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Aliases for DNAJA4 Gene

Aliases for DNAJA4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A4 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 4 2 3
  • MSTP104 3
  • PRO1472 3
  • MST104 3

External Ids for DNAJA4 Gene

Previous GeneCards Identifiers for DNAJA4 Gene

  • GC15P074635
  • GC15P071646
  • GC15P076132
  • GC15P076272
  • GC15P076343
  • GC15P078556
  • GC15P055314

Summaries for DNAJA4 Gene

GeneCards Summary for DNAJA4 Gene

DNAJA4 (DnaJ Heat Shock Protein Family (Hsp40) Member A4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA4 Gene

Genomics for DNAJA4 Gene

Regulatory Elements for DNAJA4 Gene

Promoters for DNAJA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJA4 Gene

Chromosome:
15
Start:
78,264,086 bp from pter
End:
78,282,196 bp from pter
Size:
18,111 bases
Orientation:
Plus strand

Genomic View for DNAJA4 Gene

Genes around DNAJA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA4 Gene

Proteins for DNAJA4 Gene

  • Protein details for DNAJA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW22-DNJA4_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 4
    Protein Accession:
    Q8WW22
    Secondary Accessions:
    • E9PDM9
    • Q6AW87
    • Q8N5Z4
    • Q8N7P2

    Protein attributes for DNAJA4 Gene

    Size:
    397 amino acids
    Molecular mass:
    44798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA4 Gene

Proteomics data for DNAJA4 Gene at MOPED

Post-translational modifications for DNAJA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJA4 Gene

Domains & Families for DNAJA4 Gene

Gene Families for DNAJA4 Gene

Suggested Antigen Peptide Sequences for DNAJA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW22

UniProtKB/Swiss-Prot:

DNJA4_HUMAN :
  • Contains 1 J domain.
  • Contains 1 CR-type zinc finger.
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 1 CR-type zinc finger.
genes like me logo Genes that share domains with DNAJA4: view

Function for DNAJA4 Gene

Gene Ontology (GO) - Molecular Function for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DNAJA4: view
genes like me logo Genes that share phenotypes with DNAJA4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJA4 Gene

Localization for DNAJA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA4 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJA4 Gene COMPARTMENTS Subcellular localization image for DNAJA4 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

Pathways & Interactions for DNAJA4 Gene

SuperPathways for DNAJA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with DNAJA4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJA4 Gene

Drugs & Compounds for DNAJA4 Gene

No Compound Related Data Available

Transcripts for DNAJA4 Gene

Unigene Clusters for DNAJA4 Gene

DnaJ (Hsp40) homolog, subfamily A, member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DNAJA4 Gene

GeneLoc Exon Structure for
DNAJA4
ECgene alternative splicing isoforms for
DNAJA4

Expression for DNAJA4 Gene

mRNA expression in normal human tissues for DNAJA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJA4 Gene

This gene is overexpressed in Testis (15.9) and Bone marrow mesenchymal stem cell (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJA4 Gene



SOURCE GeneReport for Unigene cluster for DNAJA4 Gene Hs.513053

genes like me logo Genes that share expression patterns with DNAJA4: view

Protein tissue co-expression partners for DNAJA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJA4 Gene

Orthologs for DNAJA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJA4 35
  • 92.49 (n)
  • 94.13 (a)
DNAJA4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA4 35
  • 91.18 (n)
  • 96.98 (a)
DNAJA4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnaja4 35
  • 90.09 (n)
  • 93.2 (a)
Dnaja4 16
Dnaja4 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJA4 35
  • 99.5 (n)
  • 99.75 (a)
DNAJA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnaja4 35
  • 90.06 (n)
  • 92.96 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJA4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA4 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA4 35
  • 76.29 (n)
  • 81.01 (a)
DNAJA4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja4.1 35
  • 70.37 (n)
  • 73.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64353 35
zebrafish
(Danio rerio)
Actinopterygii dnaja 35
  • 67.34 (n)
  • 68.27 (a)
DNAJA4 36
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10348 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005981 35
  • 60.25 (n)
  • 58.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Droj2 35
  • 62.84 (n)
  • 61.99 (a)
Droj2 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-12 35
  • 56.57 (n)
  • 51.65 (a)
dnj-12 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 36
  • 47 (a)
OneToMany
CAJ1 38
barley
(Hordeum vulgare)
Liliopsida Hv.2672 35
rice
(Oryza sativa)
Liliopsida Os02g0656500 35
  • 54.91 (n)
  • 51.27 (a)
corn
(Zea mays)
Liliopsida Zm.14501 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10384 36
  • 60 (a)
OneToMany
Species with no ortholog for DNAJA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJA4 Gene

ENSEMBL:
Gene Tree for DNAJA4 (if available)
TreeFam:
Gene Tree for DNAJA4 (if available)

Paralogs for DNAJA4 Gene

Paralogs for DNAJA4 Gene

genes like me logo Genes that share paralogs with DNAJA4: view

Variants for DNAJA4 Gene

Sequence variations from dbSNP and Humsavar for DNAJA4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_069064 -
rs6996 -- 78,281,145(+) ATCAT(A/T)TGCTG utr-variant-3-prime
rs2037347 -- 78,266,167(-) CGGAC(C/T)ACAAT intron-variant, upstream-variant-2KB
rs2139448 -- 78,281,245(-) ACAAG(C/T)AAGCA utr-variant-3-prime
rs2867933 -- 78,282,445(+) TGCAG(C/T)TGGGG downstream-variant-500B

Variation tolerance for DNAJA4 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJA4 Gene

HapMap Linkage Disequilibrium report
DNAJA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJA4 Gene

Disorders for DNAJA4 Gene

Relevant External Links for DNAJA4

Genetic Association Database (GAD)
DNAJA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJA4

No disorders were found for DNAJA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJA4 Gene

Publications for DNAJA4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for DNAJA4 Gene

Sources for DNAJA4 Gene

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