Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DNAH14 Gene

protein-coding   GIFtS: 46
GCID: GC01P225083

Dynein, Axonemal, Heavy Chain 14

(Previous names: dynein, axonemal, heavy polypeptide 14, chromosome 1 open...)
(Previous symbol: C1orf67)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dynein, Axonemal, Heavy Chain 141 2     HL182 5
C1orf671 2 3     Chromosome 1 Open Reading Frame 671
Dynein, Axonemal, Heavy Polypeptide 141 2     Dnahc142
Axonemal Beta Dynein Heavy Chain 142 3     HL-182
Ciliary Dynein Heavy Chain 142 3     Dynein Heavy Chain 14, Axonemal2

External Ids:    HGNC: 29451   Entrez Gene: 1276022   Ensembl: ENSG000001858427   OMIM: 6033415   UniProtKB: Q0VDD83   

Export aliases for DNAH14 gene to outside databases

Previous GC identifers: GC01U990036 GC01P222303 GC01P222302 GC03M057407 GC01P221576 GC01P223398 GC01P223285 GC01P223184 GC01P195635


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DNAH14 Gene:
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate
chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal
dynein heavy chain (DHC) (Vaughan et al., 1996 (PubMed 8812413)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAH14 Gene:
DNAH14 (dynein, axonemal, heavy chain 14) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity.

UniProtKB/Swiss-Prot: DYH14_HUMAN, Q0VDD8
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in
sperm motility; implicated in sperm flagellar assembly (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAH14 gene promoter:
         RORalpha1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DNAH14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAH14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q42.13

DNAH14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAH14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P225083:  view genomic region     (about GC identifiers)

Start:
225,083,964 bp from pter      End:
225,586,996 bp from pter
Size:
503,033 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DYH14_HUMAN, Q0VDD8 (See protein sequence)
Recommended Name: Dynein heavy chain 14, axonemal  
Size: 3507 amino acids; 399895 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Sequence caution: Sequence=AAI19717.1; Type=Erroneous initiation; Sequence=AAI19718.1; Type=Erroneous initiation;
Sequence=CAI95150.2; Type=Erroneous gene model prediction; Sequence=CAI95641.1; Type=Erroneous gene model
prediction; Sequence=CAI95642.2; Type=Erroneous gene model prediction; Sequence=EAW69735.1; Type=Erroneous gene
model prediction;
Secondary accessions: A6NG62 A6NNL2 Q0VDD9 Q4VXC7 Q4VXG4 Q4VXG5 Q5VU33 Q5VU34
Alternative splicing: 4 isoforms:  Q0VDD8-1   Q0VDD8-2   Q0VDD8-3   Q0VDD8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAH14: NX_Q0VDD8

Explore proteomics data for DNAH14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys312
  • Glycosylation2 at Asn1818
  • Modification sites at PhosphoSitePlus

  • See DNAH14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138626.1  NP_001364.1  NP_659426.2  

    ENSEMBL proteins: 
     ENSP00000409472   ENSP00000412969   ENSP00000383737   ENSP00000355814   ENSP00000355813  
     ENSP00000392061   ENSP00000409971   ENSP00000332424   ENSP00000429568   ENSP00000429122  
     ENSP00000328980   ENSP00000398678   ENSP00000414699   ENSP00000414402   ENSP00000355815  

    DNAH14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DNAH14
    GenScript Custom Purified and Recombinant Proteins Services for DNAH14
    Novus Biologicals DNAH14 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAH14

     
    Search eBioscience for Proteins for DNAH14 

     
    antibodies-online proteins for DNAH14 

     
    Search antibodies-online for peptides for DNAH14

    DNAH14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DNAH14
    Novus Biologicals DNAH14 Antibodies
    Search for Antibodies for DNAH14 at Abcam
    Cloud-Clone Corp. Antibodies for DNAH14
    Search ThermoFisher Antibodies for DNAH14
    antibodies-online antibodies for DNAH14 (13 products) 

    DNAH14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNAH14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNAH14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNAH14
    Cloud-Clone Corp. CLIAs for DNAH14
    Search eBioscience for ELISAs for DNAH14 
    antibodies-online kits for DNAH14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DN: Axonemal dyneins

    5 InterPro protein domains:
     IPR004273 Dynein_heavy_dom
     IPR024317 Dynein_heavy_chain_D4_dom
     IPR024743 Dynein_HC_stalk
     IPR027417 P-loop_NTPase
     IPR026983 DHC_fam

    Graphical View of Domain Structure for InterPro Entry Q0VDD8

    ProtoNet protein and cluster: Q0VDD8

    UniProtKB/Swiss-Prot: DYH14_HUMAN, Q0VDD8
    Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other
    dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head,
    which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and
    AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not
    clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two
    non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes
    ATP, the others may serve a regulatory function (By similarity)
    Similarity: Belongs to the dynein heavy chain family


    Find genes that share domains with DNAH14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYH14_HUMAN, Q0VDD8
    Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
    Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in
    sperm motility; implicated in sperm flagellar assembly (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity ----
         
    Find genes that share ontologies with DNAH14           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DNAH14:
     Elongated cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DNAH14

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DNAH14 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DNAH14
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAH14
    Predesigned siRNA for gene silencing in human, mouse, rat DNAH14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAH14

    Clone
    Products:
         
    OriGene clones in human, mouse for DNAH14 (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DNAH14 (NM_001373)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAH14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAH14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DNAH14
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAH14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DYH14_HUMAN, Q0VDD8: Cytoplasm, cytoskeleton, cilium axoneme (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    endosome1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005929cilium IEA--
    GO:0030286dynein complex IEA--

    Find genes that share ontologies with DNAH14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DNAH14 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAH14
    Interactions:

        Search GeneGlobe Interaction Network for DNAH14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAH14 (ENSP000004144024) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN2ENSP000004089104STRING: ENSP00000408910
    DNAH1ENSP000004015144STRING: ENSP00000401514
    DNAH10ENSP000003867704STRING: ENSP00000386770
    DNAH12ENSP000002959374STRING: ENSP00000295937
    DNAH17ENSP000003744904STRING: ENSP00000374490
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement IEA--

    Find genes that share ontologies with DNAH14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAH14 (DYH14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DNAH14 gene (3 alternative transcripts): 
    NM_001145154.1  NM_001373.1  NM_144989.2  

    Unigene Cluster for DNAH14:

    Dynein, axonemal, heavy chain 14
    Hs.133977  [show with all ESTs]
    Unigene Representative Sequence: NM_001373
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000445597 ENST00000413949 ENST00000400952(uc001hou.4 uc001hot.4)
    ENST00000366849 ENST00000498360 ENST00000366848 ENST00000486657 ENST00000439375
    ENST00000433124 ENST00000453375 ENST00000474127 ENST00000328556 ENST00000474801
    ENST00000495456 ENST00000327794(uc001hox.2) ENST00000450490 ENST00000428003
    ENST00000430092(uc001how.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAH14 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DNAH14
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAH14
    Predesigned siRNA for gene silencing in human, mouse, rat DNAH14
    Clone
    Products:
         
    OriGene clones in human, mouse for DNAH14 (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DNAH14 (NM_001373)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAH14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAH14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAH14
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAH14
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DNAH14
      QuantiTect SYBR Green Assays in human, mouse, rat DNAH14
      QuantiFast Probe-based Assays in human, mouse, rat DNAH14

    Additional mRNA sequence: 

    BC017415.2 BC042869.1 BC119716.1 BC119717.1 CR936804.1 U61741.1 

    12 DOTS entries:

    DT.441681  DT.121397237  DT.121360822  DT.100748266  DT.40300276  DT.65287590  DT.121457981  DT.40237275 
    DT.121448792  DT.91885421  DT.95208396  DT.95241586 

    Selected AceView cDNA sequences (see all 28):

    AI015591 BG217954 BG211987 BG214278 BG221427 BG190449 BG216491 BG186731 
    BG219476 BG199089 BG210654 BG198565 BG213686 BG204743 BG206371 BG195015 
    BG199613 BG198162 BG191945 BG208980 BG220952 BG202710 T98994 BG202709 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DNAH14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTAATA
    DNAH14 Expression
    About this image

    DNAH14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAH14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133977
        Custom PCR Arrays for DNAH14
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAH14
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAH14
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DNAH14
    QuantiTect SYBR Green Assays in human, mouse, rat DNAH14
    QuantiFast Probe-based Assays in human, mouse, rat DNAH14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DNAH14 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnahc145
    Dnah141
    dynein, axonemal, heavy chain 141, 5 72.61(n)1
    63.55(a)1
      1 (84.83 cM)5
    2409601  XM_006497100.11  XP_006497163.11 
     1817389885 
    chicken
    (Gallus gallus)
    Aves DNAH146
    dynein, axonemal, heavy chain 14
    28(a)
    1 ↔ 1
    3(16773684-16784549)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnah141 dynein, axonemal, heavy chain 14 56.36(n)
    48.15(a)
      100036695  XM_002939758.2  XP_002939804.2 


    ENSEMBL Gene Tree for DNAH14 (if available)
    TreeFam Gene Tree for DNAH14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DNAH14 gene
    16 SIMAP similar genes for DNAH14 using alignment to 11 protein entries:     DYH14_HUMAN (see all proteins):
    DNAH6    Dnahc3    DNAH2    DNAH5    DNAH17    DNAH9
    Dnahc9    DYNC1H1    Dnchc1    DYNC2H1    Dnahc11    DNAH8
    DNAH10    DNAH11    DNAH12    DNAH1

    Find genes that share paralogs with DNAH14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DNAH14 (see all 9063)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580307301,2
    C--195693346(+) ACAGA-/GACAGA
            
    CCTGA
    2 -- int11Minor allele frequency- GACAGA:0.00NA 2
    rs341382111,2
    C--195756427(+) CTATC-/T/TATC
            
    AATCA
    1 -- int11NA 2
    rs711700621,2
    C--195890699(-) TTAAT-/TCTGTTT 1 -- int11Minor allele frequency- TC:0.00NA 2
    rs1489105321,2
    C--225115398(+) GTTTAC/TTGCAG 3 -- us2k10--------
    rs1929356221,2
    --225115419(+) AATAGC/TGAAGA 3 -- us2k10--------
    rs1449763501,2
    C--225115420(+) ATAGCA/GAAGAC 3 -- us2k10--------
    rs1480254951,2
    --225115425(+) GAAGAC/TATGGA 3 -- us2k10--------
    rs1405373881,2
    C--225115506(+) TGCAGA/CCATAA 3 -- us2k10--------
    rs1841273201,2
    --225115608(+) CTGCAA/CGTTCT 3 -- us2k10--------
    rs1878652691,2
    --225115621(+) CTCGTA/GAGTGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAH14 (225083964 - 225333964 bp, first 250kb of DNAH14)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DNAH14 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673679CNV Deletion23128226
    esv2723817CNV Deletion23290073
    esv2367547CNV Deletion18987734
    esv2723850CNV Deletion23290073
    esv4999CNV Deletion18987735
    esv2511976CNV Deletion19546169
    esv2607015CNV Deletion19546169
    esv2723839CNV Deletion23290073
    esv2552398CNV Deletion19546169
    esv2723861CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DNAH14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAH14
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAH14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603341    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DNAH14:
    Primary ciliary dyskinesia

    Find genes that share disorders with DNAH14           About GenesLikeMe


    Export disorders for DNAH14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DNAH14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DNAH14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple mouse chromosomal loci for dynein-based motility. (PubMed id 8812413)1, 3 Vaughan K.T....Vallee R.B. (Genomics 1996)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 127602 HGNC: 2945 AceView: LOC127602 Ensembl:ENSG00000185842 euGenes: HUgn127602
    ECgene: DNAH14 H-InvDB: DNAH14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DNAH14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DNAH14 gene:
    Search GeneIP for patents involving DNAH14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DNAH14  
     OriGene qPCR primer pairs and template standards for DNAH14   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DNAH14  
     OriGene qSTAR qPCR primer pairs in human, mouse for DNAH14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DNAH14   OriGene Custom Protein Services for DNAH14  

     
     
     Block miRNA regulation of human, mouse, rat DNAH14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DNAH14
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAH14 Predesigned siRNA for gene silencing in human, mouse, rat DNAH14
     QuantiFast Probe-based Assays in human, mouse, rat DNAH14 QuantiTect SYBR Green Assays in human, mouse, rat DNAH14
     Custom PCR Arrays for DNAH14 Search Chromatin IP Primers for DNAH14
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DNAH14  Search GeneGlobe Interaction Network for DNAH14
     Regulatory tfbs in DNAH14 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DNAH14 GenScript cDNA clones with any tag delivered in your preferred vector for DNAH14
     GenScript Custom Assay Services for DNAH14 GenScript Custom overexpressing Cell Line Services for DNAH14
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DNAH14 (DYH14)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DNAH14 antibodies
     DNAH14 proteins
     Search for Antibodies for DNAH14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DNAH14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DNAH14
     Antibodies for DNAH14
     ELISAs for DNAH14
     CLIAs for DNAH14



     Browse ESI BIO Cell Lines and PureStem Progenitors for DNAH14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH14
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DNAH14
     Browse SwitchGear Promoter luciferase reporter plasmids for DNAH14
     Search ThermoFisher Antibodies for DNAH14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAH14
     Browse compounds at ApexBio
     Search Addgene for plasmids for DNAH14
      Search eBioscience for proteins for DNAH14
      Search eBioscience for elisas for DNAH14
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DNAH14
     antibodies-online antibodies for DNAH14 (13 products)
     antibodies-online kits for DNAH14
      Search antibodies-online for peptides for DNAH14
     antibodies-online proteins for DNAH14
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DNAH14 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4