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Aliases for DNAJB14 Gene

Aliases for DNAJB14 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B14 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 14 2 3
  • DnaJ Homolog Subfamily B Member 14 3
  • EGNR9427 3
  • PRO34683 3

External Ids for DNAJB14 Gene

Previous GeneCards Identifiers for DNAJB14 Gene

  • GC04M101178
  • GC04M101039
  • GC04M100817
  • GC04M096559

Summaries for DNAJB14 Gene

GeneCards Summary for DNAJB14 Gene

DNAJB14 (DnaJ Heat Shock Protein Family (Hsp40) Member B14) is a Protein Coding gene. Diseases associated with DNAJB14 include Long Qt Syndrome 1. An important paralog of this gene is DNAJB12.

UniProtKB/Swiss-Prot for DNAJB14 Gene

  • Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70s ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).

  • (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB14 Gene

Genomics for DNAJB14 Gene

Regulatory Elements for DNAJB14 Gene

Enhancers for DNAJB14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G099819 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +125.3 125295 3.2 TBP CTCF CBX3 TAL1 RAD21 CBX5 EED FOS ETV6 TRIM24 DNAJB14 TRMT10A DAPP1 H2AFZ MTTP LOC256880 LAMTOR3 DDIT4L LOC285556
GH04G099855 1.2 Ensembl ENCODE dbSUPER 20.3 +90.0 90026 3.0 CTCF IRF2 NFIB FOSL1 TRIM24 FOS MAFK TCF7L2 SMARCA5 MTA2 DNAJB14 DAPP1 LOC256880 H2AFZ ENSG00000279913 LAMTOR3
GH04G099893 1 ENCODE 23.4 +52.5 52476 2.3 PKNOX1 ATF1 ARID4B SIN3A YY1 ETS1 ELK1 KDM4B ZNF263 ZHX2 DNAJB14 LOC256880 H2AFZ TRMT10A MTTP DAPP1 LAMTOR3 ENSG00000279913
GH04G099862 0.8 dbSUPER 20.6 +83.0 83028 1.7 PKNOX1 TBL1XR1 INSM2 KLF17 FEZF1 FOSL1 ZNF664 NCOR1 FOS CREM DNAJB14 DAPP1 H2AFZ LOC256880 LAMTOR3 ENSG00000279913
GH04G099944 1.2 ENCODE 12.9 -1.4 -1426 6.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC DNAJB14 LAMTOR3 DAPP1 LOC256880
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB14 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171126 426 2201 PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for DNAJB14 Gene

Chromosome:
4
Start:
99,896,248 bp from pter
End:
99,946,726 bp from pter
Size:
50,479 bases
Orientation:
Minus strand

Genomic View for DNAJB14 Gene

Genes around DNAJB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB14 Gene

Proteins for DNAJB14 Gene

  • Protein details for DNAJB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBM8-DJB14_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 14
    Protein Accession:
    Q8TBM8
    Secondary Accessions:
    • Q6UXN1
    • Q7Z3P0
    • Q86TA7
    • Q86TM0
    • Q9GZU9

    Protein attributes for DNAJB14 Gene

    Size:
    379 amino acids
    Molecular mass:
    42516 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA8/Hsc70 (PubMed:23018488, PubMed:24732912, PubMed:27916661). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (PubMed:24675744).
    SequenceCaution:
    • Sequence=AAQ88639.1; Type=Erroneous termination; Positions=355; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAB14645.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14893.1; Type=Erroneous termination; Positions=190; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=CAD97796.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB14 Gene

Post-translational modifications for DNAJB14 Gene

  • Ubiquitination at Lys166
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJB14 Gene

Domains & Families for DNAJB14 Gene

Gene Families for DNAJB14 Gene

Protein Domains for DNAJB14 Gene

Suggested Antigen Peptide Sequences for DNAJB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBM8

UniProtKB/Swiss-Prot:

DJB14_HUMAN :
  • Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
Family:
  • Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
genes like me logo Genes that share domains with DNAJB14: view

Function for DNAJB14 Gene

Molecular function for DNAJB14 Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70s ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744).

Gene Ontology (GO) - Molecular Function for DNAJB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030544 Hsp70 protein binding IPI 27916661
genes like me logo Genes that share ontologies with DNAJB14: view

Phenotypes for DNAJB14 Gene

GenomeRNAi human phenotypes for DNAJB14:
genes like me logo Genes that share phenotypes with DNAJB14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB14 Gene

Localization for DNAJB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Localizes to the endoplasmic reticulum membrane (PubMed:23018488, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912). {ECO:0000269 PubMed:23018488, ECO:0000269 PubMed:24732912, ECO:0000269 PubMed:27916661}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB14 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
cytosol 4
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 27916661
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with DNAJB14: view

Pathways & Interactions for DNAJB14 Gene

SuperPathways for DNAJB14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043623 cellular protein complex assembly IDA 27916661
GO:0051085 chaperone mediated protein folding requiring cofactor IDA 27916661
GO:0070389 chaperone cofactor-dependent protein refolding IDA 27916661
genes like me logo Genes that share ontologies with DNAJB14: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB14 Gene

Drugs & Compounds for DNAJB14 Gene

No Compound Related Data Available

Transcripts for DNAJB14 Gene

Unigene Clusters for DNAJB14 Gene

DnaJ (Hsp40) homolog, subfamily B, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for DNAJB14 Gene

GeneLoc Exon Structure for
DNAJB14
ECgene alternative splicing isoforms for
DNAJB14

Expression for DNAJB14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB14 Gene

Protein differential expression in normal tissues from HIPED for DNAJB14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB14 Gene



NURSA nuclear receptor signaling pathways regulating expression of DNAJB14 Gene:

DNAJB14

SOURCE GeneReport for Unigene cluster for DNAJB14 Gene:

Hs.577426

Evidence on tissue expression from TISSUES for DNAJB14 Gene

  • Nervous system(4.6)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with DNAJB14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB14 Gene

Orthologs for DNAJB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB14 34 35
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia DNAJB14 34 35
  • 95.78 (n)
cow
(Bos Taurus)
Mammalia DNAJB14 34 35
  • 94.81 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dnajb14 34 16 35
  • 85.93 (n)
rat
(Rattus norvegicus)
Mammalia Dnajb14 34
  • 84.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB14 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB14 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb14 34
  • 70.77 (n)
Str.16686 34
zebrafish
(Danio rerio)
Actinopterygii dnajb14 34 35
  • 65.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3432 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001859 34
  • 48.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3061 35
  • 41 (a)
ManyToMany
CG30156 35
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-1 35
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL190C 34
  • 52.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 34 35
  • 50.39 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01629g 34
  • 49.05 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.05c 34
  • 46.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03335 34
  • 43.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5913 34
Species where no ortholog for DNAJB14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB14 Gene

ENSEMBL:
Gene Tree for DNAJB14 (if available)
TreeFam:
Gene Tree for DNAJB14 (if available)

Paralogs for DNAJB14 Gene

Paralogs for DNAJB14 Gene

(2) SIMAP similar genes for DNAJB14 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DNAJB14 Gene

genes like me logo Genes that share paralogs with DNAJB14: view

Variants for DNAJB14 Gene

Sequence variations from dbSNP and Humsavar for DNAJB14 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000004218 -- 99,942,295(+) TACTA(C/T)AGTGT intron-variant
rs1000081328 -- 99,908,114(+) GGAGT(C/T)TGATA intron-variant
rs1000091835 -- 99,913,524(+) AACTT(C/G)TATTG intron-variant
rs1000163952 -- 99,913,923(+) GGCTG(A/G)AAAGT intron-variant
rs1000210780 -- 99,919,234(+) ATGTA(C/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB14 Gene

Variant ID Type Subtype PubMed ID
nsv967775 CNV duplication 23825009

Variation tolerance for DNAJB14 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB14 Gene

Disorders for DNAJB14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJB14 Gene - From: GeneCards

Disorder Aliases PubMed IDs
long qt syndrome 1
  • long qt syndrome 1, acquired
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJB14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB14
genes like me logo Genes that share disorders with DNAJB14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB14 Gene

Publications for DNAJB14 Gene

  1. Tetrameric assembly of K(+) channels requires ER-located chaperone proteins. (PMID: 27916661) Li K. … Cai S.Q. (Mol. Cell 2017) 3 4 64
  2. Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure. (PMID: 24732912) Goodwin E.C. … DiMaio D. (PLoS ONE 2014) 3 4 64
  3. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. (PMID: 23018488) Sopha P. … Kohno K. (Cell Struct. Funct. 2012) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for DNAJB14 Gene

Sources for DNAJB14 Gene

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