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DMKN Gene

protein-coding   GIFtS: 48
GCID: GC19M035988

Dermokine

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
dermokine1 2
Epidermis-Specific Secreted Protein SK30/SK892 3
UNQ7292
ZD52F102

External Ids:    HGNC: 250631   Entrez Gene: 930992   Ensembl: ENSG000001612497   UniProtKB: Q6E0U43   
ORGUL members:         

Export aliases for DMKN gene to outside databases

Previous GC identifers: GC19M040680 GC19M032493


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DMKN Gene:
This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated
layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to
generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript
variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for DMKN Gene:
DMKN (dermokine) is a protein-coding gene.

UniProtKB/Swiss-Prot: DMKN_HUMAN, Q6E0U4
Function: May act as a soluble regulator of keratinocyte differentiation (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMKN gene promoter:
         PPAR-gamma1   C/EBPbeta   POU3F1   Brachyury   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DMKN promoter sequence
   Search Chromatin IP Primers for DMKN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMKN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

DMKN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMKN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M035988:  view genomic region     (about GC identifiers)

Start:
35,988,119 bp from pter      End:
36,004,560 bp from pter
Size:
16,442 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DMKN_HUMAN, Q6E0U4 (See protein sequence)
Recommended Name: Dermokine precursor  
Size: 476 amino acids; 47082 Da
Subunit: Homooligomer. Seems to be able to homodimerize and homotrimerize
Sequence caution: Sequence=AAX48757.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DMKN:
4F20 (3D)    
Secondary accessions: A3EZ79 A3EZ80 A3EZ81 A3EZ82 A3EZ83 C9J4P6 C9J5N8 C9JAL3 Q32W58 Q32W62
Q32W63 Q32W64 Q32W65 Q32W66 Q32W67 Q6E0U5 Q6UXC7 Q96EW8 Q9BSY6
Alternative splicing: 16 isoforms:  Q6E0U4-1   Q6E0U4-2   Q6E0U4-3   Q6E0U4-4   Q6E0U4-5   Q6E0U4-6   Q6E0U4-7   Q6E0U4-8   
Q6E0U4-9   Q6E0U4-10   Q6E0U4-11   Q6E0U4-12   Q6E0U4-13   Q6E0U4-14   Q6E0U4-15   Q6E0U4-16   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DMKN: NX_Q6E0U4

Explore proteomics data for DMKN at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Thr109
  • Modification sites at PhosphoSitePlus

  • See DMKN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001030593.1  NP_001119528.2  NP_001119529.2  NP_001119530.2  NP_001119531.1  NP_001177276.1  NP_001177277.1  NP_001177278.1  
    NP_201574.3  

    ENSEMBL proteins: 
     ENSP00000386225   ENSP00000473734   ENSP00000388378   ENSP00000474992   ENSP00000384509  
     ENSP00000470881   ENSP00000342012   ENSP00000470033   ENSP00000470425   ENSP00000412075  
     ENSP00000470510   ENSP00000392222   ENSP00000472349   ENSP00000471112   ENSP00000405503  
     ENSP00000391036   ENSP00000406864   ENSP00000474491   ENSP00000473341   ENSP00000471968  
     ENSP00000471487   ENSP00000474419   ENSP00000473526   ENSP00000471288   ENSP00000468987  
     ENSP00000472127   ENSP00000471670   ENSP00000471451   ENSP00000468840   ENSP00000469845  
     ENSP00000469824   ENSP00000473296   ENSP00000472344   ENSP00000469923   ENSP00000474995  
     ENSP00000476043   ENSP00000474123   ENSP00000473191   ENSP00000472262   ENSP00000470775  
     ENSP00000474098   ENSP00000394908   ENSP00000376042   ENSP00000403957   ENSP00000414743  
     ENSP00000388404   ENSP00000409513   ENSP00000397005   ENSP00000415277  

    DMKN Human Recombinant Protein Products:

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    antibodies-online proteins for DMKN 

     
    antibodies-online peptides for DMKN

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    antibodies-online antibodies for DMKN (6 products) 

    DMKN Assay Products:

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    antibodies-online kits for DMKN (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6E0U4

    UniProtKB/Swiss-Prot: DMKN_HUMAN, Q6E0U4
    Similarity: Belongs to the dermokine family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMKN_HUMAN, Q6E0U4
    Function: May act as a soluble regulator of keratinocyte differentiation (Potential)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with DMKN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DMKN:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Dmkn (no phenotypes)

    Find genes that share phenotypes with DMKN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dmkntm1Lex for DMKN

       genOway: Develop your customized and physiologically relevant rodent model for DMKN

    miRNA
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    miRTarBase miRNAs that target DMKN:
    hsa-mir-93-5p (MIRT027972), hsa-mir-138-5p (MIRT045834)

    Block miRNA regulation of human, mouse, rat DMKN using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DMKN:
    hsa-miR-3151 hsa-miR-486-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidDMKN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMKN

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMKN

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMKN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DMKN_HUMAN, Q6E0U4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    golgi apparatus1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with DMKN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMKN
    Interactions:

        Search GeneGlobe Interaction Network for DMKN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DMKN (Q6E0U41 ENSP000003420124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110211EBI-7943171,EBI-354921
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMKN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DMKN gene (9 alternative transcripts): 
    NM_001035516.3  NM_001126056.2  NM_001126057.2  NM_001126058.2  NM_001126059.2  NM_001190347.1  NM_001190348.1  NM_001190349.1  
    NM_033317.4  

    Unigene Cluster for DMKN:

    Dermokine
    Hs.417795  [show with all ESTs]
    Unigene Representative Sequence: BC035311
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 69):
    ENST00000472365 ENST00000408915(uc002nzi.4) ENST00000460327 ENST00000434389(uc002nzj.3)
    ENST00000488542 ENST00000402589 ENST00000462721 ENST00000339686(uc002nzo.4 uc002nzn.4 uc002nzm.4)
    ENST00000488762 ENST00000490622(uc002nzl.4 uc002nzk.4 uc002nzu.2 uc010xsw.2 uc010xsv.1)
    ENST00000436012 ENST00000467532 ENST00000414866 ENST00000480502 ENST00000469960
    ENST00000467637 ENST00000601368 ENST00000478648
    miRNA
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    Block miRNA regulation of human, mouse, rat DMKN using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DMKN:
    hsa-miR-3151 hsa-miR-486-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidDMKN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DMKN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMKN
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMKN
      QuantiTect SYBR Green Assays in human, mouse, rat DMKN
      QuantiFast Probe-based Assays in human, mouse, rat DMKN

    Additional mRNA sequence: 

    AF086315.1 AK304668.1 AK316475.1 AL832080.1 AY358412.1 AY622964.1 AY622965.1 AY789695.1 
    AY789696.1 AY789697.1 AY789698.1 AY789699.1 AY789700.1 AY789701.1 AY789702.1 AY789703.1 
    AY789704.1 AY789705.1 AY789706.1 AY789707.1 BC004493.2 BC011886.2 BC035311.1 EF158319.1 
    EF158320.1 EF158321.1 EF158322.1 EF158323.1 EF158324.1 EF158325.1 EF158326.1 NR_033746.1 

    Selected DOTS entries (see all 42):

    DT.91751126  DT.91751118  DT.95324780  DT.75155907  DT.95180791  DT.121430460  DT.100795399  DT.100027026 
    DT.121430469  DT.91751121  DT.40130997  DT.95180785  DT.102827719  DT.121430457  DT.40278777  DT.100784752 
    DT.121430435  DT.95180784  DT.100020350  DT.216664  DT.435494  DT.95086991  DT.97771032  DT.97776308 

    Selected AceView cDNA sequences (see all 193):

    AA683607 BM557961 AA385464 BU684200 AI161236 AI144221 AA854719 AI127118 
    AI217041 AA025788 AK125695 BU788071 AI288161 AA897755 AI240970 BM714383 
    AI914430 CK903380 AI148339 AI920791 BQ935633 AL832080 BI257717 BG677392 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DMKN (see all 33)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                                                    -     -     -     -     -     -     -                 -     -                 -         
    SP2:                                                                    -     -                 -     -     -                 -     -                 -         
    SP3:                                                                    -     -     -     -     -     -     -                 -     -                 -         
    SP4:                                                  -                 -     -           -           -                       -     -                 -         
    SP5:                                                  -                 -     -     -     -     -     -     -                 -     -                 -         

    ExUns: 17b · 17c ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c · 23d
    SP1:        -           -     -                 -                 -     -     -                           
    SP2:        -           -     -                 -                 -     -     -                           
    SP3:        -     -     -     -                 -                 -     -     -                           
    SP4:        -     -     -     -                                                                           
    SP5:        -           -     -                                                                           


    ECgene alternative splicing isoforms for DMKN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DMKN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTTGTTT
    DMKN Expression
    About this image


    DMKN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Brain (Nervous System)
             Striatum
    DMKN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMKN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.417795

    UniProtKB/Swiss-Prot: DMKN_HUMAN, Q6E0U4
    Tissue specificity: Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the
    epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is
    expressed in epidermis and placenta. Isoform 1 is expressed in epidermis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMKN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for DMKN gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmkn1 , 5 dermokine1, 5 72.29(n)1
    61.38(a)1
      7 (19.24 cM)5
    737121  NM_001166173.11  NP_001159645.11 
     307637565 


    ENSEMBL Gene Tree for DMKN (if available)
    TreeFam Gene Tree for DMKN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DMKN (see all 568)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0427204
    A colorectal cancer sample4--see VAR_0427202 A D mis40--------
    rs585582801,2
    C--35988846(+) TCTCT-/CT/TC 
            
    TTCTC
    3 -- int11NA 2
    rs1491634651,2
    C--35994377(+) TTTTG-/TTTTTTT 7 -- int11Minor allele frequency- TT:0.00CSA 2
    rs560565531,2
    C--35995482(+) AAAAA-/ACAAAA 7 -- int11Minor allele frequency- A:0.50CSA 2
    rs1126722481,2
    C,F--36002382(+) CTGCCG/ACCACT 12 /G syn1 int12Minor allele frequency- A:0.01CSA NA 2622
    rs2013693921,2
    --36002401(+) CACTG-/CTGCTG 14 T S fra1 int1 us2k10--------
    rs723345731,2
    C--36002419(+) TGCTG-/CCACCACT 7 -- cds1 int10--------
    rs112854511,2
    C--36002896(+) CCTCCT/-TTTTT 9 -- int1 us2k1 trp32Minor allele frequency- -:0.25NA 4
    rs1420638101,2
    C--36003538(+) CTTGAC/GCCCAG 14 A G mis10--------
    rs1856460501,2
    C--36003588(+) TTTCCA/GGGGTA 14 P syn10--------

    HapMap Linkage Disequilibrium report for DMKN (35988119 - 36004560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DMKN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718494CNV Deletion23290073
    esv2718497CNV Deletion23290073
    esv1008611CNV Deletion20482838
    esv2718495CNV Deletion23290073
    nsv138144CNV Loss16902084
    nsv911628CNV Loss21882294
    nsv833811CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DMKN gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with DMKN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location. (PubMed id 16374476)1, 2, 3 Toulza E.... Guerrin M. (J. Invest. Dermatol. 2006)
    2. Dermokine: an extensively differentially spliced gene expressed in epithelial cells. (PubMed id 17380110)1, 2 Naso M.F.... Amegadzie B.Y. (J. Invest. Dermatol. 2007)
    3. Identification of novel keratinocyte-secreted peptides dermokine- alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. (PubMed id 15234001)1, 2 Matsui T.... Tsukita S. (Genomics 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing. (PubMed id 23428944)1 Hasegawa M....Takehara K. (J. Dermatol. Sci. 2013)
    6. Dermokine expression in intraductal papillary-mucinous neoplasm and invasive pancreatic carcinoma. (PubMed id 23060565)1 Watanabe K....Otsuji E. (Anticancer Res. 2012)
    7. Dermokine-I^ impairs ERK signaling through direct binding to GRP78. (PubMed id 22735594)1 Higashi K....Saito K. (FEBS Lett. 2012)
    8. The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway. (PubMed id 21423773)1 Leclerc E.A....Jonca N. (PLoS ONE 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93099 HGNC: 25063 AceView: ZD52F10 Ensembl:ENSG00000161249 euGenes: HUgn93099
    ECgene: DMKN H-InvDB: DMKN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DMKN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DMKN gene:
    Search GeneIP for patents involving DMKN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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