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DMRT3 Gene

protein-coding   GIFtS: 50
GCID: GC09P000976

Doublesex And Mab-3 Related Transcription Factor 3

(Previous name: DMRT-like family A3)
(Previous symbol: DMRTA3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Doublesex And Mab-3 Related Transcription Factor 31 2
DMRTA31 2 3 5
DMRT-Like Family A31 2
Testis-Specific Protein1 2
Doublesex- And Mab-3-Related Transcription Factor 32

External Ids:    HGNC: 139091   Entrez Gene: 585242   Ensembl: ENSG000000642187   OMIM: 6147545   UniProtKB: Q9NQL93   

Export aliases for DMRT3 gene to outside databases

Previous GC identifers: GC09P001143 GC09P000958 GC09P000967 GC09P000966


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DMRT3 Gene:
DMRT3 (doublesex and mab-3 related transcription factor 3) is a protein-coding gene. Diseases associated with DMRT3 include gonadoblastoma, and mayer-rokitansky-kuster-hauser syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DMRT2.

UniProtKB/Swiss-Prot: DMRT3_HUMAN, Q9NQL9
Function: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in
vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the
development of a coordinated locomotor network controlling limb movements. May regulate transcription during
sexual development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMRT3 gene promoter:
         Pbx1a   MyoD   CUTL1   XBP-1   Egr-4   AREB6   SRY   S8   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMRT3 promoter sequence
   Search Chromatin IP Primers for DMRT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.3   Ensembl cytogenetic band:  9p24.3   HGNC cytogenetic band: 9p24.3

DMRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMRT3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P000976:  view genomic region     (about GC identifiers)

Start:
976,964 bp from pter      End:
991,732 bp from pter
Size:
14,769 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DMRT3_HUMAN, Q9NQL9 (See protein sequence)
Recommended Name: Doublesex- and mab-3-related transcription factor 3  
Size: 472 amino acids; 51199 Da
Developmental stage: Expressed in 4 to 5 weeks embryos
Miscellaneous: DMRT3 is a marker for a subset of spinal cord neurons (dI6)
Secondary accessions: Q7LA03 Q7LCH8 Q96SC7 Q9NRQ9

Explore the universe of human proteins at neXtProt for DMRT3: NX_Q9NQL9

Explore proteomics data for DMRT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DMRT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067063.1  
    ENSEMBL proteins: 
     ENSP00000190165   ENSP00000387472  

    DMRT3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DMRT3

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    LSBio Antibodies in human, mouse, rat for DMRT3

    DMRT3 Assay Products:

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    Cloud-Clone Corp. ELISAs for DMRT3
    Cloud-Clone Corp. CLIAs for DMRT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR009060 UBA-like
     IPR005173 DMA
     IPR026607 DMRT/dsx/mab-3
     IPR001275 DM_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9NQL9

    ProtoNet protein and cluster: Q9NQL9

    1 Blocks protein domain: IPB001275 DM DNA-binding

    UniProtKB/Swiss-Prot: DMRT3_HUMAN, Q9NQL9
    Similarity: Belongs to the DMRT family
    Similarity: Contains 1 DM DNA-binding domain


    DMRT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMRT3_HUMAN, Q9NQL9
    Function: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in
    vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the
    development of a coordinated locomotor network controlling limb movements. May regulate transcription during
    sexual development (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    DMRT3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dmrt3):
     craniofacial  mortality/aging  nervous system  reproductive system  skeleton 

    DMRT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DMRT3: Dmrt3tm1Hgc Dmrt3tm1(KOMP)Vlcg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMRT3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMRT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMRT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DMRT3:
    hsa-mir-335-5p (MIRT018492)

    Block miRNA regulation of human, mouse, rat DMRT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMRT3 (see all 21):
    hsa-miR-323-3p hsa-miR-4307 hsa-miR-137 hsa-miR-3616-5p hsa-miR-548v hsa-miR-221 hsa-miR-519a hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidDMRT3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMRT3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DMRT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DMRT3 (NM_021240)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRT3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DMRT3_HUMAN, Q9NQL9: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DMRT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMRT3
    Interactions:

        Search GeneGlobe Interaction Network for DMRT3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DMRT3 (ENSP000001901654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED29ENSP000003143434STRING: ENSP00000314343
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development ----
    GO:0007548sex differentiation NAS10729223
    GO:0007628adult walking behavior IEA--

    DMRT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMRT3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DMRT3 gene: 
    NM_021240.3  

    Unigene Cluster for DMRT3:

    Doublesex and mab-3 related transcription factor 3
    Hs.189174  [show with all ESTs]
    Unigene Representative Sequence: NM_021240
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000190165(uc003zgw.1) ENST00000417254
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DMRT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMRT3 (see all 21):
    hsa-miR-323-3p hsa-miR-4307 hsa-miR-137 hsa-miR-3616-5p hsa-miR-548v hsa-miR-221 hsa-miR-519a hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidDMRT3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DMRT3
    Predesigned siRNA for gene silencing in human, mouse, rat DMRT3
    Clone
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    OriGene ORF clones in mouse, rat for DMRT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DMRT3 (NM_021240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMRT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRT3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DMRT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMRT3
      QuantiTect SYBR Green Assays in human, mouse, rat DMRT3
      QuantiFast Probe-based Assays in human, mouse, rat DMRT3

    Additional mRNA sequence: 

    AF193873.1 AJ301581.1 BC113584.1 BC117245.1 

    1 DOTS entry:

    DT.203029 

    13 AceView cDNA sequences:

    BM980671 AA627687 NM_021240 AI052121 AF193873 AJ301581 AF217741 AI733646 
    AI732189 AW592669 AW105228 AA598944 AI002773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DMRT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGGACTC
    DMRT3 Expression
    About this image


    DMRT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
    DMRT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMRT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.189174

    UniProtKB/Swiss-Prot: DMRT3_HUMAN, Q9NQL9
    Tissue specificity: Expressed in testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DMRT3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmrt31 , 5 doublesex and mab-3 related transcription factor 31, 5 84.11(n)1
    90(a)1
      19 (20.50 cM)5
    2405901  NM_177360.31  NP_796334.21 
     256105375 
    chicken
    (Gallus gallus)
    Aves DMRT31 doublesex and mab-3 related transcription factor 3 81.44(n)
    87.34(a)
      431641  XM_429193.3  XP_429193.2 
    lizard
    (Anolis carolinensis)
    Reptilia DMRT36
    doublesex and mab-3 related transcription factor 3...
    79(a)
    1 ↔ 1
    2(50409275-50431399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dmrt31 doublesex and mab-3 related transcription factor 3 71.05(n)
    75.72(a)
      100495546  NM_001256220.2  NP_001243149.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dmrt3a1 doublesex and mab-3 related transcription factor 3a 66.06(n)
    68.48(a)
      450035  NM_001005779.2  NP_001005779.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta dmrt93B6
    doublesex-Mab related 93B
    25(a)
    1 ↔ 1
    3R(16899729-16902520)
    worm
    (Caenorhabditis elegans)
    Secernentea dmd-46
    dmd-116
    Protein DMD-11 (dmd-11) mRNA, complete cds
    31(a)
    25(a)
    1 ↔ many
    1 ↔ many
    X(14857298-14861801) WBGene00007776
    V(13236171-13236604) WBGene00007930


    ENSEMBL Gene Tree for DMRT3 (if available)
    TreeFam Gene Tree for DMRT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DMRT3 gene
    DMRT22  DMRT12  DMRTA22  DMRTA12  DMRTB12  
    1 SIMAP similar gene for DMRT3 using alignment to 2 protein entries:     DMRT3_HUMAN (see all proteins):
    DMRT2

    DMRT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DMRT3 (see all 463)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733824401,2
    C,F--975011(+) GTTAGC/TACTCG 1 -- us2k14Minor allele frequency- T:0.20WA NA CSA 124
    rs2799101,2
    C,F,A,H--975112(+) TTCAAA/GGGAAA 1 -- us2k125Minor allele frequency- G:0.36NS EA NA WA CSA 2355
    rs777703471,2
    C,F--975145(+) CAACCC/ATCCTC 1 -- us2k11Minor allele frequency- A:0.12NA 120
    rs771752441,2
    C,F--975179(+) GAGGGT/CTGGCT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1509852191,2
    --975333(+) ACATTA/GCAGCG 1 -- us2k10--------
    rs2799091,2
    C,F,A,H--975426(+) AGGCTC/TTGGAA 1 -- us2k1 tfbs315Minor allele frequency- T:0.47EA NS NA WA CSA 1980
    rs2021321031,2
    --975484(+) CTTGT-/TTTG  
            
    TTTGT
    1 -- us2k10--------
    rs1408070441,2
    --975532(+) GGGCAA/GTGGGG 1 -- us2k10--------
    rs727010851,2
    C,F--975568(+) TGTGCA/CTATAT 1 -- us2k12Minor allele frequency- C:0.16WA 120
    rs727010881,2
    C,F--975604(+) CCGCTA/CCTCCT 1 -- us2k12Minor allele frequency- C:0.15WA 120

    HapMap Linkage Disequilibrium report for DMRT3 (976964 - 991732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DMRT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891954CNV Loss21882294
    nsv892014CNV Gain21882294
    nsv892013CNV Gain21882294
    nsv892010CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DMRT3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614754    OMIM disorders: --

    9 diseases for DMRT3:    
    About MalaCards
    gonadoblastoma    mayer-rokitansky-kuster-hauser syndrome    gonadal dysgenesis    turner syndrome
    major depressive disorder    squamous cell carcinoma    cerebritis    thyroiditis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DMRT3:
    Gonadal dysgenesis

    DMRT3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DMRT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gonadoblastoma 88.1 1 9137884 (1)

    Genetic Association Database (GAD): DMRT3

    Export disorders for DMRT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DMRT3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DMRT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex- related domain. (PubMed id 10729223)1, 2, 3 Ottolenghi C.... McElreavey K. (Genomics 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PubMed id 11863363)1, 2 Ottolenghi C.... McElreavey K. (Genomics 2002)
    5. Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1. (PubMed id 11543627)1, 3 Brunner B....Schartl M. (Genomics 2001)
    6. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PubMed id 23377640)1 (Am J Psychiatry 2013)
    7. Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung. (PubMed id 20596660)1 Kang J.U....Park J.W. (Int. J. Oncol. 2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Cell-free DNA as a noninvasive acute rejection marker in renal transplantation. (PubMed id 19729469)9 GarcA-a Moreira V....Alvarez F.V. (Clin. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58524 HGNC: 13909 AceView: DMRT3 Ensembl:ENSG00000064218 euGenes: HUgn58524
    ECgene: DMRT3 H-InvDB: DMRT3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DMRT3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/154/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DMRT3 gene:
    Search GeneIP for patents involving DMRT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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