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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLX4 Gene

protein-coding   GIFtS: 55
GCID: GC17P048046

distal-less homeobox 4


(Previous symbols: DLX7, DLX9)
 Explore 29 diseases affiliated with
DLX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DLX4    

Aliases
for DLX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Distal-Less Homeobox 41 2     Homeobox Protein DLX-72 3
DLX71 2 3 5     Homeobox Protein DLX-82 3
DLX81 2 3 5     Distal-Less Homeo Box 72
BP11 2 3     Distal-Less Homeo Box 92
DLX91 2 3     Homeobox Protein DLX-42
Beta Protein 12 3     

External Ids:    HGNC: 29171   Entrez Gene: 17482   Ensembl: ENSG000001088137   OMIM: 6019115   UniProtKB: Q929883   

Export aliases for DLX4 gene to outside databases

Previous GC identifers: GC17P047757 GC17P050526 GC17P048388 GC17P048521 GC17P045401 GC17P043411


Summaries
for DLX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DLX4:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with
Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of
Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of
genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain
and craniofacial development. Three transcript variants have been described for this gene, however, the full length
nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform
functions as a repressor of the beta-globin gene while the other isoform lacks that function. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
Function: May play a role in determining the production of hemoglobin S. May act as a repressor

Gene Wiki entry for DLX4


Genomic Views
for DLX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLX4 gene promoter:
         HOXA9   HOXA9B   Spz1   HOXA5   Lmo2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

DLX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048046:  view genomic region     (about GC identifiers)

Start:
 48,046,334 bp from pter      End:
 48,052,323 bp from pter
Size:
 5,990 bases      Orientation:
 plus strand

Proteins
for DLX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988 (See protein sequence)
Recommended Name: Homeobox protein DLX-4  
Size: 240 amino acids; 26263 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DTX2 D3DTX3 O60480 Q13265 Q6PJK0 Q9HBE0
Alternative splicing: 3 isoforms:  Q92988-1   Q92988-2   Q92988-3   (Ref.1 (AAC50942) sequence is in conflict in positions: 8:P->H, 15:Y->N)

Explore the universe of human proteins at neXtProt for DLX4: NX_Q92988

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92988

    • DLX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001925.2  NP_612138.1  

    ENSEMBL proteins: 
     ENSP00000240306   ENSP00000410622  

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    OriGene Protein Over-expression Lysate (see all 2): DLX4
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    Novus Biologicals DLX4 Proteins
    Novus Biologicals DLX4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DLX4
    Uscn Proteins for DLX4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11069021


    DLX4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DLX4

    Protein Domains /
    Families
    for DLX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DLX4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q92988

    ProtoNet protein and cluster: Q92988

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for DLX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
    Function: May play a role in determining the production of hemoglobin S. May act as a repressor

         Genatlas biochemistry entry for DLX4:
    Drosophila distal less homolog Dlx4,homeo domain encoding gene,expressed in extra-embryonic tissues such as
    placenta,clustering with DLX3 (? and seven)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX4
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX4:
    hsa-miR-1273d hsa-miR-3140-3p hsa-miR-2355-5p hsa-miR-516b hsa-miR-342-5p hsa-miR-657 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: DLX4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX4 (see all 7)
    OriGene shRNA RFP: DLX4
    OriGene siRNA: DLX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX4

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX4 

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    Search LifeMap BioReagents cell lines for DLX4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11069021
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IDA9073066


    DLX4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for DLX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/127 Interacting proteins for DLX4 (Q929881, 2, 3 ENSP000002403064) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1752755,EBI-3448658 I2D: score=1 STRING: ENSP00000288986
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent NAS11069021
    GO:0007275multicellular organismal development IEA--


    DLX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DLX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLX4
    Search CenterWatch for drugs/clinical trials and news about DLX4 

    Transcripts
    for DLX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DLX4 gene (2 alternative transcripts): 
    NM_001934.3  NM_138281.2  

    Unigene Cluster for DLX4:

    Distal-less homeobox 4
    Hs.591167  [show with all ESTs]
    Unigene Representative Sequence: NM_138281
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503410 ENST00000240306(uc002ipv.3 uc002ipw.3) ENST00000505318
    ENST00000503276 ENST00000411890

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX4:
    hsa-miR-1273d hsa-miR-3140-3p hsa-miR-2355-5p hsa-miR-516b hsa-miR-342-5p hsa-miR-657 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: DLX4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX4 (see all 7)
    OriGene shRNA RFP: DLX4
    OriGene siRNA: DLX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX4
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DLX4 (NM_001934)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX4

    Additional cDNA sequence: 

    AF254115.1 AK311489.1 BC016145.1 BT006978.1 U31762.1 U73328.1 

    5 DOTS entries:

    DT.91979461  DT.442552  DT.92068039  DT.95264035  DT.100684722 

    24/47 AceView cDNA sequences (see all 47):

    BX105774 BC014419 BX113580 BQ212542 R32312 AF254115 AA256410 BG676282 
    NM_001934 BG329276 U73328 BT006978 CF994898 AI130737 BF435771 BE883924 
    AU185209 CB131875 U31762 BC016145 AI241525 CB960123 BG329392 BC005812 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DLX4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:        -     -           -     -                                       
    SP2:                          -     -     -     -                           
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for DLX4

    Expression
    for DLX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACTGGACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DLX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 2Cranial Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

    See DLX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLX4

    SOURCE GeneReport for Unigene cluster: Hs.591167

    UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
    Tissue specificity: Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver

        SABiosciences Expression via Pathway-Focused PCR Array including DLX4: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for DLX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DLX4 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DLX46
    		 --
    		 58(a)
    		 1 ↔ 1
    		 6(77080671-77091500)
    zebrafish
    (Danio rerio)    		 Actinopterygii dlx4a6
    dlx4b6
    (see all 3)    		 distal-less homeobox gene 4b
    (see all 3)    		 42(a)
    41(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 3(34755372-34766717)
    12(6057527-6066666)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dll6
    		 Distal-less
    		 22(a)
    		 possible ortholog
    		 2R(20702353-20722686)


    ENSEMBL Gene Tree for DLX4 (if available)
    TreeFam Gene Tree for DLX4 (if available) 

    Paralogs
    for DLX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLX4 gene
    DLX22  BARX12  BSX2  DLX52  DLX62  BARHL22  BARHL12  BARX22  
    DLX12  MSX22  MSX12  DLX32  
    3 SIMAP similar genes for DLX4 using alignment to 1 protein entry:     DLX4_HUMAN:
    DLX6    DLX3    DLX1

    DLX4 for paralogs           About GeneDecksing



    Genomic Variants
    for DLX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 NCBI SNPs in DLX4 are shown (see all 109)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs568664121,2
    		C,F,--43409616(+) TCCTCC/TTTCTT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs175511031,2
    		C,F,H,--43410273(+) GCTAAT/CTCATC 1 -- us2k117Minor allele frequency- C:0.03NA NS EA 2024
    rs728391661,2
    		C,F,--43410339(+) TGAACC/TTCTCT 1 -- us2k12Minor allele frequency- T:0.05WA NA 238
    rs728391671,2
    		C,F,--43410352(+) TTATAG/CAGGAA 1 -- us2k11Minor allele frequency- C:0.08NA 120
    rs780670031,2
    		F,--43411095(+) CAGCCC/TCCGGG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs561329091,2
    		F,--43411306(+) GTCCCG/AGGGGG 1 -- us2k12Minor allele frequency- A:0.05WA NA 238
    rs777858641,2
    		C,F,--43413355(+) GGGGAA/GTTGCT 2 -- int1 us2k11Minor allele frequency- G:0.07WA 118
    rs773322981,2
    		--43413757(+) GGAAGG/AAACTT 2 -- int1 us2k12Minor allele frequency- A:0.03CSA WA 120
    rs743885761,2
    		--43413949(+) ACAGGC/GGCGGG 2 -- int1 us2k12Minor allele frequency- G:0.12CSA WA 120
    rs116581761,2
    		C,F,H,--43414392(+) CTGGGC/ATGTCC 2 -- int1 us2k17Minor allele frequency- A:0.05NS NA 706

    HapMap Linkage Disequilibrium report for DLX4 (48046334 - 48052323 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DLX4
         1 CNV: 72974

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLX4
    DNA2.0 Custom Variant and Variant Library Synthesis for DLX4

    Disorders / Diseases
    for DLX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DLX4 for disorders           About GeneDecksing

    OMIM gene information: 601911    OMIM disorders: --

    20/29 diseases for DLX4 (see all 29):    About MalaCards
    charcot-marie-tooth disease    dental enamel hypoplasia    cleft lip/palate    cleft lip
    adult acute lymphocytic leukemia    sickle cell disease    tooth disease    acute promyelocytic leukemia
    acute lymphoblastic leukemia    acute lymphocytic leukemia    lymphoblastic leukemia    herpes simplex
    intrahepatic cholangiocarcinoma    inflammatory breast cancer    choriocarcinoma    breast cancer
    leukemia    lymphocytic leukemia    cholangiocarcinoma    fibrosarcoma

    9 Novoseek disease relationships for DLX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    charcot-marie-tooth disease 68.4 1 12542510 (1)
    choriocarcinoma 51.9 4 15975650 (3), 9481790 (1)
    sickle cell disease 29.2 2 11909945 (1)
    cancer lung 11.8 16 16939914 (4)
    leukemia 9.28 2 15975650 (1), 11707330 (1)
    breast cancer 6.2 20 17626745 (10), 19119308 (4), 15248928 (4), 15975650 (1)
    metastasis 0 4 17260014 (1), 15248928 (1)
    tumors 0 3 15248928 (2), 15975650 (1)
    cancer 0 5 16939914 (1)

    Human Genome Epidemiology (HuGE) Navigator: DLX4 (2 documents)

    Export disorders for DLX4 gene to outside databases

    Publications
    for DLX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLX4 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with DLX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. BP1, a homeodomain-containing isoform of DLX4, represses the beta- globin gene. (PubMed id 11909945)1, 2, 9 Chase M.B.... Berg P.E. (2002)
    2. Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. (PubMed id 9073066)1, 2, 9 Quinn L.M.... Kalionis B. (1997)
    3. Genomic analysis of a new mammalian distal-less gene: Dlx7. (PubMed id 8975708)1, 2, 9 Nakamura S.... Ruddle F.H. (1996)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Genomic structure and functional control of the Dlx3-7 bigene cluster. (PubMed id 11792834)1, 2 Sumiyama K.... Ruddle F.H. (2002)
    6. BP1, a new homeobox gene, is frequently expressed in acute leukemias. (PubMed id 11069021)1, 2 Haga S.B.... Berg P.E. (2000)
    7. Identification of a mutation in DLX3 associated with tricho-dento- osseous (TDO) syndrome. (PubMed id 9467018)1, 2 Price J.A.... Hart T.C. (1998)
    8. Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. (PubMed id 11707330)1, 9 Fu S....Berg P.E. (2001)
    9. A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta. (PubMed id 9481790)1, 9 Quinn L.M....Kalionis B. (1998)
    10. Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. (PubMed id 17260014)1, 9 Tomida S....Takahashi T. (2007)

    External Searches for DLX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DLX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1748 HGNC: 2917 AceView: DLX4 Ensembl:ENSG00000108813 euGenes: HUgn1748
    ECgene: DLX4 H-InvDB: DLX4

    Other Databases showing DLX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DLX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DLX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DLX4 gene:
    Search GeneIP for patents involving DLX4

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