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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB13 Gene

protein-coding   GIFtS: 46
GCID: GC11P073661

DnaJ (Hsp40) Homolog, Subfamily B, Member 13

(Previous names: DnaJ (Hsp40) related, subfamily B, member 13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 131 2     1700014P03Rik2
DnaJ (Hsp40) Related, Subfamily B, Member 131 2     RSPH16A2
Testis And Spermatogenesis Cell-Related Protein 62 3     TSARG52
Testis Spermatocyte Apoptosis-Related Gene 6 Protein2 3     DnaJ Homolog Subfamily B Member 132
Testis Spermatogenesis Apoptosis-Related Gene 3 Protein2 3     DnaJ-Like Protein2
Testis Spermatogenesis Apoptosis-Related Gene 6 Protein2 3     Radial Spoke 16 Homolog A2
TSARG62 3     Testis Spermatogenesis Apoptosis-Related Protein 62
Radial Spoke 16 Homolog A (Chlamydomonas)1     TSARG33

External Ids:    HGNC: 307181   Entrez Gene: 3744072   Ensembl: ENSG000001877267   OMIM: 6102635   UniProtKB: P599103   

Export aliases for DNAJB13 gene to outside databases

Previous GC identifers: GC11P073340 GC11P069957


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJB13 Gene:
DNAJA13 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the
DNAJ family, see 608375.(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAJB13 Gene: 
DNAJB13 (DnaJ (Hsp40) homolog, subfamily B, member 13) is a protein-coding gene. Diseases associated with DNAJB13 include cryptorchidism, and narcolepsy. GO annotations related to this gene include heat shock protein binding and molecular_function. An important paralog of this gene is DNAJB4.

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910
Function: May be involved in inhibiting testis spermatogenesis apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB13 gene promoter:
         AhR   ATF-2   CUTL1   CREB   Ik-2   HSF2   deltaCREB   c-Myb   c-Jun   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB13 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3

DNAJB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB13 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073661:  view genomic region     (about GC identifiers)

Start:
73,661,364 bp from pter      End:
73,681,411 bp from pter
Size:
20,048 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 13  
Size: 316 amino acids; 36118 Da
Secondary accessions: B3LEP4 Q8IZW5
Alternative splicing: 2 isoforms:  P59910-1   P59910-2   

Explore the universe of human proteins at neXtProt for DNAJB13: NX_P59910

Explore proteomics data for DNAJB13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59910

  • DNAJB13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJB13 Protein Expression
    REFSEQ proteins: NP_705842.2  
    ENSEMBL proteins: 
     ENSP00000344431   ENSP00000439711   ENSP00000440778   ENSP00000438576  

    Human Recombinant Protein Products for DNAJB13: 
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    Novus Biologicals DNAJB13 Protein
    Novus Biologicals DNAJB13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for DNAJB13 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    DNAJB13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry P59910

    ProtoNet protein and cluster: P59910

    UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910
    Similarity: Contains 1 J domain


    DNAJB13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJB13_HUMAN, P59910
    Function: May be involved in inhibiting testis spermatogenesis apoptosis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0051082unfolded protein binding IEA--
         
    DNAJB13 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJB13 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDNAJB13 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB13

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DNAJB13 (ENSP000003444314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STIP1ENSP000003059584STRING: ENSP00000305958
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--

    DNAJB13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB13 (DJB13)

    Search CenterWatch for drugs/clinical trials and news about DNAJB13 / DJB13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB13 gene: 
    NM_153614.2  

    Unigene Cluster for DNAJB13:

    DnaJ (Hsp40) homolog, subfamily B, member 13
    Hs.567888  [show with all ESTs]
    Unigene Representative Sequence: AK128589
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339764(uc001ouo.3) ENST00000535730 ENST00000537753 ENST00000542350
    ENST00000543947
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB13

    Additional mRNA sequence: 

    AF516185.1 AK058095.1 AK128589.1 AY138810.2 AY325766.1 BC127689.1 

    3 DOTS entries:

    DT.101979260  DT.101979259  DT.95291385 

    21 AceView cDNA sequences:

    AY138810 AK058095 AF516185 CB124361 NM_153614 AI217166 BQ015829 AK128589 
    BU859152 CD358237 AF419291 CA313968 AI142754 CB048915 AW631065 AI184534 
    AW188915 AI150079 AI214713 AI811701 CB048914 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB13 expression in normal human tissues (normalized intensities)      DNAJB13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTGGTGG
    DNAJB13 Expression
    About this image


    DNAJB13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus
             brain/hindbrain/4th ventricle   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Testis (Reproductive System)
     
     Epidermis (Integumentary System)

    See DNAJB13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB13

    SOURCE GeneReport for Unigene cluster: Hs.567888

    UniProtKB/Swiss-Prot: DJB13_HUMAN, P59910
    Tissue specificity: Specifically expressed in testis

        SABiosciences Expression via Pathway-Focused PCR Array including DNAJB13: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB13 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb131 , 5 DnaJ (Hsp40) related, subfamily B, member 131, 5 86.81(n)1
    89.87(a)1
      7 (54.36 cM)5
    693871  NM_153527.21  NP_705755.21 
     1005030185 
    chicken
    (Gallus gallus)
    Aves DNAJB131 DnaJ (Hsp40) homolog, subfamily B, member 13 70.68(n)
    69.3(a)
      419060  XM_417251.3  XP_417251.3 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB136
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL344128.1(41285-52696)
    zebrafish
    (Danio rerio)
    Actinopterygii BM026049.12   -- 72.12(n)    BM026049.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120206
    --
    31(a)
    1 ↔ 1
    3L(1797305-1798610)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIS16
    Type II HSP40 co-chaperone that interacts with the...
    28(a)
    1 → many
    XIV(618507-619565)
    rice
    (Oryza sativa)
    Liliopsida Os01g02391001 hypothetical protein 53.35(n)
    48.88(a)
      4326364  NM_001049078.1  NP_001042543.1 


    ENSEMBL Gene Tree for DNAJB13 (if available)
    TreeFam Gene Tree for DNAJB13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB13 gene
    DNAJB42  DNAJB52  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    5 SIMAP similar genes for DNAJB13 using alignment to 2 protein entries:     DJB13_HUMAN (see all proteins):
    DNAJB5    DNAJB4    DNAJB1    DNAJB8    DNAJB11

    DNAJB13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/527 SNPs in DNAJB13 are shown (see all 527)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449042701,2
    --69955151(+) ATACTC/TAACCA 1 -- us2k10--------
    rs118242941,2
    C,F,H--69955190(+) atgccA/Gcttta 1 -- us2k110Minor allele frequency- G:0.11NA WA CSA EA 374
    rs1858752601,2
    C--69955210(+) TATTGA/GCAAAC 1 -- us2k10--------
    rs1479389751,2
    --69955241(+) GAGTTC/GGTGAG 1 -- us2k10--------
    rs1417682101,2
    --69955358(+) ACCTCA/GTCTCT 1 -- us2k10--------
    rs1902518331,2
    --69955439(+) CAGGAA/GGATTG 1 -- us2k10--------
    rs353493791,2
    C,F--69955488(+) ATGATC/GGCACC 1 -- us2k15Minor allele frequency- G:0.07NA WA 244
    rs1825247781,2
    --69955489(+) TGATCA/GCACCA 1 -- us2k10--------
    rs1875728451,2
    --69955596(+) GCCAGC/TGTAAA 1 -- us2k10--------
    rs1905257551,2
    --69955648(+) GTGGGC/TGCATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJB13 (73661364 - 73681411 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DNAJB13:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1001380CNV Gain20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB13
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610263    OMIM disorders: --

    3 diseases for DNAJB13:    About MalaCards
    cryptorchidism    narcolepsy    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for DNAJB13:
    Cryptorchidism

    DNAJB13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNAJB13
    Human Genome Epidemiology (HuGE) Navigator: DNAJB13 (1 document)

    Export disorders for DNAJB13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB13 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DNAJB13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    2. Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells. (PubMed id 12673577)1, 2 Liu G.... Li L. (2003)
    3. Molecular cloning of TSARG6 gene related to apoptosis in human spermatogenic cells. (PubMed id 14970903)1 Liu G....Xing X.W. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374407 HGNC: 30718 AceView: TSARG6 Ensembl:ENSG00000187726 euGenes: HUgn374407
    ECgene: DNAJB13 H-InvDB: DNAJB13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJB13 gene:
    Search GeneIP for patents involving DNAJB13

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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