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Aliases for DMTF1 Gene

Aliases for DMTF1 Gene

  • Cyclin D Binding Myb-Like Transcription Factor 1 2 3
  • DMP1 3 4 6
  • Cyclin-D-Interacting Myb-Like Protein 1 3 4
  • Cyclin D-Binding Myb-Like Protein 2 3
  • HDMTF1 3 4
  • HDMP1 3 4
  • Cyclin-D-Binding Myb-Like Transcription Factor 1 3
  • DMTF 3
  • MRUL 3

External Ids for DMTF1 Gene

Summaries for DMTF1 Gene

Entrez Gene Summary for DMTF1 Gene

  • This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for DMTF1 Gene

DMTF1 (Cyclin D Binding Myb-Like Transcription Factor 1) is a Protein Coding gene. Diseases associated with DMTF1 include lung cancer and dental fluorosis. Among its related pathways are Degradation of the extracellular matrix and ECM proteoglycans. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is TTF1.

UniProtKB/Swiss-Prot for DMTF1 Gene

  • Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5-CCCG[GT]ATGT-3 (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Gene Wiki entry for DMTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMTF1 Gene

Genomics for DMTF1 Gene

Genomic Location for DMTF1 Gene

Start:
87,152,361 bp from pter
End:
87,196,337 bp from pter
Size:
43,977 bases
Orientation:
Plus strand

Genomic View for DMTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMTF1 Gene

Regulatory Elements for DMTF1 Gene

Proteins for DMTF1 Gene

  • Protein details for DMTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y222-DMTF1_HUMAN
    Recommended name:
    Cyclin-D-binding Myb-like transcription factor 1
    Protein Accession:
    Q9Y222
    Secondary Accessions:
    • B2RBE1
    • B4DJS5
    • Q05C48
    • Q59G79
    • Q6IS13
    • Q969T2
    • Q9H2Z2
    • Q9H2Z3

    Protein attributes for DMTF1 Gene

    Size:
    760 amino acids
    Molecular mass:
    84471 Da
    Quaternary structure:
    • Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.
    SequenceCaution:
    • Sequence=BAD92467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMTF1 Gene

    Alternative splice isoforms for DMTF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMTF1 Gene

Proteomics data for DMTF1 Gene at MOPED

Post-translational modifications for DMTF1 Gene

  • Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.

No data available for DME Specific Peptides for DMTF1 Gene

Domains for DMTF1 Gene

Protein Domains for DMTF1 Gene

UniProtKB/Swiss-Prot:

DMTF1_HUMAN
Domain:
  • Contains 1 HTH myb-type DNA-binding domain.:
    • Q9Y222
  • Contains 2 Myb-like domains.:
    • Q9Y222
Family:
  • Belongs to the DMTF1 family.:
    • Q9Y222
genes like me logo Genes that share domains with DMTF1: view

No data available for Gene Families for DMTF1 Gene

Function for DMTF1 Gene

Molecular function for DMTF1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5-CCCG[GT]ATGT-3 (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Gene Ontology (GO) - Molecular Function for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10095122
genes like me logo Genes that share ontologies with DMTF1: view
genes like me logo Genes that share phenotypes with DMTF1: view

Animal Models for DMTF1 Gene

MGI Knock Outs for DMTF1:

miRNA for DMTF1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DMTF1 Gene

Localization for DMTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMTF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMTF1 Gene COMPARTMENTS Subcellular localization image for DMTF1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10095122
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DMTF1: view

Pathways for DMTF1 Gene

genes like me logo Genes that share pathways with DMTF1: view

Pathways by source for DMTF1 Gene

Gene Ontology (GO) - Biological Process for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10095122
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with DMTF1: view

Transcripts for DMTF1 Gene

Unigene Clusters for DMTF1 Gene

Cyclin D binding myb-like transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMTF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a ·
SP1:
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13:
SP14: - - - -
SP15: - - - - -
SP16: - - -
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21: - - - -
SP22:

Relevant External Links for DMTF1 Gene

GeneLoc Exon Structure for
DMTF1
ECgene alternative splicing isoforms for
DMTF1

Expression for DMTF1 Gene

mRNA expression in normal human tissues for DMTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMTF1 Gene

SOURCE GeneReport for Unigene cluster for DMTF1 Gene Hs.196129

mRNA Expression by UniProt/SwissProt for DMTF1 Gene

Q9Y222-DMTF1_HUMAN
Tissue specificity: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.
genes like me logo Genes that share expressions with DMTF1: view

Orthologs for DMTF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DMTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMTF1 36
  • 99.74 (n)
  • 99.74 (a)
DMTF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMTF1 36
  • 93.76 (n)
  • 95.78 (a)
DMTF1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMTF1 36
  • 94.64 (n)
  • 97.23 (a)
DMTF1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmtf1 36
  • 91.84 (n)
  • 95.26 (a)
Dmtf1 16
Dmtf1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMTF1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMTF1 37
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DMTF1 36
  • 80.81 (n)
  • 88.54 (a)
DMTF1 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMTF1 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmtf1 36
  • 69.28 (n)
  • 70.58 (a)
zebrafish
(Danio rerio)
Actinopterygii dmtf1 36
  • 67.34 (n)
  • 73.08 (a)
dmtf1 37
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToMany
Species with no ortholog for DMTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DMTF1 Gene

ENSEMBL:
Gene Tree for DMTF1 (if available)
TreeFam:
Gene Tree for DMTF1 (if available)

Paralogs for DMTF1 Gene

Paralogs for DMTF1 Gene

genes like me logo Genes that share paralogs with DMTF1: view

Variants for DMTF1 Gene

Sequence variations from dbSNP and Humsavar for DMTF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs16627 -- 87,159,411(-) AAAAT(-/TCTC)TCTAT intron-variant
rs740303 -- 87,193,446(+) ACAGT(G/T)CTTCC intron-variant
rs765968 -- 87,165,408(+) TTTCA(A/G)TATGA intron-variant
rs973044 -- 87,170,864(+) TGTAT(A/G)TATGT intron-variant
rs1058972 -- 87,160,110(-) GTAGA(A/G)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMTF1 Gene

Variant ID Type Subtype PubMed ID
nsv527889 CNV Gain 19592680
nsv483124 CNV Gain 15286789
nsv888676 CNV Gain 21882294
nsv888677 CNV Gain 21882294

Relevant External Links for DMTF1 Gene

HapMap Linkage Disequilibrium report
DMTF1

Disorders for DMTF1 Gene

(1) University of Copenhagen DISEASES for DMTF1 Gene

(1) Novoseek inferred disease relationships for DMTF1 Gene

Disease -log(P) Hits PubMed IDs
tumors 22.3 12

Relevant External Links for DMTF1

Genetic Association Database (GAD)
DMTF1
Human Genome Epidemiology (HuGE) Navigator
DMTF1
genes like me logo Genes that share disorders with DMTF1: view

No data available for UniProtKB/Swiss-Prot for DMTF1 Gene

Publications for DMTF1 Gene

  1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). (PMID: 10095122) Bodner S.M. … Look A.T. (Gene 1999) 2 3 4 23
  2. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. (PMID: 12917399) Tschan M.P. … Torbett B.E. (J. Biol. Chem. 2003) 3 4 23
  3. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (PMID: 17936562) Mallakin A. … Inoue K. (Cancer Cell 2007) 3 4 23
  4. Role of DMP1 and its future in lung cancer diagnostics. (PMID: 18598225) Sugiyama T. … Inoue K. (Expert Rev. Mol. Diagn. 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DMTF1 Gene

  • Addgene plasmids for DMTF1

Sources for DMTF1 Gene

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