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DMXL2 Gene

protein-coding   GIFtS: 51
GCID: GC15M051739

Dmx-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dmx-Like 21 2     DmX-Like Protein 22
RC32 5     rabconnectin-32
KIAA08563 5     Rabconnectin-33
Rabconnectin 31     

External Ids:    HGNC: 29381   Entrez Gene: 233122   Ensembl: ENSG000001040937   OMIM: 6121865   UniProtKB: Q8TDJ63   

Export aliases for DMXL2 gene to outside databases

Previous GC identifers: GC00U990082 GC15M049529 GC15M028569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DMXL2 Gene:
This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including
participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch
signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding
a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for DMXL2 Gene:
DMXL2 (Dmx-like 2) is a protein-coding gene. Diseases associated with DMXL2 include gynecomastia, and myocardial infarction. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is DMXL1.

UniProtKB/Swiss-Prot: DMXL2_HUMAN, Q8TDJ6
Function: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMXL2 gene promoter:
         STAT1   Brachyury   SREBP-1c   RelA   Nkx5-1   NF-kappaB   SREBP-1b   FOXC1   SREBP-1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DMXL2 promoter sequence
   Search Chromatin IP Primers for DMXL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMXL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

DMXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMXL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M051739:  view genomic region     (about GC identifiers)

Start:
51,739,908 bp from pter      End:
51,915,030 bp from pter
Size:
175,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DMXL2_HUMAN, Q8TDJ6 (See protein sequence)
Recommended Name: DmX-like protein 2  
Size: 3036 amino acids; 339641 Da
Subunit: Interacts with MADD and RAB3GAP
Secondary accessions: B2RTR3 B7ZMH3 F5GWF1 O94938
Alternative splicing: 3 isoforms:  Q8TDJ6-1   Q8TDJ6-2   Q8TDJ6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DMXL2: NX_Q8TDJ6

Explore proteomics data for DMXL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DMXL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001167587.1  NP_001167588.1  NP_056078.2  

    ENSEMBL proteins: 
     ENSP00000251076   ENSP00000453267   ENSP00000441858   ENSP00000400855   ENSP00000453570  
     ENSP00000453454  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR022033 Rav1p_C
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TDJ6

    ProtoNet protein and cluster: Q8TDJ6

    UniProtKB/Swiss-Prot: DMXL2_HUMAN, Q8TDJ6
    Similarity: Contains 16 WD repeats


    DMXL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMXL2_HUMAN, Q8TDJ6
    Function: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017137Rab GTPase binding IDA11809763
         
    DMXL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DMXL2:
     Decreased melanin production 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dmxl2):
     mortality/aging 

    DMXL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMXL2
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    miRNA
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    miRTarBase miRNAs that target DMXL2:
    hsa-mir-19b-3p (MIRT031117), hsa-mir-26b-5p (MIRT028846)

    Block miRNA regulation of human, mouse, rat DMXL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMXL2 (see all 49):
    hsa-miR-579 hsa-miR-4291 hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-548k hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidDMXL2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMXL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DMXL2_HUMAN, Q8TDJ6: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane
    protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0008021synaptic vesicle IDA11809763
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    DMXL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMXL2
    Interactions:

        Search GeneGlobe Interaction Network for DMXL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DMXL2 (Q8TDJ63 ENSP000002510764) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB3AP203363, ENSP000002222564I2D: score=1 STRING: ENSP00000222256
    WDR7Q9Y4E63, ENSP000002544424I2D: score=1 STRING: ENSP00000254442
    RAB3GAP1Q150423, ENSP000002641584I2D: score=1 STRING: ENSP00000264158
    SKP1ENSP000002314874STRING: ENSP00000231487
    ATP6V1AENSP000002733984STRING: ENSP00000273398
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMXL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DMXL2 gene (3 alternative transcripts): 
    NM_001174116.1  NM_001174117.1  NM_015263.3  

    Unigene Cluster for DMXL2:

    Dmx-like 2
    Hs.511386  [show with all ESTs]
    Unigene Representative Sequence: NM_001174116
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251076(uc002abc.3 uc002abd.3 uc002abf.3 uc010ufy.2 uc010bfa.3)
    ENST00000560891 ENST00000543779 ENST00000559769 ENST00000449909 ENST00000559059
    ENST00000559868 ENST00000559062 ENST00000558124 ENST00000560211 ENST00000559498
    ENST00000561079 ENST00000560421 ENST00000558507(uc002abg.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DMXL2 (see all 49):
    hsa-miR-579 hsa-miR-4291 hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-548k hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidDMXL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DMXL2
    Predesigned siRNA for gene silencing in human, mouse, rat DMXL2
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    GenScript: all cDNA clones in your preferred vector (see all 3): DMXL2 (NM_015263)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMXL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMXL2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMXL2
      QuantiTect SYBR Green Assays in human, mouse, rat DMXL2
      QuantiFast Probe-based Assays in human, mouse, rat DMXL2

    Additional mRNA sequence: 

    AB020663.2 AF389880.1 AK123284.1 AK124842.1 BC016032.1 BC022050.1 BC035883.1 BC140781.1 
    BC144539.1 

    14 DOTS entries:

    DT.416108  DT.100754732  DT.99974689  DT.91952731  DT.101955509  DT.121030958  DT.70102376  DT.101964613 
    DT.101965783  DT.75190943  DT.95253083  DT.101981965  DT.91864457  DT.91988819 

    Selected AceView cDNA sequences (see all 154):

    BE467083 BU631117 F12505 CF552872 BQ027892 CD677041 BG696308 BM792393 
    AA490811 F01904 C14891 AL537218 F02876 AI452868 AI198632 AW193076 
    BQ440524 AA339493 AW662081 CD105481 BM801896 AA629921 AW025952 BU616940 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DMXL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b · 44c
    SP1:                                                                    -     -                                                                           
    SP2:                                                                    -     -                                                                           
    SP3:                                                                          -                                                                           
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for DMXL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DMXL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGAGAA
    DMXL2 Expression
    About this image


    DMXL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    DMXL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMXL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511386
        Custom PCR Arrays for DMXL2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMXL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DMXL2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmxl21 , 5 Dmx-like 21, 5 88.47(n)1
    93.1(a)1
      9 (29.58 cM)5
    2353801  NM_172771.21  NP_766359.21 
     543651585 
    chicken
    (Gallus gallus)
    Aves DMXL21 Dmx-like 2 79.46(n)
    85.16(a)
      415594  XM_003641847.2  XP_003641895.1 
    lizard
    (Anolis carolinensis)
    Reptilia DMXL26
    Dmx-like 2
    80(a)
    1 ↔ 1
    GL343330.1(383966-455259)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dmxl21 Dmx-like 2 73.33(n)
    77.83(a)
      100145665  NM_001127055.2  NP_001120527.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.124672 Transcribed sequence with weak similarity to protein more 72.24(n)    57079903 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rbcn-3A1 Rabconnectin-3A 48.55(n)
    44.69(a)
      31557  NM_132074.2  NP_572302.2 
    worm
    (Caenorhabditis elegans)
    Secernentea rbc-11 rbc-1 47.14(n)
    36.27(a)
      181558  NM_001270317.1  NP_001257246.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAV16
    Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p),...
    23(a)
    1 → many
    X(492378-496451) YJR033C


    ENSEMBL Gene Tree for DMXL2 (if available)
    TreeFam Gene Tree for DMXL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DMXL2 gene
    DMXL12  
    1 SIMAP similar gene for DMXL2 using alignment to 6 protein entries:     DMXL2_HUMAN (see all proteins):
    DMXL1

    DMXL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DMXL2 (see all 3536)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760513811,2
    C--28575673(+) CACTC-/TGAAATA 3 -- int11Minor allele frequency- TG:0.00CSA 2
    rs129019901,2
    C--28641898(+) TCTTGT/Gttttt 3 -- int1 trp31Minor allele frequency- G:0.00NA 2
    rs771423691,2
    C,F--31806142(+) AAAGCT/CCCTTT 3 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1381664331,2
    --31806156(+) TCAGTC/TTTGCT 3 -- ds50010--------
    rs1856426221,2
    --31806257(+) GCAAAC/TAGCCA 3 -- ds50010--------
    rs71642651,2
    C,F,A,H--31806380(+) TGTGCT/CTTCTC 3 -- ds500127Minor allele frequency- C:0.32NA NS EA WA 2906
    rs1891995871,2
    --31806399(+) TCTCCA/GCTGTA 3 -- ds50010--------
    rs733995151,2
    C,F--31806578(+) ATTTAC/TTTTTC 3 -- ut311Minor allele frequency- T:0.50WA 2
    rs1501428831,2
    C--31806592(+) TACATA/GTATAT 3 -- ut310--------
    rs1166524331,2
    C,F--31806663(+) TTACCA/GCACAG 3 -- ut311Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for DMXL2 (51739908 - 51915030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DMXL2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749689CNV Deletion23290073
    esv2671192CNV Deletion23128226
    esv3699CNV Deletion18987735
    esv272387CNV Insertion20981092
    nsv1535CNV Insertion18451855
    esv270281CNV Insertion20981092
    nsv904218CNV Loss21882294
    nsv904219CNV Loss21882294
    nsv457139CNV Loss19166990
    nsv457138CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612186    OMIM disorders: --

    4 diseases for DMXL2:    
    About MalaCards
    gynecomastia    myocardial infarction    asthma    malaria

    1 disease from the University of Copenhagen DISEASES database for DMXL2:
    Gynecomastia

    DMXL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DMXL2
    Human Genome Epidemiology (HuGE) Navigator: DMXL2 (2 documents)

    Export disorders for DMXL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DMXL2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DMXL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family. (PubMed id 11809763)1, 2, 9 Nagano F.... Takai Y. (J. Biol. Chem. 2002)
    2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    7. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)- dependent exocytosis of neurotransmitter. (PubMed id 12786944)1, 9 Kawabe H.... Takai Y. (Genes Cells 2003)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23312 HGNC: 2938 AceView: RC3 Ensembl:ENSG00000104093 euGenes: HUgn23312
    ECgene: DMXL2 H-InvDB: DMXL2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0856

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DMXL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DMXL2 gene:
    Search GeneIP for patents involving DMXL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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