DNAH1 Gene
protein-coding GIFtS: 53
GCID: GC03P052350
|
|
dynein, axonemal, heavy chain 1(Previous names: dynein, axonemal, heavy polypeptide 1 )
| |
Aliases
for DNAH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dynein, Axonemal, Heavy Chain 11 2 | | HSRF-12 3 | | DNAHC11 2 3 5 | | DNAH1 Variant Protein2 | | HDHC71 2 5 | | Dynein Heavy Chain 1, Axonemal2 | | HL111 2 5 | | Heat Shock Regulated 12 | | HL-111 2 | | DHC73 | | XLHSRF-11 2 | | KIAA14103 | | Dynein, Axonemal, Heavy Polypeptide 11 2 | | HDHC71 2 5 | | Axonemal Beta Dynein Heavy Chain 12 3 | | EC 1.1.1.2058 | | Ciliary Dynein Heavy Chain 12 3 | | EC 2.5.1.88 | | Heat Shock Regulated Protein 12 3 | | |
Export aliases for DNAH1 gene to outside databasesPrevious GC identifers: GC03U990024 GC03P052244 GC07P021439 GC07P021384 GC03P052325 |
Summaries
for DNAH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DYH1_HUMAN, Q9P2D7Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dyneinhas ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in spermmotility; implicated in sperm flagellar assembly (By similarity)
|
Genomic Views
for DNAH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAH1 gene promoter:
ER-alpha Elk-1 SREBP-1c Tal-1beta SREBP-1b E47 AREB6 Ik-2 SREBP-1a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21-p14DNAH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P052350: view genomic region
(about GC identifiers)
Start:
|
52,350,335 bp from pter |
End:
|
52,434,513 bp from pter |
Size:
|
84,179 bases |
Orientation:
|
plus strand |
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Proteins
for DNAH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DYH1_HUMAN, Q9P2D7 (See
protein sequence)Recommended Name: Dynein heavy chain 1, axonemal Size: 4330 amino acids; 493953 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme (Potential)
Sequence caution: Sequence=BAA92648.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAB14671.1; Type=Frameshift; Positions=4190; Sequence=BAB84956.2; Type=Miscellaneous discrepancy; Note=Wrongchoice of CDS; Sequence=CAB06058.1; Type=Frameshift; Positions=1595;
Secondary accessions: B0I1R6 O00436 O15435 O95491 Q6ZU48 Q86YK7 Q8TEJ4 Q92863 Q9H8E6 Q9UFW6 Q9Y4Z7Alternative splicing: 5 isoforms: Q9P2D7-1 Q9P2D7-2 Q9P2D7-3 Q9P2D7-4 Q9P2D7-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DNAH1: NX_Q9P2D7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2D7
2 DME Specific Peptides for DNAH1 (Q9P2D7)
DNAH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056327.4
ENSEMBL proteins: ENSP00000401514 ENSP00000417542 ENSP00000419071 ENSP00000418688
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DNAH1 for ontologies About GeneDecksing
DNAH1 Antibody Products:
Assay Products for DNAH1: |
Protein
Domains /
Families
for DNAH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAH1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9P2D7ProtoNet protein and cluster: Q9P2D7 2 Blocks protein families: IPB004273 Dynein heavy chain IPB011704 ATPase associated with various cellular activities
UniProtKB/Swiss-Prot: DYH1_HUMAN, Q9P2D7Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dyneincomponents), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which forma ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 andterminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whetherthe N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPasesites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve aregulatory function (By similarity)Similarity: Belongs to the dynein heavy chain family |
Function
for DNAH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DYH1_HUMAN, Q9P2D7Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dyneinhas ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in spermmotility; implicated in sperm flagellar assembly (By similarity) Genatlas biochemistry entry for DNAH1:dynein,axonemal,motor protein interacting with microtubules,heavy chain 1,inner arm,expressed in testis,involved inintracellular movement of organelles and vesicles or in the orientation of the mitotic spindle apparatus,with ATPaseactivity
Enzyme Numbers (IUBMB): EC 2.5.1.82 EC 1.1.1.2052
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAH1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAH1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAH1 (NM_173628) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAH1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DNAH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DNAH1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Dnahc1tm1Ihgg for DNAH1
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dnahc1):
DNAH1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DNAH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Cytoskeleton remodeling Neurofilaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DNAH1
1 
Kegg Pathway (Kegg details for DNAH1):
DNAH1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAH1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for DNAH1 (Q9P2D73 ENSP000004015144) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
DNAH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAH1
Search CenterWatch for drugs/clinical trials and news about DNAH1 / DYH1
|
Transcripts
for DNAH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAH1 gene: NM_015512.4 Unigene Cluster for DNAH1: Dynein, axonemal, heavy chain 1 Hs.655469 [show with all ESTs]Unigene Representative Sequence: AB2901639 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486752(uc003ddv.3) ENST00000420323(uc011bef.2) ENST00000497875(uc003ddt.1)
ENST00000491454 ENST00000466628 ENST00000488988 ENST00000490713 ENST00000480649
ENST00000487254
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAH1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAH1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAH1 (NM_173628) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAH1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DNAH1 |
Additional cDNA sequence: AB037831.3 AB290163.1 AJ132083.1 AK023766.1 AK074130.2 AK093347.1 AK125990.1 AL117428.1 AL832045.1 AY221994.1 HQ013243.1 U61738.1 Z83804.1 7 DOTS entries: DT.209675 DT.97858397 DT.95164600 DT.95217463 DT.91667380 DT.99927595 DT.91667381
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DNAH1 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46a | · | 46b | ^ |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 47 | ^ | 48 | ^ | 49 | ^ | 50 | ^ | 51 | ^ | 52 | ^ | 53 | ^ | 54 | ^ | 55a | · | 55b | ^ | 56 | ^ | 57 | ^ | 58 | ^ | 59 | ^ | 60a | · | 60b | ^ | 61a | · | 61b | ^ | 62 | ^ | 63a | · | 63b | ^ | 64a | · | 64b | ^ | 65 | ^ | 66a | · | 66b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
| ExUns: | 67a | · | 67b | ^ | 68 | ^ | 69a | · | 69b | ^ | 70 | ^ | 71 | ^ | 72a | · | 72b | ^ | 73 | ^ | 74a | · | 74b | ^ | 75 | ^ | 76 | ^ | 77a | · | 77b | ^ | 78 | ^ | 79a | · | 79b | · | 79c | ^ | 80a | · | 80b | · | 80c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNAH1
|
Expression
for DNAH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTATTCCT
About this image
See DNAH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAH1
SOURCE GeneReport for Unigene cluster: Hs.655469
UniProtKB/Swiss-Prot: DYH1_HUMAN, Q9P2D7Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressedin brain
SABiosciences Custom PCR Arrays for DNAH1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAH1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH1 |
Orthologs
for DNAH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DNAH1 gene from 3/18 species (see all 18) About this table
ENSEMBL Gene Tree for DNAH1 (if available)
TreeFam Gene Tree for DNAH1 (if available) |
Paralogs
for DNAH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DNAH1 gene
- DNAH52 DNAH22 DNAH82 DYNC1H12 DYNC2H12 DNAH92 DNAH32 DNAH112
- DNAH62 DNAH72 DNAH102 DNAH172
17 SIMAP similar genes for DNAH1 using alignment to 4 protein entries: DYH1_HUMAN (see all proteins):Dnahc11 Dnahc9 Dnahc3 Dnchc1 DNAH5 DNAH2
DNAH10 DNAH12 DNAH3 DNAH7 DNAH14 DNAH11
DNAH6 DNAH9 DNAH17 DYNC2H1 DNAH8
DNAH1 for paralogs About GeneDecksing
|
Genomic Variants
for DNAH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAH1 (52350335 - 52434513 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DNAH1
1 CNV: 4338 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAH1 |
|
Disorders
/ Diseases
for DNAH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAH1 for disorders About GeneDecksing
OMIM gene information: 603332
OMIM disorders: --
6  diseases for DNAH1: About MalaCardsciliary dyskinesia primary ciliary dyskinesia situs inversus bronchiectasis
huntington's disease immunodeficiency
2 diseases from the University of Copenhagen DISEASES database for DNAH1:Primary ciliary dyskinesia Situs inversus Export disorders for DNAH1 gene to outside databases
|
Publications
for DNAH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAH1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DNAH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. (PubMed id 9256245)1, 2, 3 Chapelin C....Amselem S. (1997)
- Multiple mouse chromosomal loci for dynein-based motility. (PubMed id 8812413)1, 2, 3 Vaughan K.T....Vallee R.B. (1996)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PubMed id 9373155)1, 2 Neesen J.... Schmid M. (1997)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- SNX4 in complex with clathrin and dynein: implication s for endosome movement. (PubMed id 19529763)1 SkAYnland S.S....Sandvig K. (2009)
- Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on Dynein motor function and late endosome positioning. (PubMed id 19286658)1 Lehmann M....Mouland A.J. (2009)
- Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. (PubMed id 18492703)1 Zuccarello D....Foresta C. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
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External Searches for DNAH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DNAH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DNAH1 gene
(According to HUGE)
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Specialized Databases showing DNAH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for DNAH1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DNAH1 gene:
Search GeneIP for patents involving DNAH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DNAH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAH1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAH1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAH1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAH1 | | OriGene 3'-UTR Clone for DNAH1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAH1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAH1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAH1 | | OriGene Custom Protein Services for DNAH1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAH1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAH1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAH1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAH1 |
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| | | | Search Tocris compounds for DNAH1 |
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 | | | DNAH1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAH1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DNAH1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DNAH1 |
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