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DNAJB11 Gene

protein-coding   GIFtS: 57
GCID: GC03P186285

DnaJ (Hsp40) Homolog, Subfamily B, Member 11

  Search for DNAJB11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 111 2     Dj-92
Endoplasmic Reticulum DNA J Domain-Containing Protein 32 3     ERj32
ABBP-22 3     PRO10802
EDJ2 3     UNQ5372
ERdj32 3     DnaJ Homolog Subfamily B Member 112
ERj3p2 3     DnaJ Protein 92
APOBEC1-Binding Protein 22 3     ER-Associated DNAJ Protein 32
ER-Associated Hsp40 Co-Chaperone2 3     ERJ33
ER-Resident Protein ERdj32 3     HDJ93
PWP1-Interacting Protein 42 3     DnaJ Protein Homolog 93
ABBP22 5     ER-Associated DNAJ3
DJ92 5     hDj-93
HEDJ3 5     Human DnaJ Protein 93

External Ids:    HGNC: 148891   Entrez Gene: 517262   Ensembl: ENSG000000905207   OMIM: 6113415   UniProtKB: Q9UBS43   

Export aliases for DNAJB11 gene to outside databases

Previous GC identifers: GC03P183060 GC03P187545 GC03P187687 GC03P187606 GC03P187609 GC03P187767 GC03P183697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJB11 Gene:
This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone
of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding
and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino
acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin
protein by stimulating ATPase activity. (provided by RefSeq, Mar 2014)

GeneCards Summary for DNAJB11 Gene:
DNAJB11 (DnaJ (Hsp40) homolog, subfamily B, member 11) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJA2.

UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4
Function: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for
ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding
is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity

Gene Wiki entry for DNAJB11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJB11 gene promoter:
         AhR   RP58   CBF-C   Arnt   Evi-1   CBF-A   POU2F1   CBF-B   POU2F1a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB11 promoter sequence
   Search Chromatin IP Primers for DNAJB11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

DNAJB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186285:  view genomic region     (about GC identifiers)

Start:
186,285,192 bp from pter      End:
186,315,061 bp from pter
Size:
29,870 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 11 precursor  
Size: 358 amino acids; 40514 Da
Subunit: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4,
PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds
to denatured substrates in an ATP-independent manner. Interacts via the J domain with HSPA5 in an ATP-dependent
manner
Caution: PubMed:11584023 reported a cytosolic, as well as nuclear subcellular location. This result was obtained
using an N-terminally GFP-tagged construct which most probably affected signal peptide-driven targeting to the
ER. As a consequence, the in vivo revelance of the observed interaction with APOBEC1, a nuclear protein, is
dubious. This holds true for the interaction with PWP1
Secondary accessions: Q542Y5 Q542Y9 Q6IAQ8 Q96JC6

Explore the universe of human proteins at neXtProt for DNAJB11: NX_Q9UBS4

Explore proteomics data for DNAJB11 at MOPED

Post-translational modifications: 

  • Contains high-mannose Endo H-sensitive carbohydrates1
  • Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys
    is not known1
  • Thr-188 was reported (PubMed:17525332) to be phosphorylated upon DNA damage by ATM or ATR; however as this
    position has been shown to be in the ER lumen, the in vivo relevance is not proven1
  • Ubiquitination2 at Lys28
  • Glycosylation2 at Asn261
  • Modification sites at PhosphoSitePlus

  • See DNAJB11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057390.1  
    ENSEMBL proteins: 
     ENSP00000414398   ENSP00000408410   ENSP00000265028   ENSP00000440189  
    Reactome Protein details: Q9UBS4

    DNAJB11 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q9UBS4

    ProtoNet protein and cluster: Q9UBS4

    UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJB11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJB11_HUMAN, Q9UBS4
    Function: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for
    ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding
    is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity
    Induction: By endoplasmic reticulum stress-inducing agents such as thapsigargin and tunicamycin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18923428
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with DNAJB11           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJB11
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    miRNA
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    miRTarBase miRNAs that target DNAJB11:
    hsa-mir-181b-5p (MIRT047230), hsa-mir-29b-3p (MIRT002316)

    Block miRNA regulation of human, mouse, rat DNAJB11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB11 (see all 17):
    hsa-miR-4254 hsa-miR-448 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-605 hsa-miR-548x hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DJB11_HUMAN, Q9UBS4: Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally
    epitope-tagged construct
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with DNAJB11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJB11 About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with DNAJB11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DNAJB11
        XBP1(S) activates chaperone genes


    1 Kegg Pathway  (Kegg details for DNAJB11):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB11: 
              Hepatotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJB11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJB11 (Q9UBS41, 2, 3 ENSP000002650284) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0016556mRNA modification IEA--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with DNAJB11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DNAJB11 (DJB11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJB11 gene: 
    NM_016306.5  

    Unigene Cluster for DNAJB11:

    DnaJ (Hsp40) homolog, subfamily B, member 11
    Hs.317192  [show with all ESTs]
    Unigene Representative Sequence: BC046500
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439351(uc003fqi.3) ENST00000464877 ENST00000495390 ENST00000418776
    ENST00000265028 ENST00000538831
    miRNA
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    Block miRNA regulation of human, mouse, rat DNAJB11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB11 (see all 17):
    hsa-miR-4254 hsa-miR-448 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-605 hsa-miR-548x hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB11 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DNAJB11
      QuantiFast Probe-based Assays in human, mouse, rat DNAJB11

    Additional mRNA sequence: 

    AB028859.2 AF228505.1 AF277317.1 AJ250137.1 AK075300.1 AK075430.1 AK301292.1 AY359043.1 
    BC001144.1 BC046500.1 BT007063.1 CR457096.1 

    11 DOTS entries:

    DT.100814939  DT.447043  DT.100654343  DT.40211504  DT.100734534  DT.120900608  DT.120900646  DT.92440848 
    DT.95220626  DT.100723996  DT.75144958 

    Selected AceView cDNA sequences (see all 291):

    AA977292 BM847412 CR595918 AB028859 AF228505 BU680029 CR622358 CR609150 
    BE384962 BQ011334 AI925011 AI207282 AA323118 BM311207 CD364478 AA323066 
    C02695 CR623667 BM792504 CB851056 BM754506 BC046500 CD742799 BU616366 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJB11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTACCCCT
    DNAJB11 Expression
    About this image


    DNAJB11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Ovary (Reproductive System)
             Oviduct
    DNAJB11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJB11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.317192

    UniProtKB/Swiss-Prot: DJB11_HUMAN, Q9UBS4
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB11: 
              Hepatotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB11 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb111 , 5 DnaJ (Hsp40) homolog, subfamily B, member 111, 5 90.78(n)1
    98.32(a)1
      16 (13.71 cM)5
    678381  NM_001190804.11  NP_001177733.11 
     228578455 
    chicken
    (Gallus gallus)
    Aves DNAJB111 DnaJ (Hsp40) homolog, subfamily B, member 11 78.96(n)
    91.9(a)
      424868  XM_422682.4  XP_422682.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB116
    DnaJ (Hsp40) homolog, subfamily B, member 11
    93(a)
    1 ↔ 1
    3(33600771-33613311)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.51802 Xenopus laevis transcribed sequence with strong similarity more 78.03(n)    CA982552.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajb112 DnaJ (Hsp40) homolog, subfamily B, member 11 77.37(n)   386709  BC044559.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG41641 , 3 heat shock protein3
    CG41641
    63(a)3
    59.98(n)1
    64.24(a)1
      21C63
    332201  NM_134681.31  NP_608525.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-201 dnj-20 59.07(n)
    58.88(a)
      174514  NM_171030.4  NP_741036.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDJ16
    Type I HSP40 co-chaperone involved in regulation o...
    30(a)
    1 → many
    XIV(505868-507097) YNL064C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATERDJ3B1 ATERDJ3B 54.41(n)
    49.54(a)
      825434  NM_116125.2  NP_191819.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01565001 Os05g0156500 54.17(n)
    51.39(a)
      4337860  NM_001061232.1  NP_001054697.1 


    ENSEMBL Gene Tree for DNAJB11 (if available)
    TreeFam Gene Tree for DNAJB11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJB11 gene
    DNAJA22  DNAJA12  DNAJA42  
    7 SIMAP similar genes for DNAJB11 using alignment to 3 protein entries:     DJB11_HUMAN (see all proteins):
    PET100    DNAJA2    DNAJB1    DNAJB13    DNAJB4    DNAJB5
    DNAJA1

    Find genes that share paralogs with DNAJB11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJB11 (see all 314)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399399681,2
    --186290398(+) TCGTTC/TAATCA 1 -- int10--------
    rs1433589591,2
    --186290475(+) TGAACC/TAGACA 1 -- int10--------
    rs1436715141,2
    C--186290699(+) CTAGA-/TTTTTT 1 -- int10--------
    rs1468641041,2
    C--186290774(+) CAAAC-/AGAGCAC 1 -- int10--------
    rs117093191,2
    C,H--186290810(+) CTAATA/CTGGGG 1 -- int10--------
    rs1853538011,2
    --186290965(+) CCTGAA/GTTTAA 1 -- int10--------
    rs1888865361,2
    --186291007(+) AACAAA/GTTGAA 1 -- int10--------
    rs1819803641,2
    --186291144(+) TTTCAA/GCACCT 1 -- int10--------
    rs730594161,2
    C,F--186291148(+) AACACC/ATTCAG 1 -- int12Minor allele frequency- A:0.08WA 120
    rs1862448831,2
    --186291230(+) GTAGAA/GTGGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNAJB11 (186285192 - 186315061 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJB11: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB11
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611341    OMIM disorders: --


    Find genes that share disorders with DNAJB11           About GenesLikeMe

    Genetic Association Database (GAD): DNAJB11
    Human Genome Epidemiology (HuGE) Navigator: DNAJB11 (3 documents)

    Export disorders for DNAJB11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJB11 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with DNAJB11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. (PubMed id 10827079)1, 2, 3, 9 Yu M.... Haslam D.B. (J. Biol. Chem. 2000)
    2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 2, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    3. Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. (PubMed id 15544163)1, 2, 9 Nakanishi K.... Sato N. (Cell Stress Chaperones 2004)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Contribution of the HEDJ/ERdj3 cysteine-rich domain to substrate interactions. (PubMed id 17976514)1, 2 Marcus N.Y.... Haslam D.B. (Arch. Biochem. Biophys. 2007)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    7. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. (PubMed id 15525676)1, 2 Shen Y. and Hendershot L.M. (Mol. Biol. Cell 2005)
    8. Characterization of pancreatic ERj3p, a homolog of yeast DnaJ-like protein Scj1p. (PubMed id 15195998)1, 2 Bies C....Zimmermann R. (Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51726 HGNC: 14889 AceView: DNAJB11 Ensembl:ENSG00000090520 euGenes: HUgn51726
    ECgene: DNAJB11 Kegg: 51726 H-InvDB: DNAJB11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJB11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJB11 gene:
    Search GeneIP for patents involving DNAJB11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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