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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNA2 Gene

protein-coding   GIFtS: 55
GCID: GC10M070173

DNA Replication Helicase/Nuclease 2

(Previous names: DNA2 DNA replication helicase 2-like (yeast), DNA replication...)
(Previous symbol: DNA2L)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DNA Replication Helicase/Nuclease 21 2     DNA2 DNA Replication Helicase 2-Like (Yeast)1
DNA2L1 2 3 5     PEOA62
DNA Replication ATP-Dependent Helicase-Like Homolog2 3     DNA Replication ATP-Dependent Helicase/Nuclease DNA22
hDNA22 3     DNA Replication Helicase 2 Homolog2
KIAA00833 5     DNA2-Like Helicase2
DNA Replication Helicase 2 Homolog (Yeast)1     

External Ids:    HGNC: 29391   Entrez Gene: 17632   Ensembl: ENSG000001383467   OMIM: 6018105   UniProtKB: P515303   

Export aliases for DNA2 gene to outside databases

Previous GC identifers: GC10M069844 GC10M064173


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNA2 Gene:
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability
(Duxin et al., 2009 (PubMed 19487465)).(supplied by OMIM, Nov 2010)

GeneCards Summary for DNA2 Gene: 
DNA2 (DNA replication helicase/nuclease 2) is a protein-coding gene. Diseases associated with DNA2 include werner syndrome, and among its related super-pathways are Lagging Strand Synthesis and Synthesis of DNA. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and ATPase activity.

UniProtKB/Swiss-Prot: DNA2_HUMAN, P51530
Function: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki
fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are
coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too
short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand
break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is
prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments
processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3'
helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a
key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.
According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase
activity may promote the motion of DNA2 on the flap, helping the nuclease function

Gene Wiki entry for DNA2 (DNA2L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNA2 gene promoter:
         FOXF2   AML1a   IRF-1   Evi-1   AREB6   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DNA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3-q22.1   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q21.3-q22.1

DNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNA2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M070173:  view genomic region     (about GC identifiers)

Start:
70,173,821 bp from pter      End:
70,231,879 bp from pter
Size:
58,059 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNA2_HUMAN, P51530 (See protein sequence)
Recommended Name: DNA replication ATP-dependent helicase/nuclease DNA2  
Size: 1060 amino acids; 120415 Da
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Interacts with BLM and WDHD1
Subcellular location: Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial
(PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465)
Sequence caution: Sequence=AAH28188.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH63664.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA07647.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI17237.1; Type=Erroneous gene
model prediction; Sequence=CAI17238.1; Type=Erroneous gene model prediction;
Secondary accessions: Q2NKM1 Q5TC49 Q5TC50 Q6P455 Q6PI80 Q7Z6H9 Q8N346
Alternative splicing: 4 isoforms:  P51530-1   P51530-2   P51530-3   P51530-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNA2: NX_P51530

Explore proteomics data for DNA2 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated by EP300, leading to stimulate the 5'-3' endonuclease, the 5'-3' helicase and DNA-dependent ATPase
    activities, possibly by increasing DNA substrate affinity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51530

  • DNA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNA2 Protein Expression
    REFSEQ proteins: NP_001073918.2  
    ENSEMBL proteins: 
     ENSP00000450393   ENSP00000351185   ENSP00000389713   ENSP00000450014   ENSP00000382133  
     ENSP00000382132  
    Reactome Protein details: P51530
    Human Recombinant Protein Products for DNA2: 
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    OriGene Protein Over-expression Lysate for DNA2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DNA2
    GenScript Custom Purified and Recombinant Proteins Services for DNA2
    Novus Biologicals DNA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19487465
    GO:0005654nucleoplasm TAS--
    GO:0005760colocalizes with gamma DNA polymerase complex IDA18995831
    GO:0042645mitochondrial nucleoid IDA19487465

    DNA2 for ontologies           About GeneDecksing



    DNA2 Antibody Products: 
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    ThermoFisher Antibody for DNA2
    LSBio Antibodies in human, mouse, rat for DNA2 

    Assay Products for DNA2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR026851 Dna2
     IPR027417 P-loop_NTPase
     IPR014808 DNA_replication_fac_Dna2_N

    Graphical View of Domain Structure for InterPro Entry P51530

    ProtoNet protein and cluster: P51530

    UniProtKB/Swiss-Prot: DNA2_HUMAN, P51530
    Similarity: Belongs to the DNA2/NAM7 helicase family


    DNA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNA2_HUMAN, P51530
    Function: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki
    fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are
    coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too
    short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand
    break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is
    prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments
    processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3'
    helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a
    key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.
    According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase
    activity may promote the motion of DNA2 on the flap, helping the nuclease function
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA--
    GO:0003678NOT DNA helicase activity IDA16595799
    GO:0004386helicase activity TAS18995831
    GO:0004518nuclease activity IDA--
    GO:0005515protein binding IPI--
         
    DNA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DNA2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNA2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNA2
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DNA2 (see all 19):
    hsa-miR-607 hsa-let-7d hsa-let-7c hsa-miR-1297 hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-320e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNA2

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of DNA2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DNA2 (see all 8)
    OriGene ORF clones in mouse, rat for DNA2
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    GenScript: all cDNA clones in your preferred vector: DNA2 (NM_001080449)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNA2
    Sirion Biotech Customized lentivirus for stable overexpression of DNA2 
                         Customized lentivirus expression plasmids for stable overexpression of DNA2 

    Cell Line
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    Search LifeMap BioReagents cell lines for DNA2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNA2 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Lagging Strand Synthesis
    Processive synthesis on the lagging strand0.93
    Removal of the Flap Intermediate from the C-strand0.91
    Removal of the Flap Intermediate0.93
    Processive synthesis on the C-strand of the telomere0.91
    Telomere C-strand (Lagging Strand) Synthesis0.92
    DNA strand elongation0.65
    Extension of Telomeres0.92
    DNA replication0.63
    2CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.79
    DNA Replication0.78
    S Phase0.79
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Packaging Of Telomere Ends
    Telomere Maintenance0.56
    5Meiotic Synapsis
    Chromosome Maintenance0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/15        Reactome Pathways for DNA2 (see all 15)
        Extension of Telomeres
    Processive synthesis on the lagging strand
    Telomere Maintenance
    Processive synthesis on the C-strand of the telomere
    Synthesis of DNA


    1         Kegg Pathway  (Kegg details for DNA2):
        DNA replication


    DNA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for DNA2 (P515303 ENSP000003821334) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEN1P397483, ENSP000003054804I2D: score=3 STRING: ENSP00000305480
    LIG1P188583, ENSP000002632744I2D: score=1 STRING: ENSP00000263274
    MRE11AP499593, ENSP000003258634I2D: score=1 STRING: ENSP00000325863
    RAD51Q066093, ENSP000002678684I2D: score=1 STRING: ENSP00000267868
    RNASEH2AO757923, ENSP000002214864I2D: score=1 STRING: ENSP00000221486
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076DNA replication checkpoint IMP--
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0000729DNA double-strand break processing IDA--

    DNA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNA2

    Search CenterWatch for drugs/clinical trials and news about DNA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNA2 gene: 
    NM_001080449.2  

    Unigene Cluster for DNA2:

    DNA replication helicase 2 homolog (yeast)
    Hs.532446  [show with all ESTs]
    Unigene Representative Sequence: NM_001080449
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551118(uc001jog.2) ENST00000358410 ENST00000440722(uc021prv.1)
    ENST00000550545 ENST00000478029 ENST00000550357 ENST00000399180(uc021prt.1 uc021pru.1)
    ENST00000399179
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNA2
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DNA2 (see all 19):
    hsa-miR-607 hsa-let-7d hsa-let-7c hsa-miR-1297 hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-320e
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    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNA2
    Clone
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    OriGene ORF clones in mouse, rat for DNA2
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNA2
    Sirion Biotech Customized lentivirus for stable overexpression of DNA2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNA2

    Additional mRNA sequence: 

    AK307939.1 AK308333.1 AK308358.1 BC017003.1 BC028188.1 BC041115.2 BC053574.1 BC063664.1 
    BC073945.1 D42046.1 NR_102264.1 

    8 DOTS entries:

    DT.112866  DT.452500  DT.100720400  DT.99933420  DT.100737990  DT.86851248  DT.100716362  DT.91758755 

    24/58 AceView cDNA sequences (see all 58):

    BC041115 D42046 BC063664 AA282472 BC017003 AA767191 BE349079 AA282473 
    AA745243 CR606021 BC053574 AA282895 BX329314 AA284382 BC073945 BC028188 
    AA974495 AI248069 AA282803 AW181911 AW628305 BX390869 BG501340 BG106738 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNA2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
    SP1:                                -                       -               
    SP2:                                -           -           -               
    SP3:                                                                        


    ECgene alternative splicing isoforms for DNA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNA2 expression in normal human tissues (normalized intensities)      DNA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTTTTTA
    DNA2 Expression
    About this image


    DNA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             cmps   
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See DNA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNA2

    SOURCE GeneReport for Unigene cluster: Hs.532446
        SABiosciences Custom PCR Arrays for DNA2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNA2 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dna21 , 5 DNA replication helicase 2 homolog (yeast)1, 5 78.21(n)1
    80(a)1
      10 (32.51 cM)5
    3277621  NM_177372.31  NP_796346.21 
     629470265 
    chicken
    (Gallus gallus)
    Aves DNA21 DNA replication helicase 2 homolog (yeast) 69.59(n)
    67.24(a)
      423688  NM_001006497.1  NP_001006497.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNA26
    DNA replication helicase 2 homolog (yeast)
    64(a)
    1 ↔ 1
    GL343215.1(1559343-1595449)
    African clawed frog
    (Xenopus laevis)
    Amphibia dna2-A2 helicase 73.11(n)    AF474372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174692 Transcribed sequence with moderate similarity to protein more 72.91(n)    BM957338.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29901 CG2990 44.83(n)
    35.89(a)
      31934  NM_167214.1  NP_727386.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dna-21 Protein DNA-2 43.55(n)
    34.18(a)
      174809  NM_064115.2  NP_496516.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DNA2(YHR164C)4
    DNA21
    Tripartite DNA replication factor with single-stranded more4
    Dna2p1
    46.16(n)1
    37.08(a)1
      8(429178-424610)4
    8565691, 4  NP_012034.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb24111 DNA replication ATP-dependent helicase Dna2 47.05(n)
    36.69(a)
      837406  NM_001198014.1  NP_001184943.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05882001 hypothetical protein 47.63(n)
    37.96(a)
      4336807  NM_001060229.2  NP_001053694.2 


    ENSEMBL Gene Tree for DNA2 (if available)
    TreeFam Gene Tree for DNA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1430 SNPs in DNA2 are shown (see all 1430)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807137371,2
    --70173345(+) AACCCC/GTCTCC 2 -- int10--------
    rs1839035761,2
    --70173405(+) ATGCTA/GCTTGG 2 -- int10--------
    rs1418412501,2
    --70173466(+) TGCGGC/TCGGGC 2 -- int10--------
    rs618550861,2
    --70173472(+) CGGGCA/GCGGTG 2 -- int10--------
    rs1893807701,2
    C--70173537(+) TCAGGA/CGATGG 2 -- int10--------
    rs1823243701,2
    --70173599(+) AAAAAA/CATTAG 2 -- int10--------
    rs1869262621,2
    C--70173611(+) TAGGCA/C/GTGGTG 2 -- int10--------
    rs127818641,2
    C,F--70173619(+) GTGGCG/AGGCAC 2 -- int12Minor allele frequency- A:0.50NA 4
    rs1914121791,2
    C--70173641(+) GCTACG/TCGGGA 2 -- int10--------
    rs340727151,2
    F--70173642(+) CTACTC/TGGGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for DNA2 (70173821 - 70231879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DNA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674968CNV Deletion23128226
    esv2675728CNV Deletion23128226
    nsv895691CNV Loss21882294
    nsv895692CNV Loss21882294


    Human Gene Mutation Database (HGMD): DNA2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DNA2
    DNA2.0 Custom Variant and Variant Library Synthesis for DNA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601810    OMIM disorders: --

    2 diseases for DNA2:    About MalaCards
    werner syndrome    

    1 disease from the University of Copenhagen DISEASES database for DNA2:
    Werner syndrome

    DNA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNA2
    Human Genome Epidemiology (HuGE) Navigator: DNA2 (1 document)

    Export disorders for DNA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNA2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with DNA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in DNA2 link progressive myopathy to mitocho ndrial DNA instability. (PubMed id 23352259)1, 3 Ronchi D....Comi G.P. (2013)
    2. Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. (PubMed id 22570407)1, 2 Gloor J.W.... Bambara R.A. (2012)
    3. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. (PubMed id 22570476)1, 2 Duxin J.P.... Stewart S.A. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Acetylation of Dna2 endonuclease/helicase and flap en donuclease 1 by p300 promotes DNA stability by creating long flap intermediates . (PubMed id 20019387)1, 2 Balakrishnan L....Bambara R.A. (2010)
    6. Human Dna2 is a nuclear and mitochondrial DNA mainten ance protein. (PubMed id 19487465)1, 2 Duxin J.P....Stewart S.A. (2009)
    7. Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. (PubMed id 18995831)1, 2 Zheng L....Shen B. (2008)
    8. Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation. (PubMed id 17032657)1, 3 Masuda-Sasa T....Campbell J.L. (2006)
    9. Biochemical analysis of human Dna2. (PubMed id 16595800)1, 2 Masuda-Sasa T....Campbell J.L. (2006)
    10. Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. (PubMed id 16595799)1, 2 Kim J.H....Seo Y.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1763 HGNC: 2939 AceView: DNA2L Ensembl:ENSG00000138346 euGenes: HUgn1763
    ECgene: DNA2 Kegg: 1763 H-InvDB: DNA2

    (According to HUGE)
    About This Section
    HUGE: KIAA0083

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNA2 gene:
    Search GeneIP for patents involving DNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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