Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DLX6 Gene

protein-coding   GIFtS: 51
GCID: GC07P096634

Distal-Less Homeobox 6

(Previous name: distal-less homeo box 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Distal-Less Homeobox 61 2
Distal-Less Homeo Box 61 2
Homeobox Protein DLX-62

External Ids:    HGNC: 29191   Entrez Gene: 17502   Ensembl: ENSG000000063777   OMIM: 6000305   UniProtKB: P561793   

Export aliases for DLX6 gene to outside databases

Previous GC identifers: GC07P095170 GC07P096233 GC07P096247 GC07P096279 GC07P096473 GC07P091222


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DLX6 Gene:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less
gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and
craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the
long arm of chromosome 7. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLX6 Gene:
DLX6 (distal-less homeobox 6) is a protein-coding gene. Diseases associated with DLX6 include rapp-hodgkin syndrome, and split foot. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

Gene Wiki entry for DLX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLX6 gene promoter:
         E2F-3a   E2F-4   AP-1   ATF-2   E2F-2   PPAR-gamma1   E2F-1   E2F   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX6 promoter sequence
   Search Chromatin IP Primers for DLX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

DLX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P096634:  view genomic region     (about GC identifiers)

Start:
96,634,860 bp from pter      End:
96,640,352 bp from pter
Size:
5,493 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 95,957,784-95,962,846     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DLX6_HUMAN, P56179 (See protein sequence)
Recommended Name: Homeobox protein DLX-6  
Size: 175 amino acids; 19708 Da
Developmental stage: First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic
vesicles and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing
forebrain in primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos,
expressed in the brain and bones, and also in all skeletal structures of midgestation embryos after the first
cartilage formation, and expression progressively declines in both brain and skeleton in day 15 embryos
Secondary accessions: A4D1I2 B3KSQ0 J3KR92 Q3ZAR6 Q9UPL2
Alternative splicing: 3 isoforms:  P56179-1   P56179-2   P56179-3   

Explore the universe of human proteins at neXtProt for DLX6: NX_P56179

Explore proteomics data for DLX6 at MOPED


See DLX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005213.3  
ENSEMBL proteins: 
 ENSP00000428480   ENSP00000451635   ENSP00000007660  

DLX6 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for DLX6
OriGene Custom MassSpec
OriGene Custom Protein Services for DLX6
GenScript Custom Purified and Recombinant Proteins Services for DLX6
Novus Biologicals DLX6 Proteins
Novus Biologicals DLX6 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for DLX6

DLX6 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DLX6
Novus Biologicals DLX6 Antibodies
Abcam antibodies for DLX6
Cloud-Clone Corp. Antibodies for DLX6
Search ThermoFisher Antibodies for DLX6
LSBio Antibodies in human, mouse, rat for DLX6

DLX6 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DLX6
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DLX6
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DLX6
Cloud-Clone Corp. CLIAs for DLX6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

5 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR000047 HTH_motif
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P56179

ProtoNet protein and cluster: P56179

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: DLX6_HUMAN, P56179
Similarity: Belongs to the distal-less homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


DLX6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:
     Genatlas biochemistry entry for DLX6:
Drosophila distal less homolog Dlx6,homeo domain encoding gene,expressed in brain and skeleton

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding ----
     
DLX6 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for DLX6:
 Decreased Hepatitis C virus re 

     12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dlx6):
 craniofacial  digestive/alimentary  embryogenesis  growth/size/body  hearing/vestibular/ear 
 integument  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
 skeleton  vision/eye 

DLX6 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLX6
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLX6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX6
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX6

miRNA
Products:
    
miRTarBase miRNAs that target DLX6:
hsa-mir-92a-3p (MIRT049253), hsa-mir-148b-3p (MIRT019311)

Block miRNA regulation of human, mouse, rat DLX6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DLX6 (see all 36):
hsa-miR-596 hsa-miR-4272 hsa-miR-550a* hsa-miR-548l hsa-miR-4275 hsa-miR-10b* hsa-miR-508-5p hsa-miR-3116
SwitchGear 3'UTR luciferase reporter plasmidDLX6 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DLX6
Predesigned siRNA for gene silencing in human, mouse, rat DLX6

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DLX6

Clone
Products:
     
OriGene clones in human, mouse for DLX6 (see all 6)
OriGene ORF clones in mouse, rat for DLX6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DLX6 (NM_005222)
Sino Biological Human cDNA Clone for DLX6
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX6

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DLX6
ESI BIO PureStem Progenitor for DLX6: 
PureStem MEL2, NCr-fac Progenitor
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
DLX6_HUMAN, P56179: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

DLX6 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus




    Pathway & Disease-focused RT2 Profiler PCR Array including DLX6: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for DLX6

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for DLX6 (ENSP000000076604) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
DLX2ENSP000002341984STRING: ENSP00000234198
TP63ENSP000002647314STRING: ENSP00000264731
TP73ENSP000003675454STRING: ENSP00000367545
CBX8ENSP000002693854STRING: ENSP00000269385
TP53ENSP000002693054STRING: ENSP00000269305
About this table

Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001501skeletal system development TAS7907794
GO:0006355regulation of transcription, DNA-templated ----
GO:0007399nervous system development TAS7907794
GO:0030326embryonic limb morphogenesis IEA--
GO:0030855epithelial cell differentiation IEA--

DLX6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DLX6



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DLX6 gene: 
NM_005222.3  

Unigene Cluster for DLX6:

Distal-less homeobox 6
Hs.249196  [show with all ESTs]
Unigene Representative Sequence: NM_005222
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000518156(uc022ahu.1) ENST00000493273 ENST00000555308 ENST00000007660

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DLX6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DLX6 (see all 36):
hsa-miR-596 hsa-miR-4272 hsa-miR-550a* hsa-miR-548l hsa-miR-4275 hsa-miR-10b* hsa-miR-508-5p hsa-miR-3116
SwitchGear 3'UTR luciferase reporter plasmidDLX6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DLX6
Predesigned siRNA for gene silencing in human, mouse, rat DLX6
Clone
Products:
     
OriGene clones in human, mouse for DLX6 (see all 6)
OriGene ORF clones in mouse, rat for DLX6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DLX6 (NM_005222)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX6
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for DLX6
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DLX6
  QuantiTect SYBR Green Assays in human, mouse, rat DLX6
  QuantiFast Probe-based Assays in human, mouse, rat DLX6

Additional mRNA sequence: 

AK094086.1 BC069363.1 BC103688.1 BC103689.1 BC103690.1 BC109381.1 

4 DOTS entries:

DT.452117  DT.101961765  DT.421941  DT.100801418 

Selected AceView cDNA sequences (see all 26):

F11981 BX281177 F09629 F13543 AI859314 BC069363 AA300186 AK094086 
BX327009 BU616500 CF994779 BX115138 AA077087 T65197 BX353127 AA040413 
BX374960 AA040332 AA300187 AA040402 AI961486 T65128 AW514987 BX353128 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DLX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DLX6 Expression
About this image


DLX6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 14 entries
         Hypertrophic Chondrocytes Caudal Endochondral Bones
         Mandibular Process
         HyStem+TGFbeta3+GDF5-induced MEL2 cells
 
 Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
         Prechondrocytes Synchondroses
         HyStem+TGFbeta3+GDF5-induced MEL2 cells
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
         Cranial Neural Crest Cells Branchial Arch 1
         PureStem MEL2, NCr-fac Progenitor
 
 Head Mesenchyme (Muscoskeletal System)    fully expand to see all 6 entries
         Cranial Neural Crest Cells Branchial Arch 1
 
 Ectoderm (Gastrulation Derivatives)
         Preplacodal Ectoderm Cells Preplacodal Ectoderm
DLX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DLX6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.249196
    Pathway & Disease-focused RT2 Profiler PCR Array including DLX6: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for DLX6
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DLX6
QuantiTect SYBR Green Assays in human, mouse, rat DLX6
QuantiFast Probe-based Assays in human, mouse, rat DLX6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for DLX6 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dlx61 , 5 distal-less homeobox 61, 5 92.72(n)1
96.93(a)1
  6 (2.83 cM)5
133961  NM_010057.21  NP_034187.11 
 68633345 
chicken
(Gallus gallus)
Aves DLX61 distal-less homeobox 6 82.65(n)
86.52(a)
  772070  NM_001080890.1  NP_001074359.1 
lizard
(Anolis carolinensis)
Reptilia DLX66
distal-less homeobox 6
88(a)
1 ↔ 1
6(23237333-23243802)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2622 Xenopus mRNA for homeodomain homologous to Drosophila more 81.28(n)    D10259.1 
zebrafish
(Danio rerio)
Actinopterygii dlx6a2 distal-less homeobox gene 6a 74.25(n)   30586  NM_131323.1 
fruit fly
(Drosophila melanogaster)
Insecta Dll6
Distal-less
28(a)
1 → many
2R(20702353-20722686)
worm
(Caenorhabditis elegans)
Secernentea ceh-436
Protein CEH-43 (ceh-43) mRNA, complete cds
30(a)
1 → many
III(4446635-4449943) WBGene00000463


ENSEMBL Gene Tree for DLX6 (if available)
TreeFam Gene Tree for DLX6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DLX6 gene
DLX22  BARX12  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  
MNX12  BARX22  DLX12  DLX32  LBX22  NKX1-22  BSX2  DLX52  
DLX42  LBX12  MSX22  MSX12  
Selected SIMAP similar genes for DLX6 using alignment to 2 protein entries:     DLX6_HUMAN (see all proteins) (see all similar genes):
DLX1    MNX1    HMX2    NKX2-5    DLX2    DLX5
PITX2    HOXB1    DLX4    BARX1    CDX1    DLX3
MSX1    NKX1-1    HOXA4    NANOG    NKX2-6    ARX

DLX6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus
Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DLX6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv824221CNV Gain20364138

Human Gene Mutation Database (HGMD): DLX6
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DLX6
DNA2.0 Custom Variant and Variant Library Synthesis for DLX6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 600030    OMIM disorders: --

8 diseases for DLX6:    
About MalaCards
rapp-hodgkin syndrome    split foot    rett syndrome    split hand
hypospadias    lymphoblastic leukemia    leukemia    breast cancer

1 disease from the University of Copenhagen DISEASES database for DLX6:
Rett syndrome

DLX6 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for DLX6 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rett syndrome 57.6 1 17701895 (1)

Genetic Association Database (GAD): DLX6
Human Genome Epidemiology (HuGE) Navigator: DLX6 (3 documents)

Export disorders for DLX6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DLX6 gene, integrated from 10 sources (see all 35):
(articles sorted by number of sources associating them with DLX6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 3, 9 Simeone A....Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  7. DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. (PubMed id 17701895)1, 9 SchA1le B....Francke U. (Am. J. Hum. Genet. 2007)
  8. Expression analysis and mutation detection of DLX5 and DLX6 in autism. (PubMed id 19195802)1, 9 Nakashima N....Momoi M.Y. (amp 2010)
  9. No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. (PubMed id 12707945)1, 9 Nabi R....Huq A.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
  10. A 0.7a88Mb de novo duplication at 7q21.3 including the genes DLX5 and DLX6 in a patient with split-hand/split-foot malformation. (PubMed id 23169702)1 Velinov M....Iqbal M.A. (Am. J. Med. Genet. A 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 1750 HGNC: 2919 AceView: DLX6 Ensembl:ENSG00000006377 euGenes: HUgn1750
ECgene: DLX6 H-InvDB: DLX6

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DLX6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DLX6 gene:
Search GeneIP for patents involving DLX6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DLX6  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DLX6  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for DLX6  
 OriGene qSTAR qPCR primer pairs in human, mouse for DLX6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for DLX6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DLX6   OriGene Custom Protein Services for DLX6  

 
 
 Block miRNA regulation of human, mouse, rat DLX6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DLX6
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLX6 Predesigned siRNA for gene silencing in human, mouse, rat DLX6
 QuantiFast Probe-based Assays in human, mouse, rat DLX6 QuantiTect SYBR Green Assays in human, mouse, rat DLX6
 PCR Arrays including human, mouse, rat DLX6 Search Chromatin IP Primers for DLX6
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DLX6  Search GeneGlobe Interaction Network for DLX6
 Regulatory tfbs in DLX6 promoter
 GenScript Custom Purified and Recombinant Proteins Services for DLX6 GenScript cDNA clones with any tag delivered in your preferred vector for DLX6
 GenScript Custom Assay Services for DLX6 GenScript Custom overexpressing Cell Line Services for DLX6
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DLX6
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for DLX6
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DLX6 antibodies
 DLX6 proteins
 DLX6 lysates
 Antibodies for DLX6
 See all of Abcam's Antibodies, Kits and Proteins for DLX6
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for DLX6
 Antibodies for DLX6
 ELISAs for DLX6
 CLIAs for DLX6



 PureStem Progenitor for DLX6: PureStem MEL2, NCr-fac Progenitor
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX6
 SwitchGear 3'UTR luciferase reporter plasmids for DLX6
 SwitchGear Promoter luciferase reporter plasmids for DLX6
 Search ThermoFisher Antibodies for DLX6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX6
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLX6
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLX6
 LSBio Antibodies in human, mouse, rat for DLX6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DLX6 gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4