Aliases for DNAI1 Gene
External Ids for DNAI1 Gene
Previous GeneCards Identifiers for DNAI1 Gene
This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for DNAI1 Gene
DNAI1 (Dynein, Axonemal, Intermediate Chain 1) is a Protein Coding gene. Diseases associated with DNAI1 include ciliary dyskinesia, primary, 1, with or without situs inversus and primary ciliary dyskinesia. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include motor activity. An important paralog of this gene is WDR78.
UniProtKB/Swiss-Prot for DNAI1 Gene
Part of the dynein complex of respiratory cilia