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DNAJB2 Gene

protein-coding   GIFtS: 65
GCID: GC02P220143

DnaJ (Hsp40) Homolog, Subfamily B, Member 2


(Previous symbol: HSJ1)
  See DNAJB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 21 2     Heat Shock Protein J12 3
HSJ11 2 3 5     HSJ-12 3
HSPF32 3 5     DSMA52 5
DnaJ Protein Homolog 12 3     DnaJ Homolog Subfamily B Member 22
Heat Shock 40 KDa Protein 32 3     Heat Shock Protein, Neuronal DNAJ-Like 12

External Ids:    HGNC: 52281   Entrez Gene: 33002   Ensembl: ENSG000001359247   OMIM: 6041395   UniProtKB: P256863   
ORGUL members:         

Export aliases for DNAJB2 gene to outside databases

Previous GC identifers: GC02P218159 GC02P218865 GC02P220108 GC02P220346 GC02P219969 GC02P219852 GC02P211997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJB2 Gene:
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that
shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is
implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for DNAJB2 Gene:
DNAJB2 (DnaJ (Hsp40) homolog, subfamily B, member 2) is a protein-coding gene. Diseases associated with DNAJB2 include spinal muscular atrophy, distal, autosomal recessive, 5. GO annotations related to this gene include unfolded protein binding and Hsp70 protein binding. An important paralog of this gene is DNAJB4.

Gene Wiki entry for DNAJB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJB2 gene promoter:
         Sp1   p53   AREB6   CREB   CBF-A   CBF-B   SEF-1 (1)   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB2 promoter sequence
   Search Chromatin IP Primers for DNAJB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32-q34   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q32-q34

DNAJB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220143:  view genomic region     (about GC identifiers)

Start:
220,143,989 bp from pter      End:
220,151,622 bp from pter
Size:
7,634 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 2  
Size: 324 amino acids; 35580 Da
1 PDB 3D structure from and Proteopedia for DNAJB2:
2LGW (3D)    
Secondary accessions: A8K9P6 Q8IUK1 Q8IUK2 Q96F52
Alternative splicing: 2 isoforms:  P25686-3   P25686-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Ref.1 (AAA09035) sequence differs from that shown due to a frameshift in position 288)

Explore the universe of human proteins at neXtProt for DNAJB2: NX_P25686

Explore proteomics data for DNAJB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys39, Lys59
  • Modification sites at PhosphoSitePlus

  • See DNAJB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034639.1  NP_006727.2  

    ENSEMBL proteins: 
     ENSP00000338019   ENSP00000414796   ENSP00000375936   ENSP00000395173   ENSP00000375937  
     ENSP00000392790   ENSP00000387951  

    DNAJB2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DNAJB2
    OriGene MassSpec for DNAJB2
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    Novus Biologicals DNAJB2 Proteins
    Novus Biologicals DNAJB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DNAJB2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DNAJB2 

    DNAJB2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DNAJB2

    DNAJB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DNAJB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    3 InterPro protein domains:
     IPR003903 Ubiquitin-int_motif
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry P25686

    ProtoNet protein and cluster: P25686

    1 Blocks protein domain: IPB003903 Ubiquitin interacting motif

    UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686
    Similarity: Contains 1 J domain
    Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats


    Find genes that share domains with DNAJB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15936278
    GO:0030544Hsp70 protein binding IPI15936278
    GO:0031593polyubiquitin binding IDA15936278
    GO:0051082unfolded protein binding TAS1599432
    GO:0070628proteasome binding IDA15936278
         
    Find genes that share ontologies with DNAJB2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJB2:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJB2

    miRNA
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    miRTarBase miRNAs that target DNAJB2:
    hsa-mir-484 (MIRT042091)

    Block miRNA regulation of human, mouse, rat DNAJB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB2 (see all 42):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-29a hsa-miR-3921 hsa-miR-449a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJB2
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJB2 (NM_006736)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB2
    Addgene plasmids for DNAJB2 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJB2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502colocalizes with proteasome complex IDA15936278
    GO:0016234inclusion body IDA15936278

    Find genes that share ontologies with DNAJB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with DNAJB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNAJB2):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB2: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJB2 (P256862, 3 ENSP000003380194) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-4302843 MINT-4300099 I2D: score=3 STRING: ENSP00000365576
    SMAD4Q134852, 3MINT-61960 I2D: score=3 
    UBA52P629873, ENSP000003881074I2D: score=3 STRING: ENSP00000388107
    UBCP0CG483, ENSP000003448184I2D: score=3 STRING: ENSP00000344818
    RPS27AP629793, ENSP000002723174I2D: score=4 STRING: ENSP00000272317
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS1599432
    GO:0006986response to unfolded protein TAS1599432
    GO:0008219cell death IEA--
    GO:0008285negative regulation of cell proliferation IGI9553041
    GO:0030308negative regulation of cell growth IGI9553041

    Find genes that share ontologies with DNAJB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJB2 (DNJB2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJB2 gene (2 alternative transcripts): 
    NM_001039550.1  NM_006736.5  

    Unigene Cluster for DNAJB2:

    DnaJ (Hsp40) homolog, subfamily B, member 2
    Hs.77768  [show with all ESTs]
    Unigene Representative Sequence: NM_006736
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336576(uc002vkw.1 uc002vkx.1 uc010zlb.1) ENST00000425450
    ENST00000392086 ENST00000421532 ENST00000480537(uc010zla.1) ENST00000477917
    ENST00000482988 ENST00000392087 ENST00000442681 ENST00000439026 ENST00000481815
    ENST00000485220 ENST00000463463 ENST00000487855 ENST00000473750 ENST00000472019
    ENST00000476254 ENST00000470530
    miRNA
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    Block miRNA regulation of human, mouse, rat DNAJB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB2 (see all 42):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-29a hsa-miR-3921 hsa-miR-449a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJB2
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB2
    Clone
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    OriGene clones in human, mouse for DNAJB2 (see all 15)
    OriGene ORF clones in mouse, rat for DNAJB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJB2 (NM_006736)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB2
    Addgene plasmids for DNAJB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAJB2
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB2
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJB2
      QuantiFast Probe-based Assays in human, mouse, rat DNAJB2

    Additional mRNA sequence: 

    AK289626.1 AK292761.1 AK293888.1 AK296297.1 AK312723.1 BC047056.1 BT007088.1 S37374.1 
    S37375.1 

    20 DOTS entries:

    DT.100028343  DT.453092  DT.97845026  DT.100845663  DT.100845670  DT.99973454  DT.95252601  DT.100845672 
    DT.100845665  DT.100845673  DT.102824878  DT.91949590  DT.100845671  DT.121034371  DT.121034385  DT.121034401 
    DT.75161967  DT.91932865  DT.95228587  DT.95228609 

    Selected AceView cDNA sequences (see all 282):

    CD675988 BX280058 CR613430 AL565624 BU071215 BG250635 BQ961888 BC011609 
    BU735247 CR592152 CR592079 BC040494 BQ722253 CD171986 BM696728 CR610861 
    CR610990 AA452827 BI792973 BX463555 AI934720 BM694289 BM919866 CA314661 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                -           -     -           -     -                       -     -           -                             -               
    SP2:                                -           -     -           -     -                       -     -           -                                             
    SP3:                                -           -     -           -     -                       -     -           -     -                                       
    SP4:                                            -     -           -     -                                                                                       
    SP5:                                            -     -           -     -                                                                                       


    ECgene alternative splicing isoforms for DNAJB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTGCTTG
    DNAJB2 Expression
    About this image


    DNAJB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
     
     Testis (Reproductive System)
     
     Adrenal Gland (Endocrine System)
    DNAJB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77768

    UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686
    Tissue specificity: Brain (neuronal layers). Weakly, in skeletal muscle and spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB2: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJB2
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB2
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJB2
    QuantiFast Probe-based Assays in human, mouse, rat DNAJB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAJB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb21 , 5 DnaJ (Hsp40) homolog, subfamily B, member 21, 5 85.91(n)1
    85.19(a)1
      1 (38.64 cM)5
    568121  NM_001159883.11  NP_001153355.11 
     752364655 
    chicken
    (Gallus gallus)
    Aves DNAJB21 DnaJ (Hsp40) homolog, subfamily B, member 2 69.16(n)
    68.9(a)
      427022  XM_424624.4  XP_424624.4 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB26
    DnaJ (Hsp40) homolog, subfamily B, member 2
    64(a)
    1 ↔ 1
    1(95548451-95572222)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajb21 DnaJ (Hsp40) homolog, subfamily B, member 2 58.06(n)
    53.87(a)
      548454  NM_001015737.1  NP_001015737.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajb21 DnaJ (Hsp40) homolog, subfamily B, member 2 61.4(n)
    61.28(a)
      561686  NM_001079993.1  NP_001073462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mrj1 mrj 51.62(n)
    52.91(a)
      36797  NM_166152.3  NP_725541.1 


    ENSEMBL Gene Tree for DNAJB2 (if available)
    TreeFam Gene Tree for DNAJB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJB2 gene
    DNAJB42  DNAJB52  DNAJB132  DNAJB92  DNAJB62  DNAJB12  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    16 SIMAP similar genes for DNAJB2 using alignment to 7 protein entries:     DNJB2_HUMAN (see all proteins):
    DNAJB6    DNAJB3    DNAJA3    DNAJC1    DNAJC5B    DNAJB5
    DNAJB4    DNAJC17    DNAJC4    DNAJB8    DNAJA4    DNAJB7
    DNAJC18    DNAJB12    DNAJC24    ZCSL3

    Find genes that share paralogs with DNAJB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJB2 (see all 234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894761181,2
    --219522930(+) CAAGGG/TCCAGC 2 -- us2k10--------
    rs764531571,2
    C,F--219523009(+) CACAGG/CACAGC 2 -- us2k11Minor allele frequency- C:0.08WA 118
    rs790245201,2
    C,F--219523209(+) CAAAGT/CCCCAG 2 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1818939921,2
    C--219523421(+) CACGTC/GCGCCT 2 -- us2k10--------
    rs762474281,2
    C,F--219523424(+) GTCCGC/TCTCAA 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs797149361,2
    F--219523581(+) CAACCC/TTAGGC 2 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1422036051,2
    C--219523625(+) CAGAGA/GTTTTC 2 -- us2k10--------
    rs1865853651,2
    --219523633(+) TTCCCA/GAGTCT 2 -- us2k10--------
    rs1919508361,2
    --219523635(+) CCCAAC/GTCTCA 2 -- us2k10--------
    rs1467483051,2
    --219523716(+) TCTTAA/TCAAGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJB2 (220143989 - 220151622 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DNAJB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508885CNV Insertion20534489
    nsv834543CNV Loss17160897
    nsv527936CNV Loss19592680

    Human Gene Mutation Database (HGMD): DNAJB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB2
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604139   
    OMIM disorders: 614881  
    UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686
  • Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive
    neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy
    resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and
    cognition are not impaired. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for DNAJB2:    
    About MalaCards
    spinal muscular atrophy, distal, autosomal recessive, 5

    2 diseases from the University of Copenhagen DISEASES database for DNAJB2:
    Distal hereditary motor neuropathy     Kennedy's disease

    Find genes that share disorders with DNAJB2           About GenesLikeMe

    1 Novoseek inferred disease relationship for DNAJB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 27.3 1 17426712 (1)

    Genetic Association Database (GAD): DNAJB2
    Human Genome Epidemiology (HuGE) Navigator: DNAJB2 (2 documents)

    Export disorders for DNAJB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJB2 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with DNAJB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons. (PubMed id 1599432)1, 2, 3 Cheetham M.E.... Anderton B.H. (Biochem. J. 1992)
    2. A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation. (PubMed id 22522442)1, 2 Blumen S.C.... Viollet L. (Ann. Neurol. 2012)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Assignment of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32--&gt;q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids. (PubMed id 10516435)1, 3 Chapple J.P....Cheetham M.E. (Cytogenet. Cell Genet. 1999)
    8. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. (PubMed id 12754272)1, 9 Chapple J.P. and Cheetham M.E. (J. Biol. Chem. 2003)
    9. Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. (PubMed id 24023695)1 Novoselov S.S....Cheetham M.E. (PLoS ONE 2013)
    10. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3300 HGNC: 5228 AceView: DNAJB2 Ensembl:ENSG00000135924 euGenes: HUgn3300
    ECgene: DNAJB2 Kegg: 3300 H-InvDB: DNAJB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJB2 gene:
    Search GeneIP for patents involving DNAJB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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