Aliases for DNAJB14 Gene
External Ids for DNAJB14 Gene
Previous GeneCards Identifiers for DNAJB14 Gene
GeneCards Summary for DNAJB14 Gene
DNAJB14 (DnaJ Heat Shock Protein Family (Hsp40) Member B14) is a Protein Coding gene. Diseases associated with DNAJB14 include Structural Heart Defects And Renal Anomalies Syndrome. An important paralog of this gene is DNAJB12.
UniProtKB/Swiss-Prot for DNAJB14 Gene
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70s ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744).