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Aliases for DNAJA1 Gene

Aliases for DNAJA1 Gene

  • DnaJ (Hsp40) Homolog, Subfamily A, Member 1 2 3
  • Heat Shock 40 KDa Protein 4 3 4
  • DnaJ Protein Homolog 2 3 4
  • Heat Shock Protein J2 3 4
  • Human DnaJ Protein 2 3 4
  • HSJ-2 3 4
  • HDJ-2 3 4
  • HSPF4 3 4
  • HSJ2 3 4
  • HDJ2 3 4
  • HSDJ 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 7 3
  • Developmentally Down-Regulated 7 2
  • Neural Precursor Cell Expressed 2
  • Heat Shock Protein, DNAJ-Like 2 3
  • NEDD7 3
  • DNAJ2 4
  • DJ-2 3
  • DjA1 3

External Ids for DNAJA1 Gene

Previous HGNC Symbols for DNAJA1 Gene

  • HSJ2

Previous GeneCards Identifiers for DNAJA1 Gene

  • GC09P033337
  • GC09P033194
  • GC09P033015

Summaries for DNAJA1 Gene

Entrez Gene Summary for DNAJA1 Gene

  • This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

GeneCards Summary for DNAJA1 Gene

DNAJA1 (DnaJ (Hsp40) Homolog, Subfamily A, Member 1) is a Protein Coding gene. Among its related pathways are Regulation of Androgen receptor activity and Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include ubiquitin protein ligase binding and chaperone binding. An important paralog of this gene is DNAJA4.

UniProtKB/Swiss-Prot for DNAJA1 Gene

  • Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Gene Wiki entry for DNAJA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA1 Gene

Genomics for DNAJA1 Gene

Regulatory Elements for DNAJA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJA1 Gene

Chromosome:
9
Start:
33,025,211 bp from pter
End:
33,039,907 bp from pter
Size:
14,697 bases
Orientation:
Plus strand

Genomic View for DNAJA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DNAJA1 Gene

Proteins for DNAJA1 Gene

  • Protein details for DNAJA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31689-DNJA1_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 1
    Protein Accession:
    P31689
    Secondary Accessions:
    • Q5T7Q0
    • Q86TL9

    Protein attributes for DNAJA1 Gene

    Size:
    397 amino acids
    Molecular mass:
    44868 Da
    Quaternary structure:
    • Identified in a complex with HSPA1B and BAX.

    Three dimensional structures from OCA and Proteopedia for DNAJA1 Gene

    Alternative splice isoforms for DNAJA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA1 Gene

Proteomics data for DNAJA1 Gene at MOPED

Post-translational modifications for DNAJA1 Gene

  • Ubiquitination at Lys 14, Lys 37, Lys 46, Lys 105, Lys 136, Lys 143, Lys 144, Lys 246, Lys 296, Lys 301, Lys 344, and Lys 350
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJA1 Gene

Domains & Families for DNAJA1 Gene

Gene Families for DNAJA1 Gene

Graphical View of Domain Structure for InterPro Entry

P31689

UniProtKB/Swiss-Prot:

DNJA1_HUMAN :
  • Contains 1 J domain.
  • Contains 1 CR-type zinc finger.
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 1 CR-type zinc finger.
genes like me logo Genes that share domains with DNAJA1: view

Function for DNAJA1 Gene

Molecular function for DNAJA1 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).
UniProtKB/Swiss-Prot Induction:
Up-regulated by heat shock.

Gene Ontology (GO) - Molecular Function for DNAJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12150907
GO:0005515 protein binding IPI 22085931
GO:0005524 ATP binding IEA --
GO:0030544 Hsp70 protein binding IDA 14752510
GO:0031072 heat shock protein binding --
genes like me logo Genes that share ontologies with DNAJA1: view
genes like me logo Genes that share phenotypes with DNAJA1: view

Animal Models for DNAJA1 Gene

MGI Knock Outs for DNAJA1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DNAJA1 Gene

Localization for DNAJA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA1 Gene

Membrane; Lipid-anchor. Cytoplasm. Microsome. Nucleus. Cytoplasm, perinuclear region. Mitochondrion. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJA1 Gene COMPARTMENTS Subcellular localization image for DNAJA1 gene
Compartment Confidence
cytosol 5
extracellular 5
endoplasmic reticulum 4
mitochondrion 3
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for DNAJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA 21231916
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DNAJA1: view

Pathways & Interactions for DNAJA1 Gene

genes like me logo Genes that share pathways with DNAJA1: view

Pathways by source for DNAJA1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DNAJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8334160
GO:0006986 response to unfolded protein TAS 8334160
GO:0007283 spermatogenesis IEA --
GO:0009408 response to heat IEA --
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with DNAJA1: view

No data available for SIGNOR curated interactions for DNAJA1 Gene

Drugs & Compounds for DNAJA1 Gene

No Compound Related Data Available

Transcripts for DNAJA1 Gene

Unigene Clusters for DNAJA1 Gene

DnaJ (Hsp40) homolog, subfamily A, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - -
SP4: - - -
SP5: - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - - - - - -

Relevant External Links for DNAJA1 Gene

GeneLoc Exon Structure for
DNAJA1
ECgene alternative splicing isoforms for
DNAJA1

Expression for DNAJA1 Gene

mRNA expression in normal human tissues for DNAJA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJA1 Gene



SOURCE GeneReport for Unigene cluster for DNAJA1 Gene Hs.445203

mRNA Expression by UniProt/SwissProt for DNAJA1 Gene

P31689-DNJA1_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.
genes like me logo Genes that share expression patterns with DNAJA1: view

Protein tissue co-expression partners for DNAJA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for DNAJA1 Gene

Orthologs for DNAJA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJA1 35
  • 94.21 (n)
  • 98.74 (a)
DNAJA1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA1 35
  • 94.46 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dnaja1 35
  • 92.02 (n)
  • 99.5 (a)
Dnaja1 16
Dnaja1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJA1 35
  • 99.58 (n)
  • 100 (a)
DNAJA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnaja1 35
  • 91.86 (n)
  • 99.5 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJA1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA1 35
  • 78.17 (n)
  • 91.18 (a)
DNAJA1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja1 35
  • 76.91 (n)
  • 86.4 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
dnaja1 35
  • 68.11 (n)
  • 71.76 (a)
dnaja1 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8863 37
  • 59 (a)
DnaJ-H 37
  • 36 (a)
Droj2 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-12 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 36
  • 47 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12175 35
wheat
(Triticum aestivum)
Liliopsida Ta.357 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10384 36
  • 63 (a)
OneToMany
Species with no ortholog for DNAJA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJA1 Gene

ENSEMBL:
Gene Tree for DNAJA1 (if available)
TreeFam:
Gene Tree for DNAJA1 (if available)

Paralogs for DNAJA1 Gene

Paralogs for DNAJA1 Gene

(10) SIMAP similar genes for DNAJA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJA1: view

Variants for DNAJA1 Gene

Sequence variations from dbSNP and Humsavar for DNAJA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7296 -- 33,039,026(+) GTGTT(A/T)TAAAA utr-variant-3-prime
rs1042345 -- 33,039,154(+) CATTT(C/T)TAGGC downstream-variant-500B
rs1042376 -- 33,039,548(+) ATATA(C/T)ATATA downstream-variant-500B
rs1042425 -- 33,036,977(+) ATGTG(A/C)CCATA intron-variant
rs1330692 -- 33,034,667(-) ATGAG(A/G)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJA1 Gene

Variant ID Type Subtype PubMed ID
nsv893017 CNV Gain 21882294
nsv8438 CNV Gain 18304495

Variation tolerance for DNAJA1 Gene

Residual Variation Intolerance Score: 15.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJA1 Gene

HapMap Linkage Disequilibrium report
DNAJA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA1 Gene

Disorders for DNAJA1 Gene

Relevant External Links for DNAJA1

Genetic Association Database (GAD)
DNAJA1
Human Genome Epidemiology (HuGE) Navigator
DNAJA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJA1
genes like me logo Genes that share disorders with DNAJA1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJA1 Gene

Publications for DNAJA1 Gene

  1. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. (PMID: 8334160) Chellaiah A. … Mohanakumar T. (Biochim. Biophys. Acta 1993) 2 23 67
  2. Functional divergence between co-chaperones of Hsc70. (PMID: 18684711) Tzankov S. … Young J.C. (J. Biol. Chem. 2008) 23 67
  3. Co-chaperone FKBP38 promotes HERG trafficking. (PMID: 17569659) Walker V.E. … Shrier A. (J. Biol. Chem. 2007) 23 67
  4. HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway. (PMID: 16818651) Wang C.C. … McBride W.H. (Cancer Res. 2006) 23 67
  5. Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway. (PMID: 16854979) Cintron N.S. … Toft D. (J. Biol. Chem. 2006) 23 67

Products for DNAJA1 Gene

Sources for DNAJA1 Gene

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