DNAJB3 Gene
pseudogene GIFtS: 33
GCID: GC02M234651
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DnaJ (Hsp40) homolog, subfamily B, member 3
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Aliases
for DNAJB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily B, Member 31 2 | | HCG31 2 3 | | DnaJ Homolog Subfamily B Member 32 |
Export aliases for DNAJB3 gene to outside databasesPrevious GC identifers: GC02U901524 GC02M234318 GC02M226451 |
Summaries
for DNAJB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6Function: May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins (Potential)
|
Genomic Views
for DNAJB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005120.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJB3 gene promoter:
AML1a p53 p300 NRSF form 2 HNF-4alpha1 Arnt PPAR-alpha HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37DNAJB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M234651: view genomic region
(about GC identifiers)
Start:
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234,651,396 bp from pter |
End:
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234,652,661 bp from pter |
Size:
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1,266 bases |
Orientation:
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minus strand |
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Proteins
for DNAJB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6 (See
protein sequence)Recommended Name: DnaJ homolog subfamily B member 3 Size: 145 amino acids; 16559 Da
Caution: Due to a premature stop codon, the human protein is truncated and lacks the DNAJB3 canonical C-terminaldomain. However, expression studies suggest the existence of the mRNA and protein in human
1 PDB 3D structure from  and Proteopedia  for DNAJB3:2EJ7 (3D)
Explore the universe of human proteins at neXtProt for DNAJB3: NX_Q8WWF6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWF6
DNAJB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001394.1
Human Recombinant Protein Products:
DNAJB3 Antibody Products:
Assay Products for DNAJB3: |
Protein
Domains /
Families
for DNAJB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJB3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWF6ProtoNet protein and cluster: Q8WWF6 UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6Similarity: Contains 1 J domain |
Function
for DNAJB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6Function: May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAJB3 (NM_001001394) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031072 | heat shock protein binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
DNAJB3 for ontologies About GeneDecksing
|
Pathways & Interactions
for DNAJB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB3
4 Interacting proteins for DNAJB3 (Q8WWF62, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006457 | protein folding |
IEA | -- |
DNAJB3 for ontologies About GeneDecksing
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Drugs & Compounds
for DNAJB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJB3
Search CenterWatch for drugs/clinical trials and news about DNAJB3
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Transcripts
for DNAJB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJB3 gene: NM_001001394.3 Unigene Cluster for DNAJB3: DnaJ (Hsp40) homolog, subfamily B, member 3 Hs.725533 [show with all ESTs]Unigene Representative Sequence: AY0836652 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449667(uc002vuz.3) ENST00000446806
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAJB3 (NM_001001394) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB3 |
Additional cDNA sequence: AY083665.1 BC017590.2 BC024013.2 2 DOTS entries: DT.97782222 DT.97784082
GeneLoc Exon Structure
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Expression
for DNAJB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTATTAT
About this image
See DNAJB3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.725533
UniProtKB/Swiss-Prot: DNJB3_HUMAN, Q8WWF6Tissue specificity: Expressed in sperm (at protein level)
SABiosciences Custom PCR Arrays for DNAJB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DNAJB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB3 |
Orthologs
for DNAJB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for DNAJB3 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dnajb35 |
DnaJ (Hsp40) homolog, subfamily B, member 3 |
-- |
|
1 (44.55 cM) 88204732 |
ENSEMBL Gene Tree for DNAJB3 (if available)
TreeFam Gene Tree for DNAJB3 (if available) |
Paralogs
for DNAJB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNAJB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DNAJB3
6 CNVs: 37520 90341 35795 50416 63332 90340 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DNAJB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DNAJB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJB3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNAJB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction. (PubMed id 18184612)2 Meccariello R....Fasano S. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Structure of msj-1 gene: a comparative analysis. (PubMed id 15891074)1 Meccariello R....Fasano S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for DNAJB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DNAJB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing DNAJB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJB3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DNAJB3 gene:
Search GeneIP for patents involving DNAJB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAJB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJB3 | | | OriGene Protein Over-expression Lysate for DNAJB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJB3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DNAJB3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAJB3 | | OriGene Custom Protein Services for DNAJB3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJB3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB3 |
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 | | | DNAJB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for DNAJB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB3 |
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