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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLX6 Gene

protein-coding   GIFtS: 51
GCID: GC07P096634

distal-less homeobox 6

(Previous name: distal-less homeo box 6 )
 Explore 8 diseases affiliated with
DLX6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DLX6    

Aliases
for DLX6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Distal-Less Homeobox 61 2
Distal-Less Homeo Box 61 2
Homeobox Protein DLX-62

External Ids:    HGNC: 29191   Entrez Gene: 17502   Ensembl: ENSG000000063777   OMIM: 6000305   UniProtKB: P561793   

Export aliases for DLX6 gene to outside databases

Previous GC identifers: GC07P095170 GC07P096233 GC07P096247 GC07P096279 GC07P096473 GC07P091222


Summaries
for DLX6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DLX6:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene.
This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial
development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of
chromosome 7. (provided by RefSeq, Jul 2008)

Gene Wiki entry for DLX6


Genomic Views
for DLX6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLX6 gene promoter:
         E2F-3a   E2F-4   AP-1   ATF-2   E2F-2   PPAR-gamma1   E2F-1   E2F   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

DLX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P096634:  view genomic region     (about GC identifiers)

Start:
 96,634,860 bp from pter      End:
 96,640,352 bp from pter
Size:
 5,493 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 95,957,784-95,962,846     

Proteins
for DLX6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DLX6_HUMAN, P56179 (See protein sequence)
Recommended Name: Homeobox protein DLX-6  
Size: 175 amino acids; 19708 Da
Subcellular location: Nucleus (Potential)
Developmental stage: First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic vesicles
and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing forebrain in
primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos, expressed in the brain and
bones, and also in all skeletal structures of midgestation embryos after the first cartilage formation, and expression
progressively declines in both brain and skeleton in day 15 embryos
Secondary accessions: A4D1I2 B3KSQ0 Q3ZAR6 Q9UPL2
Alternative splicing: 2 isoforms:  P56179-1   P56179-2   

Explore the universe of human proteins at neXtProt for DLX6: NX_P56179

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56179

    • DLX6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005213.3  
    ENSEMBL proteins: 
     ENSP00000428480   ENSP00000451635   ENSP00000007660  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: DLX6
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    Novus Biologicals DLX6 Proteins
    Novus Biologicals DLX6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DLX6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    DLX6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DLX6

    Protein Domains /
    Families
    for DLX6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DLX6 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P56179

    ProtoNet protein and cluster: P56179

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX6_HUMAN, P56179
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for DLX6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for DLX6:
    Drosophila distal less homolog Dlx6,homeo domain encoding gene,expressed in brain and skeleton

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX6
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX6 (see all 36):
    hsa-miR-596 hsa-miR-4272 hsa-miR-550a* hsa-miR-548l hsa-miR-4275 hsa-miR-10b* hsa-miR-508-5p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: DLX6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX6 (see all 4)
    OriGene shRNA RFP: DLX6
    OriGene siRNA: DLX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DLX6

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLX6 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: DLX6 (NM_005222)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DLX6
    LifeMap BioReagents: cell line associated with DLX6: PureStem MEL2, NCr-fac Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX6

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--


    DLX6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DLX6:
     Decreased Hepatitis C virus re 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dlx6):
     craniofacial  digestive/alimentary  embryogenesis  growth/size  hearing/vestibular/ear 
     integument  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton  vision/eye 

    DLX6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DLX6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLX6

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS7907794
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development TAS7907794
    GO:0030326embryonic limb morphogenesis ----
    GO:0030855epithelial cell differentiation ----


    DLX6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DLX6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLX6
    Search CenterWatch for drugs/clinical trials and news about DLX6 

    Transcripts
    for DLX6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DLX6 gene: 
    NM_005222.3  

    Unigene Cluster for DLX6:

    Distal-less homeobox 6
    Hs.249196  [show with all ESTs]
    Unigene Representative Sequence: NM_005222
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518156(uc022ahu.1) ENST00000493273 ENST00000555308 ENST00000007660


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX6
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX6 (see all 36):
    hsa-miR-596 hsa-miR-4272 hsa-miR-550a* hsa-miR-548l hsa-miR-4275 hsa-miR-10b* hsa-miR-508-5p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: DLX6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX6 (see all 4)
    OriGene shRNA RFP: DLX6
    OriGene siRNA: DLX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLX6 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLX6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DLX6 (NM_005222)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLX6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DLX6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX6

    Additional cDNA sequence: 

    AK094086.1 BC069363.1 BC103688.1 BC103689.1 BC103690.1 BC109381.1 

    4 DOTS entries:

    DT.452117  DT.101961765  DT.421941  DT.100801418 

    24/26 AceView cDNA sequences (see all 26):

    F11981 F13543 BX281177 F09629 AI859314 BC069363 AK094086 BX327009 
    BU616500 AA300186 CF994779 AA077087 BX115138 BX353127 AA040413 T65197 
    AA040402 AA040332 BX374960 AA300187 AW514987 T65128 AI961486 BX353128 

    GeneLoc Exon Structure


    Expression
    for DLX6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DLX6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneCaudal Endochondral BonesHypertrophic ChondrocytesBone, Cartilage
    BoneCaudal Endochondral BonesPrehypertrophic ChondrocytesBone, Cartilage
    BoneEndochondral Facial BonesHypertrophic ChondrocytesBone, Cartilage
    BoneEndochondral Facial BonesPrehypertrophic ChondrocytesBone, Cartilage
    BoneRostral Endochondral Facial BonesHypertrophic ChondrocytesBone, Cartilage
    BoneRostral Endochondral Facial BonesPrehypertrophic ChondrocytesBone, Cartilage
    CartilageSynchondrosesPrechondrocytesBone, Cartilage
    CartilageTemporomandibular JointHypertrophic ChondrocytesBone, Cartilage
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 1Osteochondro Mesenchymal CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See DLX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLX6

    SOURCE GeneReport for Unigene cluster: Hs.249196
        SABiosciences Expression via Pathway-Focused PCR Array including DLX6: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX6

    Orthologs
    for DLX6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DLX6 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DLX61 distal-less homeobox 6 86.27(n)
    92.51(a)    		   772070  NM_001080890.1  NP_001074359.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DLX66
    		 --
    		 96(a)
    		 1 ↔ 1
    		 6(23237885-23243005)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.2622 Xenopus mRNA for homeodomain homologous to Drosophila more 81.28(n)    D10259.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dlx6a2 distal-less homeobox gene 6a 74.25(n)   30586  NM_131323.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dll6
    		 Distal-less
    		 21(a)
    		 possible ortholog
    		 2R(20702353-20722686)


    ENSEMBL Gene Tree for DLX6 (if available)
    TreeFam Gene Tree for DLX6 (if available) 

    Paralogs
    for DLX6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLX6 gene
    DLX22  BARX12  BSX2  DLX52  BARHL22  BARHL12  DLX42  BARX22  
    DLX12  MSX22  MSX12  DLX32  
    18/22 SIMAP similar genes for DLX6 using alignment to 3 protein entries:     DLX6_HUMAN (see all proteins) (see all similar genes):
    MNX1    DLX1    HMX2    NKX2-5    PITX2    HOXB1
    MEOX1    DLX4    DLX5    BARX1    MSX1    DLX3
    CDX1    DLX2    NKX1-1    HOXA4    NANOG    NKX2-6

    DLX6 for paralogs           About GeneDecksing



    Genomic Variants
    for DLX6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 NCBI SNPs in DLX6 are shown (see all 97)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1454168351,2
    		--96633535(+) CGGAGA/GGAGAA 2 -- us2k1 int10--------
    rs1886075591,2
    		--96633644(+) AATCCC/TCTTGC 2 -- int1 us2k10--------
    rs1810628561,2
    		--96633725(+) TAAATA/GCGGCA 2 -- int1 us2k10--------
    rs1851005041,2
    		--96633767(+) GAGGCA/GACACT 2 -- us2k1 int10--------
    rs1894512541,2
    		--96633886(+) AATTTA/GAACAA 2 -- int1 us2k10--------
    rs1488167601,2
    		--96634107(+) GCCAAA/GCCACT 2 -- us2k1 int10--------
    rs1174861611,2
    		C,F,--96634136(+) CATATA/GTTTGA 2 -- int1 us2k11Minor allele frequency- G:0.02NA 120
    rs752885811,2
    		--96634148(+) AGCATT/CACAGT 2 -- us2k1 int11Minor allele frequency- C:0.01NA 120
    rs1822477681,2
    		--96634169(+) TTCAAC/TAGGAA 2 -- us2k1 int10--------
    rs802924221,2
    		C--96634171(+) CAATAG/TGAAAA 2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for DLX6 (96634860 - 96640352 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DLX6: --
    Human Gene Mutation Database (HGMD): DLX6

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLX6
    DNA2.0 Custom Variant and Variant Library Synthesis for DLX6

    Disorders / Diseases
    for DLX6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DLX6 for disorders           About GeneDecksing

    OMIM gene information: 600030    OMIM disorders: --

    8 diseases for DLX6:    About MalaCards
    hearing loss    acute lymphoblastic leukemia    lymphoblastic leukemia    hypospadias
    pharyngitis    leukemia    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DLX6:
    Rett syndrome

    1 Novoseek disease relationship for DLX6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rett syndrome 57.6 1 17701895 (1)

    Human Genome Epidemiology (HuGE) Navigator: DLX6 (3 documents)

    Export disorders for DLX6 gene to outside databases

    Publications
    for DLX6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLX6 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with DLX6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 3, 9 Simeone A....Boncinelli E. (1994)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. (PubMed id 17701895)1, 9 Schule B....Francke U. (2007)
    6. Expression analysis and mutation detection of DLX5 an d DLX6 in autism. (PubMed id 19195802)1, 9 Nakashima N....Momoi M.Y. (2010)
    7. No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. (PubMed id 12707945)1, 9 Nabi R....Huq A.H. (2003)
    8. Rapp-Hodgkin syndrome and SHFM1 patients: delineating the p63-Dlx5/Dlx6 pathway. (PubMed id 22342398)1 Vera-Carbonell A....Lopez-Exposito I. (2012)
    9. Mutually exclusive expression of DLX2 and DLX5/6 is a ssociated with the metastatic potential of the human breast cancer cell line MD A-MB-231. (PubMed id 21108812)1 Morini M....Barbieri O. (2010)
    10. Genome-wide profiling of p63 DNA-binding sites identi fies an element that regulates gene expression during limb development in the 7 q21 SHFM1 locus. (PubMed id 20808887)1 Kouwenhoven E.N....Zhou H. (2010)

    External Searches for DLX6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DLX6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1750 HGNC: 2919 AceView: DLX6 Ensembl:ENSG00000006377 euGenes: HUgn1750
    ECgene: DLX6 H-InvDB: DLX6

    Other Databases showing DLX6 gene

    (According to HUGE)
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    Specialized Databases showing DLX6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLX6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DLX6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DLX6 gene:
    Search GeneIP for patents involving DLX6

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