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Aliases for DNAJA2 Gene

Aliases for DNAJA2 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A2 2 3 5
  • Cell Cycle Progression Restoration Gene 3 Protein 3 4
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 2 2 3
  • Renal Carcinoma Antigen NY-REN-14 3 4
  • HIRA-Interacting Protein 4 3 4
  • HIRIP4 3 4
  • DNJ3 3 4
  • CPR3 3 4
  • DJ3 3 4
  • Cell Cycle Progression 3 Protein 3
  • HIRA Interacting Protein 4 3
  • PRO3015 3
  • DJA2 3
  • DNAJ 3
  • RDJ2 3

External Ids for DNAJA2 Gene

Previous GeneCards Identifiers for DNAJA2 Gene

  • GC16M037401
  • GC16M046730
  • GC16M046771
  • GC16M045547
  • GC16M032879

Summaries for DNAJA2 Gene

Entrez Gene Summary for DNAJA2 Gene

  • The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNAJA2 Gene

DNAJA2 (DnaJ Heat Shock Protein Family (Hsp40) Member A2) is a Protein Coding gene. Diseases associated with DNAJA2 include subacute bacterial endocarditis and adult syndrome. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA4.

UniProtKB/Swiss-Prot for DNAJA2 Gene

  • Co-chaperone of Hsc70.

Gene Wiki entry for DNAJA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA2 Gene

Genomics for DNAJA2 Gene

Regulatory Elements for DNAJA2 Gene

Promoters for DNAJA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJA2 Gene

Chromosome:
16
Start:
46,955,362 bp from pter
End:
46,973,788 bp from pter
Size:
18,427 bases
Orientation:
Minus strand

Genomic View for DNAJA2 Gene

Genes around DNAJA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA2 Gene

Proteins for DNAJA2 Gene

  • Protein details for DNAJA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60884-DNJA2_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 2
    Protein Accession:
    O60884
    Secondary Accessions:
    • B2R7L7
    • O14711

    Protein attributes for DNAJA2 Gene

    Size:
    412 amino acids
    Molecular mass:
    45746 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJA2 Gene

Proteomics data for DNAJA2 Gene at MOPED

Post-translational modifications for DNAJA2 Gene

  • Ubiquitination at Lys 25, Lys 131, Lys 134, Lys 152, Lys 199, and Lys 326
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJA2 Gene

Domains & Families for DNAJA2 Gene

Gene Families for DNAJA2 Gene

Suggested Antigen Peptide Sequences for DNAJA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60884

UniProtKB/Swiss-Prot:

DNJA2_HUMAN :
  • Contains 1 J domain.
  • Contains 1 CR-type zinc finger.
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 1 CR-type zinc finger.
genes like me logo Genes that share domains with DNAJA2: view

Function for DNAJA2 Gene

Molecular function for DNAJA2 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone of Hsc70.

Gene Ontology (GO) - Molecular Function for DNAJA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DNAJA2: view
genes like me logo Genes that share phenotypes with DNAJA2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJA2 Gene

Localization for DNAJA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA2 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJA2 Gene COMPARTMENTS Subcellular localization image for DNAJA2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
cytoskeleton 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DNAJA2 Gene

Pathways & Interactions for DNAJA2 Gene

genes like me logo Genes that share pathways with DNAJA2: view

Pathways by source for DNAJA2 Gene

1 KEGG pathway for DNAJA2 Gene

Gene Ontology (GO) - Biological Process for DNAJA2 Gene

None

No data available for SIGNOR curated interactions for DNAJA2 Gene

Drugs & Compounds for DNAJA2 Gene

(2) Drugs for DNAJA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for DNAJA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DNAJA2: view

Transcripts for DNAJA2 Gene

Unigene Clusters for DNAJA2 Gene

DnaJ (Hsp40) homolog, subfamily A, member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3: - - - -
SP4:
SP5:
SP6:

Relevant External Links for DNAJA2 Gene

GeneLoc Exon Structure for
DNAJA2
ECgene alternative splicing isoforms for
DNAJA2

Expression for DNAJA2 Gene

mRNA expression in normal human tissues for DNAJA2 Gene

Protein differential expression in normal tissues from HIPED for DNAJA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJA2 Gene



SOURCE GeneReport for Unigene cluster for DNAJA2 Gene Hs.368078

genes like me logo Genes that share expression patterns with DNAJA2: view

Protein tissue co-expression partners for DNAJA2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJA2 Gene

Orthologs for DNAJA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJA2 35
  • 93.93 (n)
  • 99.51 (a)
DNAJA2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA2 35
  • 95.15 (n)
  • 99.76 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dnaja2 35
  • 92.64 (n)
  • 99.51 (a)
Dnaja2 16
Dnaja2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJA2 35
  • 99.84 (n)
  • 100 (a)
DNAJA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnaja2 35
  • 92.39 (n)
  • 99.51 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJA2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA2 35
  • 85.64 (n)
  • 94.16 (a)
DNAJA2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA2 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja2 35
  • 81.54 (n)
  • 92.2 (a)
Str.6675 35
African clawed frog
(Xenopus laevis)
Amphibia dnaja2-prov 35
zebrafish
(Danio rerio)
Actinopterygii dnaja2 35
  • 74.45 (n)
  • 85.16 (a)
Dr.26979 35
dnaja2 36
  • 86 (a)
OneToMany
dnaja2l 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta DnaJ-H 37
  • 38 (a)
DnaJ-H 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-19 35
  • 55.72 (n)
  • 51.99 (a)
dnj-19 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL257C 35
  • 53.57 (n)
  • 49.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03333g 35
  • 56.26 (n)
  • 49.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 35
  • 56.75 (n)
  • 50.51 (a)
YDJ1 36
  • 49 (a)
OneToMany
YDJ1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons J2 35
  • 56.2 (n)
  • 52.66 (a)
soybean
(Glycine max)
eudicotyledons Gma.1634 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8056 35
barley
(Hordeum vulgare)
Liliopsida Hv.315 35
rice
(Oryza sativa)
Liliopsida Os03g0787300 35
  • 55.43 (n)
  • 55.07 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.18956 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07414 35
  • 52.11 (n)
  • 48.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mas5 35
  • 53.48 (n)
  • 48.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for DNAJA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJA2 Gene

ENSEMBL:
Gene Tree for DNAJA2 (if available)
TreeFam:
Gene Tree for DNAJA2 (if available)

Paralogs for DNAJA2 Gene

Paralogs for DNAJA2 Gene

(11) SIMAP similar genes for DNAJA2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DNAJA2 Gene

genes like me logo Genes that share paralogs with DNAJA2: view

Variants for DNAJA2 Gene

Sequence variations from dbSNP and Humsavar for DNAJA2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12836 -- 46,956,869(+) TTAAA(A/T)TATAC utr-variant-3-prime
rs1420233 -- 46,959,980(-) ACCTA(G/T)TCCAT intron-variant
rs1362406 -- 46,962,645(-) TAGCT(A/C)CTTCC intron-variant
rs1045650 -- 46,968,114(-) ACTTA(A/G/T)CAAGA reference, missense
rs1065332 -- 46,971,434(-) TTTTT(G/T)GTGGG reference, missense

Variation tolerance for DNAJA2 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJA2 Gene

HapMap Linkage Disequilibrium report
DNAJA2
Human Gene Mutation Database (HGMD)
DNAJA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJA2 Gene

Disorders for DNAJA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAJA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subacute bacterial endocarditis
  • endocarditis lenta
adult syndrome
  • acro-dermato-ungual-lacrimal-tooth syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJA2
genes like me logo Genes that share disorders with DNAJA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJA2 Gene

Publications for DNAJA2 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  3. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PMID: 9710638) Lorain S. … Lipinski M. (Mol. Cell. Biol. 1998) 2 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for DNAJA2 Gene

Sources for DNAJA2 Gene

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