DNA2 Gene
protein-coding GIFtS: 53
GCID: GC10M070173
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DNA replication helicase 2 homolog (yeast)(Previous name: DNA2 DNA replication helicase 2-like (yeast) )
(Previous symbol: DNA2L)
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Aliases
for DNA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DNA Replication Helicase 2 Homolog (Yeast)1 2 | | HDNA21 | | DNA2L1 2 3 5 | | DNA2 DNA Replication Helicase 2-Like (Yeast)1 | | KIAA00831 3 5 | | DNA Replication ATP-Dependent Helicase/Nuclease DNA22 | | DNA Replication ATP-Dependent Helicase-Like Homolog2 3 | | DNA2-Like Helicase2 |
Export aliases for DNA2 gene to outside databasesPrevious GC identifers: GC10M069844 GC10M064173 |
Summaries
for DNA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DNA2:
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin etal., 2009 (PubMed 19487465)).(supplied by OMIM, Nov 2010)
UniProtKB/Swiss-Prot: DNA2_HUMAN, P51530Function: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazakifragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated byreplication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPAand becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair:recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence ofRPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses differentenzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonucleaseactivities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragmentsprocessing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, thehelicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2on the flap, helping the nuclease function
Gene Wiki entry for DNA2 (DNA2L)
|
Genomic Views
for DNA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNA2 gene promoter:
FOXF2 AML1a IRF-1 Evi-1 AREB6 PPAR-gamma1 FOXJ2 (long isoform) PPAR-gamma2 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q21.3-q22.1 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q21.3-q22.1DNA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M070173: view genomic region
(about GC identifiers)
Start:
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70,173,821 bp from pter |
End:
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70,231,879 bp from pter |
Size:
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58,059 bases |
Orientation:
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minus strand |
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Proteins
for DNA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNA2_HUMAN, P51530 (See
protein sequence)Recommended Name: DNA replication ATP-dependent helicase/nuclease DNA2 Size: 1060 amino acids; 120415 Da
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Interacts with BLM and WDHD1
Subcellular location: Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial(PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465)
Sequence caution: Sequence=AAH28188.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH63664.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA07647.1;Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI17237.1; Type=Erroneous gene modelprediction; Sequence=CAI17238.1; Type=Erroneous gene model prediction;
Secondary accessions: Q2NKM1 Q5TC49 Q5TC50 Q6P455 Q6PI80 Q7Z6H9 Q8N346Alternative splicing: 4 isoforms: P51530-1 P51530-2 P51530-3 P51530-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DNA2: NX_P51530
Post-translational modifications:
Acetylated by EP300, leading to stimulate the 5'-3' endonuclease, the 5'-3' helicase and DNA-dependent ATPaseactivities, possibly by increasing DNA substrate affinity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51530
DNA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073918.2
ENSEMBL proteins: ENSP00000450393 ENSP00000351185 ENSP00000450033 ENSP00000389713 ENSP00000450014 ENSP00000382133 ENSP00000382132 Reactome Protein details: P51530
Human Recombinant Protein Products for DNA2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DNA2 for ontologies About GeneDecksing
DNA2 Antibody Products:
Assay Products for DNA2: |
Protein
Domains /
Families
for DNA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNA2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51530ProtoNet protein and cluster: P51530 UniProtKB/Swiss-Prot: DNA2_HUMAN, P51530Similarity: Belongs to the DNA2/NAM7 helicase family |
Function
for DNA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DNA2_HUMAN, P51530Function: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazakifragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated byreplication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPAand becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair:recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence ofRPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses differentenzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonucleaseactivities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragmentsprocessing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, thehelicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2on the flap, helping the nuclease functionCatalytic activity: ATP + H(2)O = ADP + phosphate Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table
DNA2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DNA2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNA2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNA2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNA2 (NM_001080449) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNA2 |
|
Pathways & Interactions
for DNA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lagging Strand Synthesis | | | 2 | Ubiquitinated Orc1 is degraded by the proteasome | | | 3 | Cell Cycle | | | 4 | Meiotic Synapsis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/15 
Reactome Pathways for DNA2 (see all 15)
1 
Kegg Pathway (Kegg details for DNA2):
DNA2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for DNA2 (P515303 ENSP000003821334) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000076 | DNA replication checkpoint |
IMP | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0000722 | telomere maintenance via recombination |
TAS | -- | | GO:0000723 | telomere maintenance |
TAS | -- |
DNA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNA2
Search CenterWatch for drugs/clinical trials and news about DNA2
|
Transcripts
for DNA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNA2 gene: NM_001080449.2 Unigene Cluster for DNA2: DNA replication helicase 2 homolog (yeast) Hs.532446 [show with all ESTs]Unigene Representative Sequence: NM_0010804499 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000551118(uc001jog.2) ENST00000358410 ENST00000549829(uc001joh.2)
ENST00000440722(uc021prv.1) ENST00000550545 ENST00000478029 ENST00000550357
ENST00000399180(uc021prt.1 uc021pru.1) ENST00000399179
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNA2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNA2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNA2 (NM_001080449) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNA2 |
Additional cDNA sequence: AK307939.1 AK308333.1 AK308358.1 BC017003.1 BC028188.1 BC041115.2 BC053574.1 BC063664.1 BC073945.1 D42046.1 8 DOTS entries: DT.112866 DT.452500 DT.100720400 DT.99933420 DT.100737990 DT.86851248 DT.100716362 DT.91758755 24/58 AceView cDNA sequences (see all 58): BC041115 AA767191 D42046 AA282895 AA282472 AA745243 BC063664 AA284382 BC073945 BC017003 BC053574 AA282473 BX329314 CR606021 BE349079 AA292702 CD644575 AI186294 BX390869 BG106738 BC028188 BM745495 AA830575 BI869219
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DNA2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNA2
|
Expression
for DNA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTTTTTA
About this image
See DNA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNA2
SOURCE GeneReport for Unigene cluster: Hs.532446
SABiosciences Custom PCR Arrays for DNA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNA2 |
Orthologs
for DNA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DNA2 gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for DNA2 (if available)
TreeFam Gene Tree for DNA2 (if available) |
Paralogs
for DNA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNA2 (70173821 - 70231879 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNA2 |
|
Disorders
/ Diseases
for DNA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNA2 for disorders About GeneDecksing
OMIM gene information: 601810
OMIM disorders: --
3  diseases for DNA2: About MalaCardswerner syndrome hermaphroditism malaria
1 disease from the University of Copenhagen DISEASES database for DNA2:Werner syndrome Human Genome Epidemiology (HuGE) Navigator: DNA2 (1 document)
Export disorders for DNA2 gene to outside databases
|
Publications
for DNA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNA2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with DNA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. (PubMed id 22570407)1, 2 Gloor J.W.... Bambara R.A. (2012)
- Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. (PubMed id 22570476)1, 2 Duxin J.P.... Stewart S.A. (2012)
- Acetylation of Dna2 endonuclease/helicase and flap en donuclease 1 by p300 promotes DNA stability by creating long flap intermediates . (PubMed id 20019387)1, 2 Balakrishnan L....Bambara R.A. (2010)
- Human Dna2 is a nuclear and mitochondrial DNA mainten ance protein. (PubMed id 19487465)1, 2 Duxin J.P....Stewart S.A. (2009)
- Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. (PubMed id 18995831)1, 2 Zheng L....Shen B. (2008)
- Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation. (PubMed id 17032657)1, 3 Masuda-Sasa T....Campbell J.L. (2006)
- Biochemical analysis of human Dna2. (PubMed id 16595800)1, 2 Masuda-Sasa T....Campbell J.L. (2006)
- Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. (PubMed id 16595799)1, 2 Kim J.H....Seo Y.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
|
External Searches for DNA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNA2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DNA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNA2 gene:
Search GeneIP for patents involving DNA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNA2 | | | OriGene Protein Over-expression Lysate for DNA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for DNA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNA2 | | OriGene Custom Protein Services for DNA2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNA2 |
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 |  |  |  | |
| | | | Search Tocris compounds for DNA2 |
| |  |  |  |  | | | | |
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 | | | DNA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNA2 |
|  |  |  |  | | | | ThermoFisher Antibody for DNA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNA2 |
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