DNAI1 Gene
protein-coding GIFtS: 59
GCID: GC09P034448
|
|
dynein, axonemal, intermediate chain 1(Previous names: dynein, axonemal, intermediate polypeptide 1 )
| |
Aliases
for DNAI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dynein, Axonemal, Intermediate Chain 11 2 | | ICS2 5 | | CILD11 2 5 | | ICS12 | | PCD1 2 5 | | Dynein Intermediate Chain 1, Axonemal2 | | DIC11 2 | | Dynein Intermediate Chain DNAI12 | | Dynein, Axonemal, Intermediate Polypeptide 11 2 | | Immotile Cilia Syndrome 12 | | Axonemal Dynein Intermediate Chain 12 3 | | |
Export aliases for DNAI1 gene to outside databasesPrevious GC identifers: GC09P034771 GC09P034628 |
Summaries
for DNAI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DNAI1:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generatingproteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the baseof the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodesan intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result inabnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46Function: Part of the dynein complex of respiratory cilia
Gene Wiki entry for DNAI1
|
Genomic Views
for DNAI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAI1 gene promoter:
Brachyury E47 C/EBPalpha MZF-1 CHOP-10 POU2F1 FOXC1 POU2F1b c-Myb Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAI1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAI1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3DNAI1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P034448: view genomic region
(about GC identifiers)
Start:
|
34,457,412 bp from pter |
End:
|
34,520,982 bp from pter |
Size:
|
63,571 bases |
Orientation:
|
plus strand |
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Proteins
for DNAI1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46 (See
protein sequence)Recommended Name: Dynein intermediate chain 1, axonemal Size: 699 amino acids; 79283 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme
Secondary accessions: Q5T8G7 Q8NHQ7 Q9UEZ8Explore the universe of human proteins at neXtProt for DNAI1: NX_Q9UI46
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UI46
DNAI1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036276.1
ENSEMBL proteins: ENSP00000242317 ENSP00000395396 ENSP00000434296 ENSP00000408129 ENSP00000443667
Human Recombinant Protein Products for DNAI1:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
DNAI1 for ontologies About GeneDecksing
DNAI1 Antibody Products:
Assay Products for DNAI1: |
Protein
Domains /
Families
for DNAI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAI1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UI46ProtoNet protein and cluster: Q9UI46 UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46Similarity: Belongs to the dynein intermediate chain familySimilarity: Contains 5 WD repeats |
Function
for DNAI1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DNAI1_HUMAN, Q9UI46Function: Part of the dynein complex of respiratory cilia Genatlas biochemistry entry for DNAI1:dynein axonemal motor protein intermediate chain,homolog of the Chlamydomonas reinhardtii gene IC78 which mutations areassociated with the absence of outer dynein arms
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003774 | motor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
DNAI1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DNAI1:
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Dnaic1):
DNAI1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Dnaic1tm1.2Leo for DNAI1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAI1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAI1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAI1 (NM_012144) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAI1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAI1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAI1 |
|
Pathways & Interactions
for DNAI1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Cytoskeleton remodeling Neurofilaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DNAI1
1 
Kegg Pathway (Kegg details for DNAI1):
DNAI1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAI1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/37 Interacting proteins for DNAI1 (Q9UI463 ENSP000002423174) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003351 | epithelial cilium movement |
IEA | -- | | GO:0030030 | cell projection organization |
IEA | -- |
DNAI1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DNAI1 for compounds About GeneDecksing
 Browse Tocris compounds for DNAI1
1 Novoseek chemical compound relationship for DNAI1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| salicylic acid |
38.8 |
5 |
17588170 (4), 12848825 (1) |
Search CenterWatch for drugs/clinical trials and news about DNAI1
|
Transcripts
for DNAI1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAI1 gene: NM_012144.2 Unigene Cluster for DNAI1: Dynein, axonemal, intermediate chain 1 Hs.112667 [show with all ESTs]Unigene Representative Sequence: NM_0121449 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000470982 ENST00000242317(uc003zum.3) ENST00000437363 ENST00000488369
ENST00000488790 ENST00000470169 ENST00000442556 ENST00000485580 ENST00000545019(uc011lom.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAI1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAI1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAI1 (NM_012144) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAI1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAI1 |
Additional cDNA sequence: AF091619.1 AK290696.1 AK302186.1 AK302499.1 AK303937.1 AK314639.1 BC030583.2 7 DOTS entries: DT.200184 DT.300778 DT.92417933 DT.121166130 DT.97767548 DT.97775490 DT.95084076 24/55 AceView cDNA sequences (see all 55): AI306488 BE348313 AI953703 AL117535 BM713632 AF091619 AW025946 NM_012144 AA609218 BE504837 BX114274 AI018373 BM127557 BM554168 AI628873 BM127260 BI766430 BC030583 BM921065 BM013886 AA923458 BE550140 AI306489 AW594489
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DNAI1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNAI1
|
Expression
for DNAI1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DNAI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAI1
SOURCE GeneReport for Unigene cluster: Hs.112667
SABiosciences Custom PCR Arrays for DNAI1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAI1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAI1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAI1 |
Orthologs
for DNAI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DNAI1 gene from 5/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DNAI11 |
dynein, axonemal, intermediate chain 1 |
72.3(n)
70.77(a) |
|
431654 XM_003642965.1 XP_003643013.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DNAI16 |
-- |
81(a) |
1 ↔ 1 |
GL343482.1(244584-309813) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.165992 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.53(n) |
|
CF288469.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.155082 |
Transcribed sequence with weak similarity to protein more |
79.2(n) |
|
BM317298.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG93131 , 3 |
microtubule-based movement dynein ATPase3
CG93131 |
48(a)
(best of 2)3
56.37(n)1
47.23(a)1 |
|
57B53
373741 NM_137686.51 NP_611530.51 |
ENSEMBL Gene Tree for DNAI1 (if available)
TreeFam Gene Tree for DNAI1 (if available) |
Paralogs
for DNAI1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DNAI1 gene
- WDR632 DNAI22 DYNC1I12 WDR342 DYNC1I22 WDR782
2 SIMAP similar genes for DNAI1 using alignment to 5 protein entries: DNAI1_HUMAN (see all proteins):WDR78 DNAI2
DNAI1 for paralogs About GeneDecksing
|
Genomic Variants
for DNAI1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAI1 (34457412 - 34520982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNAI1: --
Human Gene Mutation Database (HGMD): DNAI1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAI1 |
|
Disorders
/ Diseases
for DNAI1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAI1 for disorders About GeneDecksing
OMIM gene information: 604366
OMIM disorders: 244400
UniProtKB/Swiss-Prot: DNAI1_HUMAN, Q9UI46
Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is anautosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leadingto chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertilityis often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus,due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliarydyskinesia associated with situs inversus is referred to as Kartagener syndrome Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessivedisorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features includerecurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thoraxand abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardiaor isolated transposition of abdominal viscera)
11  diseases for DNAI1: About MalaCardsciliary dyskinesia, primary, 1, with our without situs inversus ciliary dyskinesia primary ciliary dyskinesia kartagener syndrome
situs inversus retinitis pigmentosa dextrocardia bronchiectasis
huntington's disease retinitis malaria
4 diseases from the University of Copenhagen DISEASES database for DNAI1:Primary ciliary dyskinesia Situs inversus Bronchiectasis Male infertility 3 Novoseek disease relationships for DNAI1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| kartagener syndrome |
88.1 |
1 |
11231901 (1) |
| situs inversus |
85.1 |
3 |
11231901 (3) |
| retinitis pigmentosa |
61.2 |
1 |
19410201 (1) |
GeneTests: DNAI1
Primary Ciliary Dyskinesia
Human Genome Epidemiology (HuGE) Navigator: DNAI1 (4 documents)
Export disorders for DNAI1 gene to outside databases
|
Publications
for DNAI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAI1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with DNAI1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia. (PubMed id 10577904)1, 2, 3 Pennarun G.... Duriez B. (1999)
- Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). (PubMed id 11231901)1, 2, 9 Guichard C.... Bouvagnet P. (2001)
- A unified taxonomy for ciliary dyneins. (PubMed id 21953912)1, 3 Hom E.F....King S.M. (2011)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNAI1 mutations explain only 2% of primary ciliary dykinesia. (PubMed id 18434704)1, 9 Failly M....Blouin J.L. (2008)
- Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia. (PubMed id 11713099)1, 9 Zariwala M....Knowles M.R. (2001)
- Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. (PubMed id 18492703)1, 9 Zuccarello D....Foresta C. (2008)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Population specificity of the DNAI1 gene mutation spe ctrum in primary ciliary dyskinesia (PCD). (PubMed id 21143860)1 ZiA9tkiewicz E....Witt M. (2010)
|
External Searches for DNAI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNAI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAI1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAI1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DNAI1 |
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About This Section
| Patent Information for DNAI1 gene:
Search GeneIP for patents involving DNAI1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DNAI1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAI1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAI1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAI1 | | | OriGene Protein Over-expression Lysate for DNAI1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAI1 | | OriGene 3'-UTR Clone for DNAI1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAI1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAI1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DNAI1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAI1 | | OriGene Custom Protein Services for DNAI1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAI1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAI1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAI1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAI1 |
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| | | | Search Tocris compounds for DNAI1 |
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 | | | DNAI1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAI1 |
|  |  |  |  | | | | ThermoFisher Antibodies for DNAI1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAI1 |
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