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Aliases for DMRTB1 Gene

Aliases for DMRTB1 Gene

  • DMRT Like Family B With Proline Rich C-Terminal 1 2 3 5
  • DMRT-Like Family B With Proline-Rich C-Terminal, 1 2

External Ids for DMRTB1 Gene

Previous GeneCards Identifiers for DMRTB1 Gene

  • GC01P053572
  • GC01P052814
  • GC01P053283
  • GC01P053294
  • GC01P053637
  • GC01P053697
  • GC01P053925
  • GC01P052040

Summaries for DMRTB1 Gene

GeneCards Summary for DMRTB1 Gene

DMRTB1 (DMRT Like Family B With Proline Rich C-Terminal 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTB1 Gene

Genomics for DMRTB1 Gene

Regulatory Elements for DMRTB1 Gene

Enhancers for DMRTB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DMRTB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DMRTB1 Gene

Chromosome:
1
Start:
53,459,399 bp from pter
End:
53,467,488 bp from pter
Size:
8,090 bases
Orientation:
Plus strand

Genomic View for DMRTB1 Gene

Genes around DMRTB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTB1 Gene

Proteins for DMRTB1 Gene

  • Protein details for DMRTB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MA1-DMRTB_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor B1
    Protein Accession:
    Q96MA1
    Secondary Accessions:
    • Q96SD2

    Protein attributes for DMRTB1 Gene

    Size:
    342 amino acids
    Molecular mass:
    36205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMRTB1 Gene

Proteomics data for DMRTB1 Gene at MOPED

Post-translational modifications for DMRTB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMRTB1 Gene

Domains & Families for DMRTB1 Gene

Protein Domains for DMRTB1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96MA1

UniProtKB/Swiss-Prot:

DMRTB_HUMAN :
  • Contains 1 DM DNA-binding domain.
  • Belongs to the DMRT family.
Domain:
  • Contains 1 DM DNA-binding domain.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTB1: view

No data available for Gene Families for DMRTB1 Gene

Function for DMRTB1 Gene

Gene Ontology (GO) - Molecular Function for DMRTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0042803 protein homodimerization activity IBA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DMRTB1: view
genes like me logo Genes that share phenotypes with DMRTB1: view

Animal Models for DMRTB1 Gene

MGI Knock Outs for DMRTB1:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMRTB1 Gene

Localization for DMRTB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRTB1 Gene COMPARTMENTS Subcellular localization image for DMRTB1 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for DMRTB1 Gene

Pathways & Interactions for DMRTB1 Gene

SuperPathways for DMRTB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DMRTB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DMRTB1 Gene

Drugs & Compounds for DMRTB1 Gene

No Compound Related Data Available

Transcripts for DMRTB1 Gene

mRNA/cDNA for DMRTB1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTB1 Gene

DMRT-like family B with proline-rich C-terminal, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTB1 Gene

No ASD Table

Relevant External Links for DMRTB1 Gene

GeneLoc Exon Structure for
DMRTB1
ECgene alternative splicing isoforms for
DMRTB1

Expression for DMRTB1 Gene

mRNA expression in normal human tissues for DMRTB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRTB1 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for DMRTB1 Gene

This gene is overexpressed in Testis (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DMRTB1 Gene



SOURCE GeneReport for Unigene cluster for DMRTB1 Gene Hs.131654

mRNA Expression by UniProt/SwissProt for DMRTB1 Gene

Q96MA1-DMRTB_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with DMRTB1: view

Protein tissue co-expression partners for DMRTB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DMRTB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRTB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DMRTB1 35
  • 76.72 (n)
  • 67.69 (a)
DMRTB1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMRTB1 35
  • 80.64 (n)
  • 73.31 (a)
DMRTB1 36
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmrtb1 35
  • 68.83 (n)
  • 55.56 (a)
Dmrtb1 16
Dmrtb1 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DMRTB1 35
  • 94.74 (n)
  • 92.69 (a)
DMRTB1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmrtb1 35
  • 69.09 (n)
  • 56.36 (a)
oppossum
(Monodelphis domestica)
Mammalia DMRTB1 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMRT1 36
  • 61 (a)
ManyToMany
chicken
(Gallus gallus)
Aves DMRTB1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRTB1 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dmrt2b 36
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta dsx 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-3 36
  • 15 (a)
ManyToMany
Species with no ortholog for DMRTB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DMRTB1 Gene

ENSEMBL:
Gene Tree for DMRTB1 (if available)
TreeFam:
Gene Tree for DMRTB1 (if available)

Paralogs for DMRTB1 Gene

Paralogs for DMRTB1 Gene

genes like me logo Genes that share paralogs with DMRTB1: view

Variants for DMRTB1 Gene

Sequence variations from dbSNP and Humsavar for DMRTB1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs732385 -- 53,462,507(-) TCTCA(C/T)AACAT intron-variant
rs1108988 -- 53,463,923(-) ATCAG(A/G)GGATC intron-variant
rs1108989 -- 53,463,790(-) AACAC(A/T)TCCTG intron-variant
rs943514 -- 53,464,878(+) TCAGC(A/G)AGAGC intron-variant
rs943521 -- 53,461,976(+) AAGGG(A/C)ATATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTB1 Gene

Variant ID Type Subtype PubMed ID
nsv509269 CNV Insertion 20534489
nsv871730 CNV Loss 21882294
nsv877 CNV Insertion 18451855
nsv829882 CNV Loss 17160897
dgv227n71 CNV Loss 21882294
dgv52e1 CNV Complex 17122850
nsv428443 CNV Gain 18775914

Variation tolerance for DMRTB1 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRTB1 Gene

HapMap Linkage Disequilibrium report
DMRTB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTB1 Gene

Disorders for DMRTB1 Gene

Relevant External Links for DMRTB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRTB1

No disorders were found for DMRTB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTB1 Gene

Publications for DMRTB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3

Products for DMRTB1 Gene

Sources for DMRTB1 Gene

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