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DMC1 Gene(Protein Coding)

DNA Meiotic Recombinase 1

GCID:
GC22M038814
GIFtS:
61
Genes Participants
UDN Logo

Aliases for DMC1 Gene

Aliases for DMC1 Gene

  • DNA Meiotic Recombinase 1 2 3 5
  • DMC1H 3 4
  • LIM15 3 4
  • DMC1 (Dosage Suppressor Of Mck1, Yeast Homolog) Meiosis-Specific Homologous Recombination 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination 3
  • Disrupted Meiotic CDNA1, Yeast, Homolog Of 3
  • DJ199H16.1 3

External Ids for DMC1 Gene

Previous GeneCards Identifiers for DMC1 Gene

  • GC22M035529
  • GC22M037157
  • GC22M037239
  • GC22M038914
  • GC22M021880
  • GC22M038518
  • GC22M038622

Summaries for DMC1 Gene

Entrez Gene Summary for DMC1 Gene

  • This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for DMC1 Gene

DMC1 (DNA Meiotic Recombinase 1) is a Protein Coding gene. Diseases associated with DMC1 include Amebiasis. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include nucleotide binding and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for DMC1 Gene

  • May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Wiki entry for DMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMC1 Gene

Genomics for DMC1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DMC1 Gene

Enhancers for DMC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DMC1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DMC1 gene promoter:

Genomic Location for DMC1 Gene

Chromosome:
22
Start:
38,509,154 bp from pter
End:
38,570,286 bp from pter
Size:
61,133 bases
Orientation:
Minus strand

Genomic View for DMC1 Gene

Genes around DMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DMC1 Gene

Proteins for DMC1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14565-DMC1_HUMAN
    Recommended name:
    Meiotic recombination protein DMC1/LIM15 homolog
    Protein Accession:
    Q14565
    Secondary Accessions:
    • A8K9A2
    • B4DMW6
    • Q08AI1
    • Q99498
    • Q9UH11

    Protein attributes for DMC1 Gene

    Size:
    340 amino acids
    Molecular mass:
    37681 Da
    Quaternary structure:
    • Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2.

    Three dimensional structures from OCA and Proteopedia for DMC1 Gene

    Alternative splice isoforms for DMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMC1 Gene

Proteomics data for DMC1 Gene at MOPED

Protein Expression for DMC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DMC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMC1 Gene

Domains & Families for DMC1 Gene

Protein Domains for DMC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DMC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14565

UniProtKB/Swiss-Prot:

DMC1_HUMAN :
  • Contains 1 HhH domain.
  • Belongs to the RecA family. DMC1 subfamily.
Domain:
  • Contains 1 HhH domain.
Family:
  • Belongs to the RecA family. DMC1 subfamily.
genes like me logo Genes that share domains with DMC1: view

No data available for Gene Families for DMC1 Gene

Function for DMC1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DMC1 Gene

GENATLAS Biochemistry:
DMC1,dosage suppressor of MCK1,S cerevisiae homolog,E Coli Rec-A like gene,forming mixed complexes with RAD51 associated with mouse meiotic chromosomes core and synaptonemal complexes,meiosis-specific homologous recombination gene
UniProtKB/Swiss-Prot Function:
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Ontology (GO) - Molecular Function for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 four-way junction DNA binding IBA --
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity IEA,IBA --
genes like me logo Genes that share ontologies with DMC1: view

Phenotypes for DMC1 Gene

MGI mutant phenotypes for DMC1:
inferred from 3 alleles
GenomeRNAi human phenotypes for DMC1:
genes like me logo Genes that share phenotypes with DMC1: view

Animal Models for DMC1 Gene

MGI Knock Outs for DMC1:

Animal Model Products

Targeted motifs for DMC1 Gene
HOMER Transcription Factor Regulatory Elements motif DMC1
  • Consensus sequence: ACTYKNATTCGTGNTACTTC Submotif: canonical Cell Type: Testis GEO ID: GSE24438

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and Transcription Factor Targets for DMC1 Gene

Localization for DMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMC1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMC1 Gene COMPARTMENTS Subcellular localization image for DMC1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DMC1 Gene

Pathways & Interactions for DMC1 Gene

genes like me logo Genes that share pathways with DMC1: view

Pathways by source for DMC1 Gene

1 BioSystems pathway for DMC1 Gene
3 Reactome pathways for DMC1 Gene

Gene Ontology (GO) - Biological Process for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001556 oocyte maturation IEA --
GO:0007131 reciprocal meiotic recombination IEA --
GO:0010212 response to ionizing radiation IBA --
GO:0070192 chromosome organization involved in meiotic cell cycle IBA --
genes like me logo Genes that share ontologies with DMC1: view

No data available for SIGNOR curated interactions for DMC1 Gene

Drugs & Compounds for DMC1 Gene

Products:

  1. Drug

(2) Drugs for DMC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DMC1: view

Transcripts for DMC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DMC1 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMC1 Gene

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMC1 Gene

No ASD Table

Relevant External Links for DMC1 Gene

GeneLoc Exon Structure for
DMC1
ECgene alternative splicing isoforms for
DMC1

Expression for DMC1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DMC1 Gene

mRNA expression in normal human tissues for DMC1 Gene
mRNA expression by BioGPS for DMC1 GenemRNA expression by GTEx for DMC1 Gene

mRNA differential expression in normal tissues according to GTEx for DMC1 Gene

This gene is overexpressed in Testis (x13.9).

Protein differential expression in normal tissues from HIPED for DMC1 Gene

This gene is overexpressed in Ovary (28.2), Fetal ovary (26.8), and Testis (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DMC1 Gene



SOURCE GeneReport for Unigene cluster for DMC1 Gene Hs.339396

genes like me logo Genes that share expression patterns with DMC1: view

Protein tissue co-expression partners for DMC1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DMC1 Gene

Orthologs for DMC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DMC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DMC1 35
  • 94.31 (n)
  • 98.82 (a)
DMC1 36
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DMC1 35
  • 94.71 (n)
  • 99.12 (a)
DMC1 36
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dmc1 35
  • 91.96 (n)
  • 97.06 (a)
Dmc1 16
Dmc1 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia DMC1 35
  • 99.71 (n)
  • 99.71 (a)
DMC1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dmc1 35
  • 91.67 (n)
  • 97.35 (a)
oppossum
(Monodelphis domestica)
 Mammalia DMC1 36
  • 94 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DMC1 36
  • 88 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DMC1 35
  • 82.54 (n)
  • 96.15 (a)
DMC1 36
  • 95 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DMC1 36
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dmc1 35
  • 79.23 (n)
  • 92.28 (a)
zebrafish
(Danio rerio)
 Actinopterygii dmc1 35
  • 74.16 (n)
  • 88.76 (a)
dmc1 36
  • 88 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR101C 35
  • 57.25 (n)
  • 58.41 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F11957g 35
  • 58.86 (n)
  • 59.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes DMC1 35
  • 58.52 (n)
  • 56.19 (a)
DMC1 36
  • 52 (a)
 OneToMany
DMC1 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons DMC1 35
  • 60.29 (n)
  • 62.04 (a)
soybean
(Glycine max)
 eudicotyledons Gma.8429 35
barley
(Hordeum vulgare)
 Liliopsida Hv.2446 35
rice
(Oryza sativa)
 Liliopsida Os12g0143800 35
  • 60.68 (n)
  • 63.47 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes dmc1 35
  • 59.24 (n)
  • 60.06 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 77 (a)
 OneToOne
Species with no ortholog for DMC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DMC1 Gene

ENSEMBL:
Gene Tree for DMC1 (if available)
TreeFam:
Gene Tree for DMC1 (if available)

Paralogs for DMC1 Gene

(1) SIMAP similar genes for DMC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMC1: view

No data available for Paralogs for DMC1 Gene

Variants for DMC1 Gene

Sequence variations from dbSNP and Humsavar for DMC1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2227914 - 38,538,601(-) ATCAG(A/G)TGGAG reference, missense
rs58396845 - 38,549,970(+) GGTAG(C/T)CACCA intron-variant, reference, missense
rs2267392 -- 38,565,053(+) ATAGA(C/G)AAATG intron-variant
rs7289854 -- 38,519,286(+) tgaac(G/T)cctga intron-variant, utr-variant-3-prime
rs7290463 -- 38,567,182(+) CTCTT(G/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMC1 Gene

Variant ID Type Subtype PubMed ID
nsv915066 CNV Loss 21882294
esv1003190 OTHER Inversion 20482838
nsv3624 CNV Loss 18451855
esv28829 CNV Loss 19812545

Variation tolerance for DMC1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMC1 Gene

Human Gene Mutation Database (HGMD)
DMC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMC1 Gene

Disorders for DMC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DMC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amebiasis
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards
Search DMC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DMC1

Genetic Association Database (GAD)
DMC1
Human Genome Epidemiology (HuGE) Navigator
DMC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMC1
genes like me logo Genes that share disorders with DMC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DMC1 Gene

Publications for DMC1 Gene

  1. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon- skipped transcript in meiosis. (PMID: 8602360) Habu T. … Morita T. (Nucleic Acids Res. 1996) 2 3 4 23 67
  2. Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. (PMID: 17541404) Thorslund T. … West S.C. (EMBO J. 2007) 2 3 23
  3. Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. (PMID: 19004837) Volodin A.A. … Camerini-Otero R.D. (J. Biol. Chem. 2009) 3 23
  4. Biochemical analysis of the human DMC1-I37N polymorphism. (PMID: 19076215) Hikiba J. … Kurumizaka H. (FEBS J. 2009) 3 23
  5. A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments. (PMID: 18535008) Sheridan S.D. … Bishop D.K. (Nucleic Acids Res. 2008) 3 23

Products for DMC1 Gene

Sources for DMC1 Gene

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