Aliases for DNAJA1 Gene
External Ids for DNAJA1 Gene
Previous HGNC Symbols for DNAJA1 Gene
Previous GeneCards Identifiers for DNAJA1 Gene
This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]
GeneCards Summary for DNAJA1 Gene
DNAJA1 (DnaJ Heat Shock Protein Family (Hsp40) Member A1) is a Protein Coding gene. Among its related pathways are Diurnally regulated genes with circadian orthologs and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include ubiquitin protein ligase binding and chaperone binding. An important paralog of this gene is DNAJA4.
UniProtKB/Swiss-Prot for DNAJA1 Gene
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).