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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNAJB13 Gene

protein-coding GIFtS: 46
GCID: GC11P073661

DnaJ (Hsp40) homolog, subfamily B, member 13

(Previous names: DnaJ (Hsp40) related, subfamily B, member 13 )

Explore 5 diseases affiliated with
DNAJB13 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 13¹ ²		1700014P03Rik²
TSARG6¹ ² ³		TSARG5²
RSPH16A¹ ²		DnaJ Homolog Subfamily B Member 13²
DnaJ (Hsp40) Related, Subfamily B, Member 13¹ ²		DnaJ-Like Protein²
Testis And Spermatogenesis Cell-Related Protein 6² ³		Radial Spoke 16 Homolog A²
Testis Spermatocyte Apoptosis-Related Gene 6 Protein² ³		Testis Spermatogenesis Apoptosis-Related Protein 6²
Testis Spermatogenesis Apoptosis-Related Gene 3 Protein² ³		TSARG3³
Testis Spermatogenesis Apoptosis-Related Gene 6 Protein² ³

External Ids:	HGNC: 30718¹	Entrez Gene: 374407²	Ensembl: ENSG00000187726⁷	OMIM: 610263⁵	UniProtKB: P59910³

Export aliases for DNAJB13 gene to outside databases

Previous GC identifers: GC11P073340 GC11P069957

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJB13:

DNAJA13 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ

family, see 608375.(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910

Function: May be involved in inhibiting testis spermatogenesis apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNAJB13 gene promoter:
AhR ATF-2 CUTL1 CREB Ik-2 HSF2 deltaCREB c-Myb c-Jun Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNAJB13 promoter sequence

Search SABiosciences Chromatin IP Primers for DNAJB13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3

DNAJB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB13 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P073661: view genomic region (about GC identifiers)

Start:	73,661,364 bp from pter	End:	73,681,411 bp from pter
Size:	20,048 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910 (See protein sequence)

Recommended Name: DnaJ homolog subfamily B member 13

Size: 316 amino acids; 36118 Da

Secondary accessions: B3LEP4 Q8IZW5

Alternative splicing: 2 isoforms: P59910-1 P59910-2

Explore the universe of human proteins at neXtProt for DNAJB13: NX_P59910

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P59910

DNAJB13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_705842.2

ENSEMBL proteins:

ENSP00000344431 ENSP00000439711 ENSP00000440778 ENSP00000438576

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	Uscn Proteins for DNAJB13

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

DNAJB13 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNAJB13 for domains About GeneDecksing

4 InterPro domains/families:

IPR008971 HSP40/DnaJ_pept-bd

IPR002939 DnaJ_C

IPR001623 DnaJ_domain

IPR018253 DnaJ_domain_CS

Graphical View of Domain Structure for InterPro Entry P59910

ProtoNet protein and cluster: P59910

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910

Similarity: Contains 1 J domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910

Function: May be involved in inhibiting testis spermatogenesis apoptosis

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0031072	heat shock protein binding	IEA	--
GO:0051082	unfolded protein binding	IEA	--

DNAJB13 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNAJB13

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for DNAJB13 (ENSP00000344431⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STIP1	ENSP00000305958⁴	STRING: ENSP00000305958

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IEA	--
GO:0006915	apoptotic process	IEP	12673577
GO:0007283	spermatogenesis	IEP	12673577

DNAJB13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNAJB13
Search CenterWatch for drugs/clinical trials and news about DNAJB13 / DJB13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for DNAJB13 gene:

NM_153614.2

Unigene Cluster for DNAJB13:

DnaJ (Hsp40) homolog, subfamily B, member 13

Hs.567888 [show with all ESTs]

Unigene Representative Sequence: AK128589

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000339764(uc001ouo.3) ENST00000535730 ENST00000537753 ENST00000542350

ENST00000543947

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Additional cDNA sequence:

AF516185.1 AK058095.1 AK128589.1 AY138810.2 AY325766.1 BC127689.1

3 DOTS entries:

DT.101979260 DT.101979259 DT.95291385

21 AceView cDNA sequences:

AF516185 NM_153614 AK058095 AY138810 CB124361 AF419291 BU859152 CA313968

AI217166 AK128589 BQ015829 CD358237 AW631065 CB048915 AI142754 AW188915

AI184534 AI214713 AI150079 AI811701 CB048914

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNAJB13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTGGTGG

About this image

DNAJB13 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Mature follicles (In-vitro growth and ...)

See DNAJB13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJB13

SOURCE GeneReport for Unigene cluster: Hs.567888

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910

Tissue specificity: Specifically expressed in testis

SABiosciences Expression via Pathway-Focused PCR Array including DNAJB13:

Heat Shock Proteins & Chaperones in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB13 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNAJB13¹	DnaJ (Hsp40) homolog, subfamily B, member 13	70.68(n) 69.3(a)		419060 XM_417251.3 XP_417251.3
lizard (Anolis carolinensis)	Reptilia	DNAJB13⁶	--	76(a)	1 ↔ 1	GL344128.1(41429-52696)
zebrafish (Danio rerio)	Actinopterygii	BM026049.1²	--	72.12(n)		BM026049.1
honey bee (Apis mellifera)	Insecta	--	--	10(a)	1 ↔ 1	GroupUn.711(60819-69103)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G08910⁶ AT2G20560⁶ (see all 11)	DNAJ heat shock protein-like protein (see all 11)	42(a) 41(a) (see all 11)	many ↔ many many ↔ many (see all 11)	3(2710154-2711895) 2(8848130-8850010)
rice (Oryza sativa)	Liliopsida	Os01g0239100¹	hypothetical protein	53.35(n) 48.88(a)		4326364 NM_001049078.1 NP_001042543.1

ENSEMBL Gene Tree for DNAJB13 (if available)
TreeFam Gene Tree for DNAJB13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNAJB13 gene

DNAJB4² DNAJC3² DNAJB5² DNAJB2² DNAJB9² DNAJC11² DNAJB6² DNAJC7²

DNAJB1² DNAJB7² DNAJB8²

7 SIMAP similar genes for DNAJB13 using alignment to 2 protein entries: DJB13_HUMAN (see all proteins):

DNAJB1 DNAJB4 DNAJB5 DNAJB8 DNAJB11 DNAJA1

DNAJA4

DNAJB13 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199562595^1,2		--	73666162(+)	`AAACT-/TATA TAAGG`	1	--	int¹		0	--	--	--	--
rs66885003^1,2	C,	--	73666163(+)	`AACTT-/ATATA AGGAA`	1	--	int¹		0	--	--	--	--
rs112955311^1,2		--	73666461(+)	`TGATTA/CTTCTG`	1	--	int¹		2		CSA	3
rs112362769^1,2		--	73666514(+)	`GTGCCC/TGGCTA`	1	--	int¹		1		CSA	2
rs189865654^1,2		--	73666520(+)	`GGCTAA/CTTTTT`	1	--	int¹		0	--	--	--	--
rs182185017^1,2		--	73666607(+)	`CCTCGC/GCCTCC`	1	--	int¹		0	--	--	--	--
rs35680747^1,2	C,	--	73667028(+)	`CCTGT-/CCGCAG`	1	--	int¹		1		NA	2
rs35925612^1,2	C,	--	73667140(+)	`TGCCC-/AGCACT`	1	--	int¹		1		NA	2
rs112136608^1,2	C,	--	73670794(+)	`TACTT-/TATTA TTTTA`	1	--	int¹		1		CSA	2
rs77465381^1,2	C,	--	73670795(+)	`ACTTTA/TTTATT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNAJB13 (73661364 - 73681411 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNAJB13: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB13

DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNAJB13 for disorders           About GeneDecksing

OMIM gene information: 610263    OMIM disorders: --

5 diseases for DNAJB13:    About MalaCards

cryptorchidism pneumonia tuberculosis malaria

mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for DNAJB13:

Cryptorchidism

Human Genome Epidemiology (HuGE) Navigator: DNAJB13 (1 document)

Export disorders for DNAJB13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNAJB13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNAJB13)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells. (PubMed id 12673577)^{1, 2} Liu G.... Li L. (2003)
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)¹ Shimada M....Tokunaga K. (2010)
Molecular cloning of TSARG6 gene related to apoptosis in human spermatogenic cells. (PubMed id 14970903)¹ Liu G....Xing X.W. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 374407	HGNC: 30718	AceView: TSARG6	Ensembl:ENSG00000187726	euGenes: HUgn374407
ECgene: DNAJB13	H-InvDB: DNAJB13

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DNAJB13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNAJB13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DNAJB13 gene:
Search GeneIP for patents involving DNAJB13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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DNAJB13 Gene

DnaJ (Hsp40) homolog, subfamily B, member 13

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DNAJB13 Gene

DnaJ (Hsp40) homolog, subfamily B, member 13

Aliasesfor DNAJB13 gene

Summariesfor DNAJB13 gene

Genomic Viewsfor DNAJB13 gene

Proteinsfor DNAJB13 gene

Protein Domains /Familiesfor DNAJB13 gene

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for DNAJB13 gene

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for DNAJB13 gene

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for DNAJB13 gene

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for DNAJB13 gene

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