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Aliases for DMRTB1 Gene

Aliases for DMRTB1 Gene

  • DMRT Like Family B With Proline Rich C-Terminal 1 2 3 5
  • DMRT-Like Family B With Proline-Rich C-Terminal, 1 2

External Ids for DMRTB1 Gene

Previous GeneCards Identifiers for DMRTB1 Gene

  • GC01P053572
  • GC01P052814
  • GC01P053283
  • GC01P053294
  • GC01P053637
  • GC01P053697
  • GC01P053925
  • GC01P052040

Summaries for DMRTB1 Gene

GeneCards Summary for DMRTB1 Gene

DMRTB1 (DMRT Like Family B With Proline Rich C-Terminal 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRTA2.

Additional gene information for DMRTB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTB1 Gene

Genomics for DMRTB1 Gene

Regulatory Elements for DMRTB1 Gene

Enhancers for DMRTB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H053485 0.8 ENCODE 11.8 +26.3 26264 0 CTCF MXI1 RB1 KLF17 ZNF2 RAD21 CC2D1A GLIS2 CTBP1 ZBTB48 DMRTB1 RNU7-95P PIR60882
GH01H053429 0.8 ENCODE dbSUPER 11.2 -28.5 -28479 2 CTCF NRF1 SCRT2 ZSCAN4 POU5F1 DMRTB1 LRP8 MAGOH LOC100507564 LINC01771 RNU7-95P SLC25A3P1 LOC105378733 ENSG00000230138
GH01H053434 0.5 ENCODE dbSUPER 15.6 -24.2 -24241 1 DMRTB1 RNU7-95P SLC25A3P1 LRRC42 LOC105378733 ENSG00000230138
GH01H053447 0.8 ENCODE dbSUPER 9 -10.4 -10422 3 SCRT1 CTCF PKNOX1 SCRT2 POU5F1 ZNF407 PRDM10 RNU7-95P DMRTB1 GC01M053449 SLC25A3P1
GH01H053411 1.4 Ensembl ENCODE dbSUPER 4.6 -46.0 -45966 3 HDGF PKNOX1 ZNF473 BMI1 BATF GLIS2 GATA2 ZSCAN5C ZNF143 FOS LRP8 LOC100507564 MAGOH LINC01771 ENSG00000232762 RNU7-95P DMRTB1 LOC105378733 ENSG00000230138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DMRTB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DMRTB1 Gene

Chromosome:
1
Start:
53,459,399 bp from pter
End:
53,467,488 bp from pter
Size:
8,090 bases
Orientation:
Plus strand

Genomic View for DMRTB1 Gene

Genes around DMRTB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTB1 Gene

Proteins for DMRTB1 Gene

  • Protein details for DMRTB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MA1-DMRTB_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor B1
    Protein Accession:
    Q96MA1
    Secondary Accessions:
    • Q96SD2

    Protein attributes for DMRTB1 Gene

    Size:
    342 amino acids
    Molecular mass:
    36205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMRTB1 Gene

Post-translational modifications for DMRTB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMRTB1 Gene

Domains & Families for DMRTB1 Gene

Gene Families for DMRTB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DMRTB1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96MA1

UniProtKB/Swiss-Prot:

DMRTB_HUMAN :
  • Belongs to the DMRT family.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTB1: view

Function for DMRTB1 Gene

Phenotypes From GWAS Catalog for DMRTB1 Gene

Gene Ontology (GO) - Molecular Function for DMRTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 27107014
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DMRTB1: view
genes like me logo Genes that share phenotypes with DMRTB1: view

Animal Models for DMRTB1 Gene

MGI Knock Outs for DMRTB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DMRTB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMRTB1 Gene

Localization for DMRTB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMRTB1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for DMRTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DMRTB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DMRTB1 Gene

Pathways & Interactions for DMRTB1 Gene

SuperPathways for DMRTB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DMRTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DMRTB1: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTB1 Gene

Drugs & Compounds for DMRTB1 Gene

No Compound Related Data Available

Transcripts for DMRTB1 Gene

mRNA/cDNA for DMRTB1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTB1 Gene

DMRT-like family B with proline-rich C-terminal, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DMRTB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTB1 Gene

No ASD Table

Relevant External Links for DMRTB1 Gene

GeneLoc Exon Structure for
DMRTB1
ECgene alternative splicing isoforms for
DMRTB1

Expression for DMRTB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMRTB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRTB1 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for DMRTB1 Gene

This gene is overexpressed in Testis (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DMRTB1 Gene



Protein tissue co-expression partners for DMRTB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DMRTB1 Gene:

DMRTB1

SOURCE GeneReport for Unigene cluster for DMRTB1 Gene:

Hs.131654

mRNA Expression by UniProt/SwissProt for DMRTB1 Gene:

Q96MA1-DMRTB_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with DMRTB1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMRTB1 Gene

Orthologs for DMRTB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRTB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMRTB1 33 34
  • 94.74 (n)
dog
(Canis familiaris)
Mammalia DMRTB1 33 34
  • 80.64 (n)
cow
(Bos Taurus)
Mammalia DMRTB1 33 34
  • 76.72 (n)
rat
(Rattus norvegicus)
Mammalia Dmrtb1 33
  • 69.09 (n)
mouse
(Mus musculus)
Mammalia Dmrtb1 33 16 34
  • 68.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DMRT1 34
  • 61 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia DMRTB1 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves DMRTB1 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRTB1 34
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dmrt2b 34
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta dsx 34
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-3 34
  • 15 (a)
ManyToMany
Species where no ortholog for DMRTB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DMRTB1 Gene

ENSEMBL:
Gene Tree for DMRTB1 (if available)
TreeFam:
Gene Tree for DMRTB1 (if available)

Paralogs for DMRTB1 Gene

Paralogs for DMRTB1 Gene

genes like me logo Genes that share paralogs with DMRTB1: view

Variants for DMRTB1 Gene

Sequence variations from dbSNP and Humsavar for DMRTB1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000396483 -- 53,460,475(+) CTCCC(G/T)GTTCG intron-variant
rs1000546510 -- 53,464,409(+) TGACC(A/G)TTCAG intron-variant
rs1000693054 -- 53,459,444(+) AGGCT(C/G/T)ACCCT utr-variant-5-prime
rs1000729915 -- 53,459,182(+) TGACA(A/T)ACATG upstream-variant-2KB
rs1000939860 -- 53,464,131(+) CAGAC(A/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTB1 Gene

Variant ID Type Subtype PubMed ID
esv2758936 CNV loss 17122850
nsv428443 CNV gain 18775914
nsv509269 CNV insertion 20534489
nsv829882 CNV loss 17160897
nsv877 CNV insertion 18451855

Variation tolerance for DMRTB1 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRTB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMRTB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTB1 Gene

Disorders for DMRTB1 Gene

Relevant External Links for DMRTB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRTB1

No disorders were found for DMRTB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTB1 Gene

Publications for DMRTB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C … McElreavey K (Genomics 2002) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 60

Products for DMRTB1 Gene

Sources for DMRTB1 Gene

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