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Aliases for DNAJB13 Gene

Aliases for DNAJB13 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B13 2 3 5
  • Testis Spermatogenesis Apoptosis-Related Gene 3 Protein 3 4
  • Testis Spermatogenesis Apoptosis-Related Gene 6 Protein 3 4
  • Testis Spermatocyte Apoptosis-Related Gene 6 Protein 3 4
  • Testis And Spermatogenesis Cell-Related Protein 6 3 4
  • DnaJ (Hsp40) Related, Subfamily B, Member 13 2 3
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 13 2 3
  • TSARG6 3 4
  • Testis Spermatogenesis Apoptosis-Related Protein 6 3
  • Radial Spoke 16 Homolog A (Chlamydomonas) 2
  • Radial Spoke 16 Homolog A 3
  • DnaJ-Like Protein 3
  • RSPH16A 3
  • TSARG5 3
  • TSARG3 4

External Ids for DNAJB13 Gene

Previous GeneCards Identifiers for DNAJB13 Gene

  • GC11P073340
  • GC11P073661
  • GC11P069957

Summaries for DNAJB13 Gene

Entrez Gene Summary for DNAJB13 Gene

  • DNAJA13 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ family, see 608375.[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJB13 Gene

DNAJB13 (DnaJ Heat Shock Protein Family (Hsp40) Member B13) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB13 Gene

  • May be involved in inhibiting testis spermatogenesis apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB13 Gene

Genomics for DNAJB13 Gene

Regulatory Elements for DNAJB13 Gene

Genomic Location for DNAJB13 Gene

Chromosome:
11
Start:
73,950,319 bp from pter
End:
73,970,366 bp from pter
Size:
20,048 bases
Orientation:
Plus strand

Genomic View for DNAJB13 Gene

Genes around DNAJB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB13 Gene

Proteins for DNAJB13 Gene

  • Protein details for DNAJB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59910-DJB13_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 13
    Protein Accession:
    P59910
    Secondary Accessions:
    • B3LEP4
    • Q8IZW5

    Protein attributes for DNAJB13 Gene

    Size:
    316 amino acids
    Molecular mass:
    36118 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNAJB13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB13 Gene

Proteomics data for DNAJB13 Gene at MOPED

Post-translational modifications for DNAJB13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB13 Gene

Antibody Products

No data available for DME Specific Peptides for DNAJB13 Gene

Domains & Families for DNAJB13 Gene

Gene Families for DNAJB13 Gene

Protein Domains for DNAJB13 Gene

Suggested Antigen Peptide Sequences for DNAJB13 Gene

Graphical View of Domain Structure for InterPro Entry

P59910

UniProtKB/Swiss-Prot:

DJB13_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB13: view

Function for DNAJB13 Gene

Molecular function for DNAJB13 Gene

UniProtKB/Swiss-Prot Function:
May be involved in inhibiting testis spermatogenesis apoptosis.

Gene Ontology (GO) - Molecular Function for DNAJB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DNAJB13: view

Phenotypes for DNAJB13 Gene

genes like me logo Genes that share phenotypes with DNAJB13: view

Animal Model Products

CRISPR Products

miRNA for DNAJB13 Gene

miRTarBase miRNAs that target DNAJB13

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB13 Gene

Localization for DNAJB13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB13 Gene COMPARTMENTS Subcellular localization image for DNAJB13 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJB13 Gene

Pathways & Interactions for DNAJB13 Gene

SuperPathways for DNAJB13 Gene

No Data Available

Interacting Proteins for DNAJB13 Gene

Gene Ontology (GO) - Biological Process for DNAJB13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNAJB13 Gene

Drugs & Compounds for DNAJB13 Gene

No Compound Related Data Available

Transcripts for DNAJB13 Gene

Unigene Clusters for DNAJB13 Gene

DnaJ (Hsp40) homolog, subfamily B, member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB13 Gene

No ASD Table

Relevant External Links for DNAJB13 Gene

GeneLoc Exon Structure for
DNAJB13
ECgene alternative splicing isoforms for
DNAJB13

Expression for DNAJB13 Gene

mRNA expression in normal human tissues for DNAJB13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB13 Gene

This gene is overexpressed in Testis (x10.3), Cervix - Endocervix (x8.3), and Fallopian Tube (x7.5).

Protein differential expression in normal tissues from HIPED for DNAJB13 Gene

This gene is overexpressed in Neutrophil (60.9) and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB13 Gene



SOURCE GeneReport for Unigene cluster for DNAJB13 Gene Hs.567888

mRNA Expression by UniProt/SwissProt for DNAJB13 Gene

P59910-DJB13_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with DNAJB13: view

Protein tissue co-expression partners for DNAJB13 Gene

Primer Products

In Situ Assay Products

Orthologs for DNAJB13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJB13 35
  • 89.45 (n)
  • 92.09 (a)
DNAJB13 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB13 35
  • 89.87 (n)
  • 93.67 (a)
DNAJB13 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb13 35
  • 86.81 (n)
  • 89.87 (a)
Dnajb13 16
Dnajb13 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb13 35
  • 88.29 (n)
  • 91.46 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJB13 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB13 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB13 35
  • 70.68 (n)
  • 69.3 (a)
DNAJB13 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB13 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb13 35
  • 68.78 (n)
  • 70.89 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajb13 35
  • 62.13 (n)
  • 62.03 (a)
dnajb13 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12020 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08910 35
  • 52.97 (n)
  • 46.93 (a)
rice
(Oryza sativa)
Liliopsida Os02g0306900 35
  • 52.06 (n)
  • 47.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14203 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for DNAJB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB13 Gene

ENSEMBL:
Gene Tree for DNAJB13 (if available)
TreeFam:
Gene Tree for DNAJB13 (if available)

Paralogs for DNAJB13 Gene

(5) SIMAP similar genes for DNAJB13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJB13: view

Variants for DNAJB13 Gene

Sequence variations from dbSNP and Humsavar for DNAJB13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs589295 -- 73,961,142(-) CCACC(A/G)TTCCT intron-variant
rs608051 -- 73,962,361(-) TTCAT(C/G)CATCT intron-variant
rs603702 -- 73,962,035(-) CAGGC(A/G)GATCA intron-variant
rs634771 -- 73,957,797(-) AGAGG(A/G)CCGGA intron-variant, utr-variant-5-prime
rs605442 -- 73,962,395(-) TGCTC(A/G)TCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB13 Gene

Variant ID Type Subtype PubMed ID
esv1001380 CNV Gain 20482838

Variation tolerance for DNAJB13 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.64; 86.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB13 Gene

HapMap Linkage Disequilibrium report
DNAJB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB13 Gene

Disorders for DNAJB13 Gene

Relevant External Links for DNAJB13

Genetic Association Database (GAD)
DNAJB13
Human Genome Epidemiology (HuGE) Navigator
DNAJB13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB13

No disorders were found for DNAJB13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB13 Gene

Publications for DNAJB13 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Molecular cloning of TSARG6 gene related to apoptosis in human spermatogenic cells. (PMID: 14970903) Liu G. … Xing X.W. (Acta Biochim. Biophys. Sin. (Shanghai) 2004) 3
  4. Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells. (PMID: 12673577) Liu G. … Li L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003) 3

Products for DNAJB13 Gene

Sources for DNAJB13 Gene

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