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Aliases for DNAJB3 Gene

Aliases for DNAJB3 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 3 2 3
  • HCG3 3 4
  • DnaJ Homolog Subfamily B Member 3 3

External Ids for DNAJB3 Gene

Previous GeneCards Identifiers for DNAJB3 Gene

  • GC02U901524
  • GC02M234318
  • GC02M234651
  • GC02M226451

Summaries for DNAJB3 Gene

GeneCards Summary for DNAJB3 Gene

DNAJB3 (DnaJ (Hsp40) Homolog, Subfamily B, Member 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DNAJB3 Gene

  • May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB3 Gene

Genomics for DNAJB3 Gene

Regulatory Elements for DNAJB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJB3 Gene

Start:
233,742,750 bp from pter
End:
233,744,015 bp from pter
Size:
1,266 bases
Orientation:
Minus strand

Genomic View for DNAJB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB3 Gene

Proteins for DNAJB3 Gene

  • Protein details for DNAJB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWF6-DNJB3_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 3
    Protein Accession:
    Q8WWF6
    Secondary Accessions:

    Protein attributes for DNAJB3 Gene

    Size:
    145 amino acids
    Molecular mass:
    16559 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJB3 Gene

neXtProt entry for DNAJB3 Gene

Proteomics data for DNAJB3 Gene at MOPED

Post-translational modifications for DNAJB3 Gene

  • Ubiquitination at Lys29
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJB3 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB3 Gene

Domains for DNAJB3 Gene

Gene Families for DNAJB3 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJB3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWF6

UniProtKB/Swiss-Prot:

DNJB3_HUMAN :
  • Q8WWF6
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB3: view

Function for DNAJB3 Gene

Molecular function for DNAJB3 Gene

UniProtKB/Swiss-Prot Function: May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAJB3 Gene

Localization for DNAJB3 Gene

Gene Ontology (GO) - Cellular Components for DNAJB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DNAJB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for DNAJB3 Gene

Pathways for DNAJB3 Gene

SuperPathways for DNAJB3 Gene

No Data Available

Interacting Proteins for DNAJB3 Gene

Selected Interacting proteins: Q8WWF6-DNJB3_HUMAN for DNAJB3 Gene via MINT I2D

Symbol External ID(s) Details
EWSR1
--
--
  • Q96MX4 21
--

Gene Ontology (GO) - Biological Process for DNAJB3 Gene

None

No data available for Pathways by source for DNAJB3 Gene

Transcripts for DNAJB3 Gene

mRNA/cDNA for DNAJB3 Gene

(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB3 Gene

DnaJ (Hsp40) homolog, subfamily B, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB3 Gene

No ASD Table

Relevant External Links for DNAJB3 Gene

GeneLoc Exon Structure for
DNAJB3
ECgene alternative splicing isoforms for
DNAJB3

Expression for DNAJB3 Gene

mRNA expression in normal human tissues for DNAJB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB3 Gene

This gene is overexpressed in Testis (47.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DNAJB3 Gene

SOURCE GeneReport for Unigene cluster for DNAJB3 Gene Hs.725533

mRNA Expression by UniProt/SwissProt for DNAJB3 Gene

Q8WWF6-DNJB3_HUMAN
Tissue specificity: Expressed in sperm (at protein level).
genes like me logo Genes that share expressions with DNAJB3: view

In Situ Assay Products

Orthologs for DNAJB3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DNAJB3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Dnajb3 16
Species with no ortholog for DNAJB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DNAJB3 Gene

ENSEMBL:
Gene Tree for DNAJB3 (if available)
TreeFam:
Gene Tree for DNAJB3 (if available)

Paralogs for DNAJB3 Gene

Selected SIMAP similar genes for DNAJB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJB3: view

No data available for Paralogs for DNAJB3 Gene

Variants for DNAJB3 Gene

Sequence variations from dbSNP and Humsavar for DNAJB3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_061142 -
VAR_061143 -

Structural Variations from Database of Genomic Variants (DGV) for DNAJB3 Gene

Variant ID Type Subtype PubMed ID
nsv3215 CNV Loss 18451855
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061

Relevant External Links for DNAJB3 Gene

HapMap Linkage Disequilibrium report
DNAJB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB3 Gene

Disorders for DNAJB3 Gene

No disorders were found for DNAJB3 Gene.

No data available for UniProtKB/Swiss-Prot for DNAJB3 Gene

Publications for DNAJB3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Structure of msj-1 gene: a comparative analysis. (PMID: 15891074) Meccariello R. … Fasano S. (Ann. N. Y. Acad. Sci. 2005) 3
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for DNAJB3 Gene

  • antibodies-online proteins for DNAJB3
  • antibodies-online antibodies for DNAJB3
  • antibodies-online kits for DNAJB3

Sources for DNAJB3 Gene

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