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Aliases for DLX1 Gene

Aliases for DLX1 Gene

  • Distal-Less Homeobox 1 2 3
  • Distal-Less Homeo Box 1 2

External Ids for DLX1 Gene

Previous GeneCards Identifiers for DLX1 Gene

  • GC02P171002
  • GC02P171610
  • GC02P172913
  • GC02P173152
  • GC02P172775
  • GC02P172657
  • GC02P164830
  • GC02P172949

Summaries for DLX1 Gene

Entrez Gene Summary for DLX1 Gene

  • This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLX1 Gene

DLX1 (Distal-Less Homeobox 1) is a Protein Coding gene. Diseases associated with DLX1 include autism spectrum disorder. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Packaging Of Telomere Ends. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for DLX1 Gene

  • Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLX1 Gene

Genomics for DLX1 Gene

Regulatory Elements for DLX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DLX1 Gene

Start:
172,084,740 bp from pter
End:
172,089,677 bp from pter
Size:
4,938 bases
Orientation:
Plus strand

Genomic View for DLX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLX1 Gene

Proteins for DLX1 Gene

  • Protein details for DLX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56177-DLX1_HUMAN
    Recommended name:
    Homeobox protein DLX-1
    Protein Accession:
    P56177
    Secondary Accessions:
    • D3DPD7
    • Q53ZU4
    • Q7Z724
    • Q8IYB2

    Protein attributes for DLX1 Gene

    Size:
    255 amino acids
    Molecular mass:
    27320 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLX1 Gene

Proteomics data for DLX1 Gene at MOPED

Post-translational modifications for DLX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLX1 Gene

Antibody Products

No data available for DME Specific Peptides for DLX1 Gene

Domains for DLX1 Gene

Gene Families for DLX1 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Suggested Antigen Peptide Sequences for DLX1 Gene

Graphical View of Domain Structure for InterPro Entry

P56177

UniProtKB/Swiss-Prot:

DLX1_HUMAN :
  • P56177
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the distal-less homeobox family.
genes like me logo Genes that share domains with DLX1: view

Function for DLX1 Gene

Molecular function for DLX1 Gene

GENATLAS Biochemistry:
Drosophila distal less homolog Dlx1,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia
UniProtKB/Swiss-Prot Function:
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).

Gene Ontology (GO) - Molecular Function for DLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DLX1: view
genes like me logo Genes that share phenotypes with DLX1: view

Animal Models for DLX1 Gene

MGI Knock Outs for DLX1:

Animal Model Products

miRNA for DLX1 Gene

miRTarBase miRNAs that target DLX1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLX1 Gene

Localization for DLX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLX1 Gene COMPARTMENTS Subcellular localization image for DLX1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DLX1: view

Pathways for DLX1 Gene

genes like me logo Genes that share pathways with DLX1: view

Pathways by source for DLX1 Gene

1 BioSystems pathway for DLX1 Gene
1 GeneGo (Thomson Reuters) pathway for DLX1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0009954 proximal/distal pattern formation IEA --
GO:0021544 subpallium development IEA --
GO:0021766 hippocampus development IEA --
genes like me logo Genes that share ontologies with DLX1: view

Transcripts for DLX1 Gene

Unigene Clusters for DLX1 Gene

Distal-less homeobox 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLX1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for DLX1 Gene

GeneLoc Exon Structure for
DLX1
ECgene alternative splicing isoforms for
DLX1

Expression for DLX1 Gene

mRNA expression in normal human tissues for DLX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLX1 Gene

This gene is overexpressed in Brain - Hypothalamus (11.0), Brain - Anterior cingulate cortex (BA24) (7.5), Brain - Frontal Cortex (BA9) (5.4), Brain - Amygdala (5.2), Brain - Cortex (5.2), and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DLX1 Gene

SOURCE GeneReport for Unigene cluster for DLX1 Gene Hs.407015

genes like me logo Genes that share expressions with DLX1: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DLX1 Gene

Orthologs for DLX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLX1 35
  • 95.42 (n)
  • 98.82 (a)
DLX1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLX1 35
  • 94.9 (n)
  • 99.61 (a)
DLX1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlx1 35
  • 92.03 (n)
  • 98.82 (a)
Dlx1 16
Dlx1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLX1 35
  • 99.87 (n)
  • 100 (a)
DLX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlx1 35
  • 92.16 (n)
  • 98.82 (a)
oppossum
(Monodelphis domestica)
Mammalia DLX1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLX1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLX1 35
  • 85.1 (n)
  • 89.41 (a)
DLX1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLX1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlx1 35
  • 79.42 (n)
  • 86.45 (a)
zebrafish
(Danio rerio)
Actinopterygii dlx1a 35
  • 74.87 (n)
  • 78.57 (a)
dlx1a 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dll 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-43 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
Species with no ortholog for DLX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLX1 Gene

ENSEMBL:
Gene Tree for DLX1 (if available)
TreeFam:
Gene Tree for DLX1 (if available)

Paralogs for DLX1 Gene

Selected SIMAP similar genes for DLX1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLX1: view

Variants for DLX1 Gene

Sequence variations from dbSNP and Humsavar for DLX1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs705868 -- 172,087,804(+) GCGGG(A/C)GGTTC intron-variant
rs788172 -- 172,088,710(+) TCTGC(A/G)GCCTC utr-variant-3-prime
rs788173 -- 172,088,732(+) ACAAG(A/G)TCTGA utr-variant-3-prime
rs788174 -- 172,089,249(+) TAATT(C/T)CAGTG utr-variant-3-prime
rs796840 -- 172,089,713(+) AGGGG(G/T)CCAGG downstream-variant-500B

Relevant External Links for DLX1 Gene

HapMap Linkage Disequilibrium report
DLX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DLX1 Gene

Disorders for DLX1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DLX1 Gene in MalaCards »

(1) Diseases for DLX1 Gene including...

(2) University of Copenhagen DISEASES for DLX1 Gene

Relevant External Links for DLX1

Genetic Association Database (GAD)
DLX1
Human Genome Epidemiology (HuGE) Navigator
DLX1
genes like me logo Genes that share disorders with DLX1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for DLX1 Gene

Publications for DLX1 Gene

  1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PMID: 7907794) Simeone A. … Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PMID: 18384059) KAohler A.K. … Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  3. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PMID: 18728693) Liu X. … Holden J.J. (Eur. J. Hum. Genet. 2009) 3 48
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 48
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48

Products for DLX1 Gene

  • Addgene plasmids for DLX1

Sources for DLX1 Gene

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