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Aliases for DMRTA2 Gene

Aliases for DMRTA2 Gene

  • DMRT Like Family A2 2 3 5
  • Doublesex- And Mab-3-Related Transcription Factor 5 4
  • DMRT-Like Family A2 2
  • DMRT5 4

External Ids for DMRTA2 Gene

Previous GeneCards Identifiers for DMRTA2 Gene

  • GC01M050508
  • GC01M049773
  • GC01M050242
  • GC01M050254
  • GC01M050243
  • GC01M050596
  • GC01M050656
  • GC01M050883
  • GC01M049001

Summaries for DMRTA2 Gene

GeneCards Summary for DMRTA2 Gene

DMRTA2 (DMRT Like Family A2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRTA1.

UniProtKB/Swiss-Prot for DMRTA2 Gene

  • May be involved in sexual development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTA2 Gene

Genomics for DMRTA2 Gene

Regulatory Elements for DMRTA2 Gene

Enhancers for DMRTA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F050393 0.6 ENCODE 15.5 +29.5 29461 0.8 ZNF280D KDM1A DMRTA2 HMGB1P45 GC01M050274
GH01F050667 0.8 Ensembl ENCODE 10.5 -244.6 -244601 0.6 ZNF316 CBX5 ZNF547 MAFK DMRTA2 GC01M050672 GC01M050645
GH01F050975 1 Ensembl ENCODE 5.2 -554.6 -554612 5.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000266993 RPS2P8 DMRTA2 CDKN2C GC01M050992 GC01M050995
GH01F050966 1.1 ENCODE 5 -546.4 -546432 6.3 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000266993 DMRTA2 CDKN2C GC01M050992 GC01M050995
GH01F050699 2.3 VISTA ENCODE 4.7 -276.8 -276819 1.6 CEBPB FEZF1 ZIC2 ZNF843 OSR2 JUND BCL11A POLR2A SMARCA4 POU5F1 DMRTA2 CDKN2C GC01M050693 GC01M050672
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DMRTA2 on UCSC Golden Path with GeneCards custom track

Promoters for DMRTA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744767 -300 401 SUZ12 ZNF316 GLIS2 ZBTB48 PRDM10 ZBTB20 EZH2 MAZ RNF2 SP2

Genomic Location for DMRTA2 Gene

Chromosome:
1
Start:
50,417,550 bp from pter
End:
50,423,500 bp from pter
Size:
5,951 bases
Orientation:
Minus strand

Genomic View for DMRTA2 Gene

Genes around DMRTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTA2 Gene

Proteins for DMRTA2 Gene

  • Protein details for DMRTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SC8-DMTA2_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor A2
    Protein Accession:
    Q96SC8
    Secondary Accessions:
    • Q5TFQ3

    Protein attributes for DMRTA2 Gene

    Size:
    542 amino acids
    Molecular mass:
    53356 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMRTA2 Gene

Post-translational modifications for DMRTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMRTA2 Gene

Domains & Families for DMRTA2 Gene

Protein Domains for DMRTA2 Gene

Suggested Antigen Peptide Sequences for DMRTA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SC8

UniProtKB/Swiss-Prot:

DMTA2_HUMAN :
  • Contains 1 DM DNA-binding domain.
  • Belongs to the DMRT family.
Domain:
  • Contains 1 DM DNA-binding domain.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTA2: view

No data available for Gene Families for DMRTA2 Gene

Function for DMRTA2 Gene

Molecular function for DMRTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sexual development.

Gene Ontology (GO) - Molecular Function for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0042803 protein homodimerization activity IEA,IBA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DMRTA2: view
genes like me logo Genes that share phenotypes with DMRTA2: view

Animal Models for DMRTA2 Gene

MGI Knock Outs for DMRTA2:

Animal Model Products

miRNA for DMRTA2 Gene

miRTarBase miRNAs that target DMRTA2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMRTA2 Gene

Localization for DMRTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRTA2 Gene COMPARTMENTS Subcellular localization image for DMRTA2 gene
Compartment Confidence
nucleus 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DMRTA2: view

Pathways & Interactions for DMRTA2 Gene

SuperPathways for DMRTA2 Gene

No Data Available

Interacting Proteins for DMRTA2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383909%0d%0a9606.ENSP00000314343%0d%0a9606.ENSP00000438465%0d%0a
Selected Interacting proteins: ENSP00000383909 Q96SC8-DMTA2_HUMAN for DMRTA2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development IBA --
GO:0007548 sex differentiation IBA --
GO:0021796 cerebral cortex regionalization IEA --
genes like me logo Genes that share ontologies with DMRTA2: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTA2 Gene

Transcripts for DMRTA2 Gene

mRNA/cDNA for DMRTA2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTA2 Gene

DMRT-like family A2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTA2 Gene

No ASD Table

Relevant External Links for DMRTA2 Gene

GeneLoc Exon Structure for
DMRTA2
ECgene alternative splicing isoforms for
DMRTA2

Expression for DMRTA2 Gene

mRNA expression in normal human tissues for DMRTA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRTA2 Gene

This gene is overexpressed in Pituitary (x13.9), Testis (x11.3), Esophagus - Mucosa (x8.2), and Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for DMRTA2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMRTA2 Gene



Protein tissue co-expression partners for DMRTA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DMRTA2 Gene:

DMRTA2

SOURCE GeneReport for Unigene cluster for DMRTA2 Gene:

Hs.334481

mRNA Expression by UniProt/SwissProt for DMRTA2 Gene:

Q96SC8-DMTA2_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with DMRTA2: view

Primer Products

Orthologs for DMRTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMRTA2 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia DMRTA2 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMRTA2 34 35
  • 89.97 (n)
mouse
(Mus musculus)
Mammalia Dmrta2 34 16 35
  • 86.88 (n)
oppossum
(Monodelphis domestica)
Mammalia DMRTA2 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRTA2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmrta2 34
  • 67.39 (n)
Str.14215 34
zebrafish
(Danio rerio)
Actinopterygii dmrta2 34 35
  • 67.57 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4887 34
fruit fly
(Drosophila melanogaster)
Insecta dmrt99B 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dmd-5 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for DMRTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMRTA2 Gene

ENSEMBL:
Gene Tree for DMRTA2 (if available)
TreeFam:
Gene Tree for DMRTA2 (if available)

Paralogs for DMRTA2 Gene

Paralogs for DMRTA2 Gene

(2) SIMAP similar genes for DMRTA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DMRTA2: view

Variants for DMRTA2 Gene

Sequence variations from dbSNP and Humsavar for DMRTA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10159175 -- 50,418,454(+) CACCC(A/C)CTCCG utr-variant-3-prime
rs111813947 -- 50,420,788(+) ATGCT(C/T)CAGAA intron-variant
rs112710427 -- 50,420,854(+) GTGAA(A/C)CCTAG intron-variant
rs113089675 -- 50,420,540(+) CTCAG(-/AACCTAGGGCGTCTCAA)AACCT intron-variant
rs11340552 -- 50,421,036(+) CAGGT(-/C)CCCCC reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTA2 Gene

Variant ID Type Subtype PubMed ID
nsv950717 CNV deletion 24416366

Variation tolerance for DMRTA2 Gene

Gene Damage Index Score: 1.77; 33.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRTA2 Gene

Human Gene Mutation Database (HGMD)
DMRTA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMRTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTA2 Gene

Disorders for DMRTA2 Gene

Relevant External Links for DMRTA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRTA2

No disorders were found for DMRTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTA2 Gene

Publications for DMRTA2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 2 3 4 64
  2. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. (PMID: 25082981) Poulain M. … Livera G. (Mol. Hum. Reprod. 2014) 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for DMRTA2 Gene

Sources for DMRTA2 Gene

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