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DMRT2 Gene

protein-coding   GIFtS: 50
GCID: GC09P001050

Doublesex And Mab-3 Related Transcription Factor 2

  See DMRT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Doublesex And Mab-3 Related Transcription Factor 21 2
Terra-Like Protein1 2
Doublesex-Like 2 Protein2 3
DSXL-22 3
Doublesex- And Mab-3-Related Transcription Factor 22
DSXL23

External Ids:    HGNC: 29351   Entrez Gene: 106552   Ensembl: ENSG000001732537   OMIM: 6049355   UniProtKB: Q9Y5R53   

Export aliases for DMRT2 gene to outside databases

Previous GC identifers: GC09P001216 GC09P001031 GC09P001040 GC09P001003


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DMRT2 Gene:
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila
'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is
located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex
reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. (provided by RefSeq, Apr
2010)

GeneCards Summary for DMRT2 Gene:
DMRT2 (doublesex and mab-3 related transcription factor 2) is a protein-coding gene. Diseases associated with DMRT2 include 46xy sex reversal 6. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DMRT3.

UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5
Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene
MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in
somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome.
Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMRT2 gene promoter:
         HOXA9   HOXA9B   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   POU3F2   Meis-1b   Pax-3   POU2F1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMRT2 promoter sequence
   Search Chromatin IP Primers for DMRT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMRT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.3   Ensembl cytogenetic band:  9p24.3   HGNC cytogenetic band: 9p24.3

DMRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMRT2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P001050:  view genomic region     (about GC identifiers)

Start:
1,050,346 bp from pter      End:
1,057,554 bp from pter
Size:
7,209 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5 (See protein sequence)
Recommended Name: Doublesex- and mab-3-related transcription factor 2  
Size: 561 amino acids; 61814 Da
Subunit: Homodimer (By similarity)
Secondary accessions: B1ANC0 B9EGJ1 Q9NPG6 Q9NQR6
Alternative splicing: 3 isoforms:  Q9Y5R5-1   Q9Y5R5-2   Q9Y5R5-3   (Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224)

Explore the universe of human proteins at neXtProt for DMRT2: NX_Q9Y5R5

Explore proteomics data for DMRT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DMRT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124337.1  NP_006548.1  NP_870987.2  

    ENSEMBL proteins: 
     ENSP00000371690   ENSP00000397494   ENSP00000350865   ENSP00000259622   ENSP00000371686  
     ENSP00000305785  

    DMRT2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026607 DMRT/dsx/mab-3
     IPR001275 DM_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y5R5

    ProtoNet protein and cluster: Q9Y5R5

    1 Blocks protein domain: IPB001275 DM DNA-binding

    UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5
    Similarity: Belongs to the DMRT family
    Similarity: Contains 1 DM DNA-binding domain


    Find genes that share domains with DMRT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMRT2_HUMAN, Q9Y5R5
    Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene
    MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in
    somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome.
    Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome
    (By similarity)

         Genatlas biochemistry entry for DMRT2:
    double sex (Drosophila) and MAB-3 (C elegans) related transcription factor 2,specifically expressed in the
    testis,involved in testis development

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DMRT2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dmrt2):
     craniofacial  embryogenesis  limbs/digits/tail  mortality/aging  muscle 
     reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with DMRT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dmrt2tm1Rjo for DMRT2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMRT2
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    miRNA
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    miRTarBase miRNAs that target DMRT2:
    hsa-mir-148b-3p (MIRT019316)

    Block miRNA regulation of human, mouse, rat DMRT2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DMRT2:
    hsa-miR-203 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidDMRT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMRT2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMRT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DMRT2_HUMAN, Q9Y5R5: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with DMRT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMRT2
    Interactions:

        Search GeneGlobe Interaction Network for DMRT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DMRT2 (Q9Y5R53 ENSP000003057854) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CCDC18ENSP000003340844STRING: ENSP00000334084
    DDX21ENSP000003461204STRING: ENSP00000346120
    FXR1ENSP000003501704STRING: ENSP00000350170
    FXR2ENSP000002501134STRING: ENSP00000250113
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007530sex determination TAS10332030
    GO:0008150biological_process ND--
    GO:0008584male gonad development TAS10332030

    Find genes that share ontologies with DMRT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMRT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DMRT2 gene (3 alternative transcripts): 
    NM_001130865.2  NM_006557.6  NM_181872.4  

    Unigene Cluster for DMRT2:

    Doublesex and mab-3 related transcription factor 2
    Hs.59506  [show with all ESTs]
    Unigene Representative Sequence: NM_006557
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382255(uc011llt.2 uc022bcw.1) ENST00000412350 ENST00000358146
    ENST00000259622(uc003zhb.4) ENST00000382251(uc003zgy.4) ENST00000302441(uc003zha.3 uc011llv.2)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DMRT2:
    hsa-miR-203 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidDMRT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMRT2
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    GenScript: all cDNA clones in your preferred vector (see all 3): DMRT2 (NM_001130865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMRT2
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    OriGene qSTAR qPCR primer pairs in human, mouse for DMRT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMRT2
      QuantiTect SYBR Green Assays in human, mouse, rat DMRT2
      QuantiFast Probe-based Assays in human, mouse, rat DMRT2

    Additional mRNA sequence: 

    AF130729.1 AF284221.1 AF284222.1 AF284223.1 AF284224.1 AF284225.1 BC030204.1 BC136493.1 
    BX647565.1 Y19052.1 

    3 DOTS entries:

    DT.95266802  DT.75114236  DT.210001 

    Selected AceView cDNA sequences (see all 38):

    AA886770 AI298138 AA771859 BX107686 BC030204 AF284224 AI093205 AA625259 
    AF130729 Y19052 NM_006557 AL598943 AI302907 AF284221 NM_181872 AF284225 
    BX280236 AI814402 AF284223 AW418913 W93861 AF284222 AI264251 AA938275 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DMRT2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                            
    SP2:                                                  -         
    SP3:        -                                                   
    SP4:                                            -     -         


    ECgene alternative splicing isoforms for DMRT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DMRT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTTTTCT
    DMRT2 Expression
    About this image


    DMRT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    DMRT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMRT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59506

    UniProtKB/Swiss-Prot: DMRT2_HUMAN, Q9Y5R5
    Tissue specificity: Expressed in testis, kidney and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DMRT2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmrt21 , 5 doublesex and mab-3 related transcription factor 21, 5 83.9(n)1
    83.78(a)1
      19 (20.53 cM)5
    2260491  NM_145831.31  NP_665830.11 
     256724115 
    chicken
    (Gallus gallus)
    Aves DMRT21 doublesex and mab-3 related transcription factor 2 75.25(n)
    73.23(a)
      100858556  XM_003642987.2  XP_003643035.2 
    lizard
    (Anolis carolinensis)
    Reptilia DMRT26
    doublesex and mab-3 related transcription factor 2...
    66(a)
    1 ↔ 1
    2(50471220-50486610)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dmrt21 doublesex and mab-3 related transcription factor 2 66.33(n)
    66.47(a)
      100101749  NM_001100256.1  NP_001093726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dmrt22 doublesex and mab-3 related transcription factor 2 79.64(n)   30129  AF080622.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dmrt11E6
    doublesex-Mab related 11E
    23(a)
    1 ↔ 1
    X(13262224-13264505)
    worm
    (Caenorhabditis elegans)
    Secernentea dmd-36
    Protein DMD-3, isoform a
    24(a)
    many ↔ many
    V(19650438-19655251) WBGene00012832


    ENSEMBL Gene Tree for DMRT2 (if available)
    TreeFam Gene Tree for DMRT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DMRT2 gene
    DMRT32  DMRT12  DMRTA22  DMRTA12  DMRTB12  
    5 SIMAP similar genes for DMRT2 using alignment to 2 protein entries:     DMRT2_HUMAN (see all proteins):
    DKFZp313M1824    DMRT3    DMRTA2    DMRTC2    DMRTA1

    Find genes that share paralogs with DMRT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DMRT2 (see all 325)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122852381,2
    C,F--1043289(+) TAACCT/GTAAAA 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs22799851,2
    C,F,A--1043313(-) CTGGGT/CTTTTA 2 -- us2k110Minor allele frequency- C:0.47EA NA WA CSA 1856
    rs22799841,2
    C,F,A,H--1043407(-) ATTTCT/AGCCTT 2 -- us2k126Minor allele frequency- A:0.46EA MN NS NA WA CSA 4038
    rs759214831,2
    C,F--1043456(+) TTGATA/GAAAAC 2 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1386947501,2
    --1043476(+) CCTGTA/TACAGG 2 -- us2k10--------
    rs1417773891,2
    --1043512(+) ACTCAA/CATCAG 2 -- us2k10--------
    rs1161914241,2
    C--1043554(+) CAAACC/TCATGG 3 -- us2k10--------
    rs1833189491,2
    --1043593(+) TCTGCA/CAAATT 3 -- us2k10--------
    rs749341691,2
    C,F--1043607(+) GGGACT/GTCAGA 3 -- us2k12Minor allele frequency- G:0.09CSA WA 120
    rs1147690261,2
    F--1043640(+) GCTCTT/CCCCGA 3 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for DMRT2 (1050346 - 1057554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DMRT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891954CNV Loss21882294
    nsv892010CNV Gain21882294
    dgv8005n71CNV Gain21882294
    dgv2273e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604935    OMIM disorders: --

    1 disease for DMRT2:    
    About MalaCards
    46xy sex reversal 6


    Find genes that share disorders with DMRT2           About GenesLikeMe

    Genetic Association Database (GAD): DMRT2

    Export disorders for DMRT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DMRT2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with DMRT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. (PubMed id 10332030)1, 2, 3 Raymond C.S.... Zarkower D. (Hum. Mol. Genet. 1999)
    2. A new submicroscopic deletion that refines the 9p region for sex reversal. (PubMed id 10857744)1, 2, 9 Calvari V.... Guioli S. (Genomics 2000)
    3. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    4. The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript. (PubMed id 10729224)1, 2 Ottolenghi C.... McElreavey K. (Genomics 2000)
    5. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1 Dolmans G.H.... . (N. Engl. J. Med. 2011)
    6. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (Blood 2009)
    7. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10655 HGNC: 2935 AceView: DMRT2 Ensembl:ENSG00000173253 euGenes: HUgn10655
    ECgene: DMRT2 H-InvDB: DMRT2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DMRT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DMRT2 gene:
    Search GeneIP for patents involving DMRT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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