DMRTC1B Gene
protein-coding GIFtS: 35
GCID: GC0XP072064
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DMRT-like family C1B
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Aliases
for DMRTC1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DMRT-Like Family C1B1 2 | | DMRT-Like Family C12 | | Doublesex- And Mab-3-Related Transcription Factor C12 |
Export aliases for DMRTC1B gene to outside databasesPrevious GC identifers: GC0XU900857 GC0XP071916 |
Summaries
for DMRTC1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DMRTC1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DMRTC1B gene promoter:
SRF RP58 POU3F1 SRF (504 AA) MIF-1 XBP-1 AP-4 ARP-1 Pax-4a En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DMRTC1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMRTC1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.2 Ensembl cytogenetic band: Xq13.2 HGNC cytogenetic band: Xq13.2DMRTC1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP072064: view genomic region
(about GC identifiers)
Start:
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71,996,833 bp from pter |
End:
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72,068,636 bp from pter |
Size:
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71,804 bases |
Orientation:
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plus strand |
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Proteins
for DMRTC1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DMRTC_HUMAN, Q5HYR2 (See
protein sequence)Recommended Name: Doublesex- and mab-3-related transcription factor C1 Size: 192 amino acids; 20139 Da
Caution: Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain
Secondary accessions: Q5HYR0 Q5U5K2 Q8N6L3 Q96SD3Alternative splicing: 2 isoforms: Q5HYR2-1 Q5HYR2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DMRTC1B: NX_Q5HYR2
DMRTC1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074320.1
ENSEMBL proteins: ENSP00000435159 ENSP00000334501 ENSP00000397859 ENSP00000362633 ENSP00000404476 ENSP00000434020 ENSP00000362632 ENSP00000328296
Human Recombinant Protein Products:
DMRTC1B Antibody Products:
Assay Products for DMRTC1B: |
Protein
Domains /
Families
for DMRTC1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DMRTC1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5HYR2ProtoNet protein and cluster: Q5HYR2 UniProtKB/Swiss-Prot: DMRTC_HUMAN, Q5HYR2Similarity: Belongs to the DMRT family |
Function
for DMRTC1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DMRTC1B (NM_001080851) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTC1B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DMRTC1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC1B |
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Pathways & Interactions
for DMRTC1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMRTC1B
4 Interacting proteins for DMRTC1B (Q5HYR23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
DMRTC1B for ontologies About GeneDecksing
|
Drugs & Compounds
for DMRTC1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DMRTC1B
Search CenterWatch for drugs/clinical trials and news about DMRTC1B / DMRTC
|
Transcripts
for DMRTC1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DMRTC1B gene: NM_001080851.1 Unigene Cluster for DMRTC1B: DMRT-like family C1B Hs.712728 [show with all ESTs]Unigene Representative Sequence: NM_0010808518 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000472595 ENST00000334036 ENST00000440247 ENST00000373533(uc010nlm.3)
ENST00000438696 ENST00000481112 ENST00000373532(uc004ebb.3) ENST00000333826
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DMRTC1B (NM_001080851) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTC1B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DMRTC1B |
8 DOTS entries: DT.100750064 DT.97834977 DT.121291800 DT.121291809 DT.121320444 DT.306314 DT.306315 DT.95297485
GeneLoc Exon Structure
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Expression
for DMRTC1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DMRTC1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DMRTC1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DMRTC1B
SOURCE GeneReport for Unigene cluster: Hs.712728
UniProtKB/Swiss-Prot: DMRTC_HUMAN, Q5HYR2Tissue specificity: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many othertissues
SABiosciences Custom PCR Arrays for DMRTC1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DMRTC1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DMRTC1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRTC1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRTC1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC1B |
Orthologs
for DMRTC1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DMRTC1B gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for DMRTC1B (if available)
TreeFam Gene Tree for DMRTC1B (if available) |
Paralogs
for DMRTC1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DMRTC1B gene
- DMRTC11 2 DMRTC22
1 SIMAP similar gene for DMRTC1B using alignment to 2 protein entries: DMRTC_HUMAN (see all proteins):DMRTC1
DMRTC1B for paralogs About GeneDecksing
|
Genomic Variants
for DMRTC1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DMRTC1B (71996833 - 72068636 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DMRTC1B
2 Inversions: 37388 37387 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DMRTC1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DMRTC1B for disorders About GeneDecksing
1  disease for DMRTC1B: About MalaCardsneuronitis
Export disorders for DMRTC1B gene to outside databases
|
Publications
for DMRTC1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DMRTC1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with DMRTC1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PubMed id 11863363)1, 2 Ottolenghi C.... McElreavey K. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DMRTC1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DMRTC1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DMRTC1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DMRTC1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DMRTC1B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DMRTC1B gene:
Search GeneIP for patents involving DMRTC1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DMRTC1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DMRTC1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DMRTC1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DMRTC1B | | | OriGene Protein Over-expression Lysate for DMRTC1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DMRTC1B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DMRTC1B | | OriGene Custom Protein Services for DMRTC1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMRTC1B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DMRTC1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMRTC1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DMRTC1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRTC1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRTC1B |
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| | | | Search Tocris compounds for DMRTC1B |
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 | | | DMRTC1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC1B |
|  |  |  | | | | Search ThermoFisher Antibodies for DMRTC1B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DMRTC1B |
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