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Aliases for DMAP1 Gene

Aliases for DMAP1 Gene

  • DNA Methyltransferase 1 Associated Protein 1 2 3
  • DNMT1-Associated Protein 1 3 4
  • DNMAP1 3 4
  • DNA Methyltransferase 1-Associated Protein 1 3
  • DNMT1 Associated Protein 1 3
  • KIAA1425 4
  • DNMTAP1 3
  • MEAF2 3
  • EAF2 3
  • SWC4 3

External Ids for DMAP1 Gene

Previous GeneCards Identifiers for DMAP1 Gene

  • GC01U990334
  • GC01P043680
  • GC01P044108
  • GC01P044092
  • GC01P044348
  • GC01P044451
  • GC01P044680
  • GC01P042792

Summaries for DMAP1 Gene

Entrez Gene Summary for DMAP1 Gene

  • This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DMAP1 Gene

DMAP1 (DNA Methyltransferase 1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include chromatin binding and RNA polymerase II repressing transcription factor binding.

UniProtKB/Swiss-Prot for DMAP1 Gene

  • Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Gene Wiki entry for DMAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMAP1 Gene

Genomics for DMAP1 Gene

Regulatory Elements for DMAP1 Gene

Genomic Location for DMAP1 Gene

Start:
44,213,453 bp from pter
End:
44,220,681 bp from pter
Size:
7,229 bases
Orientation:
Plus strand

Genomic View for DMAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DMAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMAP1 Gene

Proteins for DMAP1 Gene

  • Protein details for DMAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPF5-DMAP1_HUMAN
    Recommended name:
    DNA methyltransferase 1-associated protein 1
    Protein Accession:
    Q9NPF5
    Secondary Accessions:
    • A8K001
    • D3DPY8
    • Q0JSM4
    • Q5TG41
    • Q7Z3H7
    • Q9H0S8
    • Q9P2C2

    Protein attributes for DMAP1 Gene

    Size:
    467 amino acids
    Molecular mass:
    52993 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSin3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with the pro-apoptotic protein DAXX. Interacts with URI1.
    SequenceCaution:
    • Sequence=BAA92663.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMAP1 Gene

neXtProt entry for DMAP1 Gene

Proteomics data for DMAP1 Gene at MOPED

Post-translational modifications for DMAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DMAP1 Gene

No data available for DME Specific Peptides for DMAP1 Gene

Domains for DMAP1 Gene

Protein Domains for DMAP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DMAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPF5

UniProtKB/Swiss-Prot:

DMAP1_HUMAN :
  • Q9NPF5
Domain:
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with DMAP1: view

No data available for Gene Families for DMAP1 Gene

Function for DMAP1 Gene

Molecular function for DMAP1 Gene

UniProtKB/Swiss-Prot Function: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Gene Ontology (GO) - Molecular Function for DMAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IDA 15367675
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 15367675
genes like me logo Genes that share ontologies with DMAP1: view
genes like me logo Genes that share phenotypes with DMAP1: view

miRNA for DMAP1 Gene

miRTarBase miRNAs that target DMAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DMAP1 Gene

Localization for DMAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMAP1 Gene

Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DMAP1 Gene COMPARTMENTS Subcellular localization image for DMAP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DMAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10888872
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IEA --
GO:0005737 cytoplasm IDA 15367675
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with DMAP1: view

Pathways for DMAP1 Gene

genes like me logo Genes that share pathways with DMAP1: view

Pathways by source for DMAP1 Gene

Gene Ontology (GO) - Biological Process for DMAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15367675
GO:0006281 DNA repair IEA --
GO:0006306 DNA methylation TAS 10888872
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling IEA --
genes like me logo Genes that share ontologies with DMAP1: view

Transcripts for DMAP1 Gene

Unigene Clusters for DMAP1 Gene

DNA methyltransferase 1 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DMAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - -
SP13: - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - -
SP18: - - - - - - - - -
SP19: - - -
SP20: - - - -
SP21:
SP22: - - - - -
SP23:

ExUns: 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for DMAP1 Gene

GeneLoc Exon Structure for
DMAP1
ECgene alternative splicing isoforms for
DMAP1

Expression for DMAP1 Gene

mRNA expression in normal human tissues for DMAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DMAP1 Gene

SOURCE GeneReport for Unigene cluster for DMAP1 Gene Hs.8008

genes like me logo Genes that share expressions with DMAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DMAP1 Gene

Orthologs for DMAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DMAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMAP1 35
  • 99.57 (n)
  • 100 (a)
DMAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
OneToMany
DMAP1 35
  • 92.47 (n)
  • 98.66 (a)
DMAP1 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DMAP1 35
  • 91.5 (n)
  • 99.55 (a)
DMAP1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dmap1 35
  • 89.56 (n)
  • 97.99 (a)
Dmap1 16
Dmap1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMAP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DMAP1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dmap1 35
  • 89.19 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves DMAP1 35
  • 76.9 (n)
  • 88.94 (a)
DMAP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DMAP1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3244 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dmap1 35
  • 73.81 (n)
  • 84.2 (a)
Str.296 35
zebrafish
(Danio rerio)
Actinopterygii dmap1 35
  • 71.78 (n)
  • 79.68 (a)
dmap1 36
  • 80 (a)
OneToOne
zgc55593 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007387 35
  • 56.94 (n)
  • 54.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta DMAP1 35
  • 56.94 (n)
  • 53.81 (a)
DMAP1 36
  • 49 (a)
OneToOne
CG11132 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea ekl-4 35
  • 49.37 (n)
  • 43.15 (a)
ekl-4 36
  • 33 (a)
OneToOne
Y105E8A.17 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWC4 36
  • 20 (a)
OneToOne
SWC4 38
SWC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47210 35
  • 46.15 (n)
  • 36.56 (a)
rice
(Oryza sativa)
Liliopsida Os05g0540800 35
  • 43.9 (n)
  • 35.98 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1946 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for DMAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DMAP1 Gene

ENSEMBL:
Gene Tree for DMAP1 (if available)
TreeFam:
Gene Tree for DMAP1 (if available)

Paralogs for DMAP1 Gene

No data available for Paralogs for DMAP1 Gene

Variants for DMAP1 Gene

Sequence variations from dbSNP and Humsavar for DMAP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15001 -- 44,220,203(-) CTGGG(C/G)CTGAT missense, reference
rs709266 -- 44,215,523(-) CTTAC(A/G)TGTTT intron-variant
rs709267 -- 44,215,811(-) GTGCT(C/G)TGCTG intron-variant
rs709268 -- 44,216,412(-) tctct(A/T)aaaaa intron-variant
rs803369 -- 44,213,884(+) CGTTG(A/G)CTAGG intron-variant, upstream-variant-2KB

Relevant External Links for DMAP1 Gene

HapMap Linkage Disequilibrium report
DMAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DMAP1 Gene

Disorders for DMAP1 Gene

No disorders were found for DMAP1 Gene.

No data available for UniProtKB/Swiss-Prot for DMAP1 Gene

Publications for DMAP1 Gene

  1. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PMID: 10888872) Rountree M.R. … Baylin S.B. (Nat. Genet. 2000) 2 3 4 23
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  4. Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. (PMID: 14665632) Xin H. … Qin J. (J. Biol. Chem. 2004) 3 4 23
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for DMAP1 Gene

  • Addgene plasmids for DMAP1

Sources for DMAP1 Gene

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