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DNAJA2 Gene

protein-coding   GIFtS: 59
GCID: GC16M046931

DnaJ (Hsp40) Homolog, Subfamily A, Member 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily A, Member 21 2     DNJ32
CPR32 3 5     PRO30152
Cell Cycle Progression Restoration Gene 3 Protein2 3     RDJ22
Renal Carcinoma Antigen NY-REN-142 3     Cell Cycle Progression 3 Protein2
HIRIP42 3     DnaJ Homolog Subfamily A Member 22
HIRA-Interacting Protein 42 3     HIRA Interacting Protein 42
DJ32 5     Dj33
DJA22     Dnj33
DNAJ2     

External Ids:    HGNC: 148841   Entrez Gene: 102942   Ensembl: ENSG000000693457   OMIM: 6113225   UniProtKB: O608843   

Export aliases for DNAJA2 gene to outside databases

Previous GC identifers: GC16M037401 GC16M046730 GC16M046771 GC16M045547 GC16M032879


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJA2 Gene:
The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which
regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct
domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich
region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene
works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DNAJA2 Gene:
DNAJA2 (DnaJ (Hsp40) homolog, subfamily A, member 2) is a protein-coding gene. Diseases associated with DNAJA2 include subacute bacterial endocarditis, and adult syndrome. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA1.

UniProtKB/Swiss-Prot: DNJA2_HUMAN, O60884
Function: Co-chaperone of Hsc70

Gene Wiki entry for DNAJA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJA2 gene promoter:
         GATA-3   AP-1   MyoD   HSF1 (long)   GATA-2   Ik-2   POU2F1   POU2F1a   HOXA5   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJA2 promoter sequence
   Search Chromatin IP Primers for DNAJA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

DNAJA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJA2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M046931:  view genomic region     (about GC identifiers)

Start:
46,989,274 bp from pter      End:
47,007,699 bp from pter
Size:
18,426 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNJA2_HUMAN, O60884 (See protein sequence)
Recommended Name: DnaJ homolog subfamily A member 2 precursor  
Size: 412 amino acids; 45746 Da
Secondary accessions: B2R7L7 O14711

Explore the universe of human proteins at neXtProt for DNAJA2: NX_O60884

Explore proteomics data for DNAJA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys26, Lys131, Lys134, Lys152, Lys158, Lys199, Lys326
  • Modification sites at PhosphoSitePlus

  • See DNAJA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005871.1  
    ENSEMBL proteins: 
     ENSP00000314030   ENSP00000460104   ENSP00000454580  

    DNAJA2 Human Recombinant Protein Products:

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    OriGene MassSpec for DNAJA2
    OriGene Custom Protein Services for DNAJA2
    GenScript Custom Purified and Recombinant Proteins Services for DNAJA2
    Novus Biologicals DNAJA2 Protein
    Novus Biologicals DNAJA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJA2

    DNAJA2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals DNAJA2 Antibodies
    Abcam antibodies for DNAJA2
    Cloud-Clone Corp. Antibodies for DNAJA2
    ThermoFisher Antibodies for DNAJA2
    LSBio Antibodies in human, mouse, rat for DNAJA2

    DNAJA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNAJA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNAJA2
    Cloud-Clone Corp. CLIAs for DNAJA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    Selected InterPro protein domains (see all 6):
     IPR008971 HSP40/DnaJ_pept-bd
     IPR012724 DnaJ
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry O60884

    ProtoNet protein and cluster: O60884

    2 Blocks protein domains:
    IPB001305 DnaJ central domain (CXXCXGXG)
    IPB003095 DnaJ protein family signature


    UniProtKB/Swiss-Prot: DNJA2_HUMAN, O60884
    Similarity: Contains 1 CR-type zinc finger
    Similarity: Contains 1 J domain


    DNAJA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJA2_HUMAN, O60884
    Function: Co-chaperone of Hsc70

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0031072heat shock protein binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    DNAJA2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJA2:
    hsa-mir-26b-5p (MIRT028942), hsa-mir-19b-3p (MIRT031115), hsa-mir-16-5p (MIRT031498), hsa-mir-615-3p (MIRT039924)

    Block miRNA regulation of human, mouse, rat DNAJA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJA2 (see all 100):
    hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-15a hsa-miR-138-2* hsa-miR-4267 hsa-miR-1273d hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJA2
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAJA2

    Clone
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    OriGene clones in human, mouse for DNAJA2 (see all 7)
    OriGene ORF clones in mouse, rat for DNAJA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJA2 (NM_005880)
    Sino Biological Human cDNA Clone for DNAJA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DNAJA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJA2_HUMAN, O60884: Membrane; Lipid-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    DNAJA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for DNAJA2):
        Protein processing in endoplasmic reticulum


    DNAJA2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA2: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJA2 (O608841, 2, 3 ENSP000003140304) via UniProtKB, MINT, STRING, and/or I2D (see all 217)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0008284positive regulation of cell proliferation TAS9383053
    GO:0009408response to heat IEA--

    DNAJA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJA2 (DNJA2)

    3 Novoseek inferred chemical compound relationships for DNAJA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 29.3 8 10493815 (4)
    adp 28.4 5 10493815 (2), 8922377 (1)
    zinc 3.28 6 12941935 (4)



    DNAJA2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJA2 gene: 
    NM_005880.3  

    Unigene Cluster for DNAJA2:

    DnaJ (Hsp40) homolog, subfamily A, member 2
    Hs.368078  [show with all ESTs]
    Unigene Representative Sequence: NM_005880
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317089(uc002eeo.2) ENST00000563158 ENST00000569553 ENST00000566791

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJA2 (see all 100):
    hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-15a hsa-miR-138-2* hsa-miR-4267 hsa-miR-1273d hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJA2
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJA2
    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJA2 (see all 7)
    OriGene ORF clones in mouse, rat for DNAJA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJA2 (NM_005880)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAJA2
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA2
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJA2
      QuantiFast Probe-based Assays in human, mouse, rat DNAJA2

    Additional mRNA sequence: 

    AF011793.1 AF088046.1 AJ001309.1 AK313031.1 BC013044.2 BC015809.2 Y13350.1 

    11 DOTS entries:

    DT.407476  DT.100809136  DT.100809135  DT.100809126  DT.100809132  DT.100809133  DT.87016563  DT.100809131 
    DT.120676773  DT.40197708  DT.65286794 

    Selected AceView cDNA sequences (see all 300):

    BE408572 AF088046 BG250409 BU677823 BU944024 CR621166 BX955324 BM790448 
    BQ774167 BE385295 BU622709 AU133833 BU181711 CD244898 AA923230 BU552496 
    BQ316907 AU139290 BU192281 AI222195 BE000270 BX955421 AA677397 BM930354 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                          -                                                                                             
    SP2:                                                                                            -                 -         
    SP3:                          -                 -     -     -                                                               
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for DNAJA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAAAATG
    DNAJA2 Expression
    About this image

    DNAJA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368078
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA2: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJA2
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA2
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJA2
    QuantiFast Probe-based Assays in human, mouse, rat DNAJA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJA2 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnaja21 , 5 DnaJ (Hsp40) homolog, subfamily A, member 21, 5 92.64(n)1
    99.51(a)1
      8 (41.61 cM)5
    564451  NM_019794.41  NP_062768.11 
     855376405 
    chicken
    (Gallus gallus)
    Aves DNAJA21 DnaJ (Hsp40) homolog, subfamily A, member 2 85.64(n)
    94.16(a)
      415744  NM_001005841.1  NP_001005841.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJA26
    DnaJ (Hsp40) homolog, subfamily A, member 2
    95(a)
    1 ↔ 1
    LGc(3421711-3439391)
    African clawed frog
    (Xenopus laevis)
    Amphibia dnaja2-prov2 DnaJ (Hsp40) homolog, subfamily A, member 2 78.95(n)    BC053791.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.269792 Danio rerio mRNA similar to DnaJ (Hsp40) homolog, subfamily more 76.54(n)    BC048042.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta DnaJ-H3 chaperone 38(a)   34A7   --
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-191 dnj-19 55.72(n)
    51.99(a)
      3565862  NM_072051.4  NP_504452.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDJ1(YNL064C)4
    YDJ11
    Type I HSP40 co-chaperone involved in regulation of more4
    YDJ11
    56.75(n)1
    50.51(a)1
      14(507097-505868)4
    8556611, 4  NP_014335.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons J21 J2 56.2(n)
    52.66(a)
      832267  NM_122127.2  NP_568412.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07873001 Os03g0787300 55.43(n)
    55.07(a)
      4334359  NM_001058032.1  NP_001051497.1 


    ENSEMBL Gene Tree for DNAJA2 (if available)
    TreeFam Gene Tree for DNAJA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJA2 gene
    DNAJA12  DNAJB112  DNAJA42  
    11 SIMAP similar genes for DNAJA2 using alignment to 3 protein entries:     DNJA2_HUMAN (see all proteins):
    DNAJC5B    DNAJB6    DNAJC25    DNAJA4    DNAJA1    HDJ2
    DNAJA3    DNAJB11    DNAJB4    DNAJB1    DNAJB5

    DNAJA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DNAJA2
    PGOHUM00000242208


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJA2 (see all 379)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926456191,2
    --46988934(+) GGAGAA/GAATGG 1 -- ds50010--------
    rs1828167681,2
    --46989055(+) AAGTGA/GTAAAT 1 -- ds50010--------
    rs1475722451,2
    --46989110(+) ATTATC/GTGTGC 1 -- ds50010--------
    rs1419412501,2
    C--46989142(+) TCTCTC/TGACAG 1 -- ds50010--------
    rs1874586661,2
    --46989573(+) TTTAAC/TACATT 1 -- ut310--------
    rs1411985091,2
    C--46989658(+) TCAAA-/TAAG  
            
    TGTGT
    1 -- ut310--------
    rs1915533701,2
    --46989730(+) CATCCA/GTTTCA 1 -- ut310--------
    rs341410591,2
    C,F--46989764(+) AACCAG/CCCTTT 1 -- ut314Minor allele frequency- C:0.05NA 126
    rs1483682871,2
    C--46989905(+) AATGGC/TTTCTC 1 -- ut310--------
    rs1415272771,2
    --46989913(+) CTCCAA/GTTCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DNAJA2 (46989274 - 47007699 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJA2: --
    Human Gene Mutation Database (HGMD): DNAJA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJA2
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611322    OMIM disorders: --

    14 diseases for DNAJA2:    About MalaCards
    subacute bacterial endocarditis    adult syndrome    endocarditis    nephrogenic diabetes insipidus
    diabetes insipidus    wegener's granulomatosis    brain cancer    cystic fibrosis
    renal cell carcinoma    tuberculosis    rheumatoid arthritis    arthritis
    hypoxia    melanoma

    1 disease from the University of Copenhagen DISEASES database for DNAJA2:
    ADULT syndrome

    DNAJA2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DNAJA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 39.7 5 1370300 (2), 8334160 (2), 9159391 (1)
    tumors 0 1 11707338 (1)


    Export disorders for DNAJA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJA2 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with DNAJA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)1, 2 Kho Y.... Zhao Y. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. (PubMed id 10816573)1, 2 Terada K. and Mori M. (J. Biol. Chem. 2000)
    5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    7. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PubMed id 9710638)1, 3 Lorain S.... Lipinski M. (Mol. Cell. Biol. 1998)
    8. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PubMed id 9383053)1, 2 Edwards M.C.... Elledge S.J. (Genetics 1997)
    9. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PubMed id 24318877)1 Rauch J.N. and Gestwicki J.E. (J. Biol. Chem. 2014)
    10. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10294 HGNC: 14884 AceView: DNAJA2 Ensembl:ENSG00000069345 euGenes: HUgn10294
    ECgene: DNAJA2 Kegg: 10294 H-InvDB: DNAJA2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNAJA2 gene:
    Search GeneIP for patents involving DNAJA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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