DMXL1 Gene
protein-coding GIFtS: 48
GCID: GC05P118435
|
|
Dmx-like 1
| |
Aliases
for DMXL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dmx-Like 11 2 | | X-Like 1 Protein2 3 | | DmX-Like Protein 12 | | XL13 |
Export aliases for DMXL1 gene to outside databasesPrevious GC identifers: GC05P118107 GC05P118805 GC05P118437 GC05P118483 GC05P113594 |
Summaries
for DMXL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DMXL1:
The protein encoded by this gene is a member of a superfamily of WD repeat proteins. The function of this protein isnot yet determined; however, other related family members perform functions involved in regulatory processes.(provided by RefSeq, Jul 2008)
|
Genomic Views
for DMXL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DMXL1 gene promoter:
AML1a MAZR Tal-1 Pax-5 NRSF form 1 Nkx2-2 NRSF form 2 E47 C/EBPalpha PPAR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DMXL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMXL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q22 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q22DMXL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P118435: view genomic region
(about GC identifiers)
Start:
|
118,373,467 bp from pter |
End:
|
118,584,833 bp from pter |
Size:
|
211,367 bases |
Orientation:
|
plus strand |
|
Proteins
for DMXL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DMXL1_HUMAN, Q9Y485 (See
protein sequence)Recommended Name: DmX-like protein 1 Size: 3027 amino acids; 337839 Da
Developmental stage: Expressed in whole embryoExplore the universe of human proteins at neXtProt for DMXL1: NX_Q9Y485
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y485
DMXL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005500.4
ENSEMBL proteins: ENSP00000427692 ENSP00000309690 ENSP00000439479
Human Recombinant Protein Products:
DMXL1 Antibody Products:
Assay Products for DMXL1: |
Protein
Domains /
Families
for DMXL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DMXL1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y485ProtoNet protein and cluster: Q9Y485 UniProtKB/Swiss-Prot: DMXL1_HUMAN, Q9Y485Similarity: Contains 16 WD repeats |
Function
for DMXL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMXL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMXL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DMXL1 (NM_005509) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMXL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMXL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMXL1 |
1 GenomeRNAi human phenotype for DMXL1:
|
Pathways & Interactions
for DMXL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMXL1
3 Interacting proteins for DMXL1 (Q9Y4853) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DMXL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DMXL1
Search CenterWatch for drugs/clinical trials and news about DMXL1
|
Transcripts
for DMXL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DMXL1 gene: NM_005509.4 Unigene Cluster for DMXL1: Dmx-like 1 Hs.181042 [show with all ESTs]Unigene Representative Sequence: AB59314215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509902 ENST00000503802 ENST00000311085(uc003ksd.2 uc010jcl.1 uc021ycw.1)
ENST00000510924 ENST00000515335 ENST00000514151 ENST00000504031 ENST00000512281
ENST00000504497 ENST00000507552 ENST00000502516 ENST00000511622 ENST00000505312(uc010jcm.1)
ENST00000514595(uc003kse.1) ENST00000539542(uc003ksc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMXL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMXL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DMXL1 (NM_005509) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMXL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMXL1 |
Additional cDNA sequence: AB593142.1 AJ005821.1 AK126726.1 BC028004.1 BC144537.1 BC150616.1 BC171784.1 BX649064.1 9 DOTS entries: DT.316444 DT.99934417 DT.101975656 DT.92003361 DT.316445 DT.120819326 DT.92425697 DT.95306587 DT.99984668 24/139 AceView cDNA sequences (see all 139): AI091978 CD368443 AA748719 BI906248 AA330344 AW235114 CA389957 BU189806 AA730047 AA287662 AW008473 BC028004 AA761752 AA889128 BX473791 AA279184 BX090067 CA309379 AW192679 W03156 BP355058 AW300545 AA722458 BU621708
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DMXL1 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | · | 31c | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DMXL1
|
Expression
for DMXL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DMXL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DMXL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DMXL1
SOURCE GeneReport for Unigene cluster: Hs.181042
UniProtKB/Swiss-Prot: DMXL1_HUMAN, Q9Y485Tissue specificity: Expressed in bone, breast, eye, foreskin, heart, parathyroid, small intestine, testis, tonsils,placenta and uterus
SABiosciences Custom PCR Arrays for DMXL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DMXL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DMXL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMXL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMXL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMXL1 |
Orthologs
for DMXL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DMXL1 gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for DMXL1 (if available)
TreeFam Gene Tree for DMXL1 (if available) |
Paralogs
for DMXL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DMXL1 gene
- DMXL22
1 SIMAP similar gene for DMXL1 using alignment to 7 protein entries: DMXL1_HUMAN (see all proteins):DMXL2
DMXL1 for paralogs About GeneDecksing
|
Genomic Variants
for DMXL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DMXL1 (118373467 - 118584833 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for DMXL1
4 CNVs: 0591 36339 36338 2599
Human Gene Mutation Database (HGMD): DMXL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DMXL1 |
|
Disorders
/ Diseases
for DMXL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DMXL1 for disorders About GeneDecksing
OMIM gene information: 605671
OMIM disorders: --
1  disease for DMXL1: About MalaCardstonsillitis
Human Genome Epidemiology (HuGE) Navigator: DMXL1 (2 documents)
Export disorders for DMXL1 gene to outside databases
|
Publications
for DMXL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DMXL1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DMXL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein. (PubMed id 10708522)1, 2, 3, 9 Kraemer C.... Schmidt E.R. (2000)
- Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Scanning the human proteome for calmodulin-binding pr oteins. (PubMed id 15840729)1 Shen X....Liu R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for DMXL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DMXL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DMXL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DMXL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DMXL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DMXL1 gene:
Search GeneIP for patents involving DMXL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DMXL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DMXL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DMXL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DMXL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DMXL1 | | OriGene 3'-UTR Clone for DMXL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMXL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMXL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMXL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DMXL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMXL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DMXL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMXL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMXL1 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMXL1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMXL1 |
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