DMRTC2 Gene
protein-coding GIFtS : 43
GCID: GC19 P042349
DMRT-like family C2
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Aliasesfor DMRTC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DMRT-Like Family C2 1 2 Doublesex- And Mab-3-Related Transcription Factor C22
Export aliases for DMRTC2 gene to outside databases Previous GC identifers: GC19P042988 GC19P042740 GC19P047025 GC19P047041 GC19P047043 GC19P047044 GC19P038780
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Summariesfor DMRTC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DMRTD_HUMAN, Q8IXT2 Function : May be involved in sexual development
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Genomic Viewsfor DMRTC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DMRTC2 gene promoter: Egr-3 Max1 GR GR-beta NRSF form 2 PPAR-alpha HEN1 GR-alpha c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for DMRTC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DMRTC2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2 DMRTC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P042349: view genomic region
(about GC identifiers )
Start:
42,349,086 bp from pter
End:
42,356,398 bp from pter
Size:
7,313 bases
Orientation:
plus strand
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Proteinsfor DMRTC2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DMRTD_HUMAN, Q8IXT2 (See
protein sequence )Recommended Name: Doublesex- and mab-3-related transcription factor C2 Size : 367 amino acids; 39124 Da
Subcellular location : Nucleus (Potential)
Secondary accessions : Q8N6Q2 Q96M39 Q96SD4Alternative splicing : 2 isoforms : Q8IXT2-1 Q8IXT2-2 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for DMRTC2: NX_Q8IXT2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IXT2 DMRTC2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001035373.1 ENSEMBL proteins: ENSP00000269945 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
DMRTC2 for ontologies About GeneDecksing DMRTC2 Antibody Products: Assay Products for DMRTC2:
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Protein
Domains / Familiesfor DMRTC2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DMRTC2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IXT2 ProtoNet protein and cluster: Q8IXT2
1 Blocks protein family : IPB001275 DM DNA-binding UniProtKB/Swiss-Prot: DMRTD_HUMAN, Q8IXT2 Similarity : Belongs to the DMRT familySimilarity : Contains 1 DM DNA-binding domain
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Functionfor DMRTC2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DMRTD_HUMAN, Q8IXT2 Function : May be involved in sexual development
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTC2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DMRTC2 (NM_001040283 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTC2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0043565 sequence-specific DNA binding
IEA -- GO:0046872 metal ion binding
IEA --
DMRTC2 for ontologies About GeneDecksing Animal Models: Mouse knock-out Dmrtc2 tm1.2Zark for DMRTC2 4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Dmrtc2) :
DMRTC2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor DMRTC2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMRTC2 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5/6 Interacting proteins for DMRTC2 (Q8IXT2 3 ENSP00000269945 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007548 sex differentiation
IEA -- GO:0030154 cell differentiation
IEA --
DMRTC2 for ontologies About GeneDecksing
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Drugs & Compoundsfor DMRTC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DMRTC2 Search CenterWatch for drugs/clinical trials and news about DMRTC2 / DMRTD
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Transcriptsfor DMRTC2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DMRTC2 gene (2 alternative transcripts): NM_033052.1 NM_001040283.1 Unigene Cluster for DMRTC2:
DMRT-like family C2 Hs.350507 [show with all ESTs ] Unigene Representative Sequence: NM_001040283 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000269945 (uc002orr.1 uc002ors.3 uc010xwe.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTC2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DMRTC2 (NM_001040283 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTC2
Additional cDNA sequence: AJ291669.1 AK301822.1 BC029202.1 BC039266.1
5 DOTS entries : DT.97789552 DT.121419772
DT.121419773 DT.40127844 DT.95157651 24 AceView cDNA sequences :
AW340297 AJ291669 BM553150 AW236959 AI990612 NM_033052 BC029202 BX095905 BM559969 AI126267 AK057404 BC039266 BI829184 AA993932 BE503694 BI562118 AI651482 AW593555 AL449525 BI828716 AW340200 AL449522 AL449524 AL449523 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC2 (see all 7 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b SP1 :         -   -   -           -             -           SP2 :     -   -   -   -   -                       -           SP3 :     -   -   -   -   -           -                       SP4 :         -   -   -                                 SP5 :           -                                  
ECgene alternative splicing isoforms for DMRTC2
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Expression for DMRTC2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DMRTC2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image See DMRTC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DMRTC2 SOURCE GeneReport for Unigene cluster: Hs.350507 UniProtKB/Swiss-Prot: DMRTD_HUMAN, Q8IXT2 Tissue specificity : Expressed in testis and pancreas SABiosciences Custom PCR Arrays for DMRTC2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DMRTC2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DMRTC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DMRTC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DMRTC2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC2
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Orthologsfor DMRTC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for DMRTC2 gene from 3/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for DMRTC2 (if available)TreeFam Gene Tree for DMRTC2 (if available)
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Paralogsfor DMRTC2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DMRTC2 gene DMRTC1 2 DMRTC1B 2 1 SIMAP similar gene for DMRTC2 using alignment to 5 protein entries: DMRTD_HUMAN (see all proteins ):DMRT2
DMRTC2 for paralogs About GeneDecksing
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Genomic Variantsfor DMRTC2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DMRTC2 (42349086 - 42356398 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DMRTC2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DMRTC2
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Disorders
/ Diseasesfor DMRTC2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DMRTC2 for disorders About GeneDecksing
OMIM gene information: 614806
OMIM disorders : --1 disease for DMRTC2 : About MalaCards neuronitis Export disorders for DMRTC2 gene to outside databases
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Publicationsfor DMRTC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DMRTC2 gene integrated from 9 sources : (articles sorted by number of sources associating them with DMRTC2) Utopia : connect your pdf to the dynamic world of online information
Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PubMed id 11863363) 1 , 2 , 3 Ottolenghi C.... McElreavey K. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142) 1 Ravasi T....Hayashizaki Y. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DMRTC2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DMRTC2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DMRTC2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DMRTC2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DMRTC2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DMRTC2 gene: Search GeneIP for patents involving DMRTC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DMRTC2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DMRTC2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DMRTC2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DMRTC2 OriGene Protein Over-expression Lysate for DMRTC2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DMRTC2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTC2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTC2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DMRTC2 OriGene Custom Protein Services for DMRTC2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMRTC2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DMRTC2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DMRTC2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DMRTC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DMRTC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DMRTC2
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DMRTC2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTC2
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