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DNAJA4 Gene

protein-coding   GIFtS: 52
GCID: GC15P078556

DnaJ (Hsp40) Homolog, Subfamily A, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily A, Member 41 2
MST1042
MSTP1042
PRO14722
DnaJ Homolog Subfamily A Member 42

External Ids:    HGNC: 148851   Entrez Gene: 554662   Ensembl: ENSG000001404037   UniProtKB: Q8WW223   

Export aliases for DNAJA4 gene to outside databases

Previous GC identifers: GC15P074635 GC15P071646 GC15P076132 GC15P076272 GC15P076343 GC15P055314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJA4 Gene:
DNAJA4 (DnaJ (Hsp40) homolog, subfamily A, member 4) is a protein-coding gene. Diseases associated with DNAJA4 include alveolar rhabdomyosarcoma, and transient cerebral ischemia. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJA4 gene promoter:
         Pax-5   c-Myb   POU6F1 (c2)   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJA4 promoter sequence
   Search Chromatin IP Primers for DNAJA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24.1

DNAJA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJA4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P078556:  view genomic region     (about GC identifiers)

Start:
78,556,428 bp from pter      End:
78,574,538 bp from pter
Size:
18,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNJA4_HUMAN, Q8WW22 (See protein sequence)
Recommended Name: DnaJ homolog subfamily A member 4 precursor  
Size: 397 amino acids; 44798 Da
Sequence caution: Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: E9PDM9 Q6AW87 Q8N5Z4 Q8N7P2
Alternative splicing: 3 isoforms:  Q8WW22-1   Q8WW22-2   Q8WW22-3   (No experimental confirmation available. Ref.5 (AAH31044) sequence is in conflict in position: 1:M->T)

Explore the universe of human proteins at neXtProt for DNAJA4: NX_Q8WW22

Explore proteomics data for DNAJA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys126
  • Modification sites at PhosphoSitePlus

  • See DNAJA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123654.1  NP_001123655.1  NP_061072.3  

    ENSEMBL proteins: 
     ENSP00000378324   ENSP00000438263   ENSP00000395191   ENSP00000407136   ENSP00000443962  
     ENSP00000339581   ENSP00000378321   ENSP00000441946   ENSP00000413499  

    DNAJA4 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
    OriGene Custom Protein Services for DNAJA4
    GenScript Custom Purified and Recombinant Proteins Services for DNAJA4
    Novus Biologicals DNAJA4 Protein
    Novus Biologicals DNAJA4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJA4

    DNAJA4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DNAJA4
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    ThermoFisher Antibodies for DNAJA4
    LSBio Antibodies in human, mouse, rat for DNAJA4

    DNAJA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DNAJA4
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    Cloud-Clone Corp. ELISAs for DNAJA4
    Cloud-Clone Corp. CLIAs for DNAJA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    Selected InterPro protein domains (see all 6):
     IPR008971 HSP40/DnaJ_pept-bd
     IPR012724 DnaJ
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q8WW22

    ProtoNet protein and cluster: Q8WW22

    2 Blocks protein domains:
    IPB001305 DnaJ central domain (CXXCXGXG)
    IPB003095 DnaJ protein family signature


    UniProtKB/Swiss-Prot: DNJA4_HUMAN, Q8WW22
    Similarity: Contains 1 CR-type zinc finger
    Similarity: Contains 1 J domain


    DNAJA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0031072heat shock protein binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    DNAJA4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJA4:
     Increased S DNA content, incre  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Dnaja4 (no phenotypes)

    DNAJA4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJA4:
    hsa-mir-16-5p (MIRT031496), hsa-mir-30a-5p (MIRT028423)

    Block miRNA regulation of human, mouse, rat DNAJA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJA4 (see all 25):
    hsa-miR-181c hsa-miR-449c* hsa-miR-4267 hsa-miR-421 hsa-miR-9 hsa-miR-28-5p hsa-miR-181b hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJA4
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAJA4

    Clone
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    OriGene clones in human, mouse for DNAJA4 (see all 24)
    OriGene ORF clones in mouse, rat for DNAJA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DNAJA4 (NM_001130183)
    Sino Biological Human cDNA Clone for DNAJA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DNAJA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJA4_HUMAN, Q8WW22: Membrane; Lipid-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    DNAJA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA4: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJA4 (Q8WW223 ENSP000003783244) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3BP4Q9P0V33, ENSP000003402374I2D: score=1 STRING: ENSP00000340237
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ERGENSP000003818914STRING: ENSP00000381891
    SNRNP40ENSP000002636944STRING: ENSP00000263694
    SSBP3ENSP000003603714STRING: ENSP00000360371
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0009408response to heat IEA--

    DNAJA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJA4 (DNJA4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJA4 gene (3 alternative transcripts): 
    NM_001130182.1  NM_001130183.1  NM_018602.3  

    Unigene Cluster for DNAJA4:

    DnaJ (Hsp40) homolog, subfamily A, member 4
    Hs.513053  [show with all ESTs]
    Unigene Representative Sequence: NM_018602
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394855(uc002bdi.3) ENST00000489435 ENST00000440911 ENST00000423642
    ENST00000483802 ENST00000343789(uc002bdk.3 uc002bdm.2) ENST00000394852(uc002bdj.2)
    ENST00000542636 ENST00000446172 ENST00000485075(uc002bdl.3) ENST00000493321
    ENST00000480425
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJA4 (see all 25):
    hsa-miR-181c hsa-miR-449c* hsa-miR-4267 hsa-miR-421 hsa-miR-9 hsa-miR-28-5p hsa-miR-181b hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJA4
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJA4
    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJA4 (see all 24)
    OriGene ORF clones in mouse, rat for DNAJA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DNAJA4 (NM_001130183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAJA4
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA4
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJA4
      QuantiFast Probe-based Assays in human, mouse, rat DNAJA4

    Additional mRNA sequence: 

    AF173388.1 AK025069.1 AK090898.1 AK096616.1 AK098079.1 AL133096.1 AL133431.1 AL133432.1 
    AL133433.1 AL133434.1 BC021720.2 BC031044.1 BX648710.1 

    10 DOTS entries:

    DT.92418930  DT.318530  DT.100791203  DT.95374605  DT.99958665  DT.442255  DT.95155309  DT.75100068 
    DT.91991729  DT.100024835 

    Selected AceView cDNA sequences (see all 212):

    AA778475 BM988243 F02973 BU607771 CB306664 BM683420 N35178 CB529209 
    AI304871 AI364029 AI567233 AA633667 BM761377 T32682 AA988883 CA450248 
    BQ943946 AI566517 AF116663 CA450098 Z40407 BU687986 CA392172 BF055288 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA4 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:        -     -           -     -                             -                 -                           
    SP2:                          -     -                             -                 -                           
    SP3:                                -                             -                 -                           
    SP4:                          -     -     -                       -                                             
    SP5:                          -     -                                                                           


    ECgene alternative splicing isoforms for DNAJA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTAAGGT
    DNAJA4 Expression
    About this image


    DNAJA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    DNAJA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513053
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA4: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJA4
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA4
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJA4
    QuantiFast Probe-based Assays in human, mouse, rat DNAJA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJA4 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnaja41 , 5 DnaJ (Hsp40) homolog, subfamily A, member 41, 5 90.09(n)1
    93.2(a)1
      9 (29.72 cM)5
    582331  NM_021422.41  NP_067397.11 
     546988735 
    chicken
    (Gallus gallus)
    Aves DNAJA41 DnaJ (Hsp40) homolog, subfamily A, member 4 76.29(n)
    81.01(a)
      415360  XM_413746.4  XP_413746.4 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJA46
    DnaJ (Hsp40) homolog, subfamily A, member 4
    79(a)
    1 ↔ 1
    GL343486.1(80976-92919)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643532 hypothetical protein MGC64353 74.95(n)    BC054199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnaja1 DnaJ (Hsp40) homolog, subfamily A member 67.34(n)
    68.27(a)
      373115  XM_002666751.3  XP_002666797.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Droj21 DnaJ-like-2 62.84(n)
    61.99(a)
      41646  NM_169522.2  NP_731807.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-121 dnj-12 56.57(n)
    51.65(a)
      173341  NM_061169.5  NP_493570.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAJ1(YER048C)4 Nuclear type II J heat shock protein of the E. coli more   --   5(248157-246982) 856772  NP_010967.1 
    rice
    (Oryza sativa)
    Liliopsida AK061922.12   -- 70.64(n)    AK061922.1 


    ENSEMBL Gene Tree for DNAJA4 (if available)
    TreeFam Gene Tree for DNAJA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJA4 gene
    DNAJA22  DNAJA12  DNAJB112  
    Selected SIMAP similar genes for DNAJA4 using alignment to 7 protein entries:     DNJA4_HUMAN (see all proteins) (see all similar genes):
    MST104    DKFZp434N1728    DNAJA1    HDJ2    DNAJC5B    DNAJB6
    DNAJA2    DNAJC25    DNAJC1    DNAJB8    DNAJA3    DNAJC17
    DNAJB12    DNAJC18    DNAJB4    DNAJB2    DNAJB5    DNAJC10

    DNAJA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJA4 (see all 516)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs592072611,2
    C,F--78554572(+) CCAGAC/TTGGTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1410455651,2
    --78554635(+) GATTAC/GAGGTG 1 -- us2k10--------
    rs1865959091,2
    --78554710(+) AAATCA/GTCTTC 1 -- us2k10--------
    rs1917726421,2
    --78554775(+) TGACGC/TTGAAT 1 -- us2k10--------
    rs748166801,2
    --78554798(+) TGTTGC/GTGTCT 1 -- us2k10--------
    rs1389753151,2
    --78554809(+) GTTCAA/GTCTTT 1 -- us2k10--------
    rs1433147521,2
    C--78554883(+) GAAGAG/TAATCA 1 -- us2k10--------
    rs1831167721,2
    --78554928(+) CCCCCA/CACCCC 1 -- us2k10--------
    rs1469388121,2
    --78554934(+) ACCCCC/GAAAAA 1 -- us2k10--------
    rs1173656561,2
    C,F--78554941(+) AAAAGC/TATCAA 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for DNAJA4 (78556428 - 78574538 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJA4: --
    Human Gene Mutation Database (HGMD): DNAJA4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJA4
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    10 diseases for DNAJA4:    
    About MalaCards
    alveolar rhabdomyosarcoma    transient cerebral ischemia    rhabdomyosarcoma    ischemia
    cerebritis    pancreatic cancer    tuberculosis    pancreatitis
    malaria    neuroblastoma


    DNAJA4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNAJA4

    Export disorders for DNAJA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJA4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DNAJA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (BMB Rep 2010)
    7. Hsp40 chaperones promote degradation of the HERG potassium channel. (PubMed id 19940115)1 Walker V.E....Shrier A. (J. Biol. Chem. 2010)
    8. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (Proteomics 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55466 HGNC: 14885 AceView: DNAJA4 Ensembl:ENSG00000140403 euGenes: HUgn55466
    ECgene: DNAJA4 H-InvDB: DNAJA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJA4 gene:
    Search GeneIP for patents involving DNAJA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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