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Aliases for DNAH10 Gene

Aliases for DNAH10 Gene

  • Dynein, Axonemal, Heavy Chain 10 2 3
  • Dynein, Axonemal, Heavy Polypeptide 10 2
  • Axonemal Beta Dynein Heavy Chain 10 4
  • Ciliary Dynein Heavy Chain 10 4
  • KIAA2017 4

External Ids for DNAH10 Gene

Previous GeneCards Identifiers for DNAH10 Gene

  • GC13U990058
  • GC12P124029
  • GC12P122599
  • GC12P122658
  • GC12P122902
  • GC12P122792
  • GC12U900526
  • GC12P124247
  • GC12P121208

Summaries for DNAH10 Gene

Entrez Gene Summary for DNAH10 Gene

  • Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAH10 Gene

DNAH10 (Dynein, Axonemal, Heavy Chain 10) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH1.

UniProtKB/Swiss-Prot for DNAH10 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAH10 Gene

Genomics for DNAH10 Gene

Regulatory Elements for DNAH10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAH10 Gene

Start:
123,762,188 bp from pter
End:
123,936,206 bp from pter
Size:
174,019 bases
Orientation:
Plus strand

Genomic View for DNAH10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAH10 Gene

Proteins for DNAH10 Gene

  • Protein details for DNAH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF4-DYH10_HUMAN
    Recommended name:
    Dynein heavy chain 10, axonemal
    Protein Accession:
    Q8IVF4
    Secondary Accessions:
    • C9JMF5
    • O95495
    • Q6ZUC9
    • Q6ZUP6
    • Q8N761

    Protein attributes for DNAH10 Gene

    Size:
    4471 amino acids
    Molecular mass:
    514841 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains
    SequenceCaution:
    • Sequence=BAC04579.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86296.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAH10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAH10 Gene

Proteomics data for DNAH10 Gene at MOPED

Post-translational modifications for DNAH10 Gene

  • Glycosylation at Asn1074
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAH10 Gene

No data available for DME Specific Peptides for DNAH10 Gene

Domains for DNAH10 Gene

Gene Families for DNAH10 Gene

HGNC:
  • DN :Axonemal dyneins

Suggested Antigen Peptide Sequences for DNAH10 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVF4

UniProtKB/Swiss-Prot:

DYH10_HUMAN :
  • Q8IVF4
Domain:
  • Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).
Family:
  • Belongs to the dynein heavy chain family.
Similarity:
  • Contains 5 TPR repeats.
genes like me logo Genes that share domains with DNAH10: view

Function for DNAH10 Gene

Molecular function for DNAH10 Gene

UniProtKB/Swiss-Prot Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.

Gene Ontology (GO) - Molecular Function for DNAH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with DNAH10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAH10 Gene

Localization for DNAH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAH10 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAH10 Gene COMPARTMENTS Subcellular localization image for DNAH10 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DNAH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
GO:0030286 dynein complex IEA --
genes like me logo Genes that share ontologies with DNAH10: view

Pathways for DNAH10 Gene

SuperPathways for DNAH10 Gene

No Data Available

Interacting Proteins for DNAH10 Gene

Gene Ontology (GO) - Biological Process for DNAH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DNAH10: view

No data available for Pathways by source for DNAH10 Gene

Transcripts for DNAH10 Gene

mRNA/cDNA for DNAH10 Gene

(6) Additional mRNA sequences :
(10) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAH10 Gene

Dynein, axonemal, heavy chain 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAH10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNAH10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAH10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

ExUns: 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DNAH10 Gene

GeneLoc Exon Structure for
DNAH10
ECgene alternative splicing isoforms for
DNAH10

Expression for DNAH10 Gene

mRNA expression in normal human tissues for DNAH10 Gene

mRNA differential expression in normal tissues according to GTEx for DNAH10 Gene

This gene is overexpressed in Testis (8.5) and Fallopian Tube (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAH10 Gene

SOURCE GeneReport for Unigene cluster for DNAH10 Gene Hs.622654

mRNA Expression by UniProt/SwissProt for DNAH10 Gene

Q8IVF4-DYH10_HUMAN
Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart
genes like me logo Genes that share expressions with DNAH10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DNAH10 Gene

Orthologs for DNAH10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAH10 35
  • 98.72 (n)
  • 98.45 (a)
DNAH10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAH10 35
  • 87.49 (n)
  • 91.13 (a)
DNAH10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAH10 35
  • 87.94 (n)
  • 91.19 (a)
DNAH10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnah10 35
  • 81.27 (n)
  • 88.12 (a)
Dnah10 36
  • 86 (a)
OneToOne
Dnahc10 16
oppossum
(Monodelphis domestica)
Mammalia DNAH10 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAH10 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnah10 35
  • 81.26 (n)
  • 88.35 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
ManyToMany
DNAH10 35
  • 71.2 (n)
  • 73.83 (a)
lizard
(Anolis carolinensis)
Reptilia DNAH10 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7994 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnah10 35
  • 71.37 (n)
  • 77.84 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-86b9.1 35
  • 67.65 (n)
  • 71.04 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001660 35
  • 57.42 (n)
  • 53.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dhc98D 35
  • 56.09 (n)
  • 51.8 (a)
Dhc98D 36
  • 44 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7110 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToOne
Species with no ortholog for DNAH10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAH10 Gene

ENSEMBL:
Gene Tree for DNAH10 (if available)
TreeFam:
Gene Tree for DNAH10 (if available)

Paralogs for DNAH10 Gene

Selected SIMAP similar genes for DNAH10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DNAH10: view

Variants for DNAH10 Gene

Sequence variations from dbSNP and Humsavar for DNAH10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs925772 -- 123,801,610(-) CTTAT(C/G)TTCAT intron-variant
rs1022320 -- 123,779,772(-) TAGAG(C/G)TGCCC intron-variant
rs1022321 -- 123,779,730(-) TGCAG(C/T)TGAAG intron-variant
rs1114628 -- 123,795,810(-) ccAGA(A/C)CTGTG intron-variant
rs1114629 -- 123,795,774(-) CTCGT(G/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAH10 Gene

Variant ID Type Subtype PubMed ID
nsv522321 CNV Loss 19592680
nsv915 CNV Insertion 18451855
nsv509484 CNV Insertion 20534489
esv2746513 CNV Deletion 23290073
esv2746514 CNV Deletion 23290073
esv29401 CNV Gain+Loss 19812545
esv1783084 CNV Insertion 17803354
esv998816 CNV Insertion 20482838

Relevant External Links for DNAH10 Gene

HapMap Linkage Disequilibrium report
DNAH10
Human Gene Mutation Database (HGMD)
DNAH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAH10 Gene

Disorders for DNAH10 Gene

Relevant External Links for DNAH10

Genetic Association Database (GAD)
DNAH10
Human Genome Epidemiology (HuGE) Navigator
DNAH10
genes like me logo Genes that share disorders with DNAH10: view

No data available for UniProtKB/Swiss-Prot for DNAH10 Gene

Publications for DNAH10 Gene

  1. Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes. (PMID: 11175280) Maiti A.K. … Bouvagnet P. (Eur. J. Hum. Genet. 2000) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman D.I. … Ridker P.M. (PLoS Genet. 2009) 3 48
  4. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z. … Kathiresan S. (PLoS Genet. 2012) 3
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for DNAH10 Gene

Sources for DNAH10 Gene

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