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Aliases for DNAJB1 Gene

Aliases for DNAJB1 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 1 2 3
  • Heat Shock 40 KDa Protein 1 3 4
  • DnaJ Protein Homolog 1 3 4
  • Human DnaJ Protein 1 3 4
  • Hsp40 3 4
  • HSPF1 3 4
  • Hdj1 3 4
  • Radial Spoke 16 Homolog B (Chlamydomonas) 2
  • Radial Spoke 16 Homolog B 3
  • Heat Shock Protein 40 4
  • RSPH16B 3
  • DNAJ1 4
  • HDj-1 4
  • Sis1 3

External Ids for DNAJB1 Gene

Previous HGNC Symbols for DNAJB1 Gene

  • HSPF1

Previous GeneCards Identifiers for DNAJB1 Gene

  • GC19M014980
  • GC19M014470
  • GC19M014625
  • GC19M014195

Summaries for DNAJB1 Gene

Entrez Gene Summary for DNAJB1 Gene

  • This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for DNAJB1 Gene

DNAJB1 (DnaJ (Hsp40) Homolog, Subfamily B, Member 1) is a Protein Coding gene. Diseases associated with DNAJB1 include hepatocellular fibrolamellar carcinoma. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include unfolded protein binding and ATPase binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB1 Gene

  • Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP

Gene Wiki entry for DNAJB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB1 Gene

Genomics for DNAJB1 Gene

Regulatory Elements for DNAJB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJB1 Gene

14,514,764 bp from pter
14,529,770 bp from pter
15,007 bases
Minus strand

Genomic View for DNAJB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB1 Gene

Proteins for DNAJB1 Gene

  • Protein details for DNAJB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 1
    Protein Accession:
    Secondary Accessions:
    • B4DX52

    Protein attributes for DNAJB1 Gene

    340 amino acids
    Molecular mass:
    38044 Da
    Quaternary structure:
    • Interacts with DNAJC3. Interacts with SRPK1.
    • Sequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJB1 Gene

    Alternative splice isoforms for DNAJB1 Gene


neXtProt entry for DNAJB1 Gene

Proteomics data for DNAJB1 Gene at MOPED

Post-translational modifications for DNAJB1 Gene

  • Ubiquitination at Lys 3 and Lys 286
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for DNAJB1 (HSP40/DNAJB1)
  • Cell Signaling Technology (CST) Antibodies for DNAJB1 (HSP40)

No data available for DME Specific Peptides for DNAJB1 Gene

Domains & Families for DNAJB1 Gene

Gene Families for DNAJB1 Gene

Protein Domains for DNAJB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB1: view

Function for DNAJB1 Gene

Molecular function for DNAJB1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 23921388
GO:0005515 protein binding IPI 17024176
GO:0030544 Hsp70 protein binding IPI 23921388
GO:0051082 unfolded protein binding IDA 21231916
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB1: view
genes like me logo Genes that share phenotypes with DNAJB1: view

Animal Models for DNAJB1 Gene

MGI Knock Outs for DNAJB1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DNAJB1 Gene

Localization for DNAJB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.

Subcellular locations from

Jensen Localization Image for DNAJB1 Gene COMPARTMENTS Subcellular localization image for DNAJB1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 2
mitochondrion 2
cytoskeleton 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DNAJB1: view

Pathways & Interactions for DNAJB1 Gene

genes like me logo Genes that share pathways with DNAJB1: view

Pathways by source for DNAJB1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for DNAJB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
GO:0006986 response to unfolded protein TAS 8975727
GO:0032781 positive regulation of ATPase activity IDA 23921388
GO:0034605 cellular response to heat TAS --
GO:0051085 chaperone mediated protein folding requiring cofactor IEA --
genes like me logo Genes that share ontologies with DNAJB1: view

Drugs & Compounds for DNAJB1 Gene

(2) Drugs for DNAJB1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Pharma Activator 0
glutamine Nutra 137
genes like me logo Genes that share compounds with DNAJB1: view

Transcripts for DNAJB1 Gene

Unigene Clusters for DNAJB1 Gene

DnaJ (Hsp40) homolog, subfamily B, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB1 Gene

No ASD Table

Relevant External Links for DNAJB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB1 Gene

mRNA expression in normal human tissues for DNAJB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB1 Gene

This gene is overexpressed in Whole Blood (x5.3), Brain - Cerebellum (x4.6), and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for DNAJB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB1 Gene

SOURCE GeneReport for Unigene cluster for DNAJB1 Gene Hs.515210

genes like me logo Genes that share expression patterns with DNAJB1: view

Protein tissue co-expression partners for DNAJB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DNAJB1 Gene

Orthologs for DNAJB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJB1 35
  • 93.53 (n)
  • 97.94 (a)
-- 36
  • 80 (a)
  • 98 (a)
(Canis familiaris)
Mammalia DNAJB1 35
  • 93.92 (n)
  • 97.65 (a)
  • 98 (a)
(Mus musculus)
Mammalia Dnajb1 35
  • 90.59 (n)
  • 95.59 (a)
Dnajb1 16
Dnajb1 36
  • 96 (a)
(Pan troglodytes)
Mammalia DNAJB1 35
  • 98.92 (n)
  • 99.12 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajb1 35
  • 92.06 (n)
  • 96.75 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJB1 36
  • 84 (a)
(Gallus gallus)
Aves LOC100858808 35
  • 71.08 (n)
  • 78.31 (a)
(Anolis carolinensis)
Reptilia DNAJB1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb1 35
  • 67.26 (n)
  • 71.64 (a)
(Danio rerio)
Actinopterygii dnajb1a 35
  • 65.46 (n)
  • 68.98 (a)
wufd19c10 35
dnajb1a 36
  • 69 (a)
dnajb1b 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2887 37
  • 38 (a)
CG5001 37
  • 48 (a)
DnaJ-1 37
  • 52 (a)
CG2887 36
  • 42 (a)
CG5001 36
  • 49 (a)
DnaJ-1 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea dnj-13 36
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL008W 35
  • 48.89 (n)
  • 42.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04818g 35
  • 47.44 (n)
  • 41.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 35
  • 46.31 (n)
  • 40.51 (a)
(Oryza sativa)
Liliopsida Os01g0239100 35
  • 54.43 (n)
  • 48.06 (a)
(Triticum aestivum)
Liliopsida Ta.9199 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03732 35
  • 49.39 (n)
  • 40.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes psi1 35
  • 51.14 (n)
  • 46.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for DNAJB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB1 Gene

Gene Tree for DNAJB1 (if available)
Gene Tree for DNAJB1 (if available)

Paralogs for DNAJB1 Gene Pseudogenes for DNAJB1 Gene

genes like me logo Genes that share paralogs with DNAJB1: view

Variants for DNAJB1 Gene

Sequence variations from dbSNP and Humsavar for DNAJB1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7003 -- 14,514,978(-) GTCCC(C/T)GGCAG utr-variant-3-prime
rs8496 -- 14,515,621(-) AGCAG(A/C)TGGAC utr-variant-3-prime
rs743511 -- 14,517,712(-) GAGCC(A/G)ACCCC utr-variant-5-prime, intron-variant
rs755892 -- 14,517,430(-) CTTCT(C/T)TTCCT intron-variant
rs762462 -- 14,517,714(-) AGGAG(A/C)CGACC utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB1 Gene

Variant ID Type Subtype PubMed ID
nsv911128 CNV Loss 21882294

Variation tolerance for DNAJB1 Gene

Residual Variation Intolerance Score: 8.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB1 Gene

Disorders for DNAJB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJB1 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
hepatocellular fibrolamellar carcinoma
  • hepatocellular carcinoma, fibrolamellar
- elite association

Relevant External Links for DNAJB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB1 Gene

Publications for DNAJB1 Gene

  1. Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2. (PMID: 8975727) Hata M. … Ohtsuka K. (Genomics 1996) 2 23 67
  2. Overproduction, purification and characterisation of Tbj1, a novel Type III Hsp40 from Trypanosoma brucei, the African sleeping sickness parasite. (PMID: 19815073) Louw C.A. … Blatch G.L. (Protein Expr. Purif. 2010) 23 67
  3. Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. (PMID: 20026329) Yamamoto S. … Itoh H. (FEBS Lett. 2010) 23 67
  4. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PMID: 20159555) Hageman J. … Kampinga H.H. (Mol. Cell 2010) 23 67
  5. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. (PMID: 20335527) Lenna S. … Scorza R. (J. Immunol. 2010) 23 67

Products for DNAJB1 Gene

Sources for DNAJB1 Gene

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