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DMBX1 Gene

protein-coding   GIFtS: 47
GCID: GC01P046974

Diencephalon/Mesencephalon Homeobox 1

(Previous name: orthodenticle homolog 3 (Drosophila))
(Previous symbol: OTX3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diencephalon/Mesencephalon Homeobox 11 2     PAXB2 3
OTX31 2 3     Orthodenticle Homolog 3 (Drosophila)1
Orthodenticle Homolog 32 3     Diencephalon/Mesencephalon Homeobox Protein 12
Paired-Like Homeobox Protein DMBX12 3     Homeoprotein MBX2
MBX2 3     

External Ids:    HGNC: 190261   Entrez Gene: 1273432   Ensembl: ENSG000001975877   OMIM: 6074105   UniProtKB: Q8NFW53   

Export aliases for DMBX1 gene to outside databases

Previous GC identifers: GC01P046343 GC01P046684 GC01P045088


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DMBX1 Gene:
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded
protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript
variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DMBX1 Gene:
DMBX1 (diencephalon/mesencephalon homeobox 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSC.

UniProtKB/Swiss-Prot: DMBX1_HUMAN, Q8NFW5
Function: Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a
heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMBX1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   IRF-2   E2F   E2F-1   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMBX1 promoter sequence
   Search Chromatin IP Primers for DMBX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMBX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34.1

DMBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMBX1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046974:  view genomic region     (about GC identifiers)

Start:
46,972,668 bp from pter      End:
46,979,898 bp from pter
Size:
7,231 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DMBX1_HUMAN, Q8NFW5 (See protein sequence)
Recommended Name: Diencephalon/mesencephalon homeobox protein 1  
Size: 382 amino acids; 41198 Da
Subunit: Homodimer or heterodimer. Forms heterodimers with OTX2 (By similarity)
Sequence caution: Sequence=BAC00920.1; Type=Erroneous initiation;
Secondary accessions: A6NNN2 Q8NFW6 Q8NHD9
Alternative splicing: 2 isoforms:  Q8NFW5-1   Q8NFW5-2   

Explore the universe of human proteins at neXtProt for DMBX1: NX_Q8NFW5

Explore proteomics data for DMBX1 at MOPED


See DMBX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_671725.1  NP_757379.1  

ENSEMBL proteins: 
 ENSP00000353132   ENSP00000361024  

DMBX1 Human Recombinant Protein Products:

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Novus Biologicals DMBX1 Lysate
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Cloud-Clone Corp. Proteins for DMBX1

 
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antibodies-online proteins for DMBX1 (5 products) 

 
antibodies-online peptides for DMBX1

DMBX1 Antibody Products:

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antibodies-online antibodies for DMBX1 (12 products) 

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Cloud-Clone Corp. ELISAs for DMBX1
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antibodies-online kits for DMBX1 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

4 InterPro protein domains:
 IPR003654 OAR_dom
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q8NFW5

ProtoNet protein and cluster: Q8NFW5

1 Blocks protein domain: IPB003654 Paired-like homeodomain protein

UniProtKB/Swiss-Prot: DMBX1_HUMAN, Q8NFW5
Similarity: Belongs to the paired homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with DMBX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DMBX1_HUMAN, Q8NFW5
Function: Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a
heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity)

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ISS--
GO:0003700sequence-specific DNA binding transcription factor activity ISS--
GO:0042803protein homodimerization activity IEA--
GO:0043565sequence-specific DNA binding ISS--
GO:0046982protein heterodimerization activity IEA--
     
Find genes that share ontologies with DMBX1           About GenesLikeMe


Phenotypes:
     7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Dmbx1):
 adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging 
 nervous system  reproductive system 

Find genes that share phenotypes with DMBX1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Dmbx1tm1Bhr for DMBX1

   genOway: Develop your customized and physiologically relevant rodent model for DMBX1

miRNA
Products:
    
miRTarBase miRNAs that target DMBX1:
hsa-mir-335-5p (MIRT017349)

Block miRNA regulation of human, mouse, rat DMBX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DMBX1 (see all 20):
hsa-miR-3678-3p hsa-miR-1321 hsa-miR-765 hsa-miR-331-3p hsa-miR-488 hsa-miR-486-3p hsa-miR-342-3p hsa-miR-3692
SwitchGear 3'UTR luciferase reporter plasmidDMBX1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for DMBX1
Predesigned siRNA for gene silencing in human, mouse, rat DMBX1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for DMBX1

Clone
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OriGene clones in human, mouse for DMBX1 (see all 9)
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GenScript: all cDNA clones in your preferred vector (see all 2): DMBX1 (NM_147192)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMBX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMBX1

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMBX1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DMBX1_HUMAN, Q8NFW5: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005667transcription factor complex IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DMBX1 About    
See pathways by source

SuperPathContained pathways About
1Neural Crest Differentiation
Neural Crest Differentiation


1 BioSystems Pathway for DMBX1
    Neural Crest Differentiation


    Pathway & Disease-focused RT2 Profiler PCR Array including DMBX1: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for DMBX1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for DMBX1 (Q8NFW53 ENSP000003531324) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
OTX2P322433, ENSP000003438194I2D: score=2 STRING: ENSP00000343819
CHEK2ENSP000003720234STRING: ENSP00000372023
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007417central nervous system development ISS--
GO:0007420brain development ISS--

Find genes that share ontologies with DMBX1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DMBX1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DMBX1 gene (2 alternative transcripts): 
NM_147192.2  NM_172225.1  

Unigene Cluster for DMBX1:

Diencephalon/mesencephalon homeobox 1
Hs.375623
Unigene Representative Sequence: NM_147192
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360032(uc001cpw.3) ENST00000371956(uc001cpx.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DMBX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DMBX1 (see all 20):
hsa-miR-3678-3p hsa-miR-1321 hsa-miR-765 hsa-miR-331-3p hsa-miR-488 hsa-miR-486-3p hsa-miR-342-3p hsa-miR-3692
SwitchGear 3'UTR luciferase reporter plasmidDMBX1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DMBX1
Predesigned siRNA for gene silencing in human, mouse, rat DMBX1
Clone
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OriGene clones in human, mouse for DMBX1 (see all 9)
OriGene ORF clones in mouse, rat for DMBX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DMBX1 (NM_147192)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DMBX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DMBX1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for DMBX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DMBX1
  QuantiTect SYBR Green Assays in human, mouse, rat DMBX1
  QuantiFast Probe-based Assays in human, mouse, rat DMBX1

Additional mRNA sequence: 

AB037699.1 AF398527.1 AF398528.1 AY726596.1 

1 DOTS entry:

DT.100017320 

5 AceView cDNA sequences:

AF398528 AF398527 NM_172225 NM_147192 AB037699 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DMBX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DMBX1 Expression
About this image


DMBX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 15 entries
         Thalamus
         Substantia Nigra   
 
 Neural Tube (Nervous System)    fully expand to see all 6 entries
         Metencephalon
         brain/midbrain/lateral wall   
 
 Spinal Cord (Nervous System)
DMBX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DMBX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.375623
    Pathway & Disease-focused RT2 Profiler PCR Array including DMBX1: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for DMBX1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMBX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DMBX1 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dmbx11 , 5 diencephalon/mesencephalon homeobox 11, 5 87.54(n)1
93.68(a)1
  4 (53.07 cM)5
1404771  NM_130865.31  NP_570935.31 
 1159145445 
chicken
(Gallus gallus)
Aves DMBX11 diencephalon/mesencephalon homeobox 1 75.63(n)
80.39(a)
  395271  XM_001234035.2  XP_001234036.1 
lizard
(Anolis carolinensis)
Reptilia DMBX16
diencephalon/mesencephalon homeobox 1
81(a)
1 ↔ 1
4(112340672-112368289)
African clawed frog
(Xenopus laevis)
Amphibia Xl.321872 Xenopus laevis transcribed sequence with moderate similarity more 81.33(n)    BJ093923.1 
zebrafish
(Danio rerio)
Actinopterygii dmbx12 diencephalon/mesencephalon-expressed brain homeobox more 81.19(n)   142987  AF398525.1 
worm
(Caenorhabditis elegans)
Secernentea ceh-366
Protein CEH-36 (ceh-36) mRNA, complete cds
26(a)
1 ↔ 1
X(14183449-14185597) WBGene00000457


ENSEMBL Gene Tree for DMBX1 (if available)
TreeFam Gene Tree for DMBX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DMBX1 gene
GSC2  PITX12  OTX22  UNCX2  VSX12  HESX12  PITX22  VSX22  
PROP12  PITX32  GSC22  CRX2  OTX12  MIXL12  
2 SIMAP similar genes for DMBX1 using alignment to 1 protein entry:     DMBX1_HUMAN:
HLX    POU6F1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DMBX1 (see all 264)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1880885691,2
--46970716(+) ACCACA/TATGAG 2 -- us2k10--------
rs559291431,2
C--46971165(+) ACTATC/TGCAAG 2 -- us2k10--------
rs118034251,2
H--46971342(+) gggtgC/Tagcac 2 -- us2k10--------
rs617830651,2
F--46971369(+) TATACG/ATATGT 2 -- us2k11Minor allele frequency- A:0.00NA 2
rs1927316761,2
--46971431(+) AATAAA/TAAAAA 2 -- us2k10--------
rs715726131,2
C--46971458(+) TACTT-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50NA 2
rs1154731811,2
C,F--46971482(+) AATAAG/ACCTGC 2 -- us2k11Minor allele frequency- A:0.04WA 118
rs751209151,2
C,F--46971555(+) CTCTGA/GGCCTC 2 -- us2k11Minor allele frequency- G:0.15WA 118
rs1117968731,2
C--46971729(+) TCTTTTTTTTA/-
        
TTTTT
2 -- cds11Minor allele frequency- -:0.50CSA 2
rs613437551,2
C--46971734(+) TTTTTATTTTT/-
        
GGAGA
2 -- cds11Minor allele frequency- -:0.00NA 2

HapMap Linkage Disequilibrium report for DMBX1 (46972668 - 46979898 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DMBX1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DMBX1
DNA2.0 Custom Variant and Variant Library Synthesis for DMBX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607410    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for DMBX1:
Microphthalmia

Find genes that share disorders with DMBX1           About GenesLikeMe


Export disorders for DMBX1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DMBX1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DMBX1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. The homeobox gene mbx is involved in eye and tectum development. (PubMed id 12142024)1, 2 Kawahara A.... Dawid I.B. (Dev. Biol. 2002)
  3. Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. (PubMed id 12055180)1, 2 Zhang Y.... Seino S. (J. Biol. Chem. 2002)
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
  5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
  6. Mutational analysis of the human MBX gene in four Korean families demonstrating microphthalmia with congenital cataract. (PubMed id 17990594)1 Miyamoto T....Sengoku K. (Turk. J. Pediatr. 2007)
  7. Functional analysis of transcriptional repressor Otx3/Dmbx1. (PubMed id 15890343)1 Kimura K....Seino S. (FEBS Lett. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 127343 HGNC: 19026 AceView: DMBX1 Ensembl:ENSG00000197587 euGenes: HUgn127343
ECgene: DMBX1 H-InvDB: DMBX1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DMBX1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DMBX1 gene:
Search GeneIP for patents involving DMBX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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