Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DMP1 Gene

protein-coding   GIFtS: 62
GCID: GC04P088571

Dentin Matrix Acidic Phosphoprotein 1

(Previous name: dentin matrix acidic phosphoprotein)
  See DMP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dentin Matrix Acidic Phosphoprotein 11 2
Dentin Matrix Protein 12 3
DMP-12 3
ARHP2 5
ARHR2 5
Dentin Matrix Acidic Phosphoprotein1

External Ids:    HGNC: 29321   Entrez Gene: 17582   Ensembl: ENSG000001525927   OMIM: 6009805   UniProtKB: Q133163   

Export aliases for DMP1 gene to outside databases

Previous GC identifers: GC04P088729 GC04P088873 GC04P089029 GC04P088928 GC04P084317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DMP1 Gene:
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding
ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and
dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic
domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding
domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of
osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the
extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to
cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene
structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DMP1 Gene:
DMP1 (dentin matrix acidic phosphoprotein 1) is a protein-coding gene. Diseases associated with DMP1 include osteomalacia, and hypophosphatemic rickets, autosomal recessive 1. GO annotations related to this gene include extracellular matrix binding and calcium ion binding.

UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated
osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific
genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported
into the extracellular matrix, where it regulates nucleation of hydroxyapatite

Gene Wiki entry for DMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMP1 gene promoter:
         AML1a   AP-1   p53   ATF-2   YY1   PPAR-gamma1   Chx10   c-Jun   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMP1 promoter sequence
   Search Chromatin IP Primers for DMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21

DMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088571:  view genomic region     (about GC identifiers)

Start:
88,571,454 bp from pter      End:
88,585,513 bp from pter
Size:
14,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316 (See protein sequence)
Recommended Name: Dentin matrix acidic phosphoprotein 1 precursor  
Size: 513 amino acids; 55782 Da
Subunit: Interacts with importin alpha
Secondary accessions: A1L4L3 O43265
Alternative splicing: 2 isoforms:  Q13316-1   Q13316-2   

Explore the universe of human proteins at neXtProt for DMP1: NX_Q13316

Explore proteomics data for DMP1 at MOPED

Post-translational modifications: 

  • Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is
    necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented
    by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif1
  • Glycosylation2 at Asn25, Asn285, Asn324, Asn345, Asn351, Asn413, Asn426, Asn467
  • Modification sites at PhosphoSitePlus

  • See DMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073380.1  NP_004398.1  

    ENSEMBL proteins: 
     ENSP00000340935   ENSP00000282479  
    Reactome Protein details: Q13316

    DMP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DMP1 (DMP-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DMP1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for DMP1
    OriGene Custom Protein Services for DMP1
    GenScript Custom Purified and Recombinant Proteins Services for DMP1
    Novus Biologicals DMP1 Protein
    Sino Biological Recombinant Protein for DMP1
    Sino Biological Cell Lysate for DMP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DMP1

     
    Search eBioscience for Proteins for DMP1 

    DMP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DMP1 (DMP-1)
    OriGene Antibodies for DMP1
    OriGene Custom Antibody Services for DMP1
    Novus Biologicals DMP1 Antibodies
    Abcam antibodies for DMP1
    Cloud-Clone Corp. Antibodies for DMP1
    ThermoFisher Antibodies for DMP1
    LSBio Antibodies in human, mouse, rat for DMP1

    DMP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DMP1
    R&D Systems ELISAs for DMP1 (DMP-1)
    GenScript Custom Assay Services for DMP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DMP1
    Cloud-Clone Corp. CLIAs for DMP1
    Search eBioscience for ELISAs for DMP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009889 DMP1

    Graphical View of Domain Structure for InterPro Entry Q13316

    ProtoNet protein and cluster: Q13316

    1 Blocks protein domain: IPB009889 Dentin matrix 1


    Find genes that share domains with DMP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMP1_HUMAN, Q13316
    Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated
    osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific
    genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported
    into the extracellular matrix, where it regulates nucleation of hydroxyapatite

         Genatlas biochemistry entry for DMP1:
    dentin matrix acidic phosphoprotein 1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS8509401
    GO:0005509calcium ion binding TAS8509401
    GO:0050840extracellular matrix binding IEA--
         
    Find genes that share ontologies with DMP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DMP1:
     Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dmp1):
     craniofacial  limbs/digits/tail  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with DMP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dmp1tm1.1Mis for DMP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMP1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMP1 (see all 23):
    hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-515-5p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDMP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DMP1
    Predesigned siRNA for gene silencing in human, mouse, rat DMP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DMP1

    Clone
    Products:
         
    OriGene clones in human, mouse for DMP1 (see all 10)
    OriGene ORF clones in mouse, rat for DMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DMP1 (NM_004407)
    Sino Biological Human cDNA Clone for DMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DMP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DMP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DMP1_HUMAN, Q13316: Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In
    proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast
    localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the
    release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the
    nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DMP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DMP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    2ECM proteoglycans
    ECM proteoglycans


    Find genes that share SuperPaths with DMP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DMP1
        ECM proteoglycans


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMP1
    Interactions:

        GeneGlobe Interaction Network for DMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DMP1 (Q133163 ENSP000003409354) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD44P160703, ENSP000002783854I2D: score=1 STRING: ENSP00000278385
    CFHP086033, ENSP000003563994I2D: score=1 STRING: ENSP00000356399
    CLTAENSP000002422854STRING: ENSP00000242285
    CLTBENSP000003094154STRING: ENSP00000309415
    AP1B1ENSP000003501994STRING: ENSP00000350199
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0031214biomineral tissue development IEA--

    Find genes that share ontologies with DMP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMP1

    1 HMDB Compound for DMP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for DMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rgd peptide 66.2 3 16995818 (1), 16357164 (1)
    hydroxyapatite 54.5 25 16331974 (4), 17052984 (2), 12615915 (1), 20200415 (1) (see all 8)
    miltefosine 46.5 4 19836718 (1), 19951713 (1), 20113781 (1)
    vitamin d 33.7 4 19121771 (1), 19007919 (1)
    matrigel 27.3 1 16357164 (1)
    calcium 7.54 10 12872163 (1), 18085632 (1)



    Find genes that share compounds with DMP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DMP1 gene (2 alternative transcripts): 
    NM_001079911.2  NM_004407.3  

    Unigene Cluster for DMP1:

    Dentin matrix acidic phosphoprotein 1
    Hs.652366  [show with all ESTs]
    Unigene Representative Sequence: NM_004407
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339673(uc003hqv.3) ENST00000282479(uc003hqw.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DMP1 (see all 23):
    hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-515-5p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDMP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DMP1
    Predesigned siRNA for gene silencing in human, mouse, rat DMP1
    Clone
    Products:
         
    OriGene clones in human, mouse for DMP1 (see all 10)
    OriGene ORF clones in mouse, rat for DMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DMP1 (NM_004407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for DMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMP1
      QuantiTect SYBR Green Assays in human, mouse, rat DMP1
      QuantiFast Probe-based Assays in human, mouse, rat DMP1

    Additional mRNA sequence: 

    BC130581.1 BC132865.1 U65378.1 U89012.1 

    2 DOTS entries:

    DT.95254636  DT.309049 

    8 AceView cDNA sequences:

    AI371158 BQ447431 U65378 CA428759 NM_004407 U89012 AA297032 H89203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATACCAGG
    DMP1 Expression
    About this image


    DMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
    DMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652366

    UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
    Tissue specificity: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast

        Custom PCR Arrays for DMP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for DMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMP1
    QuantiTect SYBR Green Assays in human, mouse, rat DMP1
    QuantiFast Probe-based Assays in human, mouse, rat DMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DMP1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmp11 , 5 dentin matrix protein 11, 5 72.49(n)1
    64.26(a)1
      5 (50.61 cM)5
    134061  NM_016779.21  NP_058059.21 
     1042026175 
    lizard
    (Anolis carolinensis)
    Reptilia DMP16
    dentin matrix acidic phosphoprotein 1
    26(a)
    1 ↔ 1
    5(45407237-45412225)


    ENSEMBL Gene Tree for DMP1 (if available)
    TreeFam Gene Tree for DMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DMP1 (see all 407)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0307514
    One individual with tumoral calcinosis4--see VAR_0307512 D N mis40--------
    rs1048938341,2
    Cpathogenic188385958(+) CAACTA/GTGAAG 4 M V mis10--------
    rs26154921,2
    C,F,H--88377804(+) AAACTG/ACCTCA 2 -- us2k119Minor allele frequency- A:0.14NS EA NA WA CSA 1151
    rs29041691,2
    C,F,A,H--88377896(+) CTCCTT/GGTGAT 2 -- us2k1 tfbs395Minor allele frequency- G:0.40NS EA NA PA EU CA WA 4870
    rs1465266761,2
    C--88378249(+) TGCTC-/CTCTGTT 2 -- us2k10--------
    rs1457848741,2
    --88378261(+) TTTATA/GTAGGG 2 -- us2k10--------
    rs1882919631,2
    --88378325(+) CAGAAA/TCCAAT 2 -- us2k10--------
    rs1511020661,2
    C--88378596(+) CACTCC/TAATTT 2 -- us2k10--------
    rs38386931,2
    C--88378632(-) AAAAA-/ATTGAG 2 -- us2k1 trp31Minor allele frequency- A:0.00CSA 2
    rs1407653911,2
    --88378681(+) GTTATA/GCAGAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DMP1 (88571454 - 88585513 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DMP1: --
    Human Gene Mutation Database (HGMD): DMP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for DMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600980   
    OMIM disorders: 241520  
    UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
  • Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1) [MIM:241520]: A hereditary form of
    hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss,
    hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms
    are bone pain, fractures and growth abnormalities. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 12 diseases for DMP1:    
    About MalaCards
    osteomalacia    hypophosphatemic rickets, autosomal recessive 1    hypophosphatemic rickets, ar    dentin dysplasia, type ii
    oncogenic osteomalacia    root resorption    dentinogenesis imperfecta    hypophosphatemia
    dentin dysplasia    aggressive periodontitis    x-linked hypophosphatemia    rickets

    4 diseases from the University of Copenhagen DISEASES database for DMP1:
    X-linked hypophosphatemia     Dentinogenesis imperfecta     Hypophosphatemia     Rickets

    Find genes that share disorders with DMP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DMP1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dgi-ii 95.3 3 10371253 (1), 10765957 (1)
    dentinogenesis imperfecta 92 6 9177774 (3), 8586437 (1), 8955126 (1), 9084665 (1)
    rickets hypophosphatemic 84.2 10 18162525 (1), 17635744 (1), 15187031 (1), 17341572 (1) (see all 5)
    hypophosphatemia 74.6 11 19796717 (2), 17906408 (1), 17033625 (1), 17976082 (1)
    osteomalacia 71.4 4 15001995 (1), 18257058 (1), 19669798 (1)
    collagen fibril 40.6 5 14699165 (4)
    colon cancer 0 3 16357164 (2), 15623631 (1)
    cancer lung 0 8 12929940 (4), 18559489 (2), 15623631 (1)
    metastasis 0 3 17136477 (2), 12929940 (1)
    calcification 0 3 19333978 (1), 19170059 (1)

    Genetic Association Database (GAD): DMP1
    Human Genome Epidemiology (HuGE) Navigator: DMP1 (9 documents)

    Export disorders for DMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DMP1 gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with DMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21. (PubMed id 8586437)1, 2, 3, 9 Aplin H.M.... Dixon M.J. (Genomics 1995)
    2. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. (PubMed id 9177774)1, 2, 3, 9 Hirst K.L.... McDougall M. (Genomics 1997)
    3. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. (PubMed id 12615915)1, 2, 9 Narayanan K....George A. (J. Biol. Chem. 2003)
    4. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. (PubMed id 17033625)1, 2, 9 Lorenz-Depiereux B.... Strom T.M. (Nat. Genet. 2006)
    5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    8. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. (PubMed id 17033621)1, 2 Feng J.Q.... White K.E. (Nat. Genet. 2006)
    9. Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. (PubMed id 19007919)1, 9 Farrow E.G....White K.E. (Bone 2009)
    10. Dentin matrix protein 1 is expressed in human lung cancer. (PubMed id 12929940)1, 9 Chaplet M....BellahcA"ne A. (J. Bone Miner. Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1758 HGNC: 2932 AceView: DMP1 Ensembl:ENSG00000152592 euGenes: HUgn1758
    ECgene: DMP1 H-InvDB: DMP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DMP1 gene:
    Search GeneIP for patents involving DMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for DMP1 (DMP-1)   Browse Cell Culture Products  
     ELISAs for DMP1 (DMP-1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DMP1 (DMP-1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DMP1   OriGene RNAi products in human, mouse, rat for DMP1  
     OriGene qPCR primer pairs and template standards for DMP1   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for DMP1   OriGene clones in human, mouse for DMP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DMP1   OriGene Purified Protein for DMP1  
     OriGene ORF clones in mouse, rat for DMP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DMP1   OriGene Custom Protein Services for DMP1  

     
     
     Block miRNA regulation of human, mouse, rat DMP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DMP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMP1 Predesigned siRNA for gene silencing in human, mouse, rat DMP1
     QuantiFast Probe-based Assays in human, mouse, rat DMP1 QuantiTect SYBR Green Assays in human, mouse, rat DMP1
     Custom PCR Arrays for DMP1 Search Chromatin IP Primers for DMP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMP1  GeneGlobe Interaction Network for DMP1
     Regulatory tfbs in DMP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DMP1 GenScript cDNA clones with any tag delivered in your preferred vector for DMP1
     GenScript Custom Assay Services for DMP1 GenScript Custom overexpressing Cell Line Services for DMP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DMP1
     Proteins for DMP1
     Cell Lysates for DMP1
     cDNA Clones for DMP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DMP1 antibodies
     DMP1 proteins
     Antibodies for DMP1
     See all of Abcam's Antibodies, Kits and Proteins for DMP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DMP1
     Antibodies for DMP1
     ELISAs for DMP1
     CLIAs for DMP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DMP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMP1
     SwitchGear 3'UTR luciferase reporter plasmids for DMP1
     SwitchGear Promoter luciferase reporter plasmids for DMP1
     ThermoFisher Antibodies for DMP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DMP1
     LSBio Antibodies in human, mouse, rat for DMP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DMP1
      Search eBioscience for proteins for DMP1
      Search eBioscience for elisas for DMP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DMP1 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4