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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJA3 Gene

protein-coding   GIFtS: 61
GCID: GC16P004475

DnaJ (Hsp40) homolog, subfamily A, member 3


(Previous symbol: TID1)
 Explore 18 diseases affiliated with
DNAJA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DNAJA3    

Aliases
for DNAJA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DnaJ (Hsp40) Homolog, Subfamily A, Member 31 2     Tumorous Imaginal Discs Protein Tid56 Homolog2 3
TID11 2 3 5     HCA572 3
HTid-11     DnaJ Homolog Subfamily A Member 3, Mitochondrial2
DnaJ Protein Tid-12 3     HTID-11
Hepatocellular Carcinoma-Associated Antigen 572 3     

External Ids:    HGNC: 118081   Entrez Gene: 90932   Ensembl: ENSG000001034237   OMIM: 6083825   UniProtKB: Q96EY13   

Export aliases for DNAJA3 gene to outside databases

Previous GC identifers: GC16P004498 GC16P004476 GC16P004415


Summaries
for DNAJA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNAJA3:
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70
chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded
protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and
apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through
interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect
cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases
apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses
apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular
junction development as an effector of the MUSK signaling pathway

Gene Wiki entry for DNAJA3


Genomic Views
for DNAJA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJA3 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNAJA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

DNAJA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJA3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004475:  view genomic region     (about GC identifiers)

Start:
 4,475,806 bp from pter      End:
 4,506,776 bp from pter
Size:
 30,971 bases      Orientation:
 plus strand

Proteins
for DNAJA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1 (See protein sequence)
Recommended Name: DnaJ homolog subfamily A member 3, mitochondrial precursor  
Size: 480 amino acids; 52489 Da
Subunit: Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1).
Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity)
Subcellular location: Mitochondrion matrix. Cytoplasm, cytosol (By similarity). Cell junction, synapse, postsynaptic
cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the postsynaptic cell membrane of the
neuromuscular junction through interaction with MUSK (By similarity)
Sequence caution: Sequence=AAF66245.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF66245.1; Type=Frameshift; Positions=408, 411; Sequence=AAH12343.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for DNAJA3:
2CTT (3D)        2DN9 (3D)    
Secondary accessions: B2RAJ5 O75472 Q8WUJ6 Q8WXJ3 Q96D76 Q96IV1 Q9NYH8
Alternative splicing: 2 isoforms:  Q96EY1-1   Q96EY1-2   

Explore the universe of human proteins at neXtProt for DNAJA3: NX_Q96EY1

Post-translational modifications:

  • Tyrosine phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96EY1

    • DNAJA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128582.1  NP_005138.3  

    ENSEMBL proteins: 
     ENSP00000262375   ENSP00000347445   ENSP00000460358   ENSP00000458868   ENSP00000459098  
     ENSP00000459088   ENSP00000393970  

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    Uscn Proteins for DNAJA3

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11679576
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IDA10411904
    GO:0005829cytosol IMP16531398


    DNAJA3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DNAJA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNAJA3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008971 HSP40/DnaJ_pept-bd
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS
     IPR001305 HSP_DnaJ_Cys-rich_dom

    Graphical View of Domain Structure for InterPro Entry Q96EY1

    ProtoNet protein and cluster: Q96EY1

    2 Blocks protein families:
    IPB001305 DnaJ central domain (CXXCXGXG)
    IPB003095 DnaJ protein family signature


    UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
    Domain: Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J
    domain-dependent
    Similarity: Contains 1 CR-type zinc finger
    Similarity: Contains 1 J domain


    Function
    for DNAJA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
    Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect
    cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases
    apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses
    apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular
    junction development as an effector of the MUSK signaling pathway

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    Inhib. RNA
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    Gene Editing
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005133interferon-gamma receptor binding IDA11679576
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008134transcription factor binding IPI--


    DNAJA3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DNAJA3:
     Decreased cell number, increas 

    Animal Models:
         Mouse knock-out Dnaja3tm1.2Jdl for DNAJA3
         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dnaja3):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     homeostasis/metabolism  mortality/aging  muscle  normal 

    DNAJA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DNAJA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Neurotrophic factor-mediated Trk receptor signaling
    		Neurotrophic factor-mediated Trk receptor signaling1.00
    3RIP-mediated NFkB activation via DAI
    		Cellular Transformation by HTLV10.18

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DNAJA3
        Cellular Transformation by HTLV1

    1 Cell Signaling Technology (CST) Pathway for DNAJA3
        Apoptosis and Autophagy

    1 BioSystems Pathway for DNAJA3 
        Neurotrophic factor-mediated Trk receptor signaling



    DNAJA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/316 Interacting proteins for DNAJA3 (Q96EY11, 2, 3 ENSP000002623754) via UniProtKB, MINT, STRING, and/or I2D (see all 316)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1AP194382, 3, ENSP000001627494MINT-49350 I2D: score=2 STRING: ENSP00000162749
    HSPA1BP081072, 3MINT-8079030 I2D: score=1 
    METP085811, 3, ENSP000003172724EBI-3952284,EBI-1039152 I2D: score=1 STRING: ENSP00000317272
    SMAD9O151982, 3MINT-62102 I2D: score=3 
    MAP3K1Q132332, 3MINT-48330 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006264mitochondrial DNA replication IEA--
    GO:0006457protein folding IEA--
    GO:0006469negative regulation of protein kinase activity IDA15601829
    GO:0006915apoptotic process ----


    DNAJA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNAJA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNAJA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DNAJA3
    2 Novoseek chemical compound relationships for DNAJA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 39 1 15156195 (1)
    tyrosine 16.7 6 15753086 (5)

    Search CenterWatch for drugs/clinical trials and news about DNAJA3 / DNJA3 

    Transcripts
    for DNAJA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNAJA3 gene (2 alternative transcripts): 
    NM_001135110.2  NM_005147.5  

    Unigene Cluster for DNAJA3:

    DnaJ (Hsp40) homolog, subfamily A, member 3
    Hs.744096  [show with all ESTs]
    Unigene Representative Sequence: NM_005147
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262375(uc002cwk.3 uc002cwl.3 uc010uxk.2) ENST00000355296
    ENST00000570857 ENST00000575106 ENST00000576911 ENST00000572974 ENST00000574895
    ENST00000573120 ENST00000572139 ENST00000572009 ENST00000577083 ENST00000576180
    ENST00000574393 ENST00000431375

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    hsa-miR-579 hsa-miR-320e hsa-miR-129-5p hsa-miR-32* hsa-miR-1301 hsa-miR-507 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmid: DNAJA3 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB209923.1 AF061749.1 AF244136.1 AF411044.1 AK001333.1 AK127660.1 AK223105.1 AK295391.1 
    AK314218.1 BC007225.1 BC011855.2 BC012343.1 BC014062.2 BC020248.1 BC030145.2 BC032100.2 

    15 DOTS entries:

    DT.454951  DT.95345796  DT.100815071  DT.92020569  DT.101984881  DT.91773123  DT.100815070  DT.101964994 
    DT.100709737  DT.95237340  DT.95349553  DT.97847291  DT.100663108  DT.91773126  DT.92058345 

    24/276 AceView cDNA sequences (see all 276):

    BQ898563 AA291509 BM977415 BM910814 AL697666 BU163980 AA757327 AV647708 
    BM795314 AI753257 BU557960 BF439350 BU145833 BM550217 BQ101244 BQ673519 
    AI084429 AA315765 CF124961 BG254837 AW771375 BM910858 AK001333 AK127660 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:              -     -                                                                             -                 -                     
    SP2:              -     -                                                                             -           -     -                     
    SP3:                    -                                                                                                                     
    SP4:                                                                                                                                          
    SP5:              -     -     -                                                                                                               


    ECgene alternative splicing isoforms for DNAJA3

    Expression
    for DNAJA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTTCAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DNAJA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJA3

    SOURCE GeneReport for Unigene cluster: Hs.744096

    UniProtKB/Swiss-Prot: DNJA3_HUMAN, Q96EY1
    Tissue specificity: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in
    keratinocytes

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    In Situ
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    Orthologs
    for DNAJA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DNAJA3 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DNAJA31 DnaJ (Hsp40) homolog, subfamily A, member 3 75.4(n)
    82.62(a)    		   416671  XM_414967.3  XP_414967.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DNAJA36
    		 --
    		 80(a)
    		 1 ↔ 1
    		 AAWZ02039885(105-5058)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.154572 Xenopus laevis transcribed sequence with weak similarity more 72.71(n)    CF548066.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dnaja3a2 DnaJ (Hsp40) homolog, subfamily A, member 3A 75.47(n)   335894  BC047809.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta l(2)tid1 , 3 lethal (2) tumorous imaginal discs1 51(a)
    (best of 2)3
    55.35(n)1
    53.63(a)1    		   59F63
    488441  NM_206210.21  NP_995932.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea dnj-101 Protein DNJ-10 49.53(n)
    43.96(a)    		   176211  NM_066501.2  NP_498902.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GFA26
    ATJ16
    (see all 5)    		 chaperone protein dnaJ 1
    (see all 5)    		 28(a)
    27(a)
    (see all 5)    		 1 ↔ many
    1 ↔ many
    (see all 5)    		 5(19466011-19469902)
    1(9854546-9860158)
    rice
    (Oryza sativa)    		 Liliopsida Os12g01684001 hypothetical protein 50.1(n)
    43.07(a)    		   4351608  NM_001072786.1  NP_001066254.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria dnaJ6
    cbpA6
    		 chaperone Hsp40, co-chaperone with DnaK
    curved DNA-binding protein, DnaJ homologue that fu...
    		 31(a)
    27(a)
    		 1 ↔ many
    1 ↔ many
    		 Chromosome(14168-15298)
    Chromosome(1062078-1062998)


    ENSEMBL Gene Tree for DNAJA3 (if available)
    TreeFam Gene Tree for DNAJA3 (if available) 

    Paralogs
    for DNAJA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DNAJA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/643 NCBI SNPs in DNAJA3 are shown (see all 643)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs713885781,2
    		C,F,--4441128(+) GAAAAT/CTGAAA 2 -- us2k13Minor allele frequency- C:0.05NA 124
    rs620391761,2
    		--4441257(+) CTCGGG/CTCACT 2 -- us2k11Minor allele frequency- C:0.50NA 2
    rs121649981,2
    		--4441347(+) cgcccA/Ggctaa 2 -- us2k10--------
    rs790737001,2
    		C,--4442344(+) AGGAGC/TTCAAG 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1136572391,2
    		C,F,--4442475(+) GAACCC/TGGGAG 2 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs171370181,2
    		C,F,H,--4442879(+) ACACCC/GATTGG 2 -- us2k111Minor allele frequency- G:0.03NA NS EA CSA WA 804
    rs768969021,2
    		F,--4443006(+) ACGGTG/ACGCCT 2 -- us2k11Minor allele frequency- A:0.07WA 118
    rs601628301,2
    		F,--4443435(+) GGATGC/TACAAT 2 -- int11Minor allele frequency- T:0.08WA 118
    rs171370191,2
    		C,F,--4443870(+) GCACAG/ATTAAC 2 -- int15Minor allele frequency- A:0.02NA 264
    rs740053211,2
    		C,F,--4444019(+) AGATAC/GTGAGG 2 -- int15Minor allele frequency- G:0.04WA NA CSA 244

    HapMap Linkage Disequilibrium report for DNAJA3 (4475806 - 4506776 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DNAJA3
         1 CNV: 72438

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    Disorders / Diseases
    for DNAJA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNAJA3 for disorders           About GeneDecksing

    OMIM gene information: 608382    OMIM disorders: --

    18 diseases for DNAJA3:    About MalaCards
    hepatocellular carcinoma    human t-cell leukemia virus type 1    carcinoma    renal cell carcinoma
    squamous cell carcinoma    t-cell leukemia    hepatitis b    polyposis
    esophageal cancer    esophagitis    colorectal cancer    leukemia
    breast cancer    ataxia    hepatitis    pneumonia
    tuberculosis    mycobacterium tuberculosis

    4 Novoseek disease relationships for DNAJA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.7 25 15520177 (4), 15156195 (3), 16204048 (2), 9683573 (2) (see all 9)
    shock 9.78 4 11719219 (1), 15520177 (1)
    necrosis 0 1 15156195 (1)
    cancer 0 4 16204048 (2), 19935715 (2)

    Human Genome Epidemiology (HuGE) Navigator: DNAJA3 (2 documents)

    Export disorders for DNAJA3 gene to outside databases

    Publications
    for DNAJA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJA3 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with DNAJA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. (PubMed id 9683573)1, 2, 3, 9 Schilling B.... Munger K. (1998)
    2. hTid-1, a human DnaJ protein, modulates the interferon signaling pathway. (PubMed id 11679576)1, 2, 9 Sarkar S....Pestka S. (2001)
    3. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. (PubMed id 10411904)1, 2, 9 Syken J.... Muenger K. (1999)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2 Wang Y....Chen W.-F. (2002)
    7. Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70. (PubMed id 11719219)1, 9 Cheng H....Cheng-Mayer C. (2001)
    8. Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells. (PubMed id 15520177)1, 9 Kim S.W....Lee J.D. (2004)
    9. Tid1 functions as a tumour suppressor in head and nec k squamous cell carcinoma. (PubMed id 19681071)1, 9 Chen C.Y....Lo J.F. (2009)
    10. Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate. (PubMed id 16531398)1, 9 Lu B....Suzuki C.K. (2006)

    External Searches for DNAJA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DNAJA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9093 HGNC: 11808 AceView: DNAJA3 Ensembl:ENSG00000103423 euGenes: HUgn9093
    ECgene: DNAJA3 H-InvDB: DNAJA3

    Other Databases showing DNAJA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNAJA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNAJA3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DNAJA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNAJA3 gene:
    Search GeneIP for patents involving DNAJA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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