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Aliases for DMRTC2 Gene

Aliases for DMRTC2 Gene

  • DMRT-Like Family C2 2 3

External Ids for DMRTC2 Gene

Summaries for DMRTC2 Gene

GeneCards Summary for DMRTC2 Gene

DMRTC2 (DMRT-Like Family C2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DMRTC1B.

UniProtKB/Swiss-Prot for DMRTC2 Gene

  • May be involved in sexual development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTC2 Gene

Genomics for DMRTC2 Gene

Genomic Location for DMRTC2 Gene

Start:
41,844,743 bp from pter
End:
41,852,333 bp from pter
Size:
7,591 bases
Orientation:
Plus strand

Genomic View for DMRTC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMRTC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC2 Gene

Regulatory Elements for DMRTC2 Gene

Proteins for DMRTC2 Gene

  • Protein details for DMRTC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXT2-DMRTD_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor C2
    Protein Accession:
    Q8IXT2
    Secondary Accessions:
    • Q8N6Q2
    • Q96M39
    • Q96SD4

    Protein attributes for DMRTC2 Gene

    Size:
    367 amino acids
    Molecular mass:
    39124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMRTC2 Gene

Proteomics data for DMRTC2 Gene at MOPED

Post-translational modifications for DMRTC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTC2 Gene

No data available for DME Specific Peptides for DMRTC2 Gene

Domains for DMRTC2 Gene

Protein Domains for DMRTC2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

DMRTD_HUMAN
Domain:
  • Contains 1 DM DNA-binding domain.:
    • Q8IXT2
Family:
  • Belongs to the DMRT family.:
    • Q8IXT2
genes like me logo Genes that share domains with DMRTC2: view

No data available for Gene Families for DMRTC2 Gene

Function for DMRTC2 Gene

Molecular function for DMRTC2 Gene

UniProtKB/Swiss-Prot Function: May be involved in sexual development.

Gene Ontology (GO) - Molecular Function for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0042803 protein homodimerization activity IBA --
GO:0043565 sequence-specific DNA binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DMRTC2: view
genes like me logo Genes that share phenotypes with DMRTC2: view

Animal Models for DMRTC2 Gene

MGI Knock Outs for DMRTC2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DMRTC2 Gene

Localization for DMRTC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRTC2 Gene COMPARTMENTS Subcellular localization image for DMRTC2 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DMRTC2: view

Pathways for DMRTC2 Gene

SuperPathways for DMRTC2 Gene

No Data Available

Interacting Proteins for DMRTC2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269945%0d%0a9606.ENSP00000380073%0d%0a9606.ENSP00000314343%0d%0a9606.ENSP00000434516%0d%0a
Selected Interacting proteins: Q8IXT2-DMRTD_HUMAN ENSP00000269945 for DMRTC2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007141 male meiosis I IEA --
GO:0007290 spermatid nucleus elongation IEA --
GO:0007548 sex differentiation IBA --
genes like me logo Genes that share ontologies with DMRTC2: view

No data available for Pathways by source for DMRTC2 Gene

Transcripts for DMRTC2 Gene

Unigene Clusters for DMRTC2 Gene

DMRT-like family C2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:

Relevant External Links for DMRTC2 Gene

GeneLoc Exon Structure for
DMRTC2
ECgene alternative splicing isoforms for
DMRTC2

Expression for DMRTC2 Gene

mRNA expression in normal human tissues for DMRTC2 Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC2 Gene

This gene is overexpressed in Testis (51.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMRTC2 Gene

SOURCE GeneReport for Unigene cluster for DMRTC2 Gene Hs.350507

mRNA Expression by UniProt/SwissProt for DMRTC2 Gene

Q8IXT2-DMRTD_HUMAN
Tissue specificity: Expressed in testis and pancreas.
genes like me logo Genes that share expressions with DMRTC2: view

Orthologs for DMRTC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMRTC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMRTC2 36
  • 99.55 (n)
  • 98.91 (a)
DMRTC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMRTC2 36
  • 85.79 (n)
  • 81.15 (a)
DMRTC2 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMRTC2 36
  • 85.47 (n)
  • 80.38 (a)
DMRTC2 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmrtc2 36
  • 85.47 (n)
  • 81.2 (a)
Dmrtc2 16
Dmrtc2 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
OneToMany
Species with no ortholog for DMRTC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMRTC2 Gene

ENSEMBL:
Gene Tree for DMRTC2 (if available)
TreeFam:
Gene Tree for DMRTC2 (if available)

Paralogs for DMRTC2 Gene

Paralogs for DMRTC2 Gene

Selected SIMAP similar genes for DMRTC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMRTC2: view

Variants for DMRTC2 Gene

Sequence variations from dbSNP and Humsavar for DMRTC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1195088 -- 41,846,898(+) Gggac(A/G)ggtgc intron-variant, upstream-variant-2KB
rs2305809 -- 41,850,561(-) GAGGG(A/G)CCAGA reference, synonymous-codon, utr-variant-3-prime
rs3826704 -- 41,852,033(-) CATGG(A/G)ATCCT utr-variant-3-prime
rs7253640 -- 41,848,535(+) TAAGG(A/C)GAGGC intron-variant
rs8100845 -- 41,849,898(+) actga(G/T)cgaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTC2 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3882n71 CNV Loss 21882294

Relevant External Links for DMRTC2 Gene

HapMap Linkage Disequilibrium report
DMRTC2

Disorders for DMRTC2 Gene

No disorders were found for DMRTC2 Gene.

No data available for UniProtKB/Swiss-Prot for DMRTC2 Gene

Publications for DMRTC2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for DMRTC2 Gene

Sources for DMRTC2 Gene

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