Aliases for DNAJA1 Gene
External Ids for DNAJA1 Gene
Previous HGNC Symbols for DNAJA1 Gene
Previous GeneCards Identifiers for DNAJA1 Gene
GeneCards Summary for DNAJA1 Gene
DNAJA1 (DnaJ (Hsp40) Homolog, Subfamily A, Member 1) is a Protein Coding gene. Diseases associated with DNAJA1 include oculopharyngeal muscular dystrophy. Among its related pathways are Regulation of Androgen receptor activity and Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include unfolded protein binding and low-density lipoprotein particle receptor binding. An important paralog of this gene is DNAJA4.
UniProtKB/Swiss-Prot for DNAJA1 Gene
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).