DMRTA2 Gene
protein-coding GIFtS : 44
GCID: GC01 M050883
DMRT-like family A2
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Aliasesfor DMRTA2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DMRT-Like Family A2 1 2 Doublesex- And Mab-3-Related Transcription Factor 52 3 Doublesex- And Mab-3-Related Transcription Factor A22 DMRT53
Export aliases for DMRTA2 gene to outside databases Previous GC identifers: GC01M050508 GC01M049773 GC01M050242 GC01M050254 GC01M050243 GC01M050596 GC01M050656 GC01M049001
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Summariesfor DMRTA2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DMTA2_HUMAN, Q96SC8 Function : May be involved in sexual development
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Genomic Viewsfor DMRTA2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DMRTA2 gene promoter: Max1 USF1 Pax-5 SREBP-1c N-Myc SREBP-1a Ik-2 CP2 USF-1 c-Myb Other transcription factors Search SABiosciences Chromatin IP Primers for DMRTA2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DMRTA2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p33 DMRTA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M050883: view genomic region
(about GC identifiers )
Start:
50,883,222 bp from pter
End:
50,889,172 bp from pter
Size:
5,951 bases
Orientation:
minus strand
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Proteinsfor DMRTA2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DMTA2_HUMAN, Q96SC8 (See
protein sequence )Recommended Name: Doublesex- and mab-3-related transcription factor A2 Size : 542 amino acids; 53356 Da
Subcellular location : Nucleus (Potential)
Secondary accessions : Q5TFQ3Explore the universe of human proteins at neXtProt for DMRTA2: NX_Q96SC8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96SC8 DMRTA2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_115486.1 ENSEMBL proteins: ENSP00000383909 ENSP00000399370 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
DMRTA2 for ontologies About GeneDecksing DMRTA2 Antibody Products: Assay Products for DMRTA2:
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Protein
Domains / Familiesfor DMRTA2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DMRTA2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96SC8 ProtoNet protein and cluster: Q96SC8
1 Blocks protein family : IPB001275 DM DNA-binding UniProtKB/Swiss-Prot: DMTA2_HUMAN, Q96SC8 Similarity : Belongs to the DMRT familySimilarity : Contains 1 DM DNA-binding domain
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Functionfor DMRTA2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DMTA2_HUMAN, Q96SC8 Function : May be involved in sexual development
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTA2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTA2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DMRTA2 (NM_032110 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTA2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTA2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTA2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0043565 sequence-specific DNA binding
IEA -- GO:0046872 metal ion binding
IEA --
DMRTA2 for ontologies About GeneDecksing
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Pathways & Interactionsfor DMRTA2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMRTA2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)5/14 Interacting proteins for DMRTA2 (ENSP00000383909 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 14 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007548 sex differentiation
IEA --
DMRTA2 for ontologies About GeneDecksing
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Drugs & Compoundsfor DMRTA2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DMRTA2 Search CenterWatch for drugs/clinical trials and news about DMRTA2 / DMTA2
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Transcriptsfor DMRTA2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
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Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DMRTA2 gene: NM_032110.2 Unigene Cluster for DMRTA2:
DMRT-like family A2 Hs.334481 [show with all ESTs ] Unigene Representative Sequence: NM_032110 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000404795 (uc010onb.2 ) ENST00000418121 (uc010ona.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTA2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTA2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DMRTA2 (NM_032110 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DMRTA2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTA2
Additional cDNA sequence: AJ301580.1 BC136282.1 BC143800.1
2 DOTS entries : DT.95193645 DT.97804738
11 AceView cDNA sequences :
BQ941189 BG056274 BE540441 AI492131 AJ301580 BU727085 BM560708 BM931712 BE294804 BM726531 BM688501 GeneLoc Exon Structure
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Expression for DMRTA2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DMRTA2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGTTTCCTTG
About this image DMRTA2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See DMRTA2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DMRTA2 SOURCE GeneReport for Unigene cluster: Hs.334481 UniProtKB/Swiss-Prot: DMTA2_HUMAN, Q96SC8 Tissue specificity : Expressed in testis SABiosciences Custom PCR Arrays for DMRTA2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DMRTA2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DMRTA2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DMRTA2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DMRTA2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTA2
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Orthologsfor DMRTA2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for DMRTA2 gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
DMRTA26
--
60(a)
1 ↔ 1
4(113497050-113503259)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.142152
Transcribed sequence with weak similarity to protein more
73.87(n)
 
137725954
zebrafish (Danio rerio)
Actinopterygii
dmrta21
doublesex and mab-3 related transcription factor like more
66.36(n) 68.49(a)
 
474350 NM_001007064.2 NP_001007065.2
fruit fly (Drosophila melanogaster)
Insecta
dmrt99B6
doublesex-Mab related 99B
25(a)
1 → many
3R(25518313-25522747)
worm (Caenorhabditis elegans)
Secernentea
dmd-56
DM (Doublesex/MAB-3) Domain family member (dmd-5)
28(a)
1 → many
II(5772045-5774200)
ENSEMBL Gene Tree for DMRTA2 (if available)TreeFam Gene Tree for DMRTA2 (if available)
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Paralogsfor DMRTA2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DMRTA2 gene DMRT2 2 DMRT3 2 DMRT1 2 DMRTA1 2 DMRTB1 2 2 SIMAP similar genes for DMRTA2 using alignment to 3 protein entries: DMTA2_HUMAN (see all proteins ):DMRT2 DMRTA1
DMRTA2 for paralogs About GeneDecksing
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Genomic Variantsfor DMRTA2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DMRTA2 (50883222 - 50889172 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DMRTA2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DMRTA2
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Disorders
/ Diseasesfor DMRTA2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DMRTA2 for disorders About MalaCards
DMRTA2 for disorders About GeneDecksing
OMIM gene information: 614804
OMIM disorders : --Export disorders for DMRTA2 gene to outside databases
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Publicationsfor DMRTA2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DMRTA2 gene integrated from 9 sources : (articles sorted by number of sources associating them with DMRTA2) Utopia : connect your pdf to the dynamic world of online information
Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PubMed id 11863363) 1 , 2 , 3 Ottolenghi C.... McElreavey K. (2002) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for DMRTA2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DMRTA2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DMRTA2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DMRTA2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DMRTA2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DMRTA2 gene: Search GeneIP for patents involving DMRTA2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DMRTA2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DMRTA2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DMRTA2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DMRTA2 OriGene Protein Over-expression Lysate for DMRTA2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DMRTA2 OriGene 3'-UTR Clone for DMRTA2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTA2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DMRTA2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DMRTA2 OriGene Custom Protein Services for DMRTA2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMRTA2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DMRTA2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DMRTA2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DMRTA2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DMRTA2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DMRTA2
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRTA2
ThermoFisher Antibodies for DMRTA2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DMRTA2
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