Aliases for DNAH6 Gene
External Ids for DNAH6 Gene
Previous HGNC Symbols for DNAH6 Gene
Previous GeneCards Identifiers for DNAH6 Gene
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH6 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DNAH6 Gene
DNAH6 (Dynein Axonemal Heavy Chain 6) is a Protein Coding gene. Diseases associated with DNAH6 include primary ciliary dyskinesia. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.
UniProtKB/Swiss-Prot for DNAH6 Gene
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).