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Aliases for DMC1 Gene

Aliases for DMC1 Gene

  • DNA Meiotic Recombinase 1 2 3
  • DMC1H 3 4
  • LIM15 3 4
  • DMC1 (Dosage Suppressor Of Mck1, Yeast Homolog) Meiosis-Specific Homologous Recombination 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination 3
  • Meiotic Recombination Protein DMC1/LIM15 Homolog 3
  • Disrupted Meiotic CDNA1, Yeast, Homolog Of 3
  • DJ199H16.1 3

External Ids for DMC1 Gene

Previous GeneCards Identifiers for DMC1 Gene

  • GC22M035529
  • GC22M037157
  • GC22M037239
  • GC22M038914
  • GC22M021880

Summaries for DMC1 Gene

Entrez Gene Summary for DMC1 Gene

  • This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for DMC1 Gene

DMC1 (DNA Meiotic Recombinase 1) is a Protein Coding gene. Among its related pathways are Meiosis and Meiosis. GO annotations related to this gene include DNA-dependent ATPase activity. An important paralog of this gene is RAD51B.

UniProtKB/Swiss-Prot for DMC1 Gene

  • May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Wiki entry for DMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMC1 Gene

Genomics for DMC1 Gene

Regulatory Elements for DMC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DMC1 Gene

Start:
38,518,928 bp from pter
End:
38,570,286 bp from pter
Size:
51,359 bases
Orientation:
Minus strand

Genomic View for DMC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMC1 Gene

Proteins for DMC1 Gene

  • Protein details for DMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14565-DMC1_HUMAN
    Recommended name:
    Meiotic recombination protein DMC1/LIM15 homolog
    Protein Accession:
    Q14565
    Secondary Accessions:
    • A8K9A2
    • B4DMW6
    • Q08AI1
    • Q99498
    • Q9UH11

    Protein attributes for DMC1 Gene

    Size:
    340 amino acids
    Molecular mass:
    37681 Da
    Quaternary structure:
    • Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2.

    Three dimensional structures from OCA and Proteopedia for DMC1 Gene

    Alternative splice isoforms for DMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMC1 Gene

Proteomics data for DMC1 Gene at MOPED

Post-translational modifications for DMC1 Gene

No Post-translational modifications

Other Protein References for DMC1 Gene

Antibody Products

No data available for DME Specific Peptides for DMC1 Gene

Domains for DMC1 Gene

Suggested Antigen Peptide Sequences for DMC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14565

UniProtKB/Swiss-Prot:

DMC1_HUMAN :
  • Q14565
Domain:
  • Contains 1 HhH domain.
Family:
  • Belongs to the RecA family. DMC1 subfamily.
genes like me logo Genes that share domains with DMC1: view

No data available for Gene Families for DMC1 Gene

Function for DMC1 Gene

Molecular function for DMC1 Gene

GENATLAS Biochemistry: DMC1,dosage suppressor of MCK1,S cerevisiae homolog,E Coli Rec-A like gene,forming mixed complexes with RAD51 associated with mouse meiotic chromosomes core and synaptonemal complexes,meiosis-specific homologous recombination gene
UniProtKB/Swiss-Prot Function: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Ontology (GO) - Molecular Function for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding --
GO:0005515 protein binding IPI 17541404
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DMC1: view
genes like me logo Genes that share phenotypes with DMC1: view

Animal Models for DMC1 Gene

MGI Knock Outs for DMC1:

Animal Model Products

CRISPR Products

Targeting motifs for DMC1 Gene
HOMER Transcription Factor Regulatory Elements motif DMC1
  • Consensus sequence: ACTYKNATTCGTGNTACTTC Submotif: canonical Cell Type: Testis GeoId: GSE24438

No data available for Enzyme Numbers (IUBMB) , miRNA and Transcription Factor Targeting for DMC1 Gene

Localization for DMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMC1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMC1 Gene COMPARTMENTS Subcellular localization image for DMC1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0000794 condensed nuclear chromosome IEA --
GO:0005634 nucleus IDA 22899867
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with DMC1: view

Pathways for DMC1 Gene

genes like me logo Genes that share pathways with DMC1: view

Pathways by source for DMC1 Gene

1 BioSystems pathway for DMC1 Gene
2 Reactome pathways for DMC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001556 oocyte maturation IEA --
GO:0006200 obsolete ATP catabolic process --
GO:0006259 DNA metabolic process --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with DMC1: view

Compounds for DMC1 Gene

(2) Novoseek inferred chemical compound relationships for DMC1 Gene

Compound -log(P) Hits PubMed IDs
atp 27 2
calcium 0 2
genes like me logo Genes that share compounds with DMC1: view

Transcripts for DMC1 Gene

Unigene Clusters for DMC1 Gene

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DMC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DMC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMC1 Gene

No ASD Table

Relevant External Links for DMC1 Gene

GeneLoc Exon Structure for
DMC1
ECgene alternative splicing isoforms for
DMC1

Expression for DMC1 Gene

mRNA expression in normal human tissues for DMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMC1 Gene

This gene is overexpressed in Testis (13.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DMC1 Gene

SOURCE GeneReport for Unigene cluster for DMC1 Gene Hs.339396

genes like me logo Genes that share expressions with DMC1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DMC1 Gene

Orthologs for DMC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DMC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMC1 35
  • 99.71 (n)
  • 99.71 (a)
DMC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMC1 35
  • 94.31 (n)
  • 98.82 (a)
DMC1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DMC1 35
  • 94.71 (n)
  • 99.12 (a)
DMC1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmc1 35
  • 91.96 (n)
  • 97.06 (a)
Dmc1 16
Dmc1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMC1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMC1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmc1 35
  • 91.67 (n)
  • 97.35 (a)
chicken
(Gallus gallus)
Aves DMC1 35
  • 82.54 (n)
  • 96.15 (a)
DMC1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMC1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dmc1 35
  • 79.23 (n)
  • 92.28 (a)
zebrafish
(Danio rerio)
Actinopterygii dmc1 35
  • 74.16 (n)
  • 88.76 (a)
dmc1 36
  • 88 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR101C 35
  • 57.25 (n)
  • 58.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DMC1 35
  • 58.52 (n)
  • 56.19 (a)
DMC1 36
  • 52 (a)
OneToMany
DMC1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11957g 35
  • 58.86 (n)
  • 59.49 (a)
soybean
(Glycine max)
eudicotyledons Gma.8429 35
thale cress
(Arabidopsis thaliana)
eudicotyledons DMC1 35
  • 60.29 (n)
  • 62.04 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2446 35
rice
(Oryza sativa)
Liliopsida Os12g0143800 35
  • 60.68 (n)
  • 63.47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dmc1 35
  • 59.24 (n)
  • 60.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
OneToOne
Species with no ortholog for DMC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DMC1 Gene

ENSEMBL:
Gene Tree for DMC1 (if available)
TreeFam:
Gene Tree for DMC1 (if available)

Paralogs for DMC1 Gene

Paralogs for DMC1 Gene

Selected SIMAP similar genes for DMC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMC1: view

Variants for DMC1 Gene

Sequence variations from dbSNP and Humsavar for DMC1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs962849 -- 38,565,571(+) gccta(A/T)gaggt intron-variant
rs1129426 -- 38,566,723(-) TGACA(A/T)TAAGA missense, reference, nc-transcript-variant
rs1292811 -- 38,531,881(-) ATTCC(A/G)ATAAG intron-variant
rs1980455 -- 38,529,714(+) GGCTC(A/C)CACAT intron-variant
rs2227914 - 38,538,601(-) ATCAG(A/G)TGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DMC1 Gene

Variant ID Type Subtype PubMed ID
nsv915066 CNV Loss 21882294
esv1003190 OTHER Inversion 20482838
nsv3624 CNV Loss 18451855
esv28829 CNV Loss 19812545

Relevant External Links for DMC1 Gene

HapMap Linkage Disequilibrium report
DMC1
Human Gene Mutation Database (HGMD)
DMC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMC1 Gene

Disorders for DMC1 Gene

Relevant External Links for DMC1

Genetic Association Database (GAD)
DMC1
Human Genome Epidemiology (HuGE) Navigator
DMC1
genes like me logo Genes that share disorders with DMC1: view

No data available for UniProtKB/Swiss-Prot for DMC1 Gene

Publications for DMC1 Gene

  1. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon- skipped transcript in meiosis. (PMID: 8602360) Habu T. … Morita T. (Nucleic Acids Res. 1996) 2 3 4 23
  2. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. (PMID: 15125839) Kinebuchi T. … Yokoyama S. (Mol. Cell 2004) 3 4 23
  3. Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. (PMID: 17541404) Thorslund T. … West S.C. (EMBO J. 2007) 2 3 23
  4. Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes. (PMID: 8590282) Sato S. … Tabata S. (DNA Res. 1995) 2 3 4
  5. Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. (PMID: 19004837) Volodin A.A. … Camerini-Otero R.D. (J. Biol. Chem. 2009) 3 23

Products for DMC1 Gene

Sources for DMC1 Gene

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