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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DMTF1 Gene

protein-coding   GIFtS: 60
GCID: GC07P086781

cyclin D binding myb-like transcription factor 1
 Explore 11 diseases affiliated with
DMTF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DMTF1    

Aliases
for DMTF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin D Binding Myb-Like Transcription Factor 11 2     Cyclin-D-Interacting Myb-Like Protein 12 3
DMP11 2 3     HDMTF11
HDMP11     Cyclin D-Binding Myb-Like Protein2
DMTF1 2     Cyclin-D-Binding Myb-Like Transcription Factor 12

External Ids:    HGNC: 146031   Entrez Gene: 99882   Ensembl: ENSG000001351647   OMIM: 6084915   UniProtKB: Q9Y2223   
ORGUL members:         
NONCODE:n407055    

Export aliases for DMTF1 gene to outside databases

Previous GC identifers: GC07P085317 GC07P086379 GC07P086393 GC07P086426 GC07P086620 GC07P081392


Summaries
for DMTF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DMTF1:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and
two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic
Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53
pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may
play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by
binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and
is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby
promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By
similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize
transcriptional activation by isoform 1

Gene Wiki entry for DMTF1


Genomic Views
for DMTF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DMTF1 gene promoter:
         Pax-5   NRF-2   p53   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): DMTF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DMTF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21

DMTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMTF1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086781:  view genomic region     (about GC identifiers)

Start:
 86,781,677 bp from pter      End:
 86,825,653 bp from pter
Size:
 43,977 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,113,189-86,157,158     

Proteins
for DMTF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222 (See protein sequence)
Recommended Name: Cyclin-D-binding Myb-like transcription factor 1  
Size: 760 amino acids; 84471 Da
Subunit: Interacts with the D-type cyclins CCND1, CCND2 and CCND3 (By similarity). Interaction with D-type cyclins may
modulate transcriptional activation by this protein (By similarity)
Subcellular location: Nucleus
Developmental stage: Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of
isoform 1 and isoform 3 remain constant
Sequence caution: Sequence=BAD92467.1; Type=Erroneous translation; Note=Wrong choice of frame;
1 PDB 3D structure from and Proteopedia for DMTF1:
2LLK (3D)    
Secondary accessions: B2RBE1 B4DJS5 Q05C48 Q59G79 Q6IS13 Q969T2 Q9H2Z2 Q9H2Z3
Alternative splicing: 5 isoforms:  Q9Y222-1   Q9Y222-2   Q9Y222-3   Q9Y222-4   Q9Y222-5   

Explore the universe of human proteins at neXtProt for DMTF1: NX_Q9Y222

Post-translational modifications:

  • Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the
    • cyclin-D1/CDK4 complex (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y222

    • DMTF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135798.1  NP_001135799.1  NP_066968.3  

    ENSEMBL proteins: 
     ENSP00000332171   ENSP00000402627   ENSP00000389774   ENSP00000464596   ENSP00000401129  
     ENSP00000411908   ENSP00000406384   ENSP00000411858   ENSP00000448775   ENSP00000463638  
     ENSP00000397490   ENSP00000413118   ENSP00000412734   ENSP00000387712   ENSP00000416307  
     ENSP00000412532   ENSP00000464092   ENSP00000415382   ENSP00000413722   ENSP00000378193  
     ENSP00000463735   ENSP00000393370   ENSP00000461920   ENSP00000407941   ENSP00000416499  
     ENSP00000410288   ENSP00000463239   ENSP00000378192   ENSP00000396570   ENSP00000415910  

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    Uscn Proteins for DMTF1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10095122
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    DMTF1 for ontologies           About GeneDecksing



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    Uscn Antibodies for DMTF1
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    Protein Domains /
    Families
    for DMTF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DMTF1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017877 Myb-like_dom
     IPR001005 SANT/Myb
     IPR009057 Homeodomain-like
     IPR017930 Myb_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y222

    ProtoNet protein and cluster: Q9Y222

    UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
    Similarity: Belongs to the DMTF1 family
    Similarity: Contains 1 HTH myb-type DNA-binding domain
    Similarity: Contains 2 Myb-like domains


    Function
    for DMTF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
    Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby
    promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By
    similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize
    transcriptional activation by isoform 1

    miRNA
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    hsa-miR-549 hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-372 hsa-miR-424
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10095122


    DMTF1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DMTF1:
     Enable proliferation in B-Raf  

    Animal Models:
         Mouse knock-out Dmtf1tm1Cjs for DMTF1
         12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dmtf1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     immune system  integument  mortality/aging  nervous system  renal/urinary system 
     reproductive system  tumorigenesis 

    DMTF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DMTF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Validated transcriptional targets of AP1 family members Fra1 and Fra2
    		Validated transcriptional targets of AP1 family members Fra1 and Fra21.00


    1 BioSystems Pathway for DMTF1 
        Validated transcriptional targets of AP1 family members Fra1 and Fra2


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for DMTF1 (Q9Y2222, 3 ENSP000003321714) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61915 I2D: score=3 
    CCND3P302813, ENSP000003620824I2D: score=2 STRING: ENSP00000362082
    CCND1P243853, ENSP000002275074I2D: score=2 STRING: ENSP00000227507
    CCND2P302793, ENSP000002612544I2D: score=2 STRING: ENSP00000261254
    FOSENSP000003062454STRING: ENSP00000306245
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS10095122
    GO:0007049cell cycle IEA--


    DMTF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DMTF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DMTF1
    Search CenterWatch for drugs/clinical trials and news about DMTF1 

    Transcripts
    for DMTF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DMTF1 gene (3 alternative transcripts): 
    NM_001142326.1  NM_001142327.1  NM_021145.3  

    Unigene Cluster for DMTF1:

    Cyclin D binding myb-like transcription factor 1
    Hs.196129  [show with all ESTs]
    Unigene Representative Sequence: AK126664
    18/41 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):
    ENST00000331242(uc003uih.3 uc011khb.2) ENST00000413276 ENST00000447863(uc003uii.3)
    ENST00000579677(uc003uij.3) ENST00000446796 ENST00000425406(uc003uik.3)
    ENST00000420131 ENST00000414630 ENST00000547146 ENST00000579850 ENST00000453049
    ENST00000428819 ENST00000448598 ENST00000449088 ENST00000430405 ENST00000432937
    ENST00000584619 ENST00000432366

    miRNA
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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate DMTF1 (see all 49):
    hsa-miR-549 hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-372 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: DMTF1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AB209230.1 AF052102.1 AF084530.1 AF202144.1 AF202145.1 AK002073.1 AK057917.1 AK095828.1 
    AK123259.1 AK126664.1 AK295144.1 AK296211.1 AK314622.1 BC007418.2 BC007447.2 BC029370.1 
    BC070064.1 NR_024549.1 NR_024550.1 

    24/29 DOTS entries (see all 29):

    DT.87015777  DT.87013858  DT.92438795  DT.436161  DT.92438790  DT.65284162  DT.95166826  DT.102843239 
    DT.407666  DT.100822911  DT.100822916  DT.40274110  DT.121059998  DT.102843241  DT.121060067  DT.100822910 
    DT.121059967  DT.121060054  DT.100822904  DT.121059994  DT.121060031  DT.407668  DT.422392  DT.100725113 

    24/224 AceView cDNA sequences (see all 224):

    AA906948 BX479606 CA447940 AA251625 AA489019 CA397983 AK123259 AI337593 
    AA405066 AW129614 BM679076 AI685126 BF057846 CA950096 CB145584 AA806772 
    BM972940 CA393359 BX281436 CA336437 AF202144 BX102382 AW027430 BM473684 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for DMTF1 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a ·
    SP1:                                                                                                                                                            
    SP2:                    -     -     -     -     -     -     -                 -                                                                                 
    SP3:                    -     -     -     -     -     -     -                                                                                                   
    SP4:                    -                 -     -     -     -                 -                                                                                 
    SP5:                    -     -           -     -     -     -                 -                                                                                 

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b
    SP1:                    -     -                                                                                                               
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for DMTF1

    Expression
    for DMTF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DMTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCATTTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DMTF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DMTF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DMTF1

    SOURCE GeneReport for Unigene cluster: Hs.196129

    UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
    Tissue specificity: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and
    small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS
    including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the
    predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral
    blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell
    types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion,
    strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs
    in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in
    leukemic blasts from patients with abnormalities of the long arm of chromosome 7

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    Orthologs
    for DMTF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DMTF1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DMTF11 cyclin D binding myb-like transcription factor 1 80.81(n)
    88.54(a)    		   418646  NM_001080863.2  NP_001074332.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DMTF16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343559.1(367876-394302)
    zebrafish
    (Danio rerio)    		 Actinopterygii dmtf11 cyclin D binding myb-like transcription factor 1 65.03(n)
    68.46(a)    		   436938  NM_001002665.1  NP_001002665.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G410206
    		 myb family transcription factor
    		 12(a)
    		 1 → many
    		 5(16425883-16427797)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 MYB family transcription factor, putative, express...
    		 11(a)
    		 1 → many
    		 6(11452024-11460167)


    ENSEMBL Gene Tree for DMTF1 (if available)
    TreeFam Gene Tree for DMTF1 (if available) 

    Paralogs
    for DMTF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DMTF1 gene
    TTF12  

    DMTF1 for paralogs           About GeneDecksing



    Genomic Variants
    for DMTF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/794 NCBI SNPs in DMTF1 are shown (see all 794)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs770922201,2
    		F,--86111957(+) ATACAC/TGTCAG 5 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1118662471,2
    		--86112176(+) AAAATG/TGAATG 5 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs119713631,2
    		C,F,H,--86112319(+) CATTTG/ATAAAC 5 -- us2k110Minor allele frequency- A:0.03NS EA NA WA 1168
    rs175158821,2
    		C--86112690(+) TTTATT/-ACGGC 5 -- us2k11Minor allele frequency- -:0.00NA 2
    rs733901381,2
    		C,--86112787(+) CAGAGG/AACACA 5 -- us2k11Minor allele frequency- A:0.50WA 2
    rs755077551,2
    		F,--86112880(+) TCCCTG/ATTTTC 5 -- us2k11Minor allele frequency- A:0.02WA 118
    rs175158961,2
    		F,--86113221(+) CGTGCG/AGGGAG 5 -- ut51 us2k1 nc-transcript-variant1Minor allele frequency- A:0.20EA 120
    rs119723601,2
    		C,F,H,--86113442(+) GTGGAG/TCCTGT 5 -- int1 ut514Minor allele frequency- T:0.02NS EA 396
    rs1134589681,2
    		--86113651(+) ACAGCG/AGCGAT 5 -- int13Minor allele frequency- A:0.02CSA NA EA 242
    rs746876851,2
    		F,--86113947(+) TCCCTC/GGTTTG 5 -- int11Minor allele frequency- G:0.06NA 120

    HapMap Linkage Disequilibrium report for DMTF1 (86781677 - 86825653 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DMTF1
         1 CNV: 0106

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    Disorders / Diseases
    for DMTF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DMTF1 for disorders           About GeneDecksing

    OMIM gene information: 608491    OMIM disorders: --

    11 diseases for DMTF1:    About MalaCards
    lung cancer    non-small cell lung carcinoma    dental fluorosis    dental caries
    corpus callosum    lung carcinoma    myeloid leukemia    breast cancer
    carcinoma    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DMTF1:
    Dental fluorosis

    1 Novoseek disease relationship for DMTF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 22.3 14 17237816 (3), 19816943 (3), 18598225 (2), 17546045 (1) (see all 7)

    Genetic Association Database (GAD): DMTF1
    Human Genome Epidemiology (HuGE) Navigator: DMTF1 (3 documents)

    Export disorders for DMTF1 gene to outside databases

    Publications
    for DMTF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DMTF1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with DMTF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). (PubMed id 10095122)1, 2, 3, 9 Bodner S.M.... Look A.T. (1999)
    2. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (PubMed id 17936562)1, 2, 9 Mallakin A....Inoue K. (2007)
    3. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. (PubMed id 12917399)1, 2, 9 Tschan M.P.... Torbett B.E. (2003)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Single nucleotide polymorphisms in breast cancer. (PubMed id 15010895)1, 4 Forsti A....Kumar R. (2004)
    6. Dmp1 and tumor suppression. (PubMed id 17237816)1, 9 Inoue K....Frazier D.P. (2007)
    7. Role of DMP1 and its future in lung cancer diagnostics. (PubMed id 18598225)1, 9 Sugiyama T....Inoue K. (2008)
    8. Dmp1 physically interacts with p53 and positively regu lates p53's stability, nuclear localization, and function. (PubMed id 22331460)1 Frazier D.P....Inoue K. (2012)
    9. Genome-wide association study to identify common varia nts associated with brachial circumference: a meta-analysis of 14 cohorts. (PubMed id 22479309)1 Boraska V....Zeggini E. (2012)
    10. Meta-analysis of genome-wide association data of bipo lar disorder and major depressive disorder. (PubMed id 20351715)1 Liu Y....Sullivan P.F. (2010)

    External Searches for DMTF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DMTF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9988 HGNC: 14603 AceView: DMTF1 Ensembl:ENSG00000135164 euGenes: HUgn9988
    ECgene: DMTF1 H-InvDB: DMTF1

    Other Databases showing DMTF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DMTF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DMTF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DMTF1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DMTF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DMTF1 gene:
    Search GeneIP for patents involving DMTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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