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Aliases for DLX6 Gene

Aliases for DLX6 Gene

  • Distal-Less Homeobox 6 2 3 5
  • Distal-Less Homeo Box 6 2

External Ids for DLX6 Gene

Previous GeneCards Identifiers for DLX6 Gene

  • GC07P095170
  • GC07P096233
  • GC07P096247
  • GC07P096279
  • GC07P096473
  • GC07P096634
  • GC07P091222

Summaries for DLX6 Gene

Entrez Gene Summary for DLX6 Gene

  • This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLX6 Gene

DLX6 (Distal-Less Homeobox 6) is a Protein Coding gene. Diseases associated with DLX6 include rapp-hodgkin syndrome and split foot. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DLX5.

Gene Wiki entry for DLX6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLX6 Gene

Genomics for DLX6 Gene

Regulatory Elements for DLX6 Gene

Promoters for DLX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLX6 Gene

97,005,548 bp from pter
97,011,040 bp from pter
5,493 bases
Plus strand

Genomic View for DLX6 Gene

Genes around DLX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLX6 Gene

Proteins for DLX6 Gene

  • Protein details for DLX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein DLX-6
    Protein Accession:
    Secondary Accessions:
    • A4D1I2
    • B3KSQ0
    • J3KR92
    • Q3ZAR6
    • Q9UPL2

    Protein attributes for DLX6 Gene

    175 amino acids
    Molecular mass:
    19708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLX6 Gene


neXtProt entry for DLX6 Gene

Proteomics data for DLX6 Gene at MOPED

Post-translational modifications for DLX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLX6 Gene

Domains & Families for DLX6 Gene

Gene Families for DLX6 Gene

Suggested Antigen Peptide Sequences for DLX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the distal-less homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the distal-less homeobox family.
genes like me logo Genes that share domains with DLX6: view

Function for DLX6 Gene

Molecular function for DLX6 Gene

GENATLAS Biochemistry:
Drosophila distal less homolog Dlx6,homeo domain encoding gene,expressed in brain and skeleton
genes like me logo Genes that share phenotypes with DLX6: view

Animal Models for DLX6 Gene

MGI Knock Outs for DLX6:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLX6 Gene

Localization for DLX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLX6 Gene

Subcellular locations from

Jensen Localization Image for DLX6 Gene COMPARTMENTS Subcellular localization image for DLX6 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DLX6 Gene

Pathways & Interactions for DLX6 Gene

SuperPathways for DLX6 Gene

No Data Available

Interacting Proteins for DLX6 Gene

Gene Ontology (GO) - Biological Process for DLX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development TAS 7907794
GO:0030326 embryonic limb morphogenesis IEA --
GO:0030855 epithelial cell differentiation IEA --
GO:0048646 anatomical structure formation involved in morphogenesis IEA --
genes like me logo Genes that share ontologies with DLX6: view

No data available for Pathways by source and SIGNOR curated interactions for DLX6 Gene

Drugs & Compounds for DLX6 Gene

No Compound Related Data Available

Transcripts for DLX6 Gene

mRNA/cDNA for DLX6 Gene

Unigene Clusters for DLX6 Gene

Distal-less homeobox 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLX6 Gene

No ASD Table

Relevant External Links for DLX6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLX6 Gene

mRNA expression in normal human tissues for DLX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLX6 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x11.1), Brain - Nucleus accumbens (basal ganglia) (x9.8), Brain - Caudate (basal ganglia) (x9.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for DLX6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DLX6 Gene

SOURCE GeneReport for Unigene cluster for DLX6 Gene Hs.249196

genes like me logo Genes that share expression patterns with DLX6: view

Protein tissue co-expression partners for DLX6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DLX6 Gene

Orthologs for DLX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLX6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DLX6 35
  • 90.28 (n)
  • 90 (a)
DLX6 36
  • 98 (a)
(Canis familiaris)
Mammalia DLX6 35
  • 95.21 (n)
  • 98.85 (a)
DLX6 36
  • 76 (a)
(Mus musculus)
Mammalia Dlx6 35
  • 92.72 (n)
  • 96.93 (a)
Dlx6 16
Dlx6 36
  • 96 (a)
(Pan troglodytes)
Mammalia DLX6 35
  • 99.09 (n)
  • 99.32 (a)
DLX6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dlx6 35
  • 94.07 (n)
  • 99.58 (a)
(Monodelphis domestica)
Mammalia DLX6 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia DLX6 36
  • 89 (a)
(Gallus gallus)
Aves DLX6 35
  • 82.65 (n)
  • 86.52 (a)
DLX6 36
  • 93 (a)
(Anolis carolinensis)
Reptilia DLX6 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494171 35
  • 58.68 (n)
  • 57.02 (a)
Str.15888 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.262 35
(Danio rerio)
Actinopterygii dlx6a 35
  • 71.26 (n)
  • 79.76 (a)
dlx6a 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dll 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea ceh-43 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for DLX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLX6 Gene

Gene Tree for DLX6 (if available)
Gene Tree for DLX6 (if available)

Paralogs for DLX6 Gene

(20) SIMAP similar genes for DLX6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLX6: view

Variants for DLX6 Gene

Structural Variations from Database of Genomic Variants (DGV) for DLX6 Gene

Variant ID Type Subtype PubMed ID
nsv824221 CNV Gain 20364138

Variation tolerance for DLX6 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLX6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DLX6 Gene

Disorders for DLX6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DLX6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rapp-hodgkin syndrome
  • orofacial cleft 8
split foot
split hand-split foot malformation
  • split hand foot malformation
rett syndrome
  • rett syndrome, preserved speech variant
- elite association - COSMIC cancer census association via MalaCards
Search DLX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLX6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DLX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLX6 Gene

Publications for DLX6 Gene

  1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PMID: 7907794) Simeone A. … Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Expression analysis and mutation detection of DLX5 and DLX6 in autism. (PMID: 19195802) Nakashima N. … Momoi M.Y. (Brain Dev. 2010) 3 23
  3. DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. (PMID: 17701895) SchA1le B. … Francke U. (Am. J. Hum. Genet. 2007) 3 23
  4. No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. (PMID: 12707945) Nabi R. … Huq A.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23
  5. Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans. (PMID: 24459211) Lango Allen H. … Ellard S. (J. Med. Genet. 2014) 3

Products for DLX6 Gene

Sources for DLX6 Gene

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