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DNAJB1 Gene

protein-coding   GIFtS: 66
GCID: GC19M014625

DnaJ (Hsp40) Homolog, Subfamily B, Member 1


(Previous symbol: HSPF1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 11 2     RSPH16B2
HSPF11 2 3 5     Sis12
DnaJ Protein Homolog 12 3     DnaJ (Hsp40) Homolog, Subfmaily B, Member 12
Heat Shock 40 KDa Protein 12 3     DnaJ Homolog Subfamily B Member 12
Heat Shock Protein 402 3     Heat Shock 40kD Protein 12
Human DnaJ Protein 12 3     Radial Spoke 16 Homolog B2
hDj-12 3     DNAJ13
Radial Spoke 16 Homolog B (Chlamydomonas)1     HDJ13
Hdj12     HSP403
Hsp402     

External Ids:    HGNC: 52701   Entrez Gene: 33372   Ensembl: ENSG000001320027   OMIM: 6045725   UniProtKB: P256853   

Export aliases for DNAJB1 gene to outside databases

Previous GC identifers: GC19M014980 GC19M014470 GC19M014486 GC19M014195


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJB1 Gene:
DNAJB1 (DnaJ (Hsp40) homolog, subfamily B, member 1) is a protein-coding gene. Diseases associated with DNAJB1 include sleeping sickness, and mucolipidosis. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJB4.

UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685
Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and
HIP

Gene Wiki entry for DNAJB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJB1 gene promoter:
         NF-1/L   NF-1   p53   MEF-2   LCR-F1   AP-2gamma   MEF-2A   ZID   aMEF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB1 promoter sequence
   Search Chromatin IP Primers for DNAJB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.2

DNAJB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014625:  view genomic region     (about GC identifiers)

Start:
14,625,582 bp from pter      End:
14,640,582 bp from pter
Size:
15,001 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 1  
Size: 340 amino acids; 38044 Da
Subunit: Interacts with DNAJC3. Interacts with SRPK1
Sequence caution: Sequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136;
5 PDB 3D structures from and Proteopedia for DNAJB1:
1HDJ (3D)        2QLD (3D)        3AGX (3D)        3AGY (3D)        3AGZ (3D)    

Explore the universe of human proteins at neXtProt for DNAJB1: NX_P25685

Explore proteomics data for DNAJB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys3, Lys286
  • Modification sites at PhosphoSitePlus

  • See DNAJB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006136.1  
    ENSEMBL proteins: 
     ENSP00000254322   ENSP00000444212   ENSP00000471073   ENSP00000469221   ENSP00000470063  
     ENSP00000470596   ENSP00000470460   ENSP00000471798   ENSP00000472886   ENSP00000471603  
    Reactome Protein details: P25685

    DNAJB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DNAJB1 (HSP40/DNAJB1)
    Enzo Life Sciences proteins for DNAJB1
    OriGene Purified Protein for DNAJB1
    OriGene Protein Over-expression Lysate for DNAJB1
    OriGene MassSpec for DNAJB1
    OriGene Custom Protein Services for DNAJB1
    GenScript Custom Purified and Recombinant Proteins Services for DNAJB1
    Novus Biologicals DNAJB1 Proteins
    Novus Biologicals DNAJB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DNAJB1
    Browse Proteins at Cloud-Clone Corp.

    DNAJB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DNAJB1
    R&D Systems Antibodies for DNAJB1 (HSP40/DNAJB1)
    Cell Signaling Technology (CST) Antibodies for DNAJB1 
    OriGene Antibodies for DNAJB1
    OriGene Custom Antibody Services for DNAJB1
    Novus Biologicals DNAJB1 Antibodies
    Abcam antibodies for DNAJB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for DNAJB1
    LSBio Antibodies in human, mouse, rat for DNAJB1

    DNAJB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNAJB1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for DNAJB1 (HSP40/DNAJB1)
    GenScript Custom Assay Services for DNAJB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry P25685

    ProtoNet protein and cluster: P25685

    UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685
    Similarity: Contains 1 J domain


    DNAJB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJB1_HUMAN, P25685
    Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and
    HIP
    Induction: By heat shock

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17024176
    GO:0051082unfolded protein binding IEA--
         
    DNAJB1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DNAJB1:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dnajb1):
     normal 

    DNAJB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnajb1tm1Kate for DNAJB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJB1:
    hsa-mir-10a-5p (MIRT047590), hsa-mir-30a-5p (MIRT028591), hsa-mir-122-5p (MIRT023313), hsa-mir-155-5p (MIRT001553), hsa-mir-16-5p (MIRT031754), hsa-mir-1 (MIRT001371)

    Block miRNA regulation of human, mouse, rat DNAJB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB1 (see all 52):
    hsa-miR-4291 hsa-miR-188-5p hsa-miR-1260b hsa-miR-488 hsa-miR-449a hsa-miR-500a hsa-miR-508-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJB1
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAJB1

    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJB1 (see all 7)
    OriGene ORF clones in mouse, rat for DNAJB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJB1 (NM_006145)
    Sino Biological Human cDNA Clone for DNAJB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DNAJB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJB1_HUMAN, P25685: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the
    nucleus, and especially to the nucleoli, upon heat shock
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum2
    mitochondrion2
    cytoskeleton1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    DNAJB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Androgen Signaling
    Androgen Signaling0.52
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    3Influenza A
    Influenza A0.34
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DNAJB1
        Androgen Signaling

    1 GeneGo (Thomson Reuters) Pathway for DNAJB1
        CFTR folding and maturation (norm and CF)


    3 Reactome Pathways for DNAJB1
        Regulation of HSF1-mediated heat shock response
    HSF1-dependent transactivation
    Attenuation phase


    2 Kegg Pathways  (Kegg details for DNAJB1):
        Protein processing in endoplasmic reticulum
    Influenza A


    DNAJB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB1: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJB1 (P256851, 2, 3 ENSP000002543224) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234475P081073, ENSP000004089074I2D: score=2 STRING: ENSP00000408907
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ----
    GO:0006986response to unfolded protein TAS8975727
    GO:0051085chaperone mediated protein folding requiring cofactor IEA--
    GO:0070389chaperone cofactor-dependent protein refolding IDA18620420

    DNAJB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJB1 (DNJB1)

    2 Novoseek inferred chemical compound relationships for DNAJB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 38.9 13 8702658 (4), 9321400 (1), 9804845 (1), 9395086 (1) (see all 6)
    glutamine 28.6 4 10942430 (2), 20159555 (1)



    DNAJB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJB1 gene: 
    NM_006145.1  

    Unigene Cluster for DNAJB1:

    DnaJ (Hsp40) homolog, subfamily B, member 1
    Hs.515210  [show with all ESTs]
    Unigene Representative Sequence: BC002352
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254322(uc002myz.1 uc010xnr.1) ENST00000396969 ENST00000598235
    ENST00000595139 ENST00000596853 ENST00000595992 ENST00000594099 ENST00000601533
    ENST00000598692 ENST00000596075 ENST00000601087
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJB1 (see all 52):
    hsa-miR-4291 hsa-miR-188-5p hsa-miR-1260b hsa-miR-488 hsa-miR-449a hsa-miR-500a hsa-miR-508-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJB1
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJB1
    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJB1 (see all 7)
    OriGene ORF clones in mouse, rat for DNAJB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJB1 (NM_006145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAJB1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB1
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJB1
      QuantiFast Probe-based Assays in human, mouse, rat DNAJB1

    Additional mRNA sequence: 

    AK092989.1 AK296609.1 AK301817.1 AK312624.1 BC002352.2 BC013157.2 BC019827.1 CR536485.1 
    CR541677.1 D49547.1 X62421.1 

    Selected DOTS entries (see all 37):

    DT.95336008  DT.87018253  DT.92325314  DT.100880070  DT.100880076  DT.100880080  DT.95130729  DT.92470861 
    DT.92470857  DT.92470854  DT.97862657  DT.100880072  DT.100880063  DT.40290333  DT.100880085  DT.100880083 
    DT.121494561  DT.100038711  DT.100880078  DT.102843562  DT.121494423  DT.121494539  DT.87014573  DT.95336006 

    Selected AceView cDNA sequences (see all 797):

    BU557398 AA642497 BQ222712 AA346266 BQ879650 BG106134 CD742995 BG319530 
    BQ440259 CR602787 AW439697 AA028936 BU156793 CF127351 BQ214323 W70286 
    R27919 CR615749 BF447520 CB146771 BF476639 BM784027 CA307376 AU134346 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACCAAAGT
    DNAJB1 Expression
    About this image


    DNAJB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Globus Pallidus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    DNAJB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515210
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJB1: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJB1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJB1
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJB1
    QuantiFast Probe-based Assays in human, mouse, rat DNAJB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb11 , 5 DnaJ (Hsp40) homolog, subfamily B, member 11, 5 90.59(n)1
    95.59(a)1
      8 (40.22 cM)5
    814891  NM_018808.21  NP_061278.11 
     836081755 
    chicken
    (Gallus gallus)
    Aves LOC1008588081 dnaJ homolog subfamily B member 1-like 71.08(n)
    78.31(a)
      100858808  XM_003643562.2  XP_003643610.2 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB16
    DnaJ (Hsp40) homolog, subfamily B, member 1
    81(a)
    1 ↔ 1
    2(102671214-102680418)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 1 67.26(n)
    71.64(a)
      493474  NM_001008111.1  NP_001008112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd19c102 wufd19c10 74.4(n)   327244  BC045359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DnaJ-13 chaperone 52(a)
    (best of 3)
      64E5   --
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-136
    Protein DNJ-13 (dnj-13) mRNA, complete cds
    54(a)
    1 → many
    II(11545701-11547366) WBGene00001031
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIS11 SIS1 46.31(n)
    40.51(a)
      855725   NP_014391.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02391001 Os01g0239100 54.43(n)
    48.06(a)
      4326364  NM_001049078.1  NP_001042543.1 


    ENSEMBL Gene Tree for DNAJB1 (if available)
    TreeFam Gene Tree for DNAJB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for DNAJB1 gene
    DNAJB42  DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB72  DNAJC5B2  
    DNAJC52  DNAJC5G2  DNAJB82  
    12 SIMAP similar genes for DNAJB1 using alignment to 10 protein entries:     DNJB1_HUMAN (see all proteins):
    DNAJB4    DNAJB5    DNAJB13    DNAJB3    DNAJB8    MST104
    HDJ2    DNAJB9    DNAJA1    DNAJA2    DNAJB11    DNAJA4

    DNAJB1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DNAJB1
    PGOHUM00000240463 PGOHUM00000237725


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJB1 (see all 196)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130201631,2
    C,F--14625095(+) AGGCAG/AGAAAT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1450353331,2
    --14625129(+) GTCCTC/GGGCAG 1 -- ds50010--------
    rs104117381,2
    C,F,A,H--14625170(+) GGACGC/TCCAGC 1 -- ds500114Minor allele frequency- T:0.13NS EA NA CSA WA 792
    rs1483040941,2
    --14625297(+) AGGAGA/CCAGAC 1 -- ds50010--------
    rs1163391141,2
    C,F--14625325(+) CTACTT/CTGACT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1847328591,2
    --14625331(+) TGACTC/GCAACC 1 -- ds50010--------
    rs169797151,2
    C,F--14625348(+) AAAAAA/CTGATC 1 -- ds50014Minor allele frequency- C:0.02NA WA 258
    rs1404335741,2
    --14625396(+) CCCCGA/TGTCTG 1 -- ds50010--------
    rs104175051,2
    C,F,A,H--14625447(+) ACTTAC/TGTTTC 1 -- ds500115Minor allele frequency- T:0.17NA NS EA CSA WA 796
    rs1144210831,2
    F--14625504(+) TTGAAT/GTTGGA 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for DNAJB1 (14625582 - 14640582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DNAJB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911128CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB1
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604572    OMIM disorders: --

    Selected diseases for DNAJB1 (see all 21):    
    About MalaCards
    sleeping sickness    mucolipidosis    fanconi's anemia    bipolar disorder
    herpes simplex    influenza    huntington's disease    hepatitis b
    parkinson's disease    schizophrenia    hodgkin's lymphoma    tuberculosis
    alzheimer's disease    hypertension    hepatitis    hiv-1
    breast cancer    cerebritis    neuronitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for DNAJB1:
    Huntington's disease

    DNAJB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for DNAJB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 66.6 27 8975727 (2), 9546042 (1), 10330192 (1), 17239655 (1) (see all 16)
    neurodegenerative diseases 16.2 1 11044589 (1)
    tumors 3.9 2 15176219 (1), 10725457 (1)
    immunodeficiency 0 1 11932435 (1)

    Genetic Association Database (GAD): DNAJB1
    Human Genome Epidemiology (HuGE) Navigator: DNAJB1 (4 documents)

    Export disorders for DNAJB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJB1 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with DNAJB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2. (PubMed id 8975727)1, 2, 3, 9 Hata M.... Ohtsuka K. (Genomics 1996)
    2. Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ. (PubMed id 8250930)1, 2, 3 Ohtsuka K. (Biochem. Biophys. Res. Commun. 1993)
    3. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PubMed id 9920933)1, 2, 9 Melville M.W....Katze M.G. (J. Biol. Chem. 1999)
    4. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain. (PubMed id 8764402)1, 2 Qian Y.Q.... McColl D.J. (J. Mol. Biol. 1996)
    9. Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells. (PubMed id 1586970)1, 2 Hattori H.... Ohtsuka K. (Cell Struct. Funct. 1992)
    10. A human homologue of the Escherichia coli DnaJ heat-shock protein. (PubMed id 1754405)1, 2 Raabe T. and Manley J.L. (Nucleic Acids Res. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3337 HGNC: 5270 AceView: DNAJB1 Ensembl:ENSG00000132002 euGenes: HUgn3337
    ECgene: DNAJB1 Kegg: 3337 H-InvDB: DNAJB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJB1 gene:
    Search GeneIP for patents involving DNAJB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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