Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAH2 Gene

Aliases for DNAH2 Gene

  • Dynein, Axonemal, Heavy Chain 2 2 3
  • DNAHC2 3 4 6
  • Dynein Heavy Chain Domain-Containing Protein 3 3 4
  • Dynein, Axonemal, Heavy Polypeptide 2 2 3
  • Axonemal Beta Dynein Heavy Chain 2 3 4
  • Ciliary Dynein Heavy Chain 2 3 4
  • DNHD3 3 4
  • Dynein Heavy Chain 2, Axonemal 3
  • Dynein Heavy Chain Domain 3 2
  • KIAA1503 4

External Ids for DNAH2 Gene

Previous Symbols for DNAH2 Gene

  • DNHD3

Summaries for DNAH2 Gene

Entrez Gene Summary for DNAH2 Gene

  • Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAH2 Gene

DNAH2 (Dynein, Axonemal, Heavy Chain 2) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.

UniProtKB/Swiss-Prot for DNAH2 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAH2 Gene

Genomics for DNAH2 Gene

Genomic Location for DNAH2 Gene

Start:
7,717,313 bp from pter
End:
7,833,744 bp from pter
Size:
116,432 bases
Orientation:
Plus strand

Genomic View for DNAH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAH2 Gene

Regulatory Elements for DNAH2 Gene

Proteins for DNAH2 Gene

  • Protein details for DNAH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P225-DYH2_HUMAN
    Recommended name:
    Dynein heavy chain 2, axonemal
    Protein Accession:
    Q9P225
    Secondary Accessions:
    • A8K992
    • B5MDX5
    • O15434
    • Q6PIH3
    • Q6ZR42

    Protein attributes for DNAH2 Gene

    Size:
    4427 amino acids
    Molecular mass:
    507698 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains
    SequenceCaution:
    • Sequence=AK128517; Type=Frameshift; Positions=3963; Evidence={ECO:0000305}; Sequence=BAA96027.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAH2 Gene

Proteomics data for DNAH2 Gene at MOPED

Post-translational modifications for DNAH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAH2 Gene

No data available for DME Specific Peptides for DNAH2 Gene

Domains for DNAH2 Gene

Gene Families for DNAH2 Gene

HGNC:
  • DN :Axonemal dyneins

UniProtKB/Swiss-Prot:

DYH2_HUMAN
Domain:
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).:
    • Q9P225
Family:
  • Belongs to the dynein heavy chain family.:
    • Q9P225
Similarity:
  • Contains 5 TPR repeats.:
    • Q9P225
genes like me logo Genes that share domains with DNAH2: view

Function for DNAH2 Gene

Molecular function for DNAH2 Gene

GENATLAS Biochemistry: dynein,axonemal,motor protein interacting with microtubules,heavy chain 2,inner arm,primarily expressed in trachea and testis,involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle apparatus,with ATPase activity
UniProtKB/Swiss-Prot Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

Gene Ontology (GO) - Molecular Function for DNAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 9256245
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with DNAH2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAH2 Gene

Localization for DNAH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAH2 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAH2 Gene COMPARTMENTS Subcellular localization image for DNAH2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005858 axonemal dynein complex NAS 9256245
GO:0005874 microtubule IEA --
GO:0030286 dynein complex --
genes like me logo Genes that share ontologies with DNAH2: view

Pathways for DNAH2 Gene

genes like me logo Genes that share pathways with DNAH2: view

Pathways by source for DNAH2 Gene

1 KEGG pathway for DNAH2 Gene

Interacting Proteins for DNAH2 Gene

Gene Ontology (GO) - Biological Process for DNAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001539 cilium or flagellum-dependent cell motility NAS 9256245
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IEA --
GO:0008152 metabolic process NAS 9256245
genes like me logo Genes that share ontologies with DNAH2: view

Transcripts for DNAH2 Gene

mRNA/cDNA for DNAH2 Gene

(10) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAH2 Gene

Dynein, axonemal, heavy chain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAH2 Gene

No ASD Table

Relevant External Links for DNAH2 Gene

GeneLoc Exon Structure for
DNAH2
ECgene alternative splicing isoforms for
DNAH2

Expression for DNAH2 Gene

mRNA expression in normal human tissues for DNAH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAH2 Gene

This gene is overexpressed in Testis (7.7), Brain - Nucleus accumbens (basal ganglia) (4.8), and Brain - Caudate (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAH2 Gene

SOURCE GeneReport for Unigene cluster for DNAH2 Gene Hs.367649

mRNA Expression by UniProt/SwissProt for DNAH2 Gene

Q9P225-DYH2_HUMAN
Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
genes like me logo Genes that share expressions with DNAH2: view

Orthologs for DNAH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAH2 36
  • 99.43 (n)
  • 99.16 (a)
DNAH2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAH2 36
  • 89.05 (n)
  • 92.45 (a)
DNAH2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAH2 36
  • 87.71 (n)
  • 91.18 (a)
DNAH2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnah2 36
  • 86.43 (n)
  • 91.18 (a)
Dnah2 37
  • 90 (a)
OneToOne
Dnahc2 16
oppossum
(Monodelphis domestica)
Mammalia DNAH2 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 35 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Dnah2 36
  • 86.86 (n)
  • 91.88 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DNAH2 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnah2 36
  • 70.71 (n)
  • 73.52 (a)
zebrafish
(Danio rerio)
Actinopterygii AL935046.1 37
  • 68 (a)
OneToOne
LOC556023 36
  • 67.84 (n)
  • 69.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta kl-2 36
  • 30.26 (n)
  • 12.2 (a)
kl-2 37
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13463 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToOne
Species with no ortholog for DNAH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAH2 Gene

ENSEMBL:
Gene Tree for DNAH2 (if available)
TreeFam:
Gene Tree for DNAH2 (if available)

Paralogs for DNAH2 Gene

Selected SIMAP similar genes for DNAH2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DNAH2 Gene

genes like me logo Genes that share paralogs with DNAH2: view

Variants for DNAH2 Gene

Sequence variations from dbSNP and Humsavar for DNAH2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs184265 -- 7,749,469(+) TCCAA(A/G)ACATC intron-variant
rs186283 -- 7,750,347(+) gtcca(A/G)ctggt intron-variant
rs191058 -- 7,749,511(+) TACTA(A/G)AAATG intron-variant
rs191752 -- 7,749,442(+) GCTCA(A/G)ATGTT intron-variant
rs192805 -- 7,749,555(+) catat(A/C)attat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAH2 Gene

Variant ID Type Subtype PubMed ID
esv2520895 CNV Deletion 19546169
nsv833351 CNV Loss 17160897
esv2715602 CNV Deletion 23290073
nsv518326 CNV Gain 19592680
esv2715603 CNV Deletion 23290073
nsv907653 CNV Loss 21882294
esv2662285 CNV Deletion 23128226

Relevant External Links for DNAH2 Gene

HapMap Linkage Disequilibrium report
DNAH2

Disorders for DNAH2 Gene

Relevant External Links for DNAH2

Genetic Association Database (GAD)
DNAH2
genes like me logo Genes that share disorders with DNAH2: view

No data available for UniProtKB/Swiss-Prot for DNAH2 Gene

Publications for DNAH2 Gene

  1. Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. (PMID: 9256245) Chapelin C. … Amselem S. (FEBS Lett. 1997) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PMID: 19430480) Barrett J.C. … Rich S.S. (Nat. Genet. 2009) 3 49
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PMID: 21182205) Tarallo R. … Weisz A. (Proteomics 2011) 3

Products for DNAH2 Gene

Sources for DNAH2 Gene

Back to Top

Content