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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DMTN Gene

protein-coding   GIFtS: 38
GCID: GC08P021907

Dematin Actin Binding Protein

(Previous name: erythrocyte membrane protein band 4.9 (dematin))
(Previous symbol: EPB49)
  Search for DMTN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dematin Actin Binding Protein1 2     Dematin Actin-Binding Protein2 3
EPB491 2 3 5     dematin2
DMT2 3 5     Erythrocyte Membrane Protein Band 4.93
Erythrocyte Membrane Protein Band 4.9 (Dematin)1 2     

External Ids:    HGNC: 33821   Entrez Gene: 20392   Ensembl: ENSG000001588567   OMIM: 1253055   UniProtKB: Q084953   

Export aliases for DMTN gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DMTN Gene:
Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its
actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after
dephosphorylation (Rana et al., 1993 (PubMed 8341682)).(supplied by OMIM, Apr 2009)

GeneCards Summary for DMTN Gene: 
DMTN (dematin actin binding protein) is a protein-coding gene. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495
Function: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles
formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by
the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1,
and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in
maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties.
Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA
activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense
tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation
of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading,
motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation

Gene Wiki entry for DMTN (EPB49) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DMTN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DMTN promoter sequence
   Search SABiosciences Chromatin IP Primers for DMTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.1

DMTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMTN gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P021907:  view genomic region     (about GC identifiers)

Start:
21,906,506 bp from pter      End:
21,940,038 bp from pter
Size:
33,533 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495 (See protein sequence)
Recommended Name: Dematin  
Size: 405 amino acids; 45514 Da
Subunit: Monomeric (isoform 2); under reducing conditions. Self-associates. Exists under oxidizing condition as a
trimer of two isoforms 2 and isoform 1 linked by disulfide bonds (Probable). Found in a complex with DMTN,
F-actin and spectrin. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with F-actin, ITPKB, RASGRF2 and
spectrin. Isoform 2 interacts with SLC2A1 (via C-terminus cytoplasmic region). Isoform 1 and isoform 2 interact
(phosphorylated form) with plasmodium berghei 14-3-3 protein; the interaction occurs in a PKA-dependent manner
Subcellular location: Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region (By similarity). Cytoplasm,
cytoskeleton. Cell membrane. Membrane (By similarity). Endomembrane system. Cell projection (By similarity).
Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular
membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in
platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the
parasitophorous vacuol in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum
development
2 PDB 3D structures from and Proteopedia for DMTN:
1QZP (3D)        1ZV6 (3D)    
Secondary accessions: A8K0T5 B3KP70 B3KRH3 E9PEJ0 Q13215 Q9BRE3
Alternative splicing: 3 isoforms:  Q08495-1   Q08495-2   Q08495-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DMTN: NX_Q08495

Explore proteomics data for DMTN at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the
    N-terminal core domain, and leads to the inhibition of its actin bundling activity
  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08495

  • DMTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DMTN Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001107607.1  NP_001107608.1  NP_001107609.1  NP_001107610.1  NP_001107611.1  NP_001969.2  

    ENSEMBL proteins: 
     ENSP00000428063   ENSP00000429116   ENSP00000430600   ENSP00000397904   ENSP00000430618  
     ENSP00000429234   ENSP00000428733   ENSP00000430382   ENSP00000428415   ENSP00000265800  
     ENSP00000429948   ENSP00000427866   ENSP00000429377   ENSP00000430609   ENSP00000370879  
     ENSP00000416111   ENSP00000350977   ENSP00000401291  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA--
    GO:0005884actin filament IDA--
    GO:0005886plasma membrane IDA--

    DMTN for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003128 Villin_headpiece

    Graphical View of Domain Structure for InterPro Entry Q08495

    ProtoNet protein and cluster: Q08495

    1 Blocks protein domain: IPB003128 Villin headpiece

    UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495
    Domain: Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin
    and necessary for actin bundling activity
    Similarity: Belongs to the villin/gelsolin family
    Similarity: Contains 1 HP (headpiece) domain


    DMTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEMA_HUMAN, Q08495
    Function: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles
    formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by
    the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1,
    and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in
    maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties.
    Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA
    activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense
    tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation
    of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading,
    motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA19241372
    GO:0005102receptor binding IDA18347014
    GO:0005515protein binding IPI18347014
    GO:0030507spectrin binding IDA--
    GO:0043621protein self-association IDA--
         
    DMTN for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Epb4.9):
     hematopoietic system 

    DMTN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dmtntm1Ahc for DMTN

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/13 Interacting proteins for DMTN (Q084952, 3 ENSP000002658004) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTOV1Q86YD12, 3MINT-64691 I2D: score=5 
    SNRPD2P623162, 3MINT-64072 I2D: score=4 
    PROCRQ9UNN82, 3, ENSP000002169684MINT-64074 I2D: score=5 STRING: ENSP00000216968
    DYNC1LI2O432373, ENSP000002581984I2D: score=4 STRING: ENSP00000258198
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly ISS--
    GO:0007010cytoskeleton organization TAS7615546
    GO:0008360regulation of cell shape IMP10565303
    GO:0010591regulation of lamellipodium assembly IMP10565303
    GO:0010763positive regulation of fibroblast migration ISS--

    DMTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DMTN (DEMA)

    Search CenterWatch for drugs/clinical trials and news about DMTN / DEMA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DMTN gene (6 alternative transcripts): 
    NM_001114135.2  NM_001114136.1  NM_001114137.1  NM_001114138.1  NM_001114139.1  NM_001978.2  

    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000522148 ENST00000523300 ENST00000519959 ENST00000519850 ENST00000443491(uc011kys.1 uc022ass.1)
    ENST00000518816 ENST00000517600 ENST00000523782 ENST00000520856 ENST00000523623
    ENST00000520174 ENST00000517804 ENST00000265800(uc022ast.1 uc022asw.1 uc022asx.1 uc022asy.1)
    ENST00000517418 ENST00000523266 ENST00000519907 ENST00000517305 ENST00000522340

    miRNA
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    24/168 AceView cDNA sequences (see all 168):

    BF510971 CK820030 AL138164 H65304 BX644547 F03346 AA383081 CB155183 
    CD674915 AW473097 F04623 F08518 BM141877 F30467 T34776 R40779 
    BI823974 BG055677 AW339606 BX406256 AW473094 H26969 BX406966 BV203949 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for DMTN (see all 20)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^
    SP1:                                                              -     -           -     -     -                                               -     -         
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -     -     -                                               -     -         
    SP3:                                -     -     -     -     -     -     -     -     -     -     -                 -                             -     -         
    SP4:                                                  -     -     -     -     -     -     -     -                 -                             -     -         
    SP5:                                                                                                                                                            

    ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                              -                     


    ECgene alternative splicing isoforms for DMTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DMTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DMTN Expression
    About this image


    See DMTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DMTN

    UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495
    Tissue specificity: Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle,
    and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DMTN gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epb4.91 , 5 erythrocyte protein band 4.91, 5 89.96(n)1
    96.05(a)1
      14 (36.32 cM)5
    138291  NM_001252662.11  NP_001239591.11 
     706021845 
    chicken
    (Gallus gallus)
    Aves LOC7765421 dematin-like 77.55(n)
    82.82(a)
      776542  XM_003643470.1  XP_003643518.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPB496
    erythrocyte membrane protein band 4.9 (dematin)
    75(a)
    1 ↔ 1
    GL343858.1(1483-21538)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88952 Xenopus laevis transcribed sequence with weak similarity more 75(n)    CD326858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj78f012 Transcribed sequence with weak similarity to protein more 75.57(n)    CD598541.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-115b6
    Unc-115a6
    --
    7(a)
    10(a)
    many ↔ many
    many ↔ many
    3R(5512782-5518497)
    3R(5520444-5531165)


    ENSEMBL Gene Tree for DMTN (if available)
    TreeFam Gene Tree for DMTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DMTN gene
    ABLIM32  LIMS12  LIMS3L2  LDB32  FHL52  LPXN2  PDLIM52  ENSG000002572072  
    ABLIM22  LIMS22  FHL22  ABLIM12  PDLIM72  FHL32  FHL12  LIMS32  
    TGFB1I12  PXN2  
    3 SIMAP similar genes for DMTN using alignment to 10 protein entries:     DEMA_HUMAN (see all proteins):
    VIL1    SVIL    ABLIM1

    DMTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/299 SNPs in DMTN are shown (see all 299)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782924661,2
    C,F--21909133(+) AAGATT/CCCCTC 1 -- us2k11Minor allele frequency- C:0.20WA 118
    rs561769651,2
    C,F--21909218(+) CTGCTC/TTCTGC 1 -- us2k16Minor allele frequency- T:0.28NA CSA WA EA 364
    rs561513141,2
    C--21909244(+) TGCACC/TGTGGC 1 -- us2k16Minor allele frequency- T:0.36NA CSA WA EA 363
    rs563174391,2
    C,F--21909280(+) TATCCA/GCTCGC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1440628401,2
    C--21909314(+) TCAACA/GCTGCC 1 -- us2k10--------
    rs1486284371,2
    --21909337(+) ACATCC/TGAGTT 1 -- us2k10--------
    rs1840424051,2
    --21909385(+) ACCCAC/TGCCAC 1 -- us2k10--------
    rs1890177631,2
    --21909398(+) TATCCC/TGGCCA 1 -- us2k10--------
    rs1171919421,2
    C,F--21909453(+) GTCTCC/TCTATT 1 -- us2k11Minor allele frequency- T:0.13NA 120
    rs1412211751,2
    --21909486(+) CTTTAA/GGAATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DMTN (21906506 - 21940038 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DMTN: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DMTN
    DNA2.0 Custom Variant and Variant Library Synthesis for DMTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DMTN for disorders           About MalaCards
    OMIM gene information: 125305    OMIM disorders: --


    DMTN for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for DMTN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spherocytosis hereditary 72.9 1 7615546 (1)
    anemia hemolytic 42.5 1 7615546 (1)
    prostate cancer 5.43 2 10565303 (2)


    Export disorders for DMTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DMTN gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with DMTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human erythroid dematin reveals another member of the villin family. (PubMed id 8341682)1, 2, 3, 9 Rana A.P.... Chishti A.H. (1993)
    2. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. (PubMed id 19241372)1, 2, 9 Chen L....McKnight C.J. (2009)
    3. Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression. (PubMed id 10565303)1, 2, 9 Lutchman M....Chishti A.H. (1999)
    4. The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site. (PubMed id 14660664)1, 2, 9 Frank B.S....McKnight C.J. (2004)
    5. Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1. (PubMed id 18347014)1, 2, 9 Khan A.A....Chishti A.H. (2008)
    6. Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily. (PubMed id 7615546)1, 2, 9 Azim A.C.... Chishti A.H. (1995)
    7. The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). (PubMed id 23355471)1, 2 Chen L.... McKnight C.J. (2013)
    8. Identification of a novel role for dematin in regulati ng red cell membrane function by modulating spectrin-actin interaction. (PubMed id 22927433)1, 2 Koshino I....Takakuwa Y. (2012)
    9. Headpiece domain of dematin regulates calcium mobiliza tion and signaling in platelets. (PubMed id 23060452)1, 2 Wieschhaus A.J....Chishti A.H. (2012)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2039 HGNC: 3382 AceView: EPB49 Ensembl:ENSG00000158856 euGenes: HUgn2039
    ECgene: DMTN H-InvDB: DMTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DMTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DMTN gene:
    Search GeneIP for patents involving DMTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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