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Aliases for DNAH17 Gene

Aliases for DNAH17 Gene

  • Dynein, Axonemal, Heavy Chain 17 2 3
  • DNEL2 3 4 6
  • Axonemal Dynein Heavy Chain-Like Protein 1 3 4
  • Ciliary Dynein Heavy Chain-Like Protein 1 3 4
  • Dynein, Axonemal, Heavy Polypeptide 17 2 3
  • Dynein, Axonemal, Heavy Chain Like 1 2 3
  • Axonemal Beta Dynein Heavy Chain 17 3 4
  • Dynein, Axonemal, Heavy Like 1 2 3
  • Dynein Light Chain 2, Axonemal 3 4
  • Ciliary Dynein Heavy Chain 17 3 4
  • DNAHL1 3 4
  • Dynein Heavy Chain 17, Axonemal 3
  • Axonemal Dynein Heavy Chain 3

External Ids for DNAH17 Gene

Previous HGNC Symbols for DNAH17 Gene

  • DNAHL1

Previous GeneCards Identifiers for DNAH17 Gene

  • GC17P076291
  • GC17M079807
  • GC17M076880
  • GC17M077016
  • GC17M077017
  • GC17M073931
  • GC17U900585
  • GC17M076416
  • GC17M071842

Summaries for DNAH17 Gene

Entrez Gene Summary for DNAH17 Gene

  • Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAH17 Gene

DNAH17 (Dynein, Axonemal, Heavy Chain 17) is a Protein Coding gene. Diseases associated with DNAH17 include brachial plexus neuropathy. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.

UniProtKB/Swiss-Prot for DNAH17 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAH17 Gene

Genomics for DNAH17 Gene

Regulatory Elements for DNAH17 Gene

Genomic Location for DNAH17 Gene

Start:
78,423,697 bp from pter
End:
78,577,394 bp from pter
Size:
153,698 bases
Orientation:
Minus strand

Genomic View for DNAH17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAH17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAH17 Gene

Proteins for DNAH17 Gene

  • Protein details for DNAH17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFH2-DYH17_HUMAN
    Recommended name:
    Dynein heavy chain 17, axonemal
    Protein Accession:
    Q9UFH2
    Secondary Accessions:
    • O00431
    • O15206
    • Q2M2Y1
    • Q6ZRQ2
    • Q8N7Q7

    Protein attributes for DNAH17 Gene

    Size:
    4485 amino acids
    Molecular mass:
    511787 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains
    SequenceCaution:
    • Sequence=CAA04165.1; Type=Frameshift; Positions=3502, 3533; Evidence={ECO:0000305}; Sequence=CAB59252.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAH17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAH17 Gene

Proteomics data for DNAH17 Gene at MOPED

Post-translational modifications for DNAH17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAH17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAH17 Gene

Domains for DNAH17 Gene

Gene Families for DNAH17 Gene

HGNC:
  • DN :Axonemal dyneins

Suggested Antigen Peptide Sequences for DNAH17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFH2

UniProtKB/Swiss-Prot:

DYH17_HUMAN :
  • Q9UFH2
Domain:
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).
Family:
  • Belongs to the dynein heavy chain family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with DNAH17: view

Function for DNAH17 Gene

Molecular function for DNAH17 Gene

GENATLAS Biochemistry: dynein,axonemal,motor protein interacting with microtubules,heavy chain 17 (91kDa),outer arm,specifically expressed in testis,involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle apparatus,with ATPase activity
UniProtKB/Swiss-Prot Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

Gene Ontology (GO) - Molecular Function for DNAH17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 9373155
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with DNAH17: view

Phenotypes for DNAH17 Gene

GenomeRNAi human phenotypes for DNAH17:
genes like me logo Genes that share phenotypes with DNAH17: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAH17 Gene

Localization for DNAH17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAH17 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAH17 Gene COMPARTMENTS Subcellular localization image for DNAH17 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAH17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005858 axonemal dynein complex NAS 9373155
GO:0005874 microtubule IEA --
GO:0030286 dynein complex --
genes like me logo Genes that share ontologies with DNAH17: view

Pathways for DNAH17 Gene

SuperPathways for DNAH17 Gene

No Data Available

Interacting Proteins for DNAH17 Gene

Gene Ontology (GO) - Biological Process for DNAH17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001539 cilium or flagellum-dependent cell motility NAS 9373155
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IEA --
GO:0007165 signal transduction --
GO:0008152 metabolic process NAS 9373155
genes like me logo Genes that share ontologies with DNAH17: view

No data available for Pathways by source for DNAH17 Gene

Transcripts for DNAH17 Gene

mRNA/cDNA for DNAH17 Gene

(8) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAH17 Gene

Dynein, axonemal, heavy chain 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAH17

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNAH17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAH17 Gene

No ASD Table

Relevant External Links for DNAH17 Gene

GeneLoc Exon Structure for
DNAH17
ECgene alternative splicing isoforms for
DNAH17

Expression for DNAH17 Gene

mRNA expression in normal human tissues for DNAH17 Gene

mRNA differential expression in normal tissues according to GTEx for DNAH17 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (13.6), Testis (10.6), Whole Blood (5.2), and Brain - Substantia nigra (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAH17 Gene

SOURCE GeneReport for Unigene cluster for DNAH17 Gene Hs.375975

mRNA Expression by UniProt/SwissProt for DNAH17 Gene

Q9UFH2-DYH17_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with DNAH17: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DNAH17 Gene

Orthologs for DNAH17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAH17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAH17 35
  • 88.13 (n)
  • 92.18 (a)
DNAH17 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAH17 35
  • 87.85 (n)
  • 91.44 (a)
DNAH17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnah17 35
  • 86.15 (n)
  • 91.38 (a)
Dnah17 36
  • 91 (a)
OneToOne
Dnahc17 16
oppossum
(Monodelphis domestica)
Mammalia DNAH17 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAH17 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnah17 35
  • 85.81 (n)
  • 91.23 (a)
chicken
(Gallus gallus)
Aves DNAH17 35
  • 75.68 (n)
  • 76.9 (a)
DNAH17 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAH17 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dnah9l 36
  • 57 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for DNAH17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAH17 Gene

ENSEMBL:
Gene Tree for DNAH17 (if available)
TreeFam:
Gene Tree for DNAH17 (if available)

Paralogs for DNAH17 Gene

Selected SIMAP similar genes for DNAH17 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DNAH17: view

Variants for DNAH17 Gene

Sequence variations from dbSNP and Humsavar for DNAH17 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs584102 -- 78,449,540(-) ACCCC(C/T)GCCAA synonymous-codon, reference
rs584202 -- 78,437,053(+) AGGCA(A/C)CCAGC intron-variant
rs587370 -- 78,431,205(+) CAAAA(C/T)GTTAA intron-variant
rs588463 -- 78,465,128(+) ggttt(C/T)gctgt intron-variant
rs589355 -- 78,465,291(+) ccacc(G/T)cccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAH17 Gene

Variant ID Type Subtype PubMed ID
nsv908881 CNV Loss 21882294
nsv833555 CNV Loss 17160897
dgv3280n71 CNV Loss 21882294
nsv908887 CNV Loss 21882294
esv2716309 CNV Deletion 23290073
esv2716310 CNV Deletion 23290073
esv2512413 CNV Insertion 19546169
esv2185799 CNV Deletion 18987734
esv2716311 CNV Deletion 23290073
esv2716312 CNV Deletion 23290073
esv2716313 CNV Deletion 23290073
esv2658314 CNV Deletion 23128226
nsv470609 CNV Loss 18288195
nsv524975 CNV Loss 19592680
esv995150 CNV Deletion 20482838
esv2650648 CNV Deletion 19546169
nsv512507 CNV Loss 21212237
esv2301284 CNV Deletion 18987734
esv2716314 CNV Deletion 23290073
esv2674887 CNV Deletion 23128226
dgv469e201 CNV Deletion 23290073
nsv527452 CNV Gain 19592680
nsv521975 CNV Gain 19592680
dgv3281n71 CNV Gain 21882294
nsv908890 CNV Gain 21882294
esv997097 CNV Deletion 20482838
esv2716315 CNV Deletion 23290073
nsv112223 CNV Insertion 16902084
nsv457916 CNV Gain 19166990
nsv520357 CNV Loss 19592680
nsv908891 CNV Loss 21882294
esv2716316 CNV Deletion 23290073

Relevant External Links for DNAH17 Gene

HapMap Linkage Disequilibrium report
DNAH17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAH17 Gene

Disorders for DNAH17 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DNAH17 Gene including...

Search for DNAH17 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DNAH17 Gene

Relevant External Links for DNAH17

Genetic Association Database (GAD)
DNAH17
Human Genome Epidemiology (HuGE) Navigator
DNAH17
genes like me logo Genes that share disorders with DNAH17: view

No data available for UniProtKB/Swiss-Prot for DNAH17 Gene

Publications for DNAH17 Gene

  1. A potential human axonemal dynein heavy-chain gene maps to 17q25. (PMID: 9545504) Milisav I. … Affara N.A. (Mamm. Genome 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PMID: 9373155) Neesen J. … Schmid M. (Gene 1997) 3 4
  5. Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. (PMID: 24886709) Ko A. … Pajukanta P. (Nat Commun 2014) 3

Products for DNAH17 Gene

Sources for DNAH17 Gene

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