Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNAH14 Gene

protein-coding GIFtS: 46
GCID: GC01P225083

Dynein, Axonemal, Heavy Chain 14

(Previous names: dynein, axonemal, heavy polypeptide 14, chromosome 1 open...)
(Previous symbol: C1orf67)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Dynein, Axonemal, Heavy Chain 14¹ ²		HL18² ⁵
C1orf67¹ ² ³		Chromosome 1 Open Reading Frame 67¹
Dynein, Axonemal, Heavy Polypeptide 14¹ ²		Dnahc14²
Axonemal Beta Dynein Heavy Chain 14² ³		HL-18²
Ciliary Dynein Heavy Chain 14² ³		Dynein Heavy Chain 14, Axonemal²

External Ids:	HGNC: 2945¹	Entrez Gene: 127602²	Ensembl: ENSG00000185842⁷	OMIM: 603341⁵	UniProtKB: Q0VDD8³

Export aliases for DNAH14 gene to outside databases

Previous GC identifers: GC01U990036 GC01P222303 GC01P222302 GC03M057407 GC01P221576 GC01P223398 GC01P223285 GC01P223184 GC01P195635

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAH14 Gene:

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate

chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal

dynein heavy chain (DHC) (Vaughan et al., 1996 (PubMed 8812413)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DNAH14 Gene:

DNAH14 (dynein, axonemal, heavy chain 14) is a protein-coding gene. Diseases associated with DNAH14 include tyrosinemia, and primary ciliary dyskinesia, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include microtubule motor activity and ATP binding.

UniProtKB/Swiss-Prot: DYH14_HUMAN, Q0VDD8

Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.

Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in

sperm motility; implicated in sperm flagellar assembly (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.2 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNAH14 gene promoter:
RORalpha1 C/EBPalpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DNAH14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAH14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12 Ensembl cytogenetic band: 1q42.12 HGNC cytogenetic band: 1q42.13

DNAH14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAH14 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P225083: view genomic region (about GC identifiers)

Start:	225,083,964 bp from pter	End:	225,586,996 bp from pter
Size:	503,033 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DYH14_HUMAN, Q0VDD8 (See protein sequence)

Recommended Name: Dynein heavy chain 14, axonemal

Size: 3507 amino acids; 399895 Da

Subunit: Consists of at least two heavy chains and a number of intermediate and light chains

Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme (Potential)

Sequence caution: Sequence=AAI19717.1; Type=Erroneous initiation; Sequence=AAI19718.1; Type=Erroneous initiation;

Sequence=CAI95150.2; Type=Erroneous gene model prediction; Sequence=CAI95641.1; Type=Erroneous gene model

prediction; Sequence=CAI95642.2; Type=Erroneous gene model prediction; Sequence=EAW69735.1; Type=Erroneous gene

model prediction;

Secondary accessions: A6NG62 A6NNL2 Q0VDD9 Q4VXC7 Q4VXG4 Q4VXG5 Q5VU33 Q5VU34

Alternative splicing: 4 isoforms: Q0VDD8-1 Q0VDD8-2 Q0VDD8-3 Q0VDD8-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAH14: NX_Q0VDD8

Explore proteomics data for DNAH14 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q0VDD8

DNAH14 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138626.1 NP_001364.1 NP_659426.2

ENSEMBL proteins:

ENSP00000409472 ENSP00000412969 ENSP00000383737 ENSP00000355814 ENSP00000355813

ENSP00000392061 ENSP00000409971 ENSP00000332424 ENSP00000429568 ENSP00000429122

ENSP00000328980 ENSP00000398678 ENSP00000414699 ENSP00000414402 ENSP00000355815

Human Recombinant Protein Products for DNAH14:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for DNAH14
	GenScript Custom Purified and Recombinant Proteins Services for DNAH14
	Novus Biologicals DNAH14 Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DNAH14

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005874	microtubule	IEA	--
GO:0030286	dynein complex	IEA	--
GO:0035085	cilium axoneme	IEA	--

DNAH14 for ontologies About GeneDecksing

DNAH14 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DNAH14
	GenScript Custom Superior Antibodies Services for DNAH14
	Novus Biologicals DNAH14 Antibodies
	Abcam antibodies for DNAH14
	Cloud-Clone Corp. Antibodies for DNAH14
	Search ThermoFisher Antibodies for DNAH14
	Search LSBio for Antibodies for DNAH14

Assay Products for DNAH14:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DNAH14
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DNAH14
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DNAH14 Cloud-Clone Corp. CLIAs for DNAH14

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

DN: Axonemal dyneins

5 InterPro protein domains:

IPR004273 Dynein_heavy_dom

IPR024317 Dynein_heavy_chain_D4_dom

IPR024743 Dynein_HC_stalk

IPR027417 P-loop_NTPase

IPR026983 DHC_fam

Graphical View of Domain Structure for InterPro Entry Q0VDD8

ProtoNet protein and cluster: Q0VDD8

UniProtKB/Swiss-Prot: DYH14_HUMAN, Q0VDD8

Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other

dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head,

which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and

AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not

clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two

non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes

ATP, the others may serve a regulatory function (By similarity)

Similarity: Belongs to the dynein heavy chain family

DNAH14 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DYH14_HUMAN, Q0VDD8

Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.

Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in

sperm motility; implicated in sperm flagellar assembly (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0003777	microtubule motor activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0017111	nucleoside-triphosphatase activity	--	--

DNAH14 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DNAH14:

Elongated cells

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAH14

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNAH14

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAH14

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAH14

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAH14
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DNAH14
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DNAH14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAH14

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DNAH14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for DNAH14 (see all 9) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): DNAH14 (NM_001373)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAH14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAH14

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNAH14
		Search LifeMap BioReagents cell lines for DNAH14

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH14

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for DNAH14 About

See pathways by source

SuperPath

Contained pathways About

Cytoskeleton remodeling Neurofilaments

Cytoplasmic microtubules

0.32

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for DNAH14

Cytoplasmic microtubules

DNAH14 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNAH14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for DNAH14 (ENSP00000414402⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCTN2	ENSP00000408910⁴	STRING: ENSP00000408910
DNAH1	ENSP00000401514⁴	STRING: ENSP00000401514
DNAH10	ENSP00000386770⁴	STRING: ENSP00000386770
DNAH12	ENSP00000295937⁴	STRING: ENSP00000295937
DNAH17	ENSP00000374490⁴	STRING: ENSP00000374490

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007018	microtubule-based movement	IEA	--

DNAH14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNAH14 (DYH14)

Search CenterWatch for drugs/clinical trials and news about DNAH14 / DYH14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNAH14 gene (3 alternative transcripts):

NM_001145154.1 NM_001373.1 NM_144989.2

Unigene Cluster for DNAH14:

Dynein, axonemal, heavy chain 14

Hs.133977 [show with all ESTs]

Unigene Representative Sequence: NM_001373

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000445597 ENST00000413949 ENST00000400952(uc001hou.4 uc001hot.4)

ENST00000366849 ENST00000498360 ENST00000366848 ENST00000486657 ENST00000439375

ENST00000433124 ENST00000453375 ENST00000474127 ENST00000328556 ENST00000474801

ENST00000495456 ENST00000327794(uc001hox.2) ENST00000450490 ENST00000428003

ENST00000430092(uc001how.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAH14
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DNAH14
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for DNAH14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAH14

Clone Products:		OriGene clones in human, mouse for DNAH14 (see all 9) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): DNAH14 (NM_001373)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAH14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAH14

Primer Products:		OriGene qPCR primer pairs and template standards for DNAH14 OriGene qSTAR qPCR primer pairs in human, mouse for DNAH14
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat DNAH14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAH14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAH14

Additional mRNA sequence:

BC017415.2 BC042869.1 BC119716.1 BC119717.1 CR936804.1 U61741.1

12 DOTS entries:

DT.441681 DT.121397237 DT.121360822 DT.100748266 DT.40300276 DT.65287590 DT.121457981 DT.40237275

DT.121448792 DT.91885421 DT.95208396 DT.95241586

24/28 AceView cDNA sequences (see all 28):

BG211987 BG217954 BG214278 AI015591 BG199089 BG216491 BG219476 BG186731

BG221427 BG190449 BG210654 BG206371 BG198565 BG199613 BG213686 BG204743

BG195015 BG202710 BG220952 BG208980 BG191945 BG198162 BG190928 BG202709

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNAH14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTATTTAATA

About this image

See DNAH14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAH14

SOURCE GeneReport for Unigene cluster: Hs.133977

SABiosciences Custom PCR Arrays for DNAH14

Primer Products:		OriGene qPCR primer pairs and template standards for DNAH14 OriGene qSTAR qPCR primer pairs in human, mouse for DNAH14
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat DNAH14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAH14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAH14

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DNAH14 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dnahc14^{1 , 5}	dynein, axonemal, heavy chain 14^{1, 5}	72.33(n)¹ 63.53(a)¹		1 (84.83 cM)⁵ 240960¹ XM_003688772.1¹ XP_003688820.1¹ 181738988⁵
chicken (Gallus gallus)	Aves	C1ORF67⁶	Uncharacterized protein	27(a)	1 ↔ 1	3(16773684-16784549)

ENSEMBL Gene Tree for DNAH14 (if available)
TreeFam Gene Tree for DNAH14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNAH14 gene

16 SIMAP similar genes for DNAH14 using alignment to 11 protein entries: DYH14_HUMAN (see all proteins):

DNAH6 Dnahc3 DNAH2 DNAH5 DNAH17 DNAH9

Dnahc9 DYNC1H1 Dnchc1 DYNC2H1 Dnahc11 DNAH11

DNAH8 DNAH10 DNAH12 DNAH1

DNAH14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58030730^1,2	C	--	195693346(+)	`ACAGA-/GACAGA CCTGA`	2	--	int¹		1		NA	2
rs34138211^1,2	C	--	195756427(+)	`CTATC-/T/TATC AATCA`	1	--	int¹		1		NA	2
rs71170062^1,2	C	--	195890699(-)	`TTAAT-/TCTGTTT`	1	--	int¹		1		NA	2
rs148910532^1,2	C	--	225115398(+)	`GTTTAC/TTGCAG`	3	--	us2k¹		0	--	--	--	--
rs192935622^1,2		--	225115419(+)	`AATAGC/TGAAGA`	3	--	us2k¹		0	--	--	--	--
rs144976350^1,2	C	--	225115420(+)	`ATAGCA/GAAGAC`	3	--	us2k¹		0	--	--	--	--
rs148025495^1,2		--	225115425(+)	`GAAGAC/TATGGA`	3	--	us2k¹		0	--	--	--	--
rs140537388^1,2	C	--	225115506(+)	`TGCAGA/CCATAA`	3	--	us2k¹		0	--	--	--	--
rs184127320^1,2		--	225115608(+)	`CTGCAA/CGTTCT`	3	--	us2k¹		0	--	--	--	--
rs187865269^1,2		--	225115621(+)	`CTCGTA/GAGTGG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNAH14 (225083964 - 225333964 bp, first 250kb of DNAH14)

Structural Variations
Database of Genomic Variants (DGV) 10/32 variations for DNAH14 (see all 32): About this table

Variant ID	Type	Subtype	PubMed ID
esv2673679	CNV	Deletion	23128226
esv2723817	CNV	Deletion	23290073
esv2367547	CNV	Deletion	18987734
esv2723850	CNV	Deletion	23290073
esv4999	CNV	Deletion	18987735
esv2511976	CNV	Deletion	19546169
esv2607015	CNV	Deletion	19546169
esv2723839	CNV	Deletion	23290073
esv2552398	CNV	Deletion	19546169
esv2723861	CNV	Deletion	23290073

Human Gene Mutation Database (HGMD): DNAH14

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing DNAH14

DNA2.0 Custom Variant and Variant Library Synthesis for DNAH14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 603341 OMIM disorders: --

6 diseases for DNAH14: About MalaCards

tyrosinemia primary ciliary dyskinesia situs inversus biliary atresia

lateral sclerosis amyotrophic lateral sclerosis

1 disease from the University of Copenhagen DISEASES database for DNAH14:

Primary ciliary dyskinesia

DNAH14 for disorders About GeneDecksing

Export disorders for DNAH14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNAH14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNAH14)

Utopia: connect your pdf to the dynamic
world of online information

Multiple mouse chromosomal loci for dynein-based motility. (PubMed id 8812413)^{1, 3} Vaughan K.T....Vallee R.B. (1996)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 127602	HGNC: 2945	AceView: LOC127602	Ensembl:ENSG00000185842	euGenes: HUgn127602
ECgene: DNAH14	H-InvDB: DNAH14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DNAH14	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNAH14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DNAH14 gene:
Search GeneIP for patents involving DNAH14

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for DNAH14
	OriGene qPCR primer pairs and template standards for DNAH14		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for DNAH14
	OriGene qSTAR qPCR primer pairs in human, mouse for DNAH14		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DNAH14		OriGene Custom Protein Services for DNAH14

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAH14
	QIAGEN SeqTarget long-range PCR primers for resequencing DNAH14
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAH14
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAH14
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAH14
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAH14

	GenScript Custom Purified and Recombinant Proteins Services for DNAH14		GenScript cDNA clones with any tag delivered in your preferred vector for DNAH14
	GenScript Custom Assay Services for DNAH14		GenScript Custom Superior Antibodies Services for DNAH14
	GenScript Custom overexpressing Cell Line Services for DNAH14		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DNAH14 promoter
	Search Chromatin IP Primers for DNAH14
	RT² qPCR Primer Assay in human, mouse / rat DNAH14
	Search GNC Networks for DNAH14
	SABiosciences Custom PCR Arrays for DNAH14

Search Tocris compounds for DNAH14 (DYH14)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DNAH14 antibodies
	DNAH14 proteins

	Antibodies for DNAH14
	See all of Abcam's Antibodies, Kits and Proteins for DNAH14
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DNAH14
	Antibodies for DNAH14
	ELISAs for DNAH14
	CLIAs for DNAH14

Search LifeMap BioReagents cell lines for DNAH14

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH14

	Browse SwitchGear 3'UTR luciferase reporter plasmids for DNAH14
	Browse SwitchGear Promoter luciferase reporter plasmids for DNAH14

Search ThermoFisher Antibodies for DNAH14

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAH14

	inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAH14
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNAH14

Customized:

	lentivirus for stable overexpression
	lentivirus expression plasmids for stable overexpression
	adenovirus for overexpression

Search LSBio for Antibodies for DNAH14

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DNAH14 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

DNAH14 Gene

Dynein, Axonemal, Heavy Chain 14

Aliases
for DNAH14 gene

Summaries
for DNAH14 gene

Genomic Views
for DNAH14 gene

Proteins
for DNAH14 gene

Protein Domains /
Families
for DNAH14 gene

Function
for DNAH14 gene

Pathways & Interactions
for DNAH14 gene

Drugs & Compounds
for DNAH14 gene

Transcripts
for DNAH14 gene

Expression
for DNAH14 gene

Orthologs
for DNAH14 gene

Paralogs
for DNAH14 gene

Genomic Variants
for DNAH14 gene

Disorders / Diseases
for DNAH14 gene

Publications
for DNAH14 gene

External Searches for DNAH14 gene

Genome Databases showing DNAH14 gene

Other Databases showing DNAH14 gene

Specialized Databases showing DNAH14 gene

Intellectual Property
for DNAH14 gene

Products
for DNAH14 gene

View Random Gene

Advanced Search

Export list of displayed genes

DNAH14 Gene

Dynein, Axonemal, Heavy Chain 14

Aliasesfor DNAH14 gene

Summariesfor DNAH14 gene

Genomic Viewsfor DNAH14 gene

Proteinsfor DNAH14 gene

Protein Domains /Familiesfor DNAH14 gene

Functionfor DNAH14 gene

Pathways & Interactionsfor DNAH14 gene

Drugs & Compoundsfor DNAH14 gene

Transcriptsfor DNAH14 gene

Expression for DNAH14 gene

Orthologsfor DNAH14 gene

Paralogsfor DNAH14 gene

Genomic Variantsfor DNAH14 gene

Disorders / Diseasesfor DNAH14 gene

Publicationsfor DNAH14 gene

External Searches for DNAH14 gene

Genome Databases showing DNAH14 gene

Other Databases showing DNAH14 gene

Specialized Databases showing DNAH14 gene

Intellectual Propertyfor DNAH14 gene

Productsfor DNAH14 gene

View Random Gene

Aliases
for DNAH14 gene

Summaries
for DNAH14 gene

Genomic Views
for DNAH14 gene

Proteins
for DNAH14 gene

Protein Domains /
Families
for DNAH14 gene

Function
for DNAH14 gene

Pathways & Interactions
for DNAH14 gene

Drugs & Compounds
for DNAH14 gene

Transcripts
for DNAH14 gene

Expression
for DNAH14 gene

Orthologs
for DNAH14 gene

Paralogs
for DNAH14 gene

Genomic Variants
for DNAH14 gene

Disorders / Diseases
for DNAH14 gene

Publications
for DNAH14 gene

Intellectual Property
for DNAH14 gene

Products
for DNAH14 gene