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Aliases for DMTF1 Gene

Aliases for DMTF1 Gene

  • Cyclin D Binding Myb Like Transcription Factor 1 2 3 5
  • Cyclin-D-Interacting Myb-Like Protein 1 3 4
  • Cyclin D-Binding Myb-Like Protein 2 3
  • HDMTF1 3 4
  • HDMP1 3 4
  • DMP1 3 4
  • Cyclin D Binding Myb-Like Transcription Factor 1 2
  • Cyclin-D-Binding Myb-Like Transcription Factor 1 3
  • DMTF 3
  • MRUL 3

External Ids for DMTF1 Gene

Previous GeneCards Identifiers for DMTF1 Gene

  • GC07P085317
  • GC07P086379
  • GC07P086393
  • GC07P086426
  • GC07P086620
  • GC07P086781
  • GC07P081392

Summaries for DMTF1 Gene

Entrez Gene Summary for DMTF1 Gene

  • This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for DMTF1 Gene

DMTF1 (Cyclin D Binding Myb Like Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is TTF1.

UniProtKB/Swiss-Prot for DMTF1 Gene

  • Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5-CCCG[GT]ATGT-3 (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Gene Wiki entry for DMTF1 Gene

Additional gene information for DMTF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMTF1 Gene

Genomics for DMTF1 Gene

GeneHancer (GH) Regulatory Elements for DMTF1 Gene

Promoters and enhancers for DMTF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I087151 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.5 +0.9 932 4.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 DMTF1 PIR39826 TMEM243 TP53TG1 DBF4 ENSG00000200397 LOC101927420
GH07I087627 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 15.1 +476.3 476272 1.8 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 GLIS2 ZNF143 SP3 RXRA SP5 RUNDC3B DMTF1 SLC25A40 GC07P087616 GC07M087698 ABCB1
GH07I087187 Enhancer 0.7 dbSUPER 26.5 +43.9 43926 17.5 SOX13 PKNOX1 FOXA2 EBF1 BATF ZBTB7B TEAD3 ZNF280A ZNF121 POLR2A DMTF1 TMEM243 ENSG00000200397 TP53TG1 LOC101927420 LOC105375384 GC07P087193
GH07I087331 Enhancer 1 ENCODE 15.2 +179.6 179563 2.6 ATF1 FOXA2 ARNT NCOA2 TCF12 ZNF766 CBX5 GATA2 ATF7 CAVIN1 DMTF1 TP53TG1 CROT LOC101927420 ENSG00000273623 PIR31944
GH07I086933 Enhancer 0.7 FANTOM5 11.5 -218.3 -218252 0.4 ZNF639 ATF1 CAVIN1 L3MBTL2 NR4A1 ZBTB11 E2F5 ZNF644 ZBTB40 GABPA DMTF1 LOC101927420 KIAA1324L TMEM243 ENSG00000200397 GC07M086929 LOC105375382
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DMTF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DMTF1 gene promoter:

Genomic Locations for DMTF1 Gene

Genomic Locations for DMTF1 Gene
chr7:87,152,361-87,196,337
(GRCh38/hg38)
Size:
43,977 bases
Orientation:
Plus strand
chr7:86,781,677-86,825,653
(GRCh37/hg19)

Genomic View for DMTF1 Gene

Genes around DMTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMTF1 Gene

Proteins for DMTF1 Gene

  • Protein details for DMTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y222-DMTF1_HUMAN
    Recommended name:
    Cyclin-D-binding Myb-like transcription factor 1
    Protein Accession:
    Q9Y222
    Secondary Accessions:
    • B2RBE1
    • B4DJS5
    • Q05C48
    • Q59G79
    • Q6IS13
    • Q969T2
    • Q9H2Z2
    • Q9H2Z3

    Protein attributes for DMTF1 Gene

    Size:
    760 amino acids
    Molecular mass:
    84471 Da
    Quaternary structure:
    • Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.
    SequenceCaution:
    • Sequence=BAD92467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMTF1 Gene

    Alternative splice isoforms for DMTF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMTF1 Gene

Post-translational modifications for DMTF1 Gene

  • Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.

No data available for DME Specific Peptides for DMTF1 Gene

Domains & Families for DMTF1 Gene

Gene Families for DMTF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DMTF1 Gene

Suggested Antigen Peptide Sequences for DMTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y222

UniProtKB/Swiss-Prot:

DMTF1_HUMAN :
  • Belongs to the DMTF1 family.
Family:
  • Belongs to the DMTF1 family.
genes like me logo Genes that share domains with DMTF1: view

Function for DMTF1 Gene

Molecular function for DMTF1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5-CCCG[GT]ATGT-3 (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Phenotypes From GWAS Catalog for DMTF1 Gene

Gene Ontology (GO) - Molecular Function for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 10095122
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with DMTF1: view
genes like me logo Genes that share phenotypes with DMTF1: view

Animal Models for DMTF1 Gene

MGI Knock Outs for DMTF1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DMTF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMTF1 Gene

Localization for DMTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMTF1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,NAS 10095122
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DMTF1: view

Pathways & Interactions for DMTF1 Gene

genes like me logo Genes that share pathways with DMTF1: view

Pathways by source for DMTF1 Gene

1 GeneTex pathway for DMTF1 Gene

Gene Ontology (GO) - Biological Process for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10095122
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0007049 cell cycle IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with DMTF1: view

No data available for SIGNOR curated interactions for DMTF1 Gene

Drugs & Compounds for DMTF1 Gene

No Compound Related Data Available

Transcripts for DMTF1 Gene

Unigene Clusters for DMTF1 Gene

Cyclin D binding myb-like transcription factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DMTF1

Alternative Splicing Database (ASD) splice patterns (SP) for DMTF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a ·
SP1:
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13:
SP14: - - - -
SP15: - - - - -
SP16: - - -
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21: - - - -
SP22:

Relevant External Links for DMTF1 Gene

GeneLoc Exon Structure for
DMTF1
ECgene alternative splicing isoforms for
DMTF1

Expression for DMTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMTF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DMTF1 Gene:

DMTF1

SOURCE GeneReport for Unigene cluster for DMTF1 Gene:

Hs.196129

mRNA Expression by UniProt/SwissProt for DMTF1 Gene:

Q9Y222-DMTF1_HUMAN
Tissue specificity: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.

Evidence on tissue expression from TISSUES for DMTF1 Gene

  • Nervous system(4.9)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with DMTF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMTF1 Gene

Orthologs for DMTF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DMTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMTF1 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia DMTF1 33 34
  • 94.64 (n)
cow
(Bos Taurus)
Mammalia DMTF1 33 34
  • 93.76 (n)
oppossum
(Monodelphis domestica)
Mammalia DMTF1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmtf1 33 16 34
  • 91.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DMTF1 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DMTF1 33 34
  • 80.81 (n)
lizard
(Anolis carolinensis)
Reptilia DMTF1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmtf1 33
  • 69.28 (n)
zebrafish
(Danio rerio)
Actinopterygii dmtf1 33 34
  • 67.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSI1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for DMTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DMTF1 Gene

ENSEMBL:
Gene Tree for DMTF1 (if available)
TreeFam:
Gene Tree for DMTF1 (if available)

Paralogs for DMTF1 Gene

Paralogs for DMTF1 Gene

genes like me logo Genes that share paralogs with DMTF1: view

Variants for DMTF1 Gene

Sequence variations from dbSNP and Humsavar for DMTF1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000017535 -- 87,175,212(+) G/A intron_variant
rs1000018308 -- 87,169,161(+) A/G intron_variant
rs1000132908 -- 87,176,284(+) C/G intron_variant
rs1000134646 -- 87,167,524(+) A/G intron_variant
rs1000164273 -- 87,152,086(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DMTF1 Gene

Variant ID Type Subtype PubMed ID
esv3373567 CNV insertion 20981092
nsv1016761 CNV gain 25217958
nsv483124 CNV gain 15286789
nsv527889 CNV gain 19592680

Variation tolerance for DMTF1 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DMTF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMTF1 Gene

Disorders for DMTF1 Gene

Additional Disease Information for DMTF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DMTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMTF1 Gene

Publications for DMTF1 Gene

  1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). (PMID: 10095122) Bodner SM … Look AT (Gene 1999) 2 3 4 22 58
  2. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (PMID: 17936562) Mallakin A … Inoue K (Cancer cell 2007) 3 4 22 58
  3. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. (PMID: 12917399) Tschan MP … Torbett BE (The Journal of biological chemistry 2003) 3 4 22 58
  4. Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. (PMID: 24958102) Wang Y … Fan D (Molecular and cellular biology 2014) 2 3 58
  5. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. (PMID: 20351715) Liu Y … Wellcome Trust Case-Control Consortium (Molecular psychiatry 2011) 3 44 58

Products for DMTF1 Gene

Sources for DMTF1 Gene

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