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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLX2 Gene

protein-coding   GIFtS: 55
GCID: GC02M172964

Distal-Less Homeobox 2

(Previous name: distal-less homeo box 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Distal-Less Homeobox 21 2
Distal-Less Homeo Box 21 2
TES12 5
TES-12
Homeobox Protein DLX-22

External Ids:    HGNC: 29151   Entrez Gene: 17462   Ensembl: ENSG000001158447   OMIM: 1262555   UniProtKB: Q076873   

Export aliases for DLX2 gene to outside databases

Previous GC identifers: GC02M171016 GC02M171625 GC02M172929 GC02M173166 GC02M172789 GC02M172672 GC02M164844


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLX2 Gene:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with
Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of
Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx)
family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role
in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another
member of the gene family on the long arm of chromosome 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLX2 Gene: 
DLX2 (distal-less homeobox 2) is a protein-coding gene. Diseases associated with DLX2 include axenfeld-rieger syndrome, and mental retardation epilepsy. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BARX1.

UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687
Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
craniofacial patterning and morphogenesis

Gene Wiki entry for DLX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLX2 gene promoter:
         NF-1   MAZR   POU6F1 (c2)   Nkx2-5   Nkx5-1   Arnt   AREB6   IRF-2   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M172964:  view genomic region     (about GC identifiers)

Start:
172,964,166 bp from pter      End:
172,967,628 bp from pter
Size:
3,463 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687 (See protein sequence)
Recommended Name: Homeobox protein DLX-2  
Size: 328 amino acids; 34243 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for DLX2: NX_Q07687

Explore proteomics data for DLX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07687

  • DLX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DLX2 Protein Expression
    REFSEQ proteins: NP_004396.1  
    ENSEMBL proteins: 
     ENSP00000234198   ENSP00000446904  

    Human Recombinant Protein Products for DLX2: 
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    OriGene Protein Over-expression Lysate for DLX2
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    OriGene Custom Protein Services for DLX2
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    Novus Biologicals DLX2 Proteins
    Novus Biologicals DLX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DLX2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DLX2 for ontologies           About GeneDecksing



    DLX2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DLX2 

    Assay Products for DLX2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DLX2 
    Cloud-Clone Corp. CLIAs for DLX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    5/6 InterPro protein domains (see all 6):
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR022135 Distal-less_N
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q07687

    ProtoNet protein and cluster: Q07687

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX2_HUMAN, Q07687
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    DLX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLX2_HUMAN, Q07687
    Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
    craniofacial patterning and morphogenesis

         Genatlas biochemistry entry for DLX2:
    Drosophila distal less homolog Dlx2,homeo domain encoding gene,expressed in the forebrain,facial and limb
    primordia

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003727single-stranded RNA binding IEA--
         
    DLX2 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dlx2):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  respiratory system  skeleton 

    DLX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DLX2: Dlx2tm1Jlr Dlx1/Dlx2Dlx1/tm2Jlr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DLX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DLX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX2 (see all 35):
    hsa-miR-194* hsa-miR-300 hsa-miR-199a-3p hsa-miR-507 hsa-miR-570 hsa-miR-124 hsa-miR-506 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidDLX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DLX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DLX2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DLX2 (see all 6)
    OriGene ORF clones in mouse, rat for DLX2
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    GenScript: all cDNA clones in your preferred vector: DLX2 (NM_004405)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX2
    Sirion Biotech Customized lentivirus for stable overexpression of DLX2 
                         Customized lentivirus expression plasmids for stable overexpression of DLX2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DLX2
    Search LifeMap BioReagents cell lines for DLX2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DLX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DLX2
        Transcription factors in neurogenesis


    1 BioSystems Pathway for DLX2
        SIDS Susceptibility Pathways



    DLX2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for DLX2 (Q076873 ENSP000002341984) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOA2Q155963, ENSP000003999684I2D: score=3 STRING: ENSP00000399968
    MSX1P283603, ENSP000003721704I2D: score=2 STRING: ENSP00000372170
    DIP2AQ146893, ENSP000003920664I2D: score=1 STRING: ENSP00000392066
    DLX5P561783, ENSP000002225984I2D: score=1 STRING: ENSP00000222598
    XRCC6P129563, ENSP000003522574I2D: score=1 STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007420brain development TAS7590232
    GO:0009954proximal/distal pattern formation IEA--
    GO:0021766hippocampus development IEA--

    DLX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLX2

    Search CenterWatch for drugs/clinical trials and news about DLX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DLX2 gene: 
    NM_004405.3  

    Unigene Cluster for DLX2:

    Distal-less homeobox 2
    Hs.419  [show with all ESTs]
    Unigene Representative Sequence: AB208823
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234198(uc002uhn.3) ENST00000466293(uc010zdx.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX2 (see all 35):
    hsa-miR-194* hsa-miR-300 hsa-miR-199a-3p hsa-miR-507 hsa-miR-570 hsa-miR-124 hsa-miR-506 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidDLX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DLX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX2
    Clone
    Products:
         
    OriGene clones in human, mouse for DLX2 (see all 6)
    OriGene ORF clones in mouse, rat for DLX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLX2 (NM_004405)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX2
    Sirion Biotech Customized lentivirus for stable overexpression of DLX2 
                         Customized lentivirus expression plasmids for stable overexpression of DLX2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DLX2
    OriGene qSTAR qPCR primer pairs in human, mouse for DLX2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DLX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX2

    Additional mRNA sequence: 

    AB208823.1 AK291367.1 AK297503.1 AK316129.1 BC032558.1 L07919.1 

    4 DOTS entries:

    DT.306317  DT.91708454  DT.102822537  DT.91738161 

    18 AceView cDNA sequences:

    CR592469 NM_004405 BX283905 BX460303 L07919 BE798938 BE905163 BX369487 
    BM474875 BP365384 BF984868 BM783560 BC032558 BX341351 BI915940 BX442872 
    BM792757 BF034411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLX2 expression in normal human tissues (normalized intensities)      DLX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTAATGT
    DLX2 Expression
    About this image


    DLX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 29 entries
             Endothelial Cells Blood Brain Barrier
             Globus Pallidus
             Substantia Nigra   
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Ameloblasts Dental Enamel
             mouse/organ system/integumental system   
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Dopaminergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Telencephalon
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 5 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme

    See DLX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLX2

    SOURCE GeneReport for Unigene cluster: Hs.419
        SABiosciences Expression via Pathway-Focused PCR Arrays including DLX2: 
              Stem Cell Transcription Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DLX2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlx21 , 5 distal-less homeobox 21, 5 90.01(n)1
    95.41(a)1
      2 (42.65 cM)5
    133921  NM_010054.21  NP_034184.11 
     715434095 
    chicken
    (Gallus gallus)
    Aves --
    --
    67(a)
    possible ortholog
    27(2998452-3005555)
    lizard
    (Anolis carolinensis)
    Reptilia DLX26
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343353.1(369117-377088)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.7212 Xenopus laevis putative transcription factor DLL4 mRNA, more 77.66(n)    L09728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dlx2a2 distal-less homeobox gene 2a 82(n)   30574  NM_131311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dll1 Distal-less 55.22(n)
    52.36(a)
      37973  NM_079133.1  NP_523857.1 


    ENSEMBL Gene Tree for DLX2 (if available)
    TreeFam Gene Tree for DLX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLX2 gene
    BARX12  NKX1-12  VENTX2  BARHL12  BARHL22  BARX22  DLX12  DLX32  
    LBX22  NKX1-22  BSX2  DLX52  DLX62  DLX42  LBX12  MSX22  
    MSX12  
    6 SIMAP similar genes for DLX2 using alignment to 3 protein entries:     DLX2_HUMAN (see all proteins):
    DLX6    NKX2-5    DLX3    DLX5    DLX1    POU6F1

    DLX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/94 SNPs in DLX2 are shown (see all 94)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793656051,2
    --164844133(+) CGCCGC/GAGGGG 1 -- ds50010--------
    rs621838571,2
    C--164844182(+) AGTCAC/ACCCGC 1 -- ds50013Minor allele frequency- A:0.18NA 124
    rs621838581,2
    C,F--164844191(+) GCCGCC/GGGCCG 1 -- ds50013Minor allele frequency- G:0.21NA 124
    rs37913441,2
    C--164844454(+) TCTTCA/GTATTG 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs1885653761,2
    --164844549(+) GATAAA/GACAAA 1 -- ut310--------
    rs1131662821,2
    C--164844656(+) TGGGGG/TTTTAC 1 -- ut310--------
    rs1859194861,2
    --164844689(+) ATTTTA/TATACA 1 -- ut310--------
    rs1905171071,2
    --164844855(+) AGGTCA/TTCCGC 1 -- ut310--------
    rs1819974321,2
    --164844859(+) CATCCG/TCAAAG 1 -- ut310--------
    rs109305041,2
    C,F,H--164844889(+) AATAAA/CAAATA 1 -- ut3110Minor allele frequency- C:0.19NA WA CSA EA 254

    HapMap Linkage Disequilibrium report for DLX2 (172964166 - 172967628 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DLX2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DLX2
    DNA2.0 Custom Variant and Variant Library Synthesis for DLX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 126255    OMIM disorders: --

    15 diseases for DLX2:    About MalaCards
    axenfeld-rieger syndrome    mental retardation epilepsy    ankylosis    tooth agenesis
    autism spectrum disorder    syndactyly    ectodermal dysplasia    acute lymphoblastic leukemia
    lymphoblastic leukemia    mental retardation    astrocytoma    cerebritis
    leukemia    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for DLX2:
    Ankylosis

    DLX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DLX2
    Human Genome Epidemiology (HuGE) Navigator: DLX2 (20 documents)

    Export disorders for DLX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLX2 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with DLX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. (PubMed id 1354641)1, 3, 9 Ozcelik T....Francke U. (1992)
    2. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 9 Simeone A....Boncinelli E. (1994)
    3. The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. (PubMed id 7901126)1, 2, 9 Selski D.J.... Rogers K.E. (1993)
    4. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PubMed id 18728693)1, 4, 9 Liu X....Holden J.J. (2008)
    5. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    7. Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders. (PubMed id 19018235)1, 4 Laroche F....Robel L. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus. (PubMed id 8812481)1, 2 McGuinness T.... Rubenstein J.L.R. (1996)
    10. Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein. (PubMed id 15751970)1, 9 Espinoza H.M....Amendt B.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1746 HGNC: 2915 AceView: DLX2 Ensembl:ENSG00000115844 euGenes: HUgn1746
    ECgene: DLX2 H-InvDB: DLX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DLX2 gene:
    Search GeneIP for patents involving DLX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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