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Aliases for DNAJB14 Gene

Aliases for DNAJB14 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 14 2 3
  • EGNR9427 3
  • PRO34683 3

External Ids for DNAJB14 Gene

Previous GeneCards Identifiers for DNAJB14 Gene

  • GC04M101178
  • GC04M101039
  • GC04M100817
  • GC04M096559

Summaries for DNAJB14 Gene

GeneCards Summary for DNAJB14 Gene

DNAJB14 (DnaJ (Hsp40) Homolog, Subfamily B, Member 14) is a Protein Coding gene. An important paralog of this gene is DNAJC18.

UniProtKB/Swiss-Prot for DNAJB14 Gene

  • Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER-associated degradation (ERAD) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB14 Gene

Genomics for DNAJB14 Gene

Regulatory Elements for DNAJB14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJB14 Gene

Chromosome:
4
Start:
99,896,248 bp from pter
End:
99,946,726 bp from pter
Size:
50,479 bases
Orientation:
Minus strand

Genomic View for DNAJB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB14 Gene

Proteins for DNAJB14 Gene

  • Protein details for DNAJB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBM8-DJB14_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 14
    Protein Accession:
    Q8TBM8
    Secondary Accessions:
    • Q6UXN1
    • Q7Z3P0
    • Q86TA7
    • Q86TM0
    • Q9GZU9

    Protein attributes for DNAJB14 Gene

    Size:
    379 amino acids
    Molecular mass:
    42516 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA8/Hsc70.
    SequenceCaution:
    • Sequence=AAQ88639.1; Type=Erroneous termination; Positions=355; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAB14645.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14893.1; Type=Erroneous termination; Positions=190; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=CAD97796.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB14 Gene

Proteomics data for DNAJB14 Gene at MOPED

Post-translational modifications for DNAJB14 Gene

  • Ubiquitination at Lys 166
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJB14 Gene

Domains & Families for DNAJB14 Gene

Gene Families for DNAJB14 Gene

Protein Domains for DNAJB14 Gene

Suggested Antigen Peptide Sequences for DNAJB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBM8

UniProtKB/Swiss-Prot:

DJB14_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB14: view

Function for DNAJB14 Gene

Molecular function for DNAJB14 Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER-associated degradation (ERAD) pathway.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB14 Gene

Localization for DNAJB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB14 Gene COMPARTMENTS Subcellular localization image for DNAJB14 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DNAJB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJB14: view

Pathways & Interactions for DNAJB14 Gene

SuperPathways for DNAJB14 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Interacting Proteins for DNAJB14 Gene

Gene Ontology (GO) - Biological Process for DNAJB14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNAJB14 Gene

Drugs & Compounds for DNAJB14 Gene

No Compound Related Data Available

Transcripts for DNAJB14 Gene

Unigene Clusters for DNAJB14 Gene

DnaJ (Hsp40) homolog, subfamily B, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for DNAJB14 Gene

GeneLoc Exon Structure for
DNAJB14
ECgene alternative splicing isoforms for
DNAJB14

Expression for DNAJB14 Gene

mRNA expression in normal human tissues for DNAJB14 Gene

Protein differential expression in normal tissues from HIPED for DNAJB14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB14 Gene



SOURCE GeneReport for Unigene cluster for DNAJB14 Gene Hs.577426

genes like me logo Genes that share expression patterns with DNAJB14: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DNAJB14 Gene

Orthologs for DNAJB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJB14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJB14 35
  • 94.81 (n)
  • 97.1 (a)
DNAJB14 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB14 35
  • 95.78 (n)
  • 97.89 (a)
DNAJB14 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb14 35
  • 85.93 (n)
  • 93.4 (a)
Dnajb14 16
Dnajb14 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJB14 35
  • 99.91 (n)
  • 100 (a)
DNAJB14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb14 35
  • 84.7 (n)
  • 93.37 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB14 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB14 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb14 35
  • 70.77 (n)
  • 71.66 (a)
Str.16686 35
zebrafish
(Danio rerio)
Actinopterygii dnajb14 35
  • 65.69 (n)
  • 65.87 (a)
dnajb14 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3432 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001859 35
  • 48.26 (n)
  • 41.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30156 36
  • 23 (a)
ManyToMany
CG3061 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-1 36
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL190C 35
  • 52.19 (n)
  • 50 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01629g 35
  • 49.05 (n)
  • 42.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 35
  • 50.39 (n)
  • 41.86 (a)
HLJ1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5913 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03335 35
  • 43.92 (n)
  • 34.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.05c 35
  • 46.7 (n)
  • 34.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for DNAJB14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB14 Gene

ENSEMBL:
Gene Tree for DNAJB14 (if available)
TreeFam:
Gene Tree for DNAJB14 (if available)

Paralogs for DNAJB14 Gene

Paralogs for DNAJB14 Gene

(2) SIMAP similar genes for DNAJB14 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DNAJB14 Gene

genes like me logo Genes that share paralogs with DNAJB14: view

Variants for DNAJB14 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAJB14 Gene

Variant ID Type Subtype PubMed ID
nsv879661 CNV Loss 21882294
nsv879662 CNV Loss 21882294
nsv879663 CNV Loss 21882294

Variation tolerance for DNAJB14 Gene

Residual Variation Intolerance Score: 24.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB14 Gene

HapMap Linkage Disequilibrium report
DNAJB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DNAJB14 Gene

Disorders for DNAJB14 Gene

Relevant External Links for DNAJB14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB14
genes like me logo Genes that share disorders with DNAJB14: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB14 Gene

Publications for DNAJB14 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure. (PMID: 24732912) Goodwin E.C. … DiMaio D. (PLoS ONE 2014) 67
  4. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 67
  5. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. (PMID: 23018488) Sopha P. … Kohno K. (Cell Struct. Funct. 2012) 67

Products for DNAJB14 Gene

Sources for DNAJB14 Gene

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