Aliases for DNAH8 Gene
External Ids for DNAH8 Gene
Previous GeneCards Identifiers for DNAH8 Gene
The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
GeneCards Summary for DNAH8 Gene
DNAH8 (Dynein Axonemal Heavy Chain 8) is a Protein Coding gene. Diseases associated with DNAH8 include Colchicine Resistance and Mitochondrial Complex V Deficiency, Nuclear Type 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH5.
UniProtKB/Swiss-Prot for DNAH8 Gene
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).