Aliases for DNAH6 Gene
External Ids for DNAH6 Gene
Previous HGNC Symbols for DNAH6 Gene
Previous GeneCards Identifiers for DNAH6 Gene
This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]
GeneCards Summary for DNAH6 Gene
DNAH6 (Dynein Axonemal Heavy Chain 6) is a Protein Coding gene. Diseases associated with DNAH6 include Heterotaxy and Primary Ciliary Dyskinesia. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.
UniProtKB/Swiss-Prot for DNAH6 Gene
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).