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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAH2 Gene

protein-coding   GIFtS: 48
GCID: GC17P007623

dynein, axonemal, heavy chain 2

(Previous names: dynein, axonemal, heavy polypeptide 2, dynein heavy chain...)
(Previous symbol: DNHD3)
 Explore 2 diseases affiliated with
DNAH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DNAH2    

Aliases
for DNAH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dynein, Axonemal, Heavy Chain 21 2     Axonemal Beta Dynein Heavy Chain 22 3
DNHD31 2 3     Ciliary Dynein Heavy Chain 22 3
DNAHC22 3 5     Dynein Heavy Chain Domain-Containing Protein 32 3
Dynein Heavy Chain Domain 31 2     FLJ466751
Dynein, Axonemal, Heavy Polypeptide 21 2     Dynein Heavy Chain 2, Axonemal2
KIAA15031 3     Dynein, Axonemal, Heavy Chain-22

External Ids:    HGNC: 29481   Entrez Gene: 1467542   Ensembl: ENSG000001839147   OMIM: 6033335   UniProtKB: Q9P2253   

Export aliases for DNAH2 gene to outside databases

Previous GC identifers: GC17M008184 GC17M008551 GC17P007624 GC02P084826 GC17P007864 GC17P007604 GC17U900597 GC17P007565 GC17P007518


Summaries
for DNAH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNAH2:
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains.
The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the
peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 (PubMed
9256245)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: DYH2_HUMAN, Q9P225
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein
has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm
motility; implicated in sperm flagellar assembly (By similarity)




Genomic Views
for DNAH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAH2 gene promoter:
         E2F-3a   E2F-4   E2F-5   C/EBPbeta   Sp1   E2F-2   E2F   E2F-1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNAH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

DNAH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007623:  view genomic region     (about GC identifiers)

Start:
 7,620,672 bp from pter      End:
 7,737,062 bp from pter
Size:
 116,391 bases      Orientation:
 plus strand

Proteins
for DNAH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DYH2_HUMAN, Q9P225 (See protein sequence)
Recommended Name: Dynein heavy chain 2, axonemal  
Size: 4427 amino acids; 507698 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme (Potential)
Rna editing: Modified_positions=Not_applicable; Note=Exon 13 included in isoform 3 is extensively edited in brain
Sequence caution: Sequence=AK128517; Type=Frameshift; Positions=3963; Sequence=BAA96027.2; Type=Erroneous initiation;
Secondary accessions: A8K992 B5MDX5 O15434 Q6PIH3 Q6ZR42
Alternative splicing: 3 isoforms:  Q9P225-1   Q9P225-2   Q9P225-3   (Variant in position: 812:E->G (in RNA edited version). Variant in position: 814:E->G (in RNA edited version). Variant in position: 826:T->A (in RNA edited version). Variant in position: 833:N->D (in RNA edited version). Variant in position: 838:K->E (in RNA edited version). Variant in position: 839:N->D (in RNA edited version). Variant in position: 841:K->E (in RNA edited version). Variant in position: 843:S->G (in RNA edited version). Variant in position: 855:T->A (in RNA edited version). Variant in position: 865:E->G (in RNA edited version). Variant in position: 869:Q->R (in RNA edited version). Variant in position: 872:Q->R (in RNA edited version))

Explore the universe of human proteins at neXtProt for DNAH2: NX_Q9P225

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P225

    • DNAH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065928.2  
    ENSEMBL proteins: 
     ENSP00000458355   ENSP00000460245   ENSP00000461273   ENSP00000461726   ENSP00000373825  
     ENSP00000082259  

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    Uscn Proteins for DNAH2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005858axonemal dynein complex NAS9256245
    GO:0005874microtubule IEA--
    GO:0030286dynein complex ----
    GO:0035085cilium axoneme IEA--


    DNAH2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DNAH2

    Protein Domains /
    Families
    for DNAH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNAH2 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR004273 Dynein_heavy_dom
     IPR011704 ATPase_dyneun-rel_AAA
     IPR026976 DNAH2
     IPR013602 Dynein_heavy_dom-2
     IPR013594 Dynein_heavy_dom-1

    Graphical View of Domain Structure for InterPro Entry Q9P225

    ProtoNet protein and cluster: Q9P225

    3 Blocks protein families:
    IPB004273 Dynein heavy chain
    IPB011704 ATPase associated with various cellular activities
    IPB013594 Dynein heavy chain


    UniProtKB/Swiss-Prot: DYH2_HUMAN, Q9P225
    Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein
    components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form
    a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and
    terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether
    the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase
    sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a
    regulatory function (By similarity)
    Similarity: Belongs to the dynein heavy chain family
    Similarity: Contains 5 TPR repeats


    Function
    for DNAH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DYH2_HUMAN, Q9P225
    Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein
    has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm
    motility; implicated in sperm flagellar assembly (By similarity)

         Genatlas biochemistry entry for DNAH2:
    dynein,axonemal,motor protein interacting with microtubules,heavy chain 2,inner arm,primarily expressed in trachea and
    testis,involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle
    apparatus,with ATPase activity

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: DNAH2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DNAH2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for DNAH2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity NAS9256245
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IEA--


    DNAH2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for DNAH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Huntington's disease0.40
    2Cytoskeleton remodeling Neurofilaments
    		Cytoplasmic microtubules0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for DNAH2
        Cytoplasmic microtubules



    1         Kegg Pathway  (Kegg details for DNAH2):
        Huntington's disease


    DNAH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for DNAH2 (Q9P2253 ENSP000003738254) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    DNAH1ENSP000004015144STRING: ENSP00000401514
    DNAH3ENSP000002613834STRING: ENSP00000261383
    DNAH7ENSP000003112734STRING: ENSP00000311273
    DNAH8ENSP000003523124STRING: ENSP00000352312
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001539ciliary or flagellar motility NAS9256245
    GO:0007018microtubule-based movement IEA--


    DNAH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNAH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAH2
    Search CenterWatch for drugs/clinical trials and news about DNAH2 / DYH2 

    Transcripts
    for DNAH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNAH2 gene: 
    NM_020877.2  

    Unigene Cluster for DNAH2:

    Dynein, axonemal, heavy chain 2
    Hs.367649  [show with all ESTs]
    Unigene Representative Sequence: AB040936
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572933 ENST00000570791(uc002git.3 uc010vuk.2) ENST00000575498
    ENST00000574518 ENST00000575105 ENST00000389173(uc002giu.1 uc010cnm.1)
    ENST00000082259

    miRNA
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    hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: DNAH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAH2 (see all 4)
    OriGene shRNA RFP: DNAH2
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DNAH2 (NM_020877)
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    Primer
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    Additional cDNA sequence: 

    AB040936.2 AK128517.1 AK292607.1 BC034225.1 BX648163.1 

    7 DOTS entries:

    DT.92010264  DT.100661399  DT.91754032  DT.97836263  DT.101977510  DT.87014376  DT.99998881 

    1 AceView cDNA sequence:

    BX648163 

    GeneLoc Exon Structure


    Expression
    for DNAH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DNAH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Neural TubeMesencephalic Floor PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Floor PlateSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)
    Mature follicles (In-vitro growth and ...)

    See DNAH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAH2

    SOURCE GeneReport for Unigene cluster: Hs.367649

    UniProtKB/Swiss-Prot: DYH2_HUMAN, Q9P225
    Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed
    in lung

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    In Situ
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    Orthologs
    for DNAH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DNAH2 gene from 3/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DNAH26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343655.1(9063-117946)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5560231 dynein heavy chain 2, axonemal-like 68.23(n)
    70.35(a)    		   556023  XM_001919712.3  XP_001919747.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kl-21 male fertility factor kl2 30.23(n)
    12.19(a)    		   3355181  NM_001015505.3  NP_001015505.3 


    ENSEMBL Gene Tree for DNAH2 (if available)
    TreeFam Gene Tree for DNAH2 (if available) 

    Paralogs
    for DNAH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAH2 gene
    DNAH52  DNAH82  DYNC1H12  DYNC2H12  DNAH92  DNAH32  DNAH112  DNAH72  
    DNAH62  DNAH12  DNAH102  DNAH172  
    17 SIMAP similar genes for DNAH2 using alignment to 4 protein entries:     DYH2_HUMAN (see all proteins):
    Dnahc11    Dnahc9    Dnahc3    Dnchc1    DNAH14    DNAH5
    DNAH1    DNAH12    DNAH7    DNAH6    DNAH3    DNAH11
    DNAH10    DYNC2H1    DNAH17    DNAH9    DNAH8

    DNAH2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DNAH2
    PGOHUM00000242883


    Genomic Variants
    for DNAH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2306 NCBI SNPs in DNAH2 are shown (see all 2306)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1467383051,2
    		--7621304(+) AGGGG-/CAGTTG
    TGACAGCT    GGGGG     		1 -- us2k10--------
    rs38038021,2
    		C,F,A,H,--7621464(+) TAGTAA/CTAGAG 1 -- us2k1 ese327Minor allele frequency- N:0.00EA NA NS WA CSA 2529
    rs73595241,2
    		C,F,H,--7621528(+) GTGGTG/AAACCC 1 -- us2k1 ese36Minor allele frequency- A:0.09EA NS NA WA 510
    rs580490671,2
    		C,F,--7621561(+) CTAGTT/CTGAGG 1 -- us2k17Minor allele frequency- C:0.24WA NA EA 366
    rs1837400671,2
    		--7621606(+) GATGGA/GGGAAG 1 -- us2k10--------
    rs15447241,2
    		C,F,A,H,--7621777(+) CAGCCG/TAATGA 1 -- us2k1 ese328Minor allele frequency- T:0.48NS EA NA MN WA 3658
    rs72098221,2
    		C,H--7621817(+) CGCCTG/AGGATT 1 -- us2k19Minor allele frequency- A:0.00NS EA MN 792
    rs352231711,2
    		F--7621834(+) ACCTGT/ACCGAG 1 -- us2k15Minor allele frequency- A:0.01MN 408
    rs15447251,2
    		C,F,H,--7621877(+) AGAGGC/AACCAC 1 -- us2k1 ese331Minor allele frequency- A:0.21NA EA MN NS WA 4718
    rs344987751,2
    		C,F,--7621922(+) CATGAC/TACAAT 1 -- us2k16Minor allele frequency- T:0.02MN EA 528

    HapMap Linkage Disequilibrium report for DNAH2 (7620672 - 7737062 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNAH2: --

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    Disorders / Diseases
    for DNAH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNAH2 for disorders           About GeneDecksing

    OMIM gene information: 603333    OMIM disorders: --

    2 diseases for DNAH2:    About MalaCards
    huntington's disease    retinitis


    Export disorders for DNAH2 gene to outside databases

    Publications
    for DNAH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAH2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DNAH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. (PubMed id 9256245)1, 2, 3 Chapelin C....Amselem S. (1997)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    3. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
    4. Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome. (PubMed id 20835228)2 Sakurai M.... Suzuki T. (2010)
    5. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    6. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1 Barrett J.C....Rich S.S. (2009)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)1 Wistow G.... Peterson K. (2002)

    External Searches for DNAH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DNAH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146754 HGNC: 2948 AceView: FLJ46675.2 Ensembl:ENSG00000183914 euGenes: HUgn146754
    ECgene: DNAH2 Kegg: 146754 H-InvDB: DNAH2

    Other Databases showing DNAH2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1503

    Specialized Databases showing DNAH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAH2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DNAH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNAH2 gene:
    Search GeneIP for patents involving DNAH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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