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Aliases for DNAH3 Gene

Aliases for DNAH3 Gene

  • Dynein Axonemal Heavy Chain 3 2 3
  • Dynein, Axonemal, Heavy Polypeptide 3 2 3
  • Axonemal Beta Dynein Heavy Chain 3 3 4
  • Dynein, Axonemal, Heavy Chain 3 3 5
  • Ciliary Dynein Heavy Chain 3 3 4
  • Dnahc3-B 3 4
  • Hsadhc3 3 4
  • DNAHC3B 3 4
  • Epididymis Luminal Protein 36 3
  • Axonemal Dynein, Heavy Chain 3
  • HEL-36 3
  • DLP3 3

External Ids for DNAH3 Gene

Previous GeneCards Identifiers for DNAH3 Gene

  • GC16U990018
  • GC16M020871
  • GC16M020911
  • GC16M020910
  • GC16M020851
  • GC16M019480

Summaries for DNAH3 Gene

GeneCards Summary for DNAH3 Gene

DNAH3 (Dynein Axonemal Heavy Chain 3) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.

UniProtKB/Swiss-Prot for DNAH3 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAH3 Gene

Genomics for DNAH3 Gene

Regulatory Elements for DNAH3 Gene

Enhancers for DNAH3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAH3 on UCSC Golden Path with GeneCards custom track

Promoters for DNAH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAH3 Gene

Chromosome:
16
Start:
20,933,111 bp from pter
End:
21,159,441 bp from pter
Size:
226,331 bases
Orientation:
Minus strand

Genomic View for DNAH3 Gene

Genes around DNAH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAH3 Gene

Proteins for DNAH3 Gene

  • Protein details for DNAH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD57-DYH3_HUMAN
    Recommended name:
    Dynein heavy chain 3, axonemal
    Protein Accession:
    Q8TD57
    Secondary Accessions:
    • O00437
    • O15437
    • O43326
    • Q3C0H2
    • Q8WUP9
    • Q9UEM3
    • Q9UEM5
    • Q9UG35

    Protein attributes for DNAH3 Gene

    Size:
    4116 amino acids
    Molecular mass:
    470771 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains.

    Alternative splice isoforms for DNAH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAH3 Gene

Proteomics data for DNAH3 Gene at MOPED

Post-translational modifications for DNAH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAH3 Gene

Domains & Families for DNAH3 Gene

Gene Families for DNAH3 Gene

Suggested Antigen Peptide Sequences for DNAH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD57

UniProtKB/Swiss-Prot:

DYH3_HUMAN :
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).
  • Belongs to the dynein heavy chain family.
Domain:
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).
Family:
  • Belongs to the dynein heavy chain family.
genes like me logo Genes that share domains with DNAH3: view

Function for DNAH3 Gene

Molecular function for DNAH3 Gene

UniProtKB/Swiss-Prot Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
genes like me logo Genes that share phenotypes with DNAH3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAH3 Gene

Localization for DNAH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAH3 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAH3 Gene COMPARTMENTS Subcellular localization image for DNAH3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030286 dynein complex IEA --
genes like me logo Genes that share ontologies with DNAH3: view

Pathways & Interactions for DNAH3 Gene

genes like me logo Genes that share pathways with DNAH3: view

Pathways by source for DNAH3 Gene

1 KEGG pathway for DNAH3 Gene

Interacting Proteins for DNAH3 Gene

Gene Ontology (GO) - Biological Process for DNAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001539 cilium or flagellum-dependent cell motility NAS 9256245
genes like me logo Genes that share ontologies with DNAH3: view

No data available for SIGNOR curated interactions for DNAH3 Gene

Drugs & Compounds for DNAH3 Gene

No Compound Related Data Available

Transcripts for DNAH3 Gene

Unigene Clusters for DNAH3 Gene

Dynein, axonemal, heavy chain 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAH3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -
SP2:
SP3: -
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b ^ 47 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5: -

ExUns: 48 ^ 49 ^ 50a · 50b · 50c ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64a · 64b
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for DNAH3 Gene

GeneLoc Exon Structure for
DNAH3
ECgene alternative splicing isoforms for
DNAH3

Expression for DNAH3 Gene

mRNA expression in normal human tissues for DNAH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAH3 Gene

This gene is overexpressed in Testis (x19.3), Fallopian Tube (x7.9), Cervix - Endocervix (x4.8), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for DNAH3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (46.7) and Cervix (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAH3 Gene



SOURCE GeneReport for Unigene cluster for DNAH3 Gene Hs.526500

mRNA Expression by UniProt/SwissProt for DNAH3 Gene

Q8TD57-DYH3_HUMAN
Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
genes like me logo Genes that share expression patterns with DNAH3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for DNAH3 Gene

Orthologs for DNAH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAH3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DNAH3 35
  • 88.6 (n)
  • 89.75 (a)
DNAH3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnah3 36
  • 87 (a)
OneToOne
Dnah3 16
Dnah3 35
  • 84.3 (n)
  • 87.31 (a)
chimpanzee
(Pan troglodytes)
Mammalia DNAH3 36
  • 99 (a)
OneToOne
DNAH3 35
  • 99.35 (n)
  • 99.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAH3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAH3 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAH3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnah3 35
  • 84.33 (n)
  • 86.99 (a)
chicken
(Gallus gallus)
Aves DNAH3 36
  • 74 (a)
OneToOne
DNAH3 35
  • 70.74 (n)
  • 74.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnah3 35
  • 70.43 (n)
  • 75.63 (a)
zebrafish
(Danio rerio)
Actinopterygii wufj36g10 35
DNAH3 36
  • 70 (a)
OneToOne
si:dkey-161j23.4 35
  • 67.65 (n)
  • 70.5 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002009 35
  • 55.69 (n)
  • 51.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17150 35
  • 55.61 (n)
  • 51.11 (a)
CG17150 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for DNAH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAH3 Gene

ENSEMBL:
Gene Tree for DNAH3 (if available)
TreeFam:
Gene Tree for DNAH3 (if available)

Paralogs for DNAH3 Gene

(11) SIMAP similar genes for DNAH3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DNAH3 Gene

genes like me logo Genes that share paralogs with DNAH3: view

Variants for DNAH3 Gene

Sequence variations from dbSNP and Humsavar for DNAH3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_039412 A colorectal cancer sample
rs16970910 - 21,120,806(+) TTGCC(A/G)ATCAG intron-variant, reference, missense
rs330150 - 21,039,887(+) AGGGA(C/G)ATTTC reference, missense
rs16970832 - 21,037,964(+) CGCAA(C/T)GATCT reference, missense
VAR_039416 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for DNAH3 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv457444 CNV Loss 19166990
nsv833166 CNV Gain+Loss 17160897
nsv819009 CNV Loss 19587683
nsv435666 CNV Deletion 17901297

Variation tolerance for DNAH3 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.55; 99.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAH3 Gene

HapMap Linkage Disequilibrium report
DNAH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAH3 Gene

Disorders for DNAH3 Gene

Relevant External Links for DNAH3

Genetic Association Database (GAD)
DNAH3
Human Genome Epidemiology (HuGE) Navigator
DNAH3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAH3

No disorders were found for DNAH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAH3 Gene

Publications for DNAH3 Gene

  1. Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. (PMID: 9256245) Chapelin C. … Amselem S. (FEBS Lett. 1997) 2 3 4 67
  2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PMID: 9373155) Neesen J. … Schmid M. (Gene 1997) 2 3
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3

Products for DNAH3 Gene

Sources for DNAH3 Gene

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