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Aliases for DLX2 Gene

Aliases for DLX2 Gene

  • Distal-Less Homeobox 2 2 3
  • Distal-Less Homeo Box 2 2 3
  • TES1 3 6
  • Homeobox Protein DLX-2 3
  • TES-1 3

External Ids for DLX2 Gene

Previous GeneCards Identifiers for DLX2 Gene

  • GC02M171016
  • GC02M171625
  • GC02M172929
  • GC02M173166
  • GC02M172789
  • GC02M172672
  • GC02M164844
  • GC02M172964

Summaries for DLX2 Gene

Entrez Gene Summary for DLX2 Gene

  • Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLX2 Gene

DLX2 (Distal-Less Homeobox 2) is a Protein Coding gene. Diseases associated with DLX2 include dyslexia 2 and ankylosis. Among its related pathways are SIDS Susceptibility Pathways. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for DLX2 Gene

  • Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis

Gene Wiki entry for DLX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLX2 Gene

Genomics for DLX2 Gene

Regulatory Elements for DLX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DLX2 Gene

Start:
172,099,438 bp from pter
End:
172,102,900 bp from pter
Size:
3,463 bases
Orientation:
Minus strand

Genomic View for DLX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLX2 Gene

Proteins for DLX2 Gene

  • Protein details for DLX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07687-DLX2_HUMAN
    Recommended name:
    Homeobox protein DLX-2
    Protein Accession:
    Q07687
    Secondary Accessions:
    • B4DMK4
    • B7ZA14

    Protein attributes for DLX2 Gene

    Size:
    328 amino acids
    Molecular mass:
    34243 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLX2 Gene

Proteomics data for DLX2 Gene at MOPED

Post-translational modifications for DLX2 Gene

  • Ubiquitination at Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for DLX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DLX2 Gene

Domains for DLX2 Gene

Gene Families for DLX2 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Graphical View of Domain Structure for InterPro Entry

Q07687

UniProtKB/Swiss-Prot:

DLX2_HUMAN :
  • Q07687
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the distal-less homeobox family.
genes like me logo Genes that share domains with DLX2: view

Function for DLX2 Gene

Molecular function for DLX2 Gene

GENATLAS Biochemistry:
Drosophila distal less homolog Dlx2,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia
UniProtKB/Swiss-Prot Function:
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis

Gene Ontology (GO) - Molecular Function for DLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1354641
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DLX2: view
genes like me logo Genes that share phenotypes with DLX2: view

Animal Models for DLX2 Gene

MGI Knock Outs for DLX2:

Animal Model Products

miRNA for DLX2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLX2 Gene

Localization for DLX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLX2 Gene COMPARTMENTS Subcellular localization image for DLX2 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for DLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DLX2: view

Pathways for DLX2 Gene

SuperPathways for DLX2 Gene

genes like me logo Genes that share pathways with DLX2: view

Pathways by source for DLX2 Gene

1 BioSystems pathway for DLX2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0007420 brain development TAS 7590232
GO:0009954 proximal/distal pattern formation IEA --
GO:0021544 subpallium development IEA --
genes like me logo Genes that share ontologies with DLX2: view

Transcripts for DLX2 Gene

mRNA/cDNA for DLX2 Gene

(18) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DLX2 Gene

Distal-less homeobox 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLX2 Gene

No ASD Table

Relevant External Links for DLX2 Gene

GeneLoc Exon Structure for
DLX2
ECgene alternative splicing isoforms for
DLX2

Expression for DLX2 Gene

mRNA expression in normal human tissues for DLX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLX2 Gene

This gene is overexpressed in Brain - Hypothalamus (7.6), Brain - Anterior cingulate cortex (BA24) (4.7), and Brain - Cortex (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DLX2 Gene

SOURCE GeneReport for Unigene cluster for DLX2 Gene Hs.419

genes like me logo Genes that share expressions with DLX2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DLX2 Gene

Orthologs for DLX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLX2 35
  • 89.47 (n)
  • 93.56 (a)
DLX2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLX2 35
  • 90.08 (n)
  • 93.25 (a)
DLX2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlx2 35
  • 88.58 (n)
  • 92.35 (a)
Dlx2 16
Dlx2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLX2 35
  • 98.17 (n)
  • 97.56 (a)
DLX2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlx2 35
  • 88.38 (n)
  • 92.05 (a)
oppossum
(Monodelphis domestica)
Mammalia DLX2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLX2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLX2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlx2 35
  • 70.18 (n)
  • 72.63 (a)
Str.9796 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.721 35
zebrafish
(Danio rerio)
Actinopterygii dlx2a 35
  • 68.52 (n)
  • 69.26 (a)
dlx2a 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3918 35
fruit fly
(Drosophila melanogaster)
Insecta Dll 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-43 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
CSA.6494 36
  • 14 (a)
ManyToMany
Species with no ortholog for DLX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLX2 Gene

ENSEMBL:
Gene Tree for DLX2 (if available)
TreeFam:
Gene Tree for DLX2 (if available)

Paralogs for DLX2 Gene

Selected SIMAP similar genes for DLX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DLX2: view

Variants for DLX2 Gene

Sequence variations from dbSNP and Humsavar for DLX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs743605 -- 172,102,574(-) CGCAC(A/G)CCCGC utr-variant-5-prime
rs2228184 -- 172,101,522(-) ACTCA(A/G)TACTT reference, synonymous-codon
rs3762499 -- 172,103,018(+) GGCCA(A/G)GGGGC upstream-variant-2KB
rs3791344 -- 172,099,475(+) TCTTC(A/G)TATTG utr-variant-3-prime
rs3834781 -- 172,103,583(+) CGAGA(-/CT)CTGAG upstream-variant-2KB

Relevant External Links for DLX2 Gene

HapMap Linkage Disequilibrium report
DLX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DLX2 Gene

Disorders for DLX2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DLX2 Gene in MalaCards »

(2) Diseases for DLX2 Gene including...

(1) University of Copenhagen DISEASES for DLX2 Gene

Relevant External Links for DLX2

Genetic Association Database (GAD)
DLX2
Human Genome Epidemiology (HuGE) Navigator
DLX2
genes like me logo Genes that share disorders with DLX2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for DLX2 Gene

Publications for DLX2 Gene

  1. The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. (PMID: 7901126) Selski D.J. … Rogers K.E. (Gene 1993) 3 4 23
  2. Cloning and characterization of two members of the vertebrate Dlx gene family. (PMID: 7907794) Simeone A. … Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  3. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PMID: 18728693) Liu X. … Holden J.J. (Eur. J. Hum. Genet. 2009) 3 23 48
  4. DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. (PMID: 1354641) OzAselik T. … Francke U. (Genomics 1992) 2 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DLX2 Gene

  • Addgene plasmids for DLX2

Sources for DLX2 Gene

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