Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DMTF1 Gene

protein-coding   GIFtS: 59
GCID: GC07P086781

Cyclin D Binding Myb-Like Transcription Factor 1

  See DMTF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin D Binding Myb-Like Transcription Factor 11 2     hDMP12 3
DMP12 3 5     hDMTF12 3
Cyclin D-Binding Myb-Like Protein1 2     DMTF2
Cyclin-D-Interacting Myb-Like Protein 12 3     Cyclin-D-Binding Myb-Like Transcription Factor 12

External Ids:    HGNC: 146031   Entrez Gene: 99882   Ensembl: ENSG000001351647   OMIM: 6084915   UniProtKB: Q9Y2223   

Export aliases for DMTF1 gene to outside databases

Previous GC identifers: GC07P085317 GC07P086379 GC07P086393 GC07P086426 GC07P086620 GC07P081392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DMTF1 Gene:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats,
and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the
oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and
thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of
aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this
protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human
non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec
2008)

GeneCards Summary for DMTF1 Gene:
DMTF1 (cyclin D binding myb-like transcription factor 1) is a protein-coding gene. Diseases associated with DMTF1 include dental fluorosis, and lung cancer. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TTF1.

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby
promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'
(By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may
antagonize transcriptional activation by isoform 1

Gene Wiki entry for DMTF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMTF1 gene promoter:
         Pax-5   NRF-2   p53   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): DMTF1 promoter sequence
   Search Chromatin IP Primers for DMTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21

DMTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMTF1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086781:  view genomic region     (about GC identifiers)

Start:
86,781,677 bp from pter      End:
86,825,653 bp from pter
Size:
43,977 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,113,189-86,157,158     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222 (See protein sequence)
Recommended Name: Cyclin-D-binding Myb-like transcription factor 1  
Size: 760 amino acids; 84471 Da
Subunit: Interacts with the D-type cyclins CCND1, CCND2 and CCND3 (By similarity). Interaction with D-type cyclins
may modulate transcriptional activation by this protein (By similarity)
Developmental stage: Isoform 2 expression is down-regulated during myeloid differentiation, while the expression
of isoform 1 and isoform 3 remain constant
Sequence caution: Sequence=BAD92467.1; Type=Erroneous translation; Note=Wrong choice of frame;
1 PDB 3D structure from and Proteopedia for DMTF1:
2LLK (3D)    
Secondary accessions: B2RBE1 B4DJS5 Q05C48 Q59G79 Q6IS13 Q969T2 Q9H2Z2 Q9H2Z3
Alternative splicing: 5 isoforms:  Q9Y222-1   Q9Y222-2   Q9Y222-3   Q9Y222-4   Q9Y222-5   

Explore the universe of human proteins at neXtProt for DMTF1: NX_Q9Y222

Explore proteomics data for DMTF1 at MOPED

Post-translational modifications: 

  • Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the
    cyclin-D1/CDK4 complex (By similarity)1
  • Modification sites at neXtProt

  • See DMTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135798.1  NP_001135799.1  NP_066968.3  

    ENSEMBL proteins: 
     ENSP00000332171   ENSP00000402627   ENSP00000389774   ENSP00000464596   ENSP00000401129  
     ENSP00000411908   ENSP00000406384   ENSP00000411858   ENSP00000448775   ENSP00000463638  
     ENSP00000397490   ENSP00000413118   ENSP00000412734   ENSP00000387712   ENSP00000416307  
     ENSP00000412532   ENSP00000464092   ENSP00000415382   ENSP00000413722   ENSP00000378193  
     ENSP00000463735   ENSP00000393370   ENSP00000461920   ENSP00000407941   ENSP00000416499  
     ENSP00000410288   ENSP00000463239   ENSP00000378192   ENSP00000396570   ENSP00000415910  

    DMTF1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DMTF1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DMTF1
    GenScript Custom Purified and Recombinant Proteins Services for DMTF1
    Novus Biologicals DMTF1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DMTF1

     
    Search eBioscience for Proteins for DMTF1 

    DMTF1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DMTF1
    Novus Biologicals DMTF1 Antibodies
    Abcam antibodies for DMTF1
    Cloud-Clone Corp. Antibodies for DMTF1
    ThermoFisher Antibodies for DMTF1
    LSBio Antibodies in human, mouse, rat for DMTF1

    DMTF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DMTF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DMTF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DMTF1
    Cloud-Clone Corp. CLIAs for DMTF1
    Search eBioscience for ELISAs for DMTF1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR017930 Myb_dom
     IPR017877 Myb-like_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9Y222

    ProtoNet protein and cluster: Q9Y222

    UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
    Similarity: Belongs to the DMTF1 family
    Similarity: Contains 1 HTH myb-type DNA-binding domain
    Similarity: Contains 2 Myb-like domains


    Find genes that share domains with DMTF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMTF1_HUMAN, Q9Y222
    Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby
    promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'
    (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may
    antagonize transcriptional activation by isoform 1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10095122
         
    Find genes that share ontologies with DMTF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DMTF1:
     Enable proliferation in B-Raf  

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dmtf1):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     integument  mortality/aging  nervous system  renal/urinary system  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with DMTF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dmtf1tm1Cjs for DMTF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMTF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DMTF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMTF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMTF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DMTF1:
    hsa-mir-15a-5p (MIRT002946), hsa-mir-21-5p (MIRT030806), hsa-mir-16-5p (MIRT031727), hsa-mir-103a-3p (MIRT027072)

    Block miRNA regulation of human, mouse, rat DMTF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMTF1 (see all 49):
    hsa-miR-549 hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-372 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDMTF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DMTF1
    Predesigned siRNA for gene silencing in human, mouse, rat DMTF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DMTF1

    Clone
    Products:
         
    OriGene clones in human, mouse for DMTF1 (see all 19)
    OriGene ORF clones in mouse, rat for DMTF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DMTF1 (NM_021145)
    Sino Biological Human cDNA Clone for DMTF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMTF1
    Addgene plasmids for DMTF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DMTF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DMTF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMTF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DMTF1_HUMAN, Q9Y222: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10095122
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with DMTF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DMTF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated transcriptional targets of AP1 family members Fra1 and Fra2
    Validated transcriptional targets of AP1 family members Fra1 and Fra2


    1 BioSystems Pathway for DMTF1
        Validated transcriptional targets of AP1 family members Fra1 and Fra2



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMTF1
    Interactions:

        Search GeneGlobe Interaction Network for DMTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DMTF1 (Q9Y2222, 3 ENSP000003321714) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61915 I2D: score=3 
    CCND3P302813, ENSP000003620824I2D: score=2 STRING: ENSP00000362082
    CCND1P243853, ENSP000002275074I2D: score=2 STRING: ENSP00000227507
    CCND2P302793, ENSP000002612544I2D: score=2 STRING: ENSP00000261254
    JUNENSP000003602664STRING: ENSP00000360266
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS10095122
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with DMTF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMTF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DMTF1 gene (3 alternative transcripts): 
    NM_001142326.1  NM_001142327.1  NM_021145.3  

    Unigene Cluster for DMTF1:

    Cyclin D binding myb-like transcription factor 1
    Hs.196129  [show with all ESTs]
    Unigene Representative Sequence: AK126664
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):
    ENST00000331242(uc003uih.3 uc011khb.2) ENST00000413276 ENST00000447863(uc003uii.3)
    ENST00000579677(uc003uij.3) ENST00000446796 ENST00000425406(uc003uik.3)
    ENST00000420131 ENST00000414630 ENST00000547146 ENST00000579850 ENST00000453049
    ENST00000428819 ENST00000448598 ENST00000449088 ENST00000430405 ENST00000432937
    ENST00000584619 ENST00000432366
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DMTF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMTF1 (see all 49):
    hsa-miR-549 hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-372 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDMTF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DMTF1
    Predesigned siRNA for gene silencing in human, mouse, rat DMTF1
    Clone
    Products:
         
    OriGene clones in human, mouse for DMTF1 (see all 19)
    OriGene ORF clones in mouse, rat for DMTF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DMTF1 (NM_021145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMTF1
    Addgene plasmids for DMTF1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DMTF1
    OriGene qSTAR qPCR primer pairs in human, mouse for DMTF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMTF1
      QuantiTect SYBR Green Assays in human, mouse, rat DMTF1
      QuantiFast Probe-based Assays in human, mouse, rat DMTF1

    Additional mRNA sequence: 

    AB209230.1 AF052102.1 AF084530.1 AF202144.1 AF202145.1 AK002073.1 AK057917.1 AK095828.1 
    AK123259.1 AK126664.1 AK295144.1 AK296211.1 AK314622.1 BC007418.2 BC007447.2 BC029370.1 
    BC070064.1 NR_024549.1 NR_024550.1 

    Selected DOTS entries (see all 28):

    DT.87015777  DT.87013858  DT.92438795  DT.436161  DT.92438790  DT.65284162  DT.95166826  DT.102843239 
    DT.407666  DT.100822911  DT.100822916  DT.40274110  DT.121059998  DT.102843241  DT.121060067  DT.121059967 
    DT.121060054  DT.100822904  DT.121059994  DT.407668  DT.422392  DT.100725113  DT.100822910  DT.121060050 

    Selected AceView cDNA sequences (see all 224):

    AI685126 AW129614 BM722130 BF057846 AF202145 AA489019 AA765137 AA251625 
    AA405066 AI538206 AI337593 BC070064 BX281436 AU138152 AA906948 AL040906 
    NM_021145 BQ224002 BX643409 BE205814 BI753203 AF052102 AF202144 AW027430 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DMTF1 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a ·
    SP1:                                                                                                                                                            
    SP2:                    -     -     -     -     -     -     -                 -                                                                                 
    SP3:                    -     -     -     -     -     -     -                                                                                                   
    SP4:                    -                 -     -     -     -                 -                                                                                 
    SP5:                    -     -           -     -     -     -                 -                                                                                 

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b
    SP1:                    -     -                                                                                                               
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for DMTF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DMTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATTTATT
    DMTF1 Expression
    About this image


    DMTF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    DMTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMTF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.196129

    UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222
    Tissue specificity: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate
    and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the
    brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic
    nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most
    strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed
    at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas
    (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor
    suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci.
    Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long
    arm of chromosome 7

        Custom PCR Arrays for DMTF1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DMTF1
    OriGene qSTAR qPCR primer pairs in human, mouse for DMTF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMTF1
    QuantiTect SYBR Green Assays in human, mouse, rat DMTF1
    QuantiFast Probe-based Assays in human, mouse, rat DMTF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMTF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DMTF1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmtf11 , 5 cyclin D binding myb-like transcription factor 11, 5 91.84(n)1
    95.26(a)1
      5 (3.69 cM)5
    238571  NM_011806.31  NP_035936.31 
     91188015 
    chicken
    (Gallus gallus)
    Aves DMTF11 cyclin D binding myb-like transcription factor 1 80.81(n)
    88.54(a)
      418646  NM_001080863.2  NP_001074332.2 
    lizard
    (Anolis carolinensis)
    Reptilia DMTF16
    cyclin D binding myb-like transcription factor 1
    83(a)
    1 ↔ 1
    GL343559.1(367876-407360)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dmtf11 cyclin D binding myb-like transcription factor 1 69.28(n)
    70.58(a)
      100493762  XM_002935253.2  XP_002935299.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dmtf11 cyclin D binding myb-like transcription factor 1 67.34(n)
    73.08(a)
      436938  NM_001002665.1  NP_001002665.1 


    ENSEMBL Gene Tree for DMTF1 (if available)
    TreeFam Gene Tree for DMTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DMTF1 gene
    TTF12  

    Find genes that share paralogs with DMTF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DMTF1 (see all 939)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394997961,2
    C--86112560(+) TTTAA-/TATACG 5 -- us2k10--------
    rs1126945481,2
    C--86120236(+) CCAAT-/AGA   
      G
    /GAGA
    AGAAT
    5 -- int11CSA 2
    rs723766561,2
    C--86120237(+) CAATA-/AGAG  
            
    GAATT
    5 -- int10--------
    rs166271,2
    C,F--86120239(-) AAAATTCTC/-  
            
    TCTAT
    5 -- int14Minor allele frequency- -:0.29EU NA EA 342
    rs1927311161,2
    --86124059(+) TTTTTC/TTTTTC 5 -- int10--------
    rs58855751,2
    C--86135175(+) GTAATA/-TTTTT 5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs339398851,2
    C--86135176(+) TAATT-/ATTTTT 5 -- int10--------
    rs1443973191,2
    C--86135504(+) TATGG-/GCATAT 5 -- int10--------
    rs1471841701,2
    C--86151984(+) GACTT-/CTACTTTT 5 -- int10--------
    rs114384631,2
    C--86792131(+) CTTTTT/-TTTTT 5 -- int1 trp31Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for DMTF1 (86781677 - 86825653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DMTF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483124CNV Gain15286789
    nsv888677CNV Gain21882294
    nsv527889CNV Gain19592680
    nsv888676CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DMTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for DMTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608491    OMIM disorders: --

    2 diseases for DMTF1:    
    About MalaCards
    dental fluorosis    lung cancer

    1 disease from the University of Copenhagen DISEASES database for DMTF1:
    Dental fluorosis

    Find genes that share disorders with DMTF1           About GenesLikeMe

    1 Novoseek inferred disease relationship for DMTF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 22.3 14 17237816 (3), 19816943 (3), 18598225 (2), 17546045 (1) (see all 7)

    Genetic Association Database (GAD): DMTF1
    Human Genome Epidemiology (HuGE) Navigator: DMTF1 (3 documents)

    Export disorders for DMTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DMTF1 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DMTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). (PubMed id 10095122)1, 2, 3, 9 Bodner S.M.... Look A.T. (Gene 1999)
    2. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (PubMed id 17936562)1, 2, 9 Mallakin A....Inoue K. (Cancer Cell 2007)
    3. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. (PubMed id 12917399)1, 2, 9 Tschan M.P.... Torbett B.E. (J. Biol. Chem. 2003)
    4. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. (PubMed id 20351715)1, 4 Liu Y....Sullivan P.F. (Mol. Psychiatry 2011)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Single nucleotide polymorphisms in breast cancer. (PubMed id 15010895)1, 4 FAPrsti A....Kumar R. (Oncol. Rep. 2004)
    7. Dmp1 and tumor suppression. (PubMed id 17237816)1, 9 Inoue K....Frazier D.P. (Oncogene 2007)
    8. Role of DMP1 and its future in lung cancer diagnostics. (PubMed id 18598225)1, 9 Sugiyama T....Inoue K. (Expert Rev. Mol. Diagn. 2008)
    9. Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer. (PubMed id 23045280)1 Maglic D....Inoue K. (Oncogene 2013)
    10. Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function. (PubMed id 22331460)1 Frazier D.P....Inoue K. (Cancer Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9988 HGNC: 14603 AceView: DMTF1 Ensembl:ENSG00000135164 euGenes: HUgn9988
    ECgene: DMTF1 H-InvDB: DMTF1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DMTF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DMTF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DMTF1 gene:
    Search GeneIP for patents involving DMTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DMTF1  
     OriGene qPCR primer pairs and template standards for DMTF1   OriGene Protein Over-expression Lysate for DMTF1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DMTF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DMTF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DMTF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DMTF1   OriGene Custom Protein Services for DMTF1  

     
     
     Block miRNA regulation of human, mouse, rat DMTF1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DMTF1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMTF1 Predesigned siRNA for gene silencing in human, mouse, rat DMTF1
     QuantiFast Probe-based Assays in human, mouse, rat DMTF1 QuantiTect SYBR Green Assays in human, mouse, rat DMTF1
     Custom PCR Arrays for DMTF1 Search Chromatin IP Primers for DMTF1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMTF1  Search GeneGlobe Interaction Network for DMTF1
     Regulatory tfbs in DMTF1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DMTF1 GenScript cDNA clones with any tag delivered in your preferred vector for DMTF1
     GenScript Custom Assay Services for DMTF1 GenScript Custom overexpressing Cell Line Services for DMTF1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DMTF1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DMTF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DMTF1 antibodies
     DMTF1 proteins
     Antibodies for DMTF1
     See all of Abcam's Antibodies, Kits and Proteins for DMTF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DMTF1
     Antibodies for DMTF1
     ELISAs for DMTF1
     CLIAs for DMTF1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DMTF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMTF1
     SwitchGear 3'UTR luciferase reporter plasmids for DMTF1
     SwitchGear Promoter luciferase reporter plasmids for DMTF1
     ThermoFisher Antibodies for DMTF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMTF1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMTF1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DMTF1
     LSBio Antibodies in human, mouse, rat for DMTF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for DMTF1
      Search eBioscience for proteins for DMTF1
      Search eBioscience for elisas for DMTF1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DMTF1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4