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Aliases for DNAJA3 Gene

Aliases for DNAJA3 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A3 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 57 3 4
  • Tumorous Imaginal Discs Protein Tid56 Homolog 3 4
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 3 2 3
  • DnaJ Protein Tid-1 3 4
  • HTID-1 3 4
  • HCA57 3 4
  • TID1 3 4

External Ids for DNAJA3 Gene

Previous HGNC Symbols for DNAJA3 Gene

  • TID1

Previous GeneCards Identifiers for DNAJA3 Gene

  • GC16P004498
  • GC16P004476
  • GC16P004415
  • GC16P004475

Summaries for DNAJA3 Gene

Entrez Gene Summary for DNAJA3 Gene

  • This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for DNAJA3 Gene

DNAJA3 (DnaJ Heat Shock Protein Family (Hsp40) Member A3) is a Protein Coding gene. Among its related pathways are Viral carcinogenesis and Apoptosis and Autophagy. GO annotations related to this gene include protein kinase binding and unfolded protein binding. An important paralog of this gene is DNAJC16.

UniProtKB/Swiss-Prot for DNAJA3 Gene

  • Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

Gene Wiki entry for DNAJA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA3 Gene

Genomics for DNAJA3 Gene

Regulatory Elements for DNAJA3 Gene

Enhancers for DNAJA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJA3 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJA3 Gene

Chromosome:
16
Start:
4,425,805 bp from pter
End:
4,456,775 bp from pter
Size:
30,971 bases
Orientation:
Plus strand

Genomic View for DNAJA3 Gene

Genes around DNAJA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA3 Gene

Proteins for DNAJA3 Gene

  • Protein details for DNAJA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EY1-DNJA3_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 3, mitochondrial
    Protein Accession:
    Q96EY1
    Secondary Accessions:
    • B2RAJ5
    • B4DI33
    • E7ES32
    • O75472
    • Q8WUJ6
    • Q8WXJ3
    • Q96D76
    • Q96IV1
    • Q9NYH8

    Protein attributes for DNAJA3 Gene

    Size:
    480 amino acids
    Molecular mass:
    52489 Da
    Quaternary structure:
    • Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity).
    SequenceCaution:
    • Sequence=AAF66245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF66245.1; Type=Frameshift; Positions=408, 411; Evidence={ECO:0000305}; Sequence=AAH12343.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJA3 Gene

    Alternative splice isoforms for DNAJA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA3 Gene

Proteomics data for DNAJA3 Gene at MOPED

Post-translational modifications for DNAJA3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DNAJA3 (DNAJA3)

No data available for DME Specific Peptides for DNAJA3 Gene

Domains & Families for DNAJA3 Gene

Gene Families for DNAJA3 Gene

Suggested Antigen Peptide Sequences for DNAJA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EY1

UniProtKB/Swiss-Prot:

DNJA3_HUMAN :
  • Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.
  • Contains 1 CR-type zinc finger.
Domain:
  • Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.
  • Contains 1 J domain.
Similarity:
  • Contains 1 CR-type zinc finger.
genes like me logo Genes that share domains with DNAJA3: view

Function for DNAJA3 Gene

Molecular function for DNAJA3 Gene

UniProtKB/Swiss-Prot Function:
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

Gene Ontology (GO) - Molecular Function for DNAJA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030695 GTPase regulator activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with DNAJA3: view
genes like me logo Genes that share phenotypes with DNAJA3: view

Animal Models for DNAJA3 Gene

MGI Knock Outs for DNAJA3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJA3 Gene

Localization for DNAJA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA3 Gene

Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJA3 Gene COMPARTMENTS Subcellular localization image for DNAJA3 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for DNAJA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005884 colocalizes_with actin filament IDA 17588722
genes like me logo Genes that share ontologies with DNAJA3: view

Pathways & Interactions for DNAJA3 Gene

genes like me logo Genes that share pathways with DNAJA3: view

Pathways by source for DNAJA3 Gene

1 Cell Signaling Technology pathway for DNAJA3 Gene
1 BioSystems pathway for DNAJA3 Gene
1 KEGG pathway for DNAJA3 Gene
1 Qiagen pathway for DNAJA3 Gene

Gene Ontology (GO) - Biological Process for DNAJA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21106534
GO:0006264 mitochondrial DNA replication IEA --
GO:0007005 mitochondrion organization IBA --
GO:0007569 cell aging IEA --
GO:0008285 negative regulation of cell proliferation IDA 11719219
genes like me logo Genes that share ontologies with DNAJA3: view

No data available for SIGNOR curated interactions for DNAJA3 Gene

Drugs & Compounds for DNAJA3 Gene

(2) Drugs for DNAJA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DNAJA3: view

Transcripts for DNAJA3 Gene

Unigene Clusters for DNAJA3 Gene

DnaJ (Hsp40) homolog, subfamily A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5: - - -
SP6: - - - - -
SP7: -
SP8:

Relevant External Links for DNAJA3 Gene

GeneLoc Exon Structure for
DNAJA3
ECgene alternative splicing isoforms for
DNAJA3

Expression for DNAJA3 Gene

mRNA expression in normal human tissues for DNAJA3 Gene

Protein differential expression in normal tissues from HIPED for DNAJA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJA3 Gene



SOURCE GeneReport for Unigene cluster for DNAJA3 Gene Hs.459779

mRNA Expression by UniProt/SwissProt for DNAJA3 Gene

Q96EY1-DNJA3_HUMAN
Tissue specificity: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
genes like me logo Genes that share expression patterns with DNAJA3: view

Protein tissue co-expression partners for DNAJA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJA3 Gene

Orthologs for DNAJA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJA3 35
  • 88.07 (n)
  • 90.16 (a)
DNAJA3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA3 35
  • 87.64 (n)
  • 88.96 (a)
DNAJA3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnaja3 35
  • 86.74 (n)
  • 87.5 (a)
Dnaja3 16
Dnaja3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJA3 35
  • 99.51 (n)
  • 99.58 (a)
DNAJA3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnaja3 35
  • 87.08 (n)
  • 87.5 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJA3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves DNAJA3 35
  • 74.85 (n)
  • 81.79 (a)
DNAJA3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja3 35
  • 67.7 (n)
  • 71.96 (a)
Str.11816 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15457 35
zebrafish
(Danio rerio)
Actinopterygii dnaja3a 35
  • 68.59 (n)
  • 70.28 (a)
dnaja3a 36
  • 66 (a)
OneToMany
dnaja3b 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12924 35
fruit fly
(Drosophila melanogaster)
Insecta CG7387 37
  • 31 (a)
l(2)tid 37
  • 51 (a)
l(2)tid 35
  • 56.02 (n)
  • 54.88 (a)
l(2)tid 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007565 35
  • 58.54 (n)
  • 58.81 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-10 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR507W 35
  • 48.96 (n)
  • 37.31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07656g 35
  • 47.52 (n)
  • 37.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDJ1 35
  • 46.77 (n)
  • 36.32 (a)
MDJ1 36
  • 28 (a)
OneToOne
MDJ1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GFA2 35
  • 48.94 (n)
  • 39.67 (a)
rice
(Oryza sativa)
Liliopsida Os12g0168400 35
  • 49.7 (n)
  • 42.81 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11768 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05196 35
  • 49.37 (n)
  • 38.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mdj1 35
  • 43.24 (n)
  • 37.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4105 36
  • 50 (a)
OneToOne
Species with no ortholog for DNAJA3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJA3 Gene

ENSEMBL:
Gene Tree for DNAJA3 (if available)
TreeFam:
Gene Tree for DNAJA3 (if available)

Paralogs for DNAJA3 Gene

Paralogs for DNAJA3 Gene

genes like me logo Genes that share paralogs with DNAJA3: view

Variants for DNAJA3 Gene

Sequence variations from dbSNP and Humsavar for DNAJA3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_027965 -
rs9745577 -- 4,432,751(+) gagtc(A/G)cttga intron-variant
rs9926114 -- 4,428,321(+) GCTCA(C/G)TTCAG intron-variant
rs61263579 -- 4,434,812(+) TATGC(C/T)AGTCT intron-variant
rs9926391 -- 4,451,478(+) CCggc(C/T)gggcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJA3 Gene

Variant ID Type Subtype PubMed ID
nsv905224 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
esv23732 CNV Gain 19812545
nsv833132 CNV Loss 17160897

Variation tolerance for DNAJA3 Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJA3 Gene

HapMap Linkage Disequilibrium report
DNAJA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA3 Gene

Disorders for DNAJA3 Gene

Relevant External Links for DNAJA3

Genetic Association Database (GAD)
DNAJA3
Human Genome Epidemiology (HuGE) Navigator
DNAJA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJA3

No disorders were found for DNAJA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJA3 Gene

Publications for DNAJA3 Gene

  1. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. (PMID: 9683573) Schilling B. … Munger K. (Virology 1998) 2 3 4 23 67
  2. Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer. (PMID: 19935715) Ahn B.Y. … Kim S.W. (Oncogene 2010) 3 23
  3. Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma. (PMID: 19681071) Chen C.Y. … Lo J.F. (J. Pathol. 2009) 3 23
  4. Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate. (PMID: 16531398) Lu B. … Suzuki C.K. (J. Biol. Chem. 2006) 3 23
  5. Human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells. (PMID: 15753086) Liu H.Y. … Meakin S.O. (J. Biol. Chem. 2005) 3 23

Products for DNAJA3 Gene

Sources for DNAJA3 Gene

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