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Aliases for DMRT3 Gene

Aliases for DMRT3 Gene

  • Doublesex And Mab-3 Related Transcription Factor 3 2 3 5
  • Testis-Specific Protein 2 3
  • DMRT-Like Family A3 2 3
  • DMRTA3 3 4

External Ids for DMRT3 Gene

Previous HGNC Symbols for DMRT3 Gene

  • DMRTA3

Previous GeneCards Identifiers for DMRT3 Gene

  • GC09P001143
  • GC09P000958
  • GC09P000967
  • GC09P000966

Summaries for DMRT3 Gene

GeneCards Summary for DMRT3 Gene

DMRT3 (Doublesex And Mab-3 Related Transcription Factor 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DMRT2.

UniProtKB/Swiss-Prot for DMRT3 Gene

  • Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRT3 Gene

Genomics for DMRT3 Gene

Regulatory Elements for DMRT3 Gene

Genomic Location for DMRT3 Gene

Chromosome:
9
Start:
976,964 bp from pter
End:
991,736 bp from pter
Size:
14,773 bases
Orientation:
Plus strand

Genomic View for DMRT3 Gene

Genes around DMRT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRT3 Gene

Proteins for DMRT3 Gene

  • Protein details for DMRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQL9-DMRT3_HUMAN
    Recommended name:
    Doublesex- and mab-3-related transcription factor 3
    Protein Accession:
    Q9NQL9
    Secondary Accessions:
    • Q7LA03
    • Q7LCH8
    • Q96SC7
    • Q9NRQ9

    Protein attributes for DMRT3 Gene

    Size:
    472 amino acids
    Molecular mass:
    51199 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DMRT3 is a marker for a subset of spinal cord neurons (dI6).

neXtProt entry for DMRT3 Gene

Proteomics data for DMRT3 Gene at MOPED

Post-translational modifications for DMRT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMRT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DMRT3 Gene

Domains & Families for DMRT3 Gene

Protein Domains for DMRT3 Gene

Suggested Antigen Peptide Sequences for DMRT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQL9

UniProtKB/Swiss-Prot:

DMRT3_HUMAN :
  • Contains 1 DM DNA-binding domain.
  • Belongs to the DMRT family.
Domain:
  • Contains 1 DM DNA-binding domain.
Family:
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRT3: view

No data available for Gene Families for DMRT3 Gene

Function for DMRT3 Gene

Molecular function for DMRT3 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).

Gene Ontology (GO) - Molecular Function for DMRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with DMRT3: view
genes like me logo Genes that share phenotypes with DMRT3: view

Animal Models for DMRT3 Gene

MGI Knock Outs for DMRT3:

Animal Model Products

miRNA for DMRT3 Gene

miRTarBase miRNAs that target DMRT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMRT3 Gene

Localization for DMRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMRT3 Gene COMPARTMENTS Subcellular localization image for DMRT3 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DMRT3 Gene

Pathways & Interactions for DMRT3 Gene

SuperPathways for DMRT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DMRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007548 sex differentiation NAS 10729223
GO:0007628 adult walking behavior IEA --
GO:0042487 regulation of odontogenesis of dentin-containing tooth IEA --
genes like me logo Genes that share ontologies with DMRT3: view

No data available for Pathways by source and SIGNOR curated interactions for DMRT3 Gene

Drugs & Compounds for DMRT3 Gene

No Compound Related Data Available

Transcripts for DMRT3 Gene

mRNA/cDNA for DMRT3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRT3 Gene

Doublesex and mab-3 related transcription factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMRT3 Gene

No ASD Table

Relevant External Links for DMRT3 Gene

GeneLoc Exon Structure for
DMRT3
ECgene alternative splicing isoforms for
DMRT3

Expression for DMRT3 Gene

mRNA expression in normal human tissues for DMRT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMRT3 Gene

This gene is overexpressed in Testis (x15.0), Thyroid (x10.4), and Adipose - Subcutaneous (x5.8).

SOURCE GeneReport for Unigene cluster for DMRT3 Gene Hs.189174

mRNA Expression by UniProt/SwissProt for DMRT3 Gene

Q9NQL9-DMRT3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with DMRT3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DMRT3 Gene

Orthologs for DMRT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DMRT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC506833 35
  • 88.25 (n)
  • 90.81 (a)
DMRT3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609208 35
  • 82.34 (n)
  • 86.23 (a)
DMRT3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmrt3 35
  • 84.11 (n)
  • 90 (a)
Dmrt3 16
Dmrt3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DMRT3 35
  • 96.54 (n)
  • 94.49 (a)
DMRT3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmrt3 35
  • 84.4 (n)
  • 89.79 (a)
oppossum
(Monodelphis domestica)
Mammalia DMRT3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMRT3 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DMRT3 35
  • 81.44 (n)
  • 87.34 (a)
DMRT3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMRT3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmrt3 35
  • 71.05 (n)
  • 75.72 (a)
zebrafish
(Danio rerio)
Actinopterygii dmrt3a 35
  • 66.06 (n)
  • 68.48 (a)
dmrt3a 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dmrt93B 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dmd-11 36
  • 25 (a)
OneToMany
dmd-4 36
  • 31 (a)
OneToMany
Species with no ortholog for DMRT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMRT3 Gene

ENSEMBL:
Gene Tree for DMRT3 (if available)
TreeFam:
Gene Tree for DMRT3 (if available)

Paralogs for DMRT3 Gene

Paralogs for DMRT3 Gene

(1) SIMAP similar genes for DMRT3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DMRT3: view

Variants for DMRT3 Gene

Sequence variations from dbSNP and Humsavar for DMRT3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10978001 - 990,076(+) AGTCG(A/C/G)CAGAC reference, missense
rs7854621 - 990,368(+) CCCCA(A/C/T)CCAGA reference, missense
rs16927037 - 990,653(+) GGCTG(A/G/T)GCCTC reference, missense
rs166787 -- 985,334(+) TCTTA(A/G)TGTTC intron-variant
rs166788 -- 983,255(+) TACAA(C/G)AACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMRT3 Gene

Variant ID Type Subtype PubMed ID
nsv891954 CNV Loss 21882294
nsv892010 CNV Gain 21882294
nsv892013 CNV Gain 21882294
nsv892014 CNV Gain 21882294

Variation tolerance for DMRT3 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMRT3 Gene

HapMap Linkage Disequilibrium report
DMRT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRT3 Gene

Disorders for DMRT3 Gene

Relevant External Links for DMRT3

Genetic Association Database (GAD)
DMRT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMRT3

No disorders were found for DMRT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRT3 Gene

Publications for DMRT3 Gene

  1. The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex- related domain. (PMID: 10729223) Ottolenghi C. … McElreavey K. (Genomics 2000) 2 3 4 67
  2. Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1. (PMID: 11543627) Brunner B. … Schartl M. (Genomics 2001) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3
  5. Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung. (PMID: 20596660) Kang J.U. … Park J.W. (Int. J. Oncol. 2010) 3

Products for DMRT3 Gene

Sources for DMRT3 Gene

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