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DMWD Gene

protein-coding   GIFtS: 53
GCID: GC19M046286

Dystrophia Myotonica, WD Repeat Containing

(Previous name: dystrophia myotonica-containing WD repeat motif)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dystrophia Myotonica, WD Repeat Containing1 2     DMR-N92
Dystrophia Myotonica-Containing WD Repeat Motif Protein2 3     Dystrophia Myotonica WD Repeat-Containing Protein2
Protein 592 3     gene592
DMRN92 5     DM93
Dystrophia Myotonica-Containing WD Repeat Motif1     Protein DMR-N93
D19S593E2     

External Ids:    HGNC: 29361   Entrez Gene: 17622   Ensembl: ENSG000001858007   OMIM: 6098575   UniProtKB: Q090193   

Export aliases for DMWD gene to outside databases

Previous GC identifers: GC19M046917 GC19M046664 GC19M050962 GC19M050979 GC19M050978 GC19M042714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DMWD Gene:
DMWD (dystrophia myotonica, WD repeat containing) is a protein-coding gene. Diseases associated with DMWD include triple-a syndrome, and myotonic dystrophy type 1. An important paralog of this gene is WDR20.

UniProtKB/Swiss-Prot: DMWD_HUMAN, Q09019
Function: Could have a regulatory function in meiosis

Gene Wiki entry for DMWD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMWD gene promoter:
         CREB   AREB6   deltaCREB   CUTL1   Nkx2-5   NF-kappaB   NF-kappaB1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DMWD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMWD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

DMWD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMWD gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046286:  view genomic region     (about GC identifiers)

Start:
46,286,205 bp from pter      End:
46,296,060 bp from pter
Size:
9,856 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DMWD_HUMAN, Q09019 (See protein sequence)
Recommended Name: Dystrophia myotonica WD repeat-containing protein  
Size: 674 amino acids; 70438 Da
Miscellaneous: May have a role in the development of mental symptoms in severe cases of myotonic dystrophy
Caution: It is uncertain whether Met-1 or Met-16 is the initiator

Explore the universe of human proteins at neXtProt for DMWD: NX_Q09019

Explore proteomics data for DMWD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DMWD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004934.1  
    ENSEMBL proteins: 
     ENSP00000366964   ENSP00000270223   ENSP00000444820   ENSP00000473377   ENSP00000473426  
     ENSP00000473415  

    DMWD Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DMWD

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    LSBio Antibodies in human, mouse, rat for DMWD

    DMWD Assay Products:

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    Cloud-Clone Corp. CLIAs for DMWD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q09019

    ProtoNet protein and cluster: Q09019

    UniProtKB/Swiss-Prot: DMWD_HUMAN, Q09019
    Similarity: Contains 5 WD repeats


    DMWD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMWD_HUMAN, Q09019
    Function: Could have a regulatory function in meiosis

         Genatlas biochemistry entry for DMWD:
    myotonin-protein kinase related (DMR-N9 homolog),including a locus control region (see LCR-DMWD)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    DMWD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMWD
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    miRNA
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    miRTarBase miRNAs that target DMWD:
    hsa-mir-10b-5p (MIRT047468), hsa-mir-183-5p (MIRT047072), hsa-mir-222-3p (MIRT046591), hsa-mir-93-3p (MIRT038872)

    Block miRNA regulation of human, mouse, rat DMWD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMWD (see all 29):
    hsa-miR-194* hsa-miR-1321 hsa-miR-2110 hsa-miR-200a hsa-miR-449a hsa-miR-141 hsa-miR-890 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidDMWD 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMWD

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMWD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    DMWD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMWD
    Interactions:

        Search GeneGlobe Interaction Network for DMWD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DMWD (Q090192, 3 ENSP000002702234) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000226589P266403, ENSP000004033594I2D: score=2 STRING: ENSP00000403359
    ENSG00000224264P266403, ENSP000004011214I2D: score=2 STRING: ENSP00000401121
    ENSG00000096171P266403I2D: score=2 
    ENSG00000231116P266403I2D: score=2 
    VARSP266403I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007126meiotic nuclear division ----

    DMWD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMWD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DMWD gene: 
    NM_004943.1  

    Unigene Cluster for DMWD:

    Dystrophia myotonica, WD repeat containing
    Hs.515474  [show with all ESTs]
    Unigene Representative Sequence: NM_004943
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377735(uc021uwc.1) ENST00000270223(uc002pdj.1 uc010eko.1)
    ENST00000537879 ENST00000602829 ENST00000601370 ENST00000597053 ENST00000602469
    ENST00000598237
    miRNA
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    Block miRNA regulation of human, mouse, rat DMWD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMWD (see all 29):
    hsa-miR-194* hsa-miR-1321 hsa-miR-2110 hsa-miR-200a hsa-miR-449a hsa-miR-141 hsa-miR-890 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidDMWD 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMWD
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DMWD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMWD
      QuantiTect SYBR Green Assays in human, mouse, rat DMWD
      QuantiFast Probe-based Assays in human, mouse, rat DMWD

    Additional mRNA sequence: 

    AK309497.1 BC019266.1 BC041034.1 BT006798.1 L19267.1 

    8 DOTS entries:

    DT.100747111  DT.100821288  DT.75100948  DT.97822256  DT.100031718  DT.100640724  DT.99954238  DT.99969962 

    Selected AceView cDNA sequences (see all 311):

    NM_175875 BM966765 AI659650 BQ919325 BM737690 BX420052 CF136022 BQ953617 
    BI770992 BF339767 M87312 BE264823 BQ070737 CR622406 BC019266 AI686153 
    BX098437 BG951959 AI027251 AI470253 BQ185710 BM696765 BQ940299 AI433256 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DMWD    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                    -                                 
    SP2:                                                      
    SP3:                                      -               


    ECgene alternative splicing isoforms for DMWD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DMWD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGGTCA
    DMWD Expression
    About this image

    DMWD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMWD Protein Expression

    Genevestigator expression for DMWD

    SOURCE GeneReport for Unigene cluster: Hs.515474

    UniProtKB/Swiss-Prot: DMWD_HUMAN, Q09019
    Tissue specificity: Strongest expression in brain, liver, and testis. Also expressed in kidney and spleen

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DMWD gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmwd1 , 5 dystrophia myotonica-containing WD repeat motif1, 5 84.82(n)1
    90.77(a)1
      7 (9.46 cM)5
    134011  NM_010058.21  NP_034188.21 
     190762495 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    67(a)
    1 → many
    GL343962.1(60033-70182)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5719961 dystrophia myotonica WD repeat-containing protein-like 64.06(n)
    64.38(a)
      571996  XM_695648.6  XP_700740.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64206
    --
    30(a)
    1 → many
    3R(22546192-22550937)
    worm
    (Caenorhabditis elegans)
    Secernentea wdr-206
    Protein HPO-22, isoform b (hpo-22) mRNA, complete ...
    30(a)
    1 → many
    V(10130468-10134148) WBGene00007428


    ENSEMBL Gene Tree for DMWD (if available)
    TreeFam Gene Tree for DMWD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DMWD gene
    WDR202  ENSG000002684342  
    2 SIMAP similar genes for DMWD using alignment to 8 protein entries:     DMWD_HUMAN (see all proteins):
    WDR20    DKFZp686P0251

    DMWD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DMWD (see all 230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127280521,2
    C--46287896(+) AGTCCG/TACCTC 1 -- int10--------
    rs1113503521,2
    C--46287897(+) GTCCTA/CCCTCT 1 -- spd10--------
    rs1843107871,2
    C--46287934(+) CCAACA/TTCCTT 2 S C mis10--------
    rs777536411,2
    C,F--46287965(+) TCCTCG/ATCTGT 2 /D syn11Minor allele frequency- A:0.00NA 4552
    rs129833561,2
    C,H--46287981(+) ACGGAG/CACAGA 1 -- int14Minor allele frequency- C:0.00NS EA 372
    rs582456981,2
    C--46288087(+) CTCTAC/AGATTC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1899816601,2
    --46288188(+) GCTCCA/GAACTT 1 -- int10--------
    rs1173130811,2
    C,F--46288200(+) CAAGAT/CGCCAG 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1811918771,2
    --46288235(+) CCCAAC/TGCCAC 1 -- int10--------
    rs1456083321,2
    --46288280(+) CCCATC/TCTACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DMWD (46286205 - 46296060 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DMWD:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3957n71CNV Loss21882294
    nsv912166CNV Loss21882294
    dgv3954n71CNV Loss21882294
    dgv3956n71CNV Loss21882294
    nsv912170CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DMWD
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609857    OMIM disorders: --

    6 diseases for DMWD:    About MalaCards
    triple-a syndrome    myotonic dystrophy type 1    myotonic dystrophy    mental retardation
    atherosclerosis    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for DMWD:
    Myotonic dystrophy

    DMWD for disorders           About GeneDecksing

    Genetic Association Database (GAD): DMWD

    Export disorders for DMWD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DMWD gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DMWD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Myotonic dystrophy is associated with a reduced level of RNA from the DMWD allele adjacent to the expanded repeat. (PubMed id 10400997)1, 4 Alwazzan M....Brook J.D. (Hum. Mol. Genet. 1999)
    3. Genomic organization and transcriptional units at the myotonic dystrophy locus. (PubMed id 7905855)1, 2 Shaw D.J....Brook J.D. (Genomics 1993)
    4. Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene. (PubMed id 8499920)1, 2 Mahadevan M.S.... Korneluk R.G. (Hum. Mol. Genet. 1993)
    5. Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs. (PubMed id 1302022)1, 3 Jansen G.... Wieringa B. (Nat. Genet. 1992)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. (PubMed id 21183687)1 Joo H.Y....Wang H. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1762 HGNC: 2936 AceView: DMPKandSIX5andDMWD Ensembl:ENSG00000185800 euGenes: HUgn1762
    ECgene: DMWD H-InvDB: DMWD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DMWD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DMWD gene:
    Search GeneIP for patents involving DMWD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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