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Aliases for DNAI1 Gene

Aliases for DNAI1 Gene

  • Dynein Axonemal Intermediate Chain 1 2 3
  • Dynein, Axonemal, Intermediate Polypeptide 1 2 3
  • Dynein, Axonemal, Intermediate Chain 1 3 5
  • Testis Tissue Sperm-Binding Protein Li 87P 3
  • Axonemal Dynein Intermediate Chain 1 4
  • Immotile Cilia Syndrome 1 3
  • CILD1 3
  • DIC1 3
  • ICS1 3
  • PCD 3

External Ids for DNAI1 Gene

Previous GeneCards Identifiers for DNAI1 Gene

  • GC09P034771
  • GC09P034628

Summaries for DNAI1 Gene

Entrez Gene Summary for DNAI1 Gene

  • This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for DNAI1 Gene

DNAI1 (Dynein Axonemal Intermediate Chain 1) is a Protein Coding gene. Diseases associated with DNAI1 include Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus and Kartagener Syndrome. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include motor activity. An important paralog of this gene is WDR78.

UniProtKB/Swiss-Prot for DNAI1 Gene

  • Part of the dynein complex of respiratory cilia.

Gene Wiki entry for DNAI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAI1 Gene

Genomics for DNAI1 Gene

Regulatory Elements for DNAI1 Gene

Enhancers for DNAI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAI1 on UCSC Golden Path with GeneCards custom track

Promoters for DNAI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAI1 Gene

34,457,414 bp from pter
34,520,989 bp from pter
63,576 bases
Plus strand

Genomic View for DNAI1 Gene

Genes around DNAI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAI1 Gene

Proteins for DNAI1 Gene

  • Protein details for DNAI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynein intermediate chain 1, axonemal
    Protein Accession:
    Secondary Accessions:
    • B7Z7U1
    • Q5T8G7
    • Q8NHQ7
    • Q9UEZ8

    Protein attributes for DNAI1 Gene

    699 amino acids
    Molecular mass:
    79283 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2.

    Alternative splice isoforms for DNAI1 Gene


neXtProt entry for DNAI1 Gene

Proteomics data for DNAI1 Gene at MOPED

Post-translational modifications for DNAI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAI1 Gene

No data available for DME Specific Peptides for DNAI1 Gene

Domains & Families for DNAI1 Gene

Gene Families for DNAI1 Gene

Protein Domains for DNAI1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynein intermediate chain family.
  • Contains 7 WD repeats.
  • Belongs to the dynein intermediate chain family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DNAI1: view

Function for DNAI1 Gene

Molecular function for DNAI1 Gene

GENATLAS Biochemistry:
dynein axonemal motor protein intermediate chain,homolog of the Chlamydomonas reinhardtii gene IC78 which mutations are associated with the absence of outer dynein arms
UniProtKB/Swiss-Prot Function:
Part of the dynein complex of respiratory cilia.
genes like me logo Genes that share phenotypes with DNAI1: view

Human Phenotype Ontology for DNAI1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DNAI1 Gene

MGI Knock Outs for DNAI1:

Animal Model Products

miRNA for DNAI1 Gene

miRTarBase miRNAs that target DNAI1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DNAI1 Gene

Localization for DNAI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAI1 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

Jensen Localization Image for DNAI1 Gene COMPARTMENTS Subcellular localization image for DNAI1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for DNAI1 Gene

Pathways & Interactions for DNAI1 Gene

genes like me logo Genes that share pathways with DNAI1: view

Pathways by source for DNAI1 Gene

1 KEGG pathway for DNAI1 Gene

Gene Ontology (GO) - Biological Process for DNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
GO:0030317 sperm motility IMP 11231901
genes like me logo Genes that share ontologies with DNAI1: view

No data available for SIGNOR curated interactions for DNAI1 Gene

Drugs & Compounds for DNAI1 Gene

(1) Drugs for DNAI1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DNAI1: view

Transcripts for DNAI1 Gene

Unigene Clusters for DNAI1 Gene

Dynein, axonemal, intermediate chain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAI1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - -
SP2: -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: - - - - - - - - - - - - -
SP8: - - - - -
SP9: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: -

Relevant External Links for DNAI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAI1 Gene

mRNA expression in normal human tissues for DNAI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAI1 Gene

This gene is overexpressed in Testis (x15.2), Pituitary (x10.3), and Fallopian Tube (x5.2).

Protein differential expression in normal tissues from HIPED for DNAI1 Gene

This gene is overexpressed in Testis (49.5) and Ovary (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAI1 Gene

SOURCE GeneReport for Unigene cluster for DNAI1 Gene Hs.112667

genes like me logo Genes that share expression patterns with DNAI1: view

Protein tissue co-expression partners for DNAI1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DNAI1 Gene

Orthologs for DNAI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAI1 35
  • 87.97 (n)
  • 87.39 (a)
DNAI1 36
  • 88 (a)
(Canis familiaris)
Mammalia DNAI1 35
  • 89.8 (n)
  • 87.99 (a)
DNAI1 36
  • 88 (a)
(Mus musculus)
Mammalia Dnaic1 35
  • 87.51 (n)
  • 88.57 (a)
Dnaic1 16
Dnaic1 36
  • 88 (a)
(Pan troglodytes)
Mammalia DNAI1 35
  • 99.28 (n)
  • 98.86 (a)
DNAI1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dnai1 35
  • 86.25 (n)
  • 86.25 (a)
(Monodelphis domestica)
Mammalia DNAI1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia DNAI1 36
  • 67 (a)
(Gallus gallus)
Aves DNAI1 35
  • 72.19 (n)
  • 70.86 (a)
DNAI1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia DNAI1 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17724 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16599 35
(Danio rerio)
Actinopterygii Dr.15508 35
zgc:158666 35
  • 67.2 (n)
  • 62.5 (a)
dnai1 36
  • 50 (a)
DNAI1 (1 of 2) 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7051 37
  • 27 (a)
CG9313 37
  • 48 (a)
CG9313 35
  • 55.36 (n)
  • 45.61 (a)
CG9313 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008689 35
  • 28.22 (n)
  • 10.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4155 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for DNAI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAI1 Gene

Gene Tree for DNAI1 (if available)
Gene Tree for DNAI1 (if available)

Paralogs for DNAI1 Gene

Paralogs for DNAI1 Gene

(2) SIMAP similar genes for DNAI1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNAI1: view

Variants for DNAI1 Gene

Sequence variations from dbSNP and Humsavar for DNAI1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_016774 -
VAR_016775 Kartagener syndrome (KTGS)
rs16931549 - 34,485,239(+) CGATG(C/T)GGTGA nc-transcript-variant, reference, missense
rs16931555 - 34,500,798(+) TTCCA(A/C)AATGA nc-transcript-variant, reference, missense
rs11793196 - 34,500,823(+) TGTCC(A/G/T)TCACT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNAI1 Gene

Variant ID Type Subtype PubMed ID
nsv893037 CNV Gain 21882294
nsv831542 CNV Gain 17160897
nsv831543 CNV Loss 17160897

Variation tolerance for DNAI1 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAI1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAI1 Gene

Disorders for DNAI1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for DNAI1 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DNAI1 in MalaCards View complete list of genes associated with diseases


  • Ciliary dyskinesia, primary, 1 (CILD1) [MIM:244400]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269 PubMed:25186273}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Kartagener syndrome (KTGS) [MIM:244400]: An autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). {ECO:0000269 PubMed:11231901}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNAI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAI1: view

No data available for Genatlas for DNAI1 Gene

Publications for DNAI1 Gene

  1. Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia. (PMID: 10577904) Pennarun G. … Duriez B. (Am. J. Hum. Genet. 1999) 2 3 4 67
  2. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 3
  3. DNAI1 mutations explain only 2% of primary ciliary dykinesia. (PMID: 18434704) Failly M. … Blouin J.L. (Respiration 2008) 3 23
  4. Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. (PMID: 18492703) Zuccarello D. … Foresta C. (Hum. Reprod. 2008) 3 23
  5. DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm. (PMID: 18950741) Loges N.T. … Omran H. (Am. J. Hum. Genet. 2008) 3 23

Products for DNAI1 Gene

Sources for DNAI1 Gene