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Aliases for DNAH7 Gene

Aliases for DNAH7 Gene

  • Dynein, Axonemal, Heavy Chain 7 2 3
  • Dynein, Axonemal, Heavy Polypeptide 7 2 3
  • Axonemal Beta Dynein Heavy Chain 7 3 4
  • Dynein Heavy Chain-Like Protein 2 3 4
  • Ciliary Dynein Heavy Chain 7 3 4
  • KIAA0944 4 6
  • HDHC2 3 4
  • Dynein Heavy Chain 7, Axonemal 3
  • Axonemal Dynein Heavy Chain 7 3

External Ids for DNAH7 Gene

Previous GeneCards Identifiers for DNAH7 Gene

  • GC02M194792
  • GC02M195315
  • GC02M196566
  • GC02M196804
  • GC02M196427
  • GC02M196310
  • GC02M196602
  • GC02M188455

Summaries for DNAH7 Gene

Entrez Gene Summary for DNAH7 Gene

  • DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAH7 Gene

DNAH7 (Dynein, Axonemal, Heavy Chain 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and microtubule motor activity. An important paralog of this gene is DNAH1.

UniProtKB/Swiss-Prot for DNAH7 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAH7 Gene

Genomics for DNAH7 Gene

Regulatory Elements for DNAH7 Gene

Genomic Location for DNAH7 Gene

Start:
195,737,703 bp from pter
End:
196,068,812 bp from pter
Size:
331,110 bases
Orientation:
Minus strand

Genomic View for DNAH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAH7 Gene

Proteins for DNAH7 Gene

  • Protein details for DNAH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXX0-DYH7_HUMAN
    Recommended name:
    Dynein heavy chain 7, axonemal
    Protein Accession:
    Q8WXX0
    Secondary Accessions:
    • B8ZZX8
    • O00433
    • O95492
    • Q4G152
    • Q53QX7
    • Q53S64
    • Q53T02
    • Q68CY5
    • Q8N1Z2
    • Q9UMS3
    • Q9Y2F3

    Protein attributes for DNAH7 Gene

    Size:
    4024 amino acids
    Molecular mass:
    461159 Da
    Quaternary structure:
    • The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.
    SequenceCaution:
    • Sequence=BAA76788.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB06055.1; Type=Frameshift; Positions=1502; Evidence={ECO:0000305}; Sequence=CAH18445.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18445.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAH7 Gene

Proteomics data for DNAH7 Gene at MOPED

Post-translational modifications for DNAH7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAH7 Gene

No data available for DME Specific Peptides for DNAH7 Gene

Domains for DNAH7 Gene

Gene Families for DNAH7 Gene

HGNC:
  • DN :Axonemal dyneins
  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for DNAH7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXX0

UniProtKB/Swiss-Prot:

DYH7_HUMAN :
  • Q8WXX0
Domain:
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).
Family:
  • Belongs to the dynein heavy chain family.
genes like me logo Genes that share domains with DNAH7: view

Function for DNAH7 Gene

Molecular function for DNAH7 Gene

UniProtKB/Swiss-Prot Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated during ciliogenesis (at protein level).

Gene Ontology (GO) - Molecular Function for DNAH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 9373155
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0008312 7S RNA binding --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with DNAH7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAH7 Gene

Localization for DNAH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAH7 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAH7 Gene COMPARTMENTS Subcellular localization image for DNAH7 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DNAH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005858 axonemal dynein complex NAS 9373155
GO:0005874 microtubule IEA --
GO:0005929 cilium IDA 11877439
GO:0030286 dynein complex --
GO:0048500 signal recognition particle --
genes like me logo Genes that share ontologies with DNAH7: view

Pathways for DNAH7 Gene

SuperPathways for DNAH7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001539 cilium or flagellum-dependent cell motility NAS 9373155
GO:0003341 cilium movement IEA --
GO:0006200 obsolete ATP catabolic process --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane --
GO:0007018 microtubule-based movement --
genes like me logo Genes that share ontologies with DNAH7: view

No data available for Pathways by source for DNAH7 Gene

Transcripts for DNAH7 Gene

Unigene Clusters for DNAH7 Gene

Dynein, axonemal, heavy chain 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAH7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNAH7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAH7 Gene

No ASD Table

Relevant External Links for DNAH7 Gene

GeneLoc Exon Structure for
DNAH7
ECgene alternative splicing isoforms for
DNAH7

Expression for DNAH7 Gene

mRNA expression in normal human tissues for DNAH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAH7 Gene

This gene is overexpressed in Testis (5.0), Pituitary (4.6), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAH7 Gene

SOURCE GeneReport for Unigene cluster for DNAH7 Gene Hs.97403

mRNA Expression by UniProt/SwissProt for DNAH7 Gene

Q8WXX0-DYH7_HUMAN
Tissue specificity: Detected in brain, testis and trachea. Detected in bronchial cells (at protein level).
genes like me logo Genes that share expressions with DNAH7: view

In Situ Assay Products

Orthologs for DNAH7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAH7 35
  • 99.49 (n)
  • 99.4 (a)
DNAH7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAH7 35
  • 90.53 (n)
  • 92.27 (a)
DNAH7 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAH7 35
  • 89.4 (n)
  • 91.9 (a)
DNAH7 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnah7a 36
  • 89 (a)
OneToMany
Dnah7b 35
  • 85.08 (n)
  • 88.87 (a)
Dnah7b 36
  • 88 (a)
OneToMany
Dnahc7a 16
oppossum
(Monodelphis domestica)
Mammalia DNAH7 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAH7 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnah7 35
  • 85.96 (n)
  • 90.93 (a)
chicken
(Gallus gallus)
Aves DNAH7 35
  • 75.52 (n)
  • 78.09 (a)
DNAH7 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAH7 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnah7 35
  • 74.25 (n)
  • 78.97 (a)
zebrafish
(Danio rerio)
Actinopterygii dnah7 35
  • 68.08 (n)
  • 73.15 (a)
dnah7 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009568 35
  • 51.18 (n)
  • 49.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dhc36C 35
  • 56.92 (n)
  • 57.23 (a)
Dhc36C 36
  • 55 (a)
OneToOne
Dhc16F 37
  • 36 (a)
Dhc62B 37
  • 42 (a)
Dhc36C 37
  • 56 (a)
Dhc64C 37
  • 27 (a)
kl-2 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea dhc-1 37
  • 26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for DNAH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAH7 Gene

ENSEMBL:
Gene Tree for DNAH7 (if available)
TreeFam:
Gene Tree for DNAH7 (if available)

Paralogs for DNAH7 Gene

Selected SIMAP similar genes for DNAH7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DNAH7: view

Variants for DNAH7 Gene

Sequence variations from dbSNP and Humsavar for DNAH7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs168191 -- 195,915,941(+) TTCCA(C/T)TACTT intron-variant
rs168192 - 195,906,730(-) TTGAC(A/C/G)CCACA missense, reference
rs182916 -- 195,907,541(-) GATCT(A/G)AATTC intron-variant
rs186894 -- 195,918,427(-) tgggt(A/G)aataa intron-variant
rs186895 -- 195,901,785(-) TTTCC(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAH7 Gene

Variant ID Type Subtype PubMed ID
nsv834501 CNV Gain 17160897
nsv3094 CNV Loss 18451855
nsv820276 CNV Loss 19587683
nsv819804 CNV Loss 19587683
esv2721331 CNV Deletion 23290073
nsv875689 CNV Loss 21882294
esv2489659 CNV Deletion 19546169
esv2721332 CNV Deletion 23290073
esv2215403 CNV Deletion 18987734
esv3418 CNV Deletion 18987735
esv2667726 CNV Deletion 23128226
esv2721333 CNV Deletion 23290073
nsv214751 CNV Loss 16902084
nsv875690 CNV Loss 21882294
esv2580785 CNV Deletion 19546169
esv269501 CNV Insertion 20981092
nsv875691 CNV Gain 21882294
esv2233474 CNV Deletion 18987734
esv2721334 CNV Deletion 23290073
esv2662087 CNV Deletion 23128226
nsv875692 CNV Loss 21882294

Relevant External Links for DNAH7 Gene

HapMap Linkage Disequilibrium report
DNAH7
Human Gene Mutation Database (HGMD)
DNAH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAH7 Gene

Disorders for DNAH7 Gene

(1) University of Copenhagen DISEASES for DNAH7 Gene

Relevant External Links for DNAH7

Genetic Association Database (GAD)
DNAH7
Human Genome Epidemiology (HuGE) Navigator
DNAH7
genes like me logo Genes that share disorders with DNAH7: view

No data available for UniProtKB/Swiss-Prot for DNAH7 Gene

Publications for DNAH7 Gene

  1. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PMID: 9373155) Neesen J. … Schmid M. (Gene 1997) 2 3 4
  2. Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia. (PMID: 11877439) Zhang Y.J. … Ostrowski L.E. (J. Biol. Chem. 2002) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for DNAH7 Gene

Sources for DNAH7 Gene

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