DNAJB14 Gene
protein-coding GIFtS: 44
GCID: GC04M100817
|
|
DnaJ (Hsp40) homolog, subfamily B, member 14
| |
Aliases
for DNAJB14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily B, Member 141 2 | | FLJ142811 | | EGNR94272 | | PRO346832 | | DnaJ Homolog Subfamily B Member 142 |
Export aliases for DNAJB14 gene to outside databasesPrevious GC identifers: GC04M101178 GC04M101039 GC04M096559 |
Summaries
for DNAJB14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8Function: May act as a co-chaperone (By similarity)
|
Genomic Views
for DNAJB14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJB14 gene promoter:
HOXA9B HOXA9 HTF USF-1:USF-2 Nkx2-5 CREB USF-1 deltaCREB Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJB14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23DNAJB14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M100817: view genomic region
(about GC identifiers)
Start:
|
100,817,405 bp from pter |
End:
|
100,867,883 bp from pter |
Size:
|
50,479 bases |
Orientation:
|
minus strand |
|
Proteins
for DNAJB14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8 (See
protein sequence)Recommended Name: DnaJ homolog subfamily B member 14 Size: 379 amino acids; 42516 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAQ88639.1; Type=Erroneous termination; Positions=355; Note=Translated as Arg;Sequence=BAB14645.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14893.1;Type=Erroneous termination; Positions=190; Note=Translated as Arg; Sequence=CAD97796.1; Type=Miscellaneousdiscrepancy; Note=Intron retention;
Secondary accessions: Q6UXN1 Q7Z3P0 Q86TA7 Q86TM0 Q9GZU9Alternative splicing: 2 isoforms: Q8TBM8-1 Q8TBM8-2 Explore the universe of human proteins at neXtProt for DNAJB14: NX_Q8TBM8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBM8
DNAJB14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001026893.1
ENSEMBL proteins: ENSP00000404381 ENSP00000416179 ENSP00000335249 ENSP00000389471 ENSP00000390023 ENSP00000390019
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
DNAJB14 for ontologies About GeneDecksing
DNAJB14 Antibody Products:
Assay Products for DNAJB14: |
Protein
Domains /
Families
for DNAJB14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJB14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TBM8ProtoNet protein and cluster: Q8TBM8 1 Blocks protein family: IPB002052 N-6 Adenine-specific DNA methylase
UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8Similarity: Contains 1 J domain |
Function
for DNAJB14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DJB14_HUMAN, Q8TBM8Function: May act as a co-chaperone (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAJB14 (NM_001031723) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJB14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031072 | heat shock protein binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
DNAJB14 for ontologies About GeneDecksing
|
Pathways & Interactions
for DNAJB14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB14
1 Interacting protein for DNAJB14 (Q8TBM83) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- |
DNAJB14 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAJB14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJB14
Search CenterWatch for drugs/clinical trials and news about DNAJB14 / DJB14
|
Transcripts
for DNAJB14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJB14 gene (2 alternative transcripts): NM_024920.3 NM_001031723.2 Unigene Cluster for DNAJB14: DnaJ (Hsp40) homolog, subfamily B, member 14 Hs.577426 [show with all ESTs]Unigene Representative Sequence: BX53760911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000442697(uc003hvl.3 uc010ili.3) ENST00000420137(uc003hvk.3)
ENST00000471101 ENST00000334223 ENST00000455208 ENST00000398991 ENST00000426476
ENST00000474664 ENST00000493110 ENST00000471738 ENST00000469942(uc003hvm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAJB14 (NM_001031723) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJB14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB14 |
Additional cDNA sequence: AK023700.1 AK024343.1 AL833076.2 AL833412.1 AY186740.1 AY358272.1 BC022248.1 BX537609.1 15 DOTS entries: DT.100752064 DT.99939609 DT.100650987 DT.442065 DT.75131557 DT.121251105 DT.95160471 DT.91739987 DT.446128 DT.95362174 DT.102836614 DT.91669459 DT.91739984 DT.95361631 DT.100752063 24/221 AceView cDNA sequences (see all 221): BM678859 AA579814 BM982135 AU139724 AA310137 BG568897 AI561047 AI452488 T39316 AA984520 AA282903 BM126656 CA842797 AY358272 AA935638 AI126680 AL121021 BC022248 BM126921 BM744527 AA115553 CK818735 R28533 CA389131
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB14 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNAJB14
|
Expression
for DNAJB14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJB14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATGAATTA
About this image
See DNAJB14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJB14
SOURCE GeneReport for Unigene cluster: Hs.577426
SABiosciences Expression via Pathway-Focused PCR Array including DNAJB14: | Heat Shock Proteins & Chaperones in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJB14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJB14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB14 |
Orthologs
for DNAJB14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DNAJB14 gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for DNAJB14 (if available)
TreeFam Gene Tree for DNAJB14 (if available) |
Paralogs
for DNAJB14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DNAJB14 gene
- DNAJB122 DNAJC162 DNAJC182
2 SIMAP similar genes for DNAJB14 using alignment to 5 protein entries: DJB14_HUMAN (see all proteins):DNAJB12 DNAJC18
DNAJB14 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DNAJB14
PGOHUM00000246823
|
Genomic Variants
for DNAJB14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB14 |
|
Disorders
/ Diseases
for DNAJB14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJB14 for disorders About GeneDecksing
1  disease for DNAJB14: About MalaCardsmalaria
Export disorders for DNAJB14 gene to outside databases
|
Publications
for DNAJB14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJB14 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with DNAJB14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A novel mammalian ER-located J-protein, DNAJB14, can a ccelerate ERAD of misfolded membrane proteins. (PubMed id 23018488)1 Sopha P....Kohno K. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DNAJB14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNAJB14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJB14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJB14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DNAJB14 gene:
Search GeneIP for patents involving DNAJB14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJB14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAJB14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJB14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJB14 | | | OriGene Protein Over-expression Lysate for DNAJB14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJB14 | | OriGene 3'-UTR Clone for DNAJB14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAJB14 | | OriGene Custom Protein Services for DNAJB14 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJB14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB14 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DNAJB14 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DNAJB14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB14 |
|  |  |  | | | | Search ThermoFisher Antibodies for DNAJB14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB14 |
|
|
|
|
