Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DMRTA2 Gene

Aliases for DMRTA2 Gene

  • DMRT-Like Family A2 2 3
  • Doublesex- And Mab-3-Related Transcription Factor 5 4
  • DMRT5 4

External Ids for DMRTA2 Gene

Previous GeneCards Identifiers for DMRTA2 Gene

  • GC01M050508
  • GC01M049773
  • GC01M050242
  • GC01M050254
  • GC01M050243
  • GC01M050596
  • GC01M050656
  • GC01M050883
  • GC01M049001

Summaries for DMRTA2 Gene

GeneCards Summary for DMRTA2 Gene

DMRTA2 (DMRT-Like Family A2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DMRT2.

UniProtKB/Swiss-Prot for DMRTA2 Gene

  • May be involved in sexual development

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTA2 Gene

Genomics for DMRTA2 Gene

Regulatory Elements for DMRTA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DMRTA2 Gene

Start:
50,417,550 bp from pter
End:
50,423,500 bp from pter
Size:
5,951 bases
Orientation:
Minus strand

Genomic View for DMRTA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMRTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTA2 Gene

Proteins for DMRTA2 Gene

  • Protein details for DMRTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SC8-DMTA2_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor A2
    Protein Accession:
    Q96SC8
    Secondary Accessions:
    • Q5TFQ3

    Protein attributes for DMRTA2 Gene

    Size:
    542 amino acids
    Molecular mass:
    53356 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMRTA2 Gene

Proteomics data for DMRTA2 Gene at MOPED

Post-translational modifications for DMRTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DMRTA2 Gene

Domains for DMRTA2 Gene

Protein Domains for DMRTA2 Gene

Suggested Antigen Peptide Sequences for DMRTA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SC8

UniProtKB/Swiss-Prot:

DMTA2_HUMAN :
  • Q96SC8
Domain:
  • Contains 1 DM DNA-binding domain.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTA2: view

No data available for Gene Families for DMRTA2 Gene

Function for DMRTA2 Gene

Molecular function for DMRTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sexual development

Gene Ontology (GO) - Molecular Function for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IBA --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with DMRTA2: view

Phenotypes for DMRTA2 Gene

genes like me logo Genes that share phenotypes with DMRTA2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMRTA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DMRTA2 Gene

Localization for DMRTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRTA2 Gene COMPARTMENTS Subcellular localization image for DMRTA2 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DMRTA2: view

Pathways for DMRTA2 Gene

SuperPathways for DMRTA2 Gene

No Data Available

Interacting Proteins for DMRTA2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383909%0d%0a9606.ENSP00000314343%0d%0a9606.ENSP00000438465%0d%0a
Selected Interacting proteins: ENSP00000383909 for DMRTA2 Gene via STRING

Gene Ontology (GO) - Biological Process for DMRTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development IBA --
GO:0007548 sex differentiation IBA --
GO:0021796 cerebral cortex regionalization IEA --
genes like me logo Genes that share ontologies with DMRTA2: view

No data available for Pathways by source for DMRTA2 Gene

Transcripts for DMRTA2 Gene

mRNA/cDNA for DMRTA2 Gene

(11) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTA2 Gene

DMRT-like family A2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMRTA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTA2 Gene

No ASD Table

Relevant External Links for DMRTA2 Gene

GeneLoc Exon Structure for
DMRTA2
ECgene alternative splicing isoforms for
DMRTA2

Expression for DMRTA2 Gene

mRNA expression in normal human tissues for DMRTA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRTA2 Gene

This gene is overexpressed in Pituitary (13.9), Testis (11.3), Esophagus - Mucosa (8.2), and Brain - Spinal cord (cervical c-1) (4.5).

Protein differential expression in normal tissues for DMRTA2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMRTA2 Gene

SOURCE GeneReport for Unigene cluster for DMRTA2 Gene Hs.334481

mRNA Expression by UniProt/SwissProt for DMRTA2 Gene

Q96SC8-DMTA2_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with DMRTA2: view

Expression partners for DMRTA2 Gene

In Situ Assay Products

Orthologs for DMRTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRTA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DMRTA2 35
  • 89.97 (n)
  • 96.64 (a)
DMRTA2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmrta2 35
  • 86.88 (n)
  • 93.41 (a)
Dmrta2 16
Dmrta2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DMRTA2 35
  • 99.57 (n)
  • 99.81 (a)
DMRTA2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMRTA2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMRTA2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRTA2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmrta2 35
  • 67.39 (n)
  • 74.58 (a)
Str.14215 35
zebrafish
(Danio rerio)
Actinopterygii dmrta2 35
  • 67.57 (n)
  • 69.36 (a)
dmrta2 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4887 35
fruit fly
(Drosophila melanogaster)
Insecta dmrt99B 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dmd-5 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for DMRTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMRTA2 Gene

ENSEMBL:
Gene Tree for DMRTA2 (if available)
TreeFam:
Gene Tree for DMRTA2 (if available)

Paralogs for DMRTA2 Gene

Paralogs for DMRTA2 Gene

Selected SIMAP similar genes for DMRTA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DMRTA2: view

Variants for DMRTA2 Gene

Sequence variations from dbSNP and Humsavar for DMRTA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1278527 -- 50,425,295(-) CGAGT(A/G)ACCAG upstream-variant-2KB
rs1278528 -- 50,424,977(-) CGACG(A/C)CCCGG upstream-variant-2KB
rs1278529 -- 50,424,962(-) AGTCT(A/G)CGCGC upstream-variant-2KB
rs1278530 -- 50,423,583(-) CACTG(C/T)AGAAT upstream-variant-2KB
rs1278531 -- 50,420,924(-) GGGGC(A/G)CGGGG intron-variant

Relevant External Links for DMRTA2 Gene

HapMap Linkage Disequilibrium report
DMRTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DMRTA2 Gene

Disorders for DMRTA2 Gene

No disorders were found for DMRTA2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DMRTA2 Gene

Publications for DMRTA2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for DMRTA2 Gene

Sources for DMRTA2 Gene

Back to Top

Content