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Aliases for DNAJA4 Gene

Aliases for DNAJA4 Gene

  • DnaJ (Hsp40) Homolog, Subfamily A, Member 4 2 3
  • DnaJ Homolog Subfamily A Member 4 3
  • MSTP104 3
  • PRO1472 3
  • MST104 3

External Ids for DNAJA4 Gene

Previous GeneCards Identifiers for DNAJA4 Gene

  • GC15P074635
  • GC15P071646
  • GC15P076132
  • GC15P076272
  • GC15P076343
  • GC15P078556
  • GC15P055314

Summaries for DNAJA4 Gene

GeneCards Summary for DNAJA4 Gene

DNAJA4 (DnaJ (Hsp40) Homolog, Subfamily A, Member 4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA4 Gene

Genomics for DNAJA4 Gene

Regulatory Elements for DNAJA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJA4 Gene

Start:
78,264,086 bp from pter
End:
78,282,196 bp from pter
Size:
18,111 bases
Orientation:
Plus strand

Genomic View for DNAJA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA4 Gene

Proteins for DNAJA4 Gene

  • Protein details for DNAJA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW22-DNJA4_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 4
    Protein Accession:
    Q8WW22
    Secondary Accessions:
    • E9PDM9
    • Q6AW87
    • Q8N5Z4
    • Q8N7P2

    Protein attributes for DNAJA4 Gene

    Size:
    397 amino acids
    Molecular mass:
    44798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA4 Gene

Proteomics data for DNAJA4 Gene at MOPED

Post-translational modifications for DNAJA4 Gene

  • Ubiquitination at Lys32 and Lys126
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJA4 Gene

Domains for DNAJA4 Gene

Gene Families for DNAJA4 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Suggested Antigen Peptide Sequences for DNAJA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW22

UniProtKB/Swiss-Prot:

DNJA4_HUMAN :
  • Q8WW22
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 1 CR-type zinc finger.
genes like me logo Genes that share domains with DNAJA4: view

Function for DNAJA4 Gene

Gene Ontology (GO) - Molecular Function for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
GO:0005524 ATP binding IEA --
GO:0031072 heat shock protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051082 unfolded protein binding IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

Phenotypes for DNAJA4 Gene

GenomeRNAi human phenotypes for DNAJA4:
genes like me logo Genes that share phenotypes with DNAJA4: view

Animal Model Products

CRISPR Products

miRNA for DNAJA4 Gene

miRTarBase miRNAs that target DNAJA4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJA4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJA4 Gene

Localization for DNAJA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA4 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJA4 Gene COMPARTMENTS Subcellular localization image for DNAJA4 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 21231916
GO:0016020 membrane IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

Pathways for DNAJA4 Gene

SuperPathways for DNAJA4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
GO:0009408 response to heat IEA --
GO:0042026 protein refolding IDA 21231916
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

No data available for Pathways by source for DNAJA4 Gene

Transcripts for DNAJA4 Gene

Unigene Clusters for DNAJA4 Gene

DnaJ (Hsp40) homolog, subfamily A, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJA4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DNAJA4 Gene

GeneLoc Exon Structure for
DNAJA4
ECgene alternative splicing isoforms for
DNAJA4

Expression for DNAJA4 Gene

mRNA expression in normal human tissues for DNAJA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJA4 Gene

SOURCE GeneReport for Unigene cluster for DNAJA4 Gene Hs.513053

genes like me logo Genes that share expressions with DNAJA4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJA4 Gene

Orthologs for DNAJA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJA4 35
  • 99.5 (n)
  • 99.75 (a)
DNAJA4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJA4 35
  • 92.49 (n)
  • 94.13 (a)
DNAJA4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA4 35
  • 91.18 (n)
  • 96.98 (a)
DNAJA4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnaja4 35
  • 90.09 (n)
  • 93.2 (a)
Dnaja4 16
Dnaja4 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJA4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA4 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnaja4 35
  • 90.06 (n)
  • 92.96 (a)
chicken
(Gallus gallus)
Aves DNAJA4 35
  • 76.29 (n)
  • 81.01 (a)
DNAJA4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA4 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64353 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja4.1 35
  • 70.37 (n)
  • 73.99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10348 35
zebrafish
(Danio rerio)
Actinopterygii dnaja 35
  • 67.34 (n)
  • 68.27 (a)
DNAJA4 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005981 35
  • 60.25 (n)
  • 58.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Droj2 35
  • 62.84 (n)
  • 61.99 (a)
Droj2 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-12 35
  • 56.57 (n)
  • 51.65 (a)
dnj-12 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAJ1 38
YDJ1 36
  • 47 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2672 35
corn
(Zea mays)
Liliopsida Zm.14501 35
rice
(Oryza sativa)
Liliopsida Os02g0656500 35
  • 54.91 (n)
  • 51.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10384 36
  • 60 (a)
OneToMany
Species with no ortholog for DNAJA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJA4 Gene

ENSEMBL:
Gene Tree for DNAJA4 (if available)
TreeFam:
Gene Tree for DNAJA4 (if available)

Paralogs for DNAJA4 Gene

Paralogs for DNAJA4 Gene

genes like me logo Genes that share paralogs with DNAJA4: view

Variants for DNAJA4 Gene

Sequence variations from dbSNP and Humsavar for DNAJA4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs6996 -- 78,281,145(+) ATCAT(A/T)TGCTG utr-variant-3-prime
rs967819 -- 78,275,228(+) GGCCC(G/T)GGGCA intron-variant
rs967820 -- 78,275,333(+) CTCTT(C/T)TGTCA intron-variant
rs967821 -- 78,275,511(+) GATGG(G/T)CAAAA reference, synonymous-codon
rs2037347 -- 78,266,167(-) CGGAC(C/T)ACAAT intron-variant, upstream-variant-2KB

Relevant External Links for DNAJA4 Gene

HapMap Linkage Disequilibrium report
DNAJA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJA4 Gene

Disorders for DNAJA4 Gene

Relevant External Links for DNAJA4

Genetic Association Database (GAD)
DNAJA4
genes like me logo Genes that share disorders with DNAJA4: view

No data available for UniProtKB/Swiss-Prot for DNAJA4 Gene

Publications for DNAJA4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3

Products for DNAJA4 Gene

Sources for DNAJA4 Gene

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