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Aliases for DMP1 Gene

Aliases for DMP1 Gene

  • Dentin Matrix Acidic Phosphoprotein 1 2 3
  • Dentin Matrix Protein 1 3 4
  • DMP-1 3 4
  • ARHP 3 6
  • ARHR 3 6
  • Dentin Matrix Acidic Phosphoprotein 2

External Ids for DMP1 Gene

Previous GeneCards Identifiers for DMP1 Gene

  • GC04P088729
  • GC04P088873
  • GC04P089029
  • GC04P088928
  • GC04P088571
  • GC04P084317

Summaries for DMP1 Gene

Entrez Gene Summary for DMP1 Gene

  • Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DMP1 Gene

DMP1 (Dentin Matrix Acidic Phosphoprotein 1) is a Protein Coding gene. Diseases associated with DMP1 include hypophosphatemic rickets, ar and autosomal recessive hypophosphatemic rickets. Among its related pathways are Degradation of the extracellular matrix and ECM proteoglycans. GO annotations related to this gene include calcium ion binding and extracellular matrix binding.

UniProtKB/Swiss-Prot for DMP1 Gene

  • May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.

Gene Wiki entry for DMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMP1 Gene

Genomics for DMP1 Gene

Regulatory Elements for DMP1 Gene

Genomic Location for DMP1 Gene

Start:
87,650,302 bp from pter
End:
87,664,361 bp from pter
Size:
14,060 bases
Orientation:
Plus strand

Genomic View for DMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMP1 Gene

Proteins for DMP1 Gene

  • Protein details for DMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13316-DMP1_HUMAN
    Recommended name:
    Dentin matrix acidic phosphoprotein 1
    Protein Accession:
    Q13316
    Secondary Accessions:
    • A1L4L3
    • O43265

    Protein attributes for DMP1 Gene

    Size:
    513 amino acids
    Molecular mass:
    55782 Da
    Quaternary structure:
    • Interacts with importin alpha.

    Alternative splice isoforms for DMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMP1 Gene

Proteomics data for DMP1 Gene at MOPED

Post-translational modifications for DMP1 Gene

  • Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.
  • Glycosylation at Asn25, Asn285, Asn324, Asn345, Asn351, Asn413, Asn426, and Asn467
  • Modification sites at PhosphoSitePlus

Other Protein References for DMP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DMP1 Gene

Domains for DMP1 Gene

Protein Domains for DMP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DMP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DMP1 Gene

Function for DMP1 Gene

Molecular function for DMP1 Gene

GENATLAS Biochemistry: dentin matrix acidic phosphoprotein 1
UniProtKB/Swiss-Prot Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.

Gene Ontology (GO) - Molecular Function for DMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 8509401
GO:0005509 calcium ion binding TAS 8509401
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with DMP1: view
genes like me logo Genes that share phenotypes with DMP1: view

Animal Models for DMP1 Gene

MGI Knock Outs for DMP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DMP1 Gene

Localization for DMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMP1 Gene

Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMP1 Gene COMPARTMENTS Subcellular localization image for DMP1 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with DMP1: view

Pathways for DMP1 Gene

genes like me logo Genes that share pathways with DMP1: view

Pathways by source for DMP1 Gene

2 Reactome pathways for DMP1 Gene

Gene Ontology (GO) - Biological Process for DMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0031214 biomineral tissue development IEA --
genes like me logo Genes that share ontologies with DMP1: view

Compounds for DMP1 Gene

(1) HMDB Compounds for DMP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) Novoseek inferred chemical compound relationships for DMP1 Gene

Compound -log(P) Hits PubMed IDs
rgd peptide 66.2 2
hydroxyapatite 54.5 12
miltefosine 46.5 3
vitamin d 33.7 2
matrigel 27.3 1
genes like me logo Genes that share compounds with DMP1: view

Transcripts for DMP1 Gene

mRNA/cDNA for DMP1 Gene

(8) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMP1 Gene

Dentin matrix acidic phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMP1 Gene

No ASD Table

Relevant External Links for DMP1 Gene

GeneLoc Exon Structure for
DMP1
ECgene alternative splicing isoforms for
DMP1

Expression for DMP1 Gene

mRNA expression in normal human tissues for DMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMP1 Gene

This gene is overexpressed in Testis (19.8) and Artery - Tibial (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMP1 Gene

SOURCE GeneReport for Unigene cluster for DMP1 Gene Hs.652366

mRNA Expression by UniProt/SwissProt for DMP1 Gene

Q13316-DMP1_HUMAN
Tissue specificity: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast
genes like me logo Genes that share expressions with DMP1: view

In Situ Assay Products

Orthologs for DMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMP1 35
  • 98.77 (n)
  • 97.66 (a)
DMP1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMP1 35
  • 77.62 (n)
  • 70.67 (a)
DMP1 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMP1 35
  • 81.36 (n)
  • 75.2 (a)
DMP1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmp1 35
  • 72.49 (n)
  • 64.26 (a)
Dmp1 16
Dmp1 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMP1 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMP1 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmp1 35
  • 73.31 (n)
  • 65.15 (a)
lizard
(Anolis carolinensis)
Reptilia DMP1 36
  • 26 (a)
OneToOne
Species with no ortholog for DMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMP1 Gene

ENSEMBL:
Gene Tree for DMP1 (if available)
TreeFam:
Gene Tree for DMP1 (if available)

Paralogs for DMP1 Gene

No data available for Paralogs for DMP1 Gene

Variants for DMP1 Gene

Sequence variations from dbSNP and Humsavar for DMP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1381634 -- 87,652,448(+) GCTTA(A/C)AGTTG intron-variant
rs1462366 -- 87,649,340(+) CAGTA(A/G)ACAAG upstream-variant-2KB
rs1462367 -- 87,649,376(+) TAAGG(C/T)CCAGC upstream-variant-2KB
rs1462368 -- 87,649,647(+) CAAAC(A/G)GGGAA upstream-variant-2KB
rs1462369 -- 87,650,704(+) TAATT(A/G)GCAAA intron-variant

Relevant External Links for DMP1 Gene

HapMap Linkage Disequilibrium report
DMP1
Human Gene Mutation Database (HGMD)
DMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DMP1 Gene

Disorders for DMP1 Gene

(1) OMIM Diseases for DMP1 Gene (600980)

UniProtKB/Swiss-Prot

DMP1_HUMAN
  • Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1) [MIM:241520]: A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. {ECO:0000269 PubMed:17033621, ECO:0000269 PubMed:17033625}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for DMP1 Gene

(12) Novoseek inferred disease relationships for DMP1 Gene

Disease -log(P) Hits PubMed IDs
dgi-ii 95.3 2
dentinogenesis imperfecta 92 6
rickets hypophosphatemic 84.2 5
hypophosphatemia 74.6 5
osteomalacia 71.4 3

Relevant External Links for DMP1

Genetic Association Database (GAD)
DMP1
Human Genome Epidemiology (HuGE) Navigator
DMP1
genes like me logo Genes that share disorders with DMP1: view

Publications for DMP1 Gene

  1. Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21. (PMID: 8586437) Aplin H.M. … Dixon M.J. (Genomics 1995) 2 3 4 23
  2. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. (PMID: 9177774) Hirst K.L. … McDougall M. (Genomics 1997) 2 3 4 23
  3. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. (PMID: 12615915) Narayanan K. … George A. (J. Biol. Chem. 2003) 3 4 23
  4. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. (PMID: 17033625) Lorenz-Depiereux B. … Strom T.M. (Nat. Genet. 2006) 3 4 23
  5. Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. (PMID: 16679514) Narayanan K. … George A. (J. Biol. Chem. 2006) 3 23

Products for DMP1 Gene

Sources for DMP1 Gene

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