DNAJB4 Gene

Aliases
for DNAJB4 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01P078623 GC01P077417 GC01P077835 GC01P077893 GC01P078182 GC01P076602

Summaries
for DNAJB4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for DNAJB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_032977.10  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: DNAJB4 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB4

DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P078444:  view genomic region     (about GC identifiers)

Proteins
for DNAJB4 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for DNAJB4: NX_Q9UDY4

Explore proteomics data for DNAJB4 at MOPED

Post-translational modifications: 

DNAJB4 Human Recombinant Protein Products:

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	antibodies-online peptides for DNAJB4

DNAJB4 Antibody Products:

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Domains /
Families
for DNAJB4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UDY4

Find genes that share domains with DNAJB4           About GenesLikeMe

Function
for DNAJB4 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for DNAJB4

miRNA Products:		miRTarBase miRNAs that target DNAJB4: hsa-mir-148a-3p (MIRT026002), hsa-mir-142-3p (MIRT021629), hsa-mir-148b-3p (MIRT019300), hsa-mir-215-5p (MIRT024618), hsa-mir-30a-5p (MIRT028464), hsa-mir-16-5p (MIRT001471), hsa-mir-26b-5p (MIRT028881), hsa-mir-103a-3p (MIRT027036), hsa-mir-192-5p (MIRT026165)
		Block miRNA regulation of human, mouse, rat DNAJB4 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DNAJB4 (see all 19):
		hsa-miR-148b hsa-miR-15a hsa-miR-3692 hsa-miR-424 hsa-miR-3658 hsa-miR-195 hsa-miR-15b hsa-miR-515-3p
		SwitchGear 3'UTR luciferase reporter plasmid: DNAJB4 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DNAJB4
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DNAJB4

Clone Products:		OriGene clones in human, mouse for DNAJB4 (see all 8) OriGene ORF clones in mouse, rat for DNAJB4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB4
		Addgene plasmids for DNAJB4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNAJB4
		Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJB4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4

Localization
for DNAJB4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	4
nucleus	4
mitochondrion	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for DNAJB4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for DNAJB4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for DNAJB4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for DNAJB4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DNAJB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TATAGATTGC

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Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Testis (Reproductive System)
Leydig Cells Testis Interstitium
Liver (Hepatobiliary System)
Hepatocytes Liver Lobule
Thyroid (Endocrine System)

Primer Products:		OriGene qPCR primer pairs and template standards for DNAJB4 OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB4
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		QuantiFast Probe-based Assays in human, mouse, rat DNAJB4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB4

Orthologs
for DNAJB4 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for DNAJB4 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for DNAJB4 gene

DNAJB5²  DNAJB13²  DNAJB2²  DNAJB9²  DNAJB6²  DNAJB1²  DNAJB7²  DNAJC5B²  

DNAJC5²  DNAJC5G²  DNAJB8²  

Selected SIMAP similar genes for DNAJB4 using alignment to 4 protein entries:     DNJB4_HUMAN (see all proteins) (see all similar genes):

DNAJC1    DNAJB5    DNAJB1    DNAJC5B    DNAJB6    DNAJC17

DNAJB2    DNAJC5G    DNAJC18    DNAJB12    DNAJB3    DNAJB13

DNAJA4    DNAJB8    DNAJB9    DNAJC24    MST104    ZCSL3

Find genes that share paralogs with DNAJB4           About GenesLikeMe

Genomic Variants
for DNAJB4 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DNAJB4 (see all 281)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1399048981,2	C	--	78468713(+)	TTTTT-/TCTGCA	1	--	us2k1		0	--	--	--	--
rs774694861,2		--	78468748(+)	GAACAA/GTTTCC	1	--	us2k1		0	--	--	--	--
rs1904681681,2		--	78468874(+)	ATCCTC/TGCACT	1	--	us2k1		0	--	--	--	--
rs1829153371,2		--	78469022(+)	AGCTGA/TCAAAC	1	--	us2k1		0	--	--	--	--
rs1453419741,2	C	--	78469027(+)	ACAAA-/CCTCTG	1	--	us2k1		0	--	--	--	--
rs1428878651,2		--	78469062(+)	TGTTAC/TACATT	1	--	us2k1		0	--	--	--	--
rs1150456121,2	F	--	78469118(+)	AAATCG/ATAGCT	1	--	us2k1		1		WA	118
rs111624041,2	C,F,H	--	78469197(+)	GCGTTC/GTCATT	1	--	us2k1		6		NS EA WA	538
rs606707111,2	F	--	78469341(+)	TCTCTA/CATAGA	1	--	us2k1		1		WA	118
rs1875503201,2		--	78469603(+)	TATTAC/TAGGGA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNAJB4 (78444859 - 78483648 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DNAJB4: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DNAJB4

DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB4

Disorders / Diseases
for DNAJB4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for DNAJB4 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DNAJB4 gene, integrated from 10 sources (see all 33): (articles sorted by number of sources associating them with DNAJB4)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PubMed id 9546042)^{1, 2, 3, 9} Hoe K.L.... Yoo H.S. (Biochim. Biophys. Acta 1998)
2. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PubMed id 16542645)^{1, 2} Ancevska-Taneva N....Simon E.J. (Brain Res. 2006)
3. Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures. (PubMed id 15661747)^{1, 2} Borges J.C.... Ramos C.H.I. (J. Biol. Chem. 2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)^{1, 3} Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
6. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. (PubMed id 16788156)^{1, 9} Tsai M.F....Yang P.C. (J. Natl. Cancer Inst. 2006)
7. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. (PubMed id 15782117)^{1, 9} Wang C.C.... Yang P.C. (Oncogene 2005)
8. Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen. (PubMed id 18837411)^{2, 9} Lin X....Wang X. (Sheng Wu Gong Cheng Xue Bao 2008)
9. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PubMed id 24318877)¹ Rauch J.N. and Gestwicki J.E. (J. Biol. Chem. 2014)
10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)¹ Chen Y....Ge F. (amp 2013)

External Searches for DNAJB4 gene

Genome Databases showing DNAJB4 gene

Other Databases showing DNAJB4 gene

Specialized Databases showing DNAJB4 gene

Products
for DNAJB4 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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