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Aliases for DNAJB12 Gene

Aliases for DNAJB12 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 12 2 3
  • DJ10 3 6
  • DnaJ Homolog Subfamily B Member 12 3
  • FLJ0027 6

External Ids for DNAJB12 Gene

Summaries for DNAJB12 Gene

Entrez Gene Summary for DNAJB12 Gene

  • DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJB12 Gene

DNAJB12 (DnaJ (Hsp40) Homolog, Subfamily B, Member 12) is a Protein Coding gene. Diseases associated with DNAJB12 include choroideremia. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is DNAJC18.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB12 Gene

Genomics for DNAJB12 Gene

Genomic Location for DNAJB12 Gene

Start:
72,332,830 bp from pter
End:
72,355,230 bp from pter
Size:
22,401 bases
Orientation:
Minus strand

Genomic View for DNAJB12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB12 Gene

Regulatory Elements for DNAJB12 Gene

Proteins for DNAJB12 Gene

  • Protein details for DNAJB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXW2-DJB12_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 12
    Protein Accession:
    Q9NXW2
    Secondary Accessions:
    • B7Z7I3
    • Q9H6H0

    Protein attributes for DNAJB12 Gene

    Size:
    375 amino acids
    Molecular mass:
    41819 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15289.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH13619.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJB12 Gene

    Alternative splice isoforms for DNAJB12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB12 Gene

Proteomics data for DNAJB12 Gene at MOPED

Post-translational modifications for DNAJB12 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys141

Other Protein References for DNAJB12 Gene

No data available for DME Specific Peptides for DNAJB12 Gene

Domains for DNAJB12 Gene

Gene Families for DNAJB12 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJB12 Gene

UniProtKB/Swiss-Prot:

DJB12_HUMAN
Domain:
  • Contains 1 J domain.:
    • Q9NXW2
genes like me logo Genes that share domains with DNAJB12: view

Function for DNAJB12 Gene

miRNA for DNAJB12 Gene

miRTarBase miRNAs that target DNAJB12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJB12 Gene

Localization for DNAJB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB12 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB12 Gene COMPARTMENTS Subcellular localization image for DNAJB12 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJB12: view

Pathways for DNAJB12 Gene

genes like me logo Genes that share pathways with DNAJB12: view

Pathways by source for DNAJB12 Gene

1 KEGG pathway for DNAJB12 Gene

Gene Ontology (GO) - Biological Process for DNAJB12 Gene

None

Transcripts for DNAJB12 Gene

Unigene Clusters for DNAJB12 Gene

DnaJ (Hsp40) homolog, subfamily B, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: -
SP7:

Relevant External Links for DNAJB12 Gene

GeneLoc Exon Structure for
DNAJB12
ECgene alternative splicing isoforms for
DNAJB12

Expression for DNAJB12 Gene

mRNA expression in normal human tissues for DNAJB12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAJB12 Gene

SOURCE GeneReport for Unigene cluster for DNAJB12 Gene Hs.500013

genes like me logo Genes that share expressions with DNAJB12: view

Orthologs for DNAJB12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB12 36
  • 99.43 (n)
  • 99.51 (a)
DNAJB12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJB12 36
  • 89.16 (n)
  • 92.08 (a)
DNAJB12 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB12 36
  • 91.58 (n)
  • 96.24 (a)
DNAJB12 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb12 36
  • 88.98 (n)
  • 94.4 (a)
Dnajb12 16
Dnajb12 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJB12 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB12 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb12 36
  • 88.47 (n)
  • 93.57 (a)
chicken
(Gallus gallus)
Aves DNAJB12 36
  • 76.74 (n)
  • 81.55 (a)
DNAJB12 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB12 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22300 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb12 36
  • 69.88 (n)
  • 76.94 (a)
Str.10798 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13337 36
zebrafish
(Danio rerio)
Actinopterygii dnajb12a 36
  • 65.31 (n)
  • 68.75 (a)
dnajb12a 37
  • 67 (a)
OneToMany
dnajb12b 37
  • 62 (a)
OneToMany
dnajb12b 37
  • 67 (a)
OneToMany
wufc16f06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001810 36
  • 50.99 (n)
  • 43.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30156 37
  • 26 (a)
ManyToMany
CG3061 36
  • 53.85 (n)
  • 47.11 (a)
CG3061 37
  • 42 (a)
ManyToMany
CG3061 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-1 36
  • 47.04 (n)
  • 44.44 (a)
dnj-1 37
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 37
  • 24 (a)
OneToMany
HLJ1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57340 36
  • 46.69 (n)
  • 37.31 (a)
rice
(Oryza sativa)
Liliopsida Os01g0556400 36
  • 50.87 (n)
  • 40.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for DNAJB12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB12 Gene

ENSEMBL:
Gene Tree for DNAJB12 (if available)
TreeFam:
Gene Tree for DNAJB12 (if available)

Paralogs for DNAJB12 Gene

Paralogs for DNAJB12 Gene

Pseudogenes.org Pseudogenes for DNAJB12 Gene

genes like me logo Genes that share paralogs with DNAJB12: view

Variants for DNAJB12 Gene

Sequence variations from dbSNP and Humsavar for DNAJB12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs870594 -- 72,335,210(-) GGTGG(C/T)GGCAG utr-variant-3-prime, intron-variant
rs1062747 -- 72,334,877(-) AGGTT(A/C)TTCTC utr-variant-3-prime, intron-variant
rs1879470 -- 72,353,099(+) AGGTG(A/G)TTCTT intron-variant
rs1879471 -- 72,334,907(+) TTCTC(C/T)GGGCT utr-variant-3-prime, intron-variant
rs3183629 -- 72,334,176(-) atgcg(C/T)gtata utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DNAJB12 Gene

Variant ID Type Subtype PubMed ID
nsv895721 CNV Gain 21882294

Relevant External Links for DNAJB12 Gene

HapMap Linkage Disequilibrium report
DNAJB12

Disorders for DNAJB12 Gene

(1) MalaCards Diseases for DNAJB12 Gene

Search for DNAJB12 Gene in MalaCards »

(3) University of Copenhagen DISEASES for DNAJB12 Gene

genes like me logo Genes that share disorders with DNAJB12: view

No data available for UniProtKB/Swiss-Prot for DNAJB12 Gene

Publications for DNAJB12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for DNAJB12 Gene

Sources for DNAJB12 Gene

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