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DLX2 Gene

protein-coding   GIFtS: 56
GCID: GC02M172964

Distal-Less Homeobox 2

(Previous name: distal-less homeo box 2)
  See DLX2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Distal-Less Homeobox 21 2
Distal-Less Homeo Box 21 2
TES12 5
TES-12
Homeobox Protein DLX-22

External Ids:    HGNC: 29151   Entrez Gene: 17462   Ensembl: ENSG000001158447   OMIM: 1262555   UniProtKB: Q076873   

Export aliases for DLX2 gene to outside databases

Previous GC identifers: GC02M171016 GC02M171625 GC02M172929 GC02M173166 GC02M172789 GC02M172672 GC02M164844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLX2 Gene:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with
Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of
Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx)
family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role
in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another
member of the gene family on the long arm of chromosome 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLX2 Gene:
DLX2 (distal-less homeobox 2) is a protein-coding gene. Diseases associated with DLX2 include dyslexia 2, and axenfeld-rieger syndrome. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BARX1.

UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687
Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
craniofacial patterning and morphogenesis

Gene Wiki entry for DLX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLX2 gene promoter:
         NF-1   MAZR   POU6F1 (c2)   Nkx2-5   Nkx5-1   Arnt   AREB6   IRF-2   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX2 promoter sequence
   Search Chromatin IP Primers for DLX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M172964:  view genomic region     (about GC identifiers)

Start:
172,964,166 bp from pter      End:
172,967,628 bp from pter
Size:
3,463 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687 (See protein sequence)
Recommended Name: Homeobox protein DLX-2  
Size: 328 amino acids; 34243 Da

Explore the universe of human proteins at neXtProt for DLX2: NX_Q07687

Explore proteomics data for DLX2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys173
  • Modification sites at PhosphoSitePlus

  • See DLX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004396.1  
    ENSEMBL proteins: 
     ENSP00000234198   ENSP00000446904  

    DLX2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DLX2

     
    Search eBioscience for Proteins for DLX2 

     
    antibodies-online proteins for DLX2 (5 products) 

     
    antibodies-online peptides for DLX2

    DLX2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DLX2
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    antibodies-online antibodies for DLX2 (51 products) 

    DLX2 Assay Products:

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    Cloud-Clone Corp. ELISAs for DLX2
    Cloud-Clone Corp. CLIAs for DLX2
    Search eBioscience for ELISAs for DLX2 
    antibodies-online kits for DLX2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    Selected InterPro protein domains (see all 6):
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR022135 Distal-less_N
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q07687

    ProtoNet protein and cluster: Q07687

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with DLX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLX2_HUMAN, Q07687
    Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
    craniofacial patterning and morphogenesis

         Genatlas biochemistry entry for DLX2:
    Drosophila distal less homolog Dlx2,homeo domain encoding gene,expressed in the forebrain,facial and limb
    primordia

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003727single-stranded RNA binding IEA--
         
    Find genes that share ontologies with DLX2           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dlx2):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  respiratory system  skeleton 

    Find genes that share phenotypes with DLX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DLX2: Dlx2tm1Jlr Dlx1/Dlx2Dlx1/tm2Jlr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DLX2:
    hsa-mir-331-3p (MIRT043264), hsa-mir-1296-5p (MIRT036105), hsa-mir-324-3p (MIRT042820)

    Block miRNA regulation of human, mouse, rat DLX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLX2 (see all 35):
    hsa-miR-194* hsa-miR-300 hsa-miR-199a-3p hsa-miR-507 hsa-miR-570 hsa-miR-124 hsa-miR-506 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidDLX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLX2
    Predesigned siRNA for gene silencing in human, mouse, rat DLX2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLX2

    Clone
    Products:
         
    OriGene clones in human, mouse for DLX2 (see all 5)
    OriGene ORF clones in mouse, rat for DLX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLX2 (NM_004405)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DLX2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DLX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLX2_HUMAN, Q07687: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with DLX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLX2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways


    1 BioSystems Pathway for DLX2
        SIDS Susceptibility Pathways


        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLX2: 
              Stem Cell Transcription Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DLX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for DLX2 (Q076873 ENSP000002341984) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOA2Q155963, ENSP000003999684I2D: score=3 STRING: ENSP00000399968
    MSX1P283603, ENSP000003721704I2D: score=2 STRING: ENSP00000372170
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    DIP2AQ146893, ENSP000003920664I2D: score=1 STRING: ENSP00000392066
    DLX5P561783, ENSP000002225984I2D: score=1 STRING: ENSP00000222598
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007420brain development TAS7590232
    GO:0009954proximal/distal pattern formation IEA--
    GO:0021544subpallium development IEA--

    Find genes that share ontologies with DLX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLX2 gene: 
    NM_004405.3  

    Unigene Cluster for DLX2:

    Distal-less homeobox 2
    Hs.419  [show with all ESTs]
    Unigene Representative Sequence: AB208823
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234198(uc002uhn.3) ENST00000466293(uc010zdx.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DLX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLX2 (see all 35):
    hsa-miR-194* hsa-miR-300 hsa-miR-199a-3p hsa-miR-507 hsa-miR-570 hsa-miR-124 hsa-miR-506 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidDLX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DLX2
    Predesigned siRNA for gene silencing in human, mouse, rat DLX2
    Clone
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    OriGene clones in human, mouse for DLX2 (see all 5)
    OriGene ORF clones in mouse, rat for DLX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLX2 (NM_004405)
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    Primer
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    OriGene qPCR primer pairs and template standards for DLX2
    OriGene qSTAR qPCR primer pairs in human, mouse for DLX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLX2
      QuantiTect SYBR Green Assays in human, mouse, rat DLX2
      QuantiFast Probe-based Assays in human, mouse, rat DLX2

    Additional mRNA sequence: 

    AB208823.1 AK291367.1 AK297503.1 AK316129.1 BC032558.1 L07919.1 

    4 DOTS entries:

    DT.306317  DT.91708454  DT.102822537  DT.91738161 

    18 AceView cDNA sequences:

    CR592469 NM_004405 BE798938 BM783560 BC032558 BE905163 BX460303 BX283905 
    BM474875 BX369487 BP365384 BF984868 L07919 BX341351 BI915940 BX442872 
    BM792757 BF034411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTAATGT
    DLX2 Expression
    About this image


    DLX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Telencephalon
     
     Tooth
             Ameloblasts Dental Enamel
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
    DLX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLX2: 
              Stem Cell Transcription Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DLX2
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    QuantiFast Probe-based Assays in human, mouse, rat DLX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLX2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlx21 , 5 distal-less homeobox 21, 5 88.58(n)1
    92.35(a)1
      2 (42.65 cM)5
    133921  NM_010054.21  NP_034184.11 
     715434095 
    lizard
    (Anolis carolinensis)
    Reptilia DLX26
    distal-less homeobox 2
    65(a)
    1 ↔ 1
    GL343353.1(369117-377088)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.7212 Xenopus laevis putative transcription factor DLL4 mRNA, more 77.66(n)    L09728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dlx2a2 distal-less homeobox gene 2a 82(n)   30574  NM_131311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dll6
    Distal-less
    27(a)
    1 → many
    2R(20702353-20722686)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-436
    Protein CEH-43 (ceh-43) mRNA, complete cds
    30(a)
    1 → many
    III(4446635-4449943) WBGene00000463


    ENSEMBL Gene Tree for DLX2 (if available)
    TreeFam Gene Tree for DLX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for DLX2 gene
    BARX12  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  MNX12  
    BARX22  DLX12  DLX32  LBX22  NKX1-22  BSX2  DLX52  DLX62  
    DLX42  LBX12  MSX22  MSX12  
    6 SIMAP similar genes for DLX2 using alignment to 3 protein entries:     DLX2_HUMAN (see all proteins):
    DLX6    NKX2-5    DLX5    DLX3    DLX1    POU6F1

    Find genes that share paralogs with DLX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLX2 (see all 94)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793656051,2
    --164844133(+) CGCCGC/GAGGGG 1 -- ds50010--------
    rs621838571,2
    C--164844182(+) AGTCAC/ACCCGC 1 -- ds50013Minor allele frequency- A:0.18NA 124
    rs621838581,2
    C,F--164844191(+) GCCGCC/GGGCCG 1 -- ds50013Minor allele frequency- G:0.21NA 124
    rs37913441,2
    C--164844454(+) TCTTCA/GTATTG 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs1885653761,2
    --164844549(+) GATAAA/GACAAA 1 -- ut310--------
    rs1131662821,2
    C--164844656(+) TGGGGG/TTTTAC 1 -- ut310--------
    rs1859194861,2
    --164844689(+) ATTTTA/TATACA 1 -- ut310--------
    rs1905171071,2
    --164844855(+) AGGTCA/TTCCGC 1 -- ut310--------
    rs1819974321,2
    --164844859(+) CATCCG/TCAAAG 1 -- ut310--------
    rs109305041,2
    C,F,H--164844889(+) AATAAA/CAAATA 1 -- ut3110Minor allele frequency- C:0.19NA WA CSA EA 254

    HapMap Linkage Disequilibrium report for DLX2 (172964166 - 172967628 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DLX2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLX2
    DNA2.0 Custom Variant and Variant Library Synthesis for DLX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126255    OMIM disorders: --

    3 diseases for DLX2:    
    About MalaCards
    dyslexia 2    axenfeld-rieger syndrome    ankylosis

    1 disease from the University of Copenhagen DISEASES database for DLX2:
    Ankylosis

    Find genes that share disorders with DLX2           About GenesLikeMe

    Genetic Association Database (GAD): DLX2
    Human Genome Epidemiology (HuGE) Navigator: DLX2 (20 documents)

    Export disorders for DLX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLX2 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with DLX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. (PubMed id 1354641)1, 3, 9 OzAselik T....Francke U. (Genomics 1992)
    2. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 9 Simeone A....Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. (PubMed id 7901126)1, 2, 9 Selski D.J.... Rogers K.E. (Gene 1993)
    4. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PubMed id 18728693)1, 4, 9 Liu X....Holden J.J. (Eur. J. Hum. Genet. 2009)
    5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders. (PubMed id 19018235)1, 4 Laroche F....Robel L. (Psychiatr. Genet. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus. (PubMed id 8812481)1, 2 McGuinness T.... Rubenstein J.L.R. (Genomics 1996)
    10. Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein. (PubMed id 15751970)1, 9 Espinoza H.M....Amendt B.A. (Biochemistry 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1746 HGNC: 2915 AceView: DLX2 Ensembl:ENSG00000115844 euGenes: HUgn1746
    ECgene: DLX2 H-InvDB: DLX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLX2 gene:
    Search GeneIP for patents involving DLX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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