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Aliases for DMXL1 Gene

Aliases for DMXL1 Gene

  • Dmx-Like 1 2 3
  • X-Like 1 Protein 4
  • XL1 4

External Ids for DMXL1 Gene

Previous GeneCards Identifiers for DMXL1 Gene

  • GC05P118107
  • GC05P118805
  • GC05P118437
  • GC05P118483
  • GC05P118435
  • GC05P113594

Summaries for DMXL1 Gene

Entrez Gene Summary for DMXL1 Gene

  • The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for DMXL1 Gene

DMXL1 (Dmx-Like 1) is a Protein Coding gene. An important paralog of this gene is DMXL2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMXL1 Gene

Genomics for DMXL1 Gene

Regulatory Elements for DMXL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DMXL1 Gene

Start:
119,037,772 bp from pter
End:
119,249,138 bp from pter
Size:
211,367 bases
Orientation:
Plus strand

Genomic View for DMXL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMXL1 Gene

Proteins for DMXL1 Gene

  • Protein details for DMXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y485-DMXL1_HUMAN
    Recommended name:
    DmX-like protein 1
    Protein Accession:
    Q9Y485
    Secondary Accessions:

    Protein attributes for DMXL1 Gene

    Size:
    3027 amino acids
    Molecular mass:
    337839 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMXL1 Gene

Proteomics data for DMXL1 Gene at MOPED

Post-translational modifications for DMXL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMXL1 Gene

No data available for DME Specific Peptides for DMXL1 Gene

Domains for DMXL1 Gene

Gene Families for DMXL1 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for DMXL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y485

UniProtKB/Swiss-Prot:

DMXL1_HUMAN :
  • Q9Y485
Similarity:
  • Contains 16 WD repeats.
genes like me logo Genes that share domains with DMXL1: view

Function for DMXL1 Gene

Gene Ontology (GO) - Molecular Function for DMXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DMXL1: view

Phenotypes for DMXL1 Gene

GenomeRNAi human phenotypes for DMXL1:
genes like me logo Genes that share phenotypes with DMXL1: view

Animal Model Products

miRNA for DMXL1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMXL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DMXL1 Gene

Localization for DMXL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMXL1 Gene COMPARTMENTS Subcellular localization image for DMXL1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DMXL1 Gene

Pathways for DMXL1 Gene

SuperPathways for DMXL1 Gene

No Data Available

Interacting Proteins for DMXL1 Gene

Gene Ontology (GO) - Biological Process for DMXL1 Gene

None

No data available for Pathways by source for DMXL1 Gene

Transcripts for DMXL1 Gene

Unigene Clusters for DMXL1 Gene

Dmx-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMXL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMXL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for DMXL1 Gene

GeneLoc Exon Structure for
DMXL1
ECgene alternative splicing isoforms for
DMXL1

Expression for DMXL1 Gene

mRNA expression in normal human tissues for DMXL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DMXL1 Gene

This gene is overexpressed in Cervix (12.8), Adrenal (8.0), Serum (7.9), and Blymphocyte (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DMXL1 Gene

SOURCE GeneReport for Unigene cluster for DMXL1 Gene Hs.181042

mRNA Expression by UniProt/SwissProt for DMXL1 Gene

Q9Y485-DMXL1_HUMAN
Tissue specificity: Expressed in bone, breast, eye, foreskin, heart, parathyroid, small intestine, testis, tonsils, placenta and uterus.
genes like me logo Genes that share expressions with DMXL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for DMXL1 Gene

Orthologs for DMXL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DMXL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC534524 35
  • 92.46 (n)
  • 93.25 (a)
DMXL1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMXL1 35
  • 92.49 (n)
  • 94.09 (a)
DMXL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmxl1 35
  • 89.46 (n)
  • 90.07 (a)
Dmxl1 16
Dmxl1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DMXL1 35
  • 99.61 (n)
  • 99.6 (a)
DMXL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmxl1 35
  • 89.78 (n)
  • 91.06 (a)
oppossum
(Monodelphis domestica)
Mammalia DMXL1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMXL1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DMXL1 35
  • 76.71 (n)
  • 78.41 (a)
DMXL1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMXL1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmxl1 35
  • 71.93 (n)
  • 74.31 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11740 35
zebrafish
(Danio rerio)
Actinopterygii LOC100333625 35
  • 59.12 (n)
  • 62.53 (a)
DMXL1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rbcn-3A 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rbc-1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAV1 36
  • 23 (a)
OneToMany
RAV1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for DMXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMXL1 Gene

ENSEMBL:
Gene Tree for DMXL1 (if available)
TreeFam:
Gene Tree for DMXL1 (if available)

Paralogs for DMXL1 Gene

Paralogs for DMXL1 Gene

Selected SIMAP similar genes for DMXL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DMXL1: view

Variants for DMXL1 Gene

Sequence variations from dbSNP and Humsavar for DMXL1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs921218 -- 119,071,886(-) TTTAA(A/G)AATCC intron-variant
rs921219 -- 119,071,675(-) GACGC(C/G)AGGGC intron-variant
rs971239 -- 119,230,342(+) acatt(G/T)gggtc intron-variant
rs1136729 -- 119,247,495(+) GTTTT(G/T)TTTTT utr-variant-3-prime
rs1136730 -- 119,247,498(+) TTTTT(A/C/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DMXL1 Gene

Variant ID Type Subtype PubMed ID
nsv882774 CNV Gain 21882294
nsv511113 CNV Complex 20534489
nsv4973 CNV Insertion 18451855
nsv509083 CNV Insertion 20534489
nsv275 CNV Insertion 15895083
esv2670990 CNV Deletion 23128226
dgv1846e1 CNV Complex 17122850
esv2730670 CNV Deletion 23290073

Relevant External Links for DMXL1 Gene

HapMap Linkage Disequilibrium report
DMXL1
Human Gene Mutation Database (HGMD)
DMXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMXL1 Gene

Disorders for DMXL1 Gene

Relevant External Links for DMXL1

Genetic Association Database (GAD)
DMXL1
Human Genome Epidemiology (HuGE) Navigator
DMXL1

No disorders were found for DMXL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DMXL1 Gene

Publications for DMXL1 Gene

  1. Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein. (PMID: 10708522) Kraemer C. … Schmidt E.R. (Genomics 2000) 2 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Scanning the human proteome for calmodulin-binding proteins. (PMID: 15840729) Shen X. … Liu R. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3
  5. Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. (PMID: 16865689) van den Boom J. … Reifenberger G. (Int. J. Cancer 2006) 3

Products for DMXL1 Gene

Sources for DMXL1 Gene

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