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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB1 Gene

protein-coding   GIFtS: 64
GCID: GC19M014625

DnaJ (Hsp40) homolog, subfamily B, member 1


(Previous symbol: HSPF1)
 Explore 23 diseases affiliated with
DNAJB1 via our new
 Human Malady Compendium 
Biological research products
for DNAJB1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 11 2     HDj-11
HSPF11 2 3 5     Hdj12
Hsp401 2     DnaJ (Hsp40) Homolog, Subfmaily B, Member 12
RSPH16B1 2     DnaJ Homolog Subfamily B Member 12
Sis11 2     Heat Shock 40kD Protein 12
DnaJ Protein Homolog 12 3     Radial Spoke 16 Homolog B2
Heat Shock 40 KDa Protein 12 3     DNAJ13
Heat Shock Protein 402 3     HDJ13
Human DnaJ Protein 12 3     HSP403

External Ids:    HGNC: 52701   Entrez Gene: 33372   Ensembl: ENSG000001320027   OMIM: 6045725   UniProtKB: P256853   

Export aliases for DNAJB1 gene to outside databases

Previous GC identifers: GC19M014980 GC19M014470 GC19M014486 GC19M014195


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685
Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP

Gene Wiki entry for DNAJB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB1 gene promoter:
         NF-1/L   NF-1   p53   MEF-2   LCR-F1   AP-2gamma   MEF-2A   ZID   aMEF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.2

DNAJB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014625:  view genomic region     (about GC identifiers)

Start:
14,625,582 bp from pter      End:
14,640,049 bp from pter
Size:
14,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 1  
Size: 340 amino acids; 38044 Da
Subunit: Interacts with DNAJC3. Interacts with SRPK1
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the
nucleus, and especially to the nucleoli, upon heat shock
Sequence caution: Sequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136;
5 PDB 3D structures from and Proteopedia for DNAJB1:
1HDJ (3D)        2QLD (3D)        3AGX (3D)        3AGY (3D)        3AGZ (3D)    

Explore the universe of human proteins at neXtProt for DNAJB1: NX_P25685

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25685

  • DNAJB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006136.1  
    ENSEMBL proteins: 
     ENSP00000254322   ENSP00000444212  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for DNAJB1 (HSP40/DNAJB1)
    Enzo Life Sciences proteins for DNAJB1
    OriGene Purified Protein: DNAJB1
    OriGene Protein Over-expression Lysate: DNAJB1
    OriGene Custom Protein Services for DNAJB1 
    GenScript Custom Purified and Recombinant Proteins Services for DNAJB1
    Novus Biologicals DNAJB1 Proteins
    Novus Biologicals DNAJB1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DNAJB1
    Uscn Proteins for DNAJB1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--


    DNAJB1 for ontologies           About GeneDecksing



    DNAJB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DNAJB1
    R&D Systems Antibodies for DNAJB1 (HSP40/DNAJB1)
    Cell Signaling Technology (CST) Antibodies for DNAJB1 
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    Novus Biologicals DNAJB1 Antibodies
    Abcam antibodies for DNAJB1 
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    Assay Products for DNAJB1: 
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    Uscn ELISAs and CLIAs for DNAJB1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DNAJB1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry P25685

    ProtoNet protein and cluster: P25685

    UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685
    Similarity: Contains 1 J domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DNJB1_HUMAN, P25685
    Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP
    Induction: By heat shock

    miRNA
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    miRTarBase miRNAs that target DNAJB1:
    hsa-mir-155 (MIRT001553), hsa-mir-1 (MIRT001371)

    OriGene 3'-UTR Clone: DNAJB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAJB1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB1 (see all 52):
    hsa-miR-4291 hsa-miR-188-5p hsa-miR-1260b hsa-miR-488 hsa-miR-449a hsa-miR-500a hsa-miR-508-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJB1 (see all 7)
    OriGene shRNA RFP: DNAJB1
    OriGene siRNA: DNAJB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DNAJB1

    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DNAJB1 (NM_006145)
    Sino Biological Human cDNA Clone for DNAJB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB1 

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    Search LifeMap BioReagents cell lines for DNAJB1

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031072heat shock protein binding IEA--
    GO:0051082unfolded protein binding IEA--


    DNAJB1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for DNAJB1:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Dnajb1tm1Kate for DNAJB1
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dnajb1):
     normal 

    DNAJB1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Androgen Signaling
    Androgen Signaling1.00
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum1.00
    3Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    CFTR folding and maturation (norm and CF)0.37
    4Measles
    Influenza A0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DNAJB1
        Androgen Signaling

    1 GeneGo (Thomson Reuters) Pathway for DNAJB1
        CFTR folding and maturation (norm and CF)


    2         Kegg Pathways  (Kegg details for DNAJB1):
        Protein processing in endoplasmic reticulum
    Influenza A


    DNAJB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for DNAJB1 (P256852, 3 ENSP000002543224) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48418 I2D: score=2 
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    HSPA8P111423, ENSP000002273784I2D: score=3 STRING: ENSP00000227378
    GLB1P162783, ENSP000003069204I2D: score=2 STRING: ENSP00000306920
    HSPA1BP081073I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein TAS8975727
    GO:0051085chaperone mediated protein folding requiring cofactor IEA--
    GO:0070389chaperone cofactor-dependent protein refolding IDA18620420


    DNAJB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNAJB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB1
    2 Novoseek chemical compound relationships for DNAJB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 38.9 13 8702658 (4), 9321400 (1), 9804845 (1), 9395086 (1) (see all 6)
    glutamine 28.6 4 10942430 (2), 20159555 (1)

    Search CenterWatch for drugs/clinical trials and news about DNAJB1 / DNJB1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB1 gene: 
    NM_006145.1  

    Unigene Cluster for DNAJB1:

    DnaJ (Hsp40) homolog, subfamily B, member 1
    Hs.515210  [show with all ESTs]
    Unigene Representative Sequence: BC002352
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254322(uc002myz.1 uc010xnr.1) ENST00000396969

    miRNA
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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJB1 (see all 52):
    hsa-miR-4291 hsa-miR-188-5p hsa-miR-1260b hsa-miR-488 hsa-miR-449a hsa-miR-500a hsa-miR-508-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJB1 (see all 7)
    OriGene shRNA RFP: DNAJB1
    OriGene siRNA: DNAJB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJB1
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: DNAJB1 (NM_006145)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB1 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB1

    Additional cDNA sequence: 

    AK092989.1 AK296609.1 AK301817.1 AK312624.1 BC002352.2 BC013157.2 BC019827.1 CR536485.1 
    CR541677.1 D49547.1 X62421.1 

    24/37 DOTS entries (see all 37):

    DT.95336008  DT.87018253  DT.92325314  DT.100880070  DT.100880076  DT.100880080  DT.95130729  DT.92470861 
    DT.92470857  DT.92470854  DT.97862657  DT.100880072  DT.100880063  DT.40290333  DT.100880085  DT.100880083 
    DT.121494561  DT.100038711  DT.100880078  DT.102843562  DT.121494423  DT.121494539  DT.87014573  DT.95336006 

    24/797 AceView cDNA sequences (see all 797):

    CR615749 AI581841 BQ214323 BF476727 BU557398 BM784027 AU124319 AA437344 
    CR605869 AA346266 BQ879650 CA307376 BQ440259 AI077721 AA028936 BF447520 
    BM987447 AA115029 BU784585 AI086008 BQ070798 AI521466 CB154502 AI678933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACCAAAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DNAJB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB1

    SOURCE GeneReport for Unigene cluster: Hs.515210
        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJB1: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB1 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008588081 dnaJ homolog subfamily B member 1-like 69.92(n)
    76.69(a)
      100858808  XM_003643562.1  XP_003643610.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB16
    --
    81(a)
    1 ↔ 1
    2(102674898-102679493)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd19c102 wufd19c10 74.4(n)   327244  BC045359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DnaJ-13 chaperone 52(a)
    (best of 3)
      64E5   --
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-131 Protein DNJ-13 55.52(n)
    55.73(a)
      3564910  NM_064067.5  NP_496468.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIS11 Sis1p 45.83(n)
    40.94(a)
      855725   NP_014391.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G205601 DNAJ heat shock protein-like protein 51.17(n)
    46.18(a)
      816578  NM_127616.4  NP_179646.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05623001 hypothetical protein 56.19(n)
    47.73(a)
      4339609  NM_001062855.1  NP_001056320.1 


    ENSEMBL Gene Tree for DNAJB1 (if available)
    TreeFam Gene Tree for DNAJB1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB1 gene
    DNAJB42  DNAJC32  DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJC112  DNAJB62  
    DNAJC72  DNAJB72  DNAJB82  
    12 SIMAP similar genes for DNAJB1 using alignment to 10 protein entries:     DNJB1_HUMAN (see all proteins):
    DNAJB4    DNAJB5    DNAJB13    DNAJB3    DNAJB8    MST104
    HDJ2    DNAJB9    DNAJA1    DNAJA2    DNAJB11    DNAJA4

    DNAJB1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DNAJB1
    PGOHUM00000240463 PGOHUM00000237725


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 NCBI SNPs in DNAJB1 are shown (see all 135    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130201631,2
    C,--14625095(+) AGGCAG/AGAAAT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1450353331,2
    --14625129(+) GTCCTC/GGGCAG 1 -- ds50010--------
    rs104117381,2
    C,F,A,H,--14625170(+) GGACGC/TCCAGC 1 -- ds500114Minor allele frequency- T:0.13NS EA NA CSA WA 792
    rs1483040941,2
    --14625297(+) AGGAGA/CCAGAC 1 -- ds50010--------
    rs1163391141,2
    --14625325(+) CTACTT/CTGACT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1847328591,2
    --14625331(+) TGACTC/GCAACC 1 -- ds50010--------
    rs169797151,2
    C,--14625348(+) AAAAAA/CTGATC 1 -- ds50014Minor allele frequency- C:0.02NA WA 258
    rs1404335741,2
    --14625396(+) CCCCGA/TGTCTG 1 -- ds50010--------
    rs104175051,2
    C,F,A,H,--14625447(+) ACTTAC/TGTTTC 1 -- ds500115Minor allele frequency- T:0.17NA NS EA CSA WA 796
    rs1144210831,2
    F,--14625504(+) TTGAAT/GTTGGA 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for DNAJB1 (14625582 - 14640049 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNAJB1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DNAJB1 for disorders           About GeneDecksing

    OMIM gene information: 604572    OMIM disorders: --

    20/23 diseases for DNAJB1 (see all 23):    About MalaCards
    sleeping sickness    atrial fibrillation    mucolipidosis    neurodegenerative disease
    herpes simplex    fanconi's anemia    mental disorders    bipolar disorder
    huntington's disease    hepatitis b    parkinson's disease    anemia
    influenza    immunodeficiency    breast cancer    hepatitis
    pneumonia    schizophrenia    tuberculosis    malaria

    1 disease from the University of Copenhagen DISEASES database for DNAJB1:
    Huntington's disease

    4 Novoseek disease relationships for DNAJB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 66.6 27 8975727 (2), 9546042 (1), 10330192 (1), 17239655 (1) (see all 16)
    neurodegenerative diseases 16.2 1 11044589 (1)
    tumors 3.9 2 15176219 (1), 10725457 (1)
    immunodeficiency 0 1 11932435 (1)

    Human Genome Epidemiology (HuGE) Navigator: DNAJB1 (4 documents)

    Export disorders for DNAJB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB1 gene, integrated from 9 sources (see all 135):
    (articles sorted by number of sources associating them with DNAJB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2. (PubMed id 8975727)1, 2, 3, 9 Hata M.... Ohtsuka K. (1996)
    2. Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ. (PubMed id 8250930)1, 2, 3 Ohtsuka K. (1993)
    3. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PubMed id 9920933)1, 2, 9 Melville M.W....Katze M.G. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain. (PubMed id 8764402)1, 2 Qian Y.Q.... McColl D.J. (1996)
    6. Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells. (PubMed id 1586970)1, 2 Hattori H.... Ohtsuka K. (1992)
    7. A human homologue of the Escherichia coli DnaJ heat-shock protein. (PubMed id 1754405)1, 2 Raabe T. and Manley J.L. (1991)
    8. Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef-mediated enhancement of viral gene expression and replication. (PubMed id 16179353)1, 9 Kumar M. and Mitra D. (2005)
    9. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. (PubMed id 10330192)1, 9 Ballinger C.A....Patterson C. (1999)
    10. Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. (PubMed id 20026329)1, 9 Yamamoto S....Itoh H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3337 HGNC: 5270 AceView: DNAJB1 Ensembl:ENSG00000132002 euGenes: HUgn3337
    ECgene: DNAJB1 Kegg: 3337 H-InvDB: DNAJB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJB1 gene:
    Search GeneIP for patents involving DNAJB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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