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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB11 Gene

protein-coding   GIFtS: 56
GCID: GC03P186285

DnaJ (Hsp40) Homolog, Subfamily B, Member 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 111 2     DJ92
DnaJ Protein Homolog 92 3     Dj-92
ER-Associated DnaJ Protein 32 3     ERj32
Human DnaJ Protein 92 3     PRO10802
ABBP-22 3     UNQ5372
EDJ2 3     DnaJ Homolog Subfamily B Member 112
ERdj32 3     DnaJ Protein 92
ERj3p2 3     Endoplasmic Reticulum DNA J Domain-Containing Protein 32
APOBEC1-Binding Protein 22 3     ER-Resident Protein ERdj32
ER-Associated Hsp40 Co-Chaperone2 3     ERJ33
hDj-92 3     HDJ93
PWP1-Interacting Protein 42 3     HEDJ3
ABBP22     ER-Associated DNAJ3

External Ids:    HGNC: 148891   Entrez Gene: 517262   Ensembl: ENSG000000905207   OMIM: 6113415   UniProtKB: Q9UBS43   

Export aliases for DNAJB11 gene to outside databases

Previous GC identifers: GC03P183060 GC03P187545 GC03P187687 GC03P187606 GC03P187609 GC03P187767 GC03P183697


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJB11 Gene:
DNAJB11 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone
activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino
acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a C-terminal
cysteine-rich region (Ohtsuka and Hata, 2000 (PubMed 11147971)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAJB11 Gene: 
DNAJB11 (DnaJ (Hsp40) homolog, subfamily B, member 11) is a protein-coding gene. Diseases associated with DNAJB11 include enamel caries, and dentin caries, and among its related super-pathways are Activation of Chaperones by IRE1alpha and Post-translational protein modification. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA2.

UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4
Function: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for
ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding
is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity

Gene Wiki entry for DNAJB11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB11 gene promoter:
         AhR   RP58   CBF-C   Arnt   Evi-1   CBF-A   POU2F1   CBF-B   POU2F1a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB11 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

DNAJB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186285:  view genomic region     (about GC identifiers)

Start:
186,285,192 bp from pter      End:
186,315,061 bp from pter
Size:
29,870 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 11 precursor  
Size: 358 amino acids; 40514 Da
Subunit: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4,
PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds
to denatured substrates in an ATP-independent manner. Interacts via the J domain with HSPA5 in an ATP-dependent
manner
Subcellular location: Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally
epitope-tagged construct
Caution: PubMed:11584023 reported a cytosolic, as well as nuclear subcellular location. This result was obtained
using an N-terminally GFP-tagged construct which most probably affected signal peptide-driven targeting to the
ER. As a consequence, the in vivo revelance of the observed interaction with APOBEC1, a nuclear protein, is
dubious. This holds true for the interaction with PWP1
Secondary accessions: Q542Y5 Q542Y9 Q6IAQ8 Q96JC6

Explore the universe of human proteins at neXtProt for DNAJB11: NX_Q9UBS4

Explore proteomics data for DNAJB11 at MOPED 

Post-translational modifications:

  • UniProtKB: Contains high-mannose Endo H-sensitive carbohydrates
  • UniProtKB: Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys
    is not known
  • UniProtKB: Thr-188 was reported (PubMed:17525332) to be phosphorylated upon DNA damage by ATM or ATR; however as this
    position has been shown to be in the ER lumen, the in vivo relevance is not proven
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBS4

  • DNAJB11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJB11 Protein Expression
    REFSEQ proteins: NP_057390.1  
    ENSEMBL proteins: 
     ENSP00000414398   ENSP00000408410   ENSP00000265028   ENSP00000440189  
    Reactome Protein details: Q9UBS4
    Human Recombinant Protein Products for DNAJB11: 
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    Novus Biologicals DNAJB11 Proteins
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DNAJB11
    Cloud-Clone Corp. Proteins for DNAJB11 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--

    DNAJB11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q9UBS4

    ProtoNet protein and cluster: Q9UBS4

    UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4
    Similarity: Contains 1 J domain


    DNAJB11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJB11_HUMAN, Q9UBS4
    Function: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for
    ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding
    is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity
    Induction: By endoplasmic reticulum stress-inducing agents such as thapsigargin and tunicamycin

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051082unfolded protein binding IEA--
         
    DNAJB11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJB11 
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    miRNA
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    miRTarBase miRNAs that target DNAJB11:
    hsa-mir-29b (MIRT002316)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAJB11
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB11 (see all 17):
    hsa-miR-4254 hsa-miR-448 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-605 hsa-miR-548x hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB11 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNAJB11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for DNAJB11
        Activation of Chaperone Genes by XBP1(S)
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response


    1         Kegg Pathway  (Kegg details for DNAJB11):
        Protein processing in endoplasmic reticulum


    DNAJB11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJB11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for DNAJB11 (Q9UBS42, 3 ENSP000002650284) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0016556mRNA modification IEA--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    DNAJB11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB11 (DJB11)

    Search CenterWatch for drugs/clinical trials and news about DNAJB11 / DJB11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB11 gene: 
    NM_016306.4  

    Unigene Cluster for DNAJB11:

    DnaJ (Hsp40) homolog, subfamily B, member 11
    Hs.317192  [show with all ESTs]
    Unigene Representative Sequence: BC046500
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439351(uc003fqi.3) ENST00000464877 ENST00000495390 ENST00000418776
    ENST00000265028 ENST00000538831
    miRNA
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    hsa-miR-4254 hsa-miR-448 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-605 hsa-miR-548x hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB11 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB11

    Additional mRNA sequence: 

    AB028859.2 AF228505.1 AF277317.1 AJ250137.1 AK075300.1 AK075430.1 AK301292.1 AY359043.1 
    BC001144.1 BC046500.1 BT007063.1 CR457096.1 

    11 DOTS entries:

    DT.100814939  DT.447043  DT.100654343  DT.40211504  DT.100734534  DT.120900608  DT.120900646  DT.92440848 
    DT.95220626  DT.100723996  DT.75144958 

    24/291 AceView cDNA sequences (see all 291):

    AA323118 AF228505 AA912734 BQ011334 CR599807 CR613565 BM904217 BQ013184 
    BU680029 CB851056 AK124289 BU742452 CR610081 BM971107 BU608990 AJ250137 
    BM754506 BE384962 AA654238 AA977292 CR623667 CR622358 AA323066 BQ448342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTACCCCT
    DNAJB11 Expression
    About this image


    See DNAJB11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB11

    SOURCE GeneReport for Unigene cluster: Hs.317192

    UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJB11: 
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              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB11 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb111 , 5 DnaJ (Hsp40) homolog, subfamily B, member 111, 5 90.78(n)1
    98.32(a)1
      16 (13.71 cM)5
    678381  NM_001190804.11  NP_001177733.11 
     228578455 
    chicken
    (Gallus gallus)
    Aves DNAJB111 DnaJ (Hsp40) homolog, subfamily B, member 11 78.96(n)
    91.9(a)
      424868  XM_422682.3  XP_422682.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB116
    DnaJ (Hsp40) homolog, subfamily B, member 11
    93(a)
    1 ↔ 1
    3(33600771-33613311)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.51802 Xenopus laevis transcribed sequence with strong similarity more 78.03(n)    CA982552.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajb112 DnaJ (Hsp40) homolog, subfamily B, member 11 77.37(n)   386709  BC044559.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG41641 , 3 heat shock protein3
    CG41641
    63(a)3
    59.75(n)1
    64.33(a)1
      21C63
    332201  NM_134681.21  NP_608525.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-201 Protein DNJ-20 59.37(n)
    60.06(a)
      174514  NM_171030.3  NP_741036.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDJ16
    Type I HSP40 co-chaperone involved in regulation o...
    30(a)
    1 → many
    XIV(505868-507097)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATERDJ3B1 DNAJ heat shock family protein 54.54(n)
    50.15(a)
      825434  NM_116125.2  NP_191819.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01565001 hypothetical protein 54.17(n)
    51.39(a)
      4337860  NM_001061232.1  NP_001054697.1 


    ENSEMBL Gene Tree for DNAJB11 (if available)
    TreeFam Gene Tree for DNAJB11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB11 gene
    DNAJA22  DNAJA12  DNAJA42  
    7 SIMAP similar genes for DNAJB11 using alignment to 3 protein entries:     DJB11_HUMAN (see all proteins):
    PET100    DNAJA2    DNAJB1    DNAJB13    DNAJB4    DNAJB5
    DNAJA1

    DNAJB11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/314 SNPs in DNAJB11 are shown (see all 314)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399399681,2
    --186290398(+) TCGTTC/TAATCA 1 -- int10--------
    rs1433589591,2
    --186290475(+) TGAACC/TAGACA 1 -- int10--------
    rs1436715141,2
    C--186290699(+) CTAGA-/TTTTTT 1 -- int10--------
    rs1468641041,2
    C--186290774(+) CAAAC-/AGAGCAC 1 -- int10--------
    rs117093191,2
    C,H--186290810(+) CTAATA/CTGGGG 1 -- int10--------
    rs1853538011,2
    --186290965(+) CCTGAA/GTTTAA 1 -- int10--------
    rs1888865361,2
    --186291007(+) AACAAA/GTTGAA 1 -- int10--------
    rs1819803641,2
    --186291144(+) TTTCAA/GCACCT 1 -- int10--------
    rs730594161,2
    C,F--186291148(+) AACACC/ATTCAG 1 -- int12Minor allele frequency- A:0.08WA 120
    rs1862448831,2
    --186291230(+) GTAGAA/GTGGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNAJB11 (186285192 - 186315061 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJB11: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB11
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611341    OMIM disorders: --

    8 diseases for DNAJB11:    About MalaCards
    enamel caries    dentin caries    dentinogenesis imperfecta    bullous pemphigoid
    tuberculosis    endotheliitis    pancreatitis    breast cancer


    DNAJB11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNAJB11
    Human Genome Epidemiology (HuGE) Navigator: DNAJB11 (3 documents)

    Export disorders for DNAJB11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB11 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with DNAJB11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. (PubMed id 10827079)1, 2, 3, 9 Yu M.... Haslam D.B. (2000)
    2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 2, 3 Ohtsuka K. and Hata M. (2000)
    3. Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. (PubMed id 15544163)1, 2, 9 Nakanishi K....Sato N. (2004)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Contribution of the HEDJ/ERdj3 cysteine-rich domain to substrate interactions. (PubMed id 17976514)1, 2 Marcus N.Y.... Haslam D.B. (2007)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    7. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. (PubMed id 15525676)1, 2 Shen Y. and Hendershot L.M. (2005)
    8. Characterization of pancreatic ERj3p, a homolog of yeast DnaJ-like protein Scj1p. (PubMed id 15195998)1, 2 Bies C....Zimmermann R. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51726 HGNC: 14889 AceView: DNAJB11 Ensembl:ENSG00000090520 euGenes: HUgn51726
    ECgene: DNAJB11 Kegg: 51726 H-InvDB: DNAJB11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJB11 gene:
    Search GeneIP for patents involving DNAJB11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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