Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJB14 Gene

Aliases for DNAJB14 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B14 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 14 2 3
  • DnaJ Homolog Subfamily B Member 14 3
  • EGNR9427 3
  • PRO34683 3

External Ids for DNAJB14 Gene

Previous GeneCards Identifiers for DNAJB14 Gene

  • GC04M101178
  • GC04M101039
  • GC04M100817
  • GC04M096559

Summaries for DNAJB14 Gene

GeneCards Summary for DNAJB14 Gene

DNAJB14 (DnaJ Heat Shock Protein Family (Hsp40) Member B14) is a Protein Coding gene. Diseases associated with DNAJB14 include Long Qt Syndrome 1. An important paralog of this gene is DNAJB12.

UniProtKB/Swiss-Prot for DNAJB14 Gene

  • Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER-associated degradation (ERAD) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB14 Gene

Genomics for DNAJB14 Gene

Regulatory Elements for DNAJB14 Gene

Enhancers for DNAJB14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F099893 1 ENCODE 23.4 +52.5 52476 2.3 PKNOX1 ATF1 ARID4B SIN3A ETS1 YY1 ELK1 KDM4B ZNF263 REST DNAJB14 LOC100507053 ADH5 H2AFZ LOC256880 ADH1B MTTP TRMT10A ADH1C DAPP1
GH04F099854 0.9 Ensembl ENCODE 20.3 +90.2 90226 3.4 SMARCA5 CTCF IRF2 ARID1B JUND ATF3 SMARCA4 IKZF1 FOS TRIM24 DNAJB14 DAPP1 LOC256880 H2AFZ LAMTOR3 ENSG00000279913
GH04F099944 1.2 ENCODE 12.9 -1.4 -1426 6.6 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 LAMTOR3 LINC01216 PCNAP1 LINC01218 FAM177A1P1 C4orf17 DNAJB14 DAPP1 LOC256880
GH04F099917 0.6 ENCODE 24 +27.8 27752 2.2 ATF3 CBX5 HNF4G MAFK RAD21 SETDB1 DNAJB14 LOC256880 H2AFZ DAPP1 LAMTOR3 ENSG00000279098
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB14 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001246169 526 2401 ATF1 PKNOX1 ARID4B SIN3A GLI4 DMAP1 ZNF48 YY1 GLIS2 ELK1

Genomic Location for DNAJB14 Gene

99,896,248 bp from pter
99,946,726 bp from pter
50,479 bases
Minus strand

Genomic View for DNAJB14 Gene

Genes around DNAJB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB14 Gene

Proteins for DNAJB14 Gene

  • Protein details for DNAJB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 14
    Protein Accession:
    Secondary Accessions:
    • Q6UXN1
    • Q7Z3P0
    • Q86TA7
    • Q86TM0
    • Q9GZU9

    Protein attributes for DNAJB14 Gene

    379 amino acids
    Molecular mass:
    42516 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA8/Hsc70.
    • Sequence=AAQ88639.1; Type=Erroneous termination; Positions=355; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAB14645.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14893.1; Type=Erroneous termination; Positions=190; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=CAD97796.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB14 Gene


neXtProt entry for DNAJB14 Gene

Post-translational modifications for DNAJB14 Gene

  • Ubiquitination at Lys 166
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DNAJB14
  • Santa Cruz Biotechnology (SCBT) Antibodies for DNAJB14

No data available for DME Specific Peptides for DNAJB14 Gene

Domains & Families for DNAJB14 Gene

Gene Families for DNAJB14 Gene

Protein Domains for DNAJB14 Gene

Suggested Antigen Peptide Sequences for DNAJB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB14: view

Function for DNAJB14 Gene

Molecular function for DNAJB14 Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER-associated degradation (ERAD) pathway.

Phenotypes for DNAJB14 Gene

GenomeRNAi human phenotypes for DNAJB14:
genes like me logo Genes that share phenotypes with DNAJB14: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB14 Gene

Localization for DNAJB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB14 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
nucleus 3
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJB14: view

Pathways & Interactions for DNAJB14 Gene

SuperPathways for DNAJB14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB14 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJB14 Gene

Transcripts for DNAJB14 Gene

Unigene Clusters for DNAJB14 Gene

DnaJ (Hsp40) homolog, subfamily B, member 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - - -
SP2: -
SP3: - - -

Relevant External Links for DNAJB14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJB14 Gene

Protein differential expression in normal tissues from HIPED for DNAJB14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB14 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJB14 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB14 Gene:

genes like me logo Genes that share expression patterns with DNAJB14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DNAJB14 Gene

Orthologs for DNAJB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJB14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJB14 34 35
  • 99.91 (n)
(Canis familiaris)
Mammalia DNAJB14 34 35
  • 95.78 (n)
(Bos Taurus)
Mammalia DNAJB14 34 35
  • 94.81 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
-- 35
  • 79 (a)
(Mus musculus)
Mammalia Dnajb14 34 16 35
  • 85.93 (n)
(Rattus norvegicus)
Mammalia Dnajb14 34
  • 84.7 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJB14 35
  • 66 (a)
(Gallus gallus)
Aves DNAJB14 35
  • 82 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
-- 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb14 34
  • 70.77 (n)
Str.16686 34
(Danio rerio)
Actinopterygii dnajb14 34 35
  • 65.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3432 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001859 34
  • 48.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3061 35
  • 41 (a)
CG30156 35
  • 23 (a)
(Caenorhabditis elegans)
Secernentea dnj-1 35
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL190C 34
  • 52.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 34 35
  • 50.39 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01629g 34
  • 49.05 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC17A3.05c 34
  • 46.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03335 34
  • 43.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5913 34
Species where no ortholog for DNAJB14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB14 Gene

Gene Tree for DNAJB14 (if available)
Gene Tree for DNAJB14 (if available)

Paralogs for DNAJB14 Gene

Paralogs for DNAJB14 Gene

(2) SIMAP similar genes for DNAJB14 Gene using alignment to 5 proteins: Pseudogenes for DNAJB14 Gene

genes like me logo Genes that share paralogs with DNAJB14: view

Variants for DNAJB14 Gene

Sequence variations from dbSNP and Humsavar for DNAJB14 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10014424 -- 99,943,207(+) TCACT(A/G)GTGAA intron-variant
rs10019138 -- 99,916,438(+) cctag(A/T)gaaaa intron-variant
rs1044044 -- 99,899,693(-) TACTC(A/G)GTTAA nc-transcript-variant, utr-variant-3-prime
rs10516458 -- 99,927,653(+) AGTTT(A/G)ACAGA intron-variant
rs10516459 -- 99,927,795(+) ATAAT(C/T)GTGCT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJB14 Gene

Variant ID Type Subtype PubMed ID
nsv967775 CNV duplication 23825009

Variation tolerance for DNAJB14 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB14 Gene

Disorders for DNAJB14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJB14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
long qt syndrome 1
  • long qt syndrome 1, acquired
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJB14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJB14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB14 Gene

Publications for DNAJB14 Gene

  1. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. (PMID: 23018488) Sopha P. … Kohno K. (Cell Struct. Funct. 2012) 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for DNAJB14 Gene

Sources for DNAJB14 Gene

Loading form....