Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DMRT2 Gene

protein-coding   GIFtS: 50
GCID: GC09P001050

Doublesex And Mab-3 Related Transcription Factor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Doublesex And Mab-3 Related Transcription Factor 21 2
Terra-Like Protein1 2
Doublesex-Like 2 Protein2 3
DSXL-22 3
Doublesex- And Mab-3-Related Transcription Factor 22
DSXL23

External Ids:    HGNC: 29351   Entrez Gene: 106552   Ensembl: ENSG000001732537   OMIM: 6049355   UniProtKB: Q9Y5R53   

Export aliases for DMRT2 gene to outside databases

Previous GC identifers: GC09P001216 GC09P001031 GC09P001040 GC09P001003


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DMRT2 Gene:
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila
'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is
located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex
reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. (provided by RefSeq, Apr
2010)

GeneCards Summary for DMRT2 Gene: 
DMRT2 (doublesex and mab-3 related transcription factor 2) is a protein-coding gene. Diseases associated with DMRT2 include gonadal dysgenesis, and attention deficit hyperactivity disorder. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DMRT3.

UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5
Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene
MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in
somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome.
Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DMRT2 gene promoter:
         HOXA9   HOXA9B   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   POU3F2   Meis-1b   Pax-3   POU2F1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMRT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DMRT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMRT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.3   Ensembl cytogenetic band:  9p24.3   HGNC cytogenetic band: 9p24.3

DMRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMRT2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P001050:  view genomic region     (about GC identifiers)

Start:
1,050,346 bp from pter      End:
1,057,554 bp from pter
Size:
7,209 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5 (See protein sequence)
Recommended Name: Doublesex- and mab-3-related transcription factor 2  
Size: 561 amino acids; 61814 Da
Subunit: Homodimer (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: B1ANC0 B9EGJ1 Q9NPG6 Q9NQR6
Alternative splicing: 3 isoforms:  Q9Y5R5-1   Q9Y5R5-2   Q9Y5R5-3   (Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224)

Explore the universe of human proteins at neXtProt for DMRT2: NX_Q9Y5R5

Explore proteomics data for DMRT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5R5

  • DMRT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DMRT2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001124337.1  NP_006548.1  NP_870987.2  

    ENSEMBL proteins: 
     ENSP00000371690   ENSP00000397494   ENSP00000350865   ENSP00000259622   ENSP00000371686  
     ENSP00000305785  

    Human Recombinant Protein Products for DMRT2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DMRT2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DMRT2
    GenScript Custom Purified and Recombinant Proteins Services for DMRT2
    Novus Biologicals DMRT2 Protein
    Novus Biologicals DMRT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DMRT2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    DMRT2 for ontologies           About GeneDecksing



    DMRT2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DMRT2
    GenScript Custom Superior Antibodies Services for DMRT2
    Novus Biologicals DMRT2 Antibodies
    Abcam antibodies for DMRT2
    Cloud-Clone Corp. Antibodies for DMRT2 
    Search ThermoFisher Antibodies for DMRT2
    LSBio Antibodies in human, mouse, rat for DMRT2 

    Assay Products for DMRT2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DMRT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DMRT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DMRT2 
    Cloud-Clone Corp. CLIAs for DMRT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026607 DMRT/dsx/mab-3
     IPR001275 DM_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y5R5

    ProtoNet protein and cluster: Q9Y5R5

    1 Blocks protein domain: IPB001275 DM DNA-binding

    UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5
    Similarity: Belongs to the DMRT family
    Similarity: Contains 1 DM DNA-binding domain


    DMRT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMRT2_HUMAN, Q9Y5R5
    Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene
    MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in
    somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome.
    Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome
    (By similarity)

         Genatlas biochemistry entry for DMRT2:
    double sex (Drosophila) and MAB-3 (C elegans) related transcription factor 2,specifically expressed in the
    testis,involved in testis development

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    DMRT2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dmrt2):
     craniofacial  embryogenesis  limbs/digits/tail  mortality/aging  muscle 
     reproductive system  respiratory system  skeleton 

    DMRT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dmrt2tm1Rjo for DMRT2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DMRT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DMRT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMRT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMRT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DMRT2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DMRT2:
    hsa-miR-203 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidDMRT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DMRT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DMRT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DMRT2
    Sirion Biotech Customized adenovirus for overexpression of DMRT2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DMRT2 (see all 13)
    OriGene ORF clones in mouse, rat for DMRT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DMRT2 (NM_001130865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRT2
    Sirion Biotech Customized lentivirus for stable overexpression of DMRT2 
                         Customized lentivirus expression plasmids for stable overexpression of DMRT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DMRT2
    Search LifeMap BioReagents cell lines for DMRT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DMRT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for DMRT2 (Q9Y5R53 ENSP000003057854) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RPS3ENSP000002785724STRING: ENSP00000278572
    CCDC18ENSP000003340844STRING: ENSP00000334084
    MYBBP1AENSP000003709684STRING: ENSP00000370968
    BCLAF1ENSP000000311354STRING: ENSP00000031135
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007530sex determination TAS10332030
    GO:0008150biological_process ND--
    GO:0008584male gonad development TAS10332030

    DMRT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DMRT2

    Search CenterWatch for drugs/clinical trials and news about DMRT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DMRT2 gene (3 alternative transcripts): 
    NM_001130865.2  NM_006557.6  NM_181872.4  

    Unigene Cluster for DMRT2:

    Doublesex and mab-3 related transcription factor 2
    Hs.59506  [show with all ESTs]
    Unigene Representative Sequence: NM_006557
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382255(uc011llt.2 uc022bcw.1) ENST00000412350 ENST00000358146
    ENST00000259622(uc003zhb.4) ENST00000382251(uc003zgy.4) ENST00000302441(uc003zha.3 uc011llv.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DMRT2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DMRT2:
    hsa-miR-203 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidDMRT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DMRT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DMRT2
    Clone
    Products:
         
    OriGene clones in human, mouse for DMRT2 (see all 13)
    OriGene ORF clones in mouse, rat for DMRT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DMRT2 (NM_001130865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRT2
    Sirion Biotech Customized lentivirus for stable overexpression of DMRT2 
                         Customized lentivirus expression plasmids for stable overexpression of DMRT2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DMRT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DMRT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRT2

    Additional mRNA sequence: 

    AF130729.1 AF284221.1 AF284222.1 AF284223.1 AF284224.1 AF284225.1 BC030204.1 BC136493.1 
    BX647565.1 Y19052.1 

    3 DOTS entries:

    DT.95266802  DT.75114236  DT.210001 

    24/38 AceView cDNA sequences (see all 38):

    AI298138 AA886770 AA771859 BX107686 AF284224 BC030204 AI093205 NM_181872 
    AL598943 AF284225 AF284223 NM_006557 AF284221 BX280236 Y19052 AI814402 
    AW418913 W93861 AF130729 AF284222 AA938275 AI264251 AI302907 AW468875 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DMRT2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                            
    SP2:                                                  -         
    SP3:        -                                                   
    SP4:                                            -     -         


    ECgene alternative splicing isoforms for DMRT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DMRT2 expression in normal human tissues (normalized intensities)      DMRT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTTTTCT
    DMRT2 Expression
    About this image


    DMRT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             Human Skeletal Muscle Satellite Cells (HSkMSC)   
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud

    See DMRT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DMRT2

    SOURCE GeneReport for Unigene cluster: Hs.59506

    UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5
    Tissue specificity: Expressed in testis, kidney and skeletal muscle

        SABiosciences Custom PCR Arrays for DMRT2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DMRT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DMRT2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRT2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DMRT2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmrt21 , 5 doublesex and mab-3 related transcription factor 21, 5 83.9(n)1
    83.78(a)1
      19 (20.53 cM)5
    2260491  NM_145831.31  NP_665830.11 
     256724115 
    chicken
    (Gallus gallus)
    Aves DMRT21 doublesex and mab-3 related transcription factor 2 76.07(n)
    74.69(a)
      100858556  XM_003642987.1  XP_003643035.1 
    lizard
    (Anolis carolinensis)
    Reptilia DMRT26
    Uncharacterized protein
    66(a)
    1 ↔ 1
    2(50471220-50486610)
    zebrafish
    (Danio rerio)
    Actinopterygii dmrt22 doublesex and mab-3 related transcription factor 2 79.64(n)   30129  AF080622.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dmrt11E6
    doublesex-Mab related 11E
    20(a)
    1 ↔ 1
    X(13262224-13264505)


    ENSEMBL Gene Tree for DMRT2 (if available)
    TreeFam Gene Tree for DMRT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DMRT2 gene
    DMRT32  DMRT12  DMRTA22  DMRTA12  DMRTB12  
    5 SIMAP similar genes for DMRT2 using alignment to 2 protein entries:     DMRT2_HUMAN (see all proteins):
    DKFZp313M1824    DMRT3    DMRTA2    DMRTC2    DMRTA1

    DMRT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/325 SNPs in DMRT2 are shown (see all 325)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122852381,2
    C,F--1043289(+) TAACCT/GTAAAA 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs22799851,2
    C,F,A--1043313(-) CTGGGT/CTTTTA 2 -- us2k110Minor allele frequency- C:0.47EA NA WA CSA 1856
    rs22799841,2
    C,F,A,H--1043407(-) ATTTCT/AGCCTT 2 -- us2k126Minor allele frequency- A:0.46EA MN NS NA WA CSA 4038
    rs759214831,2
    C,F--1043456(+) TTGATA/GAAAAC 2 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1386947501,2
    --1043476(+) CCTGTA/TACAGG 2 -- us2k10--------
    rs1417773891,2
    --1043512(+) ACTCAA/CATCAG 2 -- us2k10--------
    rs1161914241,2
    C--1043554(+) CAAACC/TCATGG 3 -- us2k10--------
    rs1833189491,2
    --1043593(+) TCTGCA/CAAATT 3 -- us2k10--------
    rs749341691,2
    C,F--1043607(+) GGGACT/GTCAGA 3 -- us2k12Minor allele frequency- G:0.09CSA WA 120
    rs1147690261,2
    F--1043640(+) GCTCTT/CCCCGA 3 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for DMRT2 (1050346 - 1057554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DMRT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv891954CNV Loss21882294
    nsv892010CNV Gain21882294
    dgv8005n71CNV Gain21882294
    dgv2273e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DMRT2
    DNA2.0 Custom Variant and Variant Library Synthesis for DMRT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604935    OMIM disorders: --

    6 diseases for DMRT2:    About MalaCards
    gonadal dysgenesis    attention deficit hyperactivity disorder    fanconi's anemia    chronic lymphocytic leukemia
    anemia    leukemia


    DMRT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DMRT2

    Export disorders for DMRT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DMRT2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DMRT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. (PubMed id 10332030)1, 2, 3 Raymond C.S.... Zarkower D. (1999)
    2. A new submicroscopic deletion that refines the 9p region for sex reversal. (PubMed id 10857744)1, 2, 9 Calvari V.... Guioli S. (2000)
    3. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (2008)
    4. The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript. (PubMed id 10729224)1, 2 Ottolenghi C.... McElreavey K. (2000)
    5. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1 Dolmans G.H.... . (2011)
    6. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    7. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10655 HGNC: 2935 AceView: DMRT2 Ensembl:ENSG00000173253 euGenes: HUgn10655
    ECgene: DMRT2 H-InvDB: DMRT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DMRT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DMRT2 gene:
    Search GeneIP for patents involving DMRT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DMRT2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DMRT2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DMRT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DMRT2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DMRT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DMRT2   OriGene Custom Protein Services for DMRT2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DMRT2
     QIAGEN SeqTarget long-range PCR primers for resequencing DMRT2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMRT2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DMRT2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMRT2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMRT2
     GenScript Custom Purified and Recombinant Proteins Services for DMRT2 GenScript cDNA clones with any tag delivered in your preferred vector for DMRT2
     GenScript Custom Assay Services for DMRT2 GenScript Custom Superior Antibodies Services for DMRT2
     GenScript Custom overexpressing Cell Line Services for DMRT2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DMRT2 promoter
     Search Chromatin IP Primers for DMRT2
     RT2 qPCR Primer Assay in human, mouse, rat DMRT2
     Search GNC Networks for DMRT2
     SABiosciences Custom PCR Arrays for DMRT2
     Search Tocris compounds for DMRT2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DMRT2 antibodies
     DMRT2 proteins
     DMRT2 lysates
     Antibodies for DMRT2
     See all of Abcam's Antibodies, Kits and Proteins for DMRT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DMRT2
     Antibodies for DMRT2
     ELISAs for DMRT2
     CLIAs for DMRT2
     Search LifeMap BioReagents cell lines for DMRT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRT2
     SwitchGear 3'UTR luciferase reporter plasmids for DMRT2
     SwitchGear Promoter luciferase reporter plasmids for DMRT2
     Search ThermoFisher Antibodies for DMRT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRT2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DMRT2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DMRT2
    Customized:
     lentivirus for stable overexpression of DMRT2
     lentivirus expression plasmids for stable overexpression of DMRT2
     adenovirus for overexpression of DMRT2
     LSBio Antibodies in human, mouse, rat for DMRT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DMRT2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4