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DNAH12 Gene

protein-coding   GIFtS: 47
GCID: GC03M057406

Dynein, Axonemal, Heavy Chain 12

(Previous names: dynein, axonemal, heavy polypeptide 12, dynein heavy chain...)
(Previous symbols: DNHD2, DNAH12L, DNAH7L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Heavy Chain 121 2     Dynein Heavy Chain Domain 21
DNAH12L1 2 3     Dynein Heavy Domain 21
DNAH7L1 2 3     Dynein, Axonemal, Heavy Chain 12-Like1
DNHD21 2 3     Dynein, Axonemal, Heavy Chain 7-Like1
DNAHC32 3 5     DNAHC122
HL192 3 5     HL-192
Dynein, Axonemal, Heavy Polypeptide 121 2     Axonemal Dynein Heavy Chain Isotype32
Axonemal Beta Dynein Heavy Chain 122 3     Dynein Heavy Chain 12, Axonemal2
Ciliary Dynein Heavy Chain 122 3     Dynein, Heavy Chain-52
Dynein Heavy Chain Domain-Containing Protein 22 3     Axonemal Dynein Heavy Chain 12-Like Protein3
DHC32 3     Axonemal Dynein Heavy Chain 7-Like Protein3
DLP122 3     Dynein Heavy Chain 7-Like, Axonemal3
HDHC32 3     

External Ids:    HGNC: 29431   Entrez Gene: 2016252   Ensembl: ENSG000001748447   OMIM: 6033405   UniProtKB: Q6ZR083   

Export aliases for DNAH12 gene to outside databases

Previous GC identifers: GC03M056215 GC03M056785 GC03M057285 GC03M057388 GC03U900611 GC03M057432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAH12 Gene:
DNAH12 (dynein, axonemal, heavy chain 12) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity and ATPase activity.

UniProtKB/Swiss-Prot: DYH12_HUMAN, Q6ZR08
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in
sperm motility; implicated in sperm flagellar assembly (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAH12 gene promoter:
         USF-1   Nkx2-2   Zic1   POU6F1 (c2)   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAH12 promoter sequence
   Search Chromatin IP Primers for DNAH12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAH12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21.1

DNAH12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAH12 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M057406:  view genomic region     (about GC identifiers)

Start:
57,327,727 bp from pter      End:
57,530,071 bp from pter
Size:
202,345 bases      Orientation:
minus strand

1 alternative location:
Chr3-,NW_003315911 16,574-78,468     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DYH12_HUMAN, Q6ZR08 (See protein sequence)
Recommended Name: Dynein heavy chain 12, axonemal  
Size: 3092 amino acids; 356942 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Caution: Was originally derived from a readthrough transcript including ASB14 and DNAH12. DNHD2 was thought to be
a distinct gene
Sequence caution: Sequence=AAB09729.1; Type=Frameshift; Positions=1211, 1213, 1215;
Secondary accessions: A6NGI2 Q6ZTR8 Q8N7R9 Q8WXK2 Q92816
Alternative splicing: 4 isoforms:  Q6ZR08-1   Q6ZR08-4   Q6ZR08-2   Q6ZR08-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAH12: NX_Q6ZR08

Explore proteomics data for DNAH12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAH12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_848599.3  NP_940966.2  

    ENSEMBL proteins: 
     ENSP00000420554   ENSP00000420717   ENSP00000420359   ENSP00000418137   ENSP00000374187  
     ENSP00000312554   ENSP00000295937   ENSP00000340464  

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    antibodies-online antibodies for DNAH12 (4 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DN: Axonemal dyneins

    Selected InterPro protein domains (see all 7):
     IPR004273 Dynein_heavy_dom
     IPR024317 Dynein_heavy_chain_D4_dom
     IPR011704 ATPase_dyneun-rel_AAA
     IPR013602 Dynein_heavy_dom-2
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q6ZR08

    ProtoNet protein and cluster: Q6ZR08

    UniProtKB/Swiss-Prot: DYH12_HUMAN, Q6ZR08
    Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other
    dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head,
    which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and
    AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not
    clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two
    non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes
    ATP, the others may serve a regulatory function (By similarity)
    Similarity: Belongs to the dynein heavy chain family


    Find genes that share domains with DNAH12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYH12_HUMAN, Q6ZR08
    Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
    Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in
    sperm motility; implicated in sperm flagellar assembly (By similarity)

         Genatlas biochemistry entry for DNAH12:
    dynein,axonemal,motor protein interacting with microtubules,heavy chain 12,predominantly expressed in trachea and
    testis,involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle
    apparatus,with ATPase activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IEA--
    GO:0017111nucleoside-triphosphatase activity ----
         
    Find genes that share ontologies with DNAH12           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DNAH12

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYH12_HUMAN, Q6ZR08: Cytoplasm, cytoskeleton, cilium axoneme (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    endosome1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005929cilium IEA--
    GO:0030286dynein complex IEA--

    Find genes that share ontologies with DNAH12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAH12
    Interactions:

        Search GeneGlobe Interaction Network for DNAH12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAH12 (ENSP000002959374) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN2ENSP000004089104STRING: ENSP00000408910
    DNAH1ENSP000004015144STRING: ENSP00000401514
    DNAH10ENSP000003867704STRING: ENSP00000386770
    DNAH14ENSP000004144024STRING: ENSP00000414402
    DNAH17ENSP000003744904STRING: ENSP00000374490
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement IEA--

    Find genes that share ontologies with DNAH12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAH12 (DYH12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAH12 gene (2 alternative transcripts): 
    NM_178504.4  NM_198564.3  

    Unigene Cluster for DNAH12:

    Dynein, axonemal, heavy chain 12
    Hs.201378  [show with all ESTs]
    Unigene Representative Sequence: NM_178504
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462199(uc010hnc.2) ENST00000462713 ENST00000494758 ENST00000479363
    ENST00000466540 ENST00000495027 ENST00000389536 ENST00000311202(uc003diu.2)
    ENST00000351747(uc003dit.2) ENST00000344804
    miRNA
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    Additional mRNA sequence: 

    AK097746.1 AK126276.1 AK128592.1 U53532.1 U61739.1 Z83802.1 

    15 DOTS entries:

    DT.95182652  DT.101975873  DT.95330640  DT.40281381  DT.97817310  DT.91742161  DT.99962580  DT.100735028 
    DT.120897565  DT.100020371  DT.120849697  DT.120907258  DT.120910527  DT.120919906  DT.40127276 

    Selected AceView cDNA sequences (see all 27):

    CN478898 BE044379 BM975826 BU677370 BU686274 CD557821 AK097746 AW070294 
    CB851845 BG209757 BU679845 BU607925 AI005163 AW182837 CB854608 BG199370 
    BQ045249 AI982970 BX104748 AI682599 BG194753 BG216642 NM_178504 BG221161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAH12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACTGTGT
    DNAH12 Expression
    About this image


    DNAH12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    DNAH12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAH12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.201378
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAH12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnahc125
    Dnah121
    dynein, axonemal, heavy chain 121, 5 86.34(n)1
    87.3(a)1
      14 (16.09 cM)5
    1100831  XM_006519759.11  XP_006519822.11 
     266932745 
    chicken
    (Gallus gallus)
    Aves DNAH121 dynein, axonemal, heavy chain 12 73.32(n)
    74.08(a)
      416004  XM_414346.4  XP_414346.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnah121 dynein, axonemal, heavy chain 12 69.13(n)
    74.77(a)
      100216154  XM_004914173.1  XP_004914230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.216492 Transcribed sequence with weak similarity to protein refNP_061720.1 (H.sapiens) axonemal dynein heavy chain 7 [Homo sapiens] less 77.04(n)    57048927 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dhc62B1 Dynein heavy chain at 62B 50.63(n)
    46.75(a)
      38226  NM_206236.3  NP_995958.2 


    ENSEMBL Gene Tree for DNAH12 (if available)
    TreeFam Gene Tree for DNAH12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAH12 gene
    13 SIMAP similar genes for DNAH12 using alignment to 6 protein entries:     DYH12_HUMAN (see all proteins):
    Dnahc3    Dnahc11    Dnahc9    DNAH5    Dnchc1    DNAH10
    DNAH7    DNAH14    DNAH1    DNAH2    DNAH3    DNAH9
    DNAH11

    Find genes that share paralogs with DNAH12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DNAH12
    PGOHUM00000262865


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAH12 (see all 4324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504981921,2
    C,Funtested157528437(+) ACTGAA/G/TTAATT 4 N I mis11NA 4544
    rs46819681,2
    C,F,H--57328867(+) GTCACG/TTTTCT 1 -- int120Minor allele frequency- T:0.14NA NS EA WA 1828
    rs177919631,2
    C,F--57328906(+) TGAGAA/CTATTT 1 -- int13Minor allele frequency- C:0.01NA 142
    rs1379548471,2
    --57329085(+) TGGGG-/CAAAAT 1 -- int10--------
    rs607018681,2
    C,F--57329275(+) GTTCAA/GTCTGT 1 -- int14Minor allele frequency- G:0.21NA WA 242
    rs1926236621,2
    C--57329299(+) GAAGTG/TGGGGG 1 -- int10--------
    rs1825867891,2
    --57329541(+) GTTGAA/GAGAAT 1 -- int10--------
    rs1877257901,2
    --57329684(+) AGATTC/GCTACT 1 -- int10--------
    rs1924987971,2
    --57329857(+) AATGAC/TTGTCC 1 -- int10--------
    rs1851142511,2
    --57329884(+) AAGGGA/TAACTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNAH12 (57327727 - 57530071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DNAH12 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673906CNV Deletion23128226
    esv2470376CNV Deletion19546169
    esv2658591CNV Deletion23128226
    esv2517054CNV Deletion19546169
    esv2725309CNV Deletion23290073
    esv1990047CNV Deletion18987734
    nsv508931CNV Insertion20534489
    nsv3836CNV Insertion18451855
    dgv5142n71CNV Loss21882294
    nsv460558CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603340    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DNAH12:
    Primary ciliary dyskinesia

    Find genes that share disorders with DNAH12           About GenesLikeMe

    Genetic Association Database (GAD): DNAH12
    Human Genome Epidemiology (HuGE) Navigator: DNAH12 (2 documents)

    Export disorders for DNAH12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAH12 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DNAH12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles. (PubMed id 8666668)1, 2, 3 Vaisberg E.A.... McIntosh J.R. (J. Cell Biol. 1996)
    2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (PLoS ONE 2010)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Multiple mouse chromosomal loci for dynein-based motility. (PubMed id 8812413)1, 3 Vaughan K.T....Vallee R.B. (Genomics 1996)
    8. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)
    9. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)
    10. Dynein is required for receptor sorting and the morphogenesis of early endosomes. (PubMed id 17173037)1 Driskell O.J....Woodman P.G. (Nat. Cell Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201625 HGNC: 2943 AceView: FLJ40427 Ensembl:ENSG00000174844 euGenes: HUgn201625
    ECgene: DNAH12 H-InvDB: DNAH12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAH12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAH12 gene:
    Search GeneIP for patents involving DNAH12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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