Aliases for DNAJA3 Gene
External Ids for DNAJA3 Gene
Previous HGNC Symbols for DNAJA3 Gene
Previous GeneCards Identifiers for DNAJA3 Gene
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for DNAJA3 Gene
DNAJA3 (DnaJ Heat Shock Protein Family (Hsp40) Member A3) is a Protein Coding gene. Among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Viral carcinogenesis. GO annotations related to this gene include protein kinase binding and unfolded protein binding. An important paralog of this gene is DNAJC16.
UniProtKB/Swiss-Prot for DNAJA3 Gene
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.