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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB2 Gene

protein-coding   GIFtS: 62
GCID: GC02P220143

DnaJ (Hsp40) Homolog, Subfamily B, Member 2


(Previous symbol: HSJ1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 21 2     Heat Shock Protein J12 3
HSJ11 2 3 5     HSJ-12 3
HSPF32 3 5     DSMA52
DnaJ Protein Homolog 12 3     DnaJ Homolog Subfamily B Member 22
Heat Shock 40 KDa Protein 32 3     Heat Shock Protein, Neuronal DNAJ-Like 12

External Ids:    HGNC: 52281   Entrez Gene: 33002   Ensembl: ENSG000001359247   OMIM: 6041395   UniProtKB: P256863   

Export aliases for DNAJB2 gene to outside databases

Previous GC identifers: GC02P218159 GC02P218865 GC02P220108 GC02P220346 GC02P219969 GC02P219852 GC02P211997


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJB2 Gene:
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that
shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is
implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for DNAJB2 Gene: 
DNAJB2 (DnaJ (Hsp40) homolog, subfamily B, member 2) is a protein-coding gene. Diseases associated with DNAJB2 include young adult-onset distal hereditary motor neuropathy, and kennedy's disease. GO annotations related to this gene include unfolded protein binding and polyubiquitin binding. An important paralog of this gene is DNAJB4.

Gene Wiki entry for DNAJB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB2 gene promoter:
         Sp1   p53   AREB6   CREB   CBF-A   CBF-B   SEF-1 (1)   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32-q34   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q32-q34

DNAJB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220143:  view genomic region     (about GC identifiers)

Start:
220,143,989 bp from pter      End:
220,151,622 bp from pter
Size:
7,634 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 2  
Size: 324 amino acids; 35580 Da
1 PDB 3D structure from and Proteopedia for DNAJB2:
2LGW (3D)    
Secondary accessions: A8K9P6 Q8IUK1 Q8IUK2 Q96F52
Alternative splicing: 2 isoforms:  P25686-3   P25686-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Ref.1 (AAA09035) sequence differs from that shown due to a frameshift in position 288)

Explore the universe of human proteins at neXtProt for DNAJB2: NX_P25686

Explore proteomics data for DNAJB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25686

  • DNAJB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034639.1  NP_006727.2  

    ENSEMBL proteins: 
     ENSP00000338019   ENSP00000414796   ENSP00000375936   ENSP00000395173   ENSP00000375937  
     ENSP00000392790   ENSP00000387951  

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DNAJB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502colocalizes with proteasome complex IDA15936278
    GO:0016234inclusion body IDA15936278

    DNAJB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    3 InterPro protein domains:
     IPR003903 Ubiquitin-int_motif
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry P25686

    ProtoNet protein and cluster: P25686

    1 Blocks protein domain: IPB003903 Ubiquitin interacting motif

    UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686
    Similarity: Contains 1 J domain
    Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats


    DNAJB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15936278
    GO:0030544Hsp70 protein binding IPI15936278
    GO:0031593polyubiquitin binding IDA15936278
    GO:0051082unfolded protein binding TAS1599432
    GO:0070628proteasome binding IDA15936278
         
    DNAJB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJB2:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJB2 
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    SwitchGear 3'UTR luciferase reporter plasmidDNAJB2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNAJB2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for DNAJB2):
        Protein processing in endoplasmic reticulum


    DNAJB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/23 Interacting proteins for DNAJB2 (P256862, 3 ENSP000003380194) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-4302843 MINT-4300099 I2D: score=3 STRING: ENSP00000365576
    SMAD4Q134852, 3MINT-61960 I2D: score=3 
    UBA52P629873, ENSP000003881074I2D: score=3 STRING: ENSP00000388107
    UBCP0CG483, ENSP000003448184I2D: score=3 STRING: ENSP00000344818
    RPS27AP629793, ENSP000002723174I2D: score=4 STRING: ENSP00000272317
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS1599432
    GO:0006986response to unfolded protein TAS1599432
    GO:0008219cell death IEA--
    GO:0008285negative regulation of cell proliferation IGI9553041
    GO:0030308negative regulation of cell growth IGI9553041

    DNAJB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB2 (DNJB2)

    Search CenterWatch for drugs/clinical trials and news about DNAJB2 / DNJB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB2 gene (2 alternative transcripts): 
    NM_001039550.1  NM_006736.5  

    Unigene Cluster for DNAJB2:

    DnaJ (Hsp40) homolog, subfamily B, member 2
    Hs.77768  [show with all ESTs]
    Unigene Representative Sequence: NM_006736
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336576(uc002vkw.1 uc002vkx.1 uc010zlb.1) ENST00000425450
    ENST00000392086 ENST00000421532 ENST00000480537(uc010zla.1) ENST00000477917
    ENST00000482988 ENST00000392087 ENST00000442681 ENST00000439026 ENST00000481815
    ENST00000485220 ENST00000463463 ENST00000487855 ENST00000473750 ENST00000472019
    ENST00000476254 ENST00000470530
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB2 (see all 42):
    hsa-miR-1321 hsa-miR-3194-5p hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-29a hsa-miR-3921 hsa-miR-449a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK289626.1 AK292761.1 AK293888.1 AK296297.1 AK312723.1 BC047056.1 BT007088.1 S37374.1 
    S37375.1 

    20 DOTS entries:

    DT.100028343  DT.453092  DT.97845026  DT.100845663  DT.100845670  DT.99973454  DT.95252601  DT.100845672 
    DT.100845665  DT.100845673  DT.102824878  DT.91949590  DT.100845671  DT.121034371  DT.121034385  DT.121034401 
    DT.75161967  DT.91932865  DT.95228587  DT.95228609 

    24/282 AceView cDNA sequences (see all 282):

    CD675988 NM_006736 BX394879 AA580179 BM694289 AI669484 AI811133 BF344200 
    F07935 CR610990 AW081932 AL565624 BM559446 AI247284 BU735247 CK821106 
    BQ961888 CD171986 BG250635 BQ057451 CF121398 AA452827 AW197627 F02311 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                -           -     -           -     -                       -     -           -                             -               
    SP2:                                -           -     -           -     -                       -     -           -                                             
    SP3:                                -           -     -           -     -                       -     -           -     -                                       
    SP4:                                            -     -           -     -                                                                                       
    SP5:                                            -     -           -     -                                                                                       


    ECgene alternative splicing isoforms for DNAJB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTGCTTG
    DNAJB2 Expression
    About this image


    See DNAJB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB2

    SOURCE GeneReport for Unigene cluster: Hs.77768

    UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686
    Tissue specificity: Brain (neuronal layers). Weakly, in skeletal muscle and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJB2: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DNAJB2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb21 , 5 DnaJ (Hsp40) homolog, subfamily B, member 21, 5 85.91(n)1
    85.19(a)1
      1 (38.64 cM)5
    568121  NM_001159883.11  NP_001153355.11 
     752364655 
    chicken
    (Gallus gallus)
    Aves LOC4270221 dnaJ homolog subfamily B member 2-like 68.59(n)
    68.85(a)
      427022  XM_424624.3  XP_424624.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    57(a)
    52(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    1(95548451-95572222)
    1(95617787-95631929)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1532681 zgc:153268 57.67(n)
    55.56(a)
      561686  NM_001079993.1  NP_001073462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mrj6
    mrj
    27(a)
    1 → many
    2R(12090834-12109298)
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-246
    Protein DNJ-24
    34(a)
    1 → many
    III(5416135-5419565)


    ENSEMBL Gene Tree for DNAJB2 (if available)
    TreeFam Gene Tree for DNAJB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB2 gene
    DNAJB42  DNAJB52  DNAJB132  DNAJB92  DNAJB62  DNAJB12  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    16 SIMAP similar genes for DNAJB2 using alignment to 7 protein entries:     DNJB2_HUMAN (see all proteins):
    DNAJB3    DNAJB6    DNAJA3    DNAJC1    DNAJC5B    DNAJB5
    DNAJB4    DNAJC17    DNAJC4    DNAJB8    DNAJA4    DNAJB7
    DNAJC18    DNAJB12    DNAJC24    ZCSL3

    DNAJB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 SNPs in DNAJB2 are shown (see all 234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894761181,2
    --219522930(+) CAAGGG/TCCAGC 2 -- us2k10--------
    rs764531571,2
    C,F--219523009(+) CACAGG/CACAGC 2 -- us2k11Minor allele frequency- C:0.08WA 118
    rs790245201,2
    C,F--219523209(+) CAAAGT/CCCCAG 2 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1818939921,2
    C--219523421(+) CACGTC/GCGCCT 2 -- us2k10--------
    rs762474281,2
    C,F--219523424(+) GTCCGC/TCTCAA 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs797149361,2
    F--219523581(+) CAACCC/TTAGGC 2 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1422036051,2
    C--219523625(+) CAGAGA/GTTTTC 2 -- us2k10--------
    rs1865853651,2
    --219523633(+) TTCCCA/GAGTCT 2 -- us2k10--------
    rs1919508361,2
    --219523635(+) CCCAAC/GTCTCA 2 -- us2k10--------
    rs1467483051,2
    --219523716(+) TCTTAA/TCAAGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJB2 (220143989 - 220151622 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DNAJB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508885CNV Insertion20534489
    nsv834543CNV Loss17160897
    nsv527936CNV Loss19592680


    Human Gene Mutation Database (HGMD): DNAJB2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB2
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604139    OMIM disorders: --

    UniProtKB/Swiss-Prot: DNJB2_HUMAN, P25686
  • Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive
    neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy
    resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and
    cognition are not impaired. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for DNAJB2:    About MalaCards
    young adult-onset distal hereditary motor neuropathy    kennedy's disease    distal hereditary motor neuropathy    ectodermal dysplasia
    neuronitis    choroiditis    wilms tumor    huntington's disease
    neuropathy

    2 diseases from the University of Copenhagen DISEASES database for DNAJB2:
    Distal hereditary motor neuropathy     Kennedy's disease

    DNAJB2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DNAJB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 27.3 1 17426712 (1)

    Genetic Association Database (GAD): DNAJB2
    Human Genome Epidemiology (HuGE) Navigator: DNAJB2 (2 documents)

    Export disorders for DNAJB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB2 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with DNAJB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons. (PubMed id 1599432)1, 2, 3 Cheetham M.E.... Anderton B.H. (1992)
    2. A rare recessive distal hereditary motor neuropathy wi th HSJ1 chaperone mutation. (PubMed id 22522442)1, 2 Blumen S.C....Viollet L. (2012)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Assignment of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32-->q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids. (PubMed id 10516435)1, 3 Chapple J.P....Cheetham M.E. (1999)
    8. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. (PubMed id 12754272)1, 9 Chapple J.P. and Cheetham M.E. (2003)
    9. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3300 HGNC: 5228 AceView: DNAJB2 Ensembl:ENSG00000135924 euGenes: HUgn3300
    ECgene: DNAJB2 Kegg: 3300 H-InvDB: DNAJB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJB2 gene:
    Search GeneIP for patents involving DNAJB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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