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Aliases for DMRTC2 Gene

Aliases for DMRTC2 Gene

  • DMRT Like Family C2 2 3 5
  • DMRT-Like Family C2 2

External Ids for DMRTC2 Gene

Previous GeneCards Identifiers for DMRTC2 Gene

  • GC19P042988
  • GC19P042740
  • GC19P047025
  • GC19P047041
  • GC19P047043
  • GC19P047044
  • GC19P042349
  • GC19P038780

Summaries for DMRTC2 Gene

GeneCards Summary for DMRTC2 Gene

DMRTC2 (DMRT Like Family C2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRTC1.

UniProtKB/Swiss-Prot for DMRTC2 Gene

  • May be involved in sexual development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTC2 Gene

Genomics for DMRTC2 Gene

Regulatory Elements for DMRTC2 Gene

Enhancers for DMRTC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G041800 1.5 FANTOM5 Ensembl ENCODE dbSUPER 25.1 -42.8 -42781 2.3 HDAC1 CTCF PKNOX1 YY2 KLF17 ZIC2 HIC1 ZFHX2 RAD51 ZBTB33 CEACAM3 CEACAM4 DMRTC2 DEDD2 LYPD4 CEACAM6 CEACAM21 TMEM91 B9D2 TGFB1
GH19G041810 0.9 Ensembl ENCODE 26 -33.8 -33843 1.8 CTCF MAZ MIER1 ZNF398 REST EBF1 BCL11B GLIS2 ZNF366 HDAC2 DMRTC2 LYPD4 GC19P041806 HNRNPA1P52
GH19G041798 1.7 FANTOM5 Ensembl dbSUPER 11.7 -46.3 -46272 2.5 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF574 CEACAM4 CEACAM3 ZNF526 DEDD2 CCDC97 DMRTC2 LYPD4 CEACAM6 TMEM91
GH19G042267 1.9 FANTOM5 ENCODE dbSUPER 9.9 +426.1 426145 6.9 MLX CREB3L1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ZNF526 DEDD2 MEGF8 CEACAM3 CIC PAFAH1B3 PRR19 GSK3A ZNF574 TMEM145
GH19G041791 0.9 dbSUPER 17 -52.1 -52146 2.4 HDGF ATF1 ARID4B SIN3A ZNF2 GLIS2 ZNF143 ZNF263 PAF1 REST DMRTC2 LYPD4 CEACAM6 CEACAM5 CEACAM7 CEACAM3 ENSG00000268833
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DMRTC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DMRTC2 Gene

Chromosome:
19
Start:
41,844,743 bp from pter
End:
41,852,333 bp from pter
Size:
7,591 bases
Orientation:
Plus strand

Genomic View for DMRTC2 Gene

Genes around DMRTC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC2 Gene

Proteins for DMRTC2 Gene

  • Protein details for DMRTC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXT2-DMRTD_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor C2
    Protein Accession:
    Q8IXT2
    Secondary Accessions:
    • Q8N6Q2
    • Q96M39
    • Q96SD4

    Protein attributes for DMRTC2 Gene

    Size:
    367 amino acids
    Molecular mass:
    39124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMRTC2 Gene

Post-translational modifications for DMRTC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DMRTC2 Gene

Domains & Families for DMRTC2 Gene

Protein Domains for DMRTC2 Gene

Suggested Antigen Peptide Sequences for DMRTC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXT2

UniProtKB/Swiss-Prot:

DMRTD_HUMAN :
  • Belongs to the DMRT family.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTC2: view

No data available for Gene Families for DMRTC2 Gene

Function for DMRTC2 Gene

Molecular function for DMRTC2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sexual development.

Gene Ontology (GO) - Molecular Function for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DMRTC2: view
genes like me logo Genes that share phenotypes with DMRTC2: view

Animal Models for DMRTC2 Gene

MGI Knock Outs for DMRTC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DMRTC2 Gene

Localization for DMRTC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMRTC2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DMRTC2: view

Pathways & Interactions for DMRTC2 Gene

SuperPathways for DMRTC2 Gene

No Data Available

Interacting Proteins for DMRTC2 Gene

Gene Ontology (GO) - Biological Process for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007141 male meiosis I IEA --
GO:0007290 spermatid nucleus elongation IEA --
GO:0007548 sex differentiation IEA --
genes like me logo Genes that share ontologies with DMRTC2: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTC2 Gene

Transcripts for DMRTC2 Gene

Unigene Clusters for DMRTC2 Gene

DMRT-like family C2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:

Relevant External Links for DMRTC2 Gene

GeneLoc Exon Structure for
DMRTC2
ECgene alternative splicing isoforms for
DMRTC2

Expression for DMRTC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMRTC2 Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC2 Gene

This gene is overexpressed in Testis (x51.4).

Protein differential expression in normal tissues from HIPED for DMRTC2 Gene

This gene is overexpressed in Testis (54.1) and Fetal ovary (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DMRTC2 Gene



Protein tissue co-expression partners for DMRTC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DMRTC2 Gene:

DMRTC2

SOURCE GeneReport for Unigene cluster for DMRTC2 Gene:

Hs.350507

mRNA Expression by UniProt/SwissProt for DMRTC2 Gene:

Q8IXT2-DMRTD_HUMAN
Tissue specificity: Expressed in testis and pancreas.

Evidence on tissue expression from TISSUES for DMRTC2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DMRTC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMRTC2 Gene

Orthologs for DMRTC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMRTC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMRTC2 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia DMRTC2 34 35
  • 85.79 (n)
dog
(Canis familiaris)
Mammalia DMRTC2 34 35
  • 85.47 (n)
mouse
(Mus musculus)
Mammalia Dmrtc2 34 16 35
  • 85.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
Species where no ortholog for DMRTC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMRTC2 Gene

ENSEMBL:
Gene Tree for DMRTC2 (if available)
TreeFam:
Gene Tree for DMRTC2 (if available)

Paralogs for DMRTC2 Gene

Paralogs for DMRTC2 Gene

(1) SIMAP similar genes for DMRTC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMRTC2: view

Variants for DMRTC2 Gene

Sequence variations from dbSNP and Humsavar for DMRTC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000189887 -- 41,847,796(+) CAGCT(A/G)AAGAA reference, synonymous-codon, utr-variant-5-prime
rs1000560049 -- 41,845,743(+) AATTG(C/G)TTGAA intron-variant, upstream-variant-2KB
rs1003742123 -- 41,844,359(+) AAGCA(C/T)GGGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1004270385 -- 41,850,172(+) ACAAA(A/G)TAAGT intron-variant
rs1004332060 -- 41,844,100(+) ATTTT(A/T)GAGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DMRTC2 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV gain 19592680

Variation tolerance for DMRTC2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRTC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMRTC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTC2 Gene

Disorders for DMRTC2 Gene

Relevant External Links for DMRTC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRTC2

No disorders were found for DMRTC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTC2 Gene

Publications for DMRTC2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3 64

Products for DMRTC2 Gene

Sources for DMRTC2 Gene

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