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DNAI1 Gene

protein-coding   GIFtS: 60
GCID: GC09P034448

Dynein, Axonemal, Intermediate Chain 1

(Previous names: dynein, axonemal, intermediate polypeptide 1)
  See DNAI1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Intermediate Chain 11 2     ICS12
Dynein, Axonemal, Intermediate Polypeptide 11 2     Dynein Intermediate Chain 1, Axonemal2
CILD12 5     Immotile Cilia Syndrome 12
PCD2 5     Axonemal Dynein Intermediate Chain 13
DIC12     ICS5

External Ids:    HGNC: 29541   Entrez Gene: 270192   Ensembl: ENSG000001227357   OMIM: 6043665   UniProtKB: Q9UI463   

Export aliases for DNAI1 gene to outside databases

Previous GC identifers: GC09P034771 GC09P034628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAI1 Gene:
This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein
complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in
axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate
and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in
regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function
associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for DNAI1 Gene:
DNAI1 (dynein, axonemal, intermediate chain 1) is a protein-coding gene. Diseases associated with DNAI1 include kartagener syndrome, and ciliary dyskinesia, primary, 1, with or without situs inversus. GO annotations related to this gene include motor activity. An important paralog of this gene is DYNC1I1.

UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46
Function: Part of the dynein complex of respiratory cilia

Gene Wiki entry for DNAI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAI1 gene promoter:
         Brachyury   E47   C/EBPalpha   MZF-1   CHOP-10   POU2F1   FOXC1   POU2F1b   c-Myb   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAI1 promoter sequence
   Search Chromatin IP Primers for DNAI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

DNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAI1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034448:  view genomic region     (about GC identifiers)

Start:
34,457,412 bp from pter      End:
34,520,982 bp from pter
Size:
63,571 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46 (See protein sequence)
Recommended Name: Dynein intermediate chain 1, axonemal  
Size: 699 amino acids; 79283 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2
Secondary accessions: Q5T8G7 Q8NHQ7 Q9UEZ8

Explore the universe of human proteins at neXtProt for DNAI1: NX_Q9UI46

Explore proteomics data for DNAI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268357.1  NP_036276.1  

    ENSEMBL proteins: 
     ENSP00000395396   ENSP00000242317   ENSP00000434296   ENSP00000408129   ENSP00000443667  

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    Cloud-Clone Corp. Proteins for DNAI1

     
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    antibodies-online proteins for DNAI1 (3 products) 

     
    antibodies-online peptides for DNAI1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DN: Axonemal dyneins
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UI46

    ProtoNet protein and cluster: Q9UI46

    UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46
    Similarity: Belongs to the dynein intermediate chain family
    Similarity: Contains 5 WD repeats


    Find genes that share domains with DNAI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNAI1_HUMAN, Q9UI46
    Function: Part of the dynein complex of respiratory cilia

         Genatlas biochemistry entry for DNAI1:
    dynein axonemal motor protein intermediate chain,homolog of the Chlamydomonas reinhardtii gene IC78 which
    mutations are associated with the absence of outer dynein arms

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with DNAI1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DNAI1:
     Decreased nuclei size in G2M 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dnaic1):
     cardiovascular system  growth/size/body  immune system  nervous system  respiratory system 

    Find genes that share phenotypes with DNAI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dnaic1tm1.2Leo for DNAI1

       genOway: Develop your customized and physiologically relevant rodent model for DNAI1

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    hsa-miR-19b hsa-miR-518a-5p hsa-miR-2113 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidDNAI1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNAI1_HUMAN, Q9UI46: Cytoplasm, cytoskeleton, cilium axoneme
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton TAS10577904
    GO:0005874microtubule IEA--
    GO:0005929cilium IEA--
    GO:0030286dynein complex IEA--

    Find genes that share ontologies with DNAI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32


    Find genes that share SuperPaths with DNAI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNAI1):
        Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAI1
    Interactions:

        GeneGlobe Interaction Network for DNAI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAI1 (Q9UI463 ENSP000002423174) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAFAH1B1P430343, ENSP000003803784I2D: score=1 STRING: ENSP00000380378
    DCTN2ENSP000004089104STRING: ENSP00000408910
    DNAH1ENSP000004015144STRING: ENSP00000401514
    DNAH10ENSP000003867704STRING: ENSP00000386770
    DNAH12ENSP000002959374STRING: ENSP00000295937
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003351epithelial cilium movement IEA--
    GO:0008152metabolic process TAS10577904
    GO:0030030cell projection organization IEA--

    Find genes that share ontologies with DNAI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAI1

    1 Novoseek inferred chemical compound relationship for DNAI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    salicylic acid 38.8 5 17588170 (4), 12848825 (1)



    Find genes that share compounds with DNAI1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAI1 gene (2 alternative transcripts): 
    NM_001281428.1  NM_012144.3  

    Unigene Cluster for DNAI1:

    Dynein, axonemal, intermediate chain 1
    Hs.112667  [show with all ESTs]
    Unigene Representative Sequence: NM_012144
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470982 ENST00000437363 ENST00000242317(uc003zum.3) ENST00000488369
    ENST00000488790 ENST00000470169 ENST00000442556 ENST00000485580 ENST00000545019(uc011lom.1)

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    hsa-miR-19b hsa-miR-518a-5p hsa-miR-2113 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidDNAI1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DNAI1

    Additional mRNA sequence: 

    AF091619.1 AK290696.1 AK302186.1 AK302499.1 AK303937.1 AK314639.1 BC030583.2 

    7 DOTS entries:

    DT.200184  DT.300778  DT.92417933  DT.121166130  DT.97767548  DT.97775490  DT.95084076 

    Selected AceView cDNA sequences (see all 55):

    AF091619 BE348313 NM_012144 AI018373 AA609218 BE504837 AI306488 BM713632 
    AL117535 BX114274 BM127557 AW025946 AI953703 CB306705 AI377968 BU570266 
    AA923458 AA815264 AK057687 BM554168 BM013886 AI633178 BX100552 BE550140 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAI1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^
    SP1:                    -                             -     -     -                 -                                                                           
    SP2:                                                                                -                                                                           
    SP3:              -     -                             -     -     -                 -                                                                           
    SP4:                    -                             -     -     -                                                                                             
    SP5:              -     -                             -     -     -                                                                                             

    ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                      -               
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for DNAI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNAI1 Expression
    About this image


    DNAI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
    DNAI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112667
        Custom PCR Arrays for DNAI1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAI1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnaic11 , 5 dynein, axonemal, intermediate chain 11, 5 87.51(n)1
    88.57(a)1
      4 (21.75 cM)5
    689221  NM_175138.41  NP_780347.21 
     415697755 
    chicken
    (Gallus gallus)
    Aves DNAI11 dynein, axonemal, intermediate chain 1 72.19(n)
    70.86(a)
      431654  XM_003642965.2  XP_003643013.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAI16
    dynein, axonemal, intermediate chain 1
    72(a)
    1 ↔ 1
    GL343482.1(181732-390200)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165992 Xenopus laevis transcribed sequence with moderate similarity more 74.53(n)    CF288469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155082 Transcribed sequence with weak similarity to protein more 79.2(n)    BM317298.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93131 , 3 microtubule-based movement dynein
    ATPase3
    CG93131
    48(a)
    (best of 2)3
    55.36(n)1
    45.61(a)1
      57B53
    373741  NM_137686.51  NP_611530.51 


    ENSEMBL Gene Tree for DNAI1 (if available)
    TreeFam Gene Tree for DNAI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAI1 gene
    DYNC1I12  WDR342  DYNC1I22  WDR782  
    2 SIMAP similar genes for DNAI1 using alignment to 5 protein entries:     DNAI1_HUMAN (see all proteins):
    WDR78    DNAI2

    Find genes that share paralogs with DNAI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAI1 (see all 1253)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0167754
    Kartagener syndrome (KTGS)4--see VAR_0167752 G S mis40--------
    rs798334501,2
    Cpathogenic134481439(+) TAGTGG/AGCACA 2 /S /G mis11Minor allele frequency- A:0.00NA 4552
    rs1487225821,2
    C--34421990(+) ATATA-/TAACCTT 1 -- int10--------
    rs1399993431,2
    --34421999(+) TATAT-/ACAACCT 1 -- int10--------
    rs109721251,2
    C,F,H--34425077(+) TCTACC/TATCCC 1 -- us2k119Minor allele frequency- T:0.10NS EA NA WA 2266
    rs1932153131,2
    --34425140(+) GCTGCC/TGTAAT 1 -- us2k10--------
    rs1116710541,2
    F--34425211(+) CAAGGG/ATAGAC 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1430662401,2
    C--34425673(+) TGATGA/GGGGCT 1 -- us2k10--------
    rs1132329321,2
    F--34425717(+) CGACCT/CCACTT 1 -- us2k12Minor allele frequency- C:0.33CSA 3
    rs1851949791,2
    --34425894(+) CTCGCC/TCCGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAI1 (34457412 - 34520982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DNAI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831543CNV Loss17160897
    nsv831542CNV Gain17160897
    nsv893037CNV Gain21882294

    Human Gene Mutation Database (HGMD): DNAI1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAI1
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604366   
    OMIM disorders: 244400  
    UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46
  • Ciliary dyskinesia, primary, 1 (CILD1) [MIM:244400]: A disorder characterized by abnormalities of motile
    cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in
    the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails.
    Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of
    monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as
    Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Kartagener syndrome (KTGS) [MIM:244400]: An autosomal recessive disorder characterized by the association
    of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections,
    bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs
    inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated
    transposition of abdominal viscera). Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 7 diseases for DNAI1:    
    About MalaCards
    kartagener syndrome    ciliary dyskinesia, primary, 1, with or without situs inversus    primary ciliary dyskinesia 1: dnai1-related primary ciliary dyskinesia    situs inversus
    primary ciliary dyskinesia    proximal spinal muscular atrophy    ciliary dyskinesia, primary, 19

    3 diseases from the University of Copenhagen DISEASES database for DNAI1:
    Primary ciliary dyskinesia     Situs inversus     Bronchiectasis

    Find genes that share disorders with DNAI1           About GenesLikeMe

    3 Novoseek inferred disease relationships for DNAI1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kartagener syndrome 88.1 1 11231901 (1)
    situs inversus 85.1 3 11231901 (3)
    retinitis pigmentosa 61.2 1 19410201 (1)

    GeneTests: DNAI1
    GeneReviews: DNAI1
    Genetic Association Database (GAD): DNAI1
    Human Genome Epidemiology (HuGE) Navigator: DNAI1 (4 documents)

    Export disorders for DNAI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for DNAI1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with DNAI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia. (PubMed id 10577904)1, 2, 3 Pennarun G.... Duriez B. (Am. J. Hum. Genet. 1999)
    2. Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). (PubMed id 11231901)1, 2, 9 Guichard C.... Bouvagnet P. (Am. J. Hum. Genet. 2001)
    3. Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. (PubMed id 18492703)1, 4, 9 Zuccarello D....Foresta C. (Hum. Reprod. 2008)
    4. A unified taxonomy for ciliary dyneins. (PubMed id 21953912)1, 3 Hom E.F....King S.M. (Cytoskeleton (Hoboken) 2011)
    5. Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD). (PubMed id 21143860)1, 4 ZiA9tkiewicz E....Witt M. (Respir. Res. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin- containing protein/p97 during capacitation. (PubMed id 12509440)1, 2 Ficarro S....Visconti P.E. (J. Biol. Chem. 2003)
    10. DNAI1 mutations explain only 2% of primary ciliary dykinesia. (PubMed id 18434704)1, 9 Failly M....Blouin J.L. ( international review of thoracic diseases 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 27019 HGNC: 2954 AceView: DNAI1 Ensembl:ENSG00000122735 euGenes: HUgn27019
    ECgene: DNAI1 Kegg: 27019 H-InvDB: DNAI1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAI1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=DNAI1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNAI1 gene:
    Search GeneIP for patents involving DNAI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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