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DMAP1 Gene

protein-coding   GIFtS: 56
GCID: GC01P044680

DNA Methyltransferase 1 Associated Protein 1

  See DMAP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA Methyltransferase 1 Associated Protein 11 2     MEAF22
DNMAP12 3     SWC42
DNMT1-Associated Protein 12 3     DNA Methyltransferase 1-Associated Protein 12
DNMTAP12     DNMT1 Associated Protein 12
EAF22     KIAA14253

External Ids:    HGNC: 182911   Entrez Gene: 559292   Ensembl: ENSG000001780287   OMIM: 6050775   UniProtKB: Q9NPF53   

Export aliases for DMAP1 gene to outside databases

Previous GC identifers: GC01U990334 GC01P043680 GC01P044108 GC01P044092 GC01P044348 GC01P044451 GC01P042792


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DMAP1 Gene:
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of
transcription. The encoded protein can independently repress transcription and is targeted to replication foci
throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase,
histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally
inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome
acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101
and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants
encoding the same protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for DMAP1 Gene:
DMAP1 (DNA methyltransferase 1 associated protein 1) is a protein-coding gene. Diseases associated with DMAP1 include male germ cell tumor. GO annotations related to this gene include RNA polymerase II repressing transcription factor binding and chromatin binding.

UniProtKB/Swiss-Prot: DMAP1_HUMAN, Q9NPF5
Function: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism
for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also
repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated
repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase
(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of
nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote
interaction of the modified histones with other proteins which positively regulate transcription. This complex
may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene
mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA
repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the
nuclear localization of URI1 and increases its transcriptional corepressor activity

Gene Wiki entry for DMAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DMAP1 gene promoter:
         N-Myc   CREB   AML1a   Pax-5   deltaCREB   ATF   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDMAP1 promoter sequence
   Search Chromatin IP Primers for DMAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DMAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34

DMAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMAP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044680:  view genomic region     (about GC identifiers)

Start:
44,679,125 bp from pter      End:
44,686,353 bp from pter
Size:
7,229 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DMAP1_HUMAN, Q9NPF5 (See protein sequence)
Recommended Name: DNA methyltransferase 1-associated protein 1  
Size: 467 amino acids; 52993 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related
complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin,
ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it
interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1
interacts with ING1, a component of the mSin3A transcription repressor complex, although this interaction is not
required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor
TSG101. Interacts with the pro-apoptotic protein DAXX. Interacts with URI1
Sequence caution: Sequence=BAA92663.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for DMAP1:
3HM5 (3D)        4IEJ (3D)    
Secondary accessions: A8K001 D3DPY8 Q0JSM4 Q5TG41 Q7Z3H7 Q9H0S8 Q9P2C2

Explore the universe of human proteins at neXtProt for DMAP1: NX_Q9NPF5

Explore proteomics data for DMAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DMAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001029195.1  NP_001029196.1  NP_061973.1  

    ENSEMBL proteins: 
     ENSP00000354697   ENSP00000409200   ENSP00000401099   ENSP00000400269   ENSP00000402494  
     ENSP00000312697   ENSP00000361363   ENSP00000361364  
    Reactome Protein details: Q9NPF5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR027109 Swc4/Dmap1
     IPR008468 DMAP1

    Graphical View of Domain Structure for InterPro Entry Q9NPF5

    ProtoNet protein and cluster: Q9NPF5

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: DMAP1_HUMAN, Q9NPF5
    Similarity: Contains 1 SANT domain


    Find genes that share domains with DMAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DMAP1_HUMAN, Q9NPF5
    Function: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism
    for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also
    repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated
    repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase
    (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of
    nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote
    interaction of the modified histones with other proteins which positively regulate transcription. This complex
    may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene
    mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA
    repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the
    nuclear localization of URI1 and increases its transcriptional corepressor activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001103RNA polymerase II repressing transcription factor binding IDA15367675
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI15367675
         
    Find genes that share ontologies with DMAP1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for DMAP1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Downregulation of NF-kappaB pa  Increased G2M DNA content 
     Increased circadian rhythm amp 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dmap1):
     cellular  mortality/aging  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with DMAP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dmap1tm1(KOMP)Vlcg for DMAP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DMAP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DMAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DMAP1

    miRNA
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    miRTarBase miRNAs that target DMAP1:
    hsa-mir-16-5p (MIRT031691), hsa-mir-331-3p (MIRT043441)

    Block miRNA regulation of human, mouse, rat DMAP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DMAP1:
    hsa-miR-138-2*
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DMAP1_HUMAN, Q9NPF5: Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10888872
    GO:0005654nucleoplasm TAS--
    GO:0005657replication fork IEA--
    GO:0005737cytoplasm IDA15367675
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    Find genes that share ontologies with DMAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DMAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with DMAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DMAP1
        HATs acetylate histones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DMAP1
    Interactions:

        GeneGlobe Interaction Network for DMAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DMAP1 (Q9NPF52, 3 ENSP000003126974) via UniProtKB, MINT, STRING, and/or I2D (see all 869)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000221413
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000349960
    TSG101Q998162, 3, ENSP000002519684MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000251968
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000362649
    HSPA5P110212, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15367675
    GO:0006281DNA repair IEA--
    GO:0006306DNA methylation TAS10888872
    GO:0006325chromatin organization TAS--
    GO:0006338chromatin remodeling IEA--

    Find genes that share ontologies with DMAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DMAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DMAP1 gene (3 alternative transcripts): 
    NM_001034023.1  NM_001034024.1  NM_019100.4  

    Unigene Cluster for DMAP1:

    DNA methyltransferase 1 associated protein 1
    Hs.8008  [show with all ESTs]
    Unigene Representative Sequence: NM_019100
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361745(uc001clq.1) ENST00000446292(uc010okt.1) ENST00000440641
    ENST00000436069 ENST00000437511 ENST00000475794(uc010okq.1 uc010okr.1 uc010oks.1)
    ENST00000471829 ENST00000487922 ENST00000315913(uc001clr.1 uc010oku.1)
    ENST00000372289(uc001cls.1) ENST00000463950 ENST00000372290 ENST00000488433
    ENST00000483741 ENST00000494092
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      QuantiFast Probe-based Assays in human, mouse, rat DMAP1

    Additional mRNA sequence: 

    AB037846.1 AF265228.1 AK021605.1 AK289366.1 AK293598.1 AK298793.1 AK300217.1 AK300372.1 
    AK300442.1 AL136657.1 AL137200.1 BC002855.2 BC008053.2 

    Selected DOTS entries (see all 27):

    DT.100819674  DT.100721825  DT.75179550  DT.97768073  DT.97848192  DT.95370332  DT.121437270  DT.100819682 
    DT.100030295  DT.121437346  DT.91758097  DT.121437332  DT.95370337  DT.121437323  DT.100819671  DT.91758088 
    DT.95370335  DT.100715922  DT.121437324  DT.100030296  DT.100819669  DT.121437335  DT.121437395  DT.91758090 

    Selected AceView cDNA sequences (see all 347):

    BX325320 BU508165 BM712064 CA488401 F09405 AW937027 CD518344 AW166747 
    AL137200 F08877 BI831615 BM021276 BI908825 BI966244 CA840948 CB152303 
    BF836870 BU185944 BX508663 CB156183 BQ011777 BI769792 BU607344 CA843384 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DMAP1 (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^
    SP1:                    -     -     -     -                             -     -     -                                   -     -     -     -     -     -         
    SP2:                    -     -     -                                   -     -     -                                   -     -     -     -     -     -         
    SP3:                                                                    -     -     -                                   -     -     -     -     -     -         
    SP4:                    -     -     -                                   -           -                                   -     -     -     -     -     -         
    SP5:                                                                                                                                                            

    ExUns: 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for DMAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DMAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCACTGGC
    DMAP1 Expression
    About this image

    DMAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DMAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8008
        Custom PCR Arrays for DMAP1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DMAP1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dmap11 , 5 DNA methyltransferase 1-associated protein 11, 5 89.56(n)1
    97.99(a)1
      4 (53.46 cM)5
    662331  NM_023178.21  NP_075667.11 
     1176746815 
    chicken
    (Gallus gallus)
    Aves DMAP11 DNA methyltransferase 1 associated protein 1 76.9(n)
    88.94(a)
      424578  XM_422417.4  XP_422417.3 
    lizard
    (Anolis carolinensis)
    Reptilia DMAP16
    DNA methyltransferase 1 associated protein 1
    86(a)
    1 ↔ 1
    4(109235843-109274098)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.32442 Xenopus laevis transcribed sequence with weak similarity more 74.98(n)    CD329679.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555932 similar to DNA methyltransferase 1-associated protein more 73.35(n)   393225  BC048054.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111323
    DMAP11
    DMAP11 48(a)3
    56.94(n)1
    53.81(a)1
      57A93
    373391  NM_137659.41  NP_611503.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.173
    ekl-41
    ekl-41 40(a)3
    49.37(n)1
    43.15(a)1
      I(14477547-14484526)3
    1733101  NM_001129058.21  NP_001122530.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWC4(YGR002C)4 Component of the Swr1p complex that incorporates Htz1p more   --   7(499906-498476) 852885  NP_011516.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G472101 AT2G47210 46.15(n)
    36.56(a)
      819334  NM_180139.3  NP_850470.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05408001 Os05g0540800 43.9(n)
    35.98(a)
      4339468  NM_001062718.1  NP_001056183.1 


    ENSEMBL Gene Tree for DMAP1 (if available)
    TreeFam Gene Tree for DMAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DMAP1 (see all 236)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345107201,2
    C--44677166(+) TTTAA-/ACCAAT 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs798861521,2
    --44677166(+) CTGTTA/TAACCA 3 -- us2k10--------
    rs1438576641,2
    --44677296(+) ATCCAC/TTGCCA 3 -- us2k10--------
    rs1483806251,2
    --44677299(+) CATTGC/TCACTG 3 -- us2k10--------
    rs790370241,2
    C,F--44677358(+) ACTGCC/TCTCTA 3 -- us2k12Minor allele frequency- T:0.05NA 122
    rs1415663941,2
    --44677660(+) CATTTC/TCTTCC 3 -- us2k10--------
    rs1508847481,2
    --44677661(+) ATTTCC/TTTCCT 3 -- us2k10--------
    rs1836602011,2
    --44677665(+) CCTTCC/TTAGCT 3 -- us2k10--------
    rs1887062221,2
    --44677799(+) AGTCTA/CGAATA 3 -- us2k10--------
    rs8033701,2
    C,F,A--44677803(-) GCACTG/ATTCTA 3 -- us2k113Minor allele frequency- A:0.12NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for DMAP1 (44679125 - 44686353 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DMAP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DMAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for DMAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605077    OMIM disorders: --

    1 disease for DMAP1:    
    About MalaCards
    male germ cell tumor


    Find genes that share disorders with DMAP1           About GenesLikeMe


    Export disorders for DMAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DMAP1 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with DMAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PubMed id 10888872)1, 2, 3, 9 Rountree M.R.... Baylin S.B. (Nat. Genet. 2000)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. (PubMed id 14665632)1, 2, 9 Xin H.... Qin J. (J. Biol. Chem. 2004)
    4. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (Curr. Opin. Genet. Dev. 2004)
    9. Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. (PubMed id 14978102)1, 2 Muromoto R.... Matsuda T. (J. Immunol. 2004)
    10. Subcellular localization of RPB5-mediating protein and its putative functional partner. (PubMed id 15367675)1, 2 Delgermaa L....Murakami S. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55929 HGNC: 18291 AceView: DMAP1 Ensembl:ENSG00000178028 euGenes: HUgn55929
    ECgene: DMAP1 H-InvDB: DMAP1

    (According to HUGE)
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    HUGE: KIAA1425

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DMAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DMAP1 gene:
    Search GeneIP for patents involving DMAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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