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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DMP1 Gene

protein-coding   GIFtS: 56
GCID: GC04P088571

dentin matrix acidic phosphoprotein 1

(Previous name: dentin matrix acidic phosphoprotein )
 Explore 23 diseases affiliated with
DMP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DMP1    

Aliases
for DMP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dentin Matrix Acidic Phosphoprotein 11 2
Dentin Matrix Protein 12 3
DMP-12 3
ARHP2 5
ARHR2 5
Dentin Matrix Acidic Phosphoprotein1

External Ids:    HGNC: 29321   Entrez Gene: 17582   Ensembl: ENSG000001525927   OMIM: 6009805   UniProtKB: Q133163   

Export aliases for DMP1 gene to outside databases

Previous GC identifers: GC04P088729 GC04P088873 GC04P089029 GC04P088928 GC04P084317


Summaries
for DMP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DMP1:
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding
ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is
present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple
phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In
undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific
genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix,
where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive
hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals.
Two transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts,
unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like
osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the
extracellular matrix, where it regulates nucleation of hydroxyapatite

Gene Wiki entry for DMP1


Genomic Views
for DMP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DMP1 gene promoter:
         AML1a   AP-1   p53   ATF-2   YY1   PPAR-gamma1   Chx10   c-Jun   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21

DMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088571:  view genomic region     (about GC identifiers)

Start:
 88,571,454 bp from pter      End:
 88,585,513 bp from pter
Size:
 14,060 bases      Orientation:
 plus strand

Proteins
for DMP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316 (See protein sequence)
Recommended Name: Dentin matrix acidic phosphoprotein 1 precursor  
Size: 513 amino acids; 55782 Da
Subunit: Interacts with importin alpha
Subcellular location: Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating
preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the
mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from
intracellular stores followed by a massive influx of this pool of calcium into the nucleus
Secondary accessions: A1L4L3 O43265
Alternative splicing: 2 isoforms:  Q13316-1   Q13316-2   

Explore the universe of human proteins at neXtProt for DMP1: NX_Q13316

Post-translational modifications:

  • Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is
    • necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by
    calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13316

    • DMP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073380.1  NP_004398.1  

    ENSEMBL proteins: 
     ENSP00000340935   ENSP00000282479  

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    Uscn Proteins for DMP1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    DMP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DMP1

    Protein Domains /
    Families
    for DMP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DMP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009889 DMP1

    Graphical View of Domain Structure for InterPro Entry Q13316

    ProtoNet protein and cluster: Q13316

    1 Blocks protein family: IPB009889 Dentin matrix 1


    Function
    for DMP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
    Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts,
    unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like
    osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the
    extracellular matrix, where it regulates nucleation of hydroxyapatite

         Genatlas biochemistry entry for DMP1:
    dentin matrix acidic phosphoprotein 1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DMP1
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    hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-515-5p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: DMP1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DMP1
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS8509401
    GO:0005509calcium ion binding TAS8509401
    GO:0050840extracellular matrix binding IEA--


    DMP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DMP1:
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Dmp1tm1.1Mis for DMP1
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dmp1):
     craniofacial  limbs/digits/tail  no phenotypic analysis  skeleton 

    DMP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DMP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DMP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DMP1 (Q133163 ENSP000003409354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD44P160703, ENSP000002783854I2D: score=1 STRING: ENSP00000278385
    CFHP086033, ENSP000003563994I2D: score=1 STRING: ENSP00000356399
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization IEA--
    GO:0031214biomineral tissue development IEA--


    DMP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DMP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DMP1

    1 HMDB Compound for DMP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    6 Novoseek chemical compound relationships for DMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rgd peptide 66.2 3 16995818 (1), 16357164 (1)
    hydroxyapatite 54.5 25 16331974 (4), 17052984 (2), 12615915 (1), 20200415 (1) (see all 8)
    miltefosine 46.5 4 19836718 (1), 19951713 (1), 20113781 (1)
    vitamin d 33.7 4 19121771 (1), 19007919 (1)
    matrigel 27.3 1 16357164 (1)
    calcium 7.54 10 12872163 (1), 18085632 (1)

    Search CenterWatch for drugs/clinical trials and news about DMP1 

    Transcripts
    for DMP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DMP1 gene (2 alternative transcripts): 
    NM_001079911.2  NM_004407.3  

    Unigene Cluster for DMP1:

    Dentin matrix acidic phosphoprotein 1
    Hs.652366  [show with all ESTs]
    Unigene Representative Sequence: NM_004407
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339673(uc003hqv.3) ENST00000282479(uc003hqw.3)

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DMP1 (see all 23):
    hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-515-5p hsa-let-7a
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    Inhib. RNA
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    OriGene shRNA RFP: DMP1
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    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMP1

    Additional cDNA sequence: 

    BC130581.1 BC132865.1 U65378.1 U89012.1 

    2 DOTS entries:

    DT.95254636  DT.309049 

    8 AceView cDNA sequences:

    U89012 BQ447431 U65378 CA428759 AA297032 AI371158 NM_004407 H89203 

    GeneLoc Exon Structure


    Expression
    for DMP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATACCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DMP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular CondyleBone
    BoneMandibular FossaBone
    BoneZeugopod Growth PlateBone
    BoneZeugopod PeriosteumBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb

    See DMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DMP1

    SOURCE GeneReport for Unigene cluster: Hs.652366

    UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
    Tissue specificity: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast

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    In Situ
    Assay Products:     
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    Orthologs
    for DMP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DMP1 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dmp11 , 5 dentin matrix protein 11, 5 74.7(n)1
    66.67(a)1    		   5 (50.61 cM)5
    134061  NM_016779.21  NP_058059.21 
     1042026175 
    chicken
    (Gallus gallus)    		 Aves DMP11 dentin matrix acidic phosphoprotein 44.42(n)
    32.55(a)    		   404539  NM_206993.1  NP_996876.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DMP16
    		 --
    		 15(a)
    		 1 ↔ 1
    		 5(45407237-45412225)
    zebrafish
    (Danio rerio)    		 Actinopterygii CU104742.16
    CU984580.46
    (see all 3)    		 --
    		 2(a)
    2(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(58773987-58790437)
    2(58253742-58258254)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 1(a)
    		 1 ↔ 1
    		 Group1.1(1010579-1015555)
    worm
    (Caenorhabditis elegans)    		 Secernentea ZC449.56
    Y113G7B.126
    		 Protein Y113G7B.12
    		 6(a)
    3(a)
    		 possible ortholog
    possible ortholog
    		 X(5034996-5037744)
    V(20208653-20212420)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G337406
    AT4G378206
    (see all 3)    		 uncharacterized protein
    (see all 3)    		 7(a)
    7(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 4(16186830-16189007)
    4(17785255-17787471)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 expressed protein
    		 5(a)
    13(a)
    		 possible ortholog
    possible ortholog
    		 3(29549696-29552754)
    6(21065262-21068933)


    ENSEMBL Gene Tree for DMP1 (if available)
    TreeFam Gene Tree for DMP1 (if available) 

    Paralogs
    for DMP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DMP1 gene
    DSPP2  

    DMP1 for paralogs           About GeneDecksing



    Genomic Variants
    for DMP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): DMP1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for DMP1

    Disorders / Diseases
    for DMP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DMP1 for disorders           About GeneDecksing

    OMIM gene information: 600980   
    OMIM disorders: 241520  
    UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
  • Defects in DMP1 are the cause of rickets hypophosphatemic autosomal recessive type 1 (ARHR1) [MIM:241520]. A
    • hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss,
    hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are
    bone pain, fractures and growth abnormalities

    20/23 diseases for DMP1 (see all 23):    About MalaCards
    rickets    hypophosphatemic rickets, ar    osteomalacia    hypophosphatemia
    dentinogenesis imperfecta    hereditary hypophosphatemic rickets    dentin dysplasia, type ii    oncogenic osteomalacia
    root resorption    dentin dysplasia    dental caries    aggressive periodontitis
    colon cancer    periodontitis    dermatomyositis    kidney disease
    oral cancer    osteoporosis    lung cancer    prostate cancer

    4 diseases from the University of Copenhagen DISEASES database for DMP1:
    X-linked hypophosphatemia     Hypophosphatemia     Dentinogenesis imperfecta     Rickets

    10/12 Novoseek disease relationships for DMP1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dgi-ii 95.3 3 10371253 (1), 10765957 (1)
    dentinogenesis imperfecta 92 6 9177774 (3), 8586437 (1), 8955126 (1), 9084665 (1)
    rickets hypophosphatemic 84.2 10 18162525 (1), 17635744 (1), 15187031 (1), 17341572 (1) (see all 5)
    hypophosphatemia 74.6 11 19796717 (2), 17906408 (1), 17033625 (1), 17976082 (1)
    osteomalacia 71.4 4 15001995 (1), 18257058 (1), 19669798 (1)
    collagen fibril 40.6 5 14699165 (4)
    colon cancer 0 3 16357164 (2), 15623631 (1)
    cancer lung 0 8 12929940 (4), 18559489 (2), 15623631 (1)
    metastasis 0 3 17136477 (2), 12929940 (1)
    calcification 0 3 19333978 (1), 19170059 (1)

    Human Genome Epidemiology (HuGE) Navigator: DMP1 (9 documents)

    Export disorders for DMP1 gene to outside databases

    Publications
    for DMP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DMP1 gene, integrated from 9 sources (see all 145):
    (articles sorted by number of sources associating them with DMP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21. (PubMed id 8586437)1, 2, 3, 9 Aplin H.M.... Dixon M.J. (1995)
    2. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. (PubMed id 9177774)1, 2, 3, 9 Hirst K.L....MacDougall M. (1997)
    3. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. (PubMed id 12615915)1, 2, 9 Narayanan K....George A. (2003)
    4. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. (PubMed id 17033625)1, 2, 9 Lorenz-Depiereux B.... Strom T.M. (2006)
    5. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. (PubMed id 17033621)1, 2 Feng J.Q.... White K.E. (2006)
    6. Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. (PubMed id 19007919)1, 9 Farrow E.G....White K.E. (2009)
    7. Dentin matrix protein 1 is expressed in human lung cancer. (PubMed id 12929940)1, 9 Chaplet M....Bellahcene A. (2003)
    8. Dentin matrix protein-1 isoforms promote differential cell attachment and migration. (PubMed id 18819913)1, 9 von Marschall Z. and Fisher L.W. (2008)
    9. Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression. (PubMed id 15108359)1, 9 Chen S....MacDougall M. (2004)
    10. Patterns of FGF-23, DMP1, and MEPE expression in pati ents with chronic kidney disease. (PubMed id 19679205)1, 9 Pereira R.C....Wesseling-Perry K. (2009)

    External Searches for DMP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DMP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1758 HGNC: 2932 AceView: DMP1 Ensembl:ENSG00000152592 euGenes: HUgn1758
    ECgene: DMP1 H-InvDB: DMP1

    Other Databases showing DMP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DMP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DMP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DMP1 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for DMP1 gene:
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