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DLX4 Gene

protein-coding   GIFtS: 55
GCID: GC17P048046

Distal-Less Homeobox 4


(Previous symbols: DLX7, DLX9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Distal-Less Homeobox 41 2     Homeobox Protein DLX-82 3
DLX71 2 3 5     BP12 3
DLX91 2 3     Distal-Less Homeo Box 72
DLX82 3 5     Distal-Less Homeo Box 92
Beta Protein 12 3     Homeobox Protein DLX-42
Homeobox Protein DLX-72 3     

External Ids:    HGNC: 29171   Entrez Gene: 17482   Ensembl: ENSG000001088137   OMIM: 6019115   UniProtKB: Q929883   
ORGUL members:         

Export aliases for DLX4 gene to outside databases

Previous GC identifers: GC17P047757 GC17P050526 GC17P048388 GC17P048521 GC17P045401 GC17P043411


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLX4 Gene:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with
Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of
Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx)
family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role
in forebrain and craniofacial development. Three transcript variants have been described for this gene, however,
the full length nature of one variant has not been described. Studies of the two splice variants revealed that
one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DLX4 Gene:
DLX4 (distal-less homeobox 4) is a protein-coding gene. Diseases associated with DLX4 include x-linked charcot-marie-tooth disease, and dental enamel hypoplasia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
Function: May play a role in determining the production of hemoglobin S. May act as a repressor

Gene Wiki entry for DLX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLX4 gene promoter:
         HOXA9   HOXA9B   Spz1   HOXA5   Lmo2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX4 promoter sequence
   Search Chromatin IP Primers for DLX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

DLX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048046:  view genomic region     (about GC identifiers)

Start:
48,046,334 bp from pter      End:
48,052,323 bp from pter
Size:
5,990 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988 (See protein sequence)
Recommended Name: Homeobox protein DLX-4  
Size: 240 amino acids; 26263 Da
Secondary accessions: D3DTX2 D3DTX3 O60480 Q13265 Q6PJK0 Q9HBE0
Alternative splicing: 3 isoforms:  Q92988-1   Q92988-2   Q92988-3   (Ref.1 (AAC50942) sequence is in conflict in positions: 8:P->H, 15:Y->N)

Explore the universe of human proteins at neXtProt for DLX4: NX_Q92988

Explore proteomics data for DLX4 at MOPED


See DLX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001925.2  NP_612138.1  

ENSEMBL proteins: 
 ENSP00000240306   ENSP00000474516   ENSP00000410622  

DLX4 Human Recombinant Protein Products:

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Novus Biologicals DLX4 Proteins
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LSBio Antibodies in human, mouse, rat for DLX4

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Cloud-Clone Corp. ELISAs for DLX4
Cloud-Clone Corp. CLIAs for DLX4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

5 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR000047 HTH_motif
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q92988

ProtoNet protein and cluster: Q92988

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
Similarity: Belongs to the distal-less homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


DLX4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DLX4_HUMAN, Q92988
Function: May play a role in determining the production of hemoglobin S. May act as a repressor

     Genatlas biochemistry entry for DLX4:
Drosophila distal less homolog Dlx4,homeo domain encoding gene,expressed in extra-embryonic tissues such as
placenta,clustering with DLX3 (? and seven)

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity NAS11069021
GO:0005515protein binding IPI17474147
GO:0043565sequence-specific DNA binding IDA9073066
     
DLX4 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLX4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLX4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX4

miRNA
Products:
    
miRTarBase miRNAs that target DLX4:
hsa-mir-769-3p (MIRT039137)

Block miRNA regulation of human, mouse, rat DLX4 using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate DLX4:
hsa-miR-1273d hsa-miR-3140-3p hsa-miR-2355-5p hsa-miR-516b hsa-miR-342-5p hsa-miR-657 hsa-miR-29b-1*
SwitchGear 3'UTR luciferase reporter plasmidDLX4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DLX4
Predesigned siRNA for gene silencing in human, mouse, rat DLX4

Gene Editing
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DNA2.0 Custom Protein Engineering Service for DLX4

Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DLX4 (NM_001934)
Sino Biological Human cDNA Clone for DLX4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX4

Cell Line
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GenScript Custom overexpressing Cell Line Services for DLX4
Browse ESI BIO Cell Lines and PureStem Progenitors for DLX4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DLX4_HUMAN, Q92988: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus NAS11069021

DLX4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including DLX4: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for DLX4

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

Selected Interacting proteins for DLX4 (Q929881, 2, 3 ENSP000002403064) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
InteractantInteraction Details
GeneCardExternal ID(s)
NCK1P163331, 3, ENSP000002889864EBI-1752755,EBI-389883 I2D: score=1 STRING: ENSP00000288986
MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated NAS11069021
GO:0007275multicellular organismal development IEA--

DLX4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DLX4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DLX4 gene (2 alternative transcripts): 
NM_001934.3  NM_138281.2  

Unigene Cluster for DLX4:

Distal-less homeobox 4
Hs.591167  [show with all ESTs]
Unigene Representative Sequence: NM_138281
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000503410 ENST00000240306(uc002ipv.3 uc002ipw.3) ENST00000505318
ENST00000503276 ENST00000411890
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DLX4 using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate DLX4:
hsa-miR-1273d hsa-miR-3140-3p hsa-miR-2355-5p hsa-miR-516b hsa-miR-342-5p hsa-miR-657 hsa-miR-29b-1*
SwitchGear 3'UTR luciferase reporter plasmidDLX4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DLX4
Predesigned siRNA for gene silencing in human, mouse, rat DLX4
Clone
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OriGene clones in human, mouse for DLX4 (see all 11)
OriGene ORF clones in mouse, rat for DLX4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DLX4 (NM_001934)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DLX4
OriGene qSTAR qPCR primer pairs in human, mouse for DLX4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLX4
  QuantiTect SYBR Green Assays in human, mouse, rat DLX4
  QuantiFast Probe-based Assays in human, mouse, rat DLX4

Additional mRNA sequence: 

AF254115.1 AK311489.1 BC016145.1 BT006978.1 U31762.1 U73328.1 

5 DOTS entries:

DT.91979461  DT.442552  DT.92068039  DT.95264035  DT.100684722 

Selected AceView cDNA sequences (see all 47):

BQ212542 BX113580 BC014419 BX105774 AI241525 BC005812 BC016145 AA256410 
BG329276 U73328 BQ026455 CB131875 CF994898 BG479840 R32312 AI130737 
BE883924 BT006978 NM_001934 BF435771 CB960123 AU185209 U31762 AF254115 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DLX4    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1:        -     -           -     -                                       
SP2:                          -     -     -     -                           
SP3:                                                                        
SP4:                                                                        
SP5:                                                                        


ECgene alternative splicing isoforms for DLX4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DLX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACTGGACAC
DLX4 Expression
About this image


DLX4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
         Cranial Neural Crest Cells Branchial Arch 2
 
 Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
         Cranial Neural Crest Cells Branchial Arch 2
 
 Tooth (Integumentary System)    fully expand to see all 2 entries
         Stellate Reticulum Cells Dental Core
 
 Placenta (Extraembryonic Tissues)
DLX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DLX4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591167

UniProtKB/Swiss-Prot: DLX4_HUMAN, Q92988
Tissue specificity: Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver

    Pathway & Disease-focused RT2 Profiler PCR Array including DLX4: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for DLX4
OriGene qSTAR qPCR primer pairs in human, mouse for DLX4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLX4
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QuantiFast Probe-based Assays in human, mouse, rat DLX4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DLX4 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dlx41 , 5 distal-less homeobox 41, 5 80.81(n)1
76.47(a)1
  11 (59.01 cM)5
133941  NM_007867.41  NP_031893.31 
 951404565 
chicken
(Gallus gallus)
Aves DLX46
distal-less homeobox 4
70(a)
1 ↔ 1
27(2998452-3005555)
lizard
(Anolis carolinensis)
Reptilia DLX46
distal-less homeobox 4
55(a)
1 ↔ 1
6(77068112-77091500)
zebrafish
(Danio rerio)
Actinopterygii dlx4a6
dlx4b6
distal-less homeobox gene 4b
46(a)
43(a)
1 ↔ many
1 ↔ many
3(34755372-34766717) ENSDARG00000011956
12(6057527-6066666) ENSDARG00000071560
fruit fly
(Drosophila melanogaster)
Insecta Dll6
Distal-less
25(a)
1 → many
2R(20702353-20722686)
worm
(Caenorhabditis elegans)
Secernentea ceh-436
Protein CEH-43 (ceh-43) mRNA, complete cds
28(a)
1 → many
III(4446635-4449943) WBGene00000463


ENSEMBL Gene Tree for DLX4 (if available)
TreeFam Gene Tree for DLX4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DLX4 gene
DLX22  BARX12  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  
MNX12  BARX22  DLX12  DLX32  LBX22  NKX1-22  BSX2  DLX52  
DLX62  LBX12  MSX22  MSX12  
3 SIMAP similar genes for DLX4 using alignment to 2 protein entries:     DLX4_HUMAN (see all proteins):
DLX6    DLX3    DLX1

DLX4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DLX4 (see all 141)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs105958411,2
C--48045577(+) CATGTTGT/-ATTTG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs711469551,2
C--48046626(+) GGGGGG/-CACCC 1 -- ut513Minor allele frequency- -:0.17NA CSA 6
rs602430531,2
C--48051347(+) TGCAC-/AGCCCAGGACCCA
GGCAGTCCACCTGCAC
CCCTT
2 -- ut310--------
rs1882832141,2
--49057937(+) AAAAAC/TTCACC 1 -- us2k10--------
rs568664121,2
C,F--49058143(+) TCCTCC/TTTCTT 1 -- us2k11Minor allele frequency- T:0.05WA 118
rs9190911,2
C,F,A,H--49058224(+) TTAACC/ATCCAG 1 -- us2k115Minor allele frequency- A:0.02NS EA NA WA CSA 556
rs1441401401,2
--49058599(+) TGGCA-/GGTTTA 1 -- us2k10--------
rs175511031,2
C,F,H--49058800(+) GCTAAT/CTCATC 1 -- us2k117Minor allele frequency- C:0.03NA NS EA 2024
rs1927449401,2
--49058824(+) ATGTAC/TACACA 1 -- us2k10--------
rs728391661,2
C,F--49058866(+) TGAACC/TTCTCT 1 -- us2k12Minor allele frequency- T:0.05WA NA 238

HapMap Linkage Disequilibrium report for DLX4 (48046334 - 48052323 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for DLX4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833474CNV Loss17160897
nsv908588CNV Loss21882294
nsv908589CNV Loss21882294
esv24299CNV Gain19812545

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DLX4
DNA2.0 Custom Variant and Variant Library Synthesis for DLX4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601911    OMIM disorders: --

Selected diseases for DLX4 (see all 23):    
About MalaCards
x-linked charcot-marie-tooth disease    dental enamel hypoplasia    adult acute lymphocytic leukemia    sickle cell disease
acute lymphocytic leukemia    choriocarcinoma    acute promyelocytic leukemia    tooth disease
charcot-marie-tooth disease    intrahepatic cholangiocarcinoma    cleft lip    cholangiocarcinoma
prostate adenocarcinoma    fibrosarcoma    herpes simplex    acute leukemia
lymphoblastic leukemia    breast cancer    leukemia    lung cancer


DLX4 for disorders           About GeneDecksing

9 Novoseek inferred disease relationships for DLX4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
charcot-marie-tooth disease 68.4 1 12542510 (1)
choriocarcinoma 51.9 4 15975650 (3), 9481790 (1)
sickle cell disease 29.2 2 11909945 (1)
cancer lung 11.8 16 16939914 (4)
leukemia 9.28 2 15975650 (1), 11707330 (1)
breast cancer 6.2 20 17626745 (10), 19119308 (4), 15248928 (4), 15975650 (1)
metastasis 0 4 17260014 (1), 15248928 (1)
tumors 0 3 15248928 (2), 15975650 (1)
cancer 0 5 16939914 (1)

Genetic Association Database (GAD): DLX4
Human Genome Epidemiology (HuGE) Navigator: DLX4 (2 documents)

Export disorders for DLX4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DLX4 gene, integrated from 10 sources (see all 66):
(articles sorted by number of sources associating them with DLX4)
    Utopia: connect your pdf to the dynamic
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  1. BP1, a homeodomain-containing isoform of DLX4, represses the beta- globin gene. (PubMed id 11909945)1, 2, 9 Chase M.B.... Berg P.E. (Mol. Cell. Biol. 2002)
  2. Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. (PubMed id 9073066)1, 2, 9 Quinn L.M.... Kalionis B. (Gene 1997)
  3. Genomic analysis of a new mammalian distal-less gene: Dlx7. (PubMed id 8975708)1, 2, 9 Nakamura S.... Ruddle F.H. (Genomics 1996)
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Genomic structure and functional control of the Dlx3-7 bigene cluster. (PubMed id 11792834)1, 2 Sumiyama K.... Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. BP1, a new homeobox gene, is frequently expressed in acute leukemias. (PubMed id 11069021)1, 2 Haga S.B.... Berg P.E. (Leukemia 2000)
  9. Identification of a mutation in DLX3 associated with tricho-dento- osseous (TDO) syndrome. (PubMed id 9467018)1, 2 Price J.A.... Hart T.C. (Hum. Mol. Genet. 1998)
  10. Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. (PubMed id 11707330)1, 9 Fu S....Berg P.E. (Gene 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1748 HGNC: 2917 AceView: DLX4 Ensembl:ENSG00000108813 euGenes: HUgn1748
ECgene: DLX4 H-InvDB: DLX4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DLX4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DLX4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DLX4 gene:
Search GeneIP for patents involving DLX4

GeneCards and IP:
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