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Aliases for DMRTA1 Gene

Aliases for DMRTA1 Gene

  • DMRT-Like Family A1 2 3
  • DMRT4 3 6
  • DMO 3 4
  • Doublesex- And Mab-3-Related Transcription Factor A1 3

External Ids for DMRTA1 Gene

Previous GeneCards Identifiers for DMRTA1 Gene

  • GC09P022774
  • GC09P022647

Summaries for DMRTA1 Gene

GeneCards Summary for DMRTA1 Gene

DMRTA1 (DMRT-Like Family A1) is a Protein Coding gene. Diseases associated with DMRTA1 include colorectal cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DMRT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTA1 Gene

Genomics for DMRTA1 Gene

Regulatory Elements for DMRTA1 Gene

Genomic Location for DMRTA1 Gene

22,446,841 bp from pter
22,455,740 bp from pter
8,900 bases
Plus strand

Genomic View for DMRTA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMRTA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTA1 Gene

Proteins for DMRTA1 Gene

  • Protein details for DMRTA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublesex- and mab-3-related transcription factor A1
    Protein Accession:
    Secondary Accessions:
    • A1L481
    • Q8N8Y9
    • Q9H4B9

    Protein attributes for DMRTA1 Gene

    504 amino acids
    Molecular mass:
    53125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DMRTA1 Gene

Proteomics data for DMRTA1 Gene at MOPED

Post-translational modifications for DMRTA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRTA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMRTA1 Gene

Domains for DMRTA1 Gene

Protein Domains for DMRTA1 Gene

Suggested Antigen Peptide Sequences for DMRTA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VZB9
  • Contains 1 DM DNA-binding domain.
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTA1: view

No data available for Gene Families for DMRTA1 Gene

Function for DMRTA1 Gene

Gene Ontology (GO) - Molecular Function for DMRTA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IBA --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with DMRTA1: view
genes like me logo Genes that share phenotypes with DMRTA1: view

Animal Models for DMRTA1 Gene

MGI Knock Outs for DMRTA1:

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DMRTA1 Gene

Localization for DMRTA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTA1 Gene

Subcellular locations from

Jensen Localization Image for DMRTA1 Gene COMPARTMENTS Subcellular localization image for DMRTA1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DMRTA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DMRTA1: view

Pathways for DMRTA1 Gene

SuperPathways for DMRTA1 Gene

No Data Available

Interacting Proteins for DMRTA1 Gene

Gene Ontology (GO) - Biological Process for DMRTA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007548 sex differentiation IBA --
GO:0060179 male mating behavior IEA --
genes like me logo Genes that share ontologies with DMRTA1: view

No data available for Pathways by source for DMRTA1 Gene

Transcripts for DMRTA1 Gene

mRNA/cDNA for DMRTA1 Gene

(10) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTA1 Gene

DMRT-like family A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTA1 Gene

No ASD Table

Relevant External Links for DMRTA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DMRTA1 Gene

mRNA expression in normal human tissues for DMRTA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRTA1 Gene

This gene is overexpressed in Liver (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMRTA1 Gene

SOURCE GeneReport for Unigene cluster for DMRTA1 Gene Hs.371976

mRNA Expression by UniProt/SwissProt for DMRTA1 Gene

Tissue specificity: Expressed in liver, kidney, pancreas, prostate and weakly detected in testis and ovary.
genes like me logo Genes that share expressions with DMRTA1: view

Orthologs for DMRTA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRTA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DMRTA1 35
  • 99.01 (n)
  • 98.21 (a)
  • 98 (a)
(Bos Taurus)
Mammalia DMRTA1 35
  • 83.37 (n)
  • 80 (a)
  • 81 (a)
(Canis familiaris)
Mammalia DMRTA1 35
  • 80.71 (n)
  • 76.94 (a)
  • 78 (a)
(Mus musculus)
Mammalia Dmrta1 35
  • 77.78 (n)
  • 69.53 (a)
Dmrta1 16
Dmrta1 36
  • 69 (a)
(Monodelphis domestica)
Mammalia DMRTA1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia DMRTA1 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Dmrta1 35
  • 77.89 (n)
  • 71.1 (a)
(Anolis carolinensis)
Reptilia DMRTA1 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dmrta1 35
  • 58.33 (n)
  • 52.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta dmrt99B 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea dmd-5 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1420 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for DMRTA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DMRTA1 Gene

Gene Tree for DMRTA1 (if available)
Gene Tree for DMRTA1 (if available)

Paralogs for DMRTA1 Gene

Paralogs for DMRTA1 Gene

Selected SIMAP similar genes for DMRTA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DMRTA1: view

Variants for DMRTA1 Gene

Sequence variations from dbSNP and Humsavar for DMRTA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs510901 -- 22,449,910(+) CACTG(C/T)CTTAG intron-variant
rs538247 -- 22,450,567(+) AAATT(C/T)AGCAT intron-variant
rs558612 -- 22,447,656(+) CTGGG(A/T)GCCTT synonymous-codon, reference
rs560612 -- 22,447,908(+) CATCG(C/T)CTTCA intron-variant
rs563802 -- 22,451,032(+) TCCCT(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTA1 Gene

Variant ID Type Subtype PubMed ID
nsv892750 CNV Gain 21882294

Relevant External Links for DMRTA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTA1 Gene

Disorders for DMRTA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DMRTA1 Gene including...

Search for DMRTA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DMRTA1 Gene

Relevant External Links for DMRTA1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DMRTA1: view

No data available for UniProtKB/Swiss-Prot for DMRTA1 Gene

Publications for DMRTA1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for DMRTA1 Gene

Sources for DMRTA1 Gene

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