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DNAH3 Gene

protein-coding   GIFtS: 50
GCID: GC16M020944

Dynein, Axonemal, Heavy Chain 3

(Previous names: dynein, axonemal, heavy polypeptide 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Heavy Chain 31 2     Hsadhc32
DNAHC3B2 3 5     Axonemal Dynein, Heavy Chain2
Dynein, Axonemal, Heavy Polypeptide 31 2     dnahc3-b2
Axonemal Beta Dynein Heavy Chain 32 3     Dynein Heavy Chain 3, Axonemal2
Ciliary Dynein Heavy Chain 32 3     Epididymis Luminal Protein 362
DLP32     Dnahc3-b3
HEL-362     HsADHC33

External Ids:    HGNC: 29491   Entrez Gene: 555672   Ensembl: ENSG000001584867   OMIM: 6033345   UniProtKB: Q8TD573   

Export aliases for DNAH3 gene to outside databases

Previous GC identifers: GC16U990018 GC16M020871 GC16M020911 GC16M020910 GC16M020851 GC16M019480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAH3 Gene:
DNAH3 (dynein, axonemal, heavy chain 3) is a protein-coding gene. Diseases associated with DNAH3 include appendicitis, and smallpox. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DNAH5.

UniProtKB/Swiss-Prot: DYH3_HUMAN, Q8TD57
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in
sperm motility; implicated in sperm flagellar assembly (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAH3 gene promoter:
         PPAR-gamma1   p53   Brachyury   PPAR-gamma2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAH3 promoter sequence
   Search Chromatin IP Primers for DNAH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.2

DNAH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAH3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M020944:  view genomic region     (about GC identifiers)

Start:
20,944,433 bp from pter      End:
21,170,762 bp from pter
Size:
226,330 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYH3_HUMAN, Q8TD57 (See protein sequence)
Recommended Name: Dynein heavy chain 3, axonemal  
Size: 4116 amino acids; 470771 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Secondary accessions: O00437 O15437 O43326 Q3C0H2 Q8WUP9 Q9UEM3 Q9UEM5 Q9UG35
Alternative splicing: 3 isoforms:  Q8TD57-1   Q8TD57-2   Q8TD57-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAH3: NX_Q8TD57

Explore proteomics data for DNAH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060009.1  
    ENSEMBL proteins: 
     ENSP00000261383   ENSP00000394245  

    DNAH3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for DNAH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DN: Axonemal dyneins

    Selected InterPro protein domains (see all 7):
     IPR004273 Dynein_heavy_dom
     IPR024317 Dynein_heavy_chain_D4_dom
     IPR024743 Dynein_HC_stalk
     IPR013602 Dynein_heavy_dom-2
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8TD57

    ProtoNet protein and cluster: Q8TD57

    2 Blocks protein domains:
    IPB004273 Dynein heavy chain
    IPB011704 ATPase associated with various cellular activities


    UniProtKB/Swiss-Prot: DYH3_HUMAN, Q8TD57
    Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other
    dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head,
    which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and
    AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not
    clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two
    non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes
    ATP, the others may serve a regulatory function (By similarity)
    Similarity: Belongs to the dynein heavy chain family


    DNAH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYH3_HUMAN, Q8TD57
    Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
    Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in
    sperm motility; implicated in sperm flagellar assembly (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003777microtubule motor activity NAS9256245
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity ----
         
    DNAH3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAH3
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    miRNA
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    hsa-mir-148b-3p (MIRT019480), hsa-mir-335-5p (MIRT019204)

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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DNAH3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYH3_HUMAN, Q8TD57: Cytoplasm, cytoskeleton, cilium axoneme (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005858axonemal dynein complex NAS9256245
    GO:0005874microtubule IEA--
    GO:0030286dynein complex ----

    DNAH3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAH3 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNAH3):
        Huntington's disease


    DNAH3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAH3
    Interactions:

        Search GeneGlobe Interaction Network for DNAH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAH3 (Q8TD573 ENSP000002613834) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494073I2D: score=1 
    PXNP490233I2D: score=1 
    DNAH2ENSP000003738254STRING: ENSP00000373825
    DNAH8ENSP000003523124STRING: ENSP00000352312
    DNAH9ENSP000002624424STRING: ENSP00000262442
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539cilium or flagellum-dependent cell motility NAS9256245
    GO:0007018microtubule-based movement IEA--
    GO:0008152metabolic process NAS9256245

    DNAH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAH3 (DYH3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAH3 gene: 
    NM_017539.1  

    Unigene Cluster for DNAH3:

    Dynein, axonemal, heavy chain 3
    Hs.526500  [show with all ESTs]
    Unigene Representative Sequence: AF494040
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261383(uc010vbe.2) ENST00000572640 ENST00000572931 ENST00000396036(uc002die.2)
    ENST00000575024 ENST00000575491 ENST00000415178(uc010vbd.2)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: DNAH3 (NM_017539)
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      QuantiFast Probe-based Assays in human, mouse, rat DNAH3

    Additional mRNA sequence: 

    AF494040.1 AJ132085.1 AK026793.1 AK027211.1 AK056509.2 AK125907.1 AK125952.1 AK303958.1 
    AK310973.1 AL096732.1 BC019878.1 Z83805.1 

    8 DOTS entries:

    DT.91750511  DT.75194177  DT.101967841  DT.101977250  DT.75140601  DT.95241238  DT.97793715  DT.95111172 

    23 AceView cDNA sequences:

    AK125952 AF494040 NM_017539 BM982518 AI223145 BF037266 BC019878 AW138942 
    AK056509 AK125907 AL096732 BX280694 AK026793 BF376586 BU663881 AI963400 
    AW298181 AW072324 AL039584 Z83805 AJ132085 BX101729 AL039583 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DNAH3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:        -                                                                 -                             -           -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                    -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b ^ 47 ^
    SP1:              -                                                                                                           -                       -         
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                                             

    ExUns: 48 ^ 49 ^ 50a · 50b · 50c ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64a · 64b
    SP1:                          -                                                                                                   
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                -                                                                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for DNAH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTCCAGAC
    DNAH3 Expression
    About this image


    DNAH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Atrioventricular Node
    DNAH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526500

    UniProtKB/Swiss-Prot: DYH3_HUMAN, Q8TD57
    Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also
    expressed in lung

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAH3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnahc35
    Dnah31
    dynein, axonemal, heavy chain 31, 5 84.3(n)1
    87.31(a)1
      7 (64.34 cM)5
    3819171  XM_006508416.11  XP_006508479.11 
     1199227175 
    chicken
    (Gallus gallus)
    Aves DNAH31 dynein, axonemal, heavy chain 3 70.74(n)
    74.13(a)
      427004  XM_004945467.1  XP_004945524.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    44(a)
    many ↔ many
    2(163190574-163277762)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnah31 dynein, axonemal, heavy chain 3 70.43(n)
    75.63(a)
      100490919  XM_002931982.2  XP_002932028.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj36g102 Transcribed sequence with moderate similarity to protein more 74.65(n)    BM070951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG171501 CG17150 55.61(n)
    51.11(a)
      38586  NM_139680.3  NP_647937.2 


    ENSEMBL Gene Tree for DNAH3 (if available)
    TreeFam Gene Tree for DNAH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAH3 gene
    DNAH52  DNAH22  DYNC1H12  DNAH82  DYNC2H12  DNAH92  DNAH112  DNAH72  
    DNAH62  DNAH12  DNAH102  DNAH172  
    11 SIMAP similar genes for DNAH3 using alignment to 1 protein entry:     DYH3_HUMAN:
    DNAH5    DNAH7    DNAH1    DNAH2    DNAH6    DNAH17
    DNAH10    DNAH12    DNAH9    DNAH11    DNAH8

    DNAH3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DNAH3
    PGOHUM00000239901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAH3 (see all 5295)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0394124
    A colorectal cancer sample4--see VAR_0394122 I L mis40--------
    VAR_0394164
    A colorectal cancer sample4--see VAR_0394162 S F mis40--------
    rs2014482971,2
    Cuntested121151926(+) ACATCA/C/GAGCTG 2 L syn11EU 1323
    rs1134743421,2
    F--20943978(+) GGGGGA/GGAAGG 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1512429481,2
    --20943981(+) GGGGAA/GGGATA 1 -- ds50010--------
    rs1414766331,2
    C--20943985(+) AAGGAC/TAGCAT 1 -- ds50010--------
    rs1470088221,2
    --20944000(+) AGATAC/TACCTA 1 -- ds50010--------
    rs1476284831,2
    C--20944057(+) TATACA/GTATGT 1 -- ds50010--------
    rs1174177201,2
    C,F--20944185(+) TGGGAG/AGCCAA 1 -- ds50011Minor allele frequency- A:0.06EA 120
    rs127086391,2
    C,F,A--20944193(+) CAAAGG/AGGGAG 1 -- ds50018Minor allele frequency- A:0.28NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for DNAH3 (20944433 - 21170762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DNAH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435666CNV Deletion17901297
    nsv436835CNV Insertion17901297
    nsv819009CNV Loss19587683
    nsv457444CNV Loss19166990
    nsv833166CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAH3
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603334    OMIM disorders: --

    6 diseases for DNAH3:    
    About MalaCards
    appendicitis    smallpox    huntington's disease    breast and colorectal cancer
    colorectal cancer    malaria


    DNAH3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNAH3
    Human Genome Epidemiology (HuGE) Navigator: DNAH3 (1 document)

    Export disorders for DNAH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAH3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DNAH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. (PubMed id 9256245)1, 2, 3 Chapelin C....Amselem S. (FEBS Lett. 1997)
    2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PubMed id 9373155)1, 2, 3 Neesen J.... Schmid M. (Gene 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    6. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    7. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55567 HGNC: 2949 AceView: DNAH3 Ensembl:ENSG00000158486 euGenes: HUgn55567
    ECgene: DNAH3 Kegg: 55567 H-InvDB: DNAH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAH3 gene:
    Search GeneIP for patents involving DNAH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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