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DLX1 Gene

protein-coding   GIFtS: 56
GCID: GC02P172949

Distal-Less Homeobox 1

(Previous name: distal-less homeo box 1)
  See DLX1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Distal-Less Homeobox 11 2
Distal-Less Homeo Box 11 2
Homeobox Protein DLX-12

External Ids:    HGNC: 29141   Entrez Gene: 17452   Ensembl: ENSG000001443557   OMIM: 6000295   UniProtKB: P561773   

Export aliases for DLX1 gene to outside databases

Previous GC identifers: GC02P171002 GC02P171610 GC02P172913 GC02P173152 GC02P172775 GC02P172657 GC02P164830


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLX1 Gene:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less
gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of
signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of
craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is
located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for DLX1 Gene:
DLX1 (distal-less homeobox 1) is a protein-coding gene. Diseases associated with DLX1 include autism spectrum disorder. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic
subdivisions (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLX1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CREB   IRF-2   E2F-1   E2F   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLX1 promoter sequence
   Search Chromatin IP Primers for DLX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

DLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLX1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172949:  view genomic region     (about GC identifiers)

Start:
172,949,468 bp from pter      End:
172,954,405 bp from pter
Size:
4,938 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177 (See protein sequence)
Recommended Name: Homeobox protein DLX-1  
Size: 255 amino acids; 27320 Da
Secondary accessions: D3DPD7 Q53ZU4 Q7Z724 Q8IYB2
Alternative splicing: 2 isoforms:  P56177-1   P56177-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLX1: NX_P56177

Explore proteomics data for DLX1 at MOPED


See DLX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001033582.1  NP_835221.2  

ENSEMBL proteins: 
 ENSP00000354865   ENSP00000448827   ENSP00000354478   ENSP00000341786  

DLX1 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for DLX1
OriGene Custom MassSpec
OriGene Custom Protein Services for DLX1
GenScript Custom Purified and Recombinant Proteins Services for DLX1
Novus Biologicals DLX1 Protein
Novus Biologicals DLX1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for DLX1

 
Search eBioscience for Proteins for DLX1 

DLX1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of DLX1
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DLX1
Novus Biologicals DLX1 Antibodies
Abcam antibodies for DLX1
Cloud-Clone Corp. Antibodies for DLX1
ThermoFisher Antibodies for DLX1
LSBio Antibodies in human, mouse, rat for DLX1

DLX1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DLX1
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GenScript Custom Assay Services for DLX1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DLX1
Cloud-Clone Corp. CLIAs for DLX1
Search eBioscience for ELISAs for DLX1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

5 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR000047 HTH_motif
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P56177

ProtoNet protein and cluster: P56177

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: DLX1_HUMAN, P56177
Similarity: Belongs to the distal-less homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with DLX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DLX1_HUMAN, P56177
Function: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in
craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic
subdivisions (By similarity)

     Genatlas biochemistry entry for DLX1:
Drosophila distal less homolog Dlx1,homeo domain encoding gene,expressed in the forebrain,facial and limb
primordia

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
GO:0003677DNA binding ----
GO:0003682chromatin binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding ----
     
Find genes that share ontologies with DLX1           About GenesLikeMe


Phenotypes:
     10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dlx1):
 cardiovascular system  cellular  craniofacial  digestive/alimentary  growth/size/body 
 hearing/vestibular/ear  mortality/aging  nervous system  no phenotypic analysis  skeleton 

Find genes that share phenotypes with DLX1           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for DLX1: Dlx1/Dlx2Dlx1/tm2Jlr Dlx1tm1Jlr

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLX1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLX1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLX1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLX1

miRNA
Products:
    
miRTarBase miRNAs that target DLX1:
hsa-mir-193b-3p (MIRT016270)

Block miRNA regulation of human, mouse, rat DLX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DLX1 (see all 40):
hsa-miR-100* hsa-let-7a-2* hsa-miR-371-5p hsa-miR-1276 hsa-miR-489 hsa-miR-23a hsa-miR-330-3p hsa-miR-376c
SwitchGear 3'UTR luciferase reporter plasmidDLX1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DLX1
Predesigned siRNA for gene silencing in human, mouse, rat DLX1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DLX1

Clone
Products:
     
OriGene clones in human, mouse for DLX1 (see all 11)
OriGene ORF clones in mouse, rat for DLX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DLX1 (NM_178120)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DLX1
Browse ESI BIO Cell Lines and PureStem Progenitors for DLX1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DLX1_HUMAN, P56177: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with DLX1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DLX1 About    
See pathways by source

SuperPathContained pathways About
1Packaging Of Telomere Ends
Signal transduction Activin A signaling regulation0.40
2Regulation of nuclear SMAD2/3 signaling
Regulation of nuclear SMAD2/3 signaling

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for DLX1
    Signal transduction Activin A signaling regulation

1 BioSystems Pathway for DLX1
    Regulation of nuclear SMAD2/3 signaling


    Pathway & Disease-focused RT2 Profiler PCR Arrays including DLX1: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for DLX1

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for DLX1 (P561773 ENSP000003544784) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
BARX1Q9HBU13, ENSP000002539684I2D: score=1 STRING: ENSP00000253968
SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
DLX2Q076873, ENSP000002341984I2D: score=1 STRING: ENSP00000234198
FOXA1P553173, ENSP000002504484I2D: score=1 STRING: ENSP00000250448
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Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007275multicellular organismal development ----
GO:0009954proximal/distal pattern formation IEA--
GO:0021544subpallium development IEA--

Find genes that share ontologies with DLX1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DLX1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DLX1 gene (2 alternative transcripts): 
NM_001038493.1  NM_178120.4  

Unigene Cluster for DLX1:

Distal-less homeobox 1
Hs.407015  [show with all ESTs]
Unigene Representative Sequence: NM_178120
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000361609 ENST00000469444 ENST00000361725(uc002uhl.3 uc002uhm.3)
ENST00000341900 ENST00000409492(uc010fqj.1) ENST00000475989 ENST00000550686

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DLX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DLX1 (see all 40):
hsa-miR-100* hsa-let-7a-2* hsa-miR-371-5p hsa-miR-1276 hsa-miR-489 hsa-miR-23a hsa-miR-330-3p hsa-miR-376c
SwitchGear 3'UTR luciferase reporter plasmidDLX1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DLX1
Predesigned siRNA for gene silencing in human, mouse, rat DLX1
Clone
Products:
     
OriGene clones in human, mouse for DLX1 (see all 11)
OriGene ORF clones in mouse, rat for DLX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): DLX1 (NM_178120)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLX1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DLX1
OriGene qSTAR qPCR primer pairs in human, mouse for DLX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLX1
  QuantiTect SYBR Green Assays in human, mouse, rat DLX1
  QuantiFast Probe-based Assays in human, mouse, rat DLX1

Additional mRNA sequence: 

AK290503.1 AK308842.1 AY257976.1 BC013010.2 BC036189.1 BC053351.1 

5 DOTS entries:

DT.97836125  DT.423086  DT.91968339  DT.95363390  DT.91965258 

Selected AceView cDNA sequences (see all 38):

BM016366 CR624708 CR600227 BX281379 BC053351 AY257976 BQ068101 BI914883 
BG491667 BE739423 BF475569 BX441371 BC036189 BI822036 BI755878 BM561358 
AK095266 CA423738 BM559101 AL537217 BI822794 NM_178120 BI667479 BC013010 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DLX1    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1:        -     -           -           -                                 
SP2:                          -           -                                 
SP3:                          -     -     -                                 
SP4:                                      -                                 
SP5:                                                                        


ECgene alternative splicing isoforms for DLX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DLX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTTGTGAAA
DLX1 Expression
About this image


DLX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 14) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
         Caudal astroglia-like cells
 
 Neural Tube (Nervous System)    fully expand to see all 6 entries
         Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
         Telencephalon
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
         Mesencephalic Neural Crest Cells Prechordal Mesenchyme
         PureStem 4D20.8, NCr-fac Progenitor
 
 Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
         Mesencephalic Neural Crest Cells Prechordal Mesenchyme
 
 Tooth
         Dental Placode Cells Dental Placode
DLX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DLX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.407015
    Pathway & Disease-focused RT2 Profiler PCR Arrays including DLX1: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for DLX1
OriGene qSTAR qPCR primer pairs in human, mouse for DLX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLX1
QuantiTect SYBR Green Assays in human, mouse, rat DLX1
QuantiFast Probe-based Assays in human, mouse, rat DLX1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DLX1 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dlx11 , 5 distal-less homeobox 11, 5 92.03(n)1
98.82(a)1
  2 (42.61 cM)5
133901  NM_010053.11  NP_034183.11 
 715281135 
chicken
(Gallus gallus)
Aves DLX11 distal-less homeobox 1 85.1(n)
89.41(a)
  429283  NM_001045842.2  NP_001039307.2 
lizard
(Anolis carolinensis)
Reptilia DLX16
distal-less homeobox 1
73(a)
1 ↔ 1
GL343353.1(411831-416517)
tropical clawed frog
(Xenopus tropicalis)
Amphibia dlx11 distal-less homeobox 1 79.42(n)
86.45(a)
  100101750  NM_001100257.1  NP_001093727.1 
zebrafish
(Danio rerio)
Actinopterygii dlx1a2 distal-less homeobox gene 1a 78.78(n)   30568  NM_131305.1 
fruit fly
(Drosophila melanogaster)
Insecta Dll6
Distal-less
27(a)
1 → many
2R(20702353-20722686)
worm
(Caenorhabditis elegans)
Secernentea ceh-436
Protein CEH-43 (ceh-43) mRNA, complete cds
27(a)
1 → many
III(4446635-4449943) WBGene00000463


ENSEMBL Gene Tree for DLX1 (if available)
TreeFam Gene Tree for DLX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DLX1 gene
DLX22  BARX12  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  
MNX12  BARX22  DLX32  LBX22  NKX1-22  BSX2  DLX52  DLX62  
DLX42  LBX12  MSX22  MSX12  
13 SIMAP similar genes for DLX1 using alignment to 4 protein entries:     DLX1_HUMAN (see all proteins):
DLX6    MSX1    HMX2    NKX2-5    DLX3    HLX
BARX1    DLX2    DLX5    HOXA4    HOXB1    BARX2
DLX4

Find genes that share paralogs with DLX1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DLX1 (see all 116)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1848559431,2
--172342718(+) CGTGTA/GGTTCG 2 -- us2k10--------
rs1433108291,2
--172342720(+) TGTGGC/TTCGGT 2 -- us2k10--------
rs1474674591,2
--172342824(+) ACCACG/TCTGCC 2 -- us2k10--------
rs1398546221,2
--172342997(+) TGTTCC/TCTCTG 2 -- us2k10--------
rs1138353941,2
C,F--172343138(+) TTGCTC/ATTAGT 2 -- us2k11Minor allele frequency- A:0.50NA 2
rs751702941,2
C--172343167(+) TATGCA/GTATGA 2 -- us2k10--------
rs1452617371,2
--172343191(+) GTGTTA/GTGCTA 2 -- us2k10--------
rs1930139041,2
C--172343201(+) AATGGC/GGCGCC 2 -- us2k10--------
rs1852026791,2
--172343203(+) TGGGGA/CGCCTT 2 -- us2k10--------
rs1152469801,2
C,F--172343385(+) TCACCG/ATGGGG 2 -- us2k12Minor allele frequency- A:0.02WA NA 238

HapMap Linkage Disequilibrium report for DLX1 (172949468 - 172954405 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DLX1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DLX1
DNA2.0 Custom Variant and Variant Library Synthesis for DLX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600029    OMIM disorders: --

1 disease for DLX1:    
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autism spectrum disorder

2 diseases from the University of Copenhagen DISEASES database for DLX1:
Syndactyly     Autistic disorder

Find genes that share disorders with DLX1           About GenesLikeMe

Genetic Association Database (GAD): DLX1
Human Genome Epidemiology (HuGE) Navigator: DLX1 (8 documents)

Export disorders for DLX1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DLX1 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with DLX1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of two members of the vertebrate Dlx gene family. (PubMed id 7907794)1, 2, 3, 9 Simeone A....Boncinelli E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  3. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PubMed id 18728693)1, 4 Liu X....Holden J.J. (Eur. J. Hum. Genet. 2009)
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
  6. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 KAohler A.K....Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. (PubMed id 14671321)1, 2 Chiba S.... Hirai H. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  9. Dlx1&amp;2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. (PubMed id 23312518)1 McKinsey G.L....Rubenstein J.L. (Neuron 2013)
  10. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1745 HGNC: 2914 AceView: DLX1 Ensembl:ENSG00000144355 euGenes: HUgn1745
ECgene: DLX1 H-InvDB: DLX1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DLX1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DLX1 gene:
Search GeneIP for patents involving DLX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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