriGene Inhibitory RNA Products For DNAJB4
- genomics-online: shRNA clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJB4 gene
Clone Products
- Sino Biological Human cDNA Clone for DNAJB4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DNAJB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DNAJB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DNAJB4
- Applied Biological Materials Clones for DNAJB4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DNAJB4
-
ViGene Biosciences adenoviral particle packaged cDNA for DNAJB4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DNAJB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJB4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB4 Gene
Localization for DNAJB4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DNAJB4 Gene
- Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | 21231916 |
| GO:0005886 | plasma membrane | IEA,IDA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for DNAJB4 Gene
No Data Available
Interacting Proteins for DNAJB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | IEA | -- |
| GO:0006986 | response to unfolded protein | TAS | 9546042 |
| GO:0009408 | response to heat | TAS | 9546042 |
| GO:0032781 | positive regulation of ATPase activity | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for DNAJB4 Gene
Transcripts for DNAJB4 Gene
mRNA/cDNA for DNAJB4 Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (201) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DNAJB4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DNAJB4
- genomics-online: gRNA clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
- Applied Biological Materials CRISPR for DNAJB4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DNAJB4
- GenScript: Design CRISPR guide RNA sequences for DNAJB4
miRNA Products
- Search ViGene Biosciences for DNAJB4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DNAJB4
- Browse OriGene Inhibitory RNA Products For DNAJB4
- genomics-online: shRNA clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJB4 gene
Clone Products
- Sino Biological Human cDNA Clone for DNAJB4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DNAJB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DNAJB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DNAJB4
- Applied Biological Materials Clones for DNAJB4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | - |
Expression for DNAJB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Adrenal Gland (Endocrine System)
This gene is overexpressed in Rectum (7.3), Urinary Bladder (6.7), and Prostate (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DNAJB4 Gene:
DNAJB4SOURCE GeneReport for Unigene cluster for DNAJB4 Gene:
Hs.13852mRNA Expression by UniProt/SwissProt for DNAJB4 Gene:
Q9UDY4-DNJB4_HUMAN
Tissue specificity:
Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
Evidence on tissue expression from TISSUES for DNAJB4 Gene
- Liver(4.4)
- Nervous system(3.9)
- Heart(2.2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DNAJB4
-
OriGene qPCR primer pairs for DNAJB4
- genomics-online: primer clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB4 Gene
Orthologs for DNAJB4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DNAJB4 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DNAJB4 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | DNAJB4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Dnajb4 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dnajb4 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DNAJB4 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | DNAJB4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DNAJB4 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DNAJB4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dnajb4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dnajb4 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | DnaJ-1 35 33 34 |
|
||
| CG5001 35 34 |
|
||||
| CG2887 35 34 |
|
||||
| CG12020 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007107 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | dnj-13 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SIS1 36 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G25530 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7032 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0128400 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for DNAJB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DNAJB4 Gene
(23) SIMAP similar genes for DNAJB4 Gene using alignment to 4 proteins:
Variants for DNAJB4 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs587778373 | not-provided, not specified | 77,978,949(+) | C/T | upstream_transcript_variant | |
| rs1000017085 | -- | 78,002,646(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000066176 | -- | 78,011,725(+) | C/A | intron_variant | |
| rs1000078153 | -- | 78,000,965(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000193945 | -- | 77,991,295(+) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3586533 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DNAJB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DNAJB4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB4 Gene
Disorders for DNAJB4 Gene
Additional Disease Information for DNAJB4
No disorders were found for DNAJB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB4 Gene
Publications for DNAJB4 Gene
- Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PMID: 9546042) Hoe KL … Yoo HS (Biochimica et biophysica acta 1998) 2 3 4 22 58
- Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4 58
- A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells. (PMID: 21255413) Lei JX … Liu QY (Molecular neurodegeneration 2011) 3 4 58
- [Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen]. (PMID: 18837411) Lin X … Wang X (Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2008) 4 22 58
- A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PMID: 16542645) Ancevska-Taneva N … Simon EJ (Brain research 2006) 3 4 58
Products for DNAJB4 Gene
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DNAJB4
- Search Origene for MassSpec and Protein Over-expression Lysates for DNAJB4
- Origene Custom Protein Services for DNAJB4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DNAJB4
- Browse OriGene Inhibitory RNA Products For DNAJB4
- OriGene qPCR primer pairs and template standards for DNAJB4
- OriGene qPCR primer pairs for DNAJB4
- OriGene CRISPR knockouts for DNAJB4
- OriGene ORF clones in human for DNAJB4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DNAJB4
- GenScript: Next-day shipping of latest version cDNA ORF clones for DNAJB4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DNAJB4
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- GenScript Custom overexpressing Cell Line Services for DNAJB4
- GenScript: Design CRISPR guide RNA sequences for DNAJB4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DNAJB4
- Sino Biological Human cDNA Clone for DNAJB4
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Antibodies
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- Browse Sino Biological ELISA Kits
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DNAJB4
- Novus Biologicals lysates and proteins for DNAJB4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam proteins for DNAJB4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for DNAJB4
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for DNAJB4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for DNAJB4
- VectorBuilder custom plasmid, inducible vectors for DNAJB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DNAJB4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DNAJB4
- antibodies-online: Search results for 58 available DNAJB4 Antibodies ranked by validation data
- Compare Top DNAJB4 Antibodies
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- antibodies-online: Search results for available DNAJB4 related products ranked by validation data
- antibodies-online: Search results for 8 available DNAJB4 Proteins ranked by validation data
- Compare Top DNAJB4 Proteins
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- Search GeneTex for Antibodies for DNAJB4
- Search GeneTex for Proteins for DNAJB4
- ViGene Biosciences adenoviral particle packaged cDNA for DNAJB4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DNAJB4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DNAJB4 gene
- Search ViGene Biosciences for DNAJB4
- Santa Cruz Biotechnology (SCBT) Antibodies for DNAJB4
- Search Santa Cruz Biotechnology (SCBT) for DNAJB4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DNAJB4
- Horizon Cell Lines for DNAJB4
- genomics-online: cdna clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
- orf clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
- genomics-online: gRNA clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
- genomics-online: primer clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
- genomics-online: shRNA clones - Search results for 118 available DNAJB4 gene related products
- Overview of 118 available DNAJB4 gene related products
Sources for DNAJB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew