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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DMAP1 Gene

protein-coding   GIFtS: 53
GCID: GC01P044680

DNA Methyltransferase 1 Associated Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DNA Methyltransferase 1 Associated Protein 11 2     MEAF22
DNMAP12 3     SWC42
DNMT1-Associated Protein 12 3     DNA Methyltransferase 1-Associated Protein 12
DNMTAP12     DNMT1 Associated Protein 12
EAF22     KIAA14253

External Ids:    HGNC: 182911   Entrez Gene: 559292   Ensembl: ENSG000001780287   OMIM: 6050775   UniProtKB: Q9NPF53   

Export aliases for DMAP1 gene to outside databases

Previous GC identifers: GC01U990334 GC01P043680 GC01P044108 GC01P044092 GC01P044348 GC01P044451 GC01P042792


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DMAP1 Gene:
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of
transcription. The encoded protein can independently repress transcription and is targeted to replication foci
throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase,
histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally
inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome
acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101
and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants
encoding the same protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for DMAP1 Gene: 
DMAP1 (DNA methyltransferase 1 associated protein 1) is a protein-coding gene. Diseases associated with DMAP1 include eaf, and pharyngitis. GO annotations related to this gene include RNA polymerase II repressing transcription factor binding and chromatin binding.

UniProtKB/Swiss-Prot: DMAP1_HUMAN, Q9NPF5
Function: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism
for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also
repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated
repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase
(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of
nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote
interaction of the modified histones with other proteins which positively regulate transcription. This complex
may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene
mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA
repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the
nuclear localization of URI1 and increases its transcriptional corepressor activity

Gene Wiki entry for DMAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DMAP1 gene promoter:
         N-Myc   CREB   AML1a   Pax-5   deltaCREB   ATF   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DMAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DMAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34

DMAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMAP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044680:  view genomic region     (about GC identifiers)

Start:
44,679,125 bp from pter      End:
44,686,353 bp from pter
Size:
7,229 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DMAP1_HUMAN, Q9NPF5 (See protein sequence)
Recommended Name: DNA methyltransferase 1-associated protein 1  
Size: 467 amino acids; 52993 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related
complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin,
ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it
interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1
interacts with ING1, a component of the mSin3A transcription repressor complex, although this interaction is not
required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor
TSG101. Interacts with the pro-apoptotic protein DAXX. Interacts with URI1
Subcellular location: Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1
Sequence caution: Sequence=BAA92663.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for DMAP1:
3HM5 (3D)        4IEJ (3D)    
Secondary accessions: A8K001 D3DPY8 Q0JSM4 Q5TG41 Q7Z3H7 Q9H0S8 Q9P2C2

Explore the universe of human proteins at neXtProt for DMAP1: NX_Q9NPF5

Explore proteomics data for DMAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPF5

  • DMAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DMAP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001029195.1  NP_001029196.1  NP_061973.1  

    ENSEMBL proteins: 
     ENSP00000354697   ENSP00000409200   ENSP00000401099   ENSP00000400269   ENSP00000402494  
     ENSP00000312697   ENSP00000361363   ENSP00000361364  

    Human Recombinant Protein Products for DMAP1: 
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    OriGene Protein Over-expression Lysate for DMAP1
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    Novus Biologicals DMAP1 Protein
    Novus Biologicals DMAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DMAP1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10888872
    GO:0005657replication fork IEA--
    GO:0005737cytoplasm IDA15367675
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    DMAP1 for ontologies           About GeneDecksing



    DMAP1 Antibody Products: 
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    ThermoFisher Antibody for DMAP1
    LSBio Antibodies in human, mouse, rat for DMAP1 

    Assay Products for DMAP1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DMAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DMAP1 
    Cloud-Clone Corp. CLIAs for DMAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR027109 Swc4/Dmap1
     IPR008468 DMAP1

    Graphical View of Domain Structure for InterPro Entry Q9NPF5

    ProtoNet protein and cluster: Q9NPF5

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: DMAP1_HUMAN, Q9NPF5
    Similarity: Contains 1 SANT domain


    DMAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMAP1_HUMAN, Q9NPF5
    Function: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism
    for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also
    repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated
    repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase
    (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of
    nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote
    interaction of the modified histones with other proteins which positively regulate transcription. This complex
    may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene
    mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA
    repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the
    nuclear localization of URI1 and increases its transcriptional corepressor activity

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001103RNA polymerase II repressing transcription factor binding IDA15367675
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI15367675
         
    DMAP1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for DMAP1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Downregulation of NF-kappaB pa  Increased G2M DNA content 
     Increased circadian rhythm amp 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dmap1):
     cellular  mortality/aging  no phenotypic analysis  reproductive system 

    DMAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dmap1tm1(KOMP)Vlcg for DMAP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DMAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DMAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMAP1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DMAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DMAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/820 Interacting proteins for DMAP1 (Q9NPF52, 3 ENSP000003126974) via UniProtKB, MINT, STRING, and/or I2D (see all 820)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000221413
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000349960
    TSG101Q998162, 3, ENSP000002519684MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000251968
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000362649
    HSPA5P110212, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15367675
    GO:0006281DNA repair IEA--
    GO:0006306DNA methylation TAS10888872
    GO:0006338chromatin remodeling IEA--
    GO:0006351transcription, DNA-dependent IEA--

    DMAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DMAP1

    Search CenterWatch for drugs/clinical trials and news about DMAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DMAP1 gene (3 alternative transcripts): 
    NM_001034023.1  NM_001034024.1  NM_019100.4  

    Unigene Cluster for DMAP1:

    DNA methyltransferase 1 associated protein 1
    Hs.8008  [show with all ESTs]
    Unigene Representative Sequence: NM_019100
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361745(uc001clq.1) ENST00000446292(uc010okt.1) ENST00000440641
    ENST00000436069 ENST00000437511 ENST00000475794(uc010okq.1 uc010okr.1 uc010oks.1)
    ENST00000471829 ENST00000487922 ENST00000315913(uc001clr.1 uc010oku.1)
    ENST00000372289(uc001cls.1) ENST00000463950 ENST00000372290 ENST00000488433
    ENST00000483741 ENST00000494092
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate DMAP1:
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    OriGene ORF clones in mouse, rat for DMAP1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DMAP1

    Additional mRNA sequence: 

    AB037846.1 AF265228.1 AK021605.1 AK289366.1 AK293598.1 AK298793.1 AK300217.1 AK300372.1 
    AK300442.1 AL136657.1 AL137200.1 BC002855.2 BC008053.2 

    24/27 DOTS entries (see all 27):

    DT.100819674  DT.100721825  DT.75179550  DT.97768073  DT.97848192  DT.95370332  DT.121437270  DT.100819682 
    DT.100030295  DT.121437346  DT.91758097  DT.121437332  DT.95370337  DT.121437323  DT.100819671  DT.91758088 
    DT.95370335  DT.100715922  DT.121437324  DT.100030296  DT.100819669  DT.121437335  DT.121437395  DT.91758090 

    24/347 AceView cDNA sequences (see all 347):

    BU507486 BM544676 F09405 AA378606 BU932104 BC008053 BU607344 BF929891 
    BX325320 CD518344 BU185944 CB152303 BI966244 CA488401 F08876 Z40907 
    CB123593 BX338742 BU738989 AI168113 AI337406 BC002855 CA843384 CF131098 

    GeneLoc Exon Structure

    5/23 Alternative Splicing Database (ASD) splice patterns (SP) for DMAP1 (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^
    SP1:                    -     -     -     -                             -     -     -                                   -     -     -     -     -     -         
    SP2:                    -     -     -                                   -     -     -                                   -     -     -     -     -     -         
    SP3:                                                                    -     -     -                                   -     -     -     -     -     -         
    SP4:                    -     -     -                                   -           -                                   -     -     -     -     -     -         
    SP5:                                                                                                                                                            

    ExUns: 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for DMAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DMAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCACTGGC
    DMAP1 Expression
    About this image


    See DMAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DMAP1

    SOURCE GeneReport for Unigene cluster: Hs.8008
        SABiosciences Custom PCR Arrays for DMAP1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DMAP1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmap11 , 5 DNA methyltransferase 1-associated protein 11, 5 89.44(n)1
    98.07(a)1
      4 (53.46 cM)5
    662331  NM_023178.21  NP_075667.11 
     1176746815 
    chicken
    (Gallus gallus)
    Aves DMAP11 DNA methyltransferase 1 associated protein 1 75.4(n)
    86.46(a)
      424578  XM_422417.3  XP_422417.3 
    lizard
    (Anolis carolinensis)
    Reptilia DMAP16
    Uncharacterized protein
    88(a)
    1 ↔ 1
    4(109235843-109274098)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.32442 Xenopus laevis transcribed sequence with weak similarity more 74.98(n)    CD329679.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555932 similar to DNA methyltransferase 1-associated protein more 73.35(n)   393225  BC048054.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111323
    DMAP11
    CG11132-PA1 48(a)3
    56.65(n)1
    53.03(a)1
      57A93
    373391  NM_137659.31  NP_611503.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.173
    ekl-41
    Protein EKL-41 40(a)3
    49.01(n)1
    42.54(a)1
      I(14477547-14484526)3
    1733101  NM_001129058.11  NP_001122530.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWC4(YGR002C)4 Component of the Swr1p complex that incorporates Htz1p more   --   7(499906-498476) 852885  NP_011516.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G472101 DNA methyltransferase 1-associated protein 1 46.47(n)
    37.06(a)
      819334  NM_180139.3  NP_850470.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05408001 hypothetical protein 43.34(n)
    34.99(a)
      4339468  NM_001062718.1  NP_001056183.1 


    ENSEMBL Gene Tree for DMAP1 (if available)
    TreeFam Gene Tree for DMAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/236 SNPs in DMAP1 are shown (see all 236)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345107201,2
    C--44677166(+) TTTAA-/ACCAAT 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs798861521,2
    --44677166(+) CTGTTA/TAACCA 3 -- us2k10--------
    rs1438576641,2
    --44677296(+) ATCCAC/TTGCCA 3 -- us2k10--------
    rs1483806251,2
    --44677299(+) CATTGC/TCACTG 3 -- us2k10--------
    rs790370241,2
    C,F--44677358(+) ACTGCC/TCTCTA 3 -- us2k12Minor allele frequency- T:0.05NA 122
    rs1415663941,2
    --44677660(+) CATTTC/TCTTCC 3 -- us2k10--------
    rs1508847481,2
    --44677661(+) ATTTCC/TTTCCT 3 -- us2k10--------
    rs1836602011,2
    --44677665(+) CCTTCC/TTAGCT 3 -- us2k10--------
    rs1887062221,2
    --44677799(+) AGTCTA/CGAATA 3 -- us2k10--------
    rs8033701,2
    C,F,A--44677803(-) GCACTG/ATTCTA 3 -- us2k113Minor allele frequency- A:0.12NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for DMAP1 (44679125 - 44686353 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DMAP1: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for DMAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605077    OMIM disorders: --

    8 diseases for DMAP1:    About MalaCards
    eaf    pharyngitis    seminoma    germ cell tumors
    transitional cell carcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma    gastric cancer


    DMAP1 for disorders           About GeneDecksing


    Export disorders for DMAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DMAP1 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with DMAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PubMed id 10888872)1, 2, 3, 9 Rountree M.R.... Baylin S.B. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. (PubMed id 14665632)1, 2, 9 Xin H.... Qin J. (2004)
    4. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (2003)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (2004)
    9. Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. (PubMed id 14978102)1, 2 Muromoto R.... Matsuda T. (2004)
    10. Subcellular localization of RPB5-mediating protein and its putative functional partner. (PubMed id 15367675)1, 2 Delgermaa L....Murakami S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55929 HGNC: 18291 AceView: DMAP1 Ensembl:ENSG00000178028 euGenes: HUgn55929
    ECgene: DMAP1 H-InvDB: DMAP1

    (According to HUGE)
    About This Section
    HUGE: KIAA1425

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DMAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DMAP1 gene:
    Search GeneIP for patents involving DMAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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