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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLX1 Gene

protein-coding   GIFtS: 54
GCID: GC02P172949

distal-less homeobox 1

(Previous name: distal-less homeo box 1 )
 Explore 6 diseases affiliated with
DLX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DLX1    

Aliases
for DLX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Distal-Less Homeobox 11 2
Distal-Less Homeo Box 11 2
Homeobox Protein DLX-12

External Ids:    HGNC: 29141   Entrez Gene: 17452   Ensembl: ENSG000001443557   OMIM: 6000295   UniProtKB: P561773   

Export aliases for DLX1 gene to outside databases

Previous GC identifers: GC02P171002 GC02P171610 GC02P172913 GC02P173152 GC02P172775 GC02P172657 GC02P164830


Summaries
for DLX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DLX1:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene.
The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from
multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning
and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail
configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript
variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial
patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity)




Genomic Views
for DLX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLX1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CREB   IRF-2   E2F-1   E2F   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172949:  view genomic region     (about GC identifiers)

Start:
 172,949,468 bp from pter      End:
 172,954,405 bp from pter
Size:
 4,938 bases      Orientation:
 plus strand

Proteins
for DLX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177 (See protein sequence)
Recommended Name: Homeobox protein DLX-1  
Size: 255 amino acids; 27320 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DPD7 Q53ZU4 Q7Z724 Q8IYB2
Alternative splicing: 2 isoforms:  P56177-1   P56177-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLX1: NX_P56177

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56177

    • DLX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001033582.1  NP_835221.2  

    ENSEMBL proteins: 
     ENSP00000354865   ENSP00000448827   ENSP00000354478   ENSP00000341786   ENSP00000447772  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): DLX1
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    Novus Biologicals DLX1 Protein
    Novus Biologicals DLX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DLX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    DLX1 for ontologies           About GeneDecksing



    DLX1 Antibody Products: 
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    Uscn ELISAs and CLIAs for DLX1

    Protein Domains /
    Families
    for DLX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DLX1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P56177

    ProtoNet protein and cluster: P56177

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
    Similarity: Belongs to the distal-less homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for DLX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
    Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial
    patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity)

         Genatlas biochemistry entry for DLX1:
    Drosophila distal less homolog Dlx1,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia

    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX1 (see all 40):
    hsa-miR-100* hsa-let-7a-2* hsa-miR-371-5p hsa-miR-1276 hsa-miR-489 hsa-miR-23a hsa-miR-330-3p hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmid: DLX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX1 (see all 7)
    OriGene shRNA RFP: DLX1
    OriGene siRNA: DLX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DLX1 (NM_178120)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX1 

    Cell Line
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    Search LifeMap BioReagents cell lines for DLX1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding NAS--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----


    DLX1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for DLX1: Dlx1/Dlx2Dlx1/tm2Jlr Dlx1tm1Jlr
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dlx1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  growth/size 
     hearing/vestibular/ear  mortality/aging  nervous system  no phenotypic analysis  skeleton 

    DLX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DLX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Signal transduction_Activin A signaling regulation0.96
    2Regulation of nuclear SMAD2/3 signaling
    		Regulation of nuclear SMAD2/3 signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for DLX1
        Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for DLX1
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for DLX1 
        Regulation of nuclear SMAD2/3 signaling



    DLX1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/11 Interacting proteins for DLX1 (P561773 ENSP000003544784) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
    ALX4Q9H1613I2D: score=1 
    BARX1Q9HBU13I2D: score=1 
    CDX1P479023I2D: score=1 
    CDX4O146273I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007275multicellular organismal development NAS--
    GO:0009954proximal/distal pattern formation IEA--
    GO:0021766hippocampus development IEA--
    GO:0021879forebrain neuron differentiation ----


    DLX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DLX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLX1
    Search CenterWatch for drugs/clinical trials and news about DLX1 

    Transcripts
    for DLX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DLX1 gene (2 alternative transcripts): 
    NM_001038493.1  NM_178120.4  

    Unigene Cluster for DLX1:

    Distal-less homeobox 1
    Hs.407015  [show with all ESTs]
    Unigene Representative Sequence: NM_178120
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361609 ENST00000469444 ENST00000361725(uc002uhl.3 uc002uhm.3)
    ENST00000341900 ENST00000409492(uc010fqj.1) ENST00000475989 ENST00000550686


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLX1
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate DLX1 (see all 40):
    hsa-miR-100* hsa-let-7a-2* hsa-miR-371-5p hsa-miR-1276 hsa-miR-489 hsa-miR-23a hsa-miR-330-3p hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmid: DLX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLX1 (see all 7)
    OriGene shRNA RFP: DLX1
    OriGene siRNA: DLX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLX1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DLX1 (NM_178120)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLX1
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLX1

    Additional cDNA sequence: 

    AK290503.1 AK308842.1 AY257976.1 BC013010.2 BC036189.1 BC053351.1 

    5 DOTS entries:

    DT.97836125  DT.423086  DT.95363390  DT.91965258  DT.91968339 

    24/38 AceView cDNA sequences (see all 38):

    BC053351 BQ068101 BI914883 CR600227 CR624708 BX281379 BM016366 AY257976 
    BG491667 NM_178120 BI667479 BI755878 BI822036 AL537217 BC013010 BX441371 
    AK095266 BM561358 BE739423 BG107681 BF475569 BI913703 BI822794 BI916759 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DLX1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
    SP1:        -     -           -           -                                 
    SP2:                          -           -                                 
    SP3:                          -     -     -                                 
    SP4:                                      -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for DLX1

    Expression
    for DLX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTGTGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DLX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerImmature Ganglion CellsGanglion, Retina
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 2Cranial Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeMesencephalic Neural Crest CellsNeural Crest
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BoneMandibular ProcessBone
    BoneMaxillary ProcessBone
    BrainCerebral CortexBrain
    BrainHypothalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Ventral/hypothalamic-like neurons (Generation of midbra...)

    See DLX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLX1

    SOURCE GeneReport for Unigene cluster: Hs.407015
        SABiosciences Expression via Pathway-Focused PCR Arrays including DLX1: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX1

    Orthologs
    for DLX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DLX1 gene from 3/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DLX11 distal-less homeobox 1 85.1(n)
    89.41(a)    		   429283  NM_001045842.2  NP_001039307.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii dlx1a2 distal-less homeobox gene 1a 78.78(n)   30568  NM_131305.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dll6
    		 Distal-less
    		 24(a)
    		 possible ortholog
    		 2R(20702353-20722686)


    ENSEMBL Gene Tree for DLX1 (if available)
    TreeFam Gene Tree for DLX1 (if available) 

    Paralogs
    for DLX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLX1 gene
    DLX22  BARX12  BSX2  DLX52  DLX62  BARHL22  BARHL12  DLX42  
    BARX22  MSX22  MSX12  DLX32  
    14 SIMAP similar genes for DLX1 using alignment to 5 protein entries:     DLX1_HUMAN (see all proteins):
    MSX1    DLX6    HMX2    NKX2-5    DLX3    HLX
    NKX1-2    BARX1    DLX2    DLX5    HOXA4    HOXB1
    BARX2    DLX4

    DLX1 for paralogs           About GeneDecksing



    Genomic Variants
    for DLX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/85 NCBI SNPs in DLX1 are shown (see all 85)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1138353941,2
    		C,--164828911(+) TTGCTC/ATTAGT 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs751702941,2
    		--164828940(+) TATGCA/GTATGA 2 -- us2k10--------
    rs772236871,2
    		F,--164829292(+) GCACCC/TCAGAA 2 -- us2k12Minor allele frequency- T:0.03NA EA 240
    rs728775911,2
    		C,--164829513(+) GGAGGC/TCGGAA 2 -- us2k15Minor allele frequency- T:0.09NA WA EA 362
    rs1139196991,2
    		C,--164830306(+) GCCGGA/GAAGTG 2 -- us2k10--------
    rs168599841,2
    		C--164831827(+) CACAGA/CCTCAG 3 T P int1 mis1 ese34Minor allele frequency- C:0.01NA 136
    rs746590401,2
    		F,--164832521(+) ACTCAA/GGGGCA 2 -- int11Minor allele frequency- G:0.05NA 120
    rs1133073471,2
    		C,--164832812(+) TCTTAA/TGGGGG 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs38211861,2
    		C,--164833418(+) TCTAGC/GCTGAA 2 -- ut311Minor allele frequency- G:0.01NA 120
    rs801736871,2
    		C,F,--164833733(+) CCTGCC/TGGGCT 2 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for DLX1 (172949468 - 172954405 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DLX1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DLX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DLX1 for disorders           About GeneDecksing

    OMIM gene information: 600029    OMIM disorders: --

    6 diseases for DLX1:    About MalaCards
    autism spectrum disorder    neuronitis    syndactyly    pharyngitis
    cerebritis    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for DLX1:
    Syndactyly     Autistic disorder
    Human Genome Epidemiology (HuGE) Navigator: DLX1 (8 documents)

    Export disorders for DLX1 gene to outside databases

    Publications
    for DLX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLX1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with DLX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 3, 9 Simeone A....Boncinelli E. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. (PubMed id 14671321)1, 2 Chiba S.... Hirai H. (2003)
    4. Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling. (PubMed id 21357706)1 Starkova J....Drabkin H.A. (2011)
    5. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1 de Krom M....van Ree J.M. (2009)
    8. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PubMed id 18728693)1 Liu X....Holden J.J. (2008)
    9. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1 Kahler A.K....Andreassen O.A. (2008)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    External Searches for DLX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DLX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1745 HGNC: 2914 AceView: DLX1 Ensembl:ENSG00000144355 euGenes: HUgn1745
    ECgene: DLX1 H-InvDB: DLX1

    Other Databases showing DLX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DLX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DLX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DLX1 gene:
    Search GeneIP for patents involving DLX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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