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Aliases for DMRTC1 Gene

Aliases for DMRTC1 Gene

  • DMRT-Like Family C1 2 3
  • Doublesex- And Mab-3-Related Transcription Factor C1 3
  • Doublesex-Mab-3 3
  • DMRTC1 DMRTC1B 4

External Ids for DMRTC1 Gene

Summaries for DMRTC1 Gene

GeneCards Summary for DMRTC1 Gene

DMRTC1 (DMRT-Like Family C1) is a Protein Coding gene. Diseases associated with DMRTC1 include intrahepatic cholangiocarcinoma. An important paralog of this gene is DMRTC1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTC1 Gene

Genomics for DMRTC1 Gene

Genomic Location for DMRTC1 Gene

Start:
72,872,025 bp from pter
End:
72,943,814 bp from pter
Size:
71,790 bases
Orientation:
Minus strand

Genomic View for DMRTC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMRTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC1 Gene

Regulatory Elements for DMRTC1 Gene

Proteins for DMRTC1 Gene

  • Protein details for DMRTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYR2-DMRTC_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor C1
    Protein Accession:
    Q5HYR2
    Secondary Accessions:
    • Q5HYR0
    • Q5U5K2
    • Q8N6L3
    • Q96SD3

    Protein attributes for DMRTC1 Gene

    Size:
    192 amino acids
    Molecular mass:
    20139 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMRTC1 Gene

Proteomics data for DMRTC1 Gene at MOPED

Post-translational modifications for DMRTC1 Gene

No Post-translational modifications

Other Protein References for DMRTC1 Gene

No data available for DME Specific Peptides for DMRTC1 Gene

Domains for DMRTC1 Gene

Protein Domains for DMRTC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DMRTC_HUMAN
Family:
  • Belongs to the DMRT family.:
    • Q5HYR2
genes like me logo Genes that share domains with DMRTC1: view

No data available for Gene Families for DMRTC1 Gene

Function for DMRTC1 Gene

Gene Ontology (GO) - Molecular Function for DMRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with DMRTC1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DMRTC1 Gene

Localization for DMRTC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRTC1 Gene COMPARTMENTS Subcellular localization image for DMRTC1 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DMRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DMRTC1: view

Pathways for DMRTC1 Gene

SuperPathways for DMRTC1 Gene

No Data Available

Interacting Proteins for DMRTC1 Gene

Selected Interacting proteins: Q5HYR2-DMRTC_HUMAN for DMRTC1 Gene via I2D

Gene Ontology (GO) - Biological Process for DMRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007548 sex differentiation IBA --
genes like me logo Genes that share ontologies with DMRTC1: view

No data available for Pathways by source for DMRTC1 Gene

Transcripts for DMRTC1 Gene

mRNA/cDNA for DMRTC1 Gene

Unigene Clusters for DMRTC1 Gene

DMRT-like family C1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC1 Gene

No ASD Table

Relevant External Links for DMRTC1 Gene

GeneLoc Exon Structure for
DMRTC1
ECgene alternative splicing isoforms for
DMRTC1

Expression for DMRTC1 Gene

mRNA expression in normal human tissues for DMRTC1 Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.2), Pituitary (4.8), Brain - Hypothalamus (4.5), Brain - Cortex (4.4), Brain - Frontal Cortex (BA9) (4.3), and Brain - Anterior cingulate cortex (BA24) (4.3).

SOURCE GeneReport for Unigene cluster for DMRTC1 Gene Hs.558685

mRNA Expression by UniProt/SwissProt for DMRTC1 Gene

Q5HYR2-DMRTC_HUMAN
Tissue specificity: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many other tissues.
genes like me logo Genes that share expressions with DMRTC1: view

Orthologs for DMRTC1 Gene

Evolution for DMRTC1 Gene

ENSEMBL:
Gene Tree for DMRTC1 (if available)
TreeFam:
Gene Tree for DMRTC1 (if available)

No data available for Orthologs for DMRTC1 Gene

Paralogs for DMRTC1 Gene

Paralogs for DMRTC1 Gene

Selected SIMAP similar genes for DMRTC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DMRTC1: view

Variants for DMRTC1 Gene

Sequence variations from dbSNP and Humsavar for DMRTC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1009689 -- 72,930,047(-) GAAAA(G/T)GGACC intron-variant
rs5981879 -- 72,892,984(+) TAATA(A/G)CCTAC intron-variant
rs5981900 -- 72,893,864(+) ttcac(A/G)actgc intron-variant
rs6647046 -- 72,881,920(+) GGTGA(C/T)GCTGT intron-variant
rs6647118 -- 72,891,724(+) taaac(A/G)ggcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTC1 Gene

Variant ID Type Subtype PubMed ID
nsv7450 OTHER Inversion 18451855

Relevant External Links for DMRTC1 Gene

HapMap Linkage Disequilibrium report
DMRTC1

Disorders for DMRTC1 Gene

genes like me logo Genes that share disorders with DMRTC1: view

No data available for UniProtKB/Swiss-Prot for DMRTC1 Gene

Publications for DMRTC1 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DMRTC1 Gene

Sources for DMRTC1 Gene

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