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Aliases for DNAJA2 Gene

Aliases for DNAJA2 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A2 2 3 5
  • Cell Cycle Progression Restoration Gene 3 Protein 3 4
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 2 2 3
  • Renal Carcinoma Antigen NY-REN-14 3 4
  • HIRIP4 3 4
  • DNJ3 3 4
  • CPR3 3 4
  • DJ3 3 4
  • DnaJ Homolog Subfamily A Member 2 3
  • Cell Cycle Progression 3 Protein 3
  • HIRA Interacting Protein 4 3
  • HIRA-Interacting Protein 4 4
  • PRO3015 3
  • DJA2 3
  • DNAJ 3
  • RDJ2 3

External Ids for DNAJA2 Gene

Previous GeneCards Identifiers for DNAJA2 Gene

  • GC16M037401
  • GC16M046730
  • GC16M046771
  • GC16M045547
  • GC16M032879

Summaries for DNAJA2 Gene

Entrez Gene Summary for DNAJA2 Gene

  • The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNAJA2 Gene

DNAJA2 (DnaJ Heat Shock Protein Family (Hsp40) Member A2) is a Protein Coding gene. Diseases associated with DNAJA2 include Subacute Bacterial Endocarditis and Adult Syndrome. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA1.

UniProtKB/Swiss-Prot for DNAJA2 Gene

  • Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Gene Wiki entry for DNAJA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA2 Gene

Genomics for DNAJA2 Gene

Regulatory Elements for DNAJA2 Gene

Enhancers for DNAJA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G047034 0.5 ENCODE 11.7 -59.6 -59617 0.2 POLR2A SMARCA4 GLIS1 DNAJA2 GPT2 GC16M047034 ENSG00000259983
GH16G047033 0.5 ENCODE 11.7 -60.2 -60182 0.9 POLR2A SMARCA4 GLIS1 KDM1A DNAJA2 GPT2 GC16M047034 ENSG00000259983
GH16G047037 1.6 FANTOM5 Ensembl ENCODE 2 -64.2 -64178 1.3 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A SLC30A9 CBX5 ZNF143 ZNF207 DNAJA2 GC16M047034 GC16P047062
GH16G046972 1.1 ENCODE 0.7 +0.3 313 3.3 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 KLF13 SP3 ENSG00000261131 ENSG00000261173 DNAJA2 GC16M046921
GH16G046970 0.7 ENCODE 0.7 +3.5 3495 0.2 MXI1 FOXA2 SAP130 ARID4B ZNF644 THRB RARA ZNF7 YY1 TEAD3 DNAJA2 GC16M046921
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJA2 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085505 388 2001 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 SP3 SP5 NFYC

Genomic Location for DNAJA2 Gene

Chromosome:
16
Start:
46,955,362 bp from pter
End:
46,973,788 bp from pter
Size:
18,427 bases
Orientation:
Minus strand

Genomic View for DNAJA2 Gene

Genes around DNAJA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA2 Gene

Proteins for DNAJA2 Gene

  • Protein details for DNAJA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60884-DNJA2_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 2
    Protein Accession:
    O60884
    Secondary Accessions:
    • B2R7L7
    • O14711

    Protein attributes for DNAJA2 Gene

    Size:
    412 amino acids
    Molecular mass:
    45746 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJA2 Gene

Post-translational modifications for DNAJA2 Gene

  • Ubiquitination at Lys25, Lys131, isoforms=134, isoforms=152, Lys199, and isoforms=326
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJA2 Gene

Domains & Families for DNAJA2 Gene

Gene Families for DNAJA2 Gene

Suggested Antigen Peptide Sequences for DNAJA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJA2: view

No data available for UniProtKB/Swiss-Prot for DNAJA2 Gene

Function for DNAJA2 Gene

Molecular function for DNAJA2 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Gene Ontology (GO) - Molecular Function for DNAJA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 24318877
GO:0005515 protein binding IPI 22085931
GO:0005524 ATP binding IEA --
GO:0031072 heat shock protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DNAJA2: view
genes like me logo Genes that share phenotypes with DNAJA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJA2 Gene

Localization for DNAJA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA2 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJA2 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS,IDA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DNAJA2: view

Pathways & Interactions for DNAJA2 Gene

genes like me logo Genes that share pathways with DNAJA2: view

Pathways by source for DNAJA2 Gene

1 KEGG pathway for DNAJA2 Gene

Gene Ontology (GO) - Biological Process for DNAJA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0008284 positive regulation of cell proliferation TAS 9383053
GO:0009408 response to heat IEA --
GO:0032781 positive regulation of ATPase activity IEA --
GO:0042026 protein refolding IDA 21231916
genes like me logo Genes that share ontologies with DNAJA2: view

No data available for SIGNOR curated interactions for DNAJA2 Gene

Drugs & Compounds for DNAJA2 Gene

(2) Drugs for DNAJA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for DNAJA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DNAJA2: view

Transcripts for DNAJA2 Gene

Unigene Clusters for DNAJA2 Gene

DnaJ (Hsp40) homolog, subfamily A, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3: - - - -
SP4:
SP5:
SP6:

Relevant External Links for DNAJA2 Gene

GeneLoc Exon Structure for
DNAJA2
ECgene alternative splicing isoforms for
DNAJA2

Expression for DNAJA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJA2 Gene

Protein differential expression in normal tissues from HIPED for DNAJA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJA2 Gene



Protein tissue co-expression partners for DNAJA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJA2 Gene:

DNAJA2

SOURCE GeneReport for Unigene cluster for DNAJA2 Gene:

Hs.368078

Evidence on tissue expression from TISSUES for DNAJA2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Skin(4.3)
  • Heart(2.5)
  • Muscle(2.1)
  • Spleen(2.1)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DNAJA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJA2 Gene

Orthologs for DNAJA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
DNAJA2 34
  • 95.15 (n)
-- 35
  • 94 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DNAJA2 34 35
  • 99.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJA2 34 35
  • 93.93 (n)
mouse
(Mus musculus)
Mammalia Dnaja2 34 16 35
  • 92.64 (n)
rat
(Rattus norvegicus)
Mammalia Dnaja2 34
  • 92.39 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJA2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA2 34 35
  • 85.64 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJA2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja2 34
  • 81.54 (n)
Str.6675 34
African clawed frog
(Xenopus laevis)
Amphibia dnaja2-prov 34
zebrafish
(Danio rerio)
Actinopterygii dnaja2l 35
  • 84 (a)
OneToMany
dnaja2 34 35
  • 74.45 (n)
Dr.26979 34
fruit fly
(Drosophila melanogaster)
Insecta DnaJ-H 36 35
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-19 34 35
  • 55.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 34 35 37
  • 56.75 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03333g 34
  • 56.26 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL257C 34
  • 53.57 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons J2 34
  • 56.2 (n)
soybean
(Glycine max)
eudicotyledons Gma.1634 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8056 34
rice
(Oryza sativa)
Liliopsida Os03g0787300 34
  • 55.43 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.315 34
wheat
(Triticum aestivum)
Liliopsida Ta.18956 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mas5 34
  • 53.48 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07414 34
  • 52.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
Species where no ortholog for DNAJA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJA2 Gene

ENSEMBL:
Gene Tree for DNAJA2 (if available)
TreeFam:
Gene Tree for DNAJA2 (if available)

Paralogs for DNAJA2 Gene

Paralogs for DNAJA2 Gene

(11) SIMAP similar genes for DNAJA2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DNAJA2 Gene

genes like me logo Genes that share paralogs with DNAJA2: view

Variants for DNAJA2 Gene

Sequence variations from dbSNP and Humsavar for DNAJA2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000603807 -- 46,974,774(+) TAATG(A/T)TTCTT upstream-variant-2KB
rs1000673929 -- 46,973,767(+) AGGCG(C/G)GGCCA upstream-variant-2KB
rs1000860093 -- 46,962,623(+) AGCAG(A/C)AAGAC intron-variant
rs1000869647 -- 46,955,728(+) CATCT(G/T)ATGTC utr-variant-3-prime
rs1000870635 -- 46,956,183(+) CACTC(-/AA)GACAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJA2 Gene

Variant ID Type Subtype PubMed ID
nsv1066115 CNV gain 25217958

Variation tolerance for DNAJA2 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJA2 Gene

Human Gene Mutation Database (HGMD)
DNAJA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA2 Gene

Disorders for DNAJA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAJA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
subacute bacterial endocarditis
  • endocarditis lenta
adult syndrome
  • acro-dermato-ungual-lacrimal-tooth syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJA2
genes like me logo Genes that share disorders with DNAJA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJA2 Gene

Publications for DNAJA2 Gene

  1. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch J.N. … Gestwicki J.E. (J. Biol. Chem. 2014) 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PMID: 15308774) Kho Y. … Zhao Y. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3 64

Products for DNAJA2 Gene

Sources for DNAJA2 Gene

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