Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DMRTA2 Gene

Aliases for DMRTA2 Gene

  • DMRT Like Family A2 2 3 5
  • Doublesex- And Mab-3-Related Transcription Factor 5 4
  • DMRT-Like Family A2 2
  • DMRT5 4

External Ids for DMRTA2 Gene

Previous GeneCards Identifiers for DMRTA2 Gene

  • GC01M050508
  • GC01M049773
  • GC01M050242
  • GC01M050254
  • GC01M050243
  • GC01M050596
  • GC01M050656
  • GC01M050883
  • GC01M049001

Summaries for DMRTA2 Gene

GeneCards Summary for DMRTA2 Gene

DMRTA2 (DMRT Like Family A2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRTA1.

UniProtKB/Swiss-Prot for DMRTA2 Gene

  • May be involved in sexual development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTA2 Gene

Genomics for DMRTA2 Gene

Regulatory Elements for DMRTA2 Gene

Enhancers for DMRTA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G050699 2.5 VISTA ENCODE dbSUPER 4.7 -276.8 -276819 1.6 FEZF1 CHD7 ZIC2 POLR2A ZSCAN5C EZH2 TCF7L2 CEBPB ZNF843 OSR2 DMRTA2 CDKN2C GC01M050693 GC01M050672
GH01G050975 1.6 Ensembl ENCODE dbSUPER 5.2 -554.5 -554522 5.2 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 DMRTA2 CDKN2C GC01M050995 GC01M050992
GH01G050966 1.4 ENCODE dbSUPER 5 -546.4 -546432 6.3 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF263 SP3 MEF2D SSRP1 DMRTA2 CDKN2C GC01M050995 GC01M050992
GH01G050393 0.4 ENCODE 15.5 +29.5 29461 0.8 ZNF280D KDM1A DMRTA2 HMGB1P45 GC01M050274
GH01G050716 0.8 dbSUPER 4.6 -294.1 -294069 1.3 ZBTB21 ZFP64 ZNF140 ZNF266 ZNF101 ZNF697 ZNF664 ZNF121 ZNF433 ZNF680 LINC01562 DMRTA2 GC01M050693 GC01P050736 GC01P050738 GC01P050737 GC01P050735 GC01P050734 GC01P050733 GC01P050732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DMRTA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DMRTA2 Gene

Chromosome:
1
Start:
50,417,550 bp from pter
End:
50,423,500 bp from pter
Size:
5,951 bases
Orientation:
Minus strand

Genomic View for DMRTA2 Gene

Genes around DMRTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTA2 Gene

Proteins for DMRTA2 Gene

  • Protein details for DMRTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SC8-DMTA2_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor A2
    Protein Accession:
    Q96SC8
    Secondary Accessions:
    • Q5TFQ3

    Protein attributes for DMRTA2 Gene

    Size:
    542 amino acids
    Molecular mass:
    53356 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMRTA2 Gene

Post-translational modifications for DMRTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMRTA2 Gene

Domains & Families for DMRTA2 Gene

Protein Domains for DMRTA2 Gene

Suggested Antigen Peptide Sequences for DMRTA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SC8

UniProtKB/Swiss-Prot:

DMTA2_HUMAN :
  • Belongs to the DMRT family.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTA2: view

No data available for Gene Families for DMRTA2 Gene

Function for DMRTA2 Gene

Molecular function for DMRTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sexual development.

Gene Ontology (GO) - Molecular Function for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DMRTA2: view
genes like me logo Genes that share phenotypes with DMRTA2: view

Animal Models for DMRTA2 Gene

MGI Knock Outs for DMRTA2:

Animal Model Products

CRISPR Products

miRNA for DMRTA2 Gene

miRTarBase miRNAs that target DMRTA2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMRTA2 Gene

Localization for DMRTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMRTA2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DMRTA2: view

Pathways & Interactions for DMRTA2 Gene

SuperPathways for DMRTA2 Gene

No Data Available

Interacting Proteins for DMRTA2 Gene

Gene Ontology (GO) - Biological Process for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development IBA --
GO:0021796 cerebral cortex regionalization IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with DMRTA2: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTA2 Gene

Transcripts for DMRTA2 Gene

mRNA/cDNA for DMRTA2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTA2 Gene

DMRT-like family A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTA2 Gene

No ASD Table

Relevant External Links for DMRTA2 Gene

GeneLoc Exon Structure for
DMRTA2
ECgene alternative splicing isoforms for
DMRTA2

Expression for DMRTA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMRTA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRTA2 Gene

This gene is overexpressed in Pituitary (x13.9), Testis (x11.3), Esophagus - Mucosa (x8.2), and Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for DMRTA2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMRTA2 Gene



Protein tissue co-expression partners for DMRTA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DMRTA2 Gene:

DMRTA2

SOURCE GeneReport for Unigene cluster for DMRTA2 Gene:

Hs.334481

mRNA Expression by UniProt/SwissProt for DMRTA2 Gene:

Q96SC8-DMTA2_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with DMRTA2: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMRTA2 Gene

Orthologs for DMRTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMRTA2 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia DMRTA2 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMRTA2 34 35
  • 89.97 (n)
mouse
(Mus musculus)
Mammalia Dmrta2 34 16 35
  • 86.88 (n)
oppossum
(Monodelphis domestica)
Mammalia DMRTA2 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRTA2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmrta2 34
  • 67.39 (n)
Str.14215 34
zebrafish
(Danio rerio)
Actinopterygii dmrta2 34 35
  • 67.57 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4887 34
fruit fly
(Drosophila melanogaster)
Insecta dmrt99B 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dmd-5 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for DMRTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMRTA2 Gene

ENSEMBL:
Gene Tree for DMRTA2 (if available)
TreeFam:
Gene Tree for DMRTA2 (if available)

Paralogs for DMRTA2 Gene

Paralogs for DMRTA2 Gene

(2) SIMAP similar genes for DMRTA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DMRTA2: view

Variants for DMRTA2 Gene

Sequence variations from dbSNP and Humsavar for DMRTA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000251183 -- 50,421,771(+) TACAC(G/T)CTAGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000429618 -- 50,418,015(+) TATAT(-/ATAG)ATTTA utr-variant-3-prime
rs1000641211 -- 50,421,379(+) GCGGC(C/T)CCCGC reference, missense
rs1000706353 -- 50,422,245(+) GACCC(A/G)TAAAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000901871 -- 50,422,631(+) GAAGA(-/C)CCACC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DMRTA2 Gene

Variant ID Type Subtype PubMed ID
nsv950717 CNV deletion 24416366

Variation tolerance for DMRTA2 Gene

Gene Damage Index Score: 1.77; 33.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRTA2 Gene

Human Gene Mutation Database (HGMD)
DMRTA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMRTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTA2 Gene

Disorders for DMRTA2 Gene

Relevant External Links for DMRTA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRTA2

No disorders were found for DMRTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTA2 Gene

Publications for DMRTA2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 2 3 4 64
  2. DMRTA2 (DMRT5) is mutated in a novel cortical brain malformation. (PMID: 26757254) Urquhart J.E. … Newman W.G. (Clin. Genet. 2016) 3 64
  3. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. (PMID: 25082981) Poulain M. … Livera G. (Mol. Hum. Reprod. 2014) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for DMRTA2 Gene

Sources for DMRTA2 Gene

Content
Loading form....