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Aliases for DMKN Gene

Aliases for DMKN Gene

  • Dermokine 2 3
  • Epidermis-Specific Secreted Protein SK30/SK89 3 4
  • ZD52F10 3
  • UNQ729 3

External Ids for DMKN Gene

Previous GeneCards Identifiers for DMKN Gene

  • GC19M040680
  • GC19M035988
  • GC19M032493

Summaries for DMKN Gene

Entrez Gene Summary for DMKN Gene

  • This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DMKN Gene

DMKN (Dermokine) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DMKN Gene

  • May act as a soluble regulator of keratinocyte differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMKN Gene

Genomics for DMKN Gene

Regulatory Elements for DMKN Gene

Genomic Location for DMKN Gene

Start:
35,491,625 bp from pter
End:
35,513,661 bp from pter
Size:
22,037 bases
Orientation:
Minus strand

Genomic View for DMKN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMKN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMKN Gene

Proteins for DMKN Gene

  • Protein details for DMKN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6E0U4-DMKN_HUMAN
    Recommended name:
    Dermokine
    Protein Accession:
    Q6E0U4
    Secondary Accessions:
    • A3EZ79
    • A3EZ80
    • A3EZ81
    • A3EZ82
    • A3EZ83
    • C9J4P6
    • C9J5N8
    • C9JAL3
    • Q32W58
    • Q32W62
    • Q32W63
    • Q32W64
    • Q32W65
    • Q32W66
    • Q32W67
    • Q6E0U5
    • Q6UXC7
    • Q96EW8
    • Q9BSY6

    Protein attributes for DMKN Gene

    Size:
    476 amino acids
    Molecular mass:
    47082 Da
    Quaternary structure:
    • Homooligomer. Seems to be able to homodimerize and homotrimerize.
    SequenceCaution:
    • Sequence=AAX48757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMKN Gene

neXtProt entry for DMKN Gene

Proteomics data for DMKN Gene at MOPED

Post-translational modifications for DMKN Gene

No data available for DME Specific Peptides for DMKN Gene

Domains for DMKN Gene

Protein Domains for DMKN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DMKN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6E0U4

UniProtKB/Swiss-Prot:

DMKN_HUMAN :
  • Q6E0U4
Family:
  • Belongs to the dermokine family.
genes like me logo Genes that share domains with DMKN: view

No data available for Gene Families for DMKN Gene

Function for DMKN Gene

Molecular function for DMKN Gene

UniProtKB/Swiss-Prot Function: May act as a soluble regulator of keratinocyte differentiation.

Gene Ontology (GO) - Molecular Function for DMKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22735594
genes like me logo Genes that share ontologies with DMKN: view

Phenotypes for DMKN Gene

GenomeRNAi human phenotypes for DMKN:
genes like me logo Genes that share phenotypes with DMKN: view

Animal Model Products

miRNA for DMKN Gene

miRTarBase miRNAs that target DMKN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMKN

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DMKN Gene

Localization for DMKN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMKN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMKN Gene COMPARTMENTS Subcellular localization image for DMKN gene
Compartment Confidence
extracellular 5
cytosol 1
golgi apparatus 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DMKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DMKN: view

Pathways for DMKN Gene

SuperPathways for DMKN Gene

No Data Available

Interacting Proteins for DMKN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342012%0d%0a9606.ENSP00000324173%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000342012 Q6E0U4-DMKN_HUMAN for DMKN Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for DMKN Gene

None

No data available for Pathways by source for DMKN Gene

Transcripts for DMKN Gene

Unigene Clusters for DMKN Gene

Dermokine:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMKN

Clone Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DMKN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMKN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - - -
SP19: - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - -
SP22: - - - - - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - - - - -
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

ExUns: 17b · 17c ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c · 23d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15: - - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

Relevant External Links for DMKN Gene

GeneLoc Exon Structure for
DMKN
ECgene alternative splicing isoforms for
DMKN

Expression for DMKN Gene

mRNA expression in normal human tissues for DMKN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMKN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (22.4) and Skin - Not Sun Exposed (Suprapubic) (19.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMKN Gene

SOURCE GeneReport for Unigene cluster for DMKN Gene Hs.417795

mRNA Expression by UniProt/SwissProt for DMKN Gene

Q6E0U4-DMKN_HUMAN
Tissue specificity: Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.
genes like me logo Genes that share expressions with DMKN: view

In Situ Assay Products

Orthologs for DMKN Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMKN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMKN 35
  • 98.14 (n)
  • 96.88 (a)
cow
(Bos Taurus)
Mammalia DMKN 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMKN 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmkn 35
  • 72.29 (n)
  • 61.38 (a)
Dmkn 16
Dmkn 36
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMKN 36
  • 58 (a)
OneToOne
Species with no ortholog for DMKN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMKN Gene

ENSEMBL:
Gene Tree for DMKN (if available)
TreeFam:
Gene Tree for DMKN (if available)

Paralogs for DMKN Gene

No data available for Paralogs for DMKN Gene

Variants for DMKN Gene

Sequence variations from dbSNP and Humsavar for DMKN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs909072 - 35,500,540(+) GATCG(G/T)CTCTG reference, missense, nc-transcript-variant
rs1009004 -- 35,507,000(+) acagg(G/T)tcttc intron-variant
rs2008189 -- 35,493,751(+) TGATC(C/T)GCCTC intron-variant
rs2017100 -- 35,504,314(+) actca(C/T)gcctg intron-variant
rs2293691 -- 35,495,683(+) AGCTC(A/G)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMKN Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV Gain 17160897
nsv911628 CNV Loss 21882294
esv2718494 CNV Deletion 23290073
esv2718495 CNV Deletion 23290073
esv2718497 CNV Deletion 23290073
esv1008611 CNV Deletion 20482838
nsv138144 CNV Loss 16902084

Relevant External Links for DMKN Gene

HapMap Linkage Disequilibrium report
DMKN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMKN Gene

Disorders for DMKN Gene

No disorders were found for DMKN Gene.

No data available for UniProtKB/Swiss-Prot for DMKN Gene

Publications for DMKN Gene

  1. The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location. (PMID: 16374476) Toulza E. … Guerrin M. (J. Invest. Dermatol. 2006) 2 3 4
  2. Identification of novel keratinocyte-secreted peptides dermokine- alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. (PMID: 15234001) Matsui T. … Tsukita S. (Genomics 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Dermokine: an extensively differentially spliced gene expressed in epithelial cells. (PMID: 17380110) Naso M.F. … Amegadzie B.Y. (J. Invest. Dermatol. 2007) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for DMKN Gene

Sources for DMKN Gene

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