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Aliases for DMRTC1 Gene

Aliases for DMRTC1 Gene

  • DMRT Like Family C1 2 3 5
  • Doublesex- And Mab-3-Related Transcription Factor C1 3
  • DMRT-Like Family C1 2
  • Doublesex-Mab-3 3
  • DMRTC1 DMRTC1B 4

External Ids for DMRTC1 Gene

Previous GeneCards Identifiers for DMRTC1 Gene

  • GC0XU990339
  • GC0XM069266
  • GC0XM070306
  • GC0XP070863
  • GC0XP071779
  • GC0XM072008
  • GC0XM072091
  • GC0XP065819

Summaries for DMRTC1 Gene

GeneCards Summary for DMRTC1 Gene

DMRTC1 (DMRT Like Family C1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is DMRTC1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTC1 Gene

Genomics for DMRTC1 Gene

Regulatory Elements for DMRTC1 Gene


Promoters for DMRTC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001917701 314 1400

Genomic Location for DMRTC1 Gene

Chromosome:
X
Start:
72,872,025 bp from pter
End:
72,943,814 bp from pter
Size:
71,790 bases
Orientation:
Minus strand

Genomic View for DMRTC1 Gene

Genes around DMRTC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC1 Gene

Proteins for DMRTC1 Gene

  • Protein details for DMRTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYR2-DMRTC_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor C1
    Protein Accession:
    Q5HYR2
    Secondary Accessions:
    • Q5HYR0
    • Q5U5K2
    • Q8N6L3
    • Q96SD3

    Protein attributes for DMRTC1 Gene

    Size:
    192 amino acids
    Molecular mass:
    20139 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMRTC1 Gene

Post-translational modifications for DMRTC1 Gene

No Post-translational modifications

Other Protein References for DMRTC1 Gene

No data available for DME Specific Peptides for DMRTC1 Gene

Domains & Families for DMRTC1 Gene

Protein Domains for DMRTC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5HYR2

UniProtKB/Swiss-Prot:

DMRTC_HUMAN :
  • Belongs to the DMRT family.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTC1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DMRTC1 Gene

Function for DMRTC1 Gene

Gene Ontology (GO) - Molecular Function for DMRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with DMRTC1: view
genes like me logo Genes that share phenotypes with DMRTC1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DMRTC1 Gene

Localization for DMRTC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRTC1 Gene COMPARTMENTS Subcellular localization image for DMRTC1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DMRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with DMRTC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DMRTC1 Gene

Pathways & Interactions for DMRTC1 Gene

SuperPathways for DMRTC1 Gene

No Data Available

Interacting Proteins for DMRTC1 Gene

Gene Ontology (GO) - Biological Process for DMRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007548 sex differentiation IBA --
genes like me logo Genes that share ontologies with DMRTC1: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTC1 Gene

Transcripts for DMRTC1 Gene

Unigene Clusters for DMRTC1 Gene

DMRT-like family C1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC1 Gene

No ASD Table

Relevant External Links for DMRTC1 Gene

GeneLoc Exon Structure for
DMRTC1
ECgene alternative splicing isoforms for
DMRTC1

Expression for DMRTC1 Gene

mRNA expression in normal human tissues for DMRTC1 Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.2), Pituitary (x4.8), Brain - Hypothalamus (x4.5), Brain - Cortex (x4.4), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Anterior cingulate cortex (BA24) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of DMRTC1 Gene:

DMRTC1

SOURCE GeneReport for Unigene cluster for DMRTC1 Gene:

Hs.558685

mRNA Expression by UniProt/SwissProt for DMRTC1 Gene:

Q5HYR2-DMRTC_HUMAN
Tissue specificity: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many other tissues.
genes like me logo Genes that share expression patterns with DMRTC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DMRTC1 Gene

Orthologs for DMRTC1 Gene

Evolution for DMRTC1 Gene

ENSEMBL:
Gene Tree for DMRTC1 (if available)
TreeFam:
Gene Tree for DMRTC1 (if available)

No data available for Orthologs for DMRTC1 Gene

Paralogs for DMRTC1 Gene

Paralogs for DMRTC1 Gene

(1) SIMAP similar genes for DMRTC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DMRTC1: view

Variants for DMRTC1 Gene

Sequence variations from dbSNP and Humsavar for DMRTC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1009689 -- 72,930,047(-) GAAAA(G/T)GGACC intron-variant
rs1011193 -- 72,915,927(-) TTTAC(C/T)GACCT intron-variant
rs111548960 -- 72,926,302(+) TAAGG(A/G)TACAG intron-variant
rs112059343 -- 72,907,353(+) TATAT(A/T)TAGAC intron-variant
rs112101723 -- 72,892,210(+) ACACA(A/G)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTC1 Gene

Variant ID Type Subtype PubMed ID
esv3574046 CNV loss 25503493
esv3576926 CNV gain 25503493
nsv7450 OTHER inversion 18451855
nsv953429 CNV deletion 24416366

Variation tolerance for DMRTC1 Gene

Gene Damage Index Score: 3.47; 55.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRTC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMRTC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTC1 Gene

Disorders for DMRTC1 Gene

Relevant External Links for DMRTC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRTC1

No disorders were found for DMRTC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTC1 Gene

Publications for DMRTC1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 3 4 64
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for DMRTC1 Gene

Sources for DMRTC1 Gene

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