Aliases for DNAJB1 Gene
External Ids for DNAJB1 Gene
Previous HGNC Symbols for DNAJB1 Gene
Previous GeneCards Identifiers for DNAJB1 Gene
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for DNAJB1 Gene
DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) is a Protein Coding gene. Diseases associated with DNAJB1 include Hepatocellular Fibrolamellar Carcinoma. Among its related pathways are Cellular response to heat stress and HSF1-dependent transactivation. GO annotations related to this gene include unfolded protein binding and ATPase binding. An important paralog of this gene is DNAJB7.
UniProtKB/Swiss-Prot for DNAJB1 Gene
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.