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Aliases for DMKN Gene

Aliases for DMKN Gene

  • Dermokine 2 3 5
  • Epidermis-Specific Secreted Protein SK30/SK89 3 4
  • ZD52F10 3
  • UNQ729 3

External Ids for DMKN Gene

Previous GeneCards Identifiers for DMKN Gene

  • GC19M040680
  • GC19M035988
  • GC19M032493
  • GC19M035765
  • GC19M035922

Summaries for DMKN Gene

Entrez Gene Summary for DMKN Gene

  • This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DMKN Gene

DMKN (Dermokine) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DMKN Gene

  • May act as a soluble regulator of keratinocyte differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMKN Gene

Genomics for DMKN Gene

Regulatory Elements for DMKN Gene

Genomic Location for DMKN Gene

Chromosome:
19
Start:
35,497,217 bp from pter
End:
35,513,668 bp from pter
Size:
16,452 bases
Orientation:
Minus strand

Genomic View for DMKN Gene

Genes around DMKN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMKN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMKN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMKN Gene

Proteins for DMKN Gene

  • Protein details for DMKN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6E0U4-DMKN_HUMAN
    Recommended name:
    Dermokine
    Protein Accession:
    Q6E0U4
    Secondary Accessions:
    • A3EZ79
    • A3EZ80
    • A3EZ81
    • A3EZ82
    • A3EZ83
    • C9J4P6
    • C9J5N8
    • C9JAL3
    • Q32W58
    • Q32W62
    • Q32W63
    • Q32W64
    • Q32W65
    • Q32W66
    • Q32W67
    • Q6E0U5
    • Q6UXC7
    • Q96EW8
    • Q9BSY6

    Protein attributes for DMKN Gene

    Size:
    476 amino acids
    Molecular mass:
    47082 Da
    Quaternary structure:
    • Homooligomer. Seems to be able to homodimerize and homotrimerize.
    SequenceCaution:
    • Sequence=AAX48757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMKN Gene

neXtProt entry for DMKN Gene

Proteomics data for DMKN Gene at MOPED

Post-translational modifications for DMKN Gene

Antibody Products

No data available for DME Specific Peptides for DMKN Gene

Domains & Families for DMKN Gene

Protein Domains for DMKN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DMKN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6E0U4

UniProtKB/Swiss-Prot:

DMKN_HUMAN :
  • Belongs to the dermokine family.
Family:
  • Belongs to the dermokine family.
genes like me logo Genes that share domains with DMKN: view

No data available for Gene Families for DMKN Gene

Function for DMKN Gene

Molecular function for DMKN Gene

UniProtKB/Swiss-Prot Function:
May act as a soluble regulator of keratinocyte differentiation.

Phenotypes for DMKN Gene

genes like me logo Genes that share phenotypes with DMKN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DMKN

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DMKN Gene

Localization for DMKN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMKN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMKN Gene COMPARTMENTS Subcellular localization image for DMKN gene
Compartment Confidence
extracellular 5
cytosol 2
golgi apparatus 2
nucleus 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DMKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DMKN: view

Pathways & Interactions for DMKN Gene

SuperPathways for DMKN Gene

No Data Available

Interacting Proteins for DMKN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342012%0d%0a9606.ENSP00000324173%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q6E0U4-DMKN_HUMAN ENSP00000342012 for DMKN Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for DMKN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DMKN Gene

Drugs & Compounds for DMKN Gene

No Compound Related Data Available

Transcripts for DMKN Gene

Unigene Clusters for DMKN Gene

Dermokine:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMKN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - - -
SP19: - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - -
SP22: - - - - - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - - - - -
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

ExUns: 17b · 17c ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c · 23d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15: - - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

Relevant External Links for DMKN Gene

GeneLoc Exon Structure for
DMKN
ECgene alternative splicing isoforms for
DMKN

Expression for DMKN Gene

mRNA expression in normal human tissues for DMKN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMKN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.4) and Skin - Not Sun Exposed (Suprapubic) (x19.0).

Protein differential expression in normal tissues from HIPED for DMKN Gene

This gene is overexpressed in Skin (51.8) and Serum (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMKN Gene



SOURCE GeneReport for Unigene cluster for DMKN Gene Hs.417795

mRNA Expression by UniProt/SwissProt for DMKN Gene

Q6E0U4-DMKN_HUMAN
Tissue specificity: Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.
genes like me logo Genes that share expression patterns with DMKN: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for DMKN Gene

Orthologs for DMKN Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMKN Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Dmkn 35
  • 72.29 (n)
  • 61.38 (a)
Dmkn 16
Dmkn 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DMKN 35
  • 98.14 (n)
  • 96.88 (a)
cow
(Bos Taurus)
Mammalia DMKN 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMKN 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMKN 36
  • 58 (a)
OneToOne
Species with no ortholog for DMKN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMKN Gene

ENSEMBL:
Gene Tree for DMKN (if available)
TreeFam:
Gene Tree for DMKN (if available)

Paralogs for DMKN Gene

No data available for Paralogs for DMKN Gene

Variants for DMKN Gene

Sequence variations from dbSNP and Humsavar for DMKN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_042720 A colorectal cancer sample
rs2293696 - 35,500,577(+) GTCCG(A/C/T)ACCCT nc-transcript-variant, reference, missense
rs909072 - 35,500,540(+) GATCG(G/T)CTCTG nc-transcript-variant, reference, missense
rs12460932 - 35,513,269(+) AGGGC(A/C/G)TCACT nc-transcript-variant, reference, missense
rs7247001 - 35,513,060(+) CACCA(C/T)TGTGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DMKN Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV Gain 17160897
nsv911628 CNV Loss 21882294
esv2718494 CNV Deletion 23290073
esv2718495 CNV Deletion 23290073
esv2718497 CNV Deletion 23290073
esv1008611 CNV Deletion 20482838
nsv138144 CNV Loss 16902084

Variation tolerance for DMKN Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.00; 93.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMKN Gene

HapMap Linkage Disequilibrium report
DMKN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMKN Gene

Disorders for DMKN Gene

Relevant External Links for DMKN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMKN

No disorders were found for DMKN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMKN Gene

Publications for DMKN Gene

  1. The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location. (PMID: 16374476) Toulza E. … Guerrin M. (J. Invest. Dermatol. 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing. (PMID: 23428944) Hasegawa M. … Takehara K. (J. Dermatol. Sci. 2013) 3
  5. Dermokine-I^ impairs ERK signaling through direct binding to GRP78. (PMID: 22735594) Higashi K. … Saito K. (FEBS Lett. 2012) 3

Products for DMKN Gene

Sources for DMKN Gene

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