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Aliases for DMRTC2 Gene

Aliases for DMRTC2 Gene

  • DMRT Like Family C2 2 3
  • DMRT-Like Family C2 2 5

External Ids for DMRTC2 Gene

Previous GeneCards Identifiers for DMRTC2 Gene

  • GC19P042988
  • GC19P042740
  • GC19P047025
  • GC19P047041
  • GC19P047043
  • GC19P047044
  • GC19P042349
  • GC19P038780

Summaries for DMRTC2 Gene

GeneCards Summary for DMRTC2 Gene

DMRTC2 (DMRT Like Family C2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRTC1B.

UniProtKB/Swiss-Prot for DMRTC2 Gene

  • May be involved in sexual development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTC2 Gene

Genomics for DMRTC2 Gene

Regulatory Elements for DMRTC2 Gene

Enhancers for DMRTC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DMRTC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DMRTC2 Gene

41,844,743 bp from pter
41,852,333 bp from pter
7,591 bases
Plus strand

Genomic View for DMRTC2 Gene

Genes around DMRTC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC2 Gene

Proteins for DMRTC2 Gene

  • Protein details for DMRTC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublesex- and mab-3-related transcription factor C2
    Protein Accession:
    Secondary Accessions:
    • Q8N6Q2
    • Q96M39
    • Q96SD4

    Protein attributes for DMRTC2 Gene

    367 amino acids
    Molecular mass:
    39124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC2 Gene


neXtProt entry for DMRTC2 Gene

Proteomics data for DMRTC2 Gene at MOPED

Post-translational modifications for DMRTC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTC2 Gene

No data available for DME Specific Peptides for DMRTC2 Gene

Domains & Families for DMRTC2 Gene

Protein Domains for DMRTC2 Gene

Suggested Antigen Peptide Sequences for DMRTC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DM DNA-binding domain.
  • Belongs to the DMRT family.
  • Contains 1 DM DNA-binding domain.
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTC2: view

No data available for Gene Families for DMRTC2 Gene

Function for DMRTC2 Gene

Molecular function for DMRTC2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sexual development.

Gene Ontology (GO) - Molecular Function for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA,IBA --
genes like me logo Genes that share ontologies with DMRTC2: view
genes like me logo Genes that share phenotypes with DMRTC2: view

Animal Models for DMRTC2 Gene

MGI Knock Outs for DMRTC2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DMRTC2 Gene

Localization for DMRTC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTC2 Gene

Subcellular locations from

Jensen Localization Image for DMRTC2 Gene COMPARTMENTS Subcellular localization image for DMRTC2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DMRTC2 Gene

Pathways & Interactions for DMRTC2 Gene

SuperPathways for DMRTC2 Gene

No Data Available

Interacting Proteins for DMRTC2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000269945 Q8IXT2-DMRTD_HUMAN for DMRTC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007141 male meiosis I IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DMRTC2: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTC2 Gene

Drugs & Compounds for DMRTC2 Gene

No Compound Related Data Available

Transcripts for DMRTC2 Gene

Unigene Clusters for DMRTC2 Gene

DMRT-like family C2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for DMRTC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DMRTC2 Gene

mRNA expression in normal human tissues for DMRTC2 Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC2 Gene

This gene is overexpressed in Testis (x51.4).

Protein differential expression in normal tissues from HIPED for DMRTC2 Gene

This gene is overexpressed in Testis (54.1) and Fetal ovary (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMRTC2 Gene

SOURCE GeneReport for Unigene cluster for DMRTC2 Gene Hs.350507

mRNA Expression by UniProt/SwissProt for DMRTC2 Gene

Tissue specificity: Expressed in testis and pancreas.
genes like me logo Genes that share expression patterns with DMRTC2: view

Protein tissue co-expression partners for DMRTC2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DMRTC2 Gene

Orthologs for DMRTC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMRTC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DMRTC2 35
  • 85.79 (n)
  • 81.15 (a)
  • 80 (a)
(Canis familiaris)
Mammalia DMRTC2 35
  • 85.47 (n)
  • 80.38 (a)
  • 78 (a)
(Mus musculus)
Mammalia Dmrtc2 35
  • 85.47 (n)
  • 81.2 (a)
Dmrtc2 16
Dmrtc2 36
  • 80 (a)
(Pan troglodytes)
Mammalia DMRTC2 35
  • 99.55 (n)
  • 98.91 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
Species with no ortholog for DMRTC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMRTC2 Gene

Gene Tree for DMRTC2 (if available)
Gene Tree for DMRTC2 (if available)

Paralogs for DMRTC2 Gene

Paralogs for DMRTC2 Gene

(1) SIMAP similar genes for DMRTC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMRTC2: view

Variants for DMRTC2 Gene

Sequence variations from dbSNP and Humsavar for DMRTC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8100845 -- 41,849,898(+) actga(G/T)cgaga intron-variant
rs17853910 -- 41,848,898(+) GCCTC(A/C)AGGCT reference, synonymous-codon, missense
rs1195088 -- 41,846,898(+) Gggac(A/G)ggtgc intron-variant, upstream-variant-2KB
rs139892036 -- 41,851,280(+) CTGAT(A/G)GTGGA intron-variant
rs140189759 -- 41,848,524(+) CCCCG(A/G)GAAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DMRTC2 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3882n71 CNV Loss 21882294

Variation tolerance for DMRTC2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DMRTC2 Gene

Disorders for DMRTC2 Gene

Relevant External Links for DMRTC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DMRTC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTC2 Gene

Publications for DMRTC2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 2 3 4 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DMRTC2 Gene

Sources for DMRTC2 Gene