Aliases for DNAAF4 Gene
External Ids for DNAAF4 Gene
Previous HGNC Symbols for DNAAF4 Gene
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for DNAAF4 Gene
DNAAF4 (Dynein Axonemal Assembly Factor 4) is a Protein Coding gene. Diseases associated with DNAAF4 include Primary Ciliary Dyskinesia25: Dnaaf4-Related Primary Ciliary Dyskinesia and Ciliary Dyskinesia, Primary, 25.
UniProtKB/Swiss-Prot for DNAAF4 Gene
Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility.