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DNAJA1 Gene

protein-coding   GIFtS: 62
GCID: GC09P033025

DnaJ (Hsp40) Homolog, Subfamily A, Member 1


(Previous symbol: HSJ2)
  See DNAJA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily A, Member 11 2     Neural Precursor Cell Expressed1
HSJ21 2 3     DJ-22
DnaJ Protein Homolog 22 3     DjA12
Heat Shock 40 KDa Protein 42 3     NEDD72
Heat Shock Protein J22 3     DnaJ Homolog Subfamily A Member 12
Human DnaJ Protein 22 3     hDJ-22
HDJ22 3     Heat Shock Protein, DNAJ-Like 22
HSDJ2 3     Neural Precursor Cell Expressed, Developmentally Down-Regulated 72
HSJ-22 3     DNAJ23
HSPF42 3     hDj-23
Developmentally Down-Regulated 71     

External Ids:    HGNC: 52291   Entrez Gene: 33012   Ensembl: ENSG000000860617   OMIM: 6028375   UniProtKB: P316893   

Export aliases for DNAJA1 gene to outside databases

Previous GC identifers: GC09P033337 GC09P033194 GC09P033015


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJA1 Gene:
DNAJA1 (DnaJ (Hsp40) homolog, subfamily A, member 1) is a protein-coding gene. Diseases associated with DNAJA1 include oculopharyngeal muscular dystrophy. GO annotations related to this gene include unfolded protein binding and low-density lipoprotein particle receptor binding. An important paralog of this gene is DNAJA2.

UniProtKB/Swiss-Prot: DNJA1_HUMAN, P31689
Function: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria

Gene Wiki entry for DNAJA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJA1 gene promoter:
         COUP   FOXD3   Evi-1   HEN1   MZF-1   COUP-TF   HSF2   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJA1 promoter sequence
   Search Chromatin IP Primers for DNAJA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p21.1   HGNC cytogenetic band: 9p13.3

DNAJA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033025:  view genomic region     (about GC identifiers)

Start:
33,025,209 bp from pter      End:
33,039,905 bp from pter
Size:
14,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNJA1_HUMAN, P31689 (See protein sequence)
Recommended Name: DnaJ homolog subfamily A member 1 precursor  
Size: 397 amino acids; 44868 Da
2 PDB 3D structures from and Proteopedia for DNAJA1:
2LO1 (3D)        2M6Y (3D)    
Secondary accessions: Q5T7Q0 Q86TL9
Alternative splicing: 2 isoforms:  P31689-1   P31689-2   (High expression in testis and lung but low in thymus, prostate, colon and liver)

Explore the universe of human proteins at neXtProt for DNAJA1: NX_P31689

Explore proteomics data for DNAJA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14, Lys32, Lys37, Lys46, Lys66, Lys105, Lys125, Lys136, Lys143, Lys144,
                                 Lys246, Lys296, Lys301, Lys338, Lys344, Lys350
  • Modification sites at PhosphoSitePlus

  • See DNAJA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001530.1  
    ENSEMBL proteins: 
     ENSP00000369127   ENSP00000439010  

    DNAJA1 Human Recombinant Protein Products:

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    Novus Biologicals DNAJA1 Proteins
    Novus Biologicals DNAJA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DNAJA1 

     
    antibodies-online proteins for DNAJA1 (8 products) 

     
    antibodies-online peptides for DNAJA1

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    antibodies-online antibodies for DNAJA1 (31 products) 

    DNAJA1 Assay Products:

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    antibodies-online kits for DNAJA1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    Selected InterPro protein domains (see all 6):
     IPR008971 HSP40/DnaJ_pept-bd
     IPR012724 DnaJ
     IPR002939 DnaJ_C
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry P31689

    ProtoNet protein and cluster: P31689

    2 Blocks protein domains:
    IPB001305 DnaJ central domain (CXXCXGXG)
    IPB003095 DnaJ protein family signature


    UniProtKB/Swiss-Prot: DNJA1_HUMAN, P31689
    Similarity: Contains 1 CR-type zinc finger
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJA1_HUMAN, P31689
    Function: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0031072heat shock protein binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0050750low-density lipoprotein particle receptor binding IDA15082773
         
    Find genes that share ontologies with DNAJA1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dnaja1):
     endocrine/exocrine gland  growth/size/body  reproductive system 

    Find genes that share phenotypes with DNAJA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DNAJA1: Dnaja1tm1(KOMP)Vlcg Dnaja1tm1Kate

       genOway: Develop your customized and physiologically relevant rodent model for DNAJA1

    miRNA
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    miRTarBase miRNAs that target DNAJA1:
    hsa-mir-193b-3p (MIRT041294), hsa-mir-16-5p (MIRT032047), hsa-mir-30a-5p (MIRT028629)

    Block miRNA regulation of human, mouse, rat DNAJA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJA1 (see all 9):
    hsa-miR-217 hsa-miR-205 hsa-miR-193a-3p hsa-miR-625* hsa-miR-509-5p hsa-miR-921 hsa-miR-509-3-5p hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJA1

    Gene Editing
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    OriGene ORF clones in mouse, rat for DNAJA1
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    GenScript: all cDNA clones in your preferred vector: DNAJA1 (NM_001539)
    Sino Biological Human cDNA Clone for DNAJA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA1
    Addgene plasmids for DNAJA1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJA1_HUMAN, P31689: Membrane; Lipid-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DNAJA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    3Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with DNAJA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DNAJA1
        Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)

    2 BioSystems Pathways for DNAJA1
        Diurnally regulated genes with circadian orthologs
    Regulation of Androgen receptor activity



    1 Kegg Pathway  (Kegg details for DNAJA1):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA1: 
              TGFB Signaling Targets in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJA1 (P316891, 2, 3 ENSP000003691274) via UniProtKB, MINT, STRING, and/or I2D (see all 1374)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224979Q9Y3332, 3, ENSP000004140064MINT-62694 MINT-62596 MINT-62770 I2D: score=5 STRING: ENSP00000414006
    ENSG00000236826Q9Y3332, 3, ENSP000004146344MINT-62694 MINT-62596 MINT-62770 I2D: score=5 STRING: ENSP00000414634
    LSM2Q9Y3332, 3, ENSP000003648134MINT-62694 MINT-62596 MINT-62770 I2D: score=5 STRING: ENSP00000364813
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006986response to unfolded protein TAS8334160
    GO:0007283spermatogenesis IEA--
    GO:0009408response to heat IEA--
    GO:0030317sperm motility IEA--

    Find genes that share ontologies with DNAJA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJA1 (DNJA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJA1 gene: 
    NM_001539.2  

    Unigene Cluster for DNAJA1:

    DnaJ (Hsp40) homolog, subfamily A, member 1
    Hs.445203  [show with all ESTs]
    Unigene Representative Sequence: AK095541
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330899(uc003zse.1 uc003zsd.1 uc011lnt.1) ENST00000495015
    ENST00000465677 ENST00000544625
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DNAJA1 (see all 9):
    hsa-miR-217 hsa-miR-205 hsa-miR-193a-3p hsa-miR-625* hsa-miR-509-5p hsa-miR-921 hsa-miR-509-3-5p hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidDNAJA1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJA1
    Addgene plasmids for DNAJA1 
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    OriGene qPCR primer pairs and template standards for DNAJA1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA1
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJA1
      QuantiFast Probe-based Assays in human, mouse, rat DNAJA1

    Additional mRNA sequence: 

    AJ277242.1 AK095541.1 AK289623.1 AK298725.1 AY186741.1 BC008182.1 BT007292.1 D13388.1 
    L08069.1 

    Selected DOTS entries (see all 37):

    DT.92453279  DT.100877169  DT.100877171  DT.121171489  DT.92453266  DT.75177015  DT.87016775  DT.95211410 
    DT.40133162  DT.121171501  DT.97855515  DT.100890782  DT.119392  DT.121171458  DT.100038979  DT.119391 
    DT.121171542  DT.100877173  DT.121171523  DT.75107910  DT.100877167  DT.121171480  DT.100685089  DT.121171465 

    Selected AceView cDNA sequences (see all 765):

    CA396678 AI718164 AI569525 W92189 BM741833 BQ639917 AI097343 BU538096 
    BQ775151 BU171365 AU123744 AA470409 CD244445 R42586 AU077122 CR611988 
    AI888098 BP338864 BQ221010 AI420160 BU673965 BM800667 AI188614 BP338159 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
    SP1:                          -                                         -                                               -                       -               
    SP2:                                                                    -                                               -                                       
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -               
    SP4:                          -                             -           -                                                                                       
    SP5:                          -                                         -                                                                                       


    ECgene alternative splicing isoforms for DNAJA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATTTATC
    DNAJA1 Expression
    About this image


    DNAJA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Tooth (Integumentary System)
             Dental Enamel
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    DNAJA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445203
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJA1: 
              TGFB Signaling Targets in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DNAJA1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJA1
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJA1
    QuantiFast Probe-based Assays in human, mouse, rat DNAJA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJA1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnaja11 , 5 DnaJ (Hsp40) homolog, subfamily A, member 11, 5 92.02(n)1
    99.5(a)1
      4 (20.46 cM)5
    155021  NM_001164671.11  NP_001158143.11 
     407221505 
    chicken
    (Gallus gallus)
    Aves DNAJA11 DnaJ (Hsp40) homolog, subfamily A, member 1 78.17(n)
    91.18(a)
      427376  NM_001012945.1  NP_001012963.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJA16
    DnaJ (Hsp40) homolog, subfamily A, member 1
    93(a)
    1 ↔ 1
    GL343257.1(97489-106836)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042291.12   -- 76.12(n)    BC042291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044445.12   -- 74.13(n)   323922  BC044445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88633 chaperone 59(a)
    (best of 2)
      87E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-126
    Protein DNJ-12 (dnj-12) mRNA, complete cds
    52(a)
    1 → many
    I(14756858-14759354) WBGene00001030
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDJ16
    Type I HSP40 co-chaperone involved in regulation o...
    47(a)
    1 → many
    XIV(505868-507097) YNL064C
    rice
    (Oryza sativa)
    Liliopsida Os.121752 Oryza sativa (japonica cultivar-group) cDNA cloneJ013067J21, full insert sequence less 69.25(n)    AK066420.1 


    ENSEMBL Gene Tree for DNAJA1 (if available)
    TreeFam Gene Tree for DNAJA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJA1 gene
    DNAJA22  DNAJB112  DNAJA42  
    10 SIMAP similar genes for DNAJA1 using alignment to 2 protein entries:     DNJA1_HUMAN (see all proteins):
    HDJ2    DNAJA4    MST104    DKFZp434N1728    DNAJA2    DNAJB8
    DNAJB4    DNAJB1    DNAJB5    DNAJB11

    Find genes that share paralogs with DNAJA1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for DNAJA1 (see all 6)
    PGOHUM00000248412 PGOHUM00000244822 PGOHUM00000246215 PGOHUM00000240391 PGOHUM00000243335


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DNAJA1 (see all 456)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122363721,2
    C,F,H--33023215(+) acttaT/Cgtgat 1 -- us2k16Minor allele frequency- C:0.06NS EA NA 654
    rs1420424511,2
    --33023320(+) AGGTTC/TAAGCG 1 -- us2k10--------
    rs1468467571,2
    --33023424(+) ACCAAA/GTTGGC 1 -- us2k10--------
    rs1426712481,2
    C--33023465(+) ATCCG-/CCCACC 1 -- us2k10--------
    rs108139231,2
    C,F,A,H--33023517(+) CGCCCG/AGCCTG 1 -- us2k120Minor allele frequency- A:0.18NS EA NA WA 2344
    rs1909262861,2
    --33023542(+) TGTATC/TACAAA 1 -- us2k10--------
    rs1483487831,2
    --33023566(+) GCCTGC/GTAATA 1 -- us2k10--------
    rs1416021251,2
    --33023573(+) AATATC/TAGACG 1 -- us2k10--------
    rs770148121,2
    C--33023648(+) TAAGAT/CTGAAA 1 -- us2k13Minor allele frequency- C:0.09NA EA 242
    rs1504838631,2
    C--33023702(+) AAAAGC/GCGTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJA1 (33025209 - 33039905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNAJA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8438CNV Gain18304495
    nsv893017CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJA1
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602837    OMIM disorders: --

    1 disease for DNAJA1:    
    About MalaCards
    oculopharyngeal muscular dystrophy


    Find genes that share disorders with DNAJA1           About GenesLikeMe

    1 Novoseek inferred disease relationship for DNAJA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 54.4 13 9839446 (3), 12417652 (1), 9382858 (1), 10717003 (1) (see all 7)

    Genetic Association Database (GAD): DNAJA1
    Human Genome Epidemiology (HuGE) Navigator: DNAJA1 (2 documents)

    Export disorders for DNAJA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJA1 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with DNAJA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. (PubMed id 8334160)1, 2, 3, 9 Chellaiah A.... Mohanakumar T. (Biochim. Biophys. Acta 1993)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    4. Expression of a novel DnaJA1 alternative splicing in human testis and sperm. (PubMed id 15595953)1, 2 Hu Y.... Sha J. (Int. J. Androl. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. (PubMed id 10816573)1, 2 Terada K. and Mori M. (J. Biol. Chem. 2000)
    7. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    8. HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria. (PubMed id 9192730)1, 2 Kanazawa M.... Mori M. (J. Biochem. 1997)
    9. Human cDNA encoding DnaJ protein homologue. (PubMed id 8334161)1, 2 Oh S.... Kato S. (Biochim. Biophys. Acta 1993)
    10. Characterization of HDJ-2, a human 40 kD heat shock protein. (PubMed id 9839446)1, 9 Davis A.R....Mohanakumar T. (amp 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3301 HGNC: 5229 AceView: DNAJA1 Ensembl:ENSG00000086061 euGenes: HUgn3301
    ECgene: DNAJA1 Kegg: 3301 H-InvDB: DNAJA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNAJA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNAJA1 gene:
    Search GeneIP for patents involving DNAJA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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