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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB14 Gene

protein-coding   GIFtS: 44
GCID: GC04M100817

DnaJ (Hsp40) Homolog, Subfamily B, Member 14

  Search for DNAJB14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 141 2
EGNR94272
PRO346832
DnaJ Homolog Subfamily B Member 142

External Ids:    HGNC: 258811   Entrez Gene: 799822   Ensembl: ENSG000001640317   UniProtKB: Q8TBM83   

Export aliases for DNAJB14 gene to outside databases

Previous GC identifers: GC04M101178 GC04M101039 GC04M096559


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DNAJB14 Gene: 
DNAJB14 (DnaJ (Hsp40) homolog, subfamily B, member 14) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is ENSG00000257390.

UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8
Function: May act as a co-chaperone (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB14 gene promoter:
         HOXA9B   HOXA9   HTF   USF-1:USF-2   Nkx2-5   CREB   USF-1   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB14 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

DNAJB14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB14 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100817:  view genomic region     (about GC identifiers)

Start:
100,817,405 bp from pter      End:
100,867,883 bp from pter
Size:
50,479 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 14  
Size: 379 amino acids; 42516 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAQ88639.1; Type=Erroneous termination; Positions=355; Note=Translated as Arg;
Sequence=BAB14645.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14893.1;
Type=Erroneous termination; Positions=190; Note=Translated as Arg; Sequence=CAD97796.1; Type=Miscellaneous
discrepancy; Note=Intron retention;
Secondary accessions: Q6UXN1 Q7Z3P0 Q86TA7 Q86TM0 Q9GZU9
Alternative splicing: 2 isoforms:  Q8TBM8-1   Q8TBM8-2   

Explore the universe of human proteins at neXtProt for DNAJB14: NX_Q8TBM8

Explore proteomics data for DNAJB14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TBM8

  • DNAJB14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJB14 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001026893.1  NP_001265239.1  NP_001265240.1  

    ENSEMBL proteins: 
     ENSP00000404381   ENSP00000416179   ENSP00000335249   ENSP00000389471   ENSP00000390023  
     ENSP00000390019  

    Human Recombinant Protein Products for DNAJB14: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJB14 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    DNAJB14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    3 InterPro protein domains:
     IPR015399 DUF1977_DnaJ-like
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q8TBM8

    ProtoNet protein and cluster: Q8TBM8

    1 Blocks protein domain: IPB002052 N-6 Adenine-specific DNA methylase

    UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8
    Similarity: Contains 1 J domain


    DNAJB14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJB14_HUMAN, Q8TBM8
    Function: May act as a co-chaperone (By similarity)

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJB14 
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    hsa-miR-576-5p hsa-miR-610 hsa-miR-767-3p hsa-miR-548e hsa-miR-548v hsa-miR-500a hsa-miR-421 hsa-miR-3926
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB14 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB14

    5/6 Interacting proteins for DNAJB14 (Q8TBM83) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB14 (DJB14)

    Search CenterWatch for drugs/clinical trials and news about DNAJB14 / DJB14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB14 gene (4 alternative transcripts): 
    NM_024920.3  NM_001031723.3  NM_001278310.1  NM_001278311.1  

    Unigene Cluster for DNAJB14:

    DnaJ (Hsp40) homolog, subfamily B, member 14
    Hs.577426  [show with all ESTs]
    Unigene Representative Sequence: BX537609
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442697(uc003hvl.3 uc010ili.3) ENST00000420137(uc003hvk.3)
    ENST00000471101 ENST00000334223 ENST00000455208 ENST00000398991 ENST00000426476
    ENST00000474664 ENST00000493110 ENST00000471738 ENST00000469942(uc003hvm.3)

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB14 (see all 15):
    hsa-miR-576-5p hsa-miR-610 hsa-miR-767-3p hsa-miR-548e hsa-miR-548v hsa-miR-500a hsa-miR-421 hsa-miR-3926
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB14 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK023700.1 AK024343.1 AL833076.2 AL833412.1 AY186740.1 AY358272.1 BC022248.1 BX537609.1 

    15 DOTS entries:

    DT.100752064  DT.99939609  DT.100650987  DT.442065  DT.75131557  DT.121251105  DT.95160471  DT.91739987 
    DT.446128  DT.95362174  DT.102836614  DT.91669459  DT.91739984  DT.95361631  DT.100752063 

    24/221 AceView cDNA sequences (see all 221):

    BX509532 BG568897 AA579814 AW589433 CA848871 AI925600 AK023700 CA391400 
    AA419393 AA115553 AA310137 AA984520 BM699445 BM126656 CB241536 AA282968 
    AI761500 CA389132 AL833412 BG616416 BM679690 T39307 BU683588 CK818734 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB14    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                -     -     -           -         
    SP2:                                -                                 
    SP3:                                -     -     -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for DNAJB14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGAATTA
    DNAJB14 Expression
    About this image


    See DNAJB14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB14

    SOURCE GeneReport for Unigene cluster: Hs.577426
        SABiosciences Expression via Pathway-Focused PCR Array including DNAJB14: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNAJB14 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb141 , 5 DnaJ (Hsp40) homolog, subfamily B, member 141, 5 85.93(n)1
    93.4(a)1
      3 (63.94 cM)5
    706041  NM_001033155.11  NP_001028327.11 
     1378676755 
    chicken
    (Gallus gallus)
    Aves DNAJB146
    DnaJ (Hsp40) homolog, subfamily B, member 14
    82(a)
    1 ↔ 1
    4(59740223-59763189)
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB146
    --
    Uncharacterized protein
    83(a)
    73(a)
    1 ↔ many
    1 ↔ many
    GL343323.1(1025765-1046634)
    GL343324.1(860484-861331)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044298.12   -- 76.73(n)    BC044298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1536381 zgc:153638 65.78(n)
    65.33(a)
      792752  NM_001077787.1  NP_001071255.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30616
    CG301566
    (see all 3)
    --
    40(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(9858089-9860764)
    2R(2868951-2870491)
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-16
    dnj-266
    Protein DNJ-26
    36(a)
    18(a)
    1 ↔ many
    possible ortholog
    IV(11299008-11304787)
    IV(12251183-12252663)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HLJ16
    Co-chaperone for Hsp40p, anchored in the ER membra...
    26(a)
    1 → many
    XIII(577718-578392)


    ENSEMBL Gene Tree for DNAJB14 (if available)
    TreeFam Gene Tree for DNAJB14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB14 gene
    ENSG000002573902  DNAJB122  DNAJC142  DNAJC162  DNAJC182  
    2 SIMAP similar genes for DNAJB14 using alignment to 5 protein entries:     DJB14_HUMAN (see all proteins):
    DNAJB12    DNAJC18

    DNAJB14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DNAJB14
    PGOHUM00000246823


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/742 SNPs in DNAJB14 are shown (see all 742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872711981,2
    C--100820734(+) CAACAA/GATGCC 1 -- ut310--------
    rs561712571,2
    C--100820804(+) CATTCC/TCTCAC 1 -- ut310--------
    rs10440441,2
    C,F,A,H--100820850(-) TACTCG/AGTTAA 1 -- ut31 ese315Minor allele frequency- A:0.22EA MN NS NA WA CSA 1939
    rs1406788061,2
    C--100821089(+) TACTAC/TTCTAC 1 -- ut310--------
    rs1908524551,2
    --100821178(+) TTATAC/TGTTTA 1 -- ut310--------
    rs1829920831,2
    C--100821243(+) TATTAC/TTTATT 1 -- ut310--------
    rs559431421,2
    C--100821454(+) ATAGCC/TATTTC 1 -- ut310--------
    rs1875309231,2
    --100821466(+) TCATAA/TTTTCT 1 -- ut310--------
    rs1154325761,2
    F--100821487(+) TCAGTA/GTAGCA 1 -- ut311Minor allele frequency- G:0.01NA 120
    rs1902978841,2
    --100821879(+) AAAAAA/GTGGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DNAJB14 (100817405 - 100867883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DNAJB14:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv879663CNV Loss21882294
    nsv879661CNV Loss21882294
    nsv879662CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB14 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DNAJB14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. A novel mammalian ER-located J-protein, DNAJB14, can a ccelerate ERAD of misfolded membrane proteins. (PubMed id 23018488)1 Sopha P....Kohno K. (2012)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79982 HGNC: 25881 AceView: FLJ14281 Ensembl:ENSG00000164031 euGenes: HUgn79982
    ECgene: DNAJB14 H-InvDB: DNAJB14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNAJB14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJB14 gene:
    Search GeneIP for patents involving DNAJB14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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