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Aliases for DNAH3 Gene

Aliases for DNAH3 Gene

  • Dynein, Axonemal, Heavy Chain 3 2 3
  • DNAHC3B 3 4 6
  • Dynein, Axonemal, Heavy Polypeptide 3 2 3
  • Axonemal Beta Dynein Heavy Chain 3 3 4
  • Ciliary Dynein Heavy Chain 3 3 4
  • Dnahc3-B 3 4
  • Hsadhc3 3 4
  • Dynein Heavy Chain 3, Axonemal 3
  • Epididymis Luminal Protein 36 3
  • Axonemal Dynein, Heavy Chain 3
  • HEL-36 3
  • DLP3 3

External Ids for DNAH3 Gene

Previous GeneCards Identifiers for DNAH3 Gene

  • GC16U990018
  • GC16M020871
  • GC16M020911
  • GC16M020910
  • GC16M020851
  • GC16M019480

Summaries for DNAH3 Gene

GeneCards Summary for DNAH3 Gene

DNAH3 (Dynein, Axonemal, Heavy Chain 3) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DNAH1.

UniProtKB/Swiss-Prot for DNAH3 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAH3 Gene

Genomics for DNAH3 Gene

Regulatory Elements for DNAH3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAH3 Gene

Start:
20,933,111 bp from pter
End:
21,159,441 bp from pter
Size:
226,331 bases
Orientation:
Minus strand

Genomic View for DNAH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAH3 Gene

Proteins for DNAH3 Gene

  • Protein details for DNAH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD57-DYH3_HUMAN
    Recommended name:
    Dynein heavy chain 3, axonemal
    Protein Accession:
    Q8TD57
    Secondary Accessions:
    • O00437
    • O15437
    • O43326
    • Q3C0H2
    • Q8WUP9
    • Q9UEM3
    • Q9UEM5
    • Q9UG35

    Protein attributes for DNAH3 Gene

    Size:
    4116 amino acids
    Molecular mass:
    470771 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains

    Alternative splice isoforms for DNAH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAH3 Gene

Proteomics data for DNAH3 Gene at MOPED

Post-translational modifications for DNAH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAH3 Gene

Domains for DNAH3 Gene

Gene Families for DNAH3 Gene

HGNC:
  • DN :Axonemal dyneins

Suggested Antigen Peptide Sequences for DNAH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD57

UniProtKB/Swiss-Prot:

DYH3_HUMAN :
  • Q8TD57
Domain:
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).
Family:
  • Belongs to the dynein heavy chain family.
genes like me logo Genes that share domains with DNAH3: view

Function for DNAH3 Gene

Molecular function for DNAH3 Gene

UniProtKB/Swiss-Prot Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

Gene Ontology (GO) - Molecular Function for DNAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 9256245
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity --
genes like me logo Genes that share ontologies with DNAH3: view

Animal Model Products

CRISPR Products

miRNA for DNAH3 Gene

miRTarBase miRNAs that target DNAH3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAH3 Gene

Localization for DNAH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAH3 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAH3 Gene COMPARTMENTS Subcellular localization image for DNAH3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005858 axonemal dynein complex NAS 9256245
GO:0005874 microtubule IEA --
GO:0030286 dynein complex --
genes like me logo Genes that share ontologies with DNAH3: view

Pathways for DNAH3 Gene

genes like me logo Genes that share pathways with DNAH3: view

Pathways by source for DNAH3 Gene

1 KEGG pathway for DNAH3 Gene

Interacting Proteins for DNAH3 Gene

Gene Ontology (GO) - Biological Process for DNAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001539 cilium or flagellum-dependent cell motility NAS 9256245
GO:0007018 microtubule-based movement IEA --
GO:0008152 metabolic process NAS 9256245
genes like me logo Genes that share ontologies with DNAH3: view

Transcripts for DNAH3 Gene

Unigene Clusters for DNAH3 Gene

Dynein, axonemal, heavy chain 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAH3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNAH3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAH3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -
SP2:
SP3: -
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b ^ 47 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5: -

ExUns: 48 ^ 49 ^ 50a · 50b · 50c ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64a · 64b
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for DNAH3 Gene

GeneLoc Exon Structure for
DNAH3
ECgene alternative splicing isoforms for
DNAH3

Expression for DNAH3 Gene

mRNA expression in normal human tissues for DNAH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAH3 Gene

This gene is overexpressed in Testis (19.3), Fallopian Tube (7.9), Cervix - Endocervix (4.8), and Lung (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAH3 Gene

SOURCE GeneReport for Unigene cluster for DNAH3 Gene Hs.526500

mRNA Expression by UniProt/SwissProt for DNAH3 Gene

Q8TD57-DYH3_HUMAN
Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
genes like me logo Genes that share expressions with DNAH3: view

In Situ Assay Products

Orthologs for DNAH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAH3 35
  • 99.35 (n)
  • 99.37 (a)
DNAH3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAH3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAH3 35
  • 88.6 (n)
  • 89.75 (a)
DNAH3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnah3 35
  • 84.3 (n)
  • 87.31 (a)
Dnah3 36
  • 87 (a)
OneToOne
Dnahc3 16
oppossum
(Monodelphis domestica)
Mammalia DNAH3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAH3 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnah3 35
  • 84.33 (n)
  • 86.99 (a)
chicken
(Gallus gallus)
Aves DNAH3 35
  • 70.74 (n)
  • 74.13 (a)
DNAH3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnah3 35
  • 70.43 (n)
  • 75.63 (a)
zebrafish
(Danio rerio)
Actinopterygii DNAH3 36
  • 70 (a)
OneToOne
si:dkey-161j23.4 35
  • 67.65 (n)
  • 70.5 (a)
wufj36g10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002009 35
  • 55.69 (n)
  • 51.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17150 35
  • 55.61 (n)
  • 51.11 (a)
CG17150 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for DNAH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAH3 Gene

ENSEMBL:
Gene Tree for DNAH3 (if available)
TreeFam:
Gene Tree for DNAH3 (if available)

Paralogs for DNAH3 Gene

Selected SIMAP similar genes for DNAH3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DNAH3 Gene

genes like me logo Genes that share paralogs with DNAH3: view

Variants for DNAH3 Gene

Sequence variations from dbSNP and Humsavar for DNAH3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs111171 -- 20,948,068(+) acagc(A/G)tccaa intron-variant
rs170674 -- 21,021,509(+) ACTTT(C/G)CCTAC intron-variant
rs172958 -- 21,022,366(+) GGAAA(C/T)ACTCT intron-variant
rs179326 -- 21,021,464(+) GAATA(C/T)CACCC intron-variant
rs182782 -- 21,085,740(+) CACTG(G/T)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAH3 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv457444 CNV Loss 19166990
nsv833166 CNV Gain+Loss 17160897
nsv819009 CNV Loss 19587683
nsv435666 CNV Deletion 17901297

Relevant External Links for DNAH3 Gene

HapMap Linkage Disequilibrium report
DNAH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAH3 Gene

Disorders for DNAH3 Gene

Relevant External Links for DNAH3

Genetic Association Database (GAD)
DNAH3
Human Genome Epidemiology (HuGE) Navigator
DNAH3
genes like me logo Genes that share disorders with DNAH3: view

No data available for UniProtKB/Swiss-Prot for DNAH3 Gene

Publications for DNAH3 Gene

  1. Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. (PMID: 9256245) Chapelin C. … Amselem S. (FEBS Lett. 1997) 2 3 4
  2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PMID: 9373155) Neesen J. … Schmid M. (Gene 1997) 2 3 4
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DNAH3 Gene

Sources for DNAH3 Gene

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