DMRTC1 Gene
protein-coding GIFtS: 41
GCID: GC0XM072091
|
|
DMRT-like family C1
| |
Aliases
for DMRTC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DMRT-Like Family C11 2 | | Doublesex- And Mab-3-Related Transcription Factor C12 | | Doublesex-Mab-31 |
Export aliases for DMRTC1 gene to outside databasesPrevious GC identifers: GC0XU990339 GC0XM069266 GC0XM070306 GC0XP070863 GC0XP071779 GC0XM072008 GC0XP065819 |
Summaries
for DMRTC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DMRTC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DMRTC1 gene promoter:
SRF GATA-3 POU3F1 SRF (504 AA) ARP-1 CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DMRTC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMRTC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.2 Ensembl cytogenetic band: Xq13.2 HGNC cytogenetic band: Xq13.2DMRTC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM072091: view genomic region
(about GC identifiers)
Start:
|
72,091,859 bp from pter |
End:
|
72,163,653 bp from pter |
Size:
|
71,795 bases |
Orientation:
|
minus strand |
|
Proteins
for DMRTC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DMRTC_HUMAN, Q5HYR2 (See
protein sequence)Recommended Name: Doublesex- and mab-3-related transcription factor C1 Size: 192 amino acids; 20139 Da
Caution: Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain
Secondary accessions: Q5HYR0 Q5U5K2 Q8N6L3 Q96SD3Alternative splicing: 2 isoforms: Q5HYR2-1 Q5HYR2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DMRTC1: NX_Q5HYR2
DMRTC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149042.2
ENSEMBL proteins: ENSP00000433298 ENSP00000362629 ENSP00000362630 ENSP00000290273
Human Recombinant Protein Products for DMRTC1:
DMRTC1 Antibody Products:
Assay Products for DMRTC1: |
Protein
Domains /
Families
for DMRTC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DMRTC1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5HYR2ProtoNet protein and cluster: Q5HYR2 UniProtKB/Swiss-Prot: DMRTC_HUMAN, Q5HYR2Similarity: Belongs to the DMRT family |
Function
for DMRTC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DMRTC1 (NM_033053) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRTC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC1 |
|
Pathways & Interactions
for DMRTC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMRTC1
4 Interacting proteins for DMRTC1 (Q5HYR23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
DMRTC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DMRTC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DMRTC1
Search CenterWatch for drugs/clinical trials and news about DMRTC1 / DMRTC
|
Transcripts
for DMRTC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DMRTC1 gene: NM_033053.2 Unigene Cluster for DMRTC1: DMRT-like family C1 Hs.558685 [show with all ESTs]Unigene Representative Sequence: NM_0330534 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000483816(uc004ebc.3) ENST00000373529 ENST00000373530(uc010nln.3)
ENST00000290273
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DMRTC1 (NM_033053) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRTC1 |
Additional cDNA sequence: BC047596.1 5 DOTS entries: DT.100750064 DT.97834977 DT.306314 DT.306315 DT.95297485 24/42 AceView cDNA sequences (see all 42): BC025725 AA582811 BU679773 BE504226 BC047596 AA017453 BM931824 NM_033053 BC029799 AA058669 AJ291670 AA984461 BM549614 CB121638 AA081642 AV753283 BM683954 BI756447 AA189103 NM_152693 BM980829 AW205069 BC041962 BI769929
GeneLoc Exon Structure
|
Expression
for DMRTC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DMRTC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGATGTTTT
About this image
See DMRTC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DMRTC1
SOURCE GeneReport for Unigene cluster: Hs.558685
UniProtKB/Swiss-Prot: DMRTC_HUMAN, Q5HYR2Tissue specificity: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many othertissues
SABiosciences Custom PCR Arrays for DMRTC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DMRTC1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DMRTC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRTC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRTC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC1 |
Orthologs
for DMRTC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DMRTC1 gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for DMRTC1 (if available)
TreeFam Gene Tree for DMRTC1 (if available) |
Paralogs
for DMRTC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DMRTC1 gene
- DMRTC1B1 2 DMRTC22
1 SIMAP similar gene for DMRTC1 using alignment to 3 protein entries: DMRTC_HUMAN (see all proteins):DMRTC1B
DMRTC1 for paralogs About GeneDecksing
|
Genomic Variants
for DMRTC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DMRTC1 (72091859 - 72163653 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DMRTC1
2 Inversions: 37388 37387 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DMRTC1 |
|
Disorders
/ Diseases
for DMRTC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DMRTC1 for disorders About GeneDecksing
OMIM gene information: 300878
OMIM disorders: --
3  diseases for DMRTC1: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma neuronitis
Export disorders for DMRTC1 gene to outside databases
|
Publications
for DMRTC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DMRTC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DMRTC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PubMed id 11863363)1, 2 Ottolenghi C.... McElreavey K. (2002)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DMRTC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DMRTC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DMRTC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DMRTC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DMRTC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DMRTC1 gene:
Search GeneIP for patents involving DMRTC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DMRTC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DMRTC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DMRTC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DMRTC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DMRTC1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DMRTC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DMRTC1 | | OriGene Custom Protein Services for DMRTC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMRTC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DMRTC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMRTC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DMRTC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRTC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRTC1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DMRTC1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DMRTC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTC1 |
|  |  |  |  | | | | ThermoFisher Antibodies for DMRTC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRTC1 |
| |  | |
|
|
|
