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Aliases for DNAJB1 Gene

Aliases for DNAJB1 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B1 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 1 2 3
  • Heat Shock 40 KDa Protein 1 3 4
  • DnaJ Protein Homolog 1 3 4
  • Human DnaJ Protein 1 3 4
  • Hsp40 3 4
  • HSPF1 3 4
  • Hdj1 3 4
  • Radial Spoke 16 Homolog B (Chlamydomonas) 2
  • DnaJ Homolog Subfamily B Member 1 3
  • Radial Spoke 16 Homolog B 3
  • Heat Shock Protein 40 4
  • RSPH16B 3
  • DNAJ1 4
  • HDj-1 4
  • Sis1 3

External Ids for DNAJB1 Gene

Previous HGNC Symbols for DNAJB1 Gene

  • HSPF1

Previous GeneCards Identifiers for DNAJB1 Gene

  • GC19M014980
  • GC19M014470
  • GC19M014625
  • GC19M014195

Summaries for DNAJB1 Gene

Entrez Gene Summary for DNAJB1 Gene

  • This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for DNAJB1 Gene

DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) is a Protein Coding gene. Diseases associated with DNAJB1 include Hepatocellular Fibrolamellar Carcinoma and Sleeping Sickness. Among its related pathways are Cellular Senescence and Signaling by GPCR. GO annotations related to this gene include unfolded protein binding and ATPase binding. An important paralog of this gene is DNAJB4.

UniProtKB/Swiss-Prot for DNAJB1 Gene

  • Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.

Gene Wiki entry for DNAJB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB1 Gene

Genomics for DNAJB1 Gene

Regulatory Elements for DNAJB1 Gene

Enhancers for DNAJB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DNAJB1 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DNAJB1 Gene

14,514,764 bp from pter
14,529,770 bp from pter
15,007 bases
Minus strand

Genomic View for DNAJB1 Gene

Genes around DNAJB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB1 Gene

Proteins for DNAJB1 Gene

  • Protein details for DNAJB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 1
    Protein Accession:
    Secondary Accessions:
    • B4DX52

    Protein attributes for DNAJB1 Gene

    340 amino acids
    Molecular mass:
    38044 Da
    Quaternary structure:
    • Interacts with DNAJC3. Interacts with SRPK1.
    • Sequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJB1 Gene

    Alternative splice isoforms for DNAJB1 Gene


neXtProt entry for DNAJB1 Gene

Post-translational modifications for DNAJB1 Gene

  • Ubiquitination at Lys 3 and Lys 286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJB1 Gene

Domains & Families for DNAJB1 Gene

Gene Families for DNAJB1 Gene

Protein Domains for DNAJB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB1: view

Function for DNAJB1 Gene

Molecular function for DNAJB1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity TAS --
GO:0005515 protein binding IPI 17024176
GO:0030544 Hsp70 protein binding IPI 23921388
GO:0051082 unfolded protein binding IDA 21231916
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB1: view
genes like me logo Genes that share phenotypes with DNAJB1: view

Animal Models for DNAJB1 Gene

MGI Knock Outs for DNAJB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJB1 Gene

Localization for DNAJB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.

Subcellular locations from

Jensen Localization Image for DNAJB1 Gene COMPARTMENTS Subcellular localization image for DNAJB1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 2
mitochondrion 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 25468996
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DNAJB1: view

Pathways & Interactions for DNAJB1 Gene

genes like me logo Genes that share pathways with DNAJB1: view

Pathways by source for DNAJB1 Gene

SIGNOR curated interactions for DNAJB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 8975727
GO:0032781 positive regulation of ATPase activity IDA 23921388
GO:0051085 chaperone mediated protein folding requiring cofactor IEA --
GO:0070389 chaperone cofactor-dependent protein refolding IDA 18620420
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJB1: view

Drugs & Compounds for DNAJB1 Gene

(2) Drugs for DNAJB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DNAJB1: view

Transcripts for DNAJB1 Gene

Unigene Clusters for DNAJB1 Gene

DnaJ (Hsp40) homolog, subfamily B, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB1 Gene

No ASD Table

Relevant External Links for DNAJB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB1 Gene

mRNA expression in normal human tissues for DNAJB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB1 Gene

This gene is overexpressed in Whole Blood (x5.3), Brain - Cerebellum (x4.6), and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for DNAJB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB1 Gene

Protein tissue co-expression partners for DNAJB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJB1 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB1 Gene:

genes like me logo Genes that share expression patterns with DNAJB1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DNAJB1 Gene

Orthologs for DNAJB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJB1 34
  • 93.53 (n)
  • 97.94 (a)
-- 35
  • 80 (a)
  • 98 (a)
(Canis familiaris)
Mammalia DNAJB1 34
  • 93.92 (n)
  • 97.65 (a)
  • 98 (a)
(Mus musculus)
Mammalia Dnajb1 34
  • 90.59 (n)
  • 95.59 (a)
Dnajb1 16
Dnajb1 35
  • 96 (a)
(Pan troglodytes)
Mammalia DNAJB1 34
  • 98.92 (n)
  • 99.12 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajb1 34
  • 92.06 (n)
  • 96.75 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJB1 35
  • 84 (a)
(Gallus gallus)
Aves LOC100858808 34
  • 71.08 (n)
  • 78.31 (a)
(Anolis carolinensis)
Reptilia DNAJB1 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb1 34
  • 67.26 (n)
  • 71.64 (a)
(Danio rerio)
Actinopterygii dnajb1a 34
  • 65.46 (n)
  • 68.98 (a)
wufd19c10 34
dnajb1a 35
  • 69 (a)
dnajb1b 35
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2887 36
  • 38 (a)
CG5001 36
  • 48 (a)
DnaJ-1 36
  • 52 (a)
CG2887 35
  • 42 (a)
CG5001 35
  • 49 (a)
DnaJ-1 35
  • 51 (a)
(Caenorhabditis elegans)
Secernentea dnj-13 35
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL008W 34
  • 48.89 (n)
  • 42.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04818g 34
  • 47.44 (n)
  • 41.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 34
  • 46.31 (n)
  • 40.51 (a)
(Oryza sativa)
Liliopsida Os01g0239100 34
  • 54.43 (n)
  • 48.06 (a)
(Triticum aestivum)
Liliopsida Ta.9199 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03732 34
  • 49.39 (n)
  • 40.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes psi1 34
  • 51.14 (n)
  • 46.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
Species where no ortholog for DNAJB1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB1 Gene

Gene Tree for DNAJB1 (if available)
Gene Tree for DNAJB1 (if available)

Paralogs for DNAJB1 Gene Pseudogenes for DNAJB1 Gene

genes like me logo Genes that share paralogs with DNAJB1: view

Variants for DNAJB1 Gene

Sequence variations from dbSNP and Humsavar for DNAJB1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3962158 -- 14,518,338(-) AAAGA(C/T)TACTA intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs11085895 -- 14,518,738(+) CAGTA(A/G)GTCGG intron-variant, upstream-variant-2KB
rs28384438 -- 14,518,639(-) GGCCT(C/G)CTCCG intron-variant, upstream-variant-2KB
rs11540698 -- 14,515,618(-) AGATG(G/T)ACTTG utr-variant-3-prime
rs11540700 -- 14,518,327(-) CCAGA(C/G)GTTGG intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNAJB1 Gene

Variant ID Type Subtype PubMed ID
nsv961185 CNV duplication 23825009

Variation tolerance for DNAJB1 Gene

Residual Variation Intolerance Score: 8.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB1 Gene

Disorders for DNAJB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAJB1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular fibrolamellar carcinoma
  • fibrolamellar hepatocellular carcinoma
sleeping sickness
  • african sleeping sickness
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB1 Gene

Publications for DNAJB1 Gene

  1. Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2. (PMID: 8975727) Hata M. … Ohtsuka K. (Genomics 1996) 2 3 4 22 65
  2. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PMID: 9920933) Melville M.W. … Katze M.G. (J. Biol. Chem. 1999) 3 4 22 65
  3. Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ. (PMID: 8250930) Ohtsuka K. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 65
  4. Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. (PMID: 20026329) Yamamoto S. … Itoh H. (FEBS Lett. 2010) 3 22 65
  5. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PMID: 19254810) Hawkins G.A. … Bleecker E.R. (J. Allergy Clin. Immunol. 2009) 3 46 65

Products for DNAJB1 Gene

Sources for DNAJB1 Gene

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