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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB3 Gene

pseudogene   GIFtS: 32
GCID: GC02M234651

DnaJ (Hsp40) Homolog, Subfamily B, Member 3

  Search for DNAJB3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 31 2
HCG32 3
DnaJ Homolog Subfamily B Member 32

External Ids:    HGNC: 323971   Entrez Gene: 4140612   Ensembl: ENSG000002278027   UniProtKB: Q8WWF63   

Export aliases for DNAJB3 gene to outside databases

Previous GC identifers: GC02U901524 GC02M234318 GC02M226451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DNAJB3 Gene: 
DNAJB3 (DnaJ (Hsp40) homolog, subfamily B, member 3) is a pseudogene. GO annotations related to this gene include unfolded protein binding and heat shock protein binding.

UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6
Function: May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins
(Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB3 gene promoter:
         AML1a   p53   p300   NRSF form 2   HNF-4alpha1   Arnt   PPAR-alpha   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

DNAJB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M234651:  view genomic region     (about GC identifiers)

Start:
234,651,396 bp from pter      End:
234,652,661 bp from pter
Size:
1,266 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 3  
Size: 145 amino acids; 16559 Da
Caution: Due to a premature stop codon, the human protein is truncated and lacks the DNAJB3 canonical C-terminal
domain. However, expression studies suggest the existence of the mRNA and protein in human
1 PDB 3D structure from and Proteopedia for DNAJB3:
2EJ7 (3D)    

Explore the universe of human proteins at neXtProt for DNAJB3: NX_Q8WWF6

Explore proteomics data for DNAJB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWF6

  • DNAJB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJB3 Protein Expression
    REFSEQ proteins: NP_001001394.1  
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    2 InterPro protein domains:
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q8WWF6

    ProtoNet protein and cluster: Q8WWF6

    UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6
    Similarity: Contains 1 J domain


    DNAJB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJB3_HUMAN, Q8WWF6
    Function: May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins
    (Potential)

    Phenotypes:
         1 MGI phenotypic allele for Dnajb3 (no phenotypes)


    DNAJB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnajb3tm1(KOMP)Vlcg for DNAJB3

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB3

    4 Interacting proteins for DNAJB3 (Q8WWF62, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443I2D: score=2 
    --Q9BWA23, 2MINT-66355 I2D: score=1 
    --Q9BWA23, 2MINT-66355 I2D: score=1 
    --Q96MX43I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB3 (DNJB3)

    Search CenterWatch for drugs/clinical trials and news about DNAJB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB3 gene: 
    NM_001001394.3  

    Unigene Cluster for DNAJB3:

    DnaJ (Hsp40) homolog, subfamily B, member 3
    Hs.725533  [show with all ESTs]
    Unigene Representative Sequence: AY083665
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449667(uc002vuz.3) ENST00000446806
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    SwitchGear 3'UTR luciferase reporter plasmidDNAJB3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AY083665.1 BC017590.2 BC024013.2 

    2 DOTS entries:

    DT.97782222  DT.97784082 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB3 expression in normal human tissues (normalized intensities)      DNAJB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTATTAT
    DNAJB3 Expression
    About this image


    DNAJB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See DNAJB3 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.725533

    UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6
    Tissue specificity: Expressed in sperm (at protein level)

        SABiosciences Custom PCR Arrays for DNAJB3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for DNAJB3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb35 DnaJ (Hsp40) homolog, subfamily B, member 3   --   1 (44.55 cM) 88204732 


    ENSEMBL Gene Tree for DNAJB3 (if available)
    TreeFam Gene Tree for DNAJB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB3 gene
    18 SIMAP similar genes for DNAJB3 using alignment to 1 protein entry:     DNJB3_HUMAN:
    DNAJB6    DNAJB8    DNAJB7    DNAJB2    DNAJC5B    DNAJC16
    DNAJB4    DNAJB5    DNAJC17    DNAJC21    DNAJB1    DNAJC5G
    DNAJC10    DNAJB12    DNAJC11    DNAJC18    DNAJA4    DNAJC7

    DNAJB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in DNAJB3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0611434
    ----see VAR_0611432 D E mis40--------
    VAR_0611424
    ----see VAR_0611422 D E mis40--------

    HapMap Linkage Disequilibrium report for DNAJB3 (234651396 - 234652661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DNAJB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv769e199CNV Deletion23128226
    esv2422005CNV Deletion20811451
    nsv498958CNV Loss21111241
    nsv519815CNV Loss19592680
    nsv3215CNV Loss18451855
    esv25622CNV Loss19812545
    nsv433211CNV Loss18776910
    nsv514125CNV Loss21397061

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DNAJB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    6. Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction. (PubMed id 18184612)2 Meccariello R....Fasano S. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. Structure of msj-1 gene: a comparative analysis. (PubMed id 15891074)1 Meccariello R....Fasano S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 414061 HGNC: 32397 Ensembl:ENSG00000227802 euGenes: HUgn414061 ECgene: DNAJB3
    H-InvDB: DNAJB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJB3 gene:
    Search GeneIP for patents involving DNAJB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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