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Aliases for DMRT3 Gene

Aliases for DMRT3 Gene

  • Doublesex And Mab-3 Related Transcription Factor 3 2 3
  • DMRTA3 3 4 6
  • Testis-Specific Protein 2 3
  • DMRT-Like Family A3 2 3
  • Doublesex- And Mab-3-Related Transcription Factor 3 3

External Ids for DMRT3 Gene

Previous HGNC Symbols for DMRT3 Gene

  • DMRTA3

Previous GeneCards Identifiers for DMRT3 Gene

  • GC09P001143
  • GC09P000958
  • GC09P000967
  • GC09P000966

Summaries for DMRT3 Gene

GeneCards Summary for DMRT3 Gene

DMRT3 (Doublesex And Mab-3 Related Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DMRT2.

UniProtKB/Swiss-Prot for DMRT3 Gene

  • Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRT3 Gene

Genomics for DMRT3 Gene

Regulatory Elements for DMRT3 Gene

Genomic Location for DMRT3 Gene

Start:
976,964 bp from pter
End:
991,732 bp from pter
Size:
14,769 bases
Orientation:
Plus strand

Genomic View for DMRT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRT3 Gene

Proteins for DMRT3 Gene

  • Protein details for DMRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQL9-DMRT3_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor 3
    Protein Accession:
    Q9NQL9
    Secondary Accessions:
    • Q7LA03
    • Q7LCH8
    • Q96SC7
    • Q9NRQ9

    Protein attributes for DMRT3 Gene

    Size:
    472 amino acids
    Molecular mass:
    51199 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DMRT3 is a marker for a subset of spinal cord neurons (dI6)

neXtProt entry for DMRT3 Gene

Proteomics data for DMRT3 Gene at MOPED

Post-translational modifications for DMRT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMRT3 Gene

Domains for DMRT3 Gene

Protein Domains for DMRT3 Gene

Suggested Antigen Peptide Sequences for DMRT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQL9

UniProtKB/Swiss-Prot:

DMRT3_HUMAN :
  • Q9NQL9
Domain:
  • Contains 1 DM DNA-binding domain.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRT3: view

No data available for Gene Families for DMRT3 Gene

Function for DMRT3 Gene

Molecular function for DMRT3 Gene

UniProtKB/Swiss-Prot Function: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).

Gene Ontology (GO) - Molecular Function for DMRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IBA --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with DMRT3: view
genes like me logo Genes that share phenotypes with DMRT3: view

Animal Models for DMRT3 Gene

MGI Knock Outs for DMRT3:

Animal Model Products

CRISPR Products

miRNA for DMRT3 Gene

miRTarBase miRNAs that target DMRT3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DMRT3 Gene

Localization for DMRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRT3 Gene COMPARTMENTS Subcellular localization image for DMRT3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DMRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DMRT3: view

Pathways for DMRT3 Gene

SuperPathways for DMRT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DMRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007548 sex differentiation NAS 10729223
GO:0007628 adult walking behavior IBA --
GO:0019226 transmission of nerve impulse IEA --
genes like me logo Genes that share ontologies with DMRT3: view

No data available for Pathways by source for DMRT3 Gene

Transcripts for DMRT3 Gene

mRNA/cDNA for DMRT3 Gene

(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRT3 Gene

Doublesex and mab-3 related transcription factor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMRT3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DMRT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRT3 Gene

No ASD Table

Relevant External Links for DMRT3 Gene

GeneLoc Exon Structure for
DMRT3
ECgene alternative splicing isoforms for
DMRT3

Expression for DMRT3 Gene

mRNA expression in normal human tissues for DMRT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRT3 Gene

This gene is overexpressed in Testis (15.0), Thyroid (10.4), and Adipose - Subcutaneous (5.8).

SOURCE GeneReport for Unigene cluster for DMRT3 Gene Hs.189174

mRNA Expression by UniProt/SwissProt for DMRT3 Gene

Q9NQL9-DMRT3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with DMRT3: view

In Situ Assay Products

No data available for Protein expression for DMRT3 Gene

Orthologs for DMRT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMRT3 35
  • 96.54 (n)
  • 94.49 (a)
DMRT3 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMRT3 36
  • 90 (a)
OneToOne
LOC506833 35
  • 88.25 (n)
  • 90.81 (a)
dog
(Canis familiaris)
Mammalia DMRT3 36
  • 86 (a)
OneToOne
LOC609208 35
  • 82.34 (n)
  • 86.23 (a)
mouse
(Mus musculus)
Mammalia Dmrt3 35
  • 84.11 (n)
  • 90 (a)
Dmrt3 16
Dmrt3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMRT3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMRT3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmrt3 35
  • 84.4 (n)
  • 89.79 (a)
chicken
(Gallus gallus)
Aves DMRT3 35
  • 81.44 (n)
  • 87.34 (a)
DMRT3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRT3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmrt3 35
  • 71.05 (n)
  • 75.72 (a)
zebrafish
(Danio rerio)
Actinopterygii dmrt3a 35
  • 66.06 (n)
  • 68.48 (a)
dmrt3a 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dmrt93B 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dmd-11 36
  • 25 (a)
OneToMany
dmd-4 36
  • 31 (a)
OneToMany
Species with no ortholog for DMRT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMRT3 Gene

ENSEMBL:
Gene Tree for DMRT3 (if available)
TreeFam:
Gene Tree for DMRT3 (if available)

Paralogs for DMRT3 Gene

Paralogs for DMRT3 Gene

Selected SIMAP similar genes for DMRT3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DMRT3: view

Variants for DMRT3 Gene

Sequence variations from dbSNP and Humsavar for DMRT3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs166787 -- 985,334(+) TCTTA(A/G)TGTTC intron-variant
rs166788 -- 983,255(+) TACAA(C/G)AACTA intron-variant
rs169420 -- 985,371(+) AGAAA(C/G)AAGGT intron-variant
rs279877 -- 991,114(+) GACAA(A/G)GTGAC utr-variant-3-prime
rs279878 -- 988,817(+) GATCA(G/T)CTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRT3 Gene

Variant ID Type Subtype PubMed ID
nsv891954 CNV Loss 21882294
nsv892010 CNV Gain 21882294
nsv892013 CNV Gain 21882294
nsv892014 CNV Gain 21882294

Relevant External Links for DMRT3 Gene

HapMap Linkage Disequilibrium report
DMRT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRT3 Gene

Disorders for DMRT3 Gene

(1) University of Copenhagen DISEASES for DMRT3 Gene

(1) Novoseek inferred disease relationships for DMRT3 Gene

Disease -log(P) Hits PubMed IDs
gonadoblastoma 88.1 1

Relevant External Links for DMRT3

Genetic Association Database (GAD)
DMRT3
genes like me logo Genes that share disorders with DMRT3: view

No data available for UniProtKB/Swiss-Prot for DMRT3 Gene

Publications for DMRT3 Gene

  1. The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex- related domain. (PMID: 10729223) Ottolenghi C. … McElreavey K. (Genomics 2000) 2 3 4
  2. Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1. (PMID: 11543627) Brunner B. … Schartl M. (Genomics 2001) 2 3
  3. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C. … McElreavey K. (Genomics 2002) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DMRT3 Gene

Sources for DMRT3 Gene

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