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Aliases for DNAJB12 Gene

Aliases for DNAJB12 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 12 2 3
  • DJ10 3 6
  • DnaJ Homolog Subfamily B Member 12 3
  • FLJ0027 6

External Ids for DNAJB12 Gene

Previous GeneCards Identifiers for DNAJB12 Gene

  • GC10M072872
  • GC10M073196
  • GC10M073986
  • GC10M073438
  • GC10M073762
  • GC10M074092
  • GC10M068086

Summaries for DNAJB12 Gene

Entrez Gene Summary for DNAJB12 Gene

  • DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJB12 Gene

DNAJB12 (DnaJ (Hsp40) Homolog, Subfamily B, Member 12) is a Protein Coding gene. Diseases associated with DNAJB12 include choroideremia. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is DNAJC18.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB12 Gene

Genomics for DNAJB12 Gene

Regulatory Elements for DNAJB12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJB12 Gene

72,332,830 bp from pter
72,355,230 bp from pter
22,401 bases
Minus strand

Genomic View for DNAJB12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB12 Gene

Proteins for DNAJB12 Gene

  • Protein details for DNAJB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 12
    Protein Accession:
    Secondary Accessions:
    • B7Z7I3
    • Q9H6H0

    Protein attributes for DNAJB12 Gene

    375 amino acids
    Molecular mass:
    41819 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15289.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH13619.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJB12 Gene

    Alternative splice isoforms for DNAJB12 Gene


neXtProt entry for DNAJB12 Gene

Proteomics data for DNAJB12 Gene at MOPED

Post-translational modifications for DNAJB12 Gene

  • Ubiquitination at Lys141
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJB12 Gene

Antibody Products

No data available for DME Specific Peptides for DNAJB12 Gene

Domains for DNAJB12 Gene

Gene Families for DNAJB12 Gene

Protein Domains for DNAJB12 Gene

Suggested Antigen Peptide Sequences for DNAJB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB12: view

Function for DNAJB12 Gene

Animal Model Products

CRISPR Products

miRNA for DNAJB12 Gene

miRTarBase miRNAs that target DNAJB12

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB12 Gene

Localization for DNAJB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB12 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DNAJB12 Gene COMPARTMENTS Subcellular localization image for DNAJB12 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJB12: view

Pathways for DNAJB12 Gene

genes like me logo Genes that share pathways with DNAJB12: view

Pathways by source for DNAJB12 Gene

1 KEGG pathway for DNAJB12 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJB12 Gene


Transcripts for DNAJB12 Gene

Unigene Clusters for DNAJB12 Gene

DnaJ (Hsp40) homolog, subfamily B, member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: -

Relevant External Links for DNAJB12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB12 Gene

mRNA expression in normal human tissues for DNAJB12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DNAJB12 Gene

This gene is overexpressed in Bone (25.4), Breast (16.9), and Lung (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAJB12 Gene

SOURCE GeneReport for Unigene cluster for DNAJB12 Gene Hs.500013

genes like me logo Genes that share expressions with DNAJB12: view

Expression partners for DNAJB12 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJB12 Gene

Orthologs for DNAJB12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJB12 35
  • 89.16 (n)
  • 92.08 (a)
DNAJB12 36
  • 91 (a)
(Canis familiaris)
Mammalia DNAJB12 35
  • 91.58 (n)
  • 96.24 (a)
DNAJB12 36
  • 96 (a)
(Mus musculus)
Mammalia Dnajb12 35
  • 88.98 (n)
  • 94.4 (a)
Dnajb12 16
Dnajb12 36
  • 94 (a)
(Pan troglodytes)
Mammalia DNAJB12 35
  • 99.43 (n)
  • 99.51 (a)
DNAJB12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajb12 35
  • 88.47 (n)
  • 93.57 (a)
(Monodelphis domestica)
Mammalia DNAJB12 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJB12 36
  • 88 (a)
(Gallus gallus)
Aves DNAJB12 35
  • 76.74 (n)
  • 81.55 (a)
DNAJB12 36
  • 74 (a)
(Anolis carolinensis)
Reptilia DNAJB12 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb12 35
  • 69.88 (n)
  • 76.94 (a)
Str.10798 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22300 35
(Danio rerio)
Actinopterygii dnajb12a 35
  • 65.31 (n)
  • 68.75 (a)
wufc16f06 35
dnajb12a 36
  • 67 (a)
dnajb12b 36
  • 62 (a)
dnajb12b 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13337 35
fruit fly
(Drosophila melanogaster)
Insecta CG3061 37
  • 40 (a)
CG3061 35
  • 53.85 (n)
  • 47.11 (a)
CG30156 36
  • 26 (a)
CG3061 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001810 35
  • 50.99 (n)
  • 43.63 (a)
(Caenorhabditis elegans)
Secernentea dnj-1 35
  • 47.04 (n)
  • 44.44 (a)
dnj-1 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 36
  • 24 (a)
HLJ1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57340 35
  • 46.69 (n)
  • 37.31 (a)
(Oryza sativa)
Liliopsida Os01g0556400 35
  • 50.87 (n)
  • 40.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for DNAJB12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB12 Gene

Gene Tree for DNAJB12 (if available)
Gene Tree for DNAJB12 (if available)

Paralogs for DNAJB12 Gene

Paralogs for DNAJB12 Gene Pseudogenes for DNAJB12 Gene

genes like me logo Genes that share paralogs with DNAJB12: view

Variants for DNAJB12 Gene

Sequence variations from dbSNP and Humsavar for DNAJB12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs870594 -- 72,335,210(-) GGTGG(C/T)GGCAG utr-variant-3-prime, intron-variant
rs1062747 -- 72,334,877(-) AGGTT(A/C)TTCTC utr-variant-3-prime, intron-variant
rs1879471 -- 72,334,907(+) TTCTC(C/T)GGGCT utr-variant-3-prime, intron-variant
rs3183629 -- 72,334,176(-) atgcg(C/T)gtata utr-variant-3-prime, downstream-variant-500B
rs3750784 - 72,336,620(+) GTACT(C/T)TTCGG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB12 Gene

Variant ID Type Subtype PubMed ID
nsv895721 CNV Gain 21882294

Relevant External Links for DNAJB12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB12 Gene

Disorders for DNAJB12 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNAJB12 Gene in MalaCards »

(1) Disease for DNAJB12 Gene

(3) University of Copenhagen DISEASES for DNAJB12 Gene

genes like me logo Genes that share disorders with DNAJB12: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for DNAJB12 Gene

Publications for DNAJB12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for DNAJB12 Gene

Sources for DNAJB12 Gene

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