Free for academic non-profit institutions. Other users need a Commercial license

DMC1 Gene(Protein Coding)

DNA Meiotic Recombinase 1

GCID:
GC22M040622
GIFtS:
57
Genes Participants
UDN Logo

Aliases for DMC1 Gene

Aliases for DMC1 Gene

  • DNA Meiotic Recombinase 1 2 3 5
  • DMC1H 3 4
  • LIM15 3 4
  • DMC1 (Dosage Suppressor Of Mck1, Yeast Homolog) Meiosis-Specific Homologous Recombination 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination 3
  • Meiotic Recombination Protein DMC1/LIM15 Homolog 3
  • Disrupted Meiotic CDNA1, Yeast, Homolog Of 3
  • DJ199H16.1 3

External Ids for DMC1 Gene

Previous GeneCards Identifiers for DMC1 Gene

  • GC22M035529
  • GC22M037157
  • GC22M037239
  • GC22M038914
  • GC22M021880
  • GC22M038518
  • GC22M038622
  • GC22M038814
  • GC22M039934

Summaries for DMC1 Gene

Entrez Gene Summary for DMC1 Gene

  • This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for DMC1 Gene

DMC1 (DNA Meiotic Recombinase 1) is a Protein Coding gene. Among its related pathways are Meiosis and Ovarian Infertility Genes. GO annotations related to this gene include nucleotide binding and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for DMC1 Gene

  • May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Wiki entry for DMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMC1 Gene

Genomics for DMC1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DMC1 Gene

Enhancers for DMC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F038567 1.3 Ensembl ENCODE 0.8 +0.9 899 4.7 HDGF PKNOX1 ARID4B GLI4 ZNF2 GLIS2 KLF7 ZNF263 SP3 YY2 FAM227A CBY1 ENSG00000230149 ENSG00000273076 SNORD83B ENSG00000272669 ENSG00000225450 APOBEC3D CSNK1E PRDX3P1
GH22F038550 1 Ensembl ENCODE 0.3 +20.3 20286 1.2 ESRRA MTA2 JUNB BMI1 TBX21 OSR2 SREBF1 ZNF121 ZNF366 TARDBP KDELR3 KCNJ4 DMC1 GC22P038507
GH22F038531 0.9 Ensembl ENCODE 0.3 +38.4 38427 1.5 CTCF PKNOX1 SIN3A RAD21 SMARCA4 POLR2A HMBOX1 SMC3 SPI1 KDELR3 KCNJ4 GC22P038507 DMC1
GH22F038549 0.6 ENCODE 0.3 +21.0 21016 0.2 ESRRA DPF2 SREBF1 CTBP1 GATA3 NBN RCOR1 CUX1 TCF7L2 KDELR3 KCNJ4 DMC1 GC22P038507
GH22F038512 0.8 ENCODE 0.2 +56.7 56741 1.1 ELF3 CTCF KLF1 ZNF146 SAP130 ARID4B ZIC2 RAD21 TEAD3 POLR2A JOSD1 GC22P038507 DMC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DMC1 on UCSC Golden Path with GeneCards custom track

Promoters for DMC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001532740 -14 1801 PKNOX1 GLI4 ZNF2 KLF7 ZNF263 SP3 YY2 SP5 REST TSHZ1

Transcription factor binding sites by QIAGEN in the DMC1 gene promoter:

Genomic Location for DMC1 Gene

Chromosome:
22
Start:
38,509,154 bp from pter
End:
38,570,286 bp from pter
Size:
61,133 bases
Orientation:
Minus strand

Genomic View for DMC1 Gene

Genes around DMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DMC1 Gene

Proteins for DMC1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14565-DMC1_HUMAN
    Recommended name:
    Meiotic recombination protein DMC1/LIM15 homolog
    Protein Accession:
    Q14565
    Secondary Accessions:
    • A8K9A2
    • B4DMW6
    • Q08AI1
    • Q99498
    • Q9UH11

    Protein attributes for DMC1 Gene

    Size:
    340 amino acids
    Molecular mass:
    37681 Da
    Quaternary structure:
    • Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2.

    Three dimensional structures from OCA and Proteopedia for DMC1 Gene

    Alternative splice isoforms for DMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMC1 Gene

Protein Expression for DMC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DMC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DMC1 Gene

Domains & Families for DMC1 Gene

Protein Domains for DMC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DMC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14565

UniProtKB/Swiss-Prot:

DMC1_HUMAN :
  • Contains 1 HhH domain.
  • Belongs to the RecA family. DMC1 subfamily.
Domain:
  • Contains 1 HhH domain.
Family:
  • Belongs to the RecA family. DMC1 subfamily.
genes like me logo Genes that share domains with DMC1: view

No data available for Gene Families for DMC1 Gene

Function for DMC1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DMC1 Gene

GENATLAS Biochemistry:
DMC1,dosage suppressor of MCK1,S cerevisiae homolog,E Coli Rec-A like gene,forming mixed complexes with RAD51 associated with mouse meiotic chromosomes core and synaptonemal complexes,meiosis-specific homologous recombination gene
UniProtKB/Swiss-Prot Function:
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Ontology (GO) - Molecular Function for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000150 recombinase activity IBA --
GO:0000166 nucleotide binding IEA --
GO:0000400 four-way junction DNA binding IBA --
GO:0003677 DNA binding IEA,TAS 8602360
GO:0003690 double-stranded DNA binding IBA --
genes like me logo Genes that share ontologies with DMC1: view
genes like me logo Genes that share phenotypes with DMC1: view

Animal Models for DMC1 Gene

MGI Knock Outs for DMC1:

Animal Model Products

Targeted motifs for DMC1 Gene
HOMER Transcription Factor Regulatory Elements motif DMC1
  • Consensus sequence: ACTYKNATTCGTGNTACTTC Submotif: canonical Cell Type: Testis GEO ID: GSE24438

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and Transcription Factor Targets for DMC1 Gene

Localization for DMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMC1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMC1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0000794 condensed nuclear chromosome IEA,TAS --
GO:0005634 nucleus IDA 22899867
GO:0005654 nucleoplasm IBA --
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with DMC1: view

Pathways & Interactions for DMC1 Gene

genes like me logo Genes that share pathways with DMC1: view

Pathways by source for DMC1 Gene

1 BioSystems pathway for DMC1 Gene
3 Reactome pathways for DMC1 Gene

Gene Ontology (GO) - Biological Process for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000730 DNA recombinase assembly IBA --
GO:0001541 ovarian follicle development IEA --
GO:0001556 oocyte maturation IEA --
GO:0006259 DNA metabolic process IEA --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with DMC1: view

No data available for SIGNOR curated interactions for DMC1 Gene

Drugs & Compounds for DMC1 Gene

Products:

  1. Drug

(2) Drugs for DMC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DMC1: view

Transcripts for DMC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DMC1 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMC1 Gene

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMC1 Gene

No ASD Table

Relevant External Links for DMC1 Gene

GeneLoc Exon Structure for
DMC1
ECgene alternative splicing isoforms for
DMC1

Expression for DMC1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DMC1 Gene

mRNA expression in normal human tissues for DMC1 Gene
mRNA expression by BioGPS for DMC1 GenemRNA expression by GTEx for DMC1 Gene

mRNA differential expression in normal tissues according to GTEx for DMC1 Gene

This gene is overexpressed in Testis (x13.9).

Protein differential expression in normal tissues from HIPED for DMC1 Gene

This gene is overexpressed in Ovary (28.2), Fetal ovary (26.8), and Testis (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DMC1 Gene



Protein tissue co-expression partners for DMC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DMC1 Gene:

DMC1

SOURCE GeneReport for Unigene cluster for DMC1 Gene:

Hs.339396
genes like me logo Genes that share expression patterns with DMC1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DMC1 Gene

Orthologs for DMC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DMC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DMC1 34 35
  • 99.71 (n)
dog
(Canis familiaris)
 Mammalia DMC1 34 35
  • 94.71 (n)
cow
(Bos Taurus)
 Mammalia DMC1 34 35
  • 94.31 (n)
oppossum
(Monodelphis domestica)
 Mammalia DMC1 35
  • 94 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dmc1 34 16 35
  • 91.96 (n)
rat
(Rattus norvegicus)
 Mammalia Dmc1 34
  • 91.67 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia DMC1 35
  • 88 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DMC1 34 35
  • 82.54 (n)
lizard
(Anolis carolinensis)
 Reptilia DMC1 35
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dmc1 34
  • 79.23 (n)
zebrafish
(Danio rerio)
 Actinopterygii dmc1 34 35
  • 74.16 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F11957g 34
  • 58.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes DMC1 34 35 37
  • 58.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR101C 34
  • 57.25 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons DMC1 34
  • 60.29 (n)
soybean
(Glycine max)
 eudicotyledons Gma.8429 34
rice
(Oryza sativa)
 Liliopsida Os12g0143800 34
  • 60.68 (n)
barley
(Hordeum vulgare)
 Liliopsida Hv.2446 34
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 77 (a)
 OneToOne
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes dmc1 34
  • 59.24 (n)
Species where no ortholog for DMC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DMC1 Gene

ENSEMBL:
Gene Tree for DMC1 (if available)
TreeFam:
Gene Tree for DMC1 (if available)

Paralogs for DMC1 Gene

(1) SIMAP similar genes for DMC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMC1: view

No data available for Paralogs for DMC1 Gene

Variants for DMC1 Gene

Sequence variations from dbSNP and Humsavar for DMC1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10427947 -- 38,540,546(+) AACCT(C/T)ATTTC intron-variant
rs10439917 -- 38,532,556(+) acctc(A/G)tgatc intron-variant
rs10650131 -- 38,551,292(+) AATAT(-/AA)GTTAC intron-variant
rs11089888 -- 38,522,518(-) AGTGG(A/C)TGATC intron-variant
rs11089890 -- 38,556,216(-) aaaaa(G/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DMC1 Gene

Variant ID Type Subtype PubMed ID
nsv3624 CNV deletion 18451855
nsv1136678 CNV deletion 24896259
nsv1131658 CNV deletion 24896259
esv3647737 CNV loss 21293372
esv28829 CNV loss 19812545
esv1003190 OTHER inversion 20482838

Variation tolerance for DMC1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DMC1 Gene

Human Gene Mutation Database (HGMD)
DMC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMC1 Gene

Disorders for DMC1 Gene

Relevant External Links for DMC1

Genetic Association Database (GAD)
DMC1
Human Genome Epidemiology (HuGE) Navigator
DMC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DMC1

No disorders were found for DMC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMC1 Gene

Publications for DMC1 Gene

  1. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon- skipped transcript in meiosis. (PMID: 8602360) Habu T. … Morita T. (Nucleic Acids Res. 1996) 2 3 4 22 64
  2. Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. (PMID: 17541404) Thorslund T. … West S.C. (EMBO J. 2007) 2 3 22 64
  3. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. (PMID: 15125839) Kinebuchi T. … Yokoyama S. (Mol. Cell 2004) 3 4 22 64
  4. Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes. (PMID: 8590282) Sato S. … Tabata S. (DNA Res. 1995) 2 3 4 64
  5. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou M.A. … Kyriacou K. (Breast Cancer Res. Treat. 2010) 3 46 64

Products for DMC1 Gene

Sources for DMC1 Gene

Content
Loading form....