DMRTB1 Gene
protein-coding GIFtS : 47
GCID: GC01 P053925
DMRT-like family B with proline-rich C-terminal, 1
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Aliasesfor DMRTB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DMRT-Like Family B With Proline-Rich C-Terminal, 1 1 2 Doublesex- And Mab-3-Related Transcription Factor B12
Export aliases for DMRTB1 gene to outside databases Previous GC identifers: GC01P053572 GC01P052814 GC01P053283 GC01P053294 GC01P053637 GC01P053697 GC01P052040
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Summariesfor DMRTB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor DMRTB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DMRTB1 gene promoter: Nkx3-1 Nkx3-1 v2 Nkx3-1 v4 p53 HNF-1 Chx10 Nkx3-1 v3 Nkx3-1 v1 Pax-4a HNF-1A Other transcription factors Search SABiosciences Chromatin IP Primers for DMRTB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DMRTB1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32 DMRTB1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P053925: view genomic region
(about GC identifiers )
Start:
53,925,072 bp from pter
End:
53,933,161 bp from pter
Size:
8,090 bases
Orientation:
plus strand
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Proteinsfor DMRTB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DMRTB_HUMAN, Q96MA1 (See
protein sequence )Recommended Name: Doublesex- and mab-3-related transcription factor B1 Size : 342 amino acids; 36205 Da
Subcellular location : Nucleus (Potential)
Secondary accessions : Q96SD2Explore the universe of human proteins at neXtProt for DMRTB1: NX_Q96MA1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96MA1 DMRTB1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_149056.1 ENSEMBL proteins: ENSP00000360500 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
DMRTB1 for ontologies About GeneDecksing DMRTB1 Antibody Products: Assay Products for DMRTB1:
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Protein
Domains / Familiesfor DMRTB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DMRTB1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96MA1 ProtoNet protein and cluster: Q96MA1
1 Blocks protein family : IPB001275 DM DNA-binding UniProtKB/Swiss-Prot: DMRTB_HUMAN, Q96MA1 Similarity : Belongs to the DMRT familySimilarity : Contains 1 DM DNA-binding domain
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Functionfor DMRTB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTB1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTB1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DMRTB1 (NM_033067 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTB1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTB1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
DMRTB1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for DMRTB1 :
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Pathways & Interactionsfor DMRTB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMRTB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)5/28 Interacting proteins for DMRTB1 (Q96MA1 2 , 3 ENSP00000360500 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 28 )Interactant Interaction Details GeneCard External ID(s) RBFOX1 Q9NWB1 2 , 3 , ENSP00000309117 4 MINT-2875657 I2D:
score=3 STRING: ENSP00000309117 VASP P50552 2 , 3 , ENSP00000245932 4 MINT-66826 I2D:
score=5 STRING: ENSP00000245932 NIF3L1 Q9GZT8 2 , 3 , ENSP00000386394 4 MINT-67776 I2D:
score=5 STRING: ENSP00000386394 EYA2 O00167 2 , 3 , ENSP00000333640 4 MINT-66157 I2D:
score=3 STRING: ENSP00000333640 RBFOX2 O43251 2 , 3 , ENSP00000413035 4 MINT-67864 I2D:
score=4 STRING: ENSP00000413035
About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007548 sex differentiation
IEA --
DMRTB1 for ontologies About GeneDecksing
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Drugs & Compoundsfor DMRTB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DMRTB1 Search CenterWatch for drugs/clinical trials and news about DMRTB1 / DMRTB
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Transcriptsfor DMRTB1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DMRTB1 gene: NM_033067.1 Unigene Cluster for DMRTB1:
DMRT-like family B with proline-rich C-terminal, 1 Hs.131654 [show with all ESTs ] Unigene Representative Sequence: AK057273 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000371445 (uc001cvq.1 ) ENST00000463126 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTB1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTB1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DMRTB1 (NM_033067 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTB1
Additional cDNA sequence: AJ291671.1 AK057273.1 AK302085.1 BC029566.1
3 DOTS entries : DT.205919 DT.121378749
DT.95158383 24 AceView cDNA sequences :
BX115913 BX339185 AJ291671 BC029566 AI198850 CR595262 BG717887 BI831691 AI025780 AI027193 AA921760 NM_033067 AK057273 AI269604 BI462321 BF979817 BG718134 BG772909 BI826473 BG771525 BI462304 AW172417 BF979281 BX327965 GeneLoc Exon Structure
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Expression for DMRTB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DMRTB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AACAGTTTCT
About this image DMRTB1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DMRTB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DMRTB1 SOURCE GeneReport for Unigene cluster: Hs.131654 UniProtKB/Swiss-Prot: DMRTB_HUMAN, Q96MA1 Tissue specificity : Testis SABiosciences Custom PCR Arrays for DMRTB1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DMRTB1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DMRTB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DMRTB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DMRTB1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTB1
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Orthologsfor DMRTB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for DMRTB1 gene from 4/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for DMRTB1 (if available)TreeFam Gene Tree for DMRTB1 (if available)
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Paralogsfor DMRTB1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DMRTB1 gene DMRT2 2 DMRT3 2 DMRTA2 2 DMRT1 2 DMRTA1 2
DMRTB1 for paralogs About GeneDecksing
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Genomic Variantsfor DMRTB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DMRTB1 (53925072 - 53933161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for DMRTB1 1 CNV : 3291
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DMRTB1
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Disorders
/ Diseasesfor DMRTB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DMRTB1 for disorders About GeneDecksing
OMIM gene information: 614805
OMIM disorders : --1 disease for DMRTB1 : About MalaCards ataxia Export disorders for DMRTB1 gene to outside databases
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Publicationsfor DMRTB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DMRTB1 gene integrated from 9 sources : (articles sorted by number of sources associating them with DMRTB1) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PubMed id 11863363) 1 , 2 Ottolenghi C.... McElreavey K. (2002) Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536) 1 Barber M.J....Krauss R.M. (2010) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569) 1 Lim J.... Zoghbi H.Y. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DMRTB1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DMRTB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DMRTB1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DMRTB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DMRTB1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DMRTB1 gene: Search GeneIP for patents involving DMRTB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DMRTB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DMRTB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DMRTB1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DMRTB1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DMRTB1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTB1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DMRTB1 OriGene Custom Protein Services for DMRTB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMRTB1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DMRTB1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DMRTB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DMRTB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DMRTB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DMRTB1
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DMRTB1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTB1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTB1
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