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Aliases for DNAJB14 Gene

Aliases for DNAJB14 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 14 2 3
  • DnaJ Homolog Subfamily B Member 14 3
  • EGNR9427 3
  • PRO34683 3

External Ids for DNAJB14 Gene

Previous GeneCards Identifiers for DNAJB14 Gene

  • GC04M101178
  • GC04M101039
  • GC04M100817
  • GC04M096559

Summaries for DNAJB14 Gene

GeneCards Summary for DNAJB14 Gene

DNAJB14 (DnaJ (Hsp40) Homolog, Subfamily B, Member 14) is a Protein Coding gene. An important paralog of this gene is DNAJC18.

UniProtKB/Swiss-Prot for DNAJB14 Gene

  • Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER-associated degradation (ERAD) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB14 Gene

Genomics for DNAJB14 Gene

Regulatory Elements for DNAJB14 Gene

Genomic Location for DNAJB14 Gene

Start:
99,896,248 bp from pter
End:
99,946,726 bp from pter
Size:
50,479 bases
Orientation:
Minus strand

Genomic View for DNAJB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB14 Gene

Proteins for DNAJB14 Gene

  • Protein details for DNAJB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBM8-DJB14_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 14
    Protein Accession:
    Q8TBM8
    Secondary Accessions:
    • Q6UXN1
    • Q7Z3P0
    • Q86TA7
    • Q86TM0
    • Q9GZU9

    Protein attributes for DNAJB14 Gene

    Size:
    379 amino acids
    Molecular mass:
    42516 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA8/Hsc70.
    SequenceCaution:
    • Sequence=AAQ88639.1; Type=Erroneous termination; Positions=355; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAB14645.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14893.1; Type=Erroneous termination; Positions=190; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=CAD97796.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB14 Gene

Proteomics data for DNAJB14 Gene at MOPED

Post-translational modifications for DNAJB14 Gene

  • Ubiquitination at Lys166
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJB14 Gene

Domains for DNAJB14 Gene

Gene Families for DNAJB14 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJB14 Gene

Suggested Antigen Peptide Sequences for DNAJB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBM8

UniProtKB/Swiss-Prot:

DJB14_HUMAN :
  • Q8TBM8
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB14: view

Function for DNAJB14 Gene

Molecular function for DNAJB14 Gene

UniProtKB/Swiss-Prot Function: Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER-associated degradation (ERAD) pathway.

miRNA for DNAJB14 Gene

miRTarBase miRNAs that target DNAJB14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJB14 Gene

Localization for DNAJB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB14 Gene COMPARTMENTS Subcellular localization image for DNAJB14 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJB14: view

Pathways for DNAJB14 Gene

SuperPathways for DNAJB14 Gene

No Data Available

Interacting Proteins for DNAJB14 Gene

Gene Ontology (GO) - Biological Process for DNAJB14 Gene

None

No data available for Pathways by source for DNAJB14 Gene

Transcripts for DNAJB14 Gene

Unigene Clusters for DNAJB14 Gene

DnaJ (Hsp40) homolog, subfamily B, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for DNAJB14 Gene

GeneLoc Exon Structure for
DNAJB14
ECgene alternative splicing isoforms for
DNAJB14

Expression for DNAJB14 Gene

mRNA expression in normal human tissues for DNAJB14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB14 Gene

SOURCE GeneReport for Unigene cluster for DNAJB14 Gene Hs.577426

genes like me logo Genes that share expressions with DNAJB14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJB14 Gene

Orthologs for DNAJB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB14 35
  • 99.91 (n)
  • 100 (a)
DNAJB14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJB14 35
  • 94.81 (n)
  • 97.1 (a)
DNAJB14 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB14 35
  • 95.78 (n)
  • 97.89 (a)
DNAJB14 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb14 35
  • 85.93 (n)
  • 93.4 (a)
Dnajb14 16
Dnajb14 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB14 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb14 35
  • 84.7 (n)
  • 93.37 (a)
chicken
(Gallus gallus)
Aves DNAJB14 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb14 35
  • 70.77 (n)
  • 71.66 (a)
Str.16686 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3432 35
zebrafish
(Danio rerio)
Actinopterygii dnajb14 35
  • 65.69 (n)
  • 65.87 (a)
dnajb14 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001859 35
  • 48.26 (n)
  • 41.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30156 36
  • 23 (a)
ManyToMany
CG3061 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-1 36
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL190C 35
  • 52.19 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 35
  • 50.39 (n)
  • 41.86 (a)
HLJ1 36
  • 22 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01629g 35
  • 49.05 (n)
  • 42.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03335 35
  • 43.92 (n)
  • 34.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.05c 35
  • 46.7 (n)
  • 34.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5913 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for DNAJB14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB14 Gene

ENSEMBL:
Gene Tree for DNAJB14 (if available)
TreeFam:
Gene Tree for DNAJB14 (if available)

Paralogs for DNAJB14 Gene

Paralogs for DNAJB14 Gene

Selected SIMAP similar genes for DNAJB14 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DNAJB14 Gene

genes like me logo Genes that share paralogs with DNAJB14: view

Variants for DNAJB14 Gene

Sequence variations from dbSNP and Humsavar for DNAJB14 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs719305 -- 99,942,714(+) AGTGT(C/T)TTATG intron-variant
rs959720 -- 99,943,180(-) TCTGA(G/T)CCTTC intron-variant
rs1044044 -- 99,899,693(-) TACTC(A/G)GTTAA utr-variant-3-prime
rs1896166 -- 99,912,034(-) aactc(A/G)aaata intron-variant
rs2081626 -- 99,915,631(-) AAGAT(A/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB14 Gene

Variant ID Type Subtype PubMed ID
nsv879661 CNV Loss 21882294
nsv879662 CNV Loss 21882294
nsv879663 CNV Loss 21882294

Relevant External Links for DNAJB14 Gene

HapMap Linkage Disequilibrium report
DNAJB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB14 Gene

Disorders for DNAJB14 Gene

No disorders were found for DNAJB14 Gene.

No data available for UniProtKB/Swiss-Prot for DNAJB14 Gene

Publications for DNAJB14 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. (PMID: 23018488) Sopha P. … Kohno K. (Cell Struct. Funct. 2012) 3 4

Products for DNAJB14 Gene

Sources for DNAJB14 Gene

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