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DNAH7 Gene

protein-coding   GIFtS: 54
GCID: GC02M196602

Dynein, Axonemal, Heavy Chain 7

(Previous names: dynein, axonemal, heavy polypeptide 7)
  Search for DNAH7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Heavy Chain 71 2     hDHC22 3
Dynein, Axonemal, Heavy Polypeptide 71 2     KIAA09443 5
Axonemal Beta Dynein Heavy Chain 72 3     Axonemal Dynein Heavy Chain 72
Ciliary Dynein Heavy Chain 72 3     Dynein Heavy Chain 7, Axonemal2
Dynein Heavy Chain-Like Protein 22 3     

External Ids:    HGNC: 186611   Entrez Gene: 561712   Ensembl: ENSG000001189977   OMIM: 6100615   UniProtKB: Q8WXX03   

Export aliases for DNAH7 gene to outside databases

Previous GC identifers: GC02M194792 GC02M195315 GC02M196566 GC02M196804 GC02M196427 GC02M196310 GC02M188455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAH7 Gene:
DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 (PubMed 11877439)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for DNAH7 Gene:
DNAH7 (dynein, axonemal, heavy chain 7) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity and calcium ion binding. An important paralog of this gene is DNAH5.

UniProtKB/Swiss-Prot: DYH7_HUMAN, Q8WXX0
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAH7 gene promoter:
         Nkx3-1   AML1a   FOXD3   Nkx3-1 v1   CUTL1   Nkx3-1 v2   c-Rel   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAH7 promoter sequence
   Search Chromatin IP Primers for DNAH7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAH7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q33.1

DNAH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAH7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M196602:  view genomic region     (about GC identifiers)

Start:
196,602,427 bp from pter      End:
196,933,536 bp from pter
Size:
331,110 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYH7_HUMAN, Q8WXX0 (See protein sequence)
Recommended Name: Dynein heavy chain 7, axonemal  
Size: 4024 amino acids; 461159 Da
Subunit: The dynein complex consists of at least two heavy chains and a number of intermediate and light chains
(By similarity)
Sequence caution: Sequence=BAA76788.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB06055.1; Type=Frameshift; Positions=1502; Sequence=CAH18445.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAH18445.1; Type=Erroneous translation; Note=Wrong choice of
CDS;
Secondary accessions: B8ZZX8 O00433 O95492 Q4G152 Q53QX7 Q53S64 Q53T02 Q68CY5 Q8N1Z2 Q9UMS3
Q9Y2F3
Alternative splicing: 4 isoforms:  Q8WXX0-1   Q8WXX0-2   Q8WXX0-3   Q8WXX0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAH7: NX_Q8WXX0

Explore proteomics data for DNAH7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAH7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061720.2  
    ENSEMBL proteins: 
     ENSP00000386912   ENSP00000311273   ENSP00000409732   ENSP00000386260   ENSP00000407444  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    DN: Axonemal dyneins

    Selected InterPro protein domains (see all 10):
     IPR004273 Dynein_heavy_dom
     IPR002048 EF_hand_dom
     IPR024317 Dynein_heavy_chain_D4_dom
     IPR024743 Dynein_HC_stalk
     IPR013602 Dynein_heavy_dom-2

    Graphical View of Domain Structure for InterPro Entry Q8WXX0

    ProtoNet protein and cluster: Q8WXX0

    3 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB004273 Dynein heavy chain
    IPB011704 ATPase associated with various cellular activities


    UniProtKB/Swiss-Prot: DYH7_HUMAN, Q8WXX0
    Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other
    dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head,
    which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and
    AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not
    clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two
    non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes
    ATP, the others may serve a regulatory function (By similarity)
    Similarity: Belongs to the dynein heavy chain family


    Find genes that share domains with DNAH7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYH7_HUMAN, Q8WXX0
    Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
    Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By
    similarity)
    Induction: Up-regulated during ciliogenesis (at protein level)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003777microtubule motor activity NAS9373155
    GO:0005509calcium ion binding IEA--
    GO:0005524ATP binding IEA--
    GO:00083127S RNA binding ----
         
    Find genes that share ontologies with DNAH7           About GenesLikeMe


    Animal Models:
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    2 qRT-PCR Assays for microRNAs that regulate DNAH7:
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    SwitchGear 3'UTR luciferase reporter plasmidDNAH7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYH7_HUMAN, Q8WXX0: Cytoplasm, cytoskeleton, cilium axoneme
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005858axonemal dynein complex NAS9373155
    GO:0005874microtubule IEA--
    GO:0005929cilium IDA11877439
    GO:0030286dynein complex ----
    GO:0048500signal recognition particle ----

    Find genes that share ontologies with DNAH7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAH7 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAH7
    Interactions:

        Search GeneGlobe Interaction Network for DNAH7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAH7 (Q8WXX02, 3 ENSP000003112734) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605203, ENSP000000372434I2D: score=1 STRING: ENSP00000037243
    DNAH1ENSP000004015144STRING: ENSP00000401514
    DNAH17ENSP000003744904STRING: ENSP00000374490
    DNAH2ENSP000003738254STRING: ENSP00000373825
    DNAH8ENSP000003523124STRING: ENSP00000352312
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539cilium or flagellum-dependent cell motility NAS9373155
    GO:0006614SRP-dependent cotranslational protein targeting to membrane ----
    GO:0007018microtubule-based movement IEA--
    GO:0008152metabolic process NAS9373155

    Find genes that share ontologies with DNAH7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAH7 (DYH7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAH7 gene: 
    NM_018897.2  

    Unigene Cluster for DNAH7:

    Dynein, axonemal, heavy chain 7
    Hs.97403  [show with all ESTs]
    Unigene Representative Sequence: AB023161
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409063(uc002uti.4) ENST00000312428(uc002utj.4) ENST00000484183
    ENST00000438565 ENST00000493844 ENST00000475293 ENST00000410072 ENST00000427816

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DNAH7:
    hsa-miR-205* hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidDNAH7 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB023161.2 AF327442.1 AJ132084.1 AK094515.1 BC029567.1 CR749651.1 Z83801.1 

    7 DOTS entries:

    DT.208557  DT.95365314  DT.99933157  DT.100663598  DT.91996126  DT.92420015  DT.95193339 

    Selected AceView cDNA sequences (see all 40):

    AF327442 AI866330 BP368825 NM_018897 AB023161 BX503613 BX479352 AA382623 
    BX503614 AV729438 BC029567 CB047657 AK094515 AV728842 BG216298 BG204650 
    AI241846 BG772885 CR749651 AA393310 AL599611 AA766761 BM983036 AA398599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAH7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTTCCCT
    DNAH7 Expression
    About this image


    DNAH7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DNAH7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAH7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97403

    UniProtKB/Swiss-Prot: DYH7_HUMAN, Q8WXX0
    Tissue specificity: Detected in brain, testis and trachea. Detected in bronchial cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAH7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnahc7a5
    Dnah7b1
    dynein, axonemal, heavy chain 7A5
    dynein, axonemal, heavy chain 7B1
    85.08(n)1
    88.87(a)1
      1 (26.99 cM)5
    2270581  NM_001160386.11  NP_001153858.11 
     533970025 
    chicken
    (Gallus gallus)
    Aves DNAH71 dynein, axonemal, heavy chain 7 75.52(n)
    78.09(a)
      424048  XM_003641574.2  XP_003641622.2 
    lizard
    (Anolis carolinensis)
    Reptilia DNAH76
    dynein, axonemal, heavy chain 7
    82(a)
    1 ↔ 1
    GL343280.1(910044-1102279)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnah71 dynein, axonemal, heavy chain 7 74.25(n)
    78.97(a)
      100495128  XM_002937720.2  XP_002937766.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dnah71 dynein, axonemal, heavy chain 7 68.08(n)
    73.15(a)
      561639  XM_685051.4  XP_690143.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dhc36C1 , 3 microtubule-based movement dynein
    ATPase3
    Dynein heavy chain at 36C1
    56(a)
    (best of 5)3
    56.92(n)1
    57.23(a)1
      2 36C103
    350611  NM_078867.31  NP_523591.21 


    ENSEMBL Gene Tree for DNAH7 (if available)
    TreeFam Gene Tree for DNAH7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAH7 gene
    DNAH52  DNAH22  DYNC1H12  DNAH82  DYNC2H12  DNAH92  DNAH32  DNAH112  
    DNAH62  DNAH12  DNAH102  DNAH172  
    11 SIMAP similar genes for DNAH7 using alignment to 3 protein entries:     DYH7_HUMAN (see all proteins):
    DNAH3    DNAH12    DNAH1    DNAH2    DNAH6    DNAH10
    DNAH17    DNAH11    DNAH5    DNAH8    DNAH9

    Find genes that share paralogs with DNAH7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAH7 (see all 6542)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766321281,2
    C,Funtested1196664077(+) AGCACG/AAAAAT 2 /F syn11Minor allele frequency- A:0.04EA 120
    rs1492126591,2
    Cuntested1196746611(+) GTATCG/AAATTG 2 /R /* stg11Minor allele frequency- A:0.00EU 1323
    rs775703411,2
    F--196603039(+) AAAAAT/CAGTTT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs106575331,2
    C--196603136(+) ATGAT-/A/A   
       A
    /AAA
    AAAAA
    2 -- int1 cds11CSA 2
    rs1500162371,2
    C--196603451(+) TTTGA-/TCTT  
            
    TCTTT
    1 -- int10--------
    rs1449785451,2
    --196603510(+) TAATTC/TAATTT 1 -- int10--------
    rs1864356061,2
    --196603555(+) GATGAC/TAGGAC 1 -- int10--------
    rs1152043511,2
    F--196603655(+) TATTTC/TTCCCA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs168393721,2
    C,F--196603797(+) AGAATT/GTTTAT 1 -- int18Minor allele frequency- G:0.17NA WA CSA 380
    rs1476005951,2
    C--196603825(+) TTCAGA/GAGAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNAH7 (196602427 - 196852427 bp, first 250kb of DNAH7)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DNAH7 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721333CNV Deletion23290073
    esv2233474CNV Deletion18987734
    esv3418CNV Deletion18987735
    esv2489659CNV Deletion19546169
    esv2721334CNV Deletion23290073
    esv2580785CNV Deletion19546169
    esv2721332CNV Deletion23290073
    esv2721331CNV Deletion23290073
    esv2215403CNV Deletion18987734
    esv2662087CNV Deletion23128226

    Human Gene Mutation Database (HGMD): DNAH7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAH7
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAH7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610061    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DNAH7:
    Primary ciliary dyskinesia

    Find genes that share disorders with DNAH7           About GenesLikeMe

    Genetic Association Database (GAD): DNAH7
    Human Genome Epidemiology (HuGE) Navigator: DNAH7 (1 document)

    Export disorders for DNAH7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAH7 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DNAH7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia. (PubMed id 11877439)1, 2, 3 Zhang Y.J.... Ostrowski L.E. (J. Biol. Chem. 2002)
    2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PubMed id 9373155)1, 2, 3 Neesen J.... Schmid M. (Gene 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56171 HGNC: 18661 AceView: DNAH7 Ensembl:ENSG00000118997 euGenes: HUgn56171
    ECgene: DNAH7 H-InvDB: DNAH7

    (According to HUGE)
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    HUGE: KIAA0944

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAH7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAH7 gene:
    Search GeneIP for patents involving DNAH7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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