Aliases for DNAH11 Gene
External Ids for DNAH11 Gene
Previous GeneCards Identifiers for DNAH11 Gene
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
GeneCards Summary for DNAH11 Gene
DNAH11 (Dynein, Axonemal, Heavy Chain 11) is a Protein Coding gene. Diseases associated with DNAH11 include primary ciliary dyskinesia 7: dnah11-related primary ciliary dyskinesia and ciliary dyskinesia, primary, 7, with or without situs inversus. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.
UniProtKB/Swiss-Prot for DNAH11 Gene
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP