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Aliases for DNAJB1 Gene

Aliases for DNAJB1 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 1 2 3
  • HSPF1 3 4 6
  • Heat Shock 40 KDa Protein 1 3 4
  • DnaJ Protein Homolog 1 3 4
  • Human DnaJ Protein 1 3 4
  • Hsp40 3 4
  • Hdj1 3 4
  • Radial Spoke 16 Homolog B (Chlamydomonas) 2
  • DnaJ Homolog Subfamily B Member 1 3
  • Radial Spoke 16 Homolog B 3
  • Heat Shock Protein 40 4
  • RSPH16B 3
  • DNAJ1 4
  • HDj-1 4
  • Sis1 3

External Ids for DNAJB1 Gene

Previous Symbols for DNAJB1 Gene

  • HSPF1

Summaries for DNAJB1 Gene

GeneCards Summary for DNAJB1 Gene

DNAJB1 (DnaJ (Hsp40) Homolog, Subfamily B, Member 1) is a Protein Coding gene. Diseases associated with DNAJB1 include hepatocellular fibrolamellar carcinoma and sleeping sickness. Among its related pathways are Androgen Signaling and Protein processing in endoplasmic reticulum. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB1 Gene

  • Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP

Gene Wiki entry for DNAJB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB1 Gene

Genomics for DNAJB1 Gene

Genomic Location for DNAJB1 Gene

Start:
14,514,769 bp from pter
End:
14,529,770 bp from pter
Size:
15,002 bases
Orientation:
Minus strand

Genomic View for DNAJB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB1 Gene

Regulatory Elements for DNAJB1 Gene

Proteins for DNAJB1 Gene

  • Protein details for DNAJB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25685-DNJB1_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 1
    Protein Accession:
    P25685
    Secondary Accessions:
    • B4DX52

    Protein attributes for DNAJB1 Gene

    Size:
    340 amino acids
    Molecular mass:
    38044 Da
    Quaternary structure:
    • Interacts with DNAJC3. Interacts with SRPK1.
    SequenceCaution:
    • Sequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJB1 Gene

    Alternative splice isoforms for DNAJB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB1 Gene

Proteomics data for DNAJB1 Gene at MOPED

Post-translational modifications for DNAJB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3 and Lys286

No data available for DME Specific Peptides for DNAJB1 Gene

Domains for DNAJB1 Gene

Gene Families for DNAJB1 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJB1 Gene

UniProtKB/Swiss-Prot:

DNJB1_HUMAN
Domain:
  • Contains 1 J domain.:
    • P25685
genes like me logo Genes that share domains with DNAJB1: view

Function for DNAJB1 Gene

Molecular function for DNAJB1 Gene

UniProtKB/Swiss-Prot Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP
UniProtKB/Swiss-Prot Induction: By heat shock.

Gene Ontology (GO) - Molecular Function for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 23921388
GO:0005515 protein binding IPI 17024176
GO:0030544 Hsp70 protein binding IPI 23921388
GO:0051082 unfolded protein binding IDA 21231916
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB1: view

Phenotypes for DNAJB1 Gene

genes like me logo Genes that share phenotypes with DNAJB1: view

Animal Models for DNAJB1 Gene

MGI Knock Outs for DNAJB1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DNAJB1 Gene

Localization for DNAJB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB1 Gene COMPARTMENTS Subcellular localization image for DNAJB1 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 2
mitochondrion 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DNAJB1: view

Pathways for DNAJB1 Gene

genes like me logo Genes that share pathways with DNAJB1: view

Pathways by source for DNAJB1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for DNAJB1 Gene
1 Qiagen pathway for DNAJB1 Gene

Gene Ontology (GO) - Biological Process for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
GO:0006986 response to unfolded protein TAS 8975727
GO:0032781 positive regulation of ATPase activity IDA 23921388
GO:0034605 cellular response to heat TAS --
GO:0051085 chaperone mediated protein folding requiring cofactor IEA --
genes like me logo Genes that share ontologies with DNAJB1: view

Compounds for DNAJB1 Gene

(2) Novoseek inferred chemical compound relationships for DNAJB1 Gene

Compound -log(P) Hits PubMed IDs
atp 38.9 9
glutamine 28.6 3
genes like me logo Genes that share compounds with DNAJB1: view

Transcripts for DNAJB1 Gene

Unigene Clusters for DNAJB1 Gene

DnaJ (Hsp40) homolog, subfamily B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB1 Gene

No ASD Table

Relevant External Links for DNAJB1 Gene

GeneLoc Exon Structure for
DNAJB1
ECgene alternative splicing isoforms for
DNAJB1

Expression for DNAJB1 Gene

mRNA expression in normal human tissues for DNAJB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB1 Gene

This gene is overexpressed in Whole Blood (5.3), Brain - Cerebellum (4.6), and Brain - Cerebellar Hemisphere (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB1 Gene

SOURCE GeneReport for Unigene cluster for DNAJB1 Gene Hs.515210

genes like me logo Genes that share expressions with DNAJB1: view

Orthologs for DNAJB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB1 36
  • 98.92 (n)
  • 99.12 (a)
DNAJB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 80 (a)
OneToMany
DNAJB1 36
  • 93.53 (n)
  • 97.94 (a)
DNAJB1 37
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DNAJB1 36
  • 93.92 (n)
  • 97.65 (a)
DNAJB1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb1 36
  • 90.59 (n)
  • 95.59 (a)
Dnajb1 16
Dnajb1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb1 36
  • 92.06 (n)
  • 96.75 (a)
chicken
(Gallus gallus)
Aves LOC100858808 36
  • 71.08 (n)
  • 78.31 (a)
lizard
(Anolis carolinensis)
Reptilia DNAJB1 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb1 36
  • 67.26 (n)
  • 71.64 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajb1a 36
  • 65.46 (n)
  • 68.98 (a)
dnajb1a 37
  • 69 (a)
OneToMany
dnajb1b 37
  • 66 (a)
OneToMany
wufd19c10 36
fruit fly
(Drosophila melanogaster)
Insecta CG2887 37
  • 42 (a)
ManyToMany
CG5001 37
  • 49 (a)
ManyToMany
DnaJ-1 37
  • 51 (a)
ManyToMany
CG5001 38
  • 48 (a)
CG2887 38
  • 38 (a)
DnaJ-1 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-13 37
  • 54 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL008W 36
  • 48.89 (n)
  • 42.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 36
  • 46.31 (n)
  • 40.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04818g 36
  • 47.44 (n)
  • 41.38 (a)
rice
(Oryza sativa)
Liliopsida Os01g0239100 36
  • 54.43 (n)
  • 48.06 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9199 36
bread mold
(Neurospora crassa)
Ascomycetes NCU03732 36
  • 49.39 (n)
  • 40.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes psi1 36
  • 51.14 (n)
  • 46.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToMany
Species with no ortholog for DNAJB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB1 Gene

ENSEMBL:
Gene Tree for DNAJB1 (if available)
TreeFam:
Gene Tree for DNAJB1 (if available)

Paralogs for DNAJB1 Gene

Pseudogenes.org Pseudogenes for DNAJB1 Gene

genes like me logo Genes that share paralogs with DNAJB1: view

Variants for DNAJB1 Gene

Sequence variations from dbSNP and Humsavar for DNAJB1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7003 -- 14,514,978(-) GTCCC(C/T)GGCAG utr-variant-3-prime
rs8496 -- 14,515,621(-) AGCAG(A/C)TGGAC utr-variant-3-prime
rs743511 -- 14,517,712(-) GAGCC(A/G)ACCCC utr-variant-5-prime, intron-variant
rs755892 -- 14,517,430(-) CTTCT(C/T)TTCCT intron-variant
rs762462 -- 14,517,714(-) AGGAG(A/C)CGACC utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB1 Gene

Variant ID Type Subtype PubMed ID
nsv911128 CNV Loss 21882294

Relevant External Links for DNAJB1 Gene

HapMap Linkage Disequilibrium report
DNAJB1

Disorders for DNAJB1 Gene

(1) University of Copenhagen DISEASES for DNAJB1 Gene

(4) Novoseek inferred disease relationships for DNAJB1 Gene

Disease -log(P) Hits PubMed IDs
shock 66.6 17
neurodegenerative diseases 16.2 1
tumors 3.9 2
immunodeficiency 0 1

Relevant External Links for DNAJB1

Genetic Association Database (GAD)
DNAJB1
Human Genome Epidemiology (HuGE) Navigator
DNAJB1
genes like me logo Genes that share disorders with DNAJB1: view

No data available for UniProtKB/Swiss-Prot for DNAJB1 Gene

Publications for DNAJB1 Gene

  1. Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2. (PMID: 8975727) Hata M. … Ohtsuka K. (Genomics 1996) 2 3 4 23
  2. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PMID: 9920933) Melville M.W. … Katze M.G. (J. Biol. Chem. 1999) 3 4 23
  3. Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ. (PMID: 8250930) Ohtsuka K. (Biochem. Biophys. Res. Commun. 1993) 2 3 4
  4. Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells. (PMID: 1586970) Hattori H. … Ohtsuka K. (Cell Struct. Funct. 1992) 3 4
  5. A human homologue of the Escherichia coli DnaJ heat-shock protein. (PMID: 1754405) Raabe T. … Manley J.L. (Nucleic Acids Res. 1991) 3 4

Products for DNAJB1 Gene

Sources for DNAJB1 Gene

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