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Aliases for DNAJA4 Gene

Aliases for DNAJA4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A4 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 4 2 3
  • DnaJ Homolog Subfamily A Member 4 3
  • MSTP104 3
  • PRO1472 3
  • MST104 3

External Ids for DNAJA4 Gene

Previous GeneCards Identifiers for DNAJA4 Gene

  • GC15P074635
  • GC15P071646
  • GC15P076132
  • GC15P076272
  • GC15P076343
  • GC15P078556
  • GC15P055314

Summaries for DNAJA4 Gene

GeneCards Summary for DNAJA4 Gene

DNAJA4 (DnaJ Heat Shock Protein Family (Hsp40) Member A4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA4 Gene

Genomics for DNAJA4 Gene

Regulatory Elements for DNAJA4 Gene

Enhancers for DNAJA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F078373 1.1 Ensembl ENCODE 8.4 +110.5 110467 3.1 PKNOX1 DMAP1 THRB RARA YY1 GLIS2 ZNF207 RCOR1 FOS CREM DNAJA4 LOC645752 CSPG4P13 LOC105370912 GC15P078347
GH15F078315 1 Ensembl ENCODE 8.9 +52.4 52411 2.2 BCOR CTCF MAX ZMYM3 TSC22D4 ZNF140 BRCA1 ZIC2 RAD21 SMC3 IREB2 ENSG00000259562 WDR61 ENSG00000260988 CRABP1 ACSBG1 CHRNA5 DNAJA4 GC15P078331
GH15F078263 0.8 ENCODE 10 +1.6 1640 4.1 CTCF TAF1 MAX RAD21 ZNF121 E2F1 POLR2A ELK1 HSF1 FOS CRABP1 ADAMTS7P3 IREB2 DNAJA4 ENSG00000259562 LOC645752 LOC105370911 LOC105370910
GH15F078278 0.8 ENCODE 9.4 +14.5 14468 0.2 SIX4 CTCF PKNOX1 SIN3A RAD21 GATA3 CTBP1 MTA3 ZBTB48 SCRT2 DNAJA4 LOC105370910 LOC105370911
GH15F078298 1.1 ENCODE 6.2 +35.4 35402 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ENSG00000259562 ENSG00000259322 HYKK LOC645752 DNAJA4 ENSG00000277482
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJA4 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000411876 914 2001 CTCF SMARCC1 MAZ TAF1 MAX CHD1 MNT RAD21 ZNF121 E2F1

Genomic Location for DNAJA4 Gene

Chromosome:
15
Start:
78,264,086 bp from pter
End:
78,282,196 bp from pter
Size:
18,111 bases
Orientation:
Plus strand

Genomic View for DNAJA4 Gene

Genes around DNAJA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA4 Gene

Proteins for DNAJA4 Gene

  • Protein details for DNAJA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW22-DNJA4_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 4
    Protein Accession:
    Q8WW22
    Secondary Accessions:
    • E9PDM9
    • Q6AW87
    • Q8N5Z4
    • Q8N7P2

    Protein attributes for DNAJA4 Gene

    Size:
    397 amino acids
    Molecular mass:
    44798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA4 Gene

Post-translational modifications for DNAJA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJA4 Gene

Domains & Families for DNAJA4 Gene

Gene Families for DNAJA4 Gene

Suggested Antigen Peptide Sequences for DNAJA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW22

UniProtKB/Swiss-Prot:

DNJA4_HUMAN :
  • Contains 1 J domain.
  • Contains 1 CR-type zinc finger.
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 1 CR-type zinc finger.
genes like me logo Genes that share domains with DNAJA4: view

Function for DNAJA4 Gene

Gene Ontology (GO) - Molecular Function for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
GO:0005524 ATP binding IEA --
GO:0031072 heat shock protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051082 unfolded protein binding IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view
genes like me logo Genes that share phenotypes with DNAJA4: view

Animal Models for DNAJA4 Gene

MGI Knock Outs for DNAJA4:

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJA4 Gene

Localization for DNAJA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA4 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJA4 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 21231916
GO:0016020 membrane IEA,IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

Pathways & Interactions for DNAJA4 Gene

SuperPathways for DNAJA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0009408 response to heat IEA --
GO:0042026 protein refolding IDA 21231916
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJA4 Gene

Transcripts for DNAJA4 Gene

Unigene Clusters for DNAJA4 Gene

DnaJ (Hsp40) homolog, subfamily A, member 4:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DNAJA4 Gene

GeneLoc Exon Structure for
DNAJA4
ECgene alternative splicing isoforms for
DNAJA4

Expression for DNAJA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJA4 Gene

This gene is overexpressed in Testis (15.9) and Bone marrow mesenchymal stem cell (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJA4 Gene



Protein tissue co-expression partners for DNAJA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJA4 Gene:

DNAJA4

SOURCE GeneReport for Unigene cluster for DNAJA4 Gene:

Hs.513053
genes like me logo Genes that share expression patterns with DNAJA4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJA4 Gene

Orthologs for DNAJA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJA4 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia DNAJA4 34 35
  • 92.49 (n)
dog
(Canis familiaris)
Mammalia DNAJA4 34 35
  • 91.18 (n)
mouse
(Mus musculus)
Mammalia Dnaja4 34 16 35
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Dnaja4 34
  • 90.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA4 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJA4 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA4 34 35
  • 76.29 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJA4 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja4.1 34
  • 70.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64353 34
zebrafish
(Danio rerio)
Actinopterygii dnaja 34
  • 67.34 (n)
DNAJA4 35
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10348 34
fruit fly
(Drosophila melanogaster)
Insecta Droj2 34 35
  • 62.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005981 34
  • 60.25 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-12 34 35
  • 56.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 35
  • 47 (a)
OneToMany
CAJ1 37
rice
(Oryza sativa)
Liliopsida Os02g0656500 34
  • 54.91 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2672 34
corn
(Zea mays)
Liliopsida Zm.14501 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10384 35
  • 60 (a)
OneToMany
Species where no ortholog for DNAJA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJA4 Gene

ENSEMBL:
Gene Tree for DNAJA4 (if available)
TreeFam:
Gene Tree for DNAJA4 (if available)

Paralogs for DNAJA4 Gene

Variants for DNAJA4 Gene

Sequence variations from dbSNP and Humsavar for DNAJA4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152846 -- 78,266,515(+) TCTGG(C/T)AGGCC intron-variant
rs10152977 -- 78,268,585(+) ATTTT(G/T)TGGAG intron-variant
rs10607415 -- 78,267,135(+) gtgtg(-/TA)tgtga intron-variant
rs111257821 -- 78,263,083(+) CACTG(C/T)GCTAG intron-variant, upstream-variant-2KB
rs111753185 -- 78,275,042(+) CCAAA(A/C)CGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJA4 Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259
nsv570200 CNV loss 21841781

Variation tolerance for DNAJA4 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA4 Gene

Disorders for DNAJA4 Gene

Relevant External Links for DNAJA4

Genetic Association Database (GAD)
DNAJA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJA4

No disorders were found for DNAJA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJA4 Gene

Publications for DNAJA4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for DNAJA4 Gene

Sources for DNAJA4 Gene

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