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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DLX2 Gene

protein-coding GIFtS: 56
GCID: GC02M172964

distal-less homeobox 2

(Previous name: distal-less homeo box 2 )

Explore 17 diseases affiliated with
DLX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Distal-Less Homeobox 2¹ ²
TES-1¹ ²
Distal-Less Homeo Box 2¹ ²
TES1² ⁵
Homeobox Protein DLX-2²

External Ids:	HGNC: 2915¹	Entrez Gene: 1746²	Ensembl: ENSG00000115844⁷	OMIM: 126255⁵	UniProtKB: Q07687³

Export aliases for DLX2 gene to outside databases

Previous GC identifers: GC02M171016 GC02M171625 GC02M172929 GC02M173166 GC02M172789 GC02M172672 GC02M164844

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLX2:

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with

Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of

Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of

genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain

and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene

family on the long arm of chromosome 2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687

Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial

patterning and morphogenesis

Gene Wiki entry for DLX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DLX2 gene promoter:
NF-1 MAZR POU6F1 (c2) Nkx2-5 Nkx5-1 Arnt AREB6 IRF-2 NF-kappaB1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLX2 promoter sequence

Search SABiosciences Chromatin IP Primers for DLX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1

DLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M172964: view genomic region (about GC identifiers)

Start:	172,964,166 bp from pter	End:	172,967,628 bp from pter
Size:	3,463 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687 (See protein sequence)

Recommended Name: Homeobox protein DLX-2

Size: 328 amino acids; 34243 Da

Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for DLX2: NX_Q07687

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07687

DLX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004396.1

ENSEMBL proteins:

ENSP00000234198 ENSP00000446904

Human Recombinant Protein Products for DLX2:

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	Novus Biologicals DLX2 Proteins Novus Biologicals DLX2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DLX2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

DLX2 for ontologies About GeneDecksing

DLX2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DLX2
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	ThermoFisher Antibodies for DLX2

Assay Products for DLX2:

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	GenScript Custom Assay Services for DLX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DLX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DLX2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000047 HTH_motif

IPR022135 Distal-less_N

IPR017970 Homeobox_CS

IPR020479 Homeobox_metazoa

IPR001356 Homeodomain

Graphical View of Domain Structure for InterPro Entry Q07687

ProtoNet protein and cluster: Q07687

1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687

Similarity: Belongs to the distal-less homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DLX2_HUMAN, Q07687

Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial

patterning and morphogenesis

Genatlas biochemistry entry for DLX2:

Drosophila distal less homolog Dlx2,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	IEA	--
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003727	single-stranded RNA binding	IEA	--

DLX2 for ontologies About GeneDecksing

Phenotypes:
13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dlx2):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
growth/size	hearing/vestibular/ear	homeostasis/metabolism	mortality/aging	muscle
nervous system	respiratory system	skeleton

DLX2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for DLX2: Dlx2^tm1Jlr Dlx1/Dlx2^Dlx1/tm2Jlr

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DLX2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX2 (see all 35):
		hsa-miR-194* hsa-miR-300 hsa-miR-199a-3p hsa-miR-507 hsa-miR-570 hsa-miR-124 hsa-miR-506 hsa-miR-548am

		SwitchGear 3'UTR luciferase reporter plasmid: DLX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX2 (see all 4) OriGene shRNA RFP: DLX2 OriGene siRNA: DLX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DLX2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DLX2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLX2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DLX2 (NM_004405)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DLX2
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		Sirion Biotech Customized stable knockdown cell line services for DLX2 Sirion Biotech Customized inducible knockdown cell line services for DLX2 Sirion Biotech Customized stable overexpressing cell line services for DLX2 Sirion Biotech Customized inducible overexpressing cell line services for DLX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription factors in neurogenesis

Transcription factors in neurogenesis

1.00

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for DLX2

Transcription factors in neurogenesis

1 BioSystems Pathway for DLX2

SIDS Susceptibility Pathways

DLX2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DLX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for DLX2 (Q07687³ ENSP00000234198⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA2	Q15596³, ENSP00000399968⁴	I2D: score=3 STRING: ENSP00000399968
MSX1	P28360³, ENSP00000372170⁴	I2D: score=2 STRING: ENSP00000372170
DIP2A	Q14689³, ENSP00000392066⁴	I2D: score=1 STRING: ENSP00000392066
DLX5	P56178³, ENSP00000222598⁴	I2D: score=1 STRING: ENSP00000222598
XRCC6	P12956³, ENSP00000352257⁴	I2D: score=1 STRING: ENSP00000352257

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007420	brain development	TAS	7590232
GO:0009954	proximal/distal pattern formation	IEA	--
GO:0021766	hippocampus development	IEA	--

DLX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DLX2
Search CenterWatch for drugs/clinical trials and news about DLX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DLX2 gene:

NM_004405.3

Unigene Cluster for DLX2:

Distal-less homeobox 2

Hs.419 [show with all ESTs]

Unigene Representative Sequence: AB208823

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000234198(uc002uhn.3) ENST00000466293(uc010zdx.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX2 (see all 35):
		hsa-miR-194* hsa-miR-300 hsa-miR-199a-3p hsa-miR-507 hsa-miR-570 hsa-miR-124 hsa-miR-506 hsa-miR-548am

		SwitchGear 3'UTR luciferase reporter plasmid: DLX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX2 (see all 4) OriGene shRNA RFP: DLX2 OriGene siRNA: DLX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DLX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLX2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DLX2 (NM_004405)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLX2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX2

Additional cDNA sequence:

AB208823.1 AK291367.1 AK297503.1 AK316129.1 BC032558.1 L07919.1

4 DOTS entries:

DT.306317 DT.91708454 DT.102822537 DT.91738161

18 AceView cDNA sequences:

CR592469 NM_004405 BF984868 BX369487 BE798938 BX283905 L07919 BM783560

BX460303 BC032558 BP365384 BE905163 BM474875 BX341351 BI915940 BX442872

BM792757 BF034411

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DLX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTAATGT

About this image

DLX2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Selective marker (cell-identifying gene)

Blood Brain Barrier, Endothelium

Eye

Ganglion Cell Layer

Dopaminergic Amacrine Cells

Amacrine, Retina

Eye

Ganglion Cell Layer

Immature Ganglion Cells

Ganglion, Retina

Eye

Ganglion Cell Layer

Mature Ganglion Cells

Ganglion, Retina

Eye

Inner Nuclear Layer

Dopaminergic Amacrine Cells

Amacrine, Retina

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Head Mesenchyme

Branchial Arch 2

Cranial Neural Crest Cells

Neural Crest

Head Mesenchyme

Prechordal Mesenchyme

Diencephalic Neural Crest Cells

Neural Crest

Head Mesenchyme

Prechordal Mesenchyme

Mesencephalic Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DLX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLX2

SOURCE GeneReport for Unigene cluster: Hs.419

SABiosciences Expression via Pathway-Focused PCR Arrays including DLX2:

Stem Cell Transcription Factors in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Homeobox (HOX) Genes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLX2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DLX2 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	DLX2⁶	--	66(a)	1 ↔ 1	GL343353.1(369542-374786)
African clawed frog (Xenopus laevis)	Amphibia	Xl.721²	Xenopus laevis putative transcription factor DLL4 mRNA, more	77.66(n)		L09728.1
zebrafish (Danio rerio)	Actinopterygii	dlx2a²	distal-less homeobox gene 2a	82(n)		30574 NM_131311.1
fruit fly (Drosophila melanogaster)	Insecta	Dll¹	Distal-less	55.22(n) 52.36(a)		37973 NM_079133.1 NP_523857.1
worm (Caenorhabditis elegans)	Secernentea	ceh-43⁶	Homeobox protein ceh-43	21(a)	1 → many	III(4446606-4449912)

ENSEMBL Gene Tree for DLX2 (if available)
TreeFam Gene Tree for DLX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DLX2 gene

BARX1² BSX² DLX5² DLX6² BARHL2² BARHL1² DLX4² BARX2²

DLX1² MSX2² MSX1² DLX3²

6 SIMAP similar genes for DLX2 using alignment to 3 protein entries: DLX2_HUMAN (see all proteins):

NKX2-5 DLX3 DLX5 DLX6 DLX1 POU6F1

DLX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79365605^1,2		--	164844133(+)	`CGCCGC/GAGGGG`	1	--	ds500¹		0	--	--	--	--
rs62183857^1,2	C	--	164844182(+)	`AGTCAC/ACCCGC`	1	--	ds500¹		3		NA	124
rs62183858^1,2	C	--	164844191(+)	`GCCGCC/GGGCCG`	1	--	ds500¹		3		NA	124
rs113166282^1,2	C	--	164844656(+)	`TGGGGG/TTTTAC`	1	--	ut3¹		0	--	--	--	--
rs114602098^1,2	C	--	164846067(+)	`ACGGGC/AGGCGG`	1	--	int¹		1		WA	118
rs12616187^1,2	H	--	164846322(+)	`GCGCAA/GGCCTG`	1	--	int¹		0	--	--	--	--
rs12616215^1,2	C,F,H	--	164846401(+)	`TCTCAG/AGCCCG`	1	--	int¹		2		NA	4
rs4410254^1,2	H	--	164847165(+)	`CGTAGG/TAGGTG`	2	Y S	mis¹		4		NS EA	418
rs3762499^1,2	C,F	--	164847997(+)	`GGCCAA/GGGGGC`	1	--	us2k¹ tfbs³		6		NA WA EA	364
rs62183859^1,2	C	--	164849026(+)	`GTGCGA/GGGTTG`	1	--	us2k¹		3		NA	124

HapMap Linkage Disequilibrium report for DLX2 (172964166 - 172967628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DLX2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLX2

DNA2.0 Custom Variant and Variant Library Synthesis for DLX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DLX2 for disorders           About GeneDecksing

OMIM gene information: 126255    OMIM disorders: --

17 diseases for DLX2:    About MalaCards

axenfeld-rieger syndrome sex reversal mental retardation epilepsy autism spectrum disorder

tooth agenesis ectodermal dysplasia oligodontia acute lymphoblastic leukemia

ankylosis lymphoblastic leukemia syndactyly pharyngitis

leukemia astrocytoma breast cancer cerebritis

neuronitis

1 disease from the University of Copenhagen DISEASES database for DLX2:

Ankylosis

Human Genome Epidemiology (HuGE) Navigator: DLX2 (20 documents)

Export disorders for DLX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DLX2 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with DLX2)

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DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. (PubMed id 1354641)^{1, 3, 9} Ozcelik T....Francke U. (1992)
Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)^{1, 2, 9} Simeone A....Boncinelli E. (1994)
The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. (PubMed id 7901126)^{1, 2, 9} Selski D.J.... Rogers K.E. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus. (PubMed id 8812481)^{1, 2} McGuinness T.... Rubenstein J.L.R. (1996)
The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PubMed id 18728693)^{1, 9} Liu X....Holden J.J. (2008)
Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein. (PubMed id 15751970)^{1, 9} Espinoza H.M....Amendt B.A. (2005)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling. (PubMed id 21357706)¹ Starkova J....Drabkin H.A. (2011)
Homeobox gene Dlx-2 is implicated in metabolic stress -induced necrosis. (PubMed id 21917150)¹ Lee S.Y....Kang H.S. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1746	HGNC: 2915	AceView: DLX2	Ensembl:ENSG00000115844	euGenes: HUgn1746
ECgene: DLX2	H-InvDB: DLX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for DLX2	Pharmacogenomics, SNPs, Pathways

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distal-less homeobox 2

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distal-less homeobox 2

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