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DNAJA3 Gene

protein-coding   GIFtS: 65
GCID: GC16P004475

DnaJ (Hsp40) Homolog, Subfamily A, Member 3


(Previous symbol: TID1)
  See DNAJA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily A, Member 31 2     HCA572 3
TID11 2 3 5     DnaJ Homolog Subfamily A Member 3, Mitochondrial2
DnaJ Protein Tid-12 3     hTID-12
Hepatocellular Carcinoma-Associated Antigen 572 3     hTid-13
Tumorous Imaginal Discs Protein Tid56 Homolog2 3     

External Ids:    HGNC: 118081   Entrez Gene: 90932   Ensembl: ENSG000001034237   OMIM: 6083825   UniProtKB: Q96EY13   

Export aliases for DNAJA3 gene to outside databases

Previous GC identifers: GC16P004498 GC16P004476 GC16P004415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJA3 Gene:
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of
Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The
encoded protein is localized to mitochondria and mediates several cellular processes including proliferation,
survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression
through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug
2011)

GeneCards Summary for DNAJA3 Gene:
DNAJA3 (DnaJ (Hsp40) homolog, subfamily A, member 3) is a protein-coding gene. Diseases associated with DNAJA3 include hepatocellular carcinoma. GO annotations related to this gene include unfolded protein binding and protein kinase binding.

UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect
cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1
increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2
suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in
neuromuscular junction development as an effector of the MUSK signaling pathway

Gene Wiki entry for DNAJA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  NT_187608.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJA3 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJA3 promoter sequence
   Search Chromatin IP Primers for DNAJA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

DNAJA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJA3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004475:  view genomic region     (about GC identifiers)

Start:
4,475,806 bp from pter      End:
4,506,776 bp from pter
Size:
30,971 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1 (See protein sequence)
Recommended Name: DnaJ homolog subfamily A member 3, mitochondrial precursor  
Size: 480 amino acids; 52489 Da
Subunit: Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1
(RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity)
Sequence caution: Sequence=AAF66245.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF66245.1; Type=Frameshift; Positions=408, 411; Sequence=AAH12343.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for DNAJA3:
2CTT (3D)        2DN9 (3D)    
Secondary accessions: B2RAJ5 O75472 Q8WUJ6 Q8WXJ3 Q96D76 Q96IV1 Q9NYH8
Alternative splicing: 2 isoforms:  Q96EY1-1   Q96EY1-2   

Explore the universe of human proteins at neXtProt for DNAJA3: NX_Q96EY1

Explore proteomics data for DNAJA3 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated (By similarity)1
  • Ubiquitination2 at Lys152
  • Modification sites at PhosphoSitePlus

  • See DNAJA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128582.1  NP_001273445.1  NP_005138.3  

    ENSEMBL proteins: 
     ENSP00000262375   ENSP00000347445   ENSP00000460358   ENSP00000458868   ENSP00000459098  
     ENSP00000459088   ENSP00000393970  

    DNAJA3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DNAJA3

     
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    antibodies-online proteins for DNAJA3 (3 products) 

     
    antibodies-online peptides for DNAJA3

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    antibodies-online antibodies for DNAJA3 (42 products) 

    DNAJA3 Assay Products:

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    Cloud-Clone Corp. CLIAs for DNAJA3
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    antibodies-online kits for DNAJA3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    Selected InterPro protein domains (see all 6):
     IPR008971 HSP40/DnaJ_pept-bd
     IPR012724 DnaJ
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q96EY1

    ProtoNet protein and cluster: Q96EY1

    2 Blocks protein domains:
    IPB001305 DnaJ central domain (CXXCXGXG)
    IPB003095 DnaJ protein family signature


    UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
    Domain: Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2,
    is J domain-dependent
    Similarity: Contains 1 CR-type zinc finger
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJA3_HUMAN, Q96EY1
    Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect
    cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1
    increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2
    suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in
    neuromuscular junction development as an effector of the MUSK signaling pathway

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005133interferon-gamma receptor binding IDA11679576
    GO:0005515protein binding IPI10411904
    GO:0005524ATP binding IEA--
    GO:0008134transcription factor binding IPI16531398
         
    Find genes that share ontologies with DNAJA3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DNAJA3:
     Decreased cell number, increas 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dnaja3):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  mortality/aging  muscle  normal 

    Find genes that share phenotypes with DNAJA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dnaja3tm1.2Jdl for DNAJA3

       genOway: Develop your customized and physiologically relevant rodent model for DNAJA3

    miRNA
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    miRTarBase miRNAs that target DNAJA3:
    hsa-mir-193b-3p (MIRT041303), hsa-mir-92a-3p (MIRT049135), hsa-mir-484 (MIRT042039), hsa-mir-99a-5p (MIRT048688), hsa-mir-26b-5p (MIRT029308), hsa-mir-328-3p (MIRT043778), hsa-mir-149-5p (MIRT045410), hsa-mir-550a-3p (MIRT040500)

    Block miRNA regulation of human, mouse, rat DNAJA3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DNAJA3:
    hsa-miR-579 hsa-miR-320e hsa-miR-129-5p hsa-miR-32* hsa-miR-1301 hsa-miR-507 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJA3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJA3 (NM_005147)
    Sino Biological Human cDNA Clone for DNAJA3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA3
    Addgene plasmids for DNAJA3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJA3_HUMAN, Q96EY1: Mitochondrion matrix. Cytoplasm, cytosol (By similarity). Cell junction, synapse,
    postsynaptic cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the postsynaptic cell
    membrane of the neuromuscular junction through interaction with MUSK (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    plasma membrane4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11679576
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IDA10411904
    GO:0005829cytosol IMP16531398

    Find genes that share ontologies with DNAJA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Transformation by HTLV1
    Cellular Transformation by HTLV10.31
    2Viral carcinogenesis
    Viral carcinogenesis
    3Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    4Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with DNAJA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DNAJA3
        Cellular Transformation by HTLV1

    1 Cell Signaling Technology (CST) Pathway for DNAJA3
        Apoptosis and Autophagy

    1 BioSystems Pathway for DNAJA3
        Neurotrophic factor-mediated Trk receptor signaling



    1 Kegg Pathway  (Kegg details for DNAJA3):
        Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA3: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJA3 (Q96EY11, 2, 3 ENSP000002623754) via UniProtKB, MINT, STRING, and/or I2D (see all 362)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-8079030 I2D: score=1 
    ENSG00000215328P081072, 3MINT-8079030 I2D: score=1 
    ENSG00000224501P081072, 3MINT-8079030 I2D: score=1 
    ENSG00000231555P081072, 3MINT-8079030 I2D: score=1 
    ENSG00000232804P081072, 3MINT-8079030 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006264mitochondrial DNA replication IEA--
    GO:0006457protein folding IEA--
    GO:0006469negative regulation of protein kinase activity IDA15601829
    GO:0006915apoptotic process ----

    Find genes that share ontologies with DNAJA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJA3 (DNJA3)

    2 Novoseek inferred chemical compound relationships for DNAJA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 39 1 15156195 (1)
    tyrosine 16.7 6 15753086 (5)



    Find genes that share compounds with DNAJA3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJA3 gene (3 alternative transcripts): 
    NM_001135110.2  NM_001286516.1  NM_005147.5  

    Unigene Cluster for DNAJA3:

    DnaJ (Hsp40) homolog, subfamily A, member 3
    Hs.459779  [show with all ESTs]
    Unigene Representative Sequence: NM_005147
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262375(uc002cwk.3 uc002cwl.3 uc010uxk.2) ENST00000355296
    ENST00000570857 ENST00000575106 ENST00000576911 ENST00000572974 ENST00000574895
    ENST00000573120 ENST00000572139 ENST00000572009 ENST00000577083 ENST00000576180
    ENST00000574393 ENST00000431375
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    hsa-miR-579 hsa-miR-320e hsa-miR-129-5p hsa-miR-32* hsa-miR-1301 hsa-miR-507 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA3 3' UTR sequence
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    Addgene plasmids for DNAJA3 
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      QuantiFast Probe-based Assays in human, mouse, rat DNAJA3

    Additional mRNA sequence: 

    AB209923.1 AF061749.1 AF244136.1 AF411044.1 AK001333.1 AK127660.1 AK223105.1 AK295391.1 
    AK314218.1 BC007225.1 BC011855.2 BC012343.1 BC014062.2 BC020248.1 BC030145.2 BC032100.2 

    15 DOTS entries:

    DT.454951  DT.95345796  DT.100815071  DT.92020569  DT.101984881  DT.91773123  DT.100815070  DT.101964994 
    DT.100709737  DT.91773126  DT.95237340  DT.95349553  DT.97847291  DT.100663108  DT.92058345 

    Selected AceView cDNA sequences (see all 276):

    BU157368 BQ673519 AI083571 AW247135 BF439350 BM991076 AV647708 AI084429 
    AI586998 BU163980 BU539512 BM550217 BI772176 AW771375 AA864601 CB152382 
    BM977415 BF111725 BM910814 BX113086 BU557960 CK823207 AK127660 AK001333 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:              -     -                                                                             -                 -                     
    SP2:              -     -                                                                             -           -     -                     
    SP3:                    -                                                                                                                     
    SP4:                                                                                                                                          
    SP5:              -     -     -                                                                                                               


    ECgene alternative splicing isoforms for DNAJA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTCAGGA
    DNAJA3 Expression
    About this image

    DNAJA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459779

    UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
    Tissue specificity: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also
    expressed in keratinocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA3: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DNAJA3
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA3
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJA3
    QuantiFast Probe-based Assays in human, mouse, rat DNAJA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJA3 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnaja31 , 5 DnaJ (Hsp40) homolog, subfamily A, member 31, 5 86.74(n)1
    87.5(a)1
      16 (2.46 cM)5
    839451  NM_023646.41  NP_076135.31 
     46399895 
    chicken
    (Gallus gallus)
    Aves DNAJA31 DnaJ (Hsp40) homolog, subfamily A, member 3 74.85(n)
    81.79(a)
      416671  XM_414967.4  XP_414967.3 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJA36
    DnaJ (Hsp40) homolog, subfamily A, member 3
    81(a)
    1 ↔ 1
    AAWZ02039885(105-7216)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154572 Xenopus laevis transcribed sequence with weak similarity more 72.71(n)    CF548066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnaja3a2 DnaJ (Hsp40) homolog, subfamily A, member 3A 75.47(n)   335894  BC047809.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)tid1 , 3 lethal (2) tumorous imaginal discs1 51(a)
    (best of 2)3
    56.02(n)1
    54.88(a)1
      59F63
    488441  NM_206210.21  NP_995932.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-106
    Protein DNJ-10, isoform b
    37(a)
    1 ↔ 1
    III(8631165-8633571) WBGene00001028
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDJ1(YFL016C)4
    MDJ11
    Co-chaperone that stimulates the ATPase activity of more4
    MDJ11
    46.77(n)1
    36.32(a)1
      6(106236-104701)4
    8505301, 4  NP_116638.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GFA21 GFA2 48.94(n)
    39.67(a)
      834854  NM_124177.3  NP_568690.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01684001 Os12g0168400 49.7(n)
    42.81(a)
      4351608  NM_001072786.1  NP_001066254.1 


    ENSEMBL Gene Tree for DNAJA3 (if available)
    TreeFam Gene Tree for DNAJA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJA3 gene
    16 SIMAP similar genes for DNAJA3 using alignment to 7 protein entries:     DNJA3_HUMAN (see all proteins):
    DNAJB5    DNAJB6    DNAJB2    DNAJC5B    DNAJA4    DNAJC1
    DNAJA2    LRTOMT    NSD1    CNOT2    TGFBR3    ZNF23
    DNAJB9    DNAJC17    DNAJC24    ZCSL3

    Find genes that share paralogs with DNAJA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJA3 (see all 818)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713885781,2
    C,F--4410208(+) GAAAAT/CTGAAA 2 -- us2k13Minor allele frequency- C:0.05NA 124
    rs1820310591,2
    --4410328(+) TGGCGC/TGATCT 2 -- us2k10--------
    rs620391761,2
    F--4410337(+) CTCGGG/CTCACT 2 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1919165901,2
    --4410511(+) CCGCCC/TGCCTC 2 -- us2k10--------
    rs1396491101,2
    C--4410624(+) CTGGAC/GTGCAG 2 -- us2k10--------
    rs1180635771,2
    C--4410729(+) TACCAT/CGACTG 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1452004421,2
    --4410792(+) GGTCTA/GGCACT 2 -- us2k10--------
    rs65005991,2
    C,F,A--4410818(+) CGCCGC/GCACCT 2 -- us2k112Minor allele frequency- G:0.26NA WA CSA EA 375
    rs1158985221,2
    F--4410948(+) CTTAAG/TTTCAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1811737501,2
    --4411115(+) TGTGAC/TAGCAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJA3 (4475806 - 4506776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DNAJA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2586n71CNV Loss21882294
    nsv833132CNV Loss17160897
    nsv905224CNV Loss21882294
    esv23732CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJA3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608382    OMIM disorders: --

    1 disease for DNAJA3:    
    About MalaCards
    hepatocellular carcinoma


    Find genes that share disorders with DNAJA3           About GenesLikeMe

    4 Novoseek inferred disease relationships for DNAJA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.7 25 15520177 (4), 15156195 (3), 16204048 (2), 9683573 (2) (see all 9)
    shock 9.78 4 11719219 (1), 15520177 (1)
    necrosis 0 1 15156195 (1)
    cancer 0 4 16204048 (2), 19935715 (2)

    Genetic Association Database (GAD): DNAJA3
    Human Genome Epidemiology (HuGE) Navigator: DNAJA3 (2 documents)

    Export disorders for DNAJA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJA3 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with DNAJA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. (PubMed id 9683573)1, 2, 3, 9 Schilling B.... Munger K. (Virology 1998)
    2. hTid-1, a human DnaJ protein, modulates the interferon signaling pathway. (PubMed id 11679576)1, 2, 9 Sarkar S....Pestka S. (J. Biol. Chem. 2001)
    3. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. (PubMed id 10411904)1, 2, 9 Syken J.... Muenger K. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1, 2 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2 Wang Y....Chen W.-F. (J. Immunol. 2002)
    10. Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70. (PubMed id 11719219)1, 9 Cheng H....Cheng-Mayer C. (Curr. Biol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9093 HGNC: 11808 AceView: DNAJA3 Ensembl:ENSG00000103423 euGenes: HUgn9093
    ECgene: DNAJA3 Kegg: 9093 H-InvDB: DNAJA3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNAJA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNAJA3 gene:
    Search GeneIP for patents involving DNAJA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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