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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLX1 Gene

protein-coding   GIFtS: 57
GCID: GC02P172949

Distal-Less Homeobox 1

(Previous name: distal-less homeo box 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Distal-Less Homeobox 11 2
Distal-Less Homeo Box 11 2
Homeobox Protein DLX-12

External Ids:    HGNC: 29141   Entrez Gene: 17452   Ensembl: ENSG000001443557   OMIM: 6000295   UniProtKB: P561773   

Export aliases for DLX1 gene to outside databases

Previous GC identifers: GC02P171002 GC02P171610 GC02P172913 GC02P173152 GC02P172775 GC02P172657 GC02P164830


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLX1 Gene:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less
gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of
signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of
craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is
located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for DLX1 Gene: 
DLX1 (distal-less homeobox 1) is a protein-coding gene. Diseases associated with DLX1 include autism spectrum disorder, and syndactyly, and among its related super-pathways are Histone modification. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic
subdivisions (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLX1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CREB   IRF-2   E2F-1   E2F   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172949:  view genomic region     (about GC identifiers)

Start:
172,949,468 bp from pter      End:
172,954,405 bp from pter
Size:
4,938 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177 (See protein sequence)
Recommended Name: Homeobox protein DLX-1  
Size: 255 amino acids; 27320 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DPD7 Q53ZU4 Q7Z724 Q8IYB2
Alternative splicing: 2 isoforms:  P56177-1   P56177-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLX1: NX_P56177

Explore proteomics data for DLX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56177

  • DLX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DLX1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001033582.1  NP_835221.2  

    ENSEMBL proteins: 
     ENSP00000354865   ENSP00000448827   ENSP00000354478   ENSP00000341786  

    Human Recombinant Protein Products for DLX1: 
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    Novus Biologicals DLX1 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DLX1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    DLX1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DLX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P56177

    ProtoNet protein and cluster: P56177

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    DLX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLX1_HUMAN, P56177
    Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
    craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic
    subdivisions (By similarity)

         Genatlas biochemistry entry for DLX1:
    Drosophila distal less homolog Dlx1,homeo domain encoding gene,expressed in the forebrain,facial and limb
    primordia

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding NAS--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    DLX1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dlx1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  growth/size 
     hearing/vestibular/ear  mortality/aging  nervous system  no phenotypic analysis  skeleton 

    DLX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DLX1: Dlx1/Dlx2Dlx1/tm2Jlr Dlx1tm1Jlr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DLX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DLX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX1 

    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX1 (see all 40):
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    SwitchGear 3'UTR luciferase reporter plasmidDLX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DLX1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    2Regulation of nuclear SMAD2/3 signaling
    Regulation of nuclear SMAD2/3 signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DLX1
        Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for DLX1
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for DLX1
        Regulation of nuclear SMAD2/3 signaling



    DLX1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/11 Interacting proteins for DLX1 (P561773 ENSP000003544784) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
    ALX4Q9H1613I2D: score=1 
    BARX1Q9HBU13I2D: score=1 
    CDX1P479023I2D: score=1 
    CDX4O146273I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development NAS--
    GO:0009954proximal/distal pattern formation IEA--
    GO:0021766hippocampus development IEA--

    DLX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLX1

    Search CenterWatch for drugs/clinical trials and news about DLX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DLX1 gene (2 alternative transcripts): 
    NM_001038493.1  NM_178120.4  

    Unigene Cluster for DLX1:

    Distal-less homeobox 1
    Hs.407015  [show with all ESTs]
    Unigene Representative Sequence: NM_178120
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361609 ENST00000469444 ENST00000361725(uc002uhl.3 uc002uhm.3)
    ENST00000341900 ENST00000409492(uc010fqj.1) ENST00000475989 ENST00000550686

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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX1 (see all 40):
    hsa-miR-100* hsa-let-7a-2* hsa-miR-371-5p hsa-miR-1276 hsa-miR-489 hsa-miR-23a hsa-miR-330-3p hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidDLX1 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX1

    Additional mRNA sequence: 

    AK290503.1 AK308842.1 AY257976.1 BC013010.2 BC036189.1 BC053351.1 

    5 DOTS entries:

    DT.97836125  DT.423086  DT.91968339  DT.95363390  DT.91965258 

    24/38 AceView cDNA sequences (see all 38):

    CR624708 BX281379 AY257976 CR600227 BM016366 BI914883 BQ068101 BC053351 
    BI916759 BI822036 BI822794 BX441371 AK095266 BC013010 BI913703 BG491667 
    BI667479 BG107681 CA423738 BE739423 BM561358 AL537217 BM559101 BC036189 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DLX1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
    SP1:        -     -           -           -                                 
    SP2:                          -           -                                 
    SP3:                          -     -     -                                 
    SP4:                                      -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for DLX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLX1 expression in normal human tissues (normalized intensities)      DLX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGTGAAA
    DLX1 Expression
    About this image


    DLX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Thalamus
             Fetal Neuronal Stem Cells (NSC)   
             Septum   
     
     Tooth
             Dental Papilla Cells Dental Papilla
             Dental pulp Stem Cells (DPSC)   
             visceral organ/oral region/upper jaw   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Telencephalon
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 5 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
             PureStem 4D20.8, NCr-fac Progenitor
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             sensory organ/nose/naso-lacrimal duct   

    See DLX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLX1

    SOURCE GeneReport for Unigene cluster: Hs.407015
        SABiosciences Expression via Pathway-Focused PCR Arrays including DLX1: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DLX1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlx11 , 5 distal-less homeobox 11, 5 92.03(n)1
    98.82(a)1
      2 (42.61 cM)5
    133901  NM_010053.11  NP_034183.11 
     715281135 
    chicken
    (Gallus gallus)
    Aves DLX11 distal-less homeobox 1 85.1(n)
    89.41(a)
      429283  NM_001045842.2  NP_001039307.2 
    lizard
    (Anolis carolinensis)
    Reptilia DLX16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343353.1(411831-416517)
    zebrafish
    (Danio rerio)
    Actinopterygii dlx1a2 distal-less homeobox gene 1a 78.78(n)   30568  NM_131305.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-436
    Homeobox protein ceh-43
    25(a)
    1 → many
    III(4446635-4449943)


    ENSEMBL Gene Tree for DLX1 (if available)
    TreeFam Gene Tree for DLX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLX1 gene
    DLX22  BARX12  NKX1-12  VENTX2  BARHL12  BARHL22  BARX22  DLX32  
    LBX22  NKX1-22  BSX2  DLX52  DLX62  DLX42  LBX12  MSX22  
    MSX12  
    14 SIMAP similar genes for DLX1 using alignment to 5 protein entries:     DLX1_HUMAN (see all proteins):
    DLX6    MSX1    HMX2    NKX2-5    DLX3    HLX
    NKX1-2    BARX1    DLX2    DLX5    HOXA4    HOXB1
    BARX2    DLX4

    DLX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 SNPs in DLX1 are shown (see all 116)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848559431,2
    --172342718(+) CGTGTA/GGTTCG 2 -- us2k10--------
    rs1433108291,2
    --172342720(+) TGTGGC/TTCGGT 2 -- us2k10--------
    rs1474674591,2
    --172342824(+) ACCACG/TCTGCC 2 -- us2k10--------
    rs1398546221,2
    --172342997(+) TGTTCC/TCTCTG 2 -- us2k10--------
    rs1138353941,2
    C,F--172343138(+) TTGCTC/ATTAGT 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs751702941,2
    C--172343167(+) TATGCA/GTATGA 2 -- us2k10--------
    rs1452617371,2
    --172343191(+) GTGTTA/GTGCTA 2 -- us2k10--------
    rs1930139041,2
    C--172343201(+) AATGGC/GGCGCC 2 -- us2k10--------
    rs1852026791,2
    --172343203(+) TGGGGA/CGCCTT 2 -- us2k10--------
    rs1152469801,2
    C,F--172343385(+) TCACCG/ATGGGG 2 -- us2k12Minor allele frequency- A:0.02WA NA 238

    HapMap Linkage Disequilibrium report for DLX1 (172949468 - 172954405 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DLX1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DLX1
    DNA2.0 Custom Variant and Variant Library Synthesis for DLX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600029    OMIM disorders: --

    5 diseases for DLX1:    About MalaCards
    autism spectrum disorder    syndactyly    schizophrenia    neuronitis
    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for DLX1:
    Syndactyly     Autistic disorder

    DLX1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DLX1
    Human Genome Epidemiology (HuGE) Navigator: DLX1 (8 documents)

    Export disorders for DLX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLX1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with DLX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 3, 9 Simeone A....Boncinelli E. (1994)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    5. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PubMed id 18728693)1, 4 Liu X....Holden J.J. (2008)
    6. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 Kahler A.K....Andreassen O.A. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. (PubMed id 14671321)1, 2 Chiba S.... Hirai H. (2003)
    9. Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. (PubMed id 23312518)1 McKinsey G.L....Rubenstein J.L. (2013)
    10. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1745 HGNC: 2914 AceView: DLX1 Ensembl:ENSG00000144355 euGenes: HUgn1745
    ECgene: DLX1 H-InvDB: DLX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DLX1 gene:
    Search GeneIP for patents involving DLX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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