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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLX4 Gene

protein-coding   GIFtS: 56
GCID: GC17P048046

Distal-Less Homeobox 4


(Previous symbols: DLX7, DLX9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Distal-Less Homeobox 41 2     Homeobox Protein DLX-82 3
DLX71 2 3 5     BP12 3
DLX91 2 3     Distal-Less Homeo Box 72
DLX82 3 5     Distal-Less Homeo Box 92
Beta Protein 12 3     Homeobox Protein DLX-42
Homeobox Protein DLX-72 3     

External Ids:    HGNC: 29171   Entrez Gene: 17482   Ensembl: ENSG000001088137   OMIM: 6019115   UniProtKB: Q929883   

Export aliases for DLX4 gene to outside databases

Previous GC identifers: GC17P047757 GC17P050526 GC17P048388 GC17P048521 GC17P045401 GC17P043411


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLX4 Gene:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with
Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of
Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx)
family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role
in forebrain and craniofacial development. Three transcript variants have been described for this gene, however,
the full length nature of one variant has not been described. Studies of the two splice variants revealed that
one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DLX4 Gene: 
DLX4 (distal-less homeobox 4) is a protein-coding gene. Diseases associated with DLX4 include dental enamel hypoplasia, and adult acute lymphocytic leukemia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
Function: May play a role in determining the production of hemoglobin S. May act as a repressor

Gene Wiki entry for DLX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLX4 gene promoter:
         HOXA9   HOXA9B   Spz1   HOXA5   Lmo2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

DLX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048046:  view genomic region     (about GC identifiers)

Start:
48,046,334 bp from pter      End:
48,052,323 bp from pter
Size:
5,990 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988 (See protein sequence)
Recommended Name: Homeobox protein DLX-4  
Size: 240 amino acids; 26263 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DTX2 D3DTX3 O60480 Q13265 Q6PJK0 Q9HBE0
Alternative splicing: 3 isoforms:  Q92988-1   Q92988-2   Q92988-3   (Ref.1 (AAC50942) sequence is in conflict in positions: 8:P->H, 15:Y->N)

Explore the universe of human proteins at neXtProt for DLX4: NX_Q92988

Explore proteomics data for DLX4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92988

  • DLX4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DLX4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001925.2  NP_612138.1  

    ENSEMBL proteins: 
     ENSP00000240306   ENSP00000474516   ENSP00000410622  

    Human Recombinant Protein Products for DLX4: 
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    OriGene Protein Over-expression Lysate for DLX4
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    Novus Biologicals DLX4 Proteins
    Novus Biologicals DLX4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DLX4
    Cloud-Clone Corp. Proteins for DLX4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11069021

    DLX4 for ontologies           About GeneDecksing



    DLX4 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for DLX4 
    Cloud-Clone Corp. CLIAs for DLX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q92988

    ProtoNet protein and cluster: Q92988

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    DLX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLX4_HUMAN, Q92988
    Function: May play a role in determining the production of hemoglobin S. May act as a repressor

         Genatlas biochemistry entry for DLX4:
    Drosophila distal less homolog Dlx4,homeo domain encoding gene,expressed in extra-embryonic tissues such as
    placenta,clustering with DLX3 (? and seven)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11069021
    GO:0005515protein binding IPI17474147
    GO:0043565sequence-specific DNA binding IDA9073066
         
    DLX4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DLX4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DLX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX4
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX4:
    hsa-miR-1273d hsa-miR-3140-3p hsa-miR-2355-5p hsa-miR-516b hsa-miR-342-5p hsa-miR-657 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidDLX4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DLX4

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    GenScript: all cDNA clones in your preferred vector (see all 2): DLX4 (NM_001934)
    Sino Biological Human cDNA Clone for DLX4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX4
    Sirion Biotech Customized lentivirus for stable overexpression of DLX4 
                         Customized lentivirus expression plasmids for stable overexpression of DLX4 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/127 Interacting proteins for DLX4 (Q929881, 2, 3 ENSP000002403064) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1752755,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent NAS11069021
    GO:0007275multicellular organismal development IEA--

    DLX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLX4

    Search CenterWatch for drugs/clinical trials and news about DLX4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DLX4 gene (2 alternative transcripts): 
    NM_001934.3  NM_138281.2  

    Unigene Cluster for DLX4:

    Distal-less homeobox 4
    Hs.591167  [show with all ESTs]
    Unigene Representative Sequence: NM_138281
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503410 ENST00000240306(uc002ipv.3 uc002ipw.3) ENST00000505318
    ENST00000503276 ENST00000411890
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX4
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX4:
    hsa-miR-1273d hsa-miR-3140-3p hsa-miR-2355-5p hsa-miR-516b hsa-miR-342-5p hsa-miR-657 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidDLX4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DLX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX4
    Clone
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    OriGene clones in human, mouse for DLX4 (see all 11)
    OriGene ORF clones in mouse, rat for DLX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DLX4 (NM_001934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX4
    Sirion Biotech Customized lentivirus for stable overexpression of DLX4 
                         Customized lentivirus expression plasmids for stable overexpression of DLX4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DLX4
    OriGene qSTAR qPCR primer pairs in human, mouse for DLX4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DLX4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX4

    Additional mRNA sequence: 

    AF254115.1 AK311489.1 BC016145.1 BT006978.1 U31762.1 U73328.1 

    5 DOTS entries:

    DT.91979461  DT.442552  DT.92068039  DT.95264035  DT.100684722 

    24/47 AceView cDNA sequences (see all 47):

    BQ212542 BX113580 BC014419 BX105774 BC005812 U31762 AI130737 R32312 
    U73328 AF254115 NM_001934 BG676282 CB960123 BT006978 BG329276 AA256410 
    CB131875 NM_138281 AI241525 BQ026455 BE883924 BC016145 BF435771 AU185209 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DLX4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:        -     -           -     -                                       
    SP2:                          -     -     -     -                           
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for DLX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLX4 expression in normal human tissues (normalized intensities)      DLX4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGGACAC
    DLX4 Expression
    About this image


    DLX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 2
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 2
     
     Cartilage (Muscoskeletal System)
             synovial membrane   
     
     Placenta (Extraembryonic Tissues)

    See DLX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLX4

    SOURCE GeneReport for Unigene cluster: Hs.591167

    UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
    Tissue specificity: Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver

        SABiosciences Expression via Pathway-Focused PCR Array including DLX4: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DLX4 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlx41 , 5 distal-less homeobox 41, 5 81.51(n)1
    76.47(a)1
      11 (59.01 cM)5
    133941  NM_007867.41  NP_031893.31 
     951404565 
    lizard
    (Anolis carolinensis)
    Reptilia DLX46
    distal-less homeobox 4
    56(a)
    1 ↔ 1
    6(77068112-77091500)
    zebrafish
    (Danio rerio)
    Actinopterygii dlx4a6
    dlx4b6
    distal-less homeobox gene 4b
    41(a)
    37(a)
    1 ↔ many
    1 ↔ many
    3(34755372-34766717)
    12(6057527-6066666)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-436
    Homeobox protein ceh-43
    23(a)
    1 → many
    III(4446635-4449943)


    ENSEMBL Gene Tree for DLX4 (if available)
    TreeFam Gene Tree for DLX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLX4 gene
    DLX22  BARX12  NKX1-12  VENTX2  BARHL12  BARHL22  BARX22  DLX12  
    DLX32  LBX22  NKX1-22  BSX2  DLX52  DLX62  LBX12  MSX22  
    MSX12  
    3 SIMAP similar genes for DLX4 using alignment to 1 protein entry:     DLX4_HUMAN:
    DLX6    DLX3    DLX1

    DLX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/141 SNPs in DLX4 are shown (see all 141)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105958411,2
    C--48045577(+) CATGTTGT/-ATTTG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs711469551,2
    C--48046626(+) GGGGGG/-CACCC 1 -- ut513Minor allele frequency- -:0.17NA CSA 6
    rs602430531,2
    C--48051347(+) TGCAC-/AGCCCAGGACCCA
    GGCAGTCCACCTGCAC
    CCCTT
    2 -- ut310--------
    rs1882832141,2
    --49057937(+) AAAAAC/TTCACC 1 -- us2k10--------
    rs568664121,2
    C,F--49058143(+) TCCTCC/TTTCTT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs9190911,2
    C,F,A,H--49058224(+) TTAACC/ATCCAG 1 -- us2k115Minor allele frequency- A:0.02NS EA NA WA CSA 556
    rs1441401401,2
    --49058599(+) TGGCA-/GGTTTA 1 -- us2k10--------
    rs175511031,2
    C,F,H--49058800(+) GCTAAT/CTCATC 1 -- us2k117Minor allele frequency- C:0.03NA NS EA 2024
    rs1927449401,2
    --49058824(+) ATGTAC/TACACA 1 -- us2k10--------
    rs728391661,2
    C,F--49058866(+) TGAACC/TTCTCT 1 -- us2k12Minor allele frequency- T:0.05WA NA 238

    HapMap Linkage Disequilibrium report for DLX4 (48046334 - 48052323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DLX4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833474CNV Loss17160897
    nsv908588CNV Loss21882294
    nsv908589CNV Loss21882294
    esv24299CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601911    OMIM disorders: --

    20/24 diseases for DLX4 (see all 24):    About MalaCards
    dental enamel hypoplasia    adult acute lymphocytic leukemia    acute lymphocytic leukemia    sickle cell disease
    acute promyelocytic leukemia    choriocarcinoma    charcot-marie-tooth disease    tooth disease
    cleft lip    intrahepatic cholangiocarcinoma    prostate adenocarcinoma    cholangiocarcinoma
    acute lymphoblastic leukemia    fibrosarcoma    herpes simplex    acute leukemia
    lymphoblastic leukemia    breast cancer    glioblastoma    leukemia


    DLX4 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for DLX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    charcot-marie-tooth disease 68.4 1 12542510 (1)
    choriocarcinoma 51.9 4 15975650 (3), 9481790 (1)
    sickle cell disease 29.2 2 11909945 (1)
    cancer lung 11.8 16 16939914 (4)
    leukemia 9.28 2 15975650 (1), 11707330 (1)
    breast cancer 6.2 20 17626745 (10), 19119308 (4), 15248928 (4), 15975650 (1)
    metastasis 0 4 17260014 (1), 15248928 (1)
    tumors 0 3 15248928 (2), 15975650 (1)
    cancer 0 5 16939914 (1)

    Genetic Association Database (GAD): DLX4
    Human Genome Epidemiology (HuGE) Navigator: DLX4 (2 documents)

    Export disorders for DLX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLX4 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with DLX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BP1, a homeodomain-containing isoform of DLX4, represses the beta- globin gene. (PubMed id 11909945)1, 2, 9 Chase M.B.... Berg P.E. (2002)
    2. Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. (PubMed id 9073066)1, 2, 9 Quinn L.M.... Kalionis B. (1997)
    3. Genomic analysis of a new mammalian distal-less gene: Dlx7. (PubMed id 8975708)1, 2, 9 Nakamura S.... Ruddle F.H. (1996)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Genomic structure and functional control of the Dlx3-7 bigene cluster. (PubMed id 11792834)1, 2 Sumiyama K.... Ruddle F.H. (2002)
    8. BP1, a new homeobox gene, is frequently expressed in acute leukemias. (PubMed id 11069021)1, 2 Haga S.B.... Berg P.E. (2000)
    9. Identification of a mutation in DLX3 associated with tricho-dento- osseous (TDO) syndrome. (PubMed id 9467018)1, 2 Price J.A.... Hart T.C. (1998)
    10. Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. (PubMed id 11707330)1, 9 Fu S....Berg P.E. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1748 HGNC: 2917 AceView: DLX4 Ensembl:ENSG00000108813 euGenes: HUgn1748
    ECgene: DLX4 H-InvDB: DLX4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLX4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DLX4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DLX4 gene:
    Search GeneIP for patents involving DLX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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