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Aliases for DLX1 Gene

Aliases for DLX1 Gene

  • Distal-Less Homeobox 1 2 3 5
  • Distal-Less Homeo Box 1 2

External Ids for DLX1 Gene

Previous GeneCards Identifiers for DLX1 Gene

  • GC02P171002
  • GC02P171610
  • GC02P172913
  • GC02P173152
  • GC02P172775
  • GC02P172657
  • GC02P164830
  • GC02P172949

Summaries for DLX1 Gene

Entrez Gene Summary for DLX1 Gene

  • This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLX1 Gene

DLX1 (Distal-Less Homeobox 1) is a Protein Coding gene. Diseases associated with DLX1 include Autism Spectrum Disorder. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and DNA Damage/Telomere Stress Induced Senescence. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is DLX6.

UniProtKB/Swiss-Prot for DLX1 Gene

  • Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLX1 Gene

Genomics for DLX1 Gene

Regulatory Elements for DLX1 Gene

Enhancers for DLX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F172092 2.7 VISTA FANTOM5 Ensembl ENCODE 7.9 +13.4 13441 10.5 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DAP3P2 DCAF17 DLX2 HAT1 ITGA6 ENSG00000232788 DLX1 DYNC1I2 GC02P172093
GH02F172083 1.4 VISTA Ensembl ENCODE 0.8 +0.8 769 5.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 HAT1 DLX1 GC02P172093
GH02F172091 2.1 VISTA 0.4 +7.0 6998 1.2 CBX8 RNF2 SUZ12 CBX2 EZH2 GC02P172093 DLX1
GH02F172090 0.2 ENCODE 0.4 +5.4 5408 0.2 RNF2 SUZ12 CBX2 FOXP2 EZH2 GC02P172093 DLX1
GH02F172093 0.5 ENCODE 0.4 +5.8 5828 0.2 SUZ12 RNF2 CBX2 GC02P172093 DLX1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DLX1 on UCSC Golden Path with GeneCards custom track

Promoters for DLX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000305261 660 1601 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9

Genomic Location for DLX1 Gene

Chromosome:
2
Start:
172,084,740 bp from pter
End:
172,089,677 bp from pter
Size:
4,938 bases
Orientation:
Plus strand

Genomic View for DLX1 Gene

Genes around DLX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLX1 Gene

Proteins for DLX1 Gene

  • Protein details for DLX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56177-DLX1_HUMAN
    Recommended name:
    Homeobox protein DLX-1
    Protein Accession:
    P56177
    Secondary Accessions:
    • D3DPD7
    • Q53ZU4
    • Q7Z724
    • Q8IYB2

    Protein attributes for DLX1 Gene

    Size:
    255 amino acids
    Molecular mass:
    27320 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLX1 Gene

Post-translational modifications for DLX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLX1 Gene

Antibody Products

  • Abcam antibodies for DLX1
  • Santa Cruz Biotechnology (SCBT) Antibodies for DLX1

No data available for DME Specific Peptides for DLX1 Gene

Domains & Families for DLX1 Gene

Gene Families for DLX1 Gene

Suggested Antigen Peptide Sequences for DLX1 Gene

Graphical View of Domain Structure for InterPro Entry

P56177

UniProtKB/Swiss-Prot:

DLX1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the distal-less homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the distal-less homeobox family.
genes like me logo Genes that share domains with DLX1: view

Function for DLX1 Gene

Molecular function for DLX1 Gene

GENATLAS Biochemistry:
Drosophila distal less homolog Dlx1,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia
UniProtKB/Swiss-Prot Function:
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).

Gene Ontology (GO) - Molecular Function for DLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DLX1: view
genes like me logo Genes that share phenotypes with DLX1: view

Animal Models for DLX1 Gene

MGI Knock Outs for DLX1:

Animal Model Products

miRNA for DLX1 Gene

miRTarBase miRNAs that target DLX1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DLX1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLX1 Gene

Localization for DLX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLX1 Gene COMPARTMENTS Subcellular localization image for DLX1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DLX1: view

Pathways & Interactions for DLX1 Gene

genes like me logo Genes that share pathways with DLX1: view

Pathways by source for DLX1 Gene

1 BioSystems pathway for DLX1 Gene
1 GeneGo (Thomson Reuters) pathway for DLX1 Gene

Gene Ontology (GO) - Biological Process for DLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
GO:0009954 proximal/distal pattern formation IEA --
genes like me logo Genes that share ontologies with DLX1: view

No data available for SIGNOR curated interactions for DLX1 Gene

Transcripts for DLX1 Gene

Unigene Clusters for DLX1 Gene

Distal-less homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DLX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for DLX1 Gene

GeneLoc Exon Structure for
DLX1
ECgene alternative splicing isoforms for
DLX1

Expression for DLX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DLX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLX1 Gene

This gene is overexpressed in Brain - Hypothalamus (x11.0), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Frontal Cortex (BA9) (x5.4), Brain - Amygdala (x5.2), Brain - Cortex (x5.2), and Brain - Hippocampus (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DLX1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DLX1 Gene:

DLX1

SOURCE GeneReport for Unigene cluster for DLX1 Gene:

Hs.407015
genes like me logo Genes that share expression patterns with DLX1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DLX1 Gene

Orthologs for DLX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLX1 34 35
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia DLX1 34 35
  • 95.42 (n)
dog
(Canis familiaris)
Mammalia DLX1 34 35
  • 94.9 (n)
rat
(Rattus norvegicus)
Mammalia Dlx1 34
  • 92.16 (n)
mouse
(Mus musculus)
Mammalia Dlx1 34 16 35
  • 92.03 (n)
oppossum
(Monodelphis domestica)
Mammalia DLX1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLX1 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLX1 34 35
  • 85.1 (n)
lizard
(Anolis carolinensis)
Reptilia DLX1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlx1 34
  • 79.42 (n)
zebrafish
(Danio rerio)
Actinopterygii dlx1a 34 35
  • 74.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dll 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-43 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
ManyToMany
Species where no ortholog for DLX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLX1 Gene

ENSEMBL:
Gene Tree for DLX1 (if available)
TreeFam:
Gene Tree for DLX1 (if available)

Paralogs for DLX1 Gene

Paralogs for DLX1 Gene

(13) SIMAP similar genes for DLX1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLX1: view

Variants for DLX1 Gene

Sequence variations from dbSNP and Humsavar for DLX1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111923266 -- 172,086,410(+) CCTGC(A/G)AAAAT intron-variant
rs112033071 -- 172,087,978(+) CCTGA(A/G)TCACG intron-variant
rs112920120 -- 172,085,861(+) CCTCG(C/T)CCTTC reference, missense
rs112984751 -- 172,087,832(+) CTCTT(A/T)TGGGG intron-variant
rs113178596 -- 172,083,717(+) AAGAG(A/G)AACCC upstream-variant-2KB

Variation tolerance for DLX1 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DLX1 Gene

Disorders for DLX1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DLX1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search DLX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLX1

Genetic Association Database (GAD)
DLX1
Human Genome Epidemiology (HuGE) Navigator
DLX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLX1
genes like me logo Genes that share disorders with DLX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLX1 Gene

Publications for DLX1 Gene

  1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PMID: 7907794) Simeone A. … Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 22 64
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  3. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PMID: 18728693) Liu X. … Holden J.J. (Eur. J. Hum. Genet. 2009) 3 46 64
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 46 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for DLX1 Gene

Sources for DLX1 Gene

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