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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DMP1 Gene

protein-coding   GIFtS: 59
GCID: GC04P088571

Dentin Matrix Acidic Phosphoprotein 1

(Previous name: dentin matrix acidic phosphoprotein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dentin Matrix Acidic Phosphoprotein 11 2
Dentin Matrix Protein 12 3
DMP-12 3
ARHP2 5
ARHR2 5
Dentin Matrix Acidic Phosphoprotein1

External Ids:    HGNC: 29321   Entrez Gene: 17582   Ensembl: ENSG000001525927   OMIM: 6009805   UniProtKB: Q133163   

Export aliases for DMP1 gene to outside databases

Previous GC identifers: GC04P088729 GC04P088873 GC04P089029 GC04P088928 GC04P084317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DMP1 Gene:
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding
ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and
dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic
domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding
domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of
osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the
extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to
cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene
structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DMP1 Gene: 
DMP1 (dentin matrix acidic phosphoprotein 1) is a protein-coding gene. Diseases associated with DMP1 include osteomalacia, and hypophosphatemic rickets, ar. GO annotations related to this gene include extracellular matrix binding and calcium ion binding.

UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated
osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific
genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported
into the extracellular matrix, where it regulates nucleation of hydroxyapatite

Gene Wiki entry for DMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DMP1 gene promoter:
         AML1a   AP-1   p53   ATF-2   YY1   PPAR-gamma1   Chx10   c-Jun   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21

DMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088571:  view genomic region     (about GC identifiers)

Start:
88,571,454 bp from pter      End:
88,585,513 bp from pter
Size:
14,060 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316 (See protein sequence)
Recommended Name: Dentin matrix acidic phosphoprotein 1 precursor  
Size: 513 amino acids; 55782 Da
Subunit: Interacts with importin alpha
Subcellular location: Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In
proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast
localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the
release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the
nucleus
Secondary accessions: A1L4L3 O43265
Alternative splicing: 2 isoforms:  Q13316-1   Q13316-2   

Explore the universe of human proteins at neXtProt for DMP1: NX_Q13316

Explore proteomics data for DMP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is
    necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented
    by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13316

  • DMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DMP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001073380.1  NP_004398.1  

    ENSEMBL proteins: 
     ENSP00000340935   ENSP00000282479  

    Human Recombinant Protein Products for DMP1: 
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    Sino Biological Cell Lysate for DMP1 
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    Cloud-Clone Corp. Proteins for DMP1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    DMP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009889 DMP1

    Graphical View of Domain Structure for InterPro Entry Q13316

    ProtoNet protein and cluster: Q13316

    1 Blocks protein domain: IPB009889 Dentin matrix 1


    DMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMP1_HUMAN, Q13316
    Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated
    osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific
    genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported
    into the extracellular matrix, where it regulates nucleation of hydroxyapatite

         Genatlas biochemistry entry for DMP1:
    dentin matrix acidic phosphoprotein 1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS8509401
    GO:0005509calcium ion binding TAS8509401
    GO:0050840extracellular matrix binding IEA--
         
    DMP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DMP1:
     Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dmp1):
     craniofacial  limbs/digits/tail  no phenotypic analysis  skeleton 

    DMP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dmp1tm1.1Mis for DMP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DMP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMP1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DMP1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DMP1 (see all 23):
    hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-515-5p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDMP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DMP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DMP1 (Q133163 ENSP000003409354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD44P160703, ENSP000002783854I2D: score=1 STRING: ENSP00000278385
    CFHP086033, ENSP000003563994I2D: score=1 STRING: ENSP00000356399
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization IEA--
    GO:0031214biomineral tissue development IEA--

    DMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DMP1

    1 HMDB Compound for DMP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for DMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rgd peptide 66.2 3 16995818 (1), 16357164 (1)
    hydroxyapatite 54.5 25 16331974 (4), 17052984 (2), 12615915 (1), 20200415 (1) (see all 8)
    miltefosine 46.5 4 19836718 (1), 19951713 (1), 20113781 (1)
    vitamin d 33.7 4 19121771 (1), 19007919 (1)
    matrigel 27.3 1 16357164 (1)
    calcium 7.54 10 12872163 (1), 18085632 (1)

    Search CenterWatch for drugs/clinical trials and news about DMP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DMP1 gene (2 alternative transcripts): 
    NM_001079911.2  NM_004407.3  

    Unigene Cluster for DMP1:

    Dentin matrix acidic phosphoprotein 1
    Hs.652366  [show with all ESTs]
    Unigene Representative Sequence: NM_004407
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339673(uc003hqv.3) ENST00000282479(uc003hqw.3)
    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DMP1 (see all 23):
    hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-let-7g hsa-miR-515-5p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDMP1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DMP1 (NM_004407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMP1
    Sirion Biotech Customized lentivirus for stable overexpression of DMP1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DMP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMP1

    Additional mRNA sequence: 

    BC130581.1 BC132865.1 U65378.1 U89012.1 

    2 DOTS entries:

    DT.95254636  DT.309049 

    8 AceView cDNA sequences:

    U89012 NM_004407 AI371158 BQ447431 CA428759 AA297032 U65378 H89203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DMP1 expression in normal human tissues (normalized intensities)      DMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATACCAGG
    DMP1 Expression
    About this image


    DMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Growth Plate
             skeleton/cranium/viscerocranium   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Blood (Muscoskeletal System)
             bone marrow   
     
     Spinal Cord (Nervous System)
             motor neurons   
     
     Cartilage (Muscoskeletal System)
             skeleton/cranium/viscerocranium   

    See DMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DMP1

    SOURCE GeneReport for Unigene cluster: Hs.652366

    UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
    Tissue specificity: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DMP1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmp11 , 5 dentin matrix protein 11, 5 74.7(n)1
    66.67(a)1
      5 (50.61 cM)5
    134061  NM_016779.21  NP_058059.21 
     1042026175 
    chicken
    (Gallus gallus)
    Aves DMP11 dentin matrix acidic phosphoprotein 44.42(n)
    32.55(a)
      404539  NM_206993.1  NP_996876.1 
    lizard
    (Anolis carolinensis)
    Reptilia DMP16
    Uncharacterized protein
    22(a)
    1 ↔ 1
    5(45407237-45412225)
    zebrafish
    (Danio rerio)
    Actinopterygii CU984580.46
    CU984580.46
    (see all 5)
    Uncharacterized protein
    (see all 5)
    4(a)
    4(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    2(58773987-58790437)
    2(58253742-58258254)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG150406
    --
    2(a)
    1 ↔ 1
    X(18500735-18511622)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC449.56
    F59B2.126
    (see all 5)
    Uncharacterized protein F59B2.12
    (see all 5)
    9(a)
    6(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    X(5035027-5037775)
    III(9017607-9020960)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DDR486
    DNA damage-responsive protein, expression is incre...
    12(a)
    1 → many
    XIII(608689-609981)


    ENSEMBL Gene Tree for DMP1 (if available)
    TreeFam Gene Tree for DMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/407 SNPs in DMP1 are shown (see all 407)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0307514
    One individual with tumoral calcinosis4--see VAR_0307512 D N mis40--------
    rs1048938341,2
    Cpathogenic188385958(+) CAACTA/GTGAAG 4 M V mis10--------
    rs26154921,2
    C,F,H--88377804(+) AAACTG/ACCTCA 2 -- us2k119Minor allele frequency- A:0.14NS EA NA WA CSA 1151
    rs29041691,2
    C,F,A,H--88377896(+) CTCCTT/GGTGAT 2 -- us2k1 tfbs395Minor allele frequency- G:0.40NS EA NA PA EU CA WA 4870
    rs1465266761,2
    C--88378249(+) TGCTC-/CTCTGTT 2 -- us2k10--------
    rs1457848741,2
    --88378261(+) TTTATA/GTAGGG 2 -- us2k10--------
    rs1882919631,2
    --88378325(+) CAGAAA/TCCAAT 2 -- us2k10--------
    rs1511020661,2
    C--88378596(+) CACTCC/TAATTT 2 -- us2k10--------
    rs38386931,2
    C--88378632(-) AAAAA-/ATTGAG 2 -- us2k1 trp31Minor allele frequency- A:0.00CSA 2
    rs1407653911,2
    --88378681(+) GTTATA/GCAGAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DMP1 (88571454 - 88585513 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DMP1: --

    Human Gene Mutation Database (HGMD): DMP1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600980   
    OMIM disorders: 241520  
    UniProtKB/Swiss-Prot: DMP1_HUMAN, Q13316
  • Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1) [MIM:241520]: A hereditary form of
    hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss,
    hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms
    are bone pain, fractures and growth abnormalities. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/25 diseases for DMP1 (see all 25):    About MalaCards
    osteomalacia    hypophosphatemic rickets, ar    hypophosphatemic rickets, autosomal recessive 1    dentinogenesis imperfecta
    oncogenic osteomalacia    dentin dysplasia, type ii    dentin dysplasia    root resorption
    hypophosphatemia    aggressive periodontitis    hereditary hypophosphatemic rickets    rickets
    dental caries    x-linked hypophosphatemia    dermatomyositis    oral cancer
    periodontitis    colon cancer    kidney disease    lung cancer

    4 diseases from the University of Copenhagen DISEASES database for DMP1:
    X-linked hypophosphatemia     Dentinogenesis imperfecta     Hypophosphatemia     Rickets

    DMP1 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for DMP1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dgi-ii 95.3 3 10371253 (1), 10765957 (1)
    dentinogenesis imperfecta 92 6 9177774 (3), 8586437 (1), 8955126 (1), 9084665 (1)
    rickets hypophosphatemic 84.2 10 18162525 (1), 17635744 (1), 15187031 (1), 17341572 (1) (see all 5)
    hypophosphatemia 74.6 11 19796717 (2), 17906408 (1), 17033625 (1), 17976082 (1)
    osteomalacia 71.4 4 15001995 (1), 18257058 (1), 19669798 (1)
    collagen fibril 40.6 5 14699165 (4)
    colon cancer 0 3 16357164 (2), 15623631 (1)
    cancer lung 0 8 12929940 (4), 18559489 (2), 15623631 (1)
    metastasis 0 3 17136477 (2), 12929940 (1)
    calcification 0 3 19333978 (1), 19170059 (1)

    Genetic Association Database (GAD): DMP1
    Human Genome Epidemiology (HuGE) Navigator: DMP1 (9 documents)

    Export disorders for DMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DMP1 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with DMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21. (PubMed id 8586437)1, 2, 3, 9 Aplin H.M.... Dixon M.J. (1995)
    2. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. (PubMed id 9177774)1, 2, 3, 9 Hirst K.L....MacDougall M. (1997)
    3. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. (PubMed id 12615915)1, 2, 9 Narayanan K....George A. (2003)
    4. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. (PubMed id 17033625)1, 2, 9 Lorenz-Depiereux B.... Strom T.M. (2006)
    5. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    8. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. (PubMed id 17033621)1, 2 Feng J.Q.... White K.E. (2006)
    9. Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. (PubMed id 19007919)1, 9 Farrow E.G....White K.E. (2009)
    10. Dentin matrix protein 1 is expressed in human lung cancer. (PubMed id 12929940)1, 9 Chaplet M....Bellahcene A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1758 HGNC: 2932 AceView: DMP1 Ensembl:ENSG00000152592 euGenes: HUgn1758
    ECgene: DMP1 H-InvDB: DMP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DMP1 gene:
    Search GeneIP for patents involving DMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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